Traditional Chinese medicine composition for protecting liver and dispelling effects of alcohol as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for protecting the liver and dispelling the effects of alcohol as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine, the traditional Chinese medicine composition for protecting the liver and dispelling the effects of alcohol is prepared from the following raw materials in parts by weight: 15-25 parts of lucid ganoderma, 15-25 parts of sea-buckthorn, 15-25 parts of hovenia dulcis thunb, 15-25 parts of radix puerariae and 5-15 parts of malt. According to the formula, the ganoderma lucidum and the sea-buckthorn are used as monarch drugs, the hovenia dulcis thunb is used as a ministerial drug, the radix puerariae is used as an adjuvant drug, and the malt is used as a conductant drug, so that the traditional Chinese medicine composition has various excellent effects of dispelling effects of alcohol, protecting liver, protecting heart, relieving cardiac pressure, protecting stomach, arresting vomiting, dispelling dizziness and headache, accelerating alcohol metabolism, dispelling effects of alcohol, soothing nerves, rapidly relieving discomfort caused by drinking, dispelling hangover and the like.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for protecting the liver and relieving hangover, its preparation method and application. Background Art

[0002] Excessive drinking is likely to cause liver damage and corresponding liver diseases, and can also trigger other diseases. In severe cases, it can cause disorders of human physiological functions and even death. Alcoholic liver damage caused by excessive drinking has become one of the main factors for liver disease patients. At the same time, excessive alcoholism often leads to malignant diseases such as hypertension and gastric cancer, and metabolic disorders of substances such as proteins. The most common poison causing liver damage is alcohol, and liver damage caused by excessive drinking has become a worldwide medical problem. Therefore, the need to sober up, relieve hangover and reduce the harm of drinking to organs such as the gastrointestinal tract and liver of the human body is extremely urgent, and developing effective hangover drugs is of great significance.

[0003] Among the current hangover products on the market, they are mainly chemical drugs and traditional Chinese medicine preparations. Among them, chemical drugs are difficult to play a role in protecting the liver, have large toxic and side effects, and traditional Chinese medicine preparations with homology of medicine and food have certain advantages. Patent CN111184807A discloses a traditional Chinese medicine composition with hangover and liver protection and liver care activities. The medicinal ingredients come from Ampelopsis grossedentata, Momordica grosvenori, Lilium brownii, Prunus mume, Morus alba, Puerariae flos, Glycyrrhiza uralensis, etc. This traditional Chinese medicine composition is prepared from plants with homology of medicine and food and has a certain effect on improving various discomfort symptoms after drinking, but the hangover effect still needs to be further improved. Summary of the Invention

[0004] The purpose of the present invention is to solve the above problems and provide a traditional Chinese medicine composition for protecting the liver and relieving hangover, its preparation method and application. The traditional Chinese medicine composition for protecting the liver and relieving hangover has a good hangover effect and reduces the damage of alcohol to the body.

[0005] The purpose of the present invention is achieved through the following technical solutions:

[0006] A traditional Chinese medicine composition for protecting the liver and relieving hangover, the main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 15-25 parts of Ganoderma lucidum, 15-25 parts of Hippohgae rhamnoides L., 15-25 parts of Hovenia acerba Lindl., 15-25 parts of Pueraria lobata (Willd.) Ohwi, 5-15 parts of malt.

[0007] Preferably, the main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 18-21 parts of Ganoderma lucidum, 18-21 parts of Hippohgae rhamnoides L., 18-21 parts of Hovenia acerba Lindl., 15-21 parts of Pueraria lobata (Willd.) Ohwi, 9-13 parts of malt. Most preferably, the main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 20 parts of Ganoderma lucidum, 19 parts of Hippohgae rhamnoides L., 19 parts of Hovenia acerba Lindl., 17 parts of Pueraria lobata (Willd.) Ohwi, 12 parts of malt.

[0008] Preferably, the liver-protecting and hangover-relieving composition further comprises excipients selected from one or more mixtures of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey.

[0009] More preferably, the excipients consist of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey. By weight, there are 1 - 3 parts of hawthorn, 0.5 - 1.5 parts of longan pulp, 0.5 - 1.5 parts of American ginseng, 0.1 - 1 part of Dendrobium officinale, 0.1 - 1 part of saffron, and 0.5 - 1.5 parts of honey.

