Traditional Chinese medicine composition for treating norovirus infection and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating norovirus infection and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6g to 12g of poria cocos, 6g to 12g of rhizoma alismatis, 8g to 15g of herba eupatorii, 10g to 18g of talc, 8g to 12g of agastache rugosus, 5g to 10g of massa medicata fermentata fujianensis, 8g to 12g of radix aucklandiae, 15g to 25g of radix puerariae and 4g to 8g of rhizoma coptidis. The preparation method of the traditional Chinese medicine composition comprises the following steps: taking the raw materials in parts by weight, adding the traditional Chinese medicine raw materials into 1.5 kg of clear water, soaking for 10-20 minutes, boiling with strong fire, continuously decocting for 20 minutes with slow fire, naturally cooling to room temperature, and filtering to obtain filtrate, namely a target product. The traditional Chinese medicines in the traditional Chinese medicine composition disclosed by the invention are compatible with one another and have a synergistic effect, so that replication and propagation of the norovirus can be effectively inhibited, and norovirus infection can be fundamentally treated.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and specifically refers to a traditional Chinese medicine composition for treating norovirus infection and its application. Background Art

[0002] Norovirus is a virus that causes non-bacterial acute gastroenteritis, and has characteristics such as fast transmission speed, low infectious dose, and long virus excretion time. The general population is susceptible. After being infected with norovirus, patients mainly show symptoms such as nausea, vomiting, diarrhea, and abdominal pain, which seriously affect the physical health and quality of life of patients.

[0003] At present, there is no specific antiviral drug for norovirus infection, and clinical treatment mainly focuses on symptomatic supportive treatment, such as fluid replacement and correction of electrolyte disorders, to relieve the symptoms of patients and promote physical recovery. However, these treatment methods can only relieve symptoms, cannot fundamentally inhibit the replication and transmission of the virus, and the treatment cycle is relatively long.

[0004] Traditional Chinese medicine, as a treasure of traditional Chinese medicine in our country, has unique advantages and rich experience in treating various diseases. In recent years, with the continuous in-depth research on traditional Chinese medicine, more and more traditional Chinese medicines have been found to have effects such as antiviral and immune regulation.

[0005] Therefore, it has important practical significance to develop a safe and effective traditional Chinese medicine composition for treating norovirus infection. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to overcome the above-mentioned technical defects and provide a traditional Chinese medicine composition for treating norovirus infection and its application.

[0007] To solve the above technical problem, the technical solution provided by the present invention is a traditional Chinese medicine composition for treating norovirus infection, which comprises the following raw materials in parts by weight: Poria cocos 6 g - 12 g, Alisma orientale 6 g - 12 g, Eupatorium fortunei 8 g - 15 g, Talc 10 g - 18 g, Pogostemon cablin 8 g - 12 g, Medicated leaven 5 g - 10 g, Aucklandia lappa 8 g - 12 g, Pueraria lobata 15 g - 25 g, Coptis chinensis 4 g - 8 g.

[0008] Further, it comprises the following raw materials in parts by weight: Poria cocos 6 g, Alisma orientale 6 g, Eupatorium fortunei 8 g, Talc 10 g, Pogostemon cablin 8 g, Medicated leaven 5 g, Aucklandia lappa 8 g, Pueraria lobata 15 g, Coptis chinensis 4 g.

[0009] Further, it comprises the following raw materials in parts by weight: Poria cocos 12 g, Alisma orientale 12 g, Eupatorium fortunei 15 g, Talc 18 g, Pogostemon cablin 12 g, Medicated leaven 10 g, Aucklandia lappa 12 g, Pueraria lobata 25 g, Coptis chinensis 8 g.

[0010] Further, the preparation method of the above traditional Chinese medicine composition comprises the following steps: taking each raw material by weight, adding the above traditional Chinese medicine raw materials into 1.5 kg of clear water, soaking for 10 - 20 minutes, boiling with strong fire, then changing to slow fire and continuing to boil for 20 minutes, naturally cooling to room temperature, and filtering. The obtained filtrate is the target product.

[0011] The second object of the present invention is to provide the application of the above traditional Chinese medicine composition in the preparation of a drug for treating norovirus infection diseases.

[0012] Further, the dosage form of the drug includes oral liquid, granule, and powder.

[0013] In the traditional Chinese medicine composition of the present invention, each medicinal material complements each other and jointly exerts the efficacy of treating norovirus infection. Poria cocos is sweet, light, and has a neutral nature. It belongs to the heart, lung, spleen, and kidney meridians, promoting diuresis to eliminate dampness, strengthening the spleen and calming the heart, and can effectively improve symptoms such as diarrhea and edema caused by water retention due to norovirus infection. Alisma orientale is sweet, light, and has a cold nature. It belongs to the kidney and bladder meridians, promoting diuresis to eliminate dampness and clearing heat, and synergizes with Poria cocos to enhance the power of promoting diuresis to eliminate dampness, helping the body excrete excess water and dampness, and relieving the state of damp turbidity blockage in the gastrointestinal tract caused by virus infection.

