External application composition for promoting wound healing

Abstract

The invention discloses an external smearing composition for promoting wound healing, which is prepared from the following raw materials in percentage by weight: 0.005 to 0.1 percent of phytoextraction protease, 0.0001 to 0.0005 percent of nano-silver, 0.01 to 0.05 percent of chitosan, 0.03 to 0.05 percent of sodium hyaluronate, 0.30 to 0.40 percent of acid-base regulator, 1.0 to 5.0 percent of pawpaw extract, 7.0 to 13.0 percent of moisturizing regulator and the balance of solvent, the sum of the use amounts of the raw materials is 100 percent, and the moisturizing regulator is prepared from sea buckthorn fruit seed oil extract, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol, 1, 3-butanediol and 1, 3-butanediol. The composition is prepared from 1, 3-dihydroxybutane, an almond oil extract and a radix ophiopogonis root extract. The external application smearing composition for promoting wound healing is smeared on the skin surface, wound recovery can be accelerated, and the good skin care effect is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of skin-applied substances, and particularly relates to an external applied composition for promoting wound healing. Background Art

[0002] Traumatic wounds can be caused by various reasons, including but not limited to accidental injuries, surgeries, skin cancer treatments, etc. During the treatment of skin cancer, radiotherapy is a common treatment method. It uses high-energy rays to destroy cancer cells, thereby preventing their growth and spread. Radiotherapy may cause side effects such as skin redness, pain, dryness, peeling, etc., which are all normal reactions during the treatment process.

[0003] The harms of traumatic wounds mainly lie in: First, it is easy to become an invasion channel for bacteria and viruses, causing infections and even potentially more serious diseases; Second, it destroys the skin barrier function, making the body prone to losing water and electrolytes, increasing the risk of dehydration, etc.; Third, it may lead to long-term pain, bleeding, and the formation of scars, which will have a certain impact on an individual's quality of life and mental health.

[0004] Therefore, developing an external applied substance for promoting wound healing to accelerate the recovery of the wound has multiple benefits: First, it can significantly reduce the risk of infection because the faster the wound heals, the shorter the time it is exposed to the external environment; Second, accelerating the recovery can effectively relieve the pain and discomfort of the patient, thereby improving their quality of life; Third, a good healing process can reduce the formation of scars, helping to maintain the beauty and functional integrity of the skin; Finally, from an economic perspective, accelerating the recovery can also shorten the patient's treatment time, reduce medical costs, and help the patient return to normal work and life faster. Summary of the Invention

[0005] The purpose of the present invention is to provide an external applied composition for promoting wound healing. When applied to the skin surface, it can accelerate wound recovery and has good skin care effects.

[0006] To achieve the above purpose, the solution of the present invention is: An external applied composition for promoting wound healing, comprising raw materials in the following weight percentages: 0.005% - 0.1% plant extract protease, 0.0001% - 0.0005% nano silver, 0.01% - 0.05% chitosan, 0.03% - 0.05% sodium hyaluronate, 0.30% - 0.40% acid-base regulator, 1.0% - 5.0% papaya extract, 7.0% - 13.0% moisture regulator, and the balance of solvent. The sum of the amounts of the raw materials is 100%. The moisture regulator includes seabuckthorn fruit seed oil extract, 1,3-dihydroxybutane, almond oil extract, and ophiopogon japonicus root extract.

[0007] An externally applied smear composition for promoting wound healing, comprising raw materials in the following weight percentages: 0.04% plant extract protease, 0.0002% nano silver, 0.03% chitosan, 0.03% sodium hyaluronate, 0.3% acid-base regulator, 3.0% papaya extract, 3.0% seabuckthorn fruit seed oil extract, 1.0% 1,3-dihydroxybutane, 2.0% almond oil extract, 3.0% radix ophiopogonis extract, and 87.5998% solvent.

[0008] The solvent is deionized water, which is high-purity water obtained by removing dissolved inorganic ions (such as Ca 2+ , Mg 2+ , Na + , Cl - , SO4 2- etc.) in water through ion exchange or electrodeionization technology, and its resistivity can theoretically reach 18.2 MΩ·cm (25°C).

[0009] In the moisturizing regulator, the mass dosage ratio of seabuckthorn fruit seed oil extract, 1,3-dihydroxybutane, almond oil extract, and radix ophiopogonis extract is 3:1:2:3.

[0010] The acid-base regulator includes citric acid and sodium citrate with a mass dosage ratio of 2:1.

