Total vein nutrition preparation method capable of avoiding dispensing errors

Abstract

The invention provides a total intravenous nutrition preparation method capable of avoiding dispensing errors, and relates to the technical field of intravenous nutrition preparation. A preparation device adopted by the method comprises a mixing cavity; an energy cavity; a waste liquid chamber; a tubular lumen; the energy cavity is arranged at the same end part of the mixing cavity, the waste liquid cavity and the tubular cavity; the tubular cavity is communicated with the energy cavity through a first fluid control component; the mixing cavity and the waste liquid cavity are both communicated with the energy cavity through a second fluid control component. The method provided by the invention can achieve accurate preparation of total vein nutrition, and the adopted preparation device is simple, convenient and sterile to operate, does not depend on an intravenous preparation center, can be operated in community hospitals and even families, and is convenient for patients.

Description

Technical Field

[0001] The present invention relates to the technical field of intravenous nutrition preparation, and particularly relates to a total parenteral nutrition preparation method that can avoid dispensing errors. Background Art

[0002] Total parenteral nutrition solution is beneficial to the utilization of various nutrients and reduces corresponding complications, and is an indispensable part of nutritional therapy. Preparing total parenteral nutrition solution is a highly complex and technically demanding operation. The preparation personnel need to undergo standardized training and assessment. Even so, due to the complex configuration process and many steps, operating errors often occur. For example: (1) Contamination: Even in the "intravenous admixture service center", if the preparation personnel do not thoroughly disinfect the surface of the laminar flow bench or the medicine bottle, or if the gloves are contaminated, etc., it may lead to bacterial or fungal contamination; (2) Preparation errors: More than 10 kinds of drugs are required to be mixed and prepared for total parenteral nutrition solution. Multiple syringes are used in the preparation process of electrolytes, trace elements, and vitamins. There are strict incompatibility taboos. There are also various requirements such as the principle of adding phosphorus first and then calcium, adding amino acids first and then sugar, and finally introducing fat emulsion when mixing drugs to avoid serious problems that endanger the safety of patients such as precipitation, discoloration, and fat emulsion demulsification. Operational errors such as incorrect addition of drugs, repeated addition, using the wrong syringe, and incorrect order when mixing drugs may occur due to long-term operation and fatigue of medical staff, resulting in serious mistakes such as incompatibility, incorrect dosage, calcium-phosphorus deposition, and fat emulsion stratification; (3) Physical foreign bodies: Improper opening of ampoules, and debris falling off due to repeated insertion and removal of the bottle stopper; (4) Adding drugs that should not be added due to incorrect doctor's orders: For example, vitamin C, antibiotics, etc. may cause precipitation or drug failure; (5) Inconvenient prescription verification: It is not easy to compare the finally prepared total parenteral nutrition solution with the prescription. (6) During long-term intense and large-scale work, there may also be cases where medical staff are pricked by needles during preparation.

[0003] In the prior art, the automated total parenteral nutrition preparation system uses a total parenteral solution mixer and dose scanning technology, which reduces manual intervention, but the price is very expensive, and most hospitals cannot purchase it; at the same time, although the total parenteral nutrition solution provided in the prior art (such as: "multi-chamber bag") simplifies the preparation process, it also has the following defects: (1) The formula has a fixed ratio and a single ratio, and cannot accurately adjust each nutritional component according to individual needs, especially electrolytes. Therefore, a large part of patients are not suitable for use. For example: because the formula contains potassium, patients with hyperkalemia cannot use it. (2) The "multi-chamber bag" does not contain essential components such as vitamins and trace elements, and different nutritional components need to be prepared again before use to meet the requirements of patients, which may pose a risk of contamination and increase the risk of phlebitis or catheter infection. Summary of the Invention In order to address the deficiencies in the background technology, the present invention provides a method for preparing total intravenous nutrition that can avoid medication errors. The method can achieve accurate preparation of total intravenous nutrition. The preparation device used is easy to operate and sterile, does not rely on an "intravenous preparation center", and can be operated in community hospitals or even at home, which is convenient for patients.

