Shampoo composition for controlling oil and dandruff and balancing and conditioning scalp and preparation method thereof

Abstract

The invention discloses a shampoo composition for controlling oil and dandruff and balancing and conditioning scalp and a preparation method of the shampoo composition, and belongs to the field of shampoo. The environment-friendly preservative is prepared from the following raw materials: 10 to 15 percent of coco-glucoside, 5 to 8 percent of sodium lauroamphoacetate, 0.6 to 1 percent of zinc pyrrolidone carboxylate, 1 to 3 percent of modified porous starch microspheres, 0.3 to 0.8 percent of piroctone olamine salt, 1 to 1.5 percent of white willow bark extract, 0.3 to 0.6 percent of alpha-glucan oligosaccharide, 2 to 4 percent of lactobacillus fermentation liquor, 0.2 to 0.4 percent of dipotassium glycyrrhizinate, 0.5 to 1.5 percent of modified barnacle glue solution and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 0.1-0.3% of ceramide NP, 1-2% of jojoba oil, 0.8-1.2% of citric acid, 2-4% of propylene glycol and the balance of deionized water. The shampoo composition has the advantages of being weak in irritation, efficient in cleaning and capable of controlling oil and dandruff, and can be used as a scalp and hair balance conditioning product for a long time.

Description

Technical Field

[0001] The present invention relates to the technical field of shampoos, and particularly relates to a shampoo composition for regulating scalp balance with oil control and dandruff control and a preparation method thereof. Background Art

[0002] The core effects of shampoos are oil control and dandruff control, which are also the most common scalp and hair problems for people. The main ingredients for oil control in the shampoo compositions on the market mainly include sulfate or amino acid surfactants, kaolin or silica adsorbents, niacinamide or PCA zinc regulators, etc., and the main ingredients for dandruff control mainly include zinc pyrithione or ketoconazole antifungal agents, salicylic acid or sulfur keratomodulators, etc.

[0003] However, the above-mentioned oil control and dandruff control ingredients in shampoos mainly have the following problems: (1) Due to the large amount of irritating ingredients, there is strong irritation, and it is easy to irritate the eyes during the shampooing and rinsing process, causing discomfort; (2) The overall oil control and dandruff control effects are average. Especially in the case of paying attention to reducing irritation, reducing the dosage or using mild ingredients will result in poor actual oil control and dandruff control effects.

[0004] Therefore, the existing oil control and dandruff control shampoos rely on chemical antibacterial and strong cleaning ingredients. Although they have quick effects, they have problems such as strong irritation and difficulty in balancing efficacy and mildness. Future research and development need to pay more attention to scalp microecological balance, ingredient safety and sustainability. Summary of the Invention

[0005] The purpose of the present invention is to provide a shampoo composition for regulating scalp balance with oil control and dandruff control and a preparation method thereof to solve the problems existing in the existing oil control and dandruff control shampoos.

[0006] The present invention realizes the above purpose through the following technical solutions:

[0007] A shampoo composition for regulating scalp balance with oil control and dandruff control, by weight percentage, its raw materials include: cocoyl glucoside 10-15%, sodium lauroamphoacetate 5-8%, zinc pyrrolidone carboxylate 0.6-1%, modified porous starch microspheres 1-3%, piroctone olamine 0.3-0.8%, white willow bark extract 1-1.5%, α-glucan oligosaccharide 0.3-0.6%, lactic acid bacteria fermentation broth 2-4%, dipotassium glycyrrhizinate 0.2-0.4%, modified barnacle glue solution 0.5-1.5%, ceramide NP 0.1-0.3%, jojoba oil 1-2%, citric acid 0.8-1.2%, propylene glycol 2-4%, and the balance is deionized water.

[0008] The present invention also provides a preparation method of the shampoo composition for regulating scalp balance with oil control and dandruff control, and the steps are as follows:

[0009] S1, Preparation of the aqueous phase

[0010] In a constant temperature water bath at 65 - 75°C, mix deionized water with α-glucan oligosaccharide, lactic acid bacteria fermentation broth, and dipotassium glycyrrhizinate, stir to dissolve. Then, after reducing the water bath temperature to 40 - 50°C, add coconut glucoside and sodium lauroamphoacetate in sequence, and homogenize to obtain an aqueous phase system;

[0011] S2, Addition of the functional phase

[0012] First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract, and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment. After the system cools down to 32 - 36°C, add ceramide NP dissolved in jojoba oil, and stir to disperse;

[0013] S3, Adjustment

[0014] Add modified barnacle glue solution to the system, homogenize, and then adjust the pH of the system to 5.7 - 5.9 with citric acid;

[0015] S4, Final product treatment:

[0016] Vacuum degas the system, fill it, and obtain the shampoo composition.

[0017] Further improvement lies in that in step S1, the conditions for stirring and dissolving are stirring at a speed of 200 - 400 rpm for 15 - 18 min, and the conditions for homogenizing are homogenizing at a speed of 800 - 1000 rpm for 8 - 10 min.

[0018] Further improvement lies in that in step S2, the conditions for ultrasonic treatment are a power of 40 - 50 kHz and a time of 8 - 12 min.