[0010] Most preferably, the excipients consist of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey. By weight, there are 2 parts of hawthorn, 1 part of longan pulp, 1 part of American ginseng, 0.5 part of Dendrobium officinale, 0.5 part of saffron, and 1 part of honey.

[0011] The above-mentioned traditional Chinese medicine raw materials of the present invention are obtained according to the standards of the Pharmacopoeia of the People's Republic of China.

[0012] Latin name of Ganoderma lucidum: Ganoderma lucidum(Leyss.ex Fr.)Karst.

[0013] Latin name of Hippophae rhamnoides: Hippophae rhamnoides L.

[0014] Latin name of Hovenia dulcis: Hovenia dulcis Thunb.

[0015] Latin name of Pueraria lobata: Pueraria lobata(Willd.)Ohwi

[0016] Latin name of Hordeum vulgare: Hordeum vulgare L.

[0017] Latin name of Crataegus pinnatifida: Crataegus pinnatifida Bunge

[0018] Latin name of Dimocarpus longan: Dimocarpus longan Lour.

[0019] Latin name of Panax quinquefolius: Panax quinquefolius L.

[0020] Latin name of Dendrobium officinale: Dendrobium officinale Kimura et Migo

[0021] Latin name of Crocus sativus: Crocus sativus L.

[0022] The present invention also provides a method for preparing a Chinese medicine composition for protecting liver and relieving alcohol, that is, obtaining a Chinese medicine extract, and extracting effective ingredients from the above-mentioned Chinese medicine composition as a raw material. In the present invention, the raw material components and their formulas in the Chinese medicine composition are the most critical. After knowing the Chinese medicine formula, those skilled in the art can directly grind or crush each medicine according to the ratio and mix them as effective ingredients. In addition, those skilled in the art can also use various conventional Chinese medicine effective ingredient extraction methods to extract its effective ingredients, such as conventional decoction, water extraction and alcohol precipitation method, alcohol extraction and water precipitation method, salting out method, etc., because the above-mentioned extraction methods can obtain the main effective ingredients in the above-mentioned Chinese medicine formula.

[0023] After the effective ingredients are extracted from the Chinese medicine composition, the Chinese medicine extract can be concentrated, purified or dried through conventional steps. The concentration method includes but is not limited to: atmospheric pressure evaporation, reduced pressure evaporation, thin film evaporation, and multiple effect evaporation; the purification method includes but is not limited to: salting out purification, macroporous resin adsorption purification, ethanol precipitation purification, ion exchange resin purification, flocculation precipitation purification, membrane separation purification, polyamide adsorption purification, silica gel adsorption chromatography purification, etc.; the drying method includes but is not limited to: drying method, drum drying method, belt drying method, moisture absorption drying method, boiling drying method, spray drying method, reduced pressure drying method, freeze drying method, infrared drying method, microwave drying method, etc.

[0024] In a preferred embodiment, the preparation method of the above-mentioned liver-protecting and alcohol-relieving Chinese medicine composition comprises the following steps:

[0025] (1) Grind ganoderma lucidum, seabuckthorn, Hovenia dulcis, kudzu root, malt, hawthorn, longan pulp, American ginseng, dendrobium officinale, and saffron, and pass through a 60-100 mesh sieve to obtain fine powder for later use;

[0026] (2) extracting the obtained fine powder with 8-15 times deionized water for 2-3 times, each time for 1-3 hours, filtering, concentrating the filtrate, drying, and crushing to obtain a Chinese medicine extract;

[0027] (3) Mix the Chinese herbal medicine extract with honey to prepare a preparation.

