Spleen-invigorating and dampness-eliminating composition as well as preparation method and application thereof

Abstract

The invention provides a spleen invigorating and dampness eliminating composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines and traditional Chinese medicine beverages. The invention provides a spleen-invigorating and dampness-eliminating composition. The spleen-invigorating and dampness-eliminating composition comprises ginseng, astragalus membranaceus, poria cocos and fried coix seeds. According to the spleen-tonifying and dampness-eliminating composition, the weight-losing composition is prepared from ginseng, astragalus membranaceus, poria cocos and fried coix seeds according to the principles of tonifying qi, tonifying spleen and eliminating dampness aiming at yin pathogen coagulation caused by qi deficiency and spleen weakness which are root causes of obesity, the astragalus membranaceus is used as a monarch drug, and the ginseng, the poria cocos and the fried coix seeds are used as ministerial drugs, so that the effects of tonifying qi, tonifying spleen and eliminating dampness are achieved; the problems of obesity, constipation and the like caused by weakness of the spleen and the stomach can be fundamentally solved. Aiming at the root cause of obesity, the spleen-invigorating and dampness-eliminating composition provided by the invention has the advantages of simple formula, simple preparation process and capability of being taken for a long time; in-vivo fat can be controlled, and the health level of blood fat (cholesterol / triglyceride) can be maintained.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine and traditional Chinese medicine beverages, and particularly relates to a spleen-strengthening and dampness-resolving composition, a preparation method thereof, and an application thereof. Background Art

[0002] Obesity is a chronic metabolic disease. In recent years, the global overweight and obesity rates have been growing rapidly and have become a serious problem threatening human health. Obesity not only leads to a higher risk of premature death, but is also associated with the occurrence of various chronic non-communicable diseases, including type 2 diabetes, stroke, coronary heart disease, hypertension, respiratory diseases, osteoarthritis, and gallstones. Therefore, the prevention and control of obesity is urgent.

[0003] Western medicine believes that obesity is a chronic metabolic disease caused by excessive accumulation or uneven distribution of body fat. Traditional Chinese medicine believes that the main pathogenesis of obesity is spleen qi deficiency leading to phlegm-dampness, phlegm-turbidity, and blood stasis; the disease location involves the middle jiao spleen and stomach, and is related to the kidney, lung, and triple energizer, and can affect the whole body's zang-fu organs. "Jingyue Quanshu · Miscellaneous Syndromes · Non-Wind" believes that fat people are mostly qi-deficient. Qi deficiency is the root cause of obesity and the key to the pathogenesis of obesity. The constitution of obese patients is mostly yang-deficient, that is, "yang transforming qi" is insufficient, and the distribution and dispersion of the essence of water and grains are abnormal, resulting in the aggregation of yin pathogens such as phlegm-fluid and damp-turbidity, staying between the muscles and skin, thus forming obesity. "Treatise on Febrile and Miscellaneous Diseases" points out: "The spleen is the source of qi and blood transformation, and the earth is the mother of all things." "Medical Compendium" points out: "The spleen and stomach are in the middle jiao and are the hub of the ascending and descending of the upper and lower." As the acquired foundation, the source of qi and blood transformation, and the pivot of qi movement, when the spleen qi is sufficient, qi and blood can be transformed, the ascending and descending, entering and exiting can be smooth, qi movement can be regulated, qi, blood, essence, and fluid will not stagnate, and blood stasis and turbid qi will not accumulate inside; on the contrary, when qi transformation is insufficient, "if the entry and exit are abolished, the spiritual mechanism will be destroyed; if the ascending and descending cease, qi will be in danger alone", water-dampness and phlegm-fluid will be congested, the spleen will not disperse essence and will fail to transport, and the body's fluid distribution will be abnormal, resulting in phlegm-fluid and water-dampness. Phlegm-fluid and water-dampness accumulate between the tendons, bones, chest, and abdomen, and over time can turn into "fatty substances" and "phlegm-turbidity". As stated in "Plain Questions · Meridian Collateral Theory": "Drinking enters the stomach, diffuses the essence, and is transported upward to the spleen; the spleen qi disperses the essence and returns it upward to the lung; the lung regulates water passages and transports it downward to the bladder. The essence of water is distributed everywhere, and the five classics function together, in harmony with the four seasons, five zang-organs, yin and yang, and measured as normal." The physiological process of water metabolism involves the spleen, lung, liver, kidney, and triple energizer, etc. The spleen transports and disperses body fluids, the lung disperses and descends to promote water circulation, the kidney promotes qi transformation, the liver dredges and regulates water, and the triple energizer regulates water passage and promotes diuresis, none of which can be lacking.

[0004] With the increasing improvement of people's living standards and the continuous change of production and lifestyle, more and more people become obese because they are busy with work and study and neglect exercise; obesity is likely to cause various diseases such as hypertension, diabetes, and fatty liver, which not only affect beauty but also seriously threaten people's physical health.

[0005] At present, there are many drugs for weight loss on the market. However, most of the drugs for treating obesity are traditional Chinese medicine compositions so far. Although some of these traditional Chinese medicine compositions can produce certain effects, since the components added to the drugs do not belong to the raw materials of both medicine and food, they are not suitable for long-term use. And some weight loss drugs also have problems such as complicated preparation processes, complex ingredients, and significant side effects.

[0006] Therefore, it is of great significance to provide a weight loss product that is safe, has no side effects, and is suitable for long-term use. Summary of the Invention

[0007] Aiming at the defects in the prior art, the purpose of the present invention is to provide a spleen-strengthening and dampness-resolving composition, which can be applied to weight loss and can be taken for a long time.

[0008] The purpose of the present invention is achieved by the following technical solutions:

[0009] The present invention provides a spleen-strengthening and dampness-resolving composition, which includes, by mass:

[0010] 0-10 parts of ginseng, 1-10 parts of astragalus membranaceus, 1-10 parts of poria cocos, and 1-10 parts of stir-fried coix seeds.

[0011] Preferably, the spleen-strengthening and dampness-resolving composition, by mass, includes:

[0012] 0-5 parts of ginseng, 5-10 parts of astragalus membranaceus, 1-5 parts of poria cocos, and 1-5 parts of stir-fried coix seeds;

[0013] or, 5-7 parts of ginseng, 1-5 parts of astragalus membranaceus, 5-10 parts of poria cocos, and 5-10 parts of stir-fried coix seeds;

[0014] or, 6-10 parts of astragalus membranaceus, 5-10 parts of poria cocos, and 1-5 parts of stir-fried coix seeds.

[0015] or, 0-5 parts of ginseng, 5-10 parts of astragalus membranaceus, 5-10 parts of poria cocos, and 1-5 parts of stir-fried coix seeds.