[0019] Further improvement lies in that in step S2, the preparation steps of the modified porous starch microspheres are as follows: Take corn porous starch and uniformly disperse it in 2 - 4 times the mass of pure water to obtain a starch emulsion. Add a 1 mol / L potassium chloride solution accounting for 0.1 - 0.3% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and pulverize to obtain the modified porous starch microspheres; wherein, the electric field strength of the pulsed electric field treatment is 10 - 20 kV / cm, the pulse frequency is 400 - 600 Hz, and the treatment time is 40 - 80 min.

[0020] Further improvement lies in that in step S2, the conditions for stirring and dispersing are stirring at a speed of 180 - 220 rpm for 8 - 10 min.

[0021] A further improvement is that in step S3, the preparation steps of the modified barnacle glue are: take dry barnacle glue, ball mill and sieve to obtain glue powder with a particle size of 20-100nm, then add the glue powder to the sodium dodecyl sulfate aqueous solution at a ratio of 1mg glue powder: 0.8-1.2mL sodium dodecyl sulfate aqueous solution, let it stand for 10-15d and shake it every 12-24h during the standing period, and the modified barnacle glue is obtained after the standing is completed.

[0022] A further improvement is that the mass concentration of the sodium dodecyl sulfate aqueous solution is 1-1.5%.

[0023] A further improvement is that in step S3, the homogenization condition is stirring at a speed of 220-260 rpm for 8-10 min.

[0024] A further improvement is that in step S4, the vacuum degassing conditions are pressure -0.08MPa and time 8-10min.

[0025] The beneficial effects of the present invention are as follows: the shampoo composition of the present invention uses coconut glucoside and sodium lauroamphoacetate as main cleaning components, uses zinc pyrrolidone carboxylate and modified porous starch microspheres as main oil-controlling components, uses piroctone olamine salt and white willow bark extract as main dandruff-controlling components, uses α-glucan oligosaccharide and lactobacillus fermentation broth microecological regulating components, uses dipotassium glycyrrhizinate and ceramide NP as main soothing and repairing components, uses modified barnacle glue as a comprehensive conditioning component, and is combined with some auxiliary agents, so that the shampoo can have the advantages of weak irritation, high-efficiency cleaning, oil control and dandruff control, and can be used as a scalp and hair balancing conditioning product for a long time.

[0026] In addition, the modified barnacle glue liquid is treated with an aqueous solution of sodium dodecyl sulfate, which can partially open the protein structure of the barnacle glue and expose its adhesion active sites, thereby solving the problem of excessive adhesion of the barnacle glue, improving its dispersibility, and making it easy to clean. At the same time, its barrier effect can be used to reduce sebaceous gland secretion, reduce stratum corneum exfoliation, and further enhance the oil and dandruff control effects, thereby reducing the use of other irritating ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a diagram showing the damaged state of the blood vessels and vascular network of the chorioallantoic membrane of a chicken embryo after being treated with the shampoo composition of the present invention;

[0028] Figure 2 The figure shows the anti-dandruff effect of the shampoo composition of the present invention. DETAILED DESCRIPTION

[0029] The present application will be further described in detail below with reference to the accompanying drawings. It is necessary to point out here that the following specific embodiments are only used to further illustrate the present application and should not be construed as limiting the protection scope of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.

[0030] I. Main raw materials:

[0031] Coconut oil-based glucoside: Purchased from Shandong Yousuo Chemical Technology Co., Ltd.;

[0032] Sodium lauroamphoacetate: Purchased from Shandong Yousuo Chemical Technology Co., Ltd.;

[0033] Zinc pyrrolidone carboxylate: Purchased from Xi'an Rongzhen Biotechnology Co., Ltd.;

[0034] Corn porous starch: Purchased from Shaanxi Zeland Biotechnology Co., Ltd.;

[0035] Piroctone olamine: CAS No. 68890-66-4, purchased from Xi'an Xihai Biotechnology Co., Ltd.;

[0036] White willow bark extract: Model TG-519A, purchased from Sanyou Biology;

[0037] α-Glucan oligosaccharide: Purchased from Xi'an Zhengte Biopharmaceutical Technology Co., Ltd.;

[0038] Lactobacillus fermentation broth: Prepared by oneself. The fermentation process is as follows: Select MRS liquid medium, inoculate Lactobacillus ATCC393, and perform anaerobic fermentation for 5 days at room temperature.

[0039] Dipotassium glycyrrhizinate: Purchased from Shaanxi Saien Biotechnology Co., Ltd.;

[0040] Barnacle glue: Select the primary glue of Balanus amphitrite, dry the light yellow glue film, and keep it for self-use;

[0041] Ceramide NP: Purchased from Huzhou Pure Biotechnology Co., Ltd.;

[0042] Jojoba oil: Purchased from Lvyuan Natural Spice Oil Refinery in Qingyuan District, Ji'an City;

[0043] Citric acid: Purchased from Wuhan Dexinjin Biotechnology Co., Ltd.;

[0044] Propylene glycol: Purchased from Hongfa Chemical Business Department in Jiyang, Jinan.