[0014] Eupatorium fortunei is pungent and has a neutral nature. It belongs to the spleen, stomach, and lung meridians, aromatizing dampness, waking up the spleen and promoting appetite, and relieving summer heat. Norovirus infection often impairs the functions of the spleen and stomach, resulting in endogenous damp turbidity. The aromatic property of Eupatorium fortunei can effectively eliminate damp turbidity in the spleen and stomach, restore the transportation and transformation functions of the spleen and stomach, and improve symptoms such as nausea, vomiting, and loss of appetite in patients. Talc is sweet, light, and has a cold nature. It belongs to the bladder, lung, and stomach meridians, promoting diuresis and relieving stranguria, clearing heat and relieving summer heat, and astringing dampness and promoting granulation. Its heat-clearing power can reduce the endogenous heat in the body caused by norovirus infection, and its diuretic effect helps relieve diarrhea symptoms and promote the excretion of waste in the body.

[0015] Agastache rugosa is pungent and has a slightly warm nature. It belongs to the spleen, stomach, and lung meridians, transforming dampness and waking up the spleen, dispelling foulness and regulating the middle, and relieving summer heat and promoting sweating. Agastache rugosa can not only transform damp turbidity but also stop vomiting, and has a good relieving effect on symptoms such as spleen and stomach damp turbidity and nausea and vomiting caused by norovirus infection. When combined with medicinal materials such as Eupatorium fortunei, it strengthens the efficacy of transforming dampness and regulating the stomach. Coptis chinensis is bitter and has a cold nature, clearing heat and drying dampness, purging fire and detoxifying; Pueraria lobata is sweet, pungent, and cool, belonging to the spleen and stomach meridians, promoting the rising of yang to stop diarrhea, dredging channels and collaterals, and detoxifying alcohol. Jianqu is sweet, pungent, and warm, belonging to the spleen and stomach meridians, promoting digestion and resolving food stagnation, strengthening the spleen and regulating the stomach. During norovirus infection, the functions of the spleen and stomach of patients are affected, and food stagnation often occurs. Jianqu can help with digestion, restore the normal transportation and transformation functions of the spleen and stomach, and reduce the burden on the gastrointestinal tract. Aucklandia lappa is pungent, bitter, and warm, belonging to the spleen, stomach, large intestine, triple energizer, and gallbladder meridians, promoting qi circulation to relieve pain, strengthening the spleen and promoting digestion. It can effectively relieve the abdominal pain symptoms caused by gastrointestinal qi stagnation due to norovirus infection, and at the same time assist the transportation and transformation of the spleen and stomach. When combined with Jianqu, etc., it improves the digestive function.

[0016] The advantages of the present invention compared with the prior art are as follows:

[0017] 1) The various traditional Chinese medicines in the traditional Chinese medicine composition of the present invention are mutually compatible and have a synergistic effect, which can effectively inhibit the replication and transmission of norovirus and fundamentally treat norovirus infection;

[0018] 2) The traditional Chinese medicine composition can significantly relieve clinical symptoms such as nausea, vomiting, diarrhea, abdominal pain, etc. caused by norovirus infection, relieve the pain of patients, and promote physical recovery;

[0019] 3) The traditional Chinese medicine composition of the present invention is made of natural traditional Chinese medicine raw materials, is safe and has no side effects, has a small burden on the patient's body, and is especially suitable for special populations such as the elderly and children;

[0020] 4) The preparation method of the traditional Chinese medicine composition of the present invention is simple and easy to implement, does not require complex equipment and processes, and is easy for industrial production. Detailed implementation mode

[0021] The following further elaborates on a traditional Chinese medicine composition for treating norovirus infection and its application according to the present invention in conjunction with embodiments.

[0022] Embodiment 1

[0023] A traditional Chinese medicine composition for treating norovirus infection, the preparation method thereof includes the following steps: Weigh 6 grams of Poria cocos, 6 grams of Alisma orientale, 8 grams of Eupatorium fortunei, 10 grams of Talc, 8 grams of Pogostemon cablin, 5 grams of Medicated leaven, 8 grams of Aucklandia lappa, 15 grams of Pueraria lobata, and 4 grams of Coptis chinensis. Add the above traditional Chinese medicine raw materials to 1.5 kilograms of clear water, soak for 10 minutes, then bring to a boil over high heat, and then change to low heat and continue to boil for 20 minutes. After naturally cooling to room temperature, filter to obtain a filtrate;

[0024] Concentrate the obtained filtrate, add appropriate flavoring agents and preservatives, stir evenly, and then fill into containers to obtain an oral liquid for treating norovirus infection.