[0028] The Chinese medicine composition is used in the preparation of a liver-protecting and alcohol-relieving drug. The dosage form of the Chinese medicine composition includes hard capsules, soft capsules, tablets, granules, powders, pills or oral liquids.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] Based on the traditional Chinese medicine mechanism of "sovereign, minister, assistant, and guide", the prescription of Ganoderma lucidum, Hippohgae rhamnoides, Hovenia dulcis, Pueraria lobata, and malt provided by the present invention has a synergistic effect, with the liver-protecting and hangover-relieving composition having small side effects and good hangover effects. Among them, Ganoderma lucidum serves as the sovereign drug, mainly utilizing its properties of protecting liver cells from damage, promoting liver cell regeneration, improving blood circulation, and reducing blood viscosity in this prescription to assist in the exertion of the overall medicinal effect. Hippohgae rhamnoides also serves as the sovereign drug, mainly using its functions of warming the spleen qi, quickly repairing the gastrointestinal mucosa, enhancing the ability of the spleen and stomach to withstand, promoting lung qi dispersing and liver protecting while improving blood circulation, and working together with Ganoderma lucidum to strengthen the main efficacy of the prescription. Hovenia dulcis serves as the minister drug, mainly exerting its effects of relieving alcohol toxicity, promoting diuresis and detumescence, and soothing the liver and relieving depression in this prescription. It can help improve the discomfort symptoms caused by excessive drinking, such as nausea, vomiting, dizziness, etc., and at the same time reduce the burden on the liver. Pueraria lobata serves as the assistant drug, which has the effects of relieving muscle soreness and fever, promoting eruption, promoting fluid production to quench thirst, and lifting yang to stop diarrhea. At the same time, it can soothe the liver and relieve depression, and is used to treat the discomfort symptoms caused by liver qi stagnation, such as chest and rib distending pain, chest tightness, abdominal distension, etc., and works together with Hovenia dulcis to strengthen the protection and conditioning of the liver. Malt serves as the guide drug, mainly playing the role of harmonizing various drugs and promoting the exertion of the medicinal effect. At the same time, it itself also has the effect of promoting digestion and strengthening the stomach, which helps to improve the function of the digestive system.

[0031] In summary, this prescription takes Ganoderma lucidum and Hippohgae rhamnoides as the sovereign drugs, emphasizing liver protection, protecting the gastrointestinal mucosa, and promoting blood circulation; takes Hovenia dulcis as the minister drug, focusing on relieving alcohol toxicity, promoting diuresis and detumescence, and soothing the liver and relieving depression; takes Pueraria lobata as the assistant drug, assisting in soothing the liver and relieving depression and strengthening liver protection; takes malt as the guide drug, harmonizing various drugs and promoting the exertion of the medicinal effect. Overall, this prescription aims to regulate liver function, protect the liver from damage, improve the gastrointestinal internal environment, protect the gastrointestinal mucosa, relieve alcohol toxicity, improve the function of the digestive system, and enhance the body's immunity.

[0032] The liver-protecting and hangover-relieving traditional Chinese medicine composition provided by the present invention has multiple effects such as relieving alcohol and protecting the liver, protecting the heart, relieving heart pressure, protecting the stomach and stopping vomiting, ascending the clear and descending the turbid, dispelling dizziness and headache, accelerating alcohol metabolism, waking up the drinker and calming the nerves, quickly relieving the discomfort caused by drinking, and dispelling hangover. It can accelerate alcohol metabolism, relieve alcohol and protect the liver, quickly relieve alcohol, and accelerate alcohol decomposition. Drinkers did not show excessive heart rate or rapid and forceful pulse. The present invention can effectively protect the gastrointestinal tract of drinkers, reduce gastric discomfort, diarrhea, etc. When drinkers experience gastric discomfort, taking the oral preparation of the present invention can quickly regulate gastric discomfort. The present invention especially has the effects of dispelling hangover and quickly waking up from a hangover, enabling alcohol to be quickly metabolized, protecting the heart and gastrointestinal tract, being able to quickly wake up from a hangover and calm the nerves, having good sleep, and having no discomfort or hangover when waking up the next day. Description of the Drawings

[0033] Figure 1 Effect of sample E1 in Example on the survival rate of drunken mice in each group. Detailed Embodiments

[0034] Before further describing the specific embodiments of the present invention, it should be understood that the protection scope of the present invention is not limited to the following specific embodiments; it should also be understood that the terms used in the embodiments of the present invention are for describing specific embodiments and not for limiting the protection scope of the present invention. For the test methods without specific conditions noted in the following examples, they are generally carried out under conventional conditions or according to the conditions recommended by each manufacturer.

