Traditional Chinese medicine multi-component compound for treating multi-drug-resistant bacterium infection and application thereof

Abstract

The invention relates to a traditional Chinese medicine multi-component compound for treating multi-drug-resistant bacterium infection and application thereof. Comprising the following components in parts by weight: 5-10 parts of honeysuckle, 5-10 parts of scutellaria baicalensis, 3-8 parts of coptis chinensis, 5-10 parts of fructus forsythiae, 5-10 parts of dandelion, 3-7 parts of polygala tenuifolia, 5-12 parts of spina date seed, 3-9 parts of platycladi seed, 3-7 parts of cortex albiziae, 5-12 parts of tuber fleeceflower stem, 3-9 parts of salvia miltiorrhiza, 3-7 parts of rhizoma acori graminei, 5-10 parts of poria cocos, 3-6 parts of nacre mother of pearl, 3-6 parts of dragon bone, 3-6 parts of magnet, 3-7 parts of albizia flower, 3-8 parts of lucid ganoderma, 3-8 parts of lily and 3-8 parts of lotus seed. The medicine has the effects of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation. The components have a synergistic effect, not only can directly inhibit the growth of the drug-resistant bacteria, but also can improve the clearing ability of the body to the drug-resistant bacteria by regulating the immune function of the body, enhancing the activity of macrophages and T lymphocytes and enhancing the non-specific immunity and the specific immunity of the body, and the formula is beneficial to relieving the symptoms of drug-resistant bacteria infection, so that the drug-resistant bacteria can be prevented from being infected by the drug-resistant bacteria. The disease recovery is accelerated.

Description

Technical Field

[0001] The present invention relates to the technical field of drug-resistant bacteria treatment, and specifically to a multi-component traditional Chinese medicine compound for treating multi-drug resistant bacteria infection and its application. Background Art

[0002] Antibacterial drugs refer to drugs used to treat infectious diseases caused by pathogenic microorganisms such as bacteria, mycoplasma, chlamydia, rickettsia, spirochetes, and fungi;

[0003] Drug-resistant bacteria infection means that the pathogenic bacteria develop drug resistance to the treatment drugs, resulting in the inability of antibacterial drugs to effectively treat the infection of pathogenic bacteria;

[0004] With the widespread application of antibacterial drugs, the problem of bacterial drug resistance has become increasingly serious. Multi-drug resistant bacteria infection has become a major challenge to global public health. Traditional single antibiotic treatment methods often have poor effects when facing multi-drug resistant bacteria and are prone to further upgrading of bacterial drug resistance;

[0005] A multi-component traditional Chinese medicine compound refers to a compound preparation composed of multiple traditional Chinese medicinal materials combined in a certain proportion, with the characteristics of complex components, diverse action mechanisms, and definite curative effects. In traditional Chinese medicine theory, multi-drug resistant bacteria infection is often related to the excessive presence of pathogenic fire and toxin in the body, while the multi-component traditional Chinese medicine compound can effectively regulate the internal environment and inhibit the growth and reproduction of pathogenic bacteria through various ways such as clearing heat and resolving phlegm, purging fire and detoxifying;

[0006] Therefore, we propose a multi-component traditional Chinese medicine compound for treating multi-drug resistant bacteria infection and its application. Summary of the Invention

[0007] The purpose of the present invention is to provide a multi-component traditional Chinese medicine compound for treating multi-drug resistant bacteria infection and its application, and solve the problems raised in the background art.

