Traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy

Abstract

The invention discloses a traditional Chinese medicine composition for treating post-chemotherapy peripheral neuritis, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine is prepared from the following raw materials: astragalus membranaceus, cassia twig, radix paeoniae alba, ginger, Chinese dates, fried mustard seeds, angelica sinensis and caulis spatholobi. Comprising the following preparation steps: A, soaking: soaking required medicinal raw materials in cold water for 30-60 minutes, wherein the water is 2-3cm higher than the medicinal materials; wherein the fresh ginger is firstly sliced and then soaked, and the Chinese dates are braised and then soaked together; b, decocting: boiling with big fire, then turning to slow fire, keeping a slight boiling state, decocting for 20-25 minutes, filtering, and collecting liquid medicine; the traditional Chinese medicine composition has the effects of tonifying qi, harmonizing blood, reducing phlegm and dredging collaterals, and is remarkable in curative effect and small in side effect when being used for treating the peripheral neuritis after chemotherapy.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a drug related to the treatment of peripheral neuritis after chemotherapy. Background Art

[0002] Chemotherapy is one of the important means of cancer treatment. Peripheral neuritis caused by chemotherapy drugs (chemotherapy-induced peripheral neuropathy, CIPN) is a common and serious complication in tumor treatment, and its impact on patients is mainly reflected in the following aspects: 1. Sensory dysfunction: Symmetrical and persistent numbness at the extremities of the limbs. In severe cases, the patient is unable to perceive cold, heat or touch objects, and even a slight touch can cause severe pain.

[0003] 2. Motor dysfunction: Weakness in fingers, wrists and ankles, reduced grip strength (such as being unable to unscrew the bottle cap or hold the pen steadily), difficulty in lifting the feet when walking, and presenting a "dragging gait".

[0004] 3. Impact on daily life: Daily activities such as dressing, washing, and eating become difficult due to finger numbness or weakness. In severe cases, assistance from others is required. The safety of walking decreases, and it is easy to fall when going up and down stairs or on uneven roads.

[0005] 4. Occupational and social barriers: Occupations that rely on fine operations (such as teachers, doctors, and craftsmen) cannot work normally and may even be forced to interrupt their careers.

[0006] 5. Psychological and emotional impacts: Long-term chronic pain and dysfunction lead to anxiety and depression, reducing treatment compliance; some patients have a fear psychology because they are worried that the nerve damage is irreversible. It brings pain to patients and thus affects the quality of life.

[0007] Traditional Chinese medicine believes that peripheral neuritis after chemotherapy belongs to the categories of "blood bi" and "numbness". Chemotherapy drugs belong to the category of "drug toxins" in traditional Chinese medicine. They are extremely potent in nature, and long-term use will surely damage the spleen and stomach, qi and blood, yin and yang of the human body. Chemotherapy damages the spleen and stomach, resulting in dysfunction of transportation and transformation, stagnation of water and dampness in the body, and accumulation of dampness into phlegm (in "Plain Questions - Treatise on the Most Important Pathogenic Factors": "All cases of dampness, swelling, and fullness are attributed to the spleen"). Insufficient production of qi and blood, deficiency of qi leads to weak propulsion, and unsmooth blood circulation forms stasis; injury to yin leads to endogenous virtual fire, which scorches body fluids into phlegm (in "Correction of Errors in Medicine": "When body fluids are deficient, the inner membrane becomes dry and sticky, forming phlegm"). Phlegm follows the flow of qi and can reach everywhere. It combines with stasis, obstructs the meridians, and forms the syndrome of "phlegm and stasis obstructing the meridians", manifested as numbness, stabbing pain, paresthesia, etc. (in "Introduction to Medicine": "Phlegm stagnates in the middle jiao, hindering the ascent and descent, so it forms accumulations internally and swelling toxins externally. In severe cases, it leads to paralysis and epilepsy"). Therefore, its pathogenesis can be summarized as "drug toxins damaging healthy qi, phlegm and stasis interacting and binding, and meridians being obstructed". Its characteristics of long-term illness and complex symptoms exactly match the pathogenesis of "for long-term and miscellaneous diseases, strange diseases must have phlegm and stasis". Treatment needs to grasp the core of "phlegm and stasis interacting and binding, deficiency and excess being intermingled", with regulating ying and wei, qi and blood as the key, and concurrently resolving phlegm and removing stasis, in order to break the vicious cycle of "deficiency - phlegm - stasis", improve nerve function, and enhance the quality of life of patients.