[0035] When the embodiments give a numerical range, it should be understood that unless otherwise specified in the present invention, both endpoints of each numerical range and any value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as commonly understood by those skilled in the art of this technology. In addition to the specific methods, equipment, and materials used in the embodiments, according to the knowledge of those skilled in the art of this technology and the description of the present invention, any methods, equipment, and materials similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to implement the present invention.

[0036] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt the conventional techniques in this technical field.

[0037] The raw materials (or medicinal materials) used in the present invention can all be purchased from ordinary pharmacies or Chinese medicinal materials sales companies, and their specifications meet the national medical standards or relevant regulations such as the Chinese Pharmacopoeia.

[0038] The curative effect standard of the present invention refers to the relevant curative effect standard in the "Curative Effect Judgment Standard for Chinese Medical Conditions".

[0039] In principle, the preparation process of the present invention applies the "Technical Requirements for the Research of the Preparation Process of New Chinese Medicines", extracts the main active ingredients of the medicine by using modern preparation new technologies, and adds some pharmaceutically acceptable excipients or carriers.

[0040]

Preparation of Chinese Medicine Extract for Protecting the Liver and Relieving Alcoholism

[0041] Prepare the Chinese medicine preparation for protecting the liver and relieving alcoholism according to the formula listed in Table 1. The specific preparation method is as follows:

[0042] (1) Prepare materials according to the formula, mix Ganoderma lucidum, Hippohgae rhamnoides, Hovenia acerba, Pueraria lobata, malt, hawthorn, longan pulp, American ginseng, Dendrobium officinale, and saffron, then pulverize and pass through an 80-mesh sieve to obtain fine powder for standby;

[0043] (2) Extract the obtained fine powder with about 10 times of deionized water for 3 times, about 1 hour each time, then filter, concentrate the filtrate, dry at low temperature, and pulverize again to obtain the Chinese medicine extract;

[0044] (3) Mix the Chinese medicine extract with honey and an appropriate amount of water to make a liquid preparation.

[0045] According to the above method, liver-protecting and hangover-relieving preparation samples E1 to E3 and comparative samples D1 to D5 were obtained respectively.

[0046] Table 1 Formulations of each group in the examples and comparative examples (unit: g)

[0047] Component E1 E2 E3 D1 D2 D3 D4 D5 Ganoderma lucidum 20 18 21 -- 20.8 20.8 24.3 23 Hippohgae rhamnoides 19 18 21 24 -- 23.7 23.2 22 Hovenia acerba 19 21 18 24 23.7 -- 23.2 22 Pueraria lobata 17 21 15 22 21.8 21.8 -- 20 Fructus Hordei Germinatus 12 9 13 17 16.7 16.7 16.3 -- Fructus Crataegi 2 2 2 2 2 2 2 2 Arillus Longan 1 1 1 1 1 1 1 1 American ginseng 1 1 1 1 1 1 1 1 Dendrobium officinale 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Crocus sativus 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Honey 1 1 1 1 1 1 1 1

[0048]

Hangover effect test

[0049] For the samples E1 to E3 and D1 to D5 obtained from the above examples and comparative examples, the hangover effect of the formulated composition on drunken mice was evaluated through experiments, and the drunken symptoms and hangover time of the mice were rated by gavage administration.

[0050] (1) Experimental materials

[0051] Experimental animals: Healthy male ICR mice with a body weight of 20 ± 2 g were selected.

[0052] Alcohol: 53° Maotai-flavor Baijiu.

[0053] Experimental consumables: Electronic scale, timer, 1 mL syringe, 8-gauge gavage needle.

[0054] (2) Experimental method

[0055] Establishment and grouping of the mouse drunken model: The mice were randomly divided into 4 groups, with 11 mice in each group, namely the drunken model group, low-dose group (250 mg / kg), medium-dose group (500 mg / kg), and high-dose group (1 g / kg). The mice were fasted for 12 h before the experiment without water restriction. After the mice in the model group and each dose group were pre-treated with the same dose of purified water and the composition for 20 min respectively, all the mice were gavaged with 15 mL / kg of Baijiu to make them reach the drunken state. If the righting reflex of the mice disappeared within 30 s, it was considered that the mice entered the drunken state.