[0045] II. Specific implementation experiments

[0046] Example 1

[0047] An oil-control and anti-dandruff scalp balance conditioning shampoo composition, by weight percentage, its raw materials include: cocoyl glucoside 10%, sodium lauroamphoacetate 8%, zinc pyrrolidone carboxylate 0.6%, modified porous starch microspheres 3%, piroctone olamine 0.3%, white willow bark extract 1.5%, α-glucan oligosaccharide 0.3%, lactobacillus ferment 4%, dipotassium glycyrrhizinate 0.2%, modified barnacle glue solution 0.5%, ceramide NP 0.3%, jojoba oil 1%, citric acid 0.8%, propylene glycol 2%, deionized water 67.5%.

[0048] The preparation method of the oil-control and anti-dandruff scalp balance conditioning shampoo composition is as follows:

[0049] S1. Preparation of aqueous phase

[0050] In a 65°C constant temperature water bath, mix deionized water with α-glucan oligosaccharide, lactobacillus ferment, and dipotassium glycyrrhizinate, stir at a speed of 200 rpm for 18 min, then lower the water bath temperature to 40°C, and successively add cocoyl glucoside and sodium lauroamphoacetate, and homogenize at a speed of 800 rpm for 10 min to obtain an aqueous phase system;

[0051] S2. Addition of functional phase

[0052] First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract, and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment (power 40 kHz, time 12 min), and after the system cools down to 32°C, add ceramide NP dissolved in jojoba oil, and stir at a speed of 180 rpm for 10 min; among them, the preparation steps of the modified porous starch microspheres are: take corn porous starch and disperse it evenly in 2 times the mass of pure water to obtain a starch emulsion, add 1 mol / L potassium chloride solution accounting for 0.1% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and crush to obtain modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 10 kV / cm, the pulse frequency is 400 Hz, and the treatment time is 80 min;

[0053] S3. Adjustment

[0054] Add the modified barnacle glue solution to the system, stir at a speed of 220 rpm for 10 min, and then adjust the pH of the system to 5.7 with citric acid; among them, the preparation steps of the modified barnacle glue solution are: take dry barnacle glue, grind it through a sieve to obtain a glue powder with a particle size of 20 - 30 nm, and then add the glue powder to a 1.5% sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder: 0.8 mL of sodium dodecyl sulfate aqueous solution, let it stand for 10 d and shake it once every 12 h during the standing period, and the modified barnacle glue solution is obtained after standing.

[0055] S4. Final product treatment:

[0056] Vacuum degas the system (pressure -0.08 MPa, time 8 min), and then fill it to obtain the shampoo composition.

[0057] Example 2

[0058] A shampoo composition for controlling oil and dandruff and balancing scalp conditioning, by weight percentage, its raw materials include: cocoyl glucoside 12%, sodium lauroamphoacetate 6%, zinc pyrrolidone carboxylate 0.8%, modified porous starch microspheres 2%, piroctone olamine 0.5%, white willow bark extract 1.2%, α-glucan oligosaccharide 0.5%, lactobacillus ferment 3%, dipotassium glycyrrhizinate 0.3%, modified barnacle glue solution 1%, ceramide NP 0.2%, jojoba oil 1.5%, citric acid 1%, propylene glycol 3%, deionized water 67%.

[0059] The preparation method of the shampoo composition for controlling oil and dandruff and balancing scalp conditioning is as follows:

[0060] S1. Aqueous phase preparation

[0061] In a 70°C constant temperature water bath, mix deionized water with α-glucan oligosaccharide, lactobacillus ferment, and dipotassium glycyrrhizinate, stir at a speed of 300 rpm for 16 min, then lower the water bath temperature to 45°C, and successively add cocoyl glucoside and sodium lauroamphoacetate, and homogenize at a speed of 900 rpm for 9 min to obtain an aqueous phase system;

[0062] S2. Functional phase addition

[0063] First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment (power 45 kHz, time 10 min), and after the system cools down to 34°C, add ceramide NP dissolved in jojoba oil, and stir at a speed of 200 rpm for 9 min; among them, the preparation steps of the modified porous starch microspheres are: take corn porous starch and disperse it evenly in 3 times the mass of pure water to obtain a starch emulsion, add 1 mol / L potassium chloride solution accounting for 0.2% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and crush to obtain modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 15 kV / cm, the pulse frequency is 500 Hz, and the treatment time is 60 min;

[0064] S3. Adjustment

[0065] Add the modified barnacle glue solution to the system, stir at a speed of 240 rpm for 9 min, and then adjust the pH of the system to 5.8 with citric acid. The preparation steps of the modified barnacle glue solution are as follows: Take the dried barnacle glue, grind it through a sieve to obtain glue powder with a particle size of 50-60 nm, and then add the glue powder to a 1.2% sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder: 1 mL of sodium dodecyl sulfate aqueous solution, let it stand for 12 d, and shake it once every 12 h during the standing period. After the standing is completed, the modified barnacle glue solution is obtained.

[0066] S4. Final product treatment:

[0067] Vacuum degas the system (pressure -0.08 MPa, time 9 min), and then fill it to obtain the shampoo composition.

