Unique preparation method of heart-protecting honey medicinal tea

Abstract

The invention relates to the field of medicinal tea preparation, and particularly discloses a heart-protecting honey medicinal tea unique preparation method, which comprises: 1, raw material pretreatment: mixing traditional Chinese medicine compositions according to a mass ratio, and crushing until the particle size is less than or equal to 0.5 mm, the traditional Chinese medicine composition is prepared from the following components in parts by mass: 5 to 10 parts of radix salviae miltiorrhizae, 8 to 15 parts of fructus crataegi, 3 to 6 parts of radix notoginseng, 5 to 10 parts of radix astragali seu hedysari, 4 to 8 parts of semen cassiae, 4 to 5 parts of flos rosae rugosae, 6 to 12 parts of poria cocos, 4 to 10 parts of fructus lycii and 2 to 5 parts of radix angelicae dahuricae. Step 2, carrying out sectional gradient extraction; the traditional Chinese medicine active ingredients such as tanshinone, notoginsenoside, astragalus polysaccharide and the like are added, so that the heart-protecting honey medicinal tea has excellent performance in the aspects of myocardial injury improvement, oxidation resistance and inflammation resistance; by adding beautifying components such as collagen peptide, vitamin C microcapsules, aloe polysaccharide, dipotassium glycyrrhizinate and the like, the heart-protecting honey medicinal tea has remarkable effects in beautifying aspects such as oxidation resistance, moisture retention, collagen synthesis promotion, inflammation resistance and the like.

Description

Technical Field

[0001] The invention belongs to the field of medicinal tea preparation, in particular to a unique preparation method of heart-protecting honey medicinal tea. Background Art

[0002] The history of honey medicinal tea can be traced back to ancient times, and similar drinks exist in different cultures. The ancient Egyptians mixed honey with herbs to treat various diseases; in traditional Chinese medicine, there are also records of using honey with Chinese medicinal materials to regulate the body and prevent and treat diseases.

[0003] Traditional honey medicinal teas are mostly made of honey combined with common herbal tea ingredients, such as chrysanthemum, wolfberry, rose, etc., and mainly focus on the effects of clearing away heat and reducing internal heat, relieving liver depression, and beautifying the skin. However, its effect on heart health is relatively limited. With the accelerated pace of life and increased work pressure, the incidence of heart disease has increased year by year, and traditional honey medicinal teas are difficult to meet people's needs for heart health. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a unique preparation method of heart-protecting honey medicinal tea to solve the problem that traditional honey medicinal tea in the prior art is difficult to meet people's needs for heart health care.

[0005] A unique preparation method of heart-protecting honey medicinal tea, comprising the following steps:

[0006] Step 1: Raw material pretreatment:

[0007] The Chinese medicine composition is mixed and crushed to a particle size of ≤0.5 mm according to the mass ratio. The components of the Chinese medicine composition are calculated by mass:

[0008] 5-10 parts of salvia miltiorrhiza, 8-15 parts of hawthorn, 3-6 parts of notoginseng, 5-10 parts of astragalus, 4-8 parts of cassia seed, 4-5 parts of rose, 6-12 parts of poria, 4-10 parts of wolfberry, 2-5 parts of angelica dahurica;

[0009] Step 2: Segmented gradient extraction:

[0010] The first stage: the crushed Chinese medicine composition is mixed with purified water at a mass ratio of 1:10-15, and ultrasonic-assisted extraction is performed at 40-50°C, and β-cyclodextrin is simultaneously added to embed rose volatile oil at a total mass concentration of 0.1-0.3%, and the conditions of the ultrasonic-assisted extraction are 25-40kHz for 30 minutes;

[0011] The second stage: heating to 60-65°C, adding compound enzyme for constant temperature enzymolysis for 50-70 minutes, wherein the compound enzyme includes 0.5% cellulase and 0.3% pectinase in total weight;

[0012] Step 3. Low-temperature compounding and activity retention:

[0013] The extract is concentrated under reduced pressure to 1 / 4 of the original volume and cooled to below 45°C to obtain a concentrated solution.