[0011] The healing and recovery of wounds require the combination of effects such as sterilization, growth factors that promote cell proliferation and repair, etc. The functions of the raw materials in an externally applied smear composition for promoting wound healing in the present invention are as follows: Plant extract protease plays an extremely important role in the process of promoting wound healing. Through its unique proteolytic ability, such enzyme substances can effectively remove necrotic tissue and foreign bodies in the wound area, thus creating a more ideal environment for the cleaning and healing of the wound, helping to reduce scar formation and improve the healing quality, so that the wound heals more quickly and thoroughly. In the process of promoting wound healing, protease can also promote the growth of new cells and the reconstruction of tissues. By decomposing necrotic tissue, they release growth factors that promote cell proliferation and repair, thus providing a good environment for the growth of new cells. This mechanism makes the wound healing process more efficient and also reduces the possible complications during the healing process; Due to its unique properties, silver exhibits excellent anti-infection effects. Tiny silver is prone to releasing silver ions, enabling the silver ions to quickly penetrate and pass through the bacterial cell wall, interfering with its normal functions, thereby achieving the purpose of inhibiting or killing bacteria; Chitosan is derived from natural polysaccharide substances. Its powerful antibacterial ability can effectively prevent wound infections, promote the rapid growth and differentiation of cells, thereby accelerating the wound healing rate. Chitosan can also keep the wound moist, providing an ideal recovery environment for the wound. In addition, its hemostatic properties and good biocompatibility also give it unique advantages in treating wounds; Sodium hyaluronate, which is a naturally occurring polysaccharide substance, can effectively promote the wound healing process, significantly reduce scar formation, and relieve the pain at the wound site through its moisturizing properties. In addition, sodium hyaluronate also has a certain anti-inflammatory effect, which can help reduce the risk of wound infection; As a natural extract, the efficacy of papaya extract is mainly reflected in the following aspects: ① Promote skin metabolism: The proteases contained in papaya, such as papain, can promote skin metabolism, making the skin smoother and more delicate; ② Repair damaged skin and antioxidant effect: Papaya is rich in vitamin C and antioxidant substances, which can help resist the damage of free radicals, slow down the process of skin aging, and these antioxidant components can help the skin resist the invasion of external environmental pollutants and reduce the damage of pollution to the skin; ③ The natural sugars and moisture in papaya can provide a moisturizing effect for the skin, help maintain the water balance of the skin, and prevent the skin from drying; ④ Certain components in papaya have an anti-inflammatory effect, which can reduce skin redness and inflammation, and have a soothing effect on sensitive skin; The acid-base regulator is used to adjust the pH value of the topical application composition; The moisturizing regulator is designed to provide moisture and moisturization to the skin, improve comfort and cool feeling, and relieve pain at the same time. It is composed of seabuckthorn fruit seed oil extract, 1,3-dihydroxybutane, almond oil extract and ophiopogon root extract. Seabuckthorn seed oil extract is rich in vitamins and bioactive substances, which helps nourish the skin, promote cell regeneration and repair. 1,3-dihydroxybutane is a polyol with water absorption and moisturizing and anti-inflammatory properties, suitable for various skin types. Almond oil extract is rich in vitamin E and has an antioxidant effect. Ophiopogon root extract contains moisturizing and anti-inflammatory components, which are beneficial to sensitive skin.

[0012] Taken together, silver can effectively sterilize, plant-derived proteases, chitosan and sodium hyaluronate can reduce the pain of wounds and promote the effect of cell self-repair. Combining the use of the moisturizing regulator can enhance skin comfort, reduce the pain of patients, and shorten the treatment cycle. Therefore, the topical application composition for promoting wound healing of the present invention, when applied to the skin surface, can accelerate wound recovery and has a good skin care effect. Description of the Drawings

[0013] Figures 1 to 5 It is a recovery process diagram of Application Example 1; Figure 6 Recovery process diagram for Application Example 2 Detailed implementation manners

[0014] To further explain the technical solution of the present invention, the present invention will be elaborated in detail below through specific embodiments.

[0015] I. Preparation of the topical application composition Examples 1 - 4 A topical application composition for promoting wound healing, comprising the following raw materials: plant extract protease, nano silver, chitosan, sodium hyaluronate, acid-base regulator, papaya extract, seabuckthorn fruit seed oil extract, 1,3-dihydroxybutane, almond oil extract, radix ophiopogonis extract, and solvent. The amounts of the raw materials in each example are shown in Table 1, and all raw materials are commercially available products.

[0016] Mix the above raw materials and stir evenly to obtain the topical application composition.

[0017] Table 1 Amounts of raw materials in each example

[0018] Explanation of the characteristics of the amounts of raw materials in each example: Example 1 (standard type) Applicable scenarios: ordinary trauma, postoperative incision.