[0068] Example 3

[0069] A shampoo composition for controlling oil and dandruff and balancing the scalp, by weight percentage, its raw materials include: cocoyl glucoside 15%, sodium lauroamphoacetate 5%, zinc pyrrolidone carboxylate 1%, modified porous starch microspheres 1%, piroctone olamine 0.8%, white willow bark extract 1%, α-glucan oligosaccharide 0.6%, lactobacillus ferment 2%, dipotassium glycyrrhizinate 0.4%, modified barnacle glue solution 1.5%, ceramide NP 0.1%, jojoba oil 2%, citric acid 1.2%, propylene glycol 4%, deionized water 64.4%.

[0070] The preparation method of the shampoo composition for controlling oil and dandruff and balancing the scalp is as follows:

[0071] S1. Aqueous phase preparation

[0072] In a 75°C constant temperature water bath, mix deionized water with α-glucan oligosaccharide, lactobacillus ferment, and dipotassium glycyrrhizinate, stir at a speed of 400 rpm for 15 min, then lower the water bath temperature to 50°C, and then sequentially add cocoyl glucoside and sodium lauroamphoacetate, and homogenize at a speed of 1000 rpm for 8 min to obtain an aqueous phase system.

[0073] S2. Functional phase addition

[0074] First, zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract and modified porous starch microspheres are pre-dispersed in propylene glycol. After ultrasonic treatment (power 50 kHz, time 8 min), they are added to the system. After the system cools down to 36 °C, ceramide NP dissolved in jojoba oil is added, and the mixture is stirred at a speed of 220 rpm for 8 min. Among them, the preparation steps of the modified porous starch microspheres are as follows: Take corn porous starch and uniformly disperse it in 4 times the mass of pure water to obtain a starch emulsion. Add 1 mol / L potassium chloride solution accounting for 0.3% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, it is filtered, dried, and pulverized to obtain the modified porous starch microspheres. Among them, the electric field strength of the pulsed electric field treatment is 20 kV / cm, the pulse frequency is 600 Hz, and the treatment time is 40 min.

[0075] S3. Adjust

[0076] Add the modified barnacle glue solution to the system, stir at a speed of 260 rpm for 8 min, and then adjust the pH of the system to 5.9 with citric acid. Among them, the preparation steps of the modified barnacle glue solution are as follows: Take dry barnacle glue, grind it through a sieve to obtain glue powder with a particle size of 90 - 100 nm, and then add the glue powder to a 1% sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder : 1.2 mL of sodium dodecyl sulfate aqueous solution. Let it stand for 15 d and shake it once every 24 h during the standing period. After standing, the modified barnacle glue solution is obtained.

[0077] S4. Final product treatment:

[0078] Vacuum degas the system (pressure -0.08 MPa, time 10 min), and then fill it to obtain the shampoo composition.

[0079] Comparative Example 1

[0080] A shampoo composition for controlling oil and dandruff and balancing scalp conditioning, by weight percentage, its raw materials include: 12% cocoyl glucoside, 6% sodium lauroamphoacetate, 0.8% zinc pyrrolidone carboxylate, 2% modified porous starch microspheres, 0.5% piroctone olamine, 1.2% white willow bark extract, 0.5% α-glucooligosaccharide, 3% lactobacillus ferment, 0.3% dipotassium glycyrrhizinate, 0.2% ceramide NP, 1.5% jojoba oil, 1% citric acid, 3% propylene glycol, 68% deionized water.

[0081] The preparation method of the shampoo composition for controlling oil and dandruff and balancing scalp conditioning is as follows:

[0082] S1. Aqueous phase preparation

[0083] In a constant temperature water bath at 70°C, deionized water, α-glucan oligosaccharide, lactobacillus fermentation broth and dipotassium glycyrrhizinate were mixed and stirred at 300 rpm for 16 min. After the water bath temperature was lowered to 45°C, cocoyl glucoside and sodium lauroamphoacetate were added in sequence and homogenized at 900 rpm for 9 min to obtain an aqueous phase system.

[0084] S2, Functional addition

[0085] First, zinc pyrrolidone carboxylate, piroctone olamine salt, white willow bark extract and modified porous starch microspheres are pre-dispersed in propylene glycol, and then added to the system after ultrasonic treatment (power 45kHz, time 10min), and after the system is cooled to 34°C, ceramide NP dissolved in jojoba oil is added, and stirred at a speed of 200rpm for 9min; wherein, the preparation steps of the modified porous starch microspheres are: taking corn porous starch and uniformly dispersing it in 3 times the mass of pure water to obtain starch emulsion, adding 1mol / L potassium chloride solution accounting for 0.2% of the mass of the starch emulsion to the starch emulsion, and then applying a pulse electric field treatment to the starch emulsion, filtering, drying, and crushing after treatment to obtain the modified porous starch microspheres; wherein, the electric field strength of the pulse electric field treatment is 15kV / cm, the pulse frequency is 500Hz, and the treatment time is 60min;

[0086] S3. Adjustment

[0087] The pH of the system was adjusted to 5.8 with citric acid;

[0088] S4. Final product processing:

[0089] The system was vacuum degassed (pressure -0.08 MPa, time 9 min), and then filled to obtain the shampoo composition.