[0016] Preferably, the spleen-strengthening and dampness-resolving composition, by mass, includes:

[0017] 0.5 part of ginseng, 1 part of astragalus membranaceus, 1 part of poria cocos, and 1 part of stir-fried coix seeds.

[0018] The present invention provides a preparation method of the spleen-strengthening and dampness-resolving composition described in the above technical solution, including the following steps:

[0019] Soak astragalus membranaceus, poria cocos, and stir-fried coix seeds in water, and then carry out the first decoction to obtain the first decoction liquid and the medicinal residues;

[0020] Decoct the medicinal residues in water to obtain the second decoction liquid;

[0021] When ginseng is not included, the first decoction and the second decoction are mixed to obtain the spleen-strengthening and dampness-resolving composition.

[0022] When ginseng is included, the first decoction, the second decoction and the ginseng decoction are mixed to obtain the spleen-strengthening and dampness-resolving composition.

[0023] Preferably, when soaking astragalus membranaceus, poria cocos and stir-fried coix seeds in water, the addition amount of water is 10 to 50 times the mass of astragalus membranaceus, poria cocos and stir-fried coix seeds; the soaking time is 30 to 120 min; the temperature of each decoction is 90 to 100 °C; the time of each decoction is 20 to 40 min.

[0024] Preferably, the preparation method of the ginseng decoction includes the following steps:

[0025] Soak ginseng in water and then decoct to obtain the first ginseng decoction and ginseng residues;

[0026] Add water to the ginseng residues and decoct again to obtain the second ginseng decoction;

[0027] Mix the first ginseng decoction and the second ginseng decoction to obtain the ginseng decoction.

[0028] Preferably, when soaking ginseng in water, the addition amount of water is 10 to 30 times the mass of ginseng; the soaking time of ginseng is 30 to 120 min; when decocting ginseng, the temperature of each decoction is 90 to 100 °C; the time of each decoction is 20 to 40 min.

[0029] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of the following products (1) to (9):

[0030] (1) Spleen-strengthening and dampness-resolving products;

[0031] (2) Products helpful for controlling body fat;

[0032] (3) Products for weight loss and / or controlling body fat;

[0033] (4) Helpful for maintaining a healthy blood lipid level;

[0034] (5) Products for preventing and / or treating hyperlipidemia;

[0035] (6) Having an adjuvant effect on liver injury;

[0036] (7) Products for preventing and / or treating liver injury;

[0037] (8) Products for preventing and / or treating constipation;

[0038] (9) Products for moistening the intestines and relieving constipation.

[0039] Preferably, the product includes medicines and / or health products; the product includes beverages and / or tea drinks.

[0040] Advantages of the present invention

[0041] The present invention provides a spleen-strengthening and dampness-resolving composition, which, calculated by mass parts, includes: 0-10 parts of ginseng, 1-10 parts of astragalus membranaceus, 1-10 parts of poria cocos, and 1-10 parts of stir-fried coix seeds. In the present invention, the spleen-strengthening and dampness-resolving composition aims at the root causes of obesity, namely qi deficiency and spleen weakness leading to the aggregation of yin pathogens such as phlegm retention and damp turbidity. According to the principles of supplementing qi, strengthening the spleen, and resolving dampness, ginseng, astragalus membranaceus, poria cocos, and stir-fried coix seeds are selected to prepare a weight-loss composition as a traditional Chinese medicine preparation or a traditional Chinese medicine tea drink. Among them, astragalus membranaceus is used as the monarch drug, and ginseng, poria cocos, and stir-fried coix seeds are used as the ministerial drugs, jointly achieving the effects of supplementing qi, strengthening the spleen, and resolving dampness, and can fundamentally solve the problem of obesity, help control body fat, and achieve the effects of weight loss and controlling body fat. The spleen-strengthening and dampness-resolving composition provided by the present invention aims at the root causes of obesity, and has the advantages of simple formula (only four herbs), simple preparation process (low processing cost), and can be taken for a long time (no side effects), and can play a significant role in the treatment of obesity. Further, the spleen-strengthening and dampness-resolving composition provided by the present invention helps to maintain the blood lipid level in the body and can prevent and / or treat hyperlipidemia. The spleen-strengthening and dampness-resolving composition provided by the present invention also has an adjuvant effect on dry injury and can prevent and treat liver injury. The spleen-strengthening and dampness-resolving composition provided by the present invention also has the effect of moistening the intestines and relieving constipation and can effectively prevent and treat constipation. Description of the drawings

[0042] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required to be used in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0043] Figure 1 It is the total feed consumption diagram of rats in each test group of Application Example 2;

[0044] Figure 2 It is the weekly body weight growth rate diagram of each rat in each test group of Application Example 2;

[0045] Figure 3 It is the cumulative body weight growth rate diagram of rats in each test group of Application Example 2;

[0046] Figure 4 It is the diagram of the change in body length of each rat in each test group of Application Example 2;

[0047] Figure 5It is a graph showing the changes in the body width of each rat in each test group of Application Example 2;

[0048] Figure 6 It is a graph showing the test results of the serum TC index of each test group of Application Example 2;

[0049] Figure 7 It is a graph showing the test results of the serum TG index of each test group of Application Example 2;

[0050] Figure 8 It is a graph showing the test results of the serum LDL-C index of each test group of Application Example 2;

[0051] Figure 9 It is a graph showing the test results of the serum HDL-C index of each test group of Application Example 2;

[0052] Figure 10 It is a graph showing the test results of the serum ALT index of each test group of Application Example 2. Detailed implementation manners

[0053] The present invention provides a spleen-strengthening and dampness-resolving composition, which includes, by mass parts:

[0054] 0 - 10 parts of ginseng, 1 - 10 parts of astragalus membranaceus, 1 - 10 parts of poria cocos, and 1 - 10 parts of stir-fried coix seeds.

[0055] In the following technical solutions, unless otherwise specified, the present invention has no special limitation on the sources of each raw material, and conventional commercially available products in the art can be used.

[0056] By mass parts, the spleen-strengthening and dampness-resolving composition provided by the present invention includes 0 - 10 parts of ginseng. In the specific implementation manners of the present invention, the ginseng in the spleen-strengthening and dampness-resolving composition can be 0 part, or 0.5 - 10 parts, specifically can be 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts. In the present invention, the ginseng is of mild nature, sweet and slightly bitter in taste, slightly warm; it belongs to the spleen and lung meridians; it has the effects of greatly tonifying qi, restoring pulse and arresting collapse, invigorating the spleen and benefiting the lung.

[0057] Based on the mass parts of ginseng, the spleen-strengthening and dampness-resolving composition provided by the present invention includes 1 - 10 parts of astragalus membranaceus. In the specific implementation manners of the present invention, the astragalus membranaceus in the spleen-strengthening and dampness-resolving composition can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts. In the present invention, the astragalus membranaceus is sweet in taste and slightly warm in nature; it belongs to the lung, spleen, liver and kidney meridians; it has the effects of replenishing middle qi, promoting diuresis and relieving edema, and securing the exterior and arresting sweating.