[0008] Currently, the current situation of Western medicine treatment: 1. Nerve-nourishing drugs: Neurotrophic agents such as vitamin B1 and vitamin B12 (methylcobalamin) are commonly used drugs in clinical practice. They improve symptoms by supplementing substances required for nerve metabolism, but have limited efficacy for moderate to severe nerve damage, and may cause gastrointestinal reactions or allergies after long-term use. Limitations: Only targeting symptom relief, unable to reverse nerve pathological damage, and some patients are prone to recurrence after drug withdrawal.

[0009] 2. Symptomatic pain-relieving drugs: Antidepressants (such as duloxetine) and anticonvulsants (such as gabapentin) can relieve pain, but have significant side effects, such as drowsiness, dizziness, liver and kidney function damage, etc., and may interact with chemotherapy drugs. Limitations: Only applicable to patients with severe pain, unable to improve core symptoms such as numbness and paresthesia.

[0010] 3. Other Western medicines: Drugs such as amifostine and reduced glutathione reduce neurotoxicity through antioxidant mechanisms, but there is insufficient clinical evidence, and they may affect the efficacy of chemotherapy.

[0011] And the current situation of traditional Chinese medicine treatment: 1. Application of classical formulas: Huangqi Guizhi Wuwu Decoction: Originating from "Synopsis of the Golden Chamber", it is used to treat blood bi syndrome. Modern research shows that its active ingredient formononetin can activate the NRF2-GSTP1 pathway and reduce the neurotoxicity induced by oxaliplatin. However, this formula mainly focuses on warming yang and dredging collaterals, and has better efficacy for patients with qi and blood deficiency type, and limited effect on the type of deficiency and excess being intermingled, phlegm and stasis obstructing collaterals. Danggui Sini Decoction: It has the effects of nourishing blood and dispelling cold, warming the meridians and promoting blood circulation, and is commonly used for peripheral neuritis of the cold congealing and blood stasis type. However, asarum, tetrapanax papyriferus, etc. in the compatibility of medicinal materials may increase the burden on the liver and kidneys.

[0012] 2. Existing patents for Chinese medicine compositions: The patent formula of Hainan Provincial Hospital of Traditional Chinese Medicine contains: Angelica sinensis, white peony root, cinnamon twig, asarum, astragalus, processed aconite, etc., emphasizing warming yang and dispelling cold, promoting blood circulation and unblocking collaterals. However, processed aconite is highly toxic and the dosage needs to be strictly controlled, and the effect of the extraction process of medicinal materials on the efficacy is not clear. Wenluotongsan (achievement of the International Science and Technology Innovation Center): It is mainly an external dosage form (granules), prepared by water extraction, alcohol precipitation and warm immersion extraction, which can improve neuroelectrophysiological and histopathological changes. However, the absorption of external preparations is limited, and the improvement of systemic symptoms is weak.

[0013] 3. Other Chinese medicine prescriptions: Millettia reticulata, Astragalus, White Peony Root, and Angelica sinensis: Commonly used in clinical experience prescriptions, they focus on replenishing qi and blood, relaxing muscles and activating collaterals, but lack standardized research and have large differences in efficacy. Prescriptions for clearing heat and removing dampness: such as Kochia scoparia and Sophora flavescens, are suitable for patients with damp-heat type, but are not targeted enough for the pathogenesis of qi and blood deficiency after chemotherapy.