[0008] To achieve the above purpose, the present invention provides the following technical solution: A multi-component traditional Chinese medicine compound for treating multi-drug resistant bacteria infection, including the following weight components:

[0009] 5 - 10 parts of Flos Lonicerae, 5 - 10 parts of Radix Scutellariae, 3 - 8 parts of Rhizoma Coptidis, 5 - 10 parts of Fructus Forsythiae, 5 - 10 parts of Herba Taraxaci, 3 - 7 parts of Radix Polygalae, 5 - 12 parts of Semen Ziziphi Spinosae, 3 - 9 parts of Semen Platycladi, 3 - 7 parts of Cortex Albiziae, 5 - 12 parts of Caulis Polygoni Multiflori, 3 - 9 parts of Radix Salviae Miltiorrhizae, 3 - 7 parts of Rhizoma Acori Tatarinowii, 5 - 10 parts of Poria, 3 - 6 parts of Concha Margaritifera Usta, 3 - 6 parts of Os Draconis, 3 - 6 parts of Magnetitum, 3 - 7 parts of Flos Albiziae, 3 - 8 parts of Ganoderma lucidum, 3 - 8 parts of Bulbus Lilii, 3 - 8 parts of Semen Nelumbinis.

[0010] As a preferred embodiment of the present invention, it includes the following weight components:

[0011] 5 parts of honeysuckle, 5 parts of skullcap root, 3 parts of coptis root, 5 parts of forsythia fruit, 5 parts of dandelion, 3 parts of polygala root, 5 parts of wild jujube seed, 3 parts of semen platycladi, 3 parts of cortex albiziae, 5 parts of polygonum multiflorum thunb, 3 parts of salvia miltiorrhiza, 3 parts of acorus tatarinowii, 5 parts of poria cocos, 3 parts of margarita, 3 parts of fossil fragments, 3 parts of magnetite, 3 parts of albizia flower, 3 parts of ganoderma lucidum, 3 parts of lily bulb, 3 parts of lotus seed.

[0012] As a preferred embodiment of the present invention, it includes the following weight components:

[0013] 6 parts of honeysuckle, 7 parts of skullcap root, 5 parts of coptis root, 7 parts of forsythia fruit, 7 parts of dandelion, 4 parts of polygala root, 7 parts of wild jujube seed, 5 parts of semen platycladi, 4 parts of cortex albiziae, 7 parts of polygonum multiflorum thunb, 5 parts of salvia miltiorrhiza, 4 parts of acorus tatarinowii, 7 parts of poria cocos, 4 parts of margarita, 4 parts of fossil fragments, 4 parts of magnetite, 4 parts of albizia flower, 4 parts of ganoderma lucidum, 4 parts of lily bulb, 4 parts of lotus seed.

[0014] As a preferred embodiment of the present invention, it includes the following weight components:

[0015] 7 parts of honeysuckle, 8 parts of skullcap root, 6 parts of coptis root, 8 parts of forsythia fruit, 8 parts of dandelion, 5 parts of polygala root, 9 parts of wild jujube seed, 6 parts of semen platycladi, 5 parts of cortex albiziae, 9 parts of polygonum multiflorum thunb, 6 parts of salvia miltiorrhiza, 5 parts of acorus tatarinowii, 8 parts of poria cocos, 5 parts of margarita, 5 parts of fossil fragments, 5 parts of magnetite, 5 parts of albizia flower, 5 parts of ganoderma lucidum, 5 parts of lily bulb, 5 parts of lotus seed.

[0016] As a preferred embodiment of the present invention, it includes the following weight components:

[0017] 8 parts of honeysuckle, 9 parts of skullcap root, 7 parts of coptis root, 9 parts of forsythia fruit, 9 parts of dandelion, 6 parts of polygala root, 11 parts of wild jujube seed, 7 parts of semen platycladi, 6 parts of cortex albiziae, 11 parts of polygonum multiflorum thunb, 7 parts of salvia miltiorrhiza, 6 parts of acorus tatarinowii, 9 parts of poria cocos, 5 parts of margarita, 5 parts of fossil fragments, 5 parts of magnetite, 6 parts of albizia flower, 6 parts of ganoderma lucidum, 6 parts of lily bulb, 6 parts of lotus seed.