[0056] Determination of the hangover time: Taking the time when the righting reflex of the mice disappeared as the node, the mice were turned over with their abdomens facing up. If they could not recover the righting within 30 s, it was considered that the righting reflex disappeared, indicating that the mice entered the drunken state. Record the time when the mice entered the drunken state until the righting disappearance was restored. This time period was recorded as the hangover duration of the mice.

[0057] Establishment and grouping of the mouse ethanol intoxication model: The mice were randomly divided into 4 groups, with 10 mice in each group, namely the ethanol intoxication model group, the low-dose group (250 mg / kg), the medium-dose group (500 mg / kg), and the high-dose group (1 g / kg). The mice were fasted for 12 h before the experiment without water restriction. After the mice in the model group and each dose group were pre-treated with the same dose of pure water and the composition for 20 min respectively, all the mice were gavaged with 20 mL / kg of white liquor, and their survival status was observed.

[0058] Statistical analysis method: SPSS 26.0 statistical software was used for analysis. All results were expressed as mean ± standard deviation (x±s). For comparison among multiple groups of data, one-way analysis of variance (One-Way ANOVA) was used. When P<0.05, it indicated that there was a statistical difference between the two groups; when P<0.01, it indicated that there was a significant difference between the two groups; when P<0.001, it indicated that there was a highly significant difference between the two groups. Homogeneity test for variance homogeneity was performed. If the variances were homogeneous, the least significant difference method (LSD) was used for testing; if the variances were not homogeneous, Dunnett’s T3 test was used.

[0059] (3) Experimental results

[0060] The experimental test results of the effects of each traditional Chinese medicine composition on the ethanol-alleviating duration in mice are shown in Table 2.

[0061] Table 2 Test results of the ethanol-alleviating duration in mice (min)

[0062]

[0063]

[0064] Note: The data of the model group are the same as those of sample E1; * P < 0.05, ** P < 0.01, *** P < 0.001.

[0065] As can be seen from Table 2, compared with the model group, all samples of the embodiments of the present invention showed significant hangover effects, and the effects were better than those of the comparative examples. In the comparative examples, when a certain component was missing while the total weight of the traditional Chinese medicine main ingredients (Ganoderma lucidum, Hippohgae rhamnoides, Hovenia dulcis, Pueraria lobata, and malt) remained unchanged, the hangover effect deteriorated. This indicates that the prescription of Ganoderma lucidum, Hippohgae rhamnoides, Hovenia dulcis, Pueraria lobata, and malt provided by the present invention has a synergistic effect and achieves excellent effects through the traditional Chinese medicine mechanism of "emperor, minister, assistant, and guide". In the embodiments, the effect of sample E1 was the best. The average awakening time of mice in the sample E1 group was 301 min compared with the model group, and the average awakening time of mice in the low-dose group was 166 min. Compared with the model group, the hangover time of mice was significantly shortened, with a significant difference (P < 0.05). The average hangover times of the medium-dose group and the high-dose group of the composition were 152 min and 134 min respectively. Compared with the model group, the hangover time of mice could be significantly shortened, with a highly significant difference (P < 0.01).

[0066] Taking sample E1 of the liver-protecting and hangover-relieving preparation of the present invention as an example, the effect of the sample on the survival rate of dead-drunk mice was further tested. The experimental results are shown in Figure 1 . As Figure 1 can be seen, in the model group without drug intervention, the mortality rate was as high as 60%. After the intervention with the low-dose composition, the mortality rate of mice decreased by 20% compared with the model group. After the intervention with the medium-dose and high-dose compositions, the mortality rate of mice decreased to 10% compared with the model group, and the survival rate was as high as 90%. The experimental results show that composition E1 can significantly shorten the hangover time of drunk mice, effectively reduce the death of mice caused by alcohol poisoning, and reduce the damage of alcohol to the mouse body.

[0067] Taking sample E1 of the liver-protecting and hangover-relieving preparation of the present invention as an example, it was tested with 50 - 150 ml of high-proof liquor. When the tester was in good health and not drunk, a few minutes after drinking, the alcohol data was about 100 or more. After taking the oral preparation (about 30 ml), the alcohol content test data result was about 15 - 35 or so. When drinking to half, the drinker did not show a too high heart rate or a rapid and forceful pulse, and there was no discomfort in the heart or the discomfort was greatly reduced. For those who did not take the oral preparation, the heart rate was more than 10 beats higher.