[0058] Based on the parts by mass of ginseng, the spleen-strengthening and dampness-resolving composition provided by the present invention includes 1 to 10 parts of Poria cocos. In the specific embodiments of the present invention, the Poria cocos in the spleen-strengthening and dampness-resolving composition can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts. In the present invention, Poria cocos has a sweet, light and neutral taste; it belongs to the heart, lung, spleen and kidney meridians; and it has the effects of promoting diuresis to eliminate dampness, strengthening the spleen and stomach, and calming the mind.

[0059] Based on the parts by mass of ginseng, the spleen-strengthening and dampness-resolving composition provided by the present invention includes 1 to 10 parts of stir-fried coix seeds. In the specific embodiments of the present invention, the stir-fried coix seeds in the spleen-strengthening and dampness-resolving composition can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts. In the present invention, stir-fried coix seeds have a sweet and light taste and a slightly cold nature; they belong to the spleen, stomach and lung meridians; and their functions are to promote diuresis to eliminate dampness, remove dampness and relieve pain, strengthen the spleen and stop diarrhea, and clear heat and expel pus.

[0060] In the present invention, the spleen-strengthening and dampness-resolving composition aims at the root causes of obesity, namely qi deficiency and spleen weakness leading to the aggregation of yin pathogens such as phlegm retention and damp turbidity. According to the principles of supplementing qi, strengthening the spleen and resolving dampness, ginseng, astragalus membranaceus, Poria cocos and stir-fried coix seeds are selected to prepare a weight-loss composition as a traditional Chinese medicine preparation or a traditional Chinese medicine tea drink. Among them, astragalus membranaceus is used as the monarch drug, and ginseng, Poria cocos and stir-fried coix seeds are used as the ministerial drugs, jointly achieving the effects of supplementing qi, strengthening the spleen and resolving dampness, and can fundamentally solve the problem of obesity. The spleen-strengthening and dampness-resolving composition provided by the present invention aims at the root causes of obesity and has the advantages of simple formula (only four herbs), simple preparation process (low processing cost), and can be taken for a long time (without side effects), and can play a significant role in the treatment of obesity.

[0061] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention, by mass, can include: 0.5 part of ginseng, 1 part of astragalus membranaceus, 1 part of Poria cocos and 1 part of stir-fried coix seeds.

[0062] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention, by mass, can include: 6 parts of astragalus membranaceus, 10 parts of Poria cocos and 5 parts of stir-fried coix seeds.

[0063] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention, by mass, can include: 10 parts of astragalus membranaceus, 5 parts of Poria cocos and 1 part of stir-fried coix seeds.

[0064] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention, by mass, can include: 5 parts of ginseng, 10 parts of astragalus membranaceus, 1 part of Poria cocos and 1 part of stir-fried coix seeds.

[0065] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention, by mass, can include: 3 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of Poria cocos and 5 parts of stir-fried coix seeds.

[0066] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention may include, by mass: 7 parts of ginseng, 5 parts of astragalus membranaceus, 10 parts of poria cocos, and 10 parts of stir-fried coix seeds.

[0067] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention may include, by mass: 5 parts of ginseng, 1 part of astragalus membranaceus, 5 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0068] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention may include, by mass: 6 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0069] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention may include, by mass: 5 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of poria cocos, and 1 part of stir-fried coix seeds.

[0070] Preferably, the spleen-strengthening and dampness-resolving composition provided by the present invention may include, by mass: 2 parts of ginseng, 10 parts of astragalus membranaceus, 10 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0071] In the present invention, the spleen-strengthening and dampness-resolving composition can be used as a medicine and / or a health product; the spleen-strengthening and dampness-resolving composition can be used as a drink and / or a tea drink; the spleen-strengthening and dampness-resolving composition can be directly soaked in a heat-preserving cup without decocting by mixing the corresponding astragalus membranaceus, poria cocos, stir-fried coix seeds and ginseng traditional Chinese medicine pieces by mass, and used as a tea drink throughout the day; or the corresponding astragalus membranaceus, poria cocos, stir-fried coix seeds and ginseng traditional Chinese medicine pieces can be mixed by mass and then decocted and directly drunk. The present invention has no special limitation on the preparation method of the spleen-strengthening and dampness-resolving composition, and any conventional preparation method in the art can be adopted.

[0072] The present invention also provides a preparation method of the spleen-strengthening and dampness-resolving composition according to the above technical solution, comprising the following steps:

[0073] Soak astragalus membranaceus, poria cocos and stir-fried coix seeds in water, and then conduct the first decoction to obtain the first decoction liquid and the medicinal residues;

[0074] Add water to the medicinal residues for the second decoction to obtain the second decoction liquid;

[0075] If ginseng is not included, mix the first decoction liquid and the second decoction liquid to obtain the spleen-strengthening and dampness-resolving composition;

[0076] If ginseng is included, mix the first decoction liquid, the second decoction liquid and the ginseng decoction liquid to obtain the spleen-strengthening and dampness-resolving composition.

[0077] In the present invention, astragalus membranaceus, poria cocos, and stir-fried coix seeds are soaked in water and then subjected to a first decoction to obtain a first decoction liquid and medicinal residues. In the present invention, it is preferred that astragalus membranaceus, poria cocos, and stir-fried coix seeds are mixed by mass parts and then soaked in water. In the present invention, when astragalus membranaceus, poria cocos, and stir-fried coix seeds are soaked in water, the added amount of water can be 10 to 50 times the mass of astragalus membranaceus, poria cocos, and stir-fried coix seeds. As an optional embodiment of the present invention, the added amount of water can be 10, 15, 20, 25, 30, 35, or 40 times the mass of astragalus membranaceus, poria cocos, and stir-fried coix seeds. The soaking time in the present invention can be 30 to 120 min. As an optional embodiment of the present invention, the soaking time can be 30 min, 40 min, 50 min, 60 min, 70 min, 80 min, 90 min, 100 min, 110 min, or 120 min. The soaking temperature in the present invention can be 10 to 30 °C. As an optional embodiment of the present invention, the soaking temperature can be 10 °C, 15 °C, 20 °C, 25 °C, or 30 °C. The soaking in the present invention can also be directly carried out at room temperature. After soaking is completed, a mixture soaking liquid is obtained in the present invention. After obtaining the mixture soaking liquid, the mixture soaking liquid can be directly subjected to a first decoction in the present invention. It is preferred that the mixture soaking liquid is boiled and then subjected to a first decoction in the present invention. The temperature for the first decoction in the present invention can be 90 to 100 °C, or it can also be 100 °C; the time for the first decoction can be 20 to 40 min, or it can also be 25 to 30 min. After the first decoction is completed, it is preferred that the obtained medicinal liquid is filtered, and the supernatant is taken to obtain the first decoction liquid, and the obtained medicinal residues are added with water for a second decoction. When the medicinal residues are added with water for a second decoction in the present invention, the added amount of water can be 5 to 20 times the mass of the medicinal residues, or it can also be 10 to 15 times. It is preferred that the medicinal residue-water mixture is boiled and then subjected to a second decoction in the present invention. The temperature for the second decoction in the present invention can be 90 to 100 °C, or it can also be 100 °C; the time for the second decoction can be 20 to 40 min, or it can also be 25 to 30 min. After the second decoction is completed, it is preferred to obtain the second decoction liquid by filtration in the present invention. In the present invention, the boiling can be carried out by bringing to a boil over high heat. In the present invention, the decoction can be carried out by simmering to maintain the corresponding temperature.