[0018] As a preferred embodiment of the present invention, it includes the following weight components:

[0019] 10 parts of honeysuckle, 10 parts of skullcap root, 8 parts of coptis root, 10 parts of forsythia fruit, 10 parts of dandelion, 7 parts of polygala root, 12 parts of wild jujube seed, 9 parts of semen platycladi, 7 parts of cortex albiziae, 12 parts of polygonum multiflorum thunb, 9 parts of salvia miltiorrhiza, 7 parts of acorus tatarinowii, 10 parts of poria cocos, 6 parts of margarita, 6 parts of fossil fragments, 6 parts of magnetite, 7 parts of albizia flower, 8 parts of ganoderma lucidum, 8 parts of lily bulb, 8 parts of lotus seed.

[0020] The present invention also relates to the application of a multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections, and this multi-component traditional Chinese medicine compound is used to treat multi-drug resistant bacterial infection diseases.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0022] 1. The present invention has the effects of clearing heat and detoxifying, and antibacterial and anti-inflammatory. They can act synergistically, not only directly inhibiting the growth of drug-resistant bacteria, but also enhancing the activity of macrophages and T lymphocytes by regulating the body's immune function, improving the body's ability to clear drug-resistant bacteria. By enhancing the body's non-specific and specific immunity, this formula helps to alleviate the symptoms of drug-resistant bacteria infection and accelerate the recovery of the condition;

[0023] 2. The present invention has the functions of calming the nerves and promoting sleep, and regulating the nervous system. It can improve the body's stress state, reduce the excessive inflammatory response caused by infection, thereby maintaining the balance of the body's microecology. In addition, these medicinal materials can also promote the health of the intestinal flora, reduce the production of drug-resistant bacteria caused by intestinal flora imbalance. By regulating the balance of the body's microecology, this formula helps to prevent the further spread of drug-resistant bacteria and the aggravation of infection;

[0024] 3. The present invention has various effects such as calming the nerves and improving intelligence, sedating the nerves, promoting blood circulation to remove blood stasis, strengthening the spleen and promoting diuresis. It can comprehensively regulate the overall condition of the body, improve the systemic symptoms caused by drug-resistant bacteria infection. By improving the overall condition of the body, this formula helps to improve the patient's tolerance and compliance to the treatment of drug-resistant bacteria, thereby increasing the success rate of treatment. Specific Embodiments

[0025] In order to make the technical means, creative features, achieved purposes and effects of the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0026] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention; in the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "connected", "set" should be understood in a broad sense. For example, it can be fixedly connected and set, or detachably connected and set, or integrally connected and set. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0027] The present invention provides a technical solution: a multi-component traditional Chinese medicine compound for treating multi-drug resistant bacteria infection, comprising the following weight components:

[0028] 5 - 10 parts of honeysuckle, 5 - 10 parts of skullcap root, 3 - 8 parts of coptis root, 5 - 10 parts of forsythia fruit, 5 - 10 parts of dandelion, 3 - 7 parts of polygala root, 5 - 12 parts of wild jujube seed, 3 - 9 parts of semen platycladi, 3 - 7 parts of cortex albiziae, 5 - 12 parts of polygonum multiflorum thunb, 3 - 9 parts of salvia miltiorrhiza, 3 - 7 parts of acorus tatarinowii, 5 - 10 parts of poria cocos, 3 - 6 parts of mother-of-pearl, 3 - 6 parts of dragon bone, 3 - 6 parts of magnetite, 3 - 7 parts of albizia flower, 3 - 8 parts of ganoderma lucidum, 3 - 8 parts of lily bulb, 3 - 8 parts of lotus seed.

[0029] Preparation method:

[0030] Step 1: Gently rinse the weighed medicinal materials with flowing clear water to remove the dust and impurities on the surface. After cleaning, put the medicinal materials into an appropriate amount of cold water and soak them. Generally, the soaking time is 2 - 4 hours to make the medicinal materials fully absorb water and expand.

[0031] Step 2: Chop the larger pieces of medicinal materials.