[0025] Usage method: Take it three times a day, with an interval of four hours each time;

[0026] Precautions: Use with caution during pregnancy. Pay attention to rest during the medication period, try to eat white porridge, and can appropriately eat sugarcane to supplement energy in the middle.

[0027] Embodiment 2

[0028] A traditional Chinese medicine composition for treating norovirus infection, the preparation method thereof includes the following steps: Weigh 12 grams of Poria cocos, 12 grams of Alisma orientale, 15 grams of Eupatorium fortunei, 18 grams of Talc, 12 grams of Pogostemon cablin, 10 grams of Medicated leaven, 12 grams of Aucklandia lappa, 25 grams of Pueraria lobata, and 8 grams of Coptis chinensis. Add the above traditional Chinese medicine raw materials to 1.5 kilograms of clear water, soak for 20 minutes, then bring to a boil over high heat, and then change to low heat and continue to boil for 20 minutes. After naturally cooling to room temperature, filter to obtain a filtrate;

[0029] The obtained filtrate is concentrated and dried to form a dry extract. After the dry extract is pulverized, an appropriate amount of filler and flavoring agent are added to prepare granules.

[0030] Usage: Take it three times a day, at intervals of four hours each time;

[0031] Precautions: Use with caution during pregnancy. Pay attention to rest during medication. Try to eat white porridge and can eat an appropriate amount of sugarcane in the middle to supplement energy.

[0032] Example 3

[0033] A traditional Chinese medicine composition for treating norovirus infection, and its preparation method includes the following steps: Weigh 9 grams of Poria cocos, 9 grams of Alisma orientale, 12 grams of Eupatorium fortunei, 14 grams of Talcum, 10 grams of Pogostemon cablin, 7 grams of Medicated Leaven, 10 grams of Aucklandia lappa, 20 grams of Pueraria lobata, and 6 grams of Coptis chinensis. Add the above traditional Chinese medicine raw materials to 1.5 kilograms of clear water, soak for 15 minutes, then bring to a boil over high heat, and then change to low heat and continue to boil for 20 minutes. After naturally cooling to room temperature, filter to obtain a filtrate;

[0034] The obtained filtrate is spray-dried to form a powder.

[0035] Usage: Take it three times a day, at intervals of four hours each time;

[0036] Precautions: Use with caution during pregnancy. Pay attention to rest during medication. Try to eat white porridge and can eat an appropriate amount of sugarcane in the middle to supplement energy.

[0037] The above describes the present invention and its implementation manners, and this description is not restrictive. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the purpose of the present invention, design similar structural manners and embodiments to this technical solution without creative efforts, they shall fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating norovirus infection, characterized in that, It comprises the following raw materials in parts by weight: 6 g - 12 g of Poria cocos, 6 g - 12 g of Alisma orientale, 8 g - 15 g of Eupatorium fortunei, 10 g - 18 g of Talc, 8 g - 12 g of Pogostemon cablin, 5 g - 10 g of Jianqu (medicated leaven), 8 g - 12 g of Aucklandia lappa, 15 g - 25 g of Pueraria lobata, 4 g - 8 g of Coptis chinensis.

2. The traditional Chinese medicine composition according to claim 1, wherein It comprises the following raw materials in parts by weight: 6 g of Poria cocos, 6 g of Alisma orientale, 8 g of Eupatorium fortunei, 10 g of Talc, 8 g of Pogostemon cablin, 5 g of Jianqu (medicated leaven), 8 g of Aucklandia lappa, 15 g of Pueraria lobata, 4 g of Coptis chinensis.

3. The traditional Chinese medicine composition according to claim 1, wherein: It comprises the following raw materials in parts by weight: 12 g of Poria cocos, 12 g of Alisma orientale, 15 g of Eupatorium fortunei, 18 g of Talc, 12 g of Pogostemon cablin, 10 g of Jianqu (medicated leaven), 12 g of Aucklandia lappa, 25 g of Pueraria lobata, 8 g of Coptis chinensis.

4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, It includes the following steps: Take each raw material according to the parts by weight, add the above traditional Chinese medicine raw materials into 1.5 kg of clear water. After soaking for 10 - 20 minutes, bring to a boil over high heat, then turn to low heat and continue to boil for 20 minutes. After naturally cooling to room temperature, filter, and the obtained filtrate is the target product.

5. Use of the traditional Chinese medicine composition according to any one of claims 1 - 4 in the preparation of a drug for treating norovirus infection.

6. The application according to claim 5, wherein Dosage forms of the drug include oral liquid, granule, and powder.