[0078] In the present invention, when the spleen-strengthening and dampness-resolving composition does not contain ginseng, the first decoction liquid and the second decoction liquid can be directly mixed in the present invention to obtain the spleen-strengthening and dampness-resolving composition. In a specific embodiment of the present invention, after the first decoction liquid and the second decoction liquid are mixed, it is preferably further included to concentrate the decoction liquid; the concentration can be concentrated to 50% of the original volume to obtain the spleen-strengthening and dampness-resolving composition.

[0079] In the present invention, when the spleen-strengthening and dampness-resolving composition contains ginseng, the present invention can mix the first decoction, the second decoction and the ginseng decoction to obtain the spleen-strengthening and dampness-resolving composition. The present invention has no special limitation on the preparation method of the ginseng decoction, and any conventional method in the art can be used. In the specific embodiment of the present invention, the preparation method of the ginseng decoction may include the following steps: soaking ginseng in water and then decocting to obtain the first ginseng decoction and ginseng residues; adding water to the ginseng residues and decocting again to obtain the second ginseng decoction; mixing the first ginseng decoction and the second ginseng decoction to obtain the ginseng decoction. In the present invention, when soaking ginseng in water, the amount of water added may be 10 to 30 times the mass of ginseng, or may be 15 to 20 times; the soaking time of ginseng is 30 to 120 min, or may be 30 min, 40 min, 50 min, 60 min, 70 min, 80 min, 90 min, 100 min, 110 min or 120 min; the temperature during ginseng soaking may be 10 to 30 °C, or may be 10 °C, 15 °C, 20 °C, 25 °C or 30 °C, or may be carried out at room temperature. After the ginseng soaking is completed in the present invention, a ginseng soaking solution is obtained. After obtaining the ginseng soaking solution, the present invention preferably boils the ginseng soaking solution and then decocts it; the decocting temperature may be 90 to 100 °C, or may be 100 °C; the decocting time may be 20 to 40 min, or may be 30 min. After the ginseng decocting is completed, the present invention preferably filters to obtain the first ginseng decoction and ginseng residues. The obtained first ginseng decoction is reserved for use; the ginseng residues are added with water and decocted again; the amount of water added when adding water to the ginseng residues may be 10 to 30 times the mass of the ginseng residues, or may be 15 to 20 times. The present invention preferably boils the ginseng residue water mixture and then decocts it again; the temperature for the second decoction may be 90 to 100 °C, or may be 100 °C; the time for the second decoction may be 20 to 40 min, or may be 30 min. After the second decoction is completed, the present invention preferably filters to obtain the second ginseng decoction. After obtaining the first ginseng decoction and the second ginseng decoction, the present invention preferably mixes the first ginseng decoction and the second ginseng decoction to obtain the ginseng decoction.

[0080] After mixing the first decoction, the second decoction and the ginseng decoction, the present invention can obtain the spleen-strengthening and dampness-resolving composition. In the specific embodiment of the present invention, after mixing the first decoction, the second decoction and the ginseng decoction, it may further include concentration to obtain the spleen-strengthening and dampness-resolving composition; the concentration can be concentrated to 50% of the original volume.

[0081] In the present invention, after obtaining the spleen-strengthening and dampness-resolving composition, it is preferably further included to fill and sterilize the obtained spleen-strengthening and dampness-resolving composition and then store it. The present invention has no special limitation on the sterilization method, and any conventional sterilization method in the art can be used.

[0082] The preparation process of the spleen-strengthening and dampness-resolving composition provided by the present invention is simple and convenient for popularization and utilization.

[0083] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of spleen-strengthening and dampness-resolving products.

[0084] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of products helpful for controlling body fat.

[0085] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of products for weight loss and / or controlling body fat.

[0086] In the present invention, the product may include medicines and / or health products; the medicines include traditional Chinese medicine preparations; the health products include beverages. In the specific embodiment of the present invention, the beverage may include tea drinks.

[0087] The spleen-strengthening and dampness-resolving composition provided by the present invention aims at the root causes of obesity, namely qi deficiency and spleen weakness leading to the aggregation of yin pathogens such as phlegm retention and damp turbidity. According to the principles of supplementing qi, strengthening the spleen, and resolving dampness, ginseng, astragalus membranaceus, poria cocos, and stir-fried coix seeds are selected to prepare a weight loss composition as a traditional Chinese medicine preparation or a traditional Chinese medicine tea drink. Among them, astragalus membranaceus is used as the monarch drug, and ginseng, poria cocos, and stir-fried coix seeds are used as the ministerial drugs, jointly achieving the effects of supplementing qi, strengthening the spleen, and resolving dampness, and fundamentally solving the problem of obesity. Through the clinical application effect, it is found that the spleen-strengthening and dampness-resolving composition can be taken for a long time, and the effects of weight loss and waist thinning can be achieved during the taking period, and it is safe and has no toxic and side effects.

[0088] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of products helpful for maintaining a healthy blood lipid level. In the present invention, the maintaining of a healthy blood lipid level includes maintaining a healthy blood lipid cholesterol level and / or maintaining a healthy blood lipid triglyceride level.

[0089] The present invention provides the application of the spleen-strengthening and dampness-resolving composition described in the above technical solution in the preparation of products for preventing and / or treating hyperlipidemia. In the present invention, the hyperlipidemia may include hypercholesterolemia. The results of the examples of the present invention show that the spleen-strengthening and dampness-resolving composition provided by the present invention can significantly reduce the increase in the contents of total cholesterol, triglyceride, and low-density lipoprotein cholesterol caused by a high-fat diet, and thus can achieve the purpose of preventing and / or treating hyperlipidemia.

[0090] The present invention provides the use of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of a product having an adjuvant effect on liver injury.