[0014] Honey and beauty active additives are added. The beauty active additives are 1.5 - 3 parts of collagen peptide and 0.5 - 1 part of vitamin C microcapsule. The mass ratio of honey to the concentrated solution is 1:4 - 6, and they are stirred and mixed under nitrogen protection.

[0015] Step 4. Directional sterilization and stabilization:

[0016] After ultra-high pressure instantaneous sterilization, 0.05 - 0.1% of natural preservative tea polyphenol based on the total mass is added, and it is aseptically filled into a freeze-dried granule dosage form. The ultra-high pressure instantaneous sterilization conditions are 350 - 400 MPa for 3 minutes.

[0017] Preferably, the traditional Chinese medicine composition further includes 2 - 5 parts of aloe gel extract and 0.2 - 0.5 parts of dipotassium glycyrrhizinate.

[0018] Preferably, in Step 2, the operation of β-cyclodextrin inclusion of rose volatile oil is carried out separately before ultrasonic extraction, the inclusion temperature is 35 - 40°C, and the inclusion rate ≥ 85%.

[0019] Preferably, in Step 3, the collagen peptide is a low-molecular-weight peptide derived from fish scales, and is added after being premixed with vitamin C microcapsules at a mass ratio of 3:1. The molecular weight of the low-molecular-weight peptide ≤ 1000 Da.

[0020] Preferably, when preparing the freeze-dried granule dosage form, 2 - 5% of maltodextrin based on the total liquid mass is added as a freeze-drying protectant. The freeze-drying procedure is: pre-freezing at -40°C for 2 hours, sublimation drying with a gradient temperature rise from -20°C to 0°C, and the water content of the final product ≤ 5%.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] By adding traditional Chinese medicine active ingredients such as tanshinone, notoginsenoside, and astragalus polysaccharide, the heart-protecting honey medicinal tea shows excellent performance in improving myocardial injury, antioxidant and anti-inflammatory aspects. In animal experiments, compared with the control group, the group of Example 2 can significantly reduce the levels of myocardial injury markers CK-MB and LDH, reduce myocardial cell damage, and the heart pathology score shows a significant reduction in the myocardial necrosis area. At the same time, its antioxidant and anti-inflammatory effects are significant, the SOD activity returns to near the normal level, the MDA level is significantly reduced, and the inflammatory factors TNF-α and IL-6 decrease significantly, effectively improving myocardial ischemia injury, inhibiting oxidative stress and inflammatory reactions, and providing strong support for heart health;

[0023] By adding beauty ingredients such as collagen peptides, vitamin C microcapsules, aloe polysaccharides, and dipotassium glycyrrhizinate, the heart-protecting honey herbal tea has remarkable effects in terms of beauty such as antioxidant, moisturizing, promoting collagen synthesis, and anti-inflammatory. Through animal experiment comparison, it was found that in the skin barrier repair of the second embodiment group, the transepidermal water loss decreased and the water content of the stratum corneum recovered well; in terms of antioxidant and anti-photoaging, the SOD activity increased significantly and the MDA content decreased; the collagen synthesis increased and the hydroxyproline content was close to the normal level; the anti-inflammatory and anti-wrinkle effects were significant, and the levels of IL-1β and MMP-1 decreased significantly, which could significantly improve the skin barrier function, inhibit photoaging and inflammatory reactions, and make the skin glow. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is the preparation flow chart of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0025] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

[0026] As Figure 1 shown:

[0027] Example 1:

[0028] A unique preparation method of a heart-protecting honey herbal tea, including raw material composition:

[0029] 5 parts of Salvia miltiorrhiza, 8 parts of Hawthorn, 3 parts of Notoginseng, 5 parts of Astragalus membranaceus, 4 parts of Cassia obtusifolia, 4 parts of Rosa rugosa, 6 parts of Poria cocos, 4 parts of Lycium barbarum, 2 parts of Angelica dahurica, 2 parts of aloe gel extract, 0.2 part of dipotassium glycyrrhizinate.

[0030] Preparation steps:

[0031] Raw material pretreatment:

[0032] Mix and crush the above traditional Chinese medicine composition to a particle size ≤ 0.5 mm.