[0014] Traditional Chinese medicine treatment focuses on overall conditioning, and has certain advantages in relieving symptoms through syndrome differentiation and treatment, and adopts methods such as oral administration of Chinese medicine. However, the current Chinese medicine composition for peripheral neuritis after chemotherapy still has problems such as inaccurate prescriptions and the need to further improve the efficacy. Therefore, it is of great practical significance to develop a Chinese medicine composition for the treatment of peripheral neuritis after chemotherapy with significant efficacy and few side effects. Summary of the invention

[0015] The invention provides a traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy. The traditional Chinese medicine composition has the effects of invigorating qi and blood, resolving phlegm and dredging collaterals. The traditional Chinese medicine composition is used for treating peripheral neuritis after chemotherapy, which not only has significant therapeutic effect but also has small side effects.

[0016] In order to solve the above technical problems, the technical solution adopted by the present invention is as follows: It is made from the following raw materials: Astragalus, cinnamon twig, white peony root, ginger, jujube, fried mustard seeds, angelica, and Millettia reticulata.

[0017] In the above technical scheme, a more specific technical scheme is: the weight proportions of each raw material are as follows: 30 to 60 parts of astragalus, 10 to 30 parts of cinnamon twig, 10 to 30 parts of white peony root, 5 to 10 parts of ginger, 10 to 20 parts of jujube, 5 to 10 parts of fried mustard seeds, 5 to 15 parts of angelica, and 15 to 30 parts of Millettia reticulata.

[0018] Furthermore, the weight proportions of each raw material are as follows: 30 parts of astragalus, 15 parts of cinnamon twig, 15 parts of white peony root, 6 parts of ginger, 15 parts of jujube, 8 parts of stir-fried mustard seeds, 15 parts of angelica, and 30 parts of Millettia reticulata.

[0019] Furthermore, the weight parts of each raw material are as follows: 50 parts of Astragalus membranaceus, 15 parts of Ramulus Cinnamomi, 15 parts of Radix Paeoniae Alba, 8 parts of Zingiber officinale, 15 parts of Fructus Jujubae, 8 parts of Semen Sinapis Praeparatum, 10 parts of Angelica sinensis, and 20 parts of Caulis Spatholobi.

[0020] Furthermore, the weight parts of each raw material are as follows: 60 parts of Astragalus membranaceus, 30 parts of Ramulus Cinnamomi, 30 parts of Radix Paeoniae Alba, 10 parts of Zingiber officinale, 20 parts of Fructus Jujubae, 10 parts of Semen Sinapis Praeparatum, 15 parts of Angelica sinensis, and 30 parts of Caulis Spatholobi.

[0021] Furthermore, it includes the following preparation steps: A. Soaking: Soak the required medicinal raw materials in cold water for 30 - 60 minutes, with the water level 2 - 3 cm above the medicinal materials; among them, slice the Zingiber officinale first and then soak it, and split the Fructus Jujubae and then put them together for soaking. B. Decoction: After boiling over high heat, turn to low heat to maintain a slightly boiling state, decoct for 20 - 25 minutes, filter, and collect the decoction.

[0022] Furthermore, choose one of earthenware pots or ceramic pots to decoct the medicine.

[0023] Among them, the Astragalus membranaceus in the present invention is the root of Astragalus membranaceus of the genus Astragalus in the Fabaceae (Papilionaceae), which is sweet in taste, slightly warm in nature, and belongs to the spleen, lung, liver, and kidney meridians, with aliases such as Mianqi, Huangqi, Duzhen, Shuzhi, Baiben, Baiyaomian, Huangcan, Xueshen, Renxian, etc. The Zingiber officinale is the fresh rhizome of the plant Zingiber officinale of the Zingiberaceae family, slightly warm in nature, pungent in taste, and belongs to the lung, spleen, and stomach meridians, with aliases such as Jianggen, Bailayun, Gouzhuangzhi, Yindi Xin, Yanliang Xiaoz, Xianshengjiang, etc.