[0032] Step 3: Put the soaked medicinal materials together with the soaking liquid into a decocting pot, add an appropriate amount of water, bring to a boil over high heat and then turn to low heat for decocting for 1 - 2 hours. Stir during the decocting process to prevent sticking to the pot. After the decocting is completed, filter out the medicinal residues with a gauze or strainer to obtain the first decocted liquid. Add an appropriate amount of water to the medicinal residues again and repeat the above decocting process to obtain the second decocted liquid. Combine the two decocted liquids to obtain the compound extract.

[0033] Step 4: Place the compound extract in an evaporating dish and concentrate it over a gentle fire to the required concentration. Then make the concentrated medicinal liquid into oral liquid.

[0034] Example 1

[0035] 5 parts of honeysuckle, 5 parts of skullcap root, 3 parts of coptis root, 5 parts of forsythia fruit, 5 parts of dandelion, 3 parts of polygala root, 5 parts of wild jujube seed, 3 parts of semen platycladi, 3 parts of cortex albiziae, 5 parts of polygonum multiflorum thunb, 3 parts of salvia miltiorrhiza, 3 parts of acorus tatarinowii, 5 parts of poria cocos, 3 parts of mother-of-pearl, 3 parts of dragon bone, 3 parts of magnetite, 3 parts of albizia flower, 3 parts of ganoderma lucidum, 3 parts of lily bulb, 3 parts of lotus seed;

[0036] Prepare the above medicinal materials into oral liquid according to the preparation method.

[0037] Example 2

[0038] 6 parts of honeysuckle, 7 parts of skullcap root, 5 parts of coptis root, 7 parts of forsythia fruit, 7 parts of dandelion, 4 parts of polygala root, 7 parts of wild jujube seed, 5 parts of semen platycladi, 4 parts of cortex albiziae, 7 parts of polygonum multiflorum thunb, 5 parts of salvia miltiorrhiza, 4 parts of acorus tatarinowii, 7 parts of poria cocos, 4 parts of mother-of-pearl, 4 parts of dragon bone, 4 parts of magnetite, 4 parts of albizia flower, 4 parts of ganoderma lucidum, 4 parts of lily bulb, 4 parts of lotus seed;

[0039] Prepare the above medicinal materials into oral liquid according to the preparation method.

[0040] Embodiment 3

[0041] 7 parts of honeysuckle, 8 parts of scutellaria, 6 parts of coptis, 8 parts of forsythia, 8 parts of dandelion, 5 parts of polygala, 9 parts of spiny jujube seeds, 6 parts of cypress seeds, 5 parts of julibrissin bark, 9 parts of smilax china, 6 parts of salvia miltiorrhiza, 5 parts of calamus, 8 parts of poria, 5 parts of mother-of-pearl, 5 parts of dragon bones, 5 parts of magnetite, 5 parts of julibrissin flowers, 5 parts of ganoderma, 5 parts of lily, and 5 parts of lotus seeds;

[0042] The above medicinal materials can be used to prepare oral liquid according to the preparation method.

[0043] Embodiment 4

[0044] 8 parts of honeysuckle, 9 parts of scutellaria, 7 parts of coptis root, 9 parts of forsythia, 9 parts of dandelion, 6 parts of polygala, 11 parts of spiny jujube seeds, 7 parts of cypress seeds, 6 parts of julibrissin bark, 11 parts of smilax china, 7 parts of salvia miltiorrhiza, 6 parts of calamus, 9 parts of poria, 5 parts of mother-of-pearl, 5 parts of dragon bone, 5 parts of magnetite, 6 parts of julibrissin flower, 6 parts of ganoderma lucidum, 6 parts of lily, and 6 parts of lotus seeds;

[0045] The above medicinal materials can be used to prepare oral liquid according to the preparation method.