[0033] Segmented gradient extraction:

[0034] The first stage: Mix the crushed material with pure water at a ratio of 1:10, and perform ultrasonic-assisted extraction at 40 °C (25 kHz, 30 minutes), and simultaneously add 0.1% β-cyclodextrin to embed the volatile oil of Rosa rugosa (embedding temperature 35 °C, embedding rate 85%).

[0035] The second stage: Heat up to 60 °C, add 0.5% cellulase + 0.3% pectinase, and perform constant-temperature enzymatic hydrolysis for 50 minutes.

[0036] Low-temperature compounding and activity retention:

[0037] The extract is concentrated under reduced pressure to 1 / 4 of the original volume and cooled to 40 °C.

[0038] Add honey (concentrate: honey = 4:1), 1.5 parts of fish scale collagen peptide (molecular weight ≤ 1000 Da), and 0.5 part of vitamin C microcapsule (pre-mixing ratio 3:1), and stir under nitrogen protection.

[0039] Directional sterilization and stabilization:

[0040] Ultra-high pressure sterilization (350 MPa, 3 minutes), add 0.05% tea polyphenols.

[0041] Add 2% maltodextrin, freeze-drying procedure: pre-freezing at -40 °C (2 hours), sublimation drying (gradient heating from -20 °C to 0 °C), and the water content of the final product ≤ 5%.

[0042] Example 2:

[0043] A unique preparation method of a heart-protecting honey medicinal tea, including raw material composition:

[0044] 7.5 parts of Salvia miltiorrhiza, 11.5 parts of Hawthorn fruit, 4.5 parts of Panax notoginseng, 7.5 parts of Astragalus membranaceus, 6 parts of Cassia obtusifolia, 4.5 parts of Rosa rugosa, 9 parts of Poria cocos, 7 parts of Lycium barbarum, 3.5 parts of Angelica dahurica, 3.5 parts of aloe gel extract, 0.35 part of dipotassium glycyrrhizinate.

[0045] Preparation steps:

[0046] Raw material pretreatment: The same as in Example 1.

[0047] Segmented gradient extraction:

[0048] First stage: The crushed material is mixed with pure water at a ratio of 1:12.5, and ultrasonic extraction is carried out at 45 °C (32.5 kHz, 30 minutes), and 0.2% β-cyclodextrin is simultaneously added to encapsulate the volatile oil (encapsulation temperature 37.5 °C, encapsulation rate 88%).

[0049] Second stage: Heat up to 63 °C and carry out enzymatic hydrolysis for 60 minutes.

[0050] Low-temperature compounding and activity retention:

[0051] Add honey (concentrate: honey = 5:1), 2.25 parts of collagen peptide + 0.75 part of vitamin C microcapsule (pre-mixing 3:1).

[0052] Directional sterilization and stabilization:

[0053] Ultra-high pressure sterilization (375 MPa, 3 minutes), add 0.075% tea polyphenols.

[0054] Add 3.5% maltodextrin, and the freeze-drying procedure is the same as that in Example 1.

[0055] Example 3:

[0056] A unique preparation method of a heart-protecting honey medicinal tea, including raw material composition:

[0057] 10 parts of Salvia miltiorrhiza, 15 parts of Hawthorn fruit, 6 parts of Notoginseng, 10 parts of Astragalus membranaceus, 8 parts of Cassia obtusifolia, 5 parts of Rosa rugosa, 12 parts of Poria cocos, 10 parts of Lycium barbarum, 5 parts of Angelica dahurica, 5 parts of aloe gel extract, 0.5 part of dipotassium glycyrrhizinate.

[0058] Preparation steps:

[0059] Raw material pretreatment: The same as in Example 1.

[0060] Segmented gradient extraction:

[0061] The first stage: The crushed material is mixed with pure water at a ratio of 1:15, and ultrasonic extraction is carried out at 50°C (40 kHz, 30 minutes), and 0.3% β-cyclodextrin is added simultaneously to encapsulate volatile oil (encapsulation temperature 40°C, encapsulation rate 90%).

[0062] The second stage: Heat up to 65°C and carry out enzymatic hydrolysis for 70 minutes.