[0019] Features: balanced formula, taking into account antibacterial, repair and moisturizing.

[0020] Key adjustment: 3.0% papaya extract promotes epidermal metabolism, and 0.03% chitosan provides basic antibacterial and moisturizing effects.

[0021] Example 2 (strong antibacterial type) Applicable scenarios: wounds with high infection risk (such as burns, chronic ulcers).

[0022] Features: enhanced antibacterial ability, quickly inhibiting bacterial proliferation.

[0023] Key adjustment: taking the upper limit value of nano silver (0.0005%) and chitosan (0.05%) to enhance the antibacterial barrier, and 0.40% acid-base regulator to optimize stability.

[0024] Example 3 (deep repair type) Applicable scenarios: deep wounds, scar prevention (such as large-area trauma, burns).

[0025] Features: enhanced repair.

[0026] Key adjustments: The high-concentration 5.0% papaya extract accelerates the decomposition of necrotic tissue. Chitosan (0.04%) and sodium hyaluronate (0.05%) synergistically promote collagen regeneration, and the 4.0% sea buckthorn fruit seed oil extract plays a role in strengthening repair.

[0027] Example 4 (for sensitive skin type) Applicable scenarios: Wounds of children or sensitive skin.

[0028] Features: Gentle formula.

[0029] Key adjustments: Adjust the dosage of plant-derived protease to 0.005%. The 5.0% sea buckthorn oil and 4.0% radix ophiopogonis provide anti-inflammatory and moisturizing effects, and the 3.0% almond oil enhances the soothing effect.

[0030] II. Application of the topical application composition Application Example 1 For a patient with giant cell tumor of bone undergoing surgery, after 25 times of local radiotherapy postoperatively, the skin ulcer could not heal. Treated with the topical application composition prepared in Example 1, during the medication period, it was directly applied to the wound surface after debridement, and the dosage per use was about 0.5 ml / cm 2 , and the recovery process was as Figures 1 to 5 shown. After 39 days of medication, the skin wound completely recovered and healed without scar.

[0031] Application Example 2 For the wound healing after a rhytidectomy, treated with the topical application composition prepared in Example 1, the medication method was to directly apply it to the wound surface, and the dosage per use was about 0.5 ml / cm 2 , and the preoperative and postoperative effects were as Figure 6 shown. The wound healed significantly well 24 hours after medication, and the wound scar was hardly visible on the 5th day after surgery. The wound could heal quickly, and at the same time, there was an effect of lightening the scar.

[0032] Verified through clinical trials, as in Application Examples 1 - 2, the topical application composition has a significant accelerating effect on the healing process of various traumas, burns, and surgical incisions, and can also achieve a good effect of lightening the scar for skin care.

[0033] The above embodiments and diagrams do not limit the product form and style of the present invention. Any appropriate changes or modifications made by those of ordinary skill in the art shall be regarded as not departing from the patent scope of the present invention.

Claims

1. An externally applied smear composition for promoting wound healing, characterized in that: It comprises raw materials in the following weight percentages: 0.005% - 0.1% plant - extracted protease, 0.0001% - 0.0005% nano - silver, 0.01% - 0.05% chitosan, 0.03% - 0.05% sodium hyaluronate, 0.30% - 0.40% acid - base regulator, 1.0% - 5.0% papaya extract, 7.0% - 13.0% moisture - retention regulator and the balance of solvent, the sum of the dosages of the raw materials being 100%, and the moisture - retention regulator includes seabuckthorn fruit seed oil extract, 1,3 - dihydroxybutane, almond oil extract and ophiopogon root extract.

2. The external application composition for promoting wound healing according to claim 1, wherein: It comprises raw materials in the following weight percentages: 0.04% plant - extracted protease, 0.0002% nano - silver, 0.03% chitosan, 0.03% sodium hyaluronate, 0.3% acid - base regulator, 3.0% papaya extract, 3.0% seabuckthorn fruit seed oil extract, 1.0% 1,3 - dihydroxybutane, 2.0% almond oil extract, 3.0% ophiopogon root extract and 87.5998% solvent.

3. The external application composition for promoting wound healing according to claim 1, characterized in that: The solvent is deionized water.

4. The topical application composition for promoting wound healing according to claim 1, wherein: In the moisture - retention regulator, the mass dosage ratio of seabuckthorn fruit seed oil extract, 1,3 - dihydroxybutane, almond oil extract and ophiopogon root extract is 3:1:2:

3.

5. The topical application composition for promoting wound healing according to claim 1, wherein: The acid - base regulator includes citric acid and sodium citrate with a mass dosage ratio of 2:1.

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