[0091] The present invention provides the use of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of a product for preventing and / or treating liver injury. In the present invention, the liver injury includes liver injury caused by a high-fat diet and / or liver injury caused by hyperlipidemia. The results of the examples in the present invention show that the spleen-strengthening and dampness-resolving composition provided by the present invention can significantly reduce the increase in the content of alanine aminotransferase caused by a high-fat diet, achieving prevention, treatment or alleviation of liver injury caused by a high-fat diet.

[0092] The present invention provides the use of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of a product for preventing and / or treating constipation. The present invention provides the use of the spleen-strengthening and dampness-resolving composition described in the above technical solution or the spleen-strengthening and dampness-resolving composition prepared by the preparation method described in the above technical solution in the preparation of a product for moistening the intestines and relieving constipation.

[0093] In the present invention, the product may include medicines and / or health products; the medicines include traditional Chinese medicine preparations; the health products include beverages. In the specific embodiments of the present invention, the beverage may include tea drinks.

[0094] In order to further illustrate the present invention, the technical solutions provided by the present invention will be described in detail below with reference to the drawings and examples, but they should not be construed as limiting the protection scope of the present invention.

[0095] Example 1

[0096] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0097] 0.5 part of ginseng, 1 part of astragalus membranaceus, 1 part of poria cocos and 1 part of stir-fried coix seed.

[0098] The preparation method of the spleen-strengthening and dampness-resolving composition is as follows:

[0099] The traditional Chinese medicine pieces of astragalus membranaceus, poria cocos and stir-fried coix seed are mixed by mass to obtain a first mixture;

[0100] Add water with a mass 10 times that of the first mixture to the first mixture, soak for 30 min, bring to a boil over high heat, then turn to low heat and decoct for 30 min at 90 - 100 °C, filter the medicinal liquid, and take the supernatant to obtain the first decoction. Then add water with a mass 5 times that of the medicinal residues to the obtained medicinal residues, decoct over low heat for 30 min at 90 - 100 °C, and filter to obtain the second decoction;

[0101] Add ginseng slices to water with a mass 10 times that of the ginseng, soak for 30 min, bring to a boil over high heat, then turn to low heat and decoct for 30 min at 90 - 100 °C. Filter the decoction liquid and take the supernatant to obtain the first ginseng decoction liquid. Add water with a mass 10 times that of the residue to the obtained ginseng residue, decoct over low heat for 30 min at 90 - 100 °C, and filter to obtain the second ginseng decoction liquid. Mix the first ginseng decoction liquid and the second ginseng decoction liquid to obtain the ginseng decoction liquid;

[0102] Mix the first decoction liquid, the second decoction liquid and the ginseng decoction liquid, and concentrate to 50% of the original volume to obtain the spleen - strengthening and dampness - resolving composition. Fill and sterilize the obtained spleen - strengthening and dampness - resolving composition for storage. The concentrated liquid prepared by the above method can also be called the spleen - strengthening and dampness - resolving extract.

[0103] Example 2

[0104] A spleen - strengthening and dampness - resolving composition, by mass, consists of:

[0105] 6 parts of astragalus membranaceus, 10 parts of poria cocos and 5 parts of stir - fried coix seeds.

[0106] The preparation method of the spleen - strengthening and dampness - resolving composition is as follows:

[0107] Mix the traditional Chinese medicine slices of astragalus membranaceus, poria cocos and stir - fried coix seeds according to the mass parts to obtain the first mixture;

[0108] Add water with a mass 10 times that of the first mixture to the first mixture, soak for 30 min, bring to a boil over high heat, then turn to low heat and decoct for 30 min at 90 - 100 °C. Filter the decoction liquid and take the supernatant to obtain the first decoction liquid. Add water with a mass 5 times that of the residue to the obtained residue, decoct over low heat for 30 min at 90 - 100 °C, and filter to obtain the second decoction liquid;

[0109] Mix the first decoction liquid and the second decoction liquid, and concentrate to 50% of the original volume to obtain the spleen - strengthening and dampness - resolving composition. Fill and sterilize the obtained spleen - strengthening and dampness - resolving composition for storage. The concentrated liquid prepared by the above method can also be called the spleen - strengthening and dampness - resolving extract.

[0110] Example 3

[0111] A spleen - strengthening and dampness - resolving composition, by mass, consists of:

[0112] 10 parts of astragalus membranaceus, 5 parts of poria cocos and 1 part of stir - fried coix seeds.

[0113] The preparation method of the spleen - strengthening and dampness - resolving composition is the same as that in Example 2. The obtained concentrated liquid can be called the spleen - strengthening and dampness - resolving extract.

[0114] Example 4

[0115] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0116] 5 parts of ginseng, 10 parts of astragalus membranaceus, 1 part of poria cocos, and 1 part of stir-fried coix seeds.

[0117] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that of Example 1. The obtained concentrated liquid can be called the spleen-strengthening and dampness-resolving extract.

[0118] Example 5

[0119] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0120] 3 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0121] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that of Example 1. The obtained concentrated liquid can be called the spleen-strengthening and dampness-resolving extract.

[0122] Example 6

[0123] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0124] 7 parts of ginseng, 5 parts of astragalus membranaceus, 10 parts of poria cocos, and 10 parts of stir-fried coix seeds.

[0125] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that of Example 1. The obtained concentrated liquid can be called the spleen-strengthening and dampness-resolving extract.

[0126] Example 7

[0127] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0128] 5 parts of ginseng, 1 part of astragalus membranaceus, 5 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0129] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that of Example 1. The obtained concentrated liquid can be called the spleen-strengthening and dampness-resolving extract.

[0130] Example 8

[0131] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0132] 6 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0133] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that of Example 1. The obtained concentrated liquid can be called the spleen-strengthening and dampness-resolving extract.

[0134] Example 9

[0135] A spleen-strengthening and dampness-resolving composition, by mass, consists of:

[0136] 5 parts of ginseng, 5 parts of astragalus membranaceus, 5 parts of poria cocos, and 1 part of stir-fried coix seeds.

[0137] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that in Example 1. The obtained concentrated liquid can be called spleen-strengthening and dampness-resolving extract.

[0138] Example 10

[0139] A spleen-strengthening and dampness-resolving composition, by mass, is composed of:

[0140] 2 parts of ginseng, 10 parts of astragalus membranaceus, 10 parts of poria cocos, and 5 parts of stir-fried coix seeds.

[0141] The preparation method of the spleen-strengthening and dampness-resolving composition is the same as that in Example 1. The obtained concentrated liquid can be called spleen-strengthening and dampness-resolving extract.

[0142] Example 11

[0143] A spleen-strengthening and dampness-resolving composition, with the same composition as in Example 1, the only difference being: it does not contain ginseng. The preparation method is the same as that in Example 1. The obtained concentrated liquid can be called spleen-strengthening and dampness-resolving extract.