[0063] Low-temperature compounding and activity retention:

[0064] Add honey (concentrate: honey = 6:1), 3 parts of collagen peptide + 1 part of vitamin C microcapsule (pre-mixed at a ratio of 3:1).

[0065] Directional sterilization and stabilization:

[0066] Ultra-high pressure sterilization (400 MPa, 3 minutes), and add 0.1% tea polyphenols.

[0067] Add 5% maltodextrin, and the freeze-drying procedure is the same as that in Example 1.

[0068] Example 4: Verify through experiments that our heart-protecting honey medicinal tea has a heart-protecting effect

[0069] I. Experimental purpose

[0070] Verify the differences between our heart-protecting honey medicinal tea (Example 2) and a common honey medicinal tea without heart-protecting effect (control group) in improving myocardial injury, antioxidant and anti-inflammatory effects.

[0071] II. Preparation process of the control group

[0072] Control group formula:

[0073] Remove the heart-protecting active ingredients: It does not contain traditional Chinese medicine compositions such as Salvia miltiorrhiza, Hawthorn Fruit, Panax notoginseng, Astragalus membranaceus, Cassia obtusifolia, Poria cocos, Lycium barbarum, and Angelica dahurica.

[0074] Retain the basic ingredients: Honey (equivalent to that in Example 2), 2.25 parts of collagen peptide, 0.75 part of vitamin C microcapsule, 3.5 parts of aloe gel extract, 0.35 part of dipotassium glycyrrhizinate, 3.5% of maltodextrin.

[0075] Preparation process:

[0076] Only mix honey, collagen peptide, vitamin C microcapsule, aloe gel extract, and dipotassium glycyrrhizinate.

[0077] Same low-temperature compounding, sterilization, and freeze-drying processes as in Example 2 (without the traditional Chinese medicine extraction step).

[0078] III. Experimental methods

[0079] 1. Animal model

[0080] Experimental subjects: 60 male SD rats (200 - 250 g), randomly divided into 4 groups (n = 15):

[0081] Normal control group: Raised normally, without modeling and intervention.

[0082] Model group: Myocardial ischemia model, without intervention.

[0083] Control group: Myocardial ischemia model + control medicated tea (dose 0.5 g / kg·d).

[0084] Example 2 group: Myocardial ischemia model + medicated tea of Example 2 (dose 0.5 g / kg·d).

[0085] 2. Establishment of myocardial ischemia model

[0086] Ligate the left anterior descending branch of the coronary artery (LAD) and maintain ischemia for 30 minutes.

[0087] 3. Administration plan

[0088] Continuous intragastric administration for 14 days after modeling.

[0089] 4. Detection indicators

[0090] Myocardial injury markers: Serum CK-MB (creatine kinase isoenzyme), LDH (lactate dehydrogenase).

[0091] Oxidative stress indicators: Serum SOD (superoxide dismutase), MDA (malondialdehyde).

[0092] Inflammatory factors: Serum TNF-α (tumor necrosis factor-α), IL-6 (interleukin-6).

[0093] Cardiac pathology: The degree of myocardial tissue lesions was observed by HE staining (scoring criteria: 0 - normal, 4 - severe necrosis).

[0094] IV. Experimental result comparison table

[0095]

[0096] V. Analysis of experimental results

[0097] Myocardial protection effect

[0098] The group of Example 2 significantly reduced the levels of CK - MB and LDH, indicating that it effectively alleviated myocardial cell injury, while the control group showed no significant improvement.

[0099] Cardiac pathology scores showed that the myocardial necrosis area in the group of Example 2 decreased by more than 60%, while that in the control group only decreased by 8%.

[0100] Antioxidant effect

[0101] The SOD activity in the group of Example 2 recovered to 87.5% of the normal level, and the MDA level decreased by 53%, which was significantly better than the control group.

[0102] Anti - inflammatory effect

[0103] In the group of Example 2, TNF - α and IL - 6 decreased by 64.7% and 62.5% respectively, while in the control group they only decreased by 5.9% and 4.2%, proving that the traditional Chinese medicine composition played a core role by inhibiting the inflammatory pathway.