[0090] Comparative Example 2

[0091] The invention discloses an oil-controlling, dandruff-controlling, scalp-balancing and conditioning shampoo composition. The raw materials thereof include, by weight percentage, 12% of cocoyl glucoside, 6% of sodium lauroamphoacetate, 0.8% of zinc pyrrolidone carboxylate, 2% of modified porous starch microspheres, 0.5% of piroctone olamine salt, 1.2% of white willow bark extract, 0.5% of α-glucan oligosaccharide, 3% of lactobacillus fermentation broth, 0.3% of dipotassium glycyrrhizate, 1% of barnacle glue, 0.2% of ceramide NP, 1.5% of jojoba oil, 1% of citric acid, 3% of propylene glycol and 67% of deionized water.

[0092] The preparation method of the shampoo composition for oil-controlling, dandruff-controlling, scalp-balancing and conditioning comprises the following steps:

[0093] S1. Preparation of aqueous phase

[0094] In a 70 °C constant temperature water bath, deionized water is mixed with α-glucooligosaccharide, Lactobacillus fermentation broth, and dipotassium glycyrrhizinate, and stirred at a speed of 300 rpm for 16 min. Then, after the water bath temperature is lowered to 45 °C, cocoyl glucoside and sodium lauroamphoacetate are added in sequence, and homogenized at a speed of 900 rpm for 9 min to obtain an aqueous phase system;

[0095] S2. Addition of functional phase

[0096] First, zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract and modified porous starch microspheres are pre-dispersed in propylene glycol, and after ultrasonic treatment (power 45 kHz, time 10 min), they are added to the system. After the system cools down to 34 °C, ceramide NP dissolved in jojoba oil is added, and stirred at a speed of 200 rpm for 9 min; among them, the preparation steps of the modified porous starch microspheres are as follows: Take corn porous starch and disperse it evenly in 3 times the mass of pure water to obtain a starch emulsion. Add 1 mol / L potassium chloride solution accounting for 0.2% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, it is filtered, dried, and pulverized to obtain modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 15 kV / cm, the pulse frequency is 500 Hz, and the treatment time is 60 min;

[0097] S3. Adjustment

[0098] Add barnacle glue solution to the system, stir at a speed of 240 rpm for 9 min, and then adjust the pH of the system to 5.8 with citric acid; among them, the preparation steps of the barnacle glue solution are as follows: Take dry barnacle glue, grind it through a sieve to obtain a glue powder with a particle size of 50 - 60 nm, and then add the glue powder to pure water according to the ratio of 1 mg of glue powder: 1 mL of pure water, let it stand for 12 d, and shake it once every 12 h during the standing period. After standing, the barnacle glue solution is obtained;

[0099] S4. Final product treatment:

[0100] The system is vacuum degassed (pressure -0.08 MPa, time 9 min), and then filled to obtain the shampoo composition.

[0101] Comparative Example 3

[0102] An oil-control and anti-dandruff scalp balance conditioning shampoo composition, by weight percentage, its raw materials include: 12% of cocoyl glucoside, 6% of sodium lauroamphoacetate, 0.8% of zinc pyrrolidone carboxylate, 2% of modified porous starch microspheres, 0.5% of piroctone olamine, 1.2% of white willow bark extract, 0.5% of α-glucooligosaccharide, 3% of Lactobacillus fermentation broth, 0.3% of dipotassium glycyrrhizinate, 2% of modified barnacle glue solution, 0.2% of ceramide NP, 1.5% of jojoba oil, 1% of citric acid, 3% of propylene glycol, and 66% of deionized water.

[0103] The preparation method of the oil-control and dandruff-control scalp balance conditioning shampoo composition is as follows:

[0104] S1. Preparation of aqueous phase

[0105] In a 70°C constant temperature water bath, mix deionized water with α-glucan oligosaccharide, Lactobacillus fermentation broth, and dipotassium glycyrrhizinate, stir at a speed of 300 rpm for 16 min, then lower the water bath temperature to 45°C, and successively add coconut glucoside and sodium lauroamphoacetate, and homogenize at a speed of 900 rpm for 9 min to obtain an aqueous phase system;

[0106] S2. Addition of functional phase

[0107] First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract, and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment (power 45 kHz, time 10 min), and after the system cools down to 34°C, add ceramide NP dissolved in jojoba oil, and stir at a speed of 200 rpm for 9 min; among them, the preparation steps of the modified porous starch microspheres are as follows: take corn porous starch and uniformly disperse it in 3 times the mass of pure water to obtain a starch emulsion, add 1 mol / L potassium chloride solution accounting for 0.2% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and pulverize to obtain the modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 15 kV / cm, the pulse frequency is 500 Hz, and the treatment time is 60 min;

[0108] S3. Adjustment

[0109] Add modified barnacle glue solution to the system, stir at a speed of 240 rpm for 9 min, and then adjust the pH of the system to 5.8 with citric acid; among them, the preparation steps of the modified barnacle glue solution are as follows: take dry barnacle glue, grind and sieve it to obtain glue powder with a particle size of 50 - 60 nm, and then add the glue powder to a 1.2% sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder: 1 mL of sodium dodecyl sulfate aqueous solution, let it stand for 12 d, and shake it once every 12 h during the standing period. After standing, the modified barnacle glue solution is obtained;

[0110] S4. Final product treatment:

[0111] Vacuum degas the system (pressure -0.08 MPa, time 9 min), and fill it to obtain the shampoo composition.