[0144] Comparative Example 1

[0145] A composition, with the same composition as in Example 1, the only difference being: it does not contain astragalus membranaceus. The preparation method is the same as that in Example 1.

[0146] Comparative Example 2

[0147] A composition, with the same composition as in Example 1, the only difference being: it does not contain poria cocos. The preparation method is the same as that in Example 1.

[0148] Comparative Example 3

[0149] A composition, with the same composition as in Example 1, the only difference being: it does not contain stir-fried coix seeds. The preparation method is the same as that in Example 1.

[0150] Application Example 1

[0151] The application effect of the spleen-strengthening and dampness-resolving composition prepared in Example 1 was verified as follows:

[0152] 1. Zhang Moumin, male, 55 years old, 178 cm in height, 92 kg in weight, 103.3 cm in waist circumference. Oral administration of 200 ml of the spleen-strengthening and dampness-resolving composition in Example 1 every day for 8 months, with unchanged eating habits and exercise volume. The weight reached 83 kg, with a weight loss of 9 kg, and the waist circumference reached 93.3 cm, with a reduction of 10 cm. The effect of reducing fat and slimming the waist was obvious.

[0153] 2. Zhu Mouyang, male, 61 years old, 75 kg in weight, 93.3 cm in waist circumference. Oral administration of 200 ml of the spleen-strengthening and dampness-resolving weight-loss tea drink in Example 1 every day for 110 days, with unchanged eating habits and exercise volume. The weight decreased to 66 kg, with a weight loss of 9 kg, and the waist circumference was 86.3 cm, with a reduction of 7 cm.

[0154] 3. Zhang Moying, female, 56 years old, 163 cm in height, 62.2 kg in weight, 78 cm in waist circumference. She took 200 ml of the spleen - strengthening and dampness - resolving composition of Example 1 orally every day. With her eating habits and exercise amount unchanged, after 21 days, her weight dropped to 59.45 kg, a loss of 2.75 kg, and her waist circumference decreased to 72 cm, a reduction of 6 cm. The effect of reducing fat and slimming the waist is obvious.

[0155] 4. Chen Mimin, male, 56 years old, 171 cm in height, 81 kg in weight, 90 cm in waist circumference. He took 200 ml of the spleen - strengthening and dampness - resolving composition of Example 1 orally every day. After 3 months, his weight was 77 kg and his waist circumference was 86.6 cm. His weight decreased by 4 kg and his waist circumference decreased by 3.4 cm.

[0156] 5. A 24 - year - old female, 167 cm in height, 70 kg in weight. She usually had constipation and needed to take medicine to defecate smoothly. She took the spleen - strengthening and dampness - resolving weight - loss tea of Example 1 orally for 3 days. Her weight did not decrease, but her constipation improved. Constipation occurred again 2 - 3 days after stopping taking the medicine. This girl used to burp easily after meals, but this rarely happened after taking this medicine.

[0157] Application Example 2

[0158] Animal experiments to verify the weight - loss and fat - reducing effects of the spleen - strengthening and dampness - resolving composition.

[0159] 1. Experimental animals: SPF - level SD rats, 6 - 8 weeks old, 42 males, 6 in each group, with a body weight of 180 ± 20 g.

[0160] 2. Basal diet and high - lipid diet were purchased from Beijing Keao Xieli Co., Ltd. The feed ingredients and formulations are shown in Tables 1 and 2.

[0161] Table 1 Ingredients and formulation of basal diet

[0162]

[0163] Table 2 Ingredients and formulation of high - lipid diet

[0164]

[0165] 3.1 Grouping and treatment of experimental animals

[0166] Divided into 7 groups: The normal group (NC) was fed with basal diet, the model group (MODEL) and other experimental groups were fed with high - lipid diet. Experimental group C0 was the group of this prescription, experimental group C1 was the group without ginseng, experimental group C2 was the group without astragalus membranaceus, experimental group C3 was the group without poria cocos, and experimental group C4 was the group without stir - fried coix seed.

[0167] The rats were weighed and randomly divided into seven groups. Among them, the NC group was fed with a basal diet and given normal drinking water; the model group was fed with a high-lipid diet and given normal drinking water; the C0 group was fed with a high-lipid diet and given normal drinking water, and the spleen-strengthening and dampness-resolving composition prepared in Example 1 was added to the water; the C1 group was fed with a high-lipid diet and given normal drinking water, and the spleen-strengthening and dampness-resolving composition prepared in Example 11 was added to the water; the C2 group was fed with a high-lipid diet and given normal drinking water, and the composition prepared in Comparative Example 1 was added to the water; the C3 group was fed with a high-lipid diet and given normal drinking water, and the composition prepared in Comparative Example 2 was added to the water; the C4 group was fed with a high-lipid diet and given normal drinking water, and the composition prepared in Comparative Example 3 was added to the water. Each experimental group was continuously fed for 28 days.

[0168] 3.2 Detection indexes

[0169] (1) Feed consumption, and the feed consumption of rats in each group was detected every day.

[0170] (2) Changes in rat body weight

[0171] The rats were weighed once a week, and the data were recorded. They were fasted for 12 h before weighing.

[0172] (3) Changes in rat body length and body width

[0173] They were measured once a week, and the data were recorded. They were fasted for 12 h before measurement.

[0174] (4) Detection of rat obesity index

[0175] According to the literature calculation formula as follows:

[0176] Rohrer index = [{body weight (g) / body length (cm) 3} x 10]

[0177] Lee index = [{body weight (g) 1 / 3 / body length (cm)} x 10 3

[0178] T.M.Index = [{body weight (g) / body length (cm) 2.823} x 10 3

[0179] (5) Detection of the fat content (BodyFatMass) in rats

[0180] BodyFatMass = [0.581 × T.M.index - 22.03]

[0181] (6) Serum chemical analysis of rats

[0182] On the 28th day after feeding the SD rats, blood was collected by eye enucleation, the serum was separated, and analyzed using a serum chemical analyzer.

[0183] Analyze 5 indicators: TC - total cholesterol, TG - triglyceride, LDL-C - low-density lipoprotein cholesterol, HDL-C - high-density lipoprotein cholesterol, and ALT - alanine aminotransferase.

[0184] (7) Data processing

[0185] Processed using SPSS 21.0 statistical analysis software, the data is expressed as mean ± standard deviation (SD), and one-way ANOVA is used for inter-group comparison. A significant difference is considered when P < 0.05.

[0186] 4. Experimental results

[0187] During the experiment, the animals in each group were active normally, had good diets, and no abnormal feces were observed.

[0188] 4.1 Feed consumption of rats

[0189] The total feed consumption of rats in each experimental group is as Figure 1 shown. Figure 1 The data in it is the total actual feed consumption of each mouse in each experimental group.