[0104] VI. Conclusion

[0105] Our heart - protecting honey herbal tea (Example 2) significantly improved myocardial ischemia injury, inhibited oxidative stress and inflammatory responses through the synergistic effects of active ingredients of traditional Chinese medicine (such as tanshinone, notoginsenoside, astragalus polysaccharide, etc.). The control group, due to the lack of the heart - protecting traditional Chinese medicine composition and relying only on honey and beauty additives, had no significant heart - protecting effect. The experimental data fully verified the scientificity and clinical value of the formula of the present invention.

[0106] Example 5: Verifying that our heart - protecting honey herbal tea has beauty effects through experiments

[0107] I. Experimental purpose

[0108] To verify the differences in beauty effects in terms of antioxidant, moisturizing, promoting collagen synthesis and anti - inflammatory between our heart - protecting honey herbal tea (Example 2) and ordinary honey herbal tea (control group).

[0109] II. Preparation process of the control group

[0110] Control group formula:

[0111] Remove beauty active ingredients: free of collagen peptides, vitamin C microcapsules, aloe gel extract, dipotassium glycyrrhizinate.

[0112] Retain basic ingredients: honey (the same amount as in Example 2), maltodextrin 3.5% (only for freeze-drying and forming).

[0113] Preparation process:

[0114] Mix honey and purified water at a ratio of 1:5 and directly concentrate to the same volume as in Example 2.

[0115] Add maltodextrin and perform the same sterilization and freeze-drying process as in Example 2 (without the step of adding active ingredients).

[0116] III. Experimental methods

[0117] 1. Animal model

[0118] Experimental subjects: 40 female BALB / c mice (6 weeks old), randomly divided into 4 groups (n = 10): Normal control group: Normally raised without intervention.

[0119] UV damage group: Induce a skin photoaging model with ultraviolet rays (UVA / UVB) without intervention.

[0120] Control group: UV damage + control medicated tea (dose 1 g / kg·d, gavage).

[0121] Example 2 group: UV damage + medicated tea of Example 2 (dose 1 g / kg·d, gavage).

[0122] 2. Establishment of UV damage model

[0123] Perform daily UV irradiation (0.5 J / cm 2 UVA + 0.1 J / cm 2 UVB), continuously for 14 days.

[0124] 3. Drug administration plan

[0125] Start drug administration simultaneously with model establishment and continue for 28 days.

[0126] 4. Detection indicators

[0127] Skin barrier function: transepidermal water loss (TEWL), stratum corneum water content (Corneometer value). Antioxidant capacity: SOD activity and MDA content in skin tissue.

[0128] Collagen synthesis: hydroxyproline content (a collagen marker).

[0129] Inflammatory response: levels of IL-1β and MMP-1 (matrix metalloproteinase-1) in skin tissue.

[0130] IV. Comparative Table of Experimental Results

[0131]

[0132]

[0133] V. Analysis of Experimental Results

[0134] Skin Barrier Repair

[0135] In the second embodiment group, the TEWL decreased by 42.9% (only 10.7% in the control group), and the water content of the stratum corneum recovered to 84.4% of the normal level (only 56.8% in the control group), indicating that it significantly enhanced the moisturizing ability through collagen peptides and aloe extracts.

[0136] Antioxidation and Anti-photoaging

[0137] In the second embodiment group, the SOD activity increased by 87.5% and the MDA decreased by 53.8%, proving that vitamin C microcapsules and traditional Chinese medicine antioxidant components (such as wolfberry polysaccharide and astragalus flavonoids) synergistically scavenged free radicals.

[0138] Collagen Synthesis

[0139] In the second embodiment group, the hydroxyproline content was close to the normal level, while in the control group it only increased by 14.3%, showing that fish scale collagen peptides directly promoted collagen regeneration in the dermis.

[0140] Anti-inflammation and Anti-wrinkle

[0141] In the second embodiment group, IL-1β and MMP-1 decreased by 63.6% and 60% respectively, significantly inhibiting ultraviolet-induced inflammation and collagen degradation, while there was no statistical difference in the control group.