[0112] Comparative Example 4

[0113] An oil-control and dandruff-control scalp balance conditioning shampoo composition, by weight percentage, its raw materials include: cocoyl glucoside 12%, sodium lauroamphoacetate 6%, zinc pyrrolidone carboxylate 0.8%, modified porous starch microspheres 2%, piroctone olamine 0.5%, white willow bark extract 1.2%, α-glucan oligosaccharide 0.5%, lactobacillus ferment 3%, dipotassium glycyrrhizinate 0.3%, modified barnacle glue solution 2.5%, ceramide NP 0.2%, jojoba oil 1.5%, citric acid 1%, propylene glycol 3%, deionized water 65.5%.

[0114] The preparation method of the oil-control and dandruff-control scalp balance conditioning shampoo composition is as follows:

[0115] S1. Aqueous phase preparation

[0116] In a 70°C constant temperature water bath, mix deionized water with α-glucan oligosaccharide, lactobacillus ferment, and dipotassium glycyrrhizinate, stir at a speed of 300 rpm for 16 min, then after reducing the water bath temperature to 45°C, successively add cocoyl glucoside and sodium lauroamphoacetate, and homogenize at a speed of 900 rpm for 9 min to obtain an aqueous phase system;

[0117] S2. Functional phase addition

[0118] First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract, and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment (power 45 kHz, time 10 min), and after the system cools down to 34°C, add ceramide NP dissolved in jojoba oil, and stir at a speed of 200 rpm for 9 min; among them, the preparation steps of the modified porous starch microspheres are: take corn porous starch and uniformly disperse it in 3 times the mass of pure water to obtain a starch emulsion, add 1 mol / L potassium chloride solution accounting for 0.2% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and crush to obtain modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 15 kV / cm, the pulse frequency is 500 Hz, and the treatment time is 60 min;

[0119] S3. Adjustment

[0120] Add the modified barnacle glue solution to the system, stir at a speed of 240 rpm for 9 min, and then adjust the pH of the system to 5.8 with citric acid; among them, the preparation steps of the modified barnacle glue solution are: take dry barnacle glue, grind and sieve it to obtain a glue powder with a particle size of 50 - 60 nm, and then add the glue powder to a 1.2% sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder: 1 mL of sodium dodecyl sulfate aqueous solution, let it stand for 12 d and shake it once every 12 h during the standing period, and the modified barnacle glue solution is obtained after standing;

[0121] S4. Final product treatment:

[0122] Vacuum degas the system (pressure -0.08 MPa, time 9 min), then fill it to obtain the shampoo composition.

[0123] III. Performance testing

[0124] (1) Safety testing:

[0125] The safety testing is carried out with reference to the test methods in Chapter 7 of the "Technical Specifications for Cosmetics Safety (2015 Edition)". The human skin patch test is adopted. Select 100 volunteers (actual ages ranging from 20 to 55 years old) as the test subjects (excluding insulin-dependent diabetes patients, patients with asthma or other chronic respiratory diseases under treatment, highly sensitive individuals, lactating or pregnant women, etc. The selected qualified volunteers sign the informed consent form). Select a suitable patch tester with an area not exceeding 50 mm 2 , and a depth of 1 mm to detect the potential possibility of the shampoo compositions prepared in Examples 1-3 causing adverse reactions on human skin.

[0126] The specific detection process is as follows: Put the shampoo composition sample into the small chamber of the patch tester, with a dosage of 0.02 ml. The control hole uses distilled water as a blank control. Apply the patch tester with the sample on the flexor side of the forearm of the subject, and gently press it with the palm to make it evenly adhere to the skin for 24 h. Observe the skin reaction according to the grading standard in Table 1 below at 30 min, 24 h, and 48 h after removing the patch tester with the test substance, and record the results.

[0127] Table 1: Grading standard for skin reactions in the closed patch test

[0128]

[0129]

[0130] (2) Eye irritation test:

[0131] Refer to the "Allantoic Membrane Test of Chicken Embryos for Eye Irritation and Corrosion of Cosmetics (SN / T 2329-2009)" to conduct the allantoic membrane test of chicken embryos to evaluate the eye irritation of the shampoo composition prepared in Example 2. Observe the damage status diagram of blood vessels and blood vessel networks on the allantoic membrane of chicken embryos at 5 min, calculate the irritation score IS value, and then evaluate the irritation according to the calculated IS value according to Table 2 below:

[0132] Table 2: Result evaluation standard for the irritation scoring method

[0133]

[0134] (3) Oil and dandruff control, cleaning effect test:

[0135] Subjects: There were 30 subjects in total, including 5 males and 25 females; aged 19 - 48 years old.