[0004] A total intravenous nutrition preparation method capable of avoiding medication errors, wherein the preparation device used in the method comprises: Mixing chamber; A waste liquid chamber, which is arranged side by side on one side of the mixing chamber; A tubular cavity, which is arranged side by side on a side of the waste liquid cavity away from the mixing cavity; An energy chamber, which is arranged at the same end of the mixing chamber, the waste liquid chamber and the tubular chamber; The tubular cavity is connected to the energy cavity through a first fluid control component; The mixing chamber and the waste liquid chamber are both connected to the energy chamber through the second fluid control component; wherein, when the second fluid control component is adjusted to connect the mixing chamber with the energy chamber, the waste liquid chamber is not connected to the energy chamber; when the second fluid control component is adjusted to connect the waste liquid chamber with the energy chamber, the mixing chamber is not connected to the energy chamber; The tubular cavity comprises a plurality of first tube bodies arranged side by side; the energy cavity comprises a plurality of second tube bodies arranged side by side; An infusion connection end is provided at one end of the mixing chamber away from the energy chamber; The preparation of total parenteral nutrition using a preparation device includes the following steps: After the energy chamber in the preparation device is arranged to be located at the top, the second fluid control component is adjusted according to the dosage of each nutrient in the total intravenous nutrition formula to discharge the excess liquid medicine in the energy chamber into the waste liquid chamber so that the remaining liquid medicine in the energy chamber is the dosage required by the prescription; Then, the energy chamber in the preparation device is arranged to be located at the bottom, and according to the dosage of each electrolyte, vitamin, and trace element nutrient in the total intravenous nutrition formula, the first fluid control component is adjusted to add the medicine in the tubular cavity into the corresponding energy chamber according to the prescription; After setting the energy chamber at the top in the preparation device, adjust each of the second fluid control components in order from left to right, so that the mixed medicine liquid with electrolytes, trace elements and vitamins added in the energy chamber is introduced into the mixing chamber in the set order, and the preparation is completed.

[0005] Preferably, one or more first tubes arranged in series and in parallel are each connected to one second tube.

[0006] Preferably, a first valve body is provided at each connection point between the first tube body and the second tube body.

[0007] Preferably, each of the first valve bodies includes a first valve housing and a first valve core; The first valve housing is horizontally disposed between the first pipe body and the second pipe body; The first valve core is disposed within the first valve housing and is sealingly connected to the inner wall of the first valve housing; one end of the first valve core extends outside the first valve housing and is provided with a first handle; First drain holes are symmetrically formed on both sides of the first valve housing; second drain holes communicating with the first drain holes are formed on both the first pipe body and the second pipe body; First exhaust holes are symmetrically formed on both sides of the first valve housing; second exhaust holes communicating with the first exhaust holes are formed on the second pipe body; Among them, the exhaust hole on the first valve housing close to the first pipe body is communicated with one end of the first pipe body far from the first valve housing through a first exhaust pipe; A through first through hole and a second through hole are formed on the first valve core; By rotating the first valve core with the first handle, both ends of the first through hole are communicated with the first drain holes on both sides, and at the same time, both ends of the second through hole are communicated with the first exhaust holes on both sides.

[0008] Preferably, each of the second pipe bodies is communicated with the mixing chamber and the waste liquid chamber through a second fluid control component.

[0009] Preferably, the second fluid control component includes a second valve housing and a second valve core; The second valve housing is disposed between the mixing chamber, the waste liquid chamber and the second pipe body, wherein a part of the second valve housing is located between the mixing chamber and the second pipe body, and another part is located between the waste liquid chamber and the second pipe body; The second valve core is disposed within the second valve housing and is sealingly connected to the inner wall of the second valve housing; One end of the second valve core extends to the second valve housing and is provided with a second handle; Third drain holes are symmetrically formed on both sides of the part of the second valve housing corresponding to the mixing chamber; fourth drain holes corresponding to and communicating with the third drain holes are formed on both the mixing chamber and the second pipe body; Fifth drain holes are symmetrically formed on both sides of the part of the second valve housing corresponding to the waste liquid chamber; sixth drain holes corresponding to and communicating with the fifth drain holes are formed on both the waste liquid chamber and the second pipe body; Third exhaust holes are symmetrically further formed on both sides of the part of the second valve housing corresponding to the mixing chamber; a fourth exhaust hole is formed on the mixing chamber, and the fourth exhaust hole is correspondingly communicated with the third exhaust hole on the corresponding side; On both sides of the second valve housing corresponding to the waste liquid chamber, fifth exhaust holes are symmetrically provided; on the waste liquid chamber, a sixth exhaust hole is provided, and the sixth exhaust hole is correspondingly communicated with the fifth exhaust hole on the corresponding side; The third exhaust hole on the other side and the fifth exhaust hole on the other side are both communicated with one end of the second pipe body far from the waste liquid chamber or the mixing chamber through a second exhaust pipe; On the second valve core, through third through holes, fourth through holes, fifth through holes and sixth through holes are provided; When the second valve core is rotated by the second handle, both ends of the third through hole are communicated with the third liquid discharge holes on both sides, and at the same time, both ends of the fourth through hole are communicated with the third exhaust holes on both sides; When the second valve core is rotated by the second handle, both ends of the fifth through hole are communicated with the fifth liquid discharge holes on both sides, and at the same time, both ends of the sixth through hole are communicated with the fifth exhaust holes on both sides.