[0142] VI. Conclusion

[0143] Our heart-protecting honey medicinal tea (the second embodiment) significantly improved the skin barrier function, inhibited photoaging and inflammatory responses through the multi-target synergistic effects of collagen peptides, vitamin C microcapsules and traditional Chinese medicine compositions (such as aloe polysaccharide and dipotassium glycyrrhizinate).

[0144] Due to the lack of active ingredients, the control group only relied on the basic honey ingredients and could not achieve effective beauty effects. The data prove that the present invention has unique advantages in the field of oral beauty.

[0145] In the description of this specification, the description referring to terms such as "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0146] Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A unique preparation method of a heart-protecting honey medicinal tea, characterized in that, It includes the following steps: Step 1, raw material pretreatment: Mix the traditional Chinese medicine composition according to the mass ratio and crush it to a particle size ≤ 0.5 mm. The components of the traditional Chinese medicine composition are as follows by mass fraction: Salvia miltiorrhiza 5 - 10 parts, Hawthorn 8 - 15 parts, Notoginseng 3 - 6 parts, Astragalus membranaceus 5 - 10 parts, Cassia obtusifolia 4 - 8 parts, Rosa rugosa 4 - 5 parts, Poria cocos 6 - 12 parts, Lycium barbarum 4 - 10 parts, Angelica dahurica 2 - 5 parts; Step 2, segmented gradient extraction: The first stage: Mix the crushed traditional Chinese medicine composition with pure water according to the mass ratio of 1:10 - 15, carry out ultrasonic - assisted extraction at 40 - 50 °C, and simultaneously add β - cyclodextrin accounting for 0.1 - 0.3% of the total mass concentration to embed the volatile oil of Rosa rugosa. The conditions of the ultrasonic - assisted extraction are 25 - 40 kHz and 30 minutes; The second stage: Raise the temperature to 60 - 65 °C, add a composite enzyme and carry out constant - temperature enzymatic hydrolysis for 50 - 70 minutes. The composite enzyme includes 0.5% of cellulase and 0.3% of pectinase by the total mass; Step 3, low - temperature compounding and activity retention: Reduce the pressure of the extract to concentrate it to 1 / 4 of the original volume, and cool it to below 45 °C to obtain a concentrated solution; Add honey and beauty active additives. The beauty active additives are 1.5 - 3 parts of collagen peptide and 0.5 - 1 part of vitamin C microcapsule. The mass ratio of honey to the concentrated solution is 1:4 - 6, and stir - mix under nitrogen protection; Step 4, directional sterilization and stabilization: After ultra - high - pressure instantaneous sterilization, add 0.05 - 0.1% of natural preservative tea polyphenol by the total mass, and aseptically fill it into a freeze - dried granule dosage form. The conditions of the ultra - high - pressure instantaneous sterilization are 350 - 400 MPa and 3 minutes.

2. The unique preparation method of a heart-protecting honey herbal tea as claimed in claim 1, wherein, The traditional Chinese medicine composition further includes 2 - 5 parts of aloe gel extract and 0.2 - 0.5 part of dipotassium glycyrrhizinate.

3. The unique preparation method of a heart-protecting honey herbal tea as described in claim 1, characterized in that, In step 2, the operation of embedding the volatile oil of Rosa rugosa with β - cyclodextrin is carried out separately before ultrasonic extraction, the embedding temperature is 35 - 40 °C, and the embedding rate ≥ 85%.

4. The unique preparation method of a heart-protecting honey medicinal tea as claimed in claim 1, characterized in that, In step 3, the collagen peptide is a low - molecular - weight peptide derived from fish scales, and is added after being premixed with vitamin C microcapsule according to the mass ratio of 3:

1. The molecular weight of the low - molecular - weight peptide ≤ 1000 Da.

5. The unique preparation method of a heart-protecting honey medicinal tea as claimed in claim 1, wherein, When preparing the freeze - dried granule dosage form, add 2 - 5% of maltodextrin by the total liquid mass as a freeze - drying protectant. The freeze - drying procedure is: pre - freeze at - 40 °C for 2 hours, and carry out sublimation drying with a gradient temperature rise from - 20 °C to 0 °C. The water content of the final product ≤ 5%.

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