[0046] Embodiment 5

[0047] 10 parts of honeysuckle, 10 parts of scutellaria, 8 parts of coptis, 10 parts of forsythia, 10 parts of dandelion, 7 parts of polygala, 12 parts of spiny jujube seeds, 9 parts of cypress seeds, 7 parts of julibrissin bark, 12 parts of smilax china, 9 parts of salvia miltiorrhiza, 7 parts of calamus, 10 parts of poria, 6 parts of mother-of-pearl, 6 parts of dragon bones, 6 parts of magnetite, 7 parts of julibrissin, 8 parts of ganoderma, 8 parts of lily, and 8 parts of lotus seeds;

[0048] The above medicinal materials can be used to prepare oral liquid according to the preparation method.

[0049] The Chinese medicines prepared in the above five embodiments were used in clinical trials, and the effects were as follows:

[0050] Example Bacteriostatic rate or improvement rate Example 1 30％ Example 2 50％ Example 3 60％ Example 4 75％ Example 5 90％

[0051] In summary, the formula of Example 5 has the best therapeutic effect, and has the effects of clearing away heat and detoxifying, and antibacterial and anti-inflammatory. They can work synergistically, not only directly inhibiting the growth of drug-resistant bacteria, but also regulating the body's immune function, enhancing the activity of macrophages and T lymphocytes, and improving the body's ability to eliminate drug-resistant bacteria. By enhancing the body's nonspecific immunity and specific immunity, this formula helps to alleviate the symptoms of drug-resistant bacteria infection and accelerate recovery from the disease.

[0052] The foregoing has shown and described the basic principles, main features and advantages of the present invention. For a person skilled in the art, it is obvious that the present invention is not limited to the details of the above-mentioned exemplary embodiments, and without departing from the spirit or basic features of the present invention, the present invention can be implemented in other specific forms. Therefore, in any regard, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, it is intended to embrace all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention. Any reference signs in the claims should not be construed as limiting the claim concerned.

[0053] In addition, it should be understood that although this specification is described in terms of embodiments, not every embodiment only contains an independent technical solution. This narrative manner of the specification is only for clarity. A person skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by a person skilled in the art.