[0010] Preferably, the axes of the third through hole and the fourth through hole are parallel and in the same plane; the axes of the fifth through hole and the sixth through hole are parallel and in the same plane; the axes of the third through hole and the fifth through hole are not in the same plane.

[0011] Preferably, one or more tearable isolation layers are provided in some of the first pipe bodies; The isolation layer includes a double-layer isolation film, and the double-layer isolation film is arranged in the first pipe body and divides the inner cavity of the first pipe body into two parts or multiple parts; A cross bar and a pull rod are clamped in the double-layer isolation film; one end of the pull rod is connected to the center of the cross bar, and the other end of the pull rod extends outside the first pipe body; An easy-to-tear line is provided on the double-layer isolation film; When the pull rod is dragged to drive the cross bar, the double-layer isolation film ruptures at the easy-to-tear line.

[0012] Preferably, scale lines are provided on each of the first pipe bodies and each of the second pipe bodies.

[0013] Preferably, a hook is provided at one end of the energy chamber far from the mixing chamber; the hook and the infusion connection end are arranged diagonally; the mixing chamber includes an infusion soft bag.

[0014] Compared with the prior art, the beneficial effects of the present invention: The present invention provides a total parenteral nutrition preparation method that can avoid dispensing errors. When preparing total parenteral nutrition solution by means of the device adopted in this method of the present invention, first, the redundant amino acids, sugars, and fat emulsions in the energy chamber are discharged into the waste liquid chamber by controlling the second fluid control component with reference to the scale on the energy chamber. Then, potassium, phosphorus, trace elements, high-concentration glucose, sodium, magnesium, calcium, and vitamins in the tubular chamber are respectively added to the second tube bodies of the corresponding energy chambers according to the scale; subsequently, the amino acids and sugars in the energy chamber that have been added with potassium, phosphorus, trace elements, high sugar, sodium, magnesium, and calcium are sequentially introduced into the mixing chamber for mixing, and then the fat emulsion of vitamins is introduced into the mixing chamber, thereby realizing the preparation of total parenteral nutrition solution.

[0015] The advantages of the present invention are as follows: (1) During the entire preparation process of the device, the drugs to be prepared are all the drugs already existing in the device, without contacting the outside world, and still maintain internal sterility. (2) Various drugs are stored separately and in fixed positions, and the "total parenteral nutrition treatment prescription" is prepared according to the set order. This "standardized preparation process" can avoid compatibility taboos such as wrong drug dispensing, precipitation, discoloration reaction, and fat emulsion breaking, and is simple to operate, suitable for grass-roots medical staff and even home operation. (3) It avoids the generation of impurities such as glass debris splashing and bottle stopper desquamation caused by repeated needle insertion during the preparation process. (4) External drugs cannot be added, avoiding the incorporation of drugs that do not meet the regulations such as vitamin C and antibiotics caused by wrong doctor's orders. (5) Even after the preparation is completed, the prescription can be reviewed through the remaining drugs. (6) The needleless design avoids needle stick injuries, and it is also an advantage that it greatly saves the physical strength of nurses. (7) The entire preparation process is carried out inside the device. The design of the air holes enables the reserved gas (high-purity sterile nitrogen) to circulate internally, and the setting of the waste liquid tank ensures that the excess liquid is discharged without contacting the outside world. It has low requirements for the preparation location and environment, and solves the needs of hospitals without "intravenous admixture service centers" such as communities and home parenteral nutrition treatment. (8) The electrolyte grid is slender, with precise scales, convenient switches, and air hole settings, enabling all nutritional components to be prepared as needed, and realizing individualized precision nutrition treatment. (9) The way of inverting the box body for preparation, combined with the setting of the switch, avoids the possibility of electrolyte leakage when not in use, and ensures the accuracy and safety of the preparation. Description of the Drawings

[0016] Figure 1 It is the rear structure diagram of the preparation device.