[0024] The Ramulus Cinnamomi is the dried tender branch of Cinnamomum cassia, a medium - sized arbor plant of the genus Cinnamomum in the Lauraceae family, which is pungent and sweet in taste, warm in nature, and belongs to the lung, heart, and bladder meridians, with the alias Liugui.

[0025] The Radix Paeoniae Alba is the dried root of the plant Paeonia lactiflora of the Ranunculaceae family, which is bitter and sour in taste, slightly cold in nature, and belongs to the liver and spleen meridians, with aliases such as Baishaoyao, Jinshaoyao.

[0026] The Zingiber officinale is the fresh rhizome of the plant Zingiber officinale of the Zingiberaceae family, slightly warm in nature, pungent in taste, and belongs to the lung, spleen, and stomach meridians, with aliases such as Jianggen, Bailayun, Gouzhuangzhi, Yindi Xin, Yanliang Xiaoz, Xianshengjiang, etc.

[0027] The Fructus Jujubae is a plant of the genus Ziziphus in the family Rhamnaceae of the order Rosales, which is warm in nature, sweet in taste, and belongs to the spleen and stomach meridians, with aliases such as Hongzao, Ganzao, Zaozi, Dazao, Meizao, Liangzao, Cizao, Danzao, etc.

[0028] The Semen Sinapis Praeparatum is processed from the dried and mature seeds of the plants Brassica alba or Brassica juncea of the Brassicaceae family, which is pungent in taste, warm in nature, and belongs to the lung meridian, with aliases such as Jiecaizi, Qingcaizi.

[0029] The Angelica sinensis is the root of Angelica sinensis of the Umbelliferae family. It has a sweet taste and a warm nature, and enters the liver, heart, and spleen meridians. Its aliases include Dry Angelica, Qinna, Western Angelica sinensis, Min Angelica sinensis, Golden Angelica sinensis, Angelica sinensis body, Angelica sinensis tail, Angelica sinensis curd, Native Angelica, Qin Angelica, Yun Angelica, Mountain Qi, White Qi, Wenwu.

[0030] The Caulis Spatholobi is the dried vine stem of Spatholobus suberectus Dunn of the Leguminosae family. It has a warm nature, a slightly bitter and sweet taste, and enters the liver, heart, and kidney meridians. Its aliases include Blood Wind Vine, Red Deer Vine, Red Vine, Activating Blood Vine, Blood Dragon Vine, Over-the-Hill Dragon, Purple Stem Vine, Pig Blood Vine, Nine-Layer Wind, Five-Layer Blood, Blood Wind, Blood Vine, Large Blood Vine, Three-Leaf Caulis Spatholobi, Blood Vein Vine, etc.

[0031] Due to the adoption of the above technical solution, the beneficial effects obtained by the present invention are as follows: 1. In the prescription of the present invention, Astragalus membranaceus is the monarch drug for invigorating qi and consolidating the exterior, laying the foundation for tonifying deficiency. Angelica sinensis, Caulis Spatholobi, and Paeonia lactiflora are the ministerial drugs for nourishing blood and promoting blood circulation, dredging the blocked collaterals. Stir-fried Semen Sinapis Albae, Ramulus Cinnamomi, and Ginger are the adjuvant drugs for resolving phlegm and warming the channels, breaking the mutual binding of phlegm and stasis. Jujube is the guiding drug for strengthening the spleen and regulating the middle, and coordinating all the drugs.