[0190] From Figure 1 it can be obtained that the total actual feed consumption of mice in each experimental group is relatively consistent as a whole, and there is no significant difference in the total actual feed consumption among the experimental groups.

[0191] 4.2 Body weight changes of rats

[0192] The weekly body weight growth rate of each rat in each experimental group is as Figure 2 shown; the cumulative body weight growth rate of each rat in each experimental group is as Figure 3 shown. Among them Figure 2 and Figure 3 the vertical axis of is the growth rate.

[0193] Table 3 Body weights of each experimental group (mean, unit: g)

[0194] Group Before the experiment The first week The second week The third week The fourth week NC 199.68±11.17 253.53±7.22 291.78±11.12 303.55±13.56 354.15±11.06 MODEL 199.17±9.70 253.83±10.67 291.05±12.92 304.42±12.92 342.02±10.11 C0 199.13±9.35 259.90±11.96 290.45±8.68 304.65±9.42 323.52±8.13 C1 199.40±10.61 247.03±12.83 277.03±11.05 293.18±8.69 332.12±8.29 C2 199.67±8.07 244.28±19.09 279.53±17.85 298.58±17.99 343.03±21.63 C3 199.77±11.85 254.25±15.11 291.67±15.17 317.85±11.31 360.53±15.80 C4 199.42±10.29 244.88±8.70 276.95±17.42 299.58±20.36 342.57±27.57

[0195] From Figures 2 - 3 it can be analyzed that by the fourth week, the body weight of the MODEL group increased less than that of the NC group. It is speculated that the high oil content in the high-fat diet may affect the appetite of rats. Among all the groups fed with high-lipid diets, the body weight growth rate of the C0 group is the lowest, indicating that this formula is the best. Removing any one of its components will result in a poorer or even no weight loss effect.

[0196] 4.3 Body length changes of rats

[0197] The body lengths of each rat in each experimental group per week are shown in Table 4. The changes in the body lengths of each rat in each experimental group per week are shown in Table 4 and Figure 4 as follows.

[0198] Table 4 Body lengths of each experimental group (mean, unit: cm)

[0199] Before the experiment The first week The second week The third week The fourth week NC 20.03±0.73 21.57±0.37 22.15±0.53 22.30±0.49 23.55±0.60 MODEL 20.08±0.62 21.37±0.38 22.37±0.50 22.38±0.93 23.22±0.71 C0 20.18±0.51 21.23±0.56 22.37±0.63 22.42±0.78 23.10±0.70 C1 20.27±0.62 21.10±0.37 21.98±0.50 22.32±0.39 22.80±0.74 C2 20.25±0.64 20.93±0.68 21.75±0.52 22.23±0.39 22.48±0.69 C3 20.48±0.88 20.90±0.58 21.68±0.66 21.77±0.55 22.43±0.55 C4 20.25±0.36 20.97±0.58 22.17±0.97 22.28±0.73 23.13±1.01

[0200] From Table 4 and Figure 4 it can be seen that there is no significant difference in the body length growth among groups by the fourth week.

[0201] 4.4 Changes in rat body width

[0202] The body widths of each rat in each experimental group per week are shown in Table 5. The changes in the body widths of each rat in each experimental group per week are shown in Table 5 and Figure 5 as follows.

[0203] Table 5 Body widths of each experimental group (mean, unit: cm)

[0204] Group Before the experiment The first week The second week The third week The fourth week NC 12.98±0.87 15.47±0.31 15.80±0.52 16.13±0.48 17.34±0.42 MODEL 13.88±0.61 15.80±0.81 16.66±0.23 16.86±0.62 17.13±0.41 C0 13.51±0.49 15.54±0.68 16.55±0.69 15.97±0.59 15.63±0.41 C1 13.62±0.56 15.26±0.51 16.16±0.61 15.84±0.33 16.48±0.56 C2 14.04±0.52 15.26±0.30 15.79±0.62 15.93±0.58 16.37±0.67 C3 14.73±0.60 15.79±0.47 15.98±0.65 16.55±0.29 16.76±0.43 C4 14.46±0.89 15.98±0.40 15.66±0.55 16.15±0.55 16.42±0.77

[0205] From Table 5 and Figure 5 it can be seen that the body width of rats in group C0 shows a trend of increasing first and then gradually decreasing.

[0206] 4.5 Detection of rat obesity index

[0207] The detection results of the obesity index of rats in each experimental group are shown in Table 6.

[0208] Table 6 Detection results of the obesity index of rats in each experimental group

[0209] Group Rohrer index Lee index T.M. Index NC 0.2796±0.0167 303.42±5.90 48.88±2.80 MODEL 0.2846±0.0314 304.98±11.22 49.53±5.17 C0 0.2630±0.0181 297.27±6.85 45.84±2.94 C1 0.2815±0.0255 303.96±9.23 48.93±4.17 C2 0.3023±0.0214 311.37±7.18 52.43±3.49 C3 0.3224±0.0346 317.91±11.47 55.87±5.77 C4 0.2775±0.0247 302.55±8.97 48.37±4.01

[0210] From Table 6, it can be seen that the Rohrer index, Rohrerindex, and T.M.Index of rats in the MODEL group are all increased compared with those in the NC group, while groups C0, C1, and C4 can reduce the Rohrer index, Rohrerindex, and T.M.Index to varying degrees. Among them, group C0 is more prominent in reducing the Rohrer index, Rohrer index, and T.M.Index. The Rohrerindex, Rohrerindex, and T.M.Index of groups C2 and C3 not only do not decrease compared with the MODEL group, but instead increase. From the above, it can be seen that the spleen-strengthening and dampness-resolving composition in Example 1 is more prominent in terms of weight loss.

[0211] 4.6 Detection of rat body fat content (Body Fat Mass)

[0212] The detection results of the fat content in the rats of each experimental group are shown in Table 7.

[0213] Table 7 Detection results of the fat content in the rats of each experimental group

[0214] Group Body fat content NC 6.37±1.63 MODEL 6.75±3.01 C0 4.60±1.71* C1 6.40±2.42 C2 8.43±2.03 C3 10.43±3.35* C4 6.07±2.33

[0215] It can be seen from Table 7 that, compared with the NC group, the fat content in the MODEL group increased. C0, C1, and C4 reduced the body fat to varying degrees, and the C0 group had the lowest body fat content. It shows that the spleen-strengthening and dampness-resolving composition of Example 1 has a more significant advantage in reducing the body fat content.

[0216] 4.7 Analysis of serum biochemical indexes of rats

[0217] The detection results of the serum indexes of the rats in each experimental group are shown in Table 8 and Figures 6 - 10 as follows. Among them Figure 6 is the detection result of the serum TC index of each experimental group; Figure 7 is the detection result of the serum TG index of each experimental group; Figure 8 is the detection result of the serum LDL-C index of each experimental group; Figure 9 is the detection result of the serum HDL-C index of each experimental group; Figure 10 is the detection result of the serum ALT index of each experimental group. In the figure, * indicates a significant difference, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns indicates no significant difference, p > 0.05.