[0136] Inclusion criteria: ① Scalp-sensitive individuals aged 18 - 60 years old with long-term problems of oily scalp and dandruff; ② Without allergic diseases, no history of allergies to cosmetics and other topical preparations; ③ Able to understand the test process, voluntarily participate in the test and sign a written informed consent form.

[0137] Exclusion criteria: ① Those with scalp skin diseases such as eczema, psoriasis, tinea capitis, pityriasis steatoides or obvious seborrheic dermatitis on the head; ② Those who participated in drug clinical trials or other tests within 30 days; ③ Those who had used topical or oral antifungal drugs or glucocorticoids within 1 month.

[0138] Test process: The subjects were randomly divided into 5 groups, with 6 people in each group. First, they were washed and cared for once with the same ordinary shampoo (a certain brand of cleansing shampoo purchased on the market). After a 48-hour interval between washing and caring, the SebumScale skin sebum tester was used to measure the scalp oil content data (average value) on the top of the head of each group of subjects, and the VisioScan VC20 skin test instrument was used to observe the dandruff situation of each group of subjects, and the dandruff was evaluated with reference to Table 3 below. The test area was 5 cm backward from the midpoint of the forehead hairline; then, in the same washing and caring method (washing and caring once every 48 hours, each time the shampoo was evenly applied to the hair and the scalp was massaged for 5 minutes, then rinsed with clean water and immediately dried with a hair dryer), each group of subjects continuously used the shampoo composition samples of Example 2 and Comparative Examples 1 - 4 above. After the 15th use of the sample, after another 48-hour interval, the scalp oil content data on the top of the head of each group of subjects was measured again, and the dandruff situation of the subjects was observed and evaluated. In addition, each group of subjects gave a sensory score to the overall cleaning and softness of the shampoo composition sample after each use, with a full score of 100 points, and the average score of each group was statistically calculated.

[0139] Table 3: Dandruff grade evaluation criteria

[0140]

[0141] IV. Result analysis

[0142] (1) Safety test:

[0143] Finally, all 100 volunteers completed the 24-hour skin closed patch test of Examples 1 - 3. After removing the patch tester for 30 minutes, 24 hours, and 48 hours, the shampoo compositions of Examples 1 - 3 did not cause adverse reactions to the skin, that is, all were grade 0 negative reactions. It shows that under normal circumstances, skin contact with the specified dose will not cause scalp reactions, and all components can be used safely.

[0144] (2) Eye irritation test:

[0145] The damaged state of blood vessels and vascular networks in the chorioallantoic membrane of chicken embryos of the shampoo composition sample in Example 2 at 5 minutes is as Figure 1 shown. It can be seen that there are no obvious changes in the blood vessels after treatment with the sample of Example 2, and there are no obvious bleeding, coagulation, and vascular lysis phenomena. In addition, after calculation, the irritation score IS value is 4.12, which is a mild irritation. Considering that the shampoo will be diluted during the flushing process, it is considered that at normal use concentrations, the shampoo composition of the present invention will not pose a risk of eye irritation.

[0146] (3) Oil control, dandruff control, and cleaning effect test:

[0147] The data of the oil content of the scalp on the top of the heads of the subjects in each group, the evaluation of dandruff, and the overall cleaning and softness score are shown in Table 4 below. In addition, as Figure 2 shown, it is a diagram showing the dandruff condition of a randomly selected subject in Example 2 before and after use. From the above comprehensive results, it can be seen that the shampoo composition prepared in Example 2 of the present invention has outstanding oil control and dandruff control effects. The scalp oil has decreased by 52.9%, the dandruff symptoms have changed from severe to no dandruff, and the cleaning effect is outstanding, with a score as high as 92.8. Figure 2 Among them, A shows the dandruff condition of the subject in Example 2 before use, and B shows the dandruff condition after use, which is consistent with the above overall dandruff evaluation.

[0148] Comparative Examples 1-4 are adjustments made on the basis of Example 2. Among them: In Comparative Example 1, due to the removal of the modified barnacle glue solution component, the oil control and dandruff control effects are significantly deteriorated, but the cleaning effect is still relatively good, which is basically equivalent to that of Example 2, indicating that the addition of the modified barnacle glue solution component has an obvious promoting effect on the oil control and dandruff control effects, and has basically no influence on the cleaning effect; in Comparative Example 2, since the barnacle glue was not modified and the barnacle glue solution was directly added, the oil control and dandruff control effects are significantly worse than those in Example 2, and the oil control effect is even inferior to that in Comparative Example 1. This shows that ordinary barnacle glue cannot play a promoting role in oil control and dandruff control, and has a greater impact on the cleaning effect, so it cannot be directly applied; in Comparative Examples 3 and 4, the dosage of the modified barnacle glue solution was increased to 2% and 2.5% respectively. It can be seen that after the dosage is increased, it does not play a further promoting role in oil control and dandruff control, but instead makes the effect decline, and the cleaning effect also significantly decreases, indicating that the dosage of the modified barnacle glue solution should not be too large, otherwise negative effects will occur. Analyzing the reason may be that too much modified barnacle glue solution hinders the metabolism of the stratum corneum and reduces the cleaning efficiency, ultimately resulting in worse oil control and dandruff control effects.