[0032] 2. The compatibility and synergistic effect of the prescription of the present invention are as follows: ①Combining supplementation and dredging, with appropriate balance between attack and supplementation: Supplementation: Astragalus membranaceus + Angelica sinensis + Paeonia lactiflora + Jujube, invigorating qi and nourishing blood, targeting the deficiency of "drug toxicity damaging the healthy qi"; Dredging: Caulis Spatholobi + Ramulus Cinnamomi + Stir-fried Semen Sinapis Albae + Ginger, promoting blood circulation and warming the channels, resolving phlegm and removing stasis, targeting the excess of "phlegm and stasis blocking the collaterals"; ②Regulating qi and blood simultaneously, treating phlegm and stasis concurrently: Treating qi and blood simultaneously: Astragalus membranaceus invigorates qi, Angelica sinensis and Paeonia lactiflora nourish blood, Ramulus Cinnamomi promotes yang circulation, achieving "qi sufficiency, blood abundance, and yang circulation", solving the problems of disharmony between qi and blood and yang not reaching the extremities. Resolving phlegm and stasis simultaneously: Stir-fried Semen Sinapis Albae resolves phlegm, Caulis Spatholobi removes stasis, and the combination of the two "treats phlegm and stasis concurrently", targeting the core pathological product of "phlegm and stasis mutual binding" after chemotherapy, especially suitable for patients with numbness, tingling, and phlegm and stasis blocking the collaterals; ③Guiding the drug into the collaterals and directly reaching the disease site: Both Caulis Spatholobi and Ramulus Cinnamomi are "collateral dredging drugs". The former is good at entering the blood aspect, and the latter is good at entering the qi aspect. The combination can penetrate qi and blood collaterals. Stir-fried Semen Sinapis Albae is pungent and dispersing, and can penetrate and move around. "Bencao Biandu" states that it "can directly reach between the pleural membranes, bones, and tendons", guiding all the drugs to penetrate deep into the disease site and enhancing the therapeutic effect on peripheral nerves; In summary, the prescription of the present invention closely adheres to the pathogenesis of "drug toxicity damaging the healthy qi, phlegm and stasis mutual binding, and collaterals obstruction" after chemotherapy, forming a compatibility feature of "invigorating qi without stagnation, promoting blood circulation without damaging the healthy qi, and resolving phlegm without consuming qi". The whole prescription integrates "supplementation, dredging, and resolving phlegm" into one, and is applicable to peripheral neuritis after chemotherapy, reflecting the treatment concepts of "treating the disease based on its root cause" and "treating both the symptoms and the root cause" in traditional Chinese medicine. Detailed implementation mode

[0033] The following further details the present invention in combination with specific embodiments: Example 1 - Traditional Chinese Medicine Composition for Treating Peripheral Neuritis after Chemotherapy The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy in this example is made from the following components by weight: Astragalus membranaceus 30 parts, Cinnamomum cassia 15 parts, Paeonia lactiflora 15 parts, Zingiber officinale 6 parts, Ziziphus jujuba 15 parts, Sinapis alba 8 parts, Angelica sinensis 15 parts, Spatholobus suberectus 30 parts; Its preparation method is as follows: 1.1 Soaking Preferably use earthenware pots or ceramic pots (avoid metal containers such as iron and aluminum to prevent chemical reactions with drug components). Soak each raw medicinal material in cold water for 30 - 60 minutes, and the water volume should be appropriate to submerge the medicinal materials by 2 - 3 cm (about 600 - 800 ml); among them, slice the ginger before soaking, and split the jujubes to facilitate the dissolution of active ingredients; 1.2 Decoction After boiling over high heat, turn to low heat (slow fire) to maintain a slightly boiling state and decoct for 20 - 25 minutes (Cinnamomum cassia contains volatile oil and should not be decocted for a long time to avoid the loss of medicinal effects); Administration method: Take 1 dose per day, decoct with water to obtain 200 - 400 ml of juice, take it in two divided doses in the morning and evening, 1 week is a course of treatment, and continuously treat for 4 - 8 courses of treatment.

[0034] Example 2 - Traditional Chinese Medicine Composition for Treating Peripheral Neuritis after Chemotherapy The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy in this example is made from the following components by weight: Astragalus membranaceus 50 parts, Cinnamomum cassia 15 parts, Paeonia lactiflora 15 parts, Zingiber officinale 8, Ziziphus jujuba 15 parts, Sinapis alba 8 parts, Angelica sinensis 10 parts, Spatholobus suberectus 20 parts. Use the above traditional Chinese medicine composition as the active ingredient to make a decoction, and its preparation method is: its preparation method and administration method are the same as those in Example 1.