[0218] Table 8 Detection results of the serum indexes of the rats in each experimental group

[0219] Group TC TG LDL-C HDL-C ALT NC 2.25±0.18 0.49±0.19 0.38±0.03 1.10±0.16 92.05±17.13 Model 3.91±0.45 3.25±0.29 0.90±0.10 0.62±0.07 183.65±18.91 C0 2.23±0.11 1.10±0.19 0.66±0.07 0.79±0.06 83.63±17.81

[0220] From Table 8 and Figures 6 - 10It can be seen that the serum biochemical indexes of the high-fat diet model group, the C0 test group and the normal control group were analyzed. It was found that the TC, TG, LDL-C and ALT in the high-fat diet model group were all extremely significantly higher than those in the normal control group, while the HDL-C was extremely significantly lower than that in the normal control group. TC refers to the sum of all types of cholesterol in the blood, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG); TG is triglyceride, a lipid in the blood and the main form of energy storage in the body. High triglyceride levels may be associated with an increased risk of cardiovascular disease; LDL-C is low-density lipoprotein cholesterol, usually referred to as "bad cholesterol" because it forms plaques on the arterial wall, which may lead to atherosclerosis and cardiovascular disease; ALT is alanine aminotransferase, a liver enzyme usually used to evaluate liver health. An elevated ALT level may indicate liver damage or inflammation. HDL-C is high-density lipoprotein cholesterol, usually referred to as "good cholesterol" because it helps remove LDL-C from the blood, thus reducing the risk of cardiovascular disease. The increase in these indexes of TC, TG, LDL-C and ALT and the decrease in HDL-C indicate that the high-fat diet is not conducive to the health of rats.

[0221] As can be seen from Table 8 and Figures 6 - 10 It can be seen that the TC, TG, LDL-C and ALT in the C0 test group were all extremely significantly lower than those in the high-fat model group. Among them, TC and ALT had no difference from the normal control group, indicating that taking the spleen-strengthening and dampness-resolving composition of the present invention is helpful for the health of rats, causes no damage to the liver, and helps relieve liver damage caused by a high-fat diet.

[0222] In summary: The rats in the C0 group had the lightest body weight, were tall and thin in body shape compared with the rats in the model group and other drug groups. From the second week, the body width showed a downward trend, and the obesity index was the lowest. The spleen-strengthening and dampness-resolving composition provided by the present invention can significantly reduce the contents of TC, TG, LDL-C and ALT in the serum of high-fat rats, which is beneficial to the health of rats.

[0223] Although the above embodiments have described the present invention in detail, they are only a part of the embodiments of the present invention, not all of them. People can also obtain other embodiments according to these embodiments without creative efforts, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A spleen-strengthening and dampness-resolving composition, characterized in that, By mass parts, it includes: 0 - 10 parts of ginseng, 1 - 10 parts of astragalus membranaceus, 1 - 10 parts of poria cocos, and 1 - 10 parts of stir-fried coix seed.

2. The spleen-strengthening and dampness-resolving composition according to claim 1, wherein By mass parts, it includes: 0 - 5 parts of ginseng, 5 - 10 parts of astragalus membranaceus, 1 - 5 parts of poria cocos, and 1 - 5 parts of stir-fried coix seed; or, 5 - 7 parts of ginseng, 1 - 5 parts of astragalus membranaceus, 5 - 10 parts of poria cocos, and 5 - 10 parts of stir-fried coix seed; or, 6 - 10 parts of astragalus membranaceus, 5 - 10 parts of poria cocos, and 1 - 5 parts of stir-fried coix seed. or, 0 - 5 parts of ginseng, 5 - 10 parts of astragalus membranaceus, 5 - 10 parts of poria cocos, and 1 - 5 parts of stir-fried coix seed.

3. The spleen-strengthening and dampness-resolving composition according to claim 1, wherein By mass parts, it includes: 0.5 part of ginseng, 1 part of astragalus membranaceus, 1 part of poria cocos, and 1 part of stir-fried coix seed.

4. The preparation method of the spleen-invigorating and dampness-resolving composition according to any one of claims 1 to 3, characterized in that, It includes the following steps: Soak astragalus membranaceus, poria cocos, and stir-fried coix seed in water, and then conduct the first decoction to obtain the first decoction liquid and medicinal residues; Add water to the medicinal residues for the second decoction to obtain the second decoction liquid; When ginseng is not included, mix the first decoction liquid and the second decoction liquid to obtain the spleen-strengthening and dampness-resolving composition; When ginseng is included, mix the first decoction liquid, the second decoction liquid, and the ginseng decoction liquid to obtain the spleen-strengthening and dampness-resolving composition.

5. The preparation method according to claim 4, wherein When soaking astragalus membranaceus, poria cocos, and stir-fried coix seed in water, the addition amount of water is 10 - 50 times the mass of astragalus membranaceus, poria cocos, and stir-fried coix seed; the soaking time is 30 - 120 min; the temperature for each decoction is 90 - 100 °C; the time for each decoction is 20 - 40 min.

6. The preparation method according to claim 4, characterized in that, The preparation method of the ginseng decoction liquid includes the following steps: Soak ginseng in water and then conduct decoction to obtain the first ginseng decoction liquid and ginseng residues; Add water to the ginseng residues for re-decoction to obtain the second ginseng decoction liquid; Mix the first ginseng decoction liquid and the second ginseng decoction liquid to obtain the ginseng decoction liquid.

7. The preparation method according to claim 6, wherein When soaking ginseng in water, the addition amount of water is 10 - 30 times the mass of ginseng; the soaking time of ginseng is 30 - 120 min; when decocting ginseng, the temperature for each decoction is 90 - 100 °C; the time for each decoction is 20 - 40 min.

8. Use of the spleen-strengthening and dampness-resolving composition according to any one of claims 1 - 3 or the spleen-strengthening and dampness-resolving composition prepared by the preparation method according to any one of claims 4 - 7 in the preparation of the following products (1) - (9): (1) Spleen-strengthening and dampness-resolving products; (2) Products helpful for controlling body fat; (3) Products for weight loss and / or controlling body fat; (4) Products helpful for maintaining a healthy blood lipid level; (5) Products for preventing and / or treating hyperlipidemia; (6) Products having an adjuvant effect on liver injury; (7) Products for preventing and / or treating liver injury; (8) Products for preventing and / or treating constipation; (9) Products for moistening the intestines and relieving constipation.

9. The application according to claim 8, wherein The products include drugs and / or health products; the products include beverages and / or tea drinks.

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