[0068] The liver-protecting and hangover-relieving preparation of the present invention can effectively protect the gastrointestinal tract of drinkers, reduce stomach discomfort, diarrhea, etc. When a drinker has stomach discomfort, after taking the oral preparation of the present invention, the stomach discomfort can be quickly adjusted.

[0069] The present invention also has the effects of calming the mind and refreshing the brain, reducing restlessness and agitation after drinking, dispelling hangover, and quickly relieving hangover. It can enable the rapid metabolism of alcohol, protect the heart and gastrointestinal tract, can quickly relieve hangover and calm the mind, have a good sleep, and there is no discomfort or hangover when waking up the next day.

[0070] The above description of the embodiments is provided to enable those of ordinary skill in the art to understand and use the invention. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative efforts. Therefore, the present invention is not limited to the above embodiments, and all improvements and modifications made by those skilled in the art without departing from the scope of the present invention according to the disclosure of the present invention should be within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for protecting the liver and relieving hangover, characterized in that, The main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 15-25 parts of Ganoderma lucidum, 15-25 parts of Hippohgae rhamnoides, 15-25 parts of Hovenia acerba, 15-25 parts of Pueraria lobata, and 5-15 parts of malt.

2. The liver-protecting and hangover-relieving traditional Chinese medicine composition according to claim 1, characterized in that, The main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 18-21 parts of Ganoderma lucidum, 18-21 parts of Hippohgae rhamnoides, 18-21 parts of Hovenia acerba, 15-21 parts of Pueraria lobata, and 9-13 parts of malt.

3. The liver-protecting and hangover-relieving traditional Chinese medicine composition according to claim 1, wherein, The main ingredients of the traditional Chinese medicine composition for protecting the liver and relieving hangover are composed of the following raw materials in parts by weight: 20 parts of Ganoderma lucidum, 19 parts of Hippohgae rhamnoides, 19 parts of Hovenia acerba, 17 parts of Pueraria lobata, and 12 parts of malt.

4. The liver-protecting and hangover-relieving traditional Chinese medicine composition according to claim 1, characterized in that The liver-protecting and hangover-relieving composition further includes excipients, and the excipients are selected from one or more mixtures of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey.

5. The liver-protecting and hangover-relieving traditional Chinese medicine composition according to claim 4, characterized in that, The excipients are composed of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey. By weight, it is 1-3 parts of hawthorn, 0.5-1.5 parts of longan pulp, 0.5-1.5 parts of American ginseng, 0.1-1 part of Dendrobium officinale, 0.1-1 part of saffron, and 0.5-1.5 parts of honey.

6. The liver-protecting and hangover-relieving traditional Chinese medicine composition according to claim 4, characterized in that, The excipients are composed of hawthorn, longan pulp, American ginseng, Dendrobium officinale, saffron, and honey. By weight, it is 2 parts of hawthorn, 1 part of longan pulp, 1 part of American ginseng, 0.5 part of Dendrobium officinale, 0.5 part of saffron, and 1 part of honey.

7. The preparation method of a traditional Chinese medicine composition for protecting the liver and relieving hangover according to any one of claims 1 to 6, characterized in that, It includes the following steps: (1) Crush Ganoderma lucidum, Hippohgae rhamnoides, Hovenia acerba, Pueraria lobata, malt, hawthorn, longan pulp, American ginseng, Dendrobium officinale, and saffron, and pass through a 60-100 mesh sieve to obtain fine powder for standby. (2) Extract the obtained fine powder with 8-15 times deionized water for 2-3 times, each time for 1-3 hours, filter, concentrate the filtrate, dry, and crush to obtain a traditional Chinese medicine extract. (3) Mix the traditional Chinese medicine extract with honey to make a preparation.

8. Use of a traditional Chinese medicine composition for protecting the liver and relieving hangover according to any one of claims 1 to 6, characterized in that, Application of the described traditional Chinese medicine composition in preparing a liver-protecting and hangover-relieving drug.

9. Use of a traditional Chinese medicine composition for protecting the liver and relieving hangover according to claim 8, characterized in that, The dosage form of the traditional Chinese medicine composition includes hard capsules, soft capsules, tablets, granules, powders, pills, or oral liquid preparations.

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