[0035] Example 3 - Traditional Chinese Medicine Composition for Treating Peripheral Neuritis after Chemotherapy The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy in this example is made from the following components by weight: Astragalus membranaceus 60 parts, Cinnamomum cassia 30 parts, Paeonia lactiflora 30 parts, Zingiber officinale 10 parts, Ziziphus jujuba 20 parts, Sinapis alba 10 parts, Angelica sinensis 15 parts, Spatholobus suberectus 30 parts. Use the above traditional Chinese medicine composition as the active ingredient to make a decoction, and its preparation method is: its preparation method and administration method are the same as those in Example 1.

[0036] Effect test part: Comparative analysis of TCM syndrome score data from clinical retrospective cases: The following data are clinical review data. Patients who visited the oncology department from January 1, 2023 to December 30, 2024 and were diagnosed with a combination of deficiency and excess, and the intermingling of phlegm and stasis after chemotherapy were selected. The prescription used was: Astragalus membranaceus 30g, Cinnamomum cassia 15g, Paeonia lactiflora 15g, Zingiber officinale 6g, Ziziphus jujuba 15g, Sinapis alba 8g, Angelica sinensis 15g, Spatholobus suberectus 30g. One dose was taken daily, the juice was extracted by decocting in water to obtain 200 - 400 ml, and it was taken twice, in the morning and evening. One week was one course of treatment, and continuous treatment was carried out for 4 - 8 courses. The comparative analysis of the TCM syndrome score data before and after treatment is shown in Table 1 (Main syndrome score: Limb numbness: No numbness is 0 points; Occasional numbness without affecting life is 2 points; Frequent numbness with a certain impact on life is 4 points; Severe and persistent numbness seriously affecting life is 6 points).

[0037] Table 1 Comparative analysis of TCM syndrome score data before and after treatment 。

[0038] Specific case introduction: (1) Patient Liu, male, 58 years old Current medical history: The patient reported that he had abdominal pain without obvious cause in December 2022. The pain was tolerable and he didn't pay attention. Later, the pain gradually worsened, so he went to Liuzhou Workers' Hospital for treatment. After completing the examinations and excluding contraindications, he underwent radical resection of the left colon in the hospital on April 10, 2023. The postoperative pathology showed: (Left colon) adenocarcinoma. No vascular cancer thrombus or nerve invasion was seen. The (proximal resection margin), (distal resection margin), and circumferential resection margin were not involved in cancer. 42 lymph nodes were seen in the pericolonic fat, and 1 lymph node had cancer metastasis (1 / 42); The greater omentum was not involved in cancer, 9 lymph nodes were seen, and no cancer metastasis was found (0 / 9). After postoperative recovery, he was discharged. The discharge diagnosis was: Left colon cancer pT3N1M0. The patient completed 6 cycles of mfolfox6 regimen chemotherapy in our department from May 4, 2023 to July 18, 2023. The patient reported that he gradually developed symmetrical and persistent numbness at the extremities of the limbs from the end of the second cycle of chemotherapy, which was worse when exposed to cold and gradually worsened. In severe cases, he couldn't perceive cold or heat or touch objects. At the same time, he was accompanied by fatigue and drowsiness, without aversion to cold and fever, nausea and vomiting, poor appetite, normal sleep, and normal bowel and bladder movements. The tongue was pale and dull, the tongue coating was white and thick and greasy, there were ecchymoses under the tongue, and the pulse was thin and unsmooth.

[0039] Diagnosis: Intestinal cancer Combination of deficiency and excess, intermingling of phlegm and stasis Treatment principle: Tonifying qi and promoting blood circulation, resolving phlegm and dredging collaterals.