[0017] Figure 2 It is the front structure diagram of the preparation device.

[0018] Figure 3 It is the sectional view of the first valve body.

[0019] Figure 4 It is the structure diagram of the isolation layer.

[0020] Figure 5It is a sectional view of the second fluid control component.

[0021] Figure 6 It is a sectional view of the preparation device. Specific embodiments

[0022] The following describes several specific embodiments of the present invention in detail, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0023] The present invention provides a total parenteral nutrition preparation method that can avoid dispensing errors. All drugs, including electrolytes, vitamins, trace elements, sugars, amino acids, fat emulsions, etc., can be accurately adjusted and prepared according to individual needs. The positions of the drugs and the operation sequence are preset, and only by operating according to the set sequence can drug incompatibility be avoided, and the compatibility sequence also meets the requirements. The preparation process is simplified from complex to simple, avoiding dispensing errors. It does not need to rely on the "intravenous admixture service center" of the hospital, all drugs do not need to be added from the outside, the preparation process is sterile, and it is not restricted by the location environment.

[0024] To achieve the above object, refer to Figures 1 - 6 As shown, a total parenteral nutrition preparation method that can avoid dispensing errors. The preparation device used in this method includes a mixing chamber 27, a waste liquid chamber 29, a tubular chamber, and an energy chamber: The waste liquid chamber 29 is arranged side by side on one side of the mixing chamber 27; the tubular chamber is arranged side by side on the side of the waste liquid chamber 29 away from the mixing chamber 27; the energy chamber is arranged at the same end of the mixing chamber 27, the waste liquid chamber 29, and the tubular chamber; The tubular chamber is communicated with the energy chamber through a first fluid control component; the mixing chamber 27 and the waste liquid chamber 29 are both communicated with the energy chamber through a second fluid control component; Among them, when adjusting the second fluid control component to connect the mixing chamber with the energy chamber, the waste liquid chamber is not connected with the energy chamber; when adjusting the second fluid control component to connect the waste liquid chamber with the energy chamber, the mixing chamber is not connected with the energy chamber; The tubular chamber includes a plurality of first tube bodies arranged side by side; the energy chamber includes a plurality of second tube bodies arranged side by side; an infusion connection end is provided at one end of the mixing chamber away from the energy chamber; Using the preparation device for total parenteral nutrition preparation includes the following steps: After setting the energy chamber in the preparation device above, according to the doses of each nutrient in the total parenteral nutrition formula, adjust the second fluid control component to discharge the excess liquid medicine in the energy chamber into the waste liquid chamber, so that the remaining liquid medicine in the energy chamber is the dose required by the prescription; Subsequently, set the energy chamber in the preparation device to be located below, and according to the dosages of various electrolytes, vitamins, and trace elements in the total parenteral nutrition formula, adjust the first fluid control component to add the drugs in the tubular cavity into the corresponding energy chamber as required by the prescription. After setting the energy chamber in the preparation device to be located above, adjust each of the second fluid control components in the order from left to right, so that the mixed liquid medicine in the energy chamber that has been added with electrolytes, trace elements, and vitamins is introduced into the mixing chamber in the set order, and the preparation is completed.

[0025] Wherein, scale lines are provided on each of the first tubes and each of the second tubes.

[0026] It should be noted that drugs such as potassium, phosphorus, trace elements, high-concentration glucose, sodium, magnesium, calcium, and vitamins are pre-stored in the tubular cavity, and various drugs are separately stored in each first tube according to the set positions; the energy chamber is used to place energy substances such as amino acids, glucose, and fat emulsion. The vitamins are stored in the first tube provided with an isolation layer. The waste liquid chamber 29 is located in the interlayer between the mixing chamber and the tubular cavity.

[0027] When the preparation device provided in this embodiment is used to prepare total parenteral nutrition solution, first, according to the prescription and referring to the scale on the energy chamber, the excess amino acids, sugars, and fat emulsion in the energy chamber are discharged into the waste liquid chamber by controlling the second fluid control component. Then, according to the prescription and the scale, potassium, phosphorus, trace elements, high-concentration glucose, sodium, magnesium, calcium, and vitamins in the tubular cavity are respectively added into the corresponding second tubes; subsequently, the amino acids and sugars in the energy chamber that have been added with potassium, phosphorus, trace elements, high sugar, sodium, magnesium, and calcium are sequentially introduced into the mixing chamber in the order from left to right for mixing, and then the fat emulsion added with vitamins is introduced into the mixing chamber, thus realizing the preparation of total parenteral nutrition solution. During the whole preparation process, the device does not contact the outside world and still maintains internal sterility.