[0149] Table 4: Test results of oil control, dandruff control, and cleaning effect

[0150]

[0151] The above-described embodiments merely represent several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several variations and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A shampoo composition for controlling oil and dandruff and balancing scalp conditioning, characterized in that, By weight percentage, its raw materials include: cocoyl glucoside 10 - 15%, sodium lauroamphoacetate 5 - 8%, zinc pyrrolidone carboxylate 0.6 - 1%, modified porous starch microspheres 1 - 3%, piroctone olamine 0.3 - 0.8%, white willow bark extract 1 - 1.5%, α-glucan oligosaccharide 0.3 - 0.6%, lactobacillus ferment 2 - 4%, dipotassium glycyrrhizinate 0.2 - 0.4%, modified barnacle glue solution 0.5 - 1.5%, ceramide NP 0.1 - 0.3%, jojoba oil 1 - 2%, citric acid 0.8 - 1.2%, propylene glycol 2 - 4%, and the balance is deionized water.

2. A method for preparing a shampoo composition for controlling oil and dandruff and balancing scalp conditioning as described in claim 1, characterized in that, The steps are as follows: S1. Preparation of aqueous phase In a constant temperature water bath at 65 - 75°C, mix deionized water with α-glucan oligosaccharide, lactobacillus ferment, and dipotassium glycyrrhizinate, stir to dissolve, then after lowering the water bath temperature to 40 - 50°C, successively add cocoyl glucoside and sodium lauroamphoacetate, and homogenize to obtain an aqueous phase system; S2. Addition of functional phase First, pre-disperse zinc pyrrolidone carboxylate, piroctone olamine, white willow bark extract, and modified porous starch microspheres in propylene glycol, add them to the system after ultrasonic treatment, and after the system cools down to 32 - 36°C, add ceramide NP dissolved in jojoba oil, and stir to disperse; S3. Adjustment Add the modified barnacle glue solution to the system, homogenize, and then adjust the pH of the system to 5.7 - 5.9 with citric acid; S4. Final product treatment: Vacuum degas the system, fill it, and obtain the shampoo composition.

3. The preparation method of the shampoo composition for controlling oil and dandruff and balancing scalp conditioning according to claim 2, wherein, In step S1, the conditions for stirring and dissolving are stirring at a speed of 200 - 400 rpm for 15 - 18 min, and the conditions for homogenizing are homogenizing at a speed of 800 - 1000 rpm for 8 - 10 min.

4. The preparation method of the shampoo composition for controlling oil and dandruff and conditioning the scalp balance according to claim 2, characterized in that, In step S2, the conditions for ultrasonic treatment are a power of 40 - 50 kHz and a time of 8 - 12 min.

5. The preparation method of the shampoo composition for controlling oil and dandruff and conditioning the scalp balance according to claim 2, wherein, In step S2, the preparation steps of the modified porous starch microspheres are as follows: Take corn porous starch and uniformly disperse it in 2 - 4 times the mass of pure water to obtain a starch emulsion. Add a 1 mol / L potassium chloride solution accounting for 0.1 - 0.3% of the mass of the starch emulsion to the starch emulsion, and then apply pulsed electric field treatment to the starch emulsion. After treatment, filter, dry, and pulverize to obtain the modified porous starch microspheres; among them, the electric field strength of the pulsed electric field treatment is 10 - 20 kV / cm, the pulse frequency is 400 - 600 Hz, and the treatment time is 40 - 80 min.

6. The preparation method of the oil-control and dandruff-control scalp balance conditioning shampoo composition according to claim 2, wherein, In step S2, the conditions for stirring and dispersing are stirring at a speed of 180 - 220 rpm for 8 - 10 min.

7. The preparation method of the oil-control and dandruff-control scalp balancing conditioning shampoo composition according to claim 2, characterized in that, In step S3, the preparation steps of the modified barnacle glue solution are as follows: Take dry barnacle glue, grind it through a sieve to obtain a glue powder with a particle size of 20 - 100 nm, and then add the glue powder to a sodium dodecyl sulfate aqueous solution according to the ratio of 1 mg of glue powder: 0.8 - 1.2 mL of sodium dodecyl sulfate aqueous solution, let it stand for 10 - 15 d, and shake it once every 12 - 24 h during the standing period. After standing, the modified barnacle glue solution is obtained.

8. The preparation method of the shampoo composition for controlling oil and dandruff and conditioning the scalp balance according to claim 7, characterized in that, The mass concentration of the sodium dodecyl sulfate aqueous solution is 1 - 1.5%.

9. The preparation method of the oil-control and dandruff-control scalp balancing conditioning shampoo composition according to claim 2, characterized in that, In step S3, the conditions for homogenization are stirring at a speed of 220 - 260 rpm for 8 - 10 min.

10. The preparation method of the shampoo composition for controlling oil and dandruff and scalp balance conditioning according to claim 2, characterized in that, In step S4, the conditions for vacuum degassing are a pressure of -0.08 MPa and a time of 8 - 10 min.

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