Claims

1. A traditional Chinese medicine multi-component compound for treating multi-drug resistant bacterial infections, characterized in that: It comprises the following weight components: 5 - 10 parts of Flos Lonicerae, 5 - 10 parts of Radix Scutellariae, 3 - 8 parts of Rhizoma Coptidis, 5 - 10 parts of Fructus Forsythiae, 5 - 10 parts of Herba Taraxaci, 3 - 7 parts of Radix Polygalae, 5 - 12 parts of Semen Ziziphi Spinosae, 3 - 9 parts of Semen Platycladi, 3 - 7 parts of Cortex Albiziae, 5 - 12 parts of Caulis Polygoni Multiflori, 3 - 9 parts of Radix Salviae Miltiorrhizae, 3 - 7 parts of Rhizoma Acori Tatarinowii, 5 - 10 parts of Poria, 3 - 6 parts of Concha Margaritifera Usta, 3 - 6 parts of Os Draconis, 3 - 6 parts of Magnetitum, 3 - 7 parts of Flos Albiziae, 3 - 8 parts of Ganoderma lucidum, 3 - 8 parts of Bulbus Lilii, 3 - 8 parts of Semen Nelumbinis 2. The multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to claim 1, wherein: It comprises the following weight components: 5 parts of Flos Lonicerae, 5 parts of Radix Scutellariae, 3 parts of Rhizoma Coptidis, 5 parts of Fructus Forsythiae, 5 parts of Herba Taraxaci, 3 parts of Radix Polygalae, 5 parts of Semen Ziziphi Spinosae, 3 parts of Semen Platycladi, 3 parts of Cortex Albiziae, 5 parts of Caulis Polygoni Multiflori, 3 parts of Radix Salviae Miltiorrhizae, 3 parts of Rhizoma Acori Tatarinowii, 5 parts of Poria, 3 parts of Concha Margaritifera Usta, 3 parts of Os Draconis, 3 parts of Magnetitum, 3 parts of Flos Albiziae, 3 parts of Ganoderma lucidum, 3 parts of Bulbus Lilii, 3 parts of Semen Nelumbinis 3. The multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to claim 1, wherein: It comprises the following weight components: 6 parts of Flos Lonicerae, 7 parts of Radix Scutellariae, 5 parts of Rhizoma Coptidis, 7 parts of Fructus Forsythiae, 7 parts of Herba Taraxaci, 4 parts of Radix Polygalae, 7 parts of Semen Ziziphi Spinosae, 5 parts of Semen Platycladi, 4 parts of Cortex Albiziae, 7 parts of Caulis Polygoni Multiflori, 5 parts of Radix Salviae Miltiorrhizae, 4 parts of Rhizoma Acori Tatarinowii, 7 parts of Poria, 4 parts of Concha Margaritifera Usta, 4 parts of Os Draconis, 4 parts of Magnetitum, 4 parts of Flos Albiziae, 4 parts of Ganoderma lucidum, 4 parts of Bulbus Lilii, 4 parts of Semen Nelumbinis 4. The multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to claim 1, wherein: It comprises the following weight components: 7 parts of Flos Lonicerae, 8 parts of Radix Scutellariae, 6 parts of Rhizoma Coptidis, 8 parts of Fructus Forsythiae, 8 parts of Herba Taraxaci, 5 parts of Radix Polygalae, 9 parts of Semen Ziziphi Spinosae, 6 parts of Semen Platycladi, 5 parts of Cortex Albiziae, 9 parts of Caulis Polygoni Multiflori, 6 parts of Radix Salviae Miltiorrhizae, 5 parts of Rhizoma Acori Tatarinowii, 8 parts of Poria, 5 parts of Concha Margaritifera Usta, 5 parts of Os Draconis, 5 parts of Magnetitum, 5 parts of Flos Albiziae, 5 parts of Ganoderma lucidum, 5 parts of Bulbus Lilii, 5 parts of Semen Nelumbinis 5. The multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to claim 1, wherein: It comprises the following weight components: 8 parts of Flos Lonicerae, 9 parts of Radix Scutellariae, 7 parts of Rhizoma Coptidis, 9 parts of Fructus Forsythiae, 9 parts of Herba Taraxaci, 6 parts of Radix Polygalae, 11 parts of Semen Ziziphi Spinosae, 7 parts of Semen Platycladi, 6 parts of Cortex Albiziae, 11 parts of Caulis Polygoni Multiflori, 7 parts of Radix Salviae Miltiorrhizae, 6 parts of Rhizoma Acori Tatarinowii, 9 parts of Poria, 5 parts of Concha Margaritifera Usta, 5 parts of Os Draconis, 5 parts of Magnetitum, 6 parts of Flos Albiziae, 6 parts of Ganoderma lucidum, 6 parts of Bulbus Lilii, 6 parts of Semen Nelumbinis 6. The multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to claim 1, wherein: It comprises the following weight components: 10 parts of Flos Lonicerae, 10 parts of Radix Scutellariae, 8 parts of Rhizoma Coptidis, 10 parts of Fructus Forsythiae, 10 parts of Herba Taraxaci, 7 parts of Radix Polygalae, 12 parts of Semen Ziziphi Spinosae, 9 parts of Semen Platycladi, 7 parts of Cortex Albiziae, 12 parts of Caulis Polygoni Multiflori, 9 parts of Radix Salviae Miltiorrhizae, 7 parts of Rhizoma Acori Tatarinowii, 10 parts of Poria, 6 parts of Concha Margaritifera Usta, 6 parts of Os Draconis, 6 parts of Magnetitum, 7 parts of Flos Albiziae, 8 parts of Ganoderma lucidum, 8 parts of Bulbus Lilii, 8 parts of Semen Nelumbinis 7. Use of the multi-component traditional Chinese medicine compound for treating multi-drug resistant bacterial infections according to any one of claims 1-6, characterized in that: This multi - component traditional Chinese medicine compound is used for treating multi - drug resistant bacterial infection diseases.