[0040] Prescription: Astragalus membranaceus 30g, Cinnamomum cassia 15g, Paeonia lactiflora 15g, Zingiber officinale 6g, Ziziphus jujuba 15g, Sinapis alba 8g, Angelica sinensis 15g, Spatholobus suberectus 30g. One dose was taken daily, the juice was extracted by decocting in water to obtain 400 ml, and it was taken twice, in the morning and evening. One week was one course of treatment, and continuous treatment was carried out for 4 courses.

[0041] Therapeutic effect: After treatment, the symmetrical and persistent numbness at the extremities of the patient improved significantly, and there was slight numbness in the fingers when touching cold water. The tongue was pale red, and the ecchymosis under the tongue was reduced, with remarkable effects.

[0042] (2) Patient Liu, female, 69 years old Current medical history: The patient reported that on November 8, 2022, due to "right breast mass", she underwent right breast puncture biopsy at Liuzhou Maternal and Child Health Hospital, and the pathological result was invasive ductal carcinoma, grade II. Immunohistochemistry was further improved: ER (strong positive, 95%), PR (moderate to strong positive, 80%), C-erbB-2 (0). CT showed high-density shadows in multiple thoracic and lumbar vertebrae and appendages, suggesting possible metastatic tumors. The diagnosis was: right breast invasive carcinoma with endocrine therapy (cT4N1M1, stage IV, Luminal B type). From November 12, 2022 to March 2023, she received 6 cycles of TE regimen chemotherapy, and after the chemotherapy, palbociclib + exemestane endocrine therapy was given. The patient reported that bilateral toe numbness and swelling pain occurred after the end of the 2nd cycle of chemotherapy, and it gradually became significantly aggravated when touching cold water or walking barefoot on the floor, affecting sleep. She felt fatigued, had normal appetite, and normal bowel and bladder functions. The tongue was pale and dull, plump with tooth marks, the tongue coating was thin, white and greasy, and the pulse was slippery.

[0043] Diagnosis: Breast cancer Mixture of deficiency and excess, intermingling of phlegm and stasis Treatment principle: Tonify qi and activate blood circulation, resolve phlegm and dredge collaterals.

[0044] Prescription: Astragalus membranaceus 30g, Cinnamon twig 15g, White peony root 15g, Fresh ginger 6g, Chinese date 15g, Stir-fried mustard seed 10g, Angelica sinensis 15g, Spatholobus suberectus 30g. Take 1 dose daily, decoct with water to obtain 400 ml of juice, take it in two divided doses in the morning and evening, 1 week as a course of treatment, and continuously treat for 8 courses.

[0045] Therapeutic effect: After treatment, the bilateral toe numbness and swelling pain disappeared in the patient, with remarkable effects.

[0046] (3) Patient Tang, female, 66 years old Present illness history: The patient reported that in early December 2023, there was intermittent abdominal distension and pain in the lower abdomen, mainly in the left lower abdomen. So the patient went to Liuzhou People's Hospital for treatment. The abdominal CT showed: a huge cystic-solid mass in the pelvic cavity, considering a malignant tumor lesion of ovarian epithelial origin, abdominal and pelvic effusion, considering ovarian cancer. Excluding surgical contraindications, on January 4, 2024, the patient was sent to the operating room for total hysterectomy + pelvic lymph node dissection + para-aortic lymph node dissection + omentectomy + bilateral ovariectomy under general anesthesia. The postoperative pathology showed: there was necrosis in the small area of clear cell carcinoma of the left ovary, calcification was visible, no vascular cancer thrombus was seen in the section, no nerve invasion was seen, and no cancer invasion was seen in the fallopian tube. Immunohistochemistry: CK(+)CK7(+), NapsinA(+), P504S(+)PAX-8(+)P6(+)P53(+), ki(+30%)PR(-).ER(-)CK20(-)SALL4(-)WT-1(-)CD34(-), D2(-). The patient was diagnosed with stage IC clear cell carcinoma of the left ovary and completed 6 cycles of TC regimen chemotherapy from March 15, 2024 to July 10, 2024. After the chemotherapy, the weight decreased by about 15 Kg. The patient reported that bilateral lower limb contralateral numbness occurred after the end of the 3rd cycle of chemotherapy, mainly at the distal ends of the toes, accompanied by drowsiness, fatigue, tastelessness in the mouth, loss of appetite, dull pain in the epigastrium, poor appetite and sleep, and normal bowel and bladder movements. The tongue was pale, the tongue coating was white and greasy, and the pulse was deep, thin and stringy.

[0047] Diagnosis: Abdominal mass Mixture of deficiency and excess, intermingling of phlegm and stasis Treatment principle: Tonify qi and activate blood circulation, resolve phlegm and dredge collaterals.

[0048] Prescription: Astragalus membranaceus 30g, Cinnamon twig 15g, White peony root 15g, Fresh ginger 6g, Chinese date 15g, Stir-fried mustard seed 8g, Angelica sinensis 15g, Millettia reticulata 30g. Take 1 dose per day, decoct to get 400 ml of juice, take it twice in the morning and evening, 1 week as a course of treatment, and continuously treat for 6 courses.

[0049] Efficacy: After treatment, the bilateral lower limb contralateral numbness of the patient basically disappeared, and there was slight numbness when washing feet with tap water occasionally. There was no drowsiness, fatigue, or dull pain in the epigastrium, and the appetite and sleep were normal. The effect was remarkable.

[0050] It should be noted that: The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; Although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: They can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; And these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy, characterized in that Prepared from the following raw materials: Astragalus membranaceus, Cinnamomum cassia, Paeonia lactiflora, Zingiber officinale, Ziziphus jujuba, stir-fried Semen Sinapis, Angelica sinensis, Spatholobus suberectus.

2. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 1, wherein The weight parts of each raw material are as follows: Astragalus membranaceus 30 parts to 60 parts, Cinnamomum cassia 10 parts to 30 parts, Paeonia lactiflora 10 parts to 30 parts, Zingiber officinale 5 parts to 10 parts, Ziziphus jujuba 10 parts to 20 parts, stir-fried Semen Sinapis 5 parts to 10 parts, Angelica sinensis 5 parts to 15 parts, Spatholobus suberectus 15 parts to 30 parts.

3. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 2, wherein The weight parts of each raw material are as follows: Astragalus membranaceus 30 parts, Cinnamomum cassia 15 parts, Paeonia lactiflora 15 parts, Zingiber officinale 6 parts, Ziziphus jujuba 15 parts, stir-fried Semen Sinapis 8 parts, Angelica sinensis 15 parts, Spatholobus suberectus 30 parts.

4. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 2, wherein The weight parts of each raw material are as follows: Astragalus membranaceus 50 parts, Cinnamomum cassia 15, Paeonia lactiflora 15 parts, Zingiber officinale 8, Ziziphus jujuba 15 parts, stir-fried Semen Sinapis 8 parts, Angelica sinensis 10 parts, Spatholobus suberectus 20 parts.

5. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 2, wherein The weight parts of each raw material are as follows: Astragalus membranaceus 60 parts, Cinnamomum cassia 30 parts, Paeonia lactiflora 30 parts, Zingiber officinale 10 parts, Ziziphus jujuba 20 parts, stir-fried Semen Sinapis 10 parts, Angelica sinensis 15 parts, Spatholobus suberectus 30 parts.

6. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 1 or 2 or 3 or 4 or 5, characterized in that Including the following preparation steps: A. Soaking: Soak the required medicinal raw materials in cold water for 30 to 60 minutes, with the water level 2 to 3 cm above the medicinal materials; among them, Zingiber officinale is sliced first and then soaked, and Ziziphus jujuba is split and then put in for soaking together. B. Decocting: After boiling over high heat, turn to low heat to keep it in a slightly boiling state, decoct for 20 to 25 minutes, filter, and collect the medicinal liquid.

7. The traditional Chinese medicine composition for treating peripheral neuritis after chemotherapy according to claim 6, characterized in that: Select one of earthenware pots or ceramic pots to decoct the medicine.