[0028] In order to accurately put the drugs in each first tube into the second tube, one or more continuously arranged and juxtaposed first tubes are all connected to one of the second tubes.

[0029] See Figure 1 As shown, the tubular cavity includes a plurality of first tubes arranged side by side. Among them, the plurality of first tubes arranged side by side successively include first tube 1, first tube 2, first tube 3, first tube 4, first tube 5, first tube 6, first tube 7, first tube 8, first tube 9, first tube 10, first tube 11, first tube 12, first tube 13, first tube 14, first tube 15, first tube 16, first tube 17, first tube 18.

[0030] The energy chamber includes a plurality of second tubes arranged side by side. Among them, the plurality of second tubes arranged side by side successively include second tube 19, second tube 20, second tube 21, second tube 22, second tube 23, and second tube 24; Among them, first tube 1, first tube 2, and first tube 3 are all connected to second tube 19; first tube 4, first tube 5, and first tube 6 are all connected to second tube 20; first tube 7, first tube 8, and first tube 9 are all connected to second tube 21; first tube 10, first tube 11, and first tube 12 are all connected to second tube 22; first tube 13, first tube 14, and first tube 15 are all connected to second tube 23; first tube 16, first tube 17, and first tube 18 are all connected to second tube 24.

[0031] During the use of the device, first tubes 1 to 15 are for accurately pre-storing drugs such as potassium, phosphorus, trace elements, high-concentration glucose, sodium, magnesium, calcium, etc. (the number can be adjusted), and various drugs are stored separately according to the set positions; First tubes 16 to 18 are tubular cavities for accurately pre-storing vitamins (the number can be adjusted), and their cavities are brown for light avoidance. To ensure accurate calibration, each first tube is slender, and according to different specifications, the recommended volumes are 5 ml, 10 ml, 20 ml, 30 ml, etc.

[0032] Second tubes 19 - 24 are for placing energy substances such as amino acids, glucose, and fat emulsion. Among them, the second tube for storing fat emulsion is set as second tube 24, which is located below the vitamin cavity. According to different specifications, the recommended volumes are 50 ml, 100 ml, 250 ml, 500 ml, etc. In this embodiment, a first valve body is provided at the connection between each of the first tubes and the second tubes.

[0033] Specifically, each of the first valve bodies includes a first valve housing and a first valve core; The first valve housing is horizontally arranged between the first tube and the second tube; The first valve core is arranged inside the first valve housing and is hermetically connected to the inner wall of the first valve housing; one end of the first valve core extends outside the first valve housing and is provided with a first handle 25; First drain holes are symmetrically opened on both sides of the first valve housing; second drain holes communicating with the first drain holes are opened on both the first tube and the second tube; among them, the drain hole on the first tube is second drain hole 36, and the drain hole on the second tube is second drain hole 38.

[0034] On both sides of the first valve housing, first exhaust holes are symmetrically formed; on the second pipe body, second exhaust holes communicating with the first exhaust holes are formed; among them, the exhaust holes on the second pipe body are the second exhaust holes 37, Among them, the first exhaust hole 35 on the first valve housing close to the first pipe body communicates with one end 33 of the first pipe body far from the first valve housing through a first exhaust pipe 34; A through first through hole 40 and a second through hole 39 are formed on the first valve core; By rotating the first valve core with a first handle, both ends of the first through hole are communicated with the first liquid discharge holes on both sides, and at the same time, both ends of the second through hole are communicated with the first exhaust holes on both sides.

[0035] It should be noted that the first valve housing can directly process the side walls of the first pipe body corresponding to the second pipe body into a valve body housing, so that the first pipe body and the second pipe body, and the first valve body between the first pipe body and the second pipe body form an integral body.

[0036] A liquid switch, that is, a first valve body, is provided between each of the first pipe bodies 1 to 18 and the corresponding second pipe body, with a total of 18 (the number can be adjusted according to the number of tubular cavities). Refer to Figure 3 As shown, when the first handle 25 is rotated counterclockwise to the right, the first through hole 40 is aligned with the liquid discharge holes 36 and 38 of the upper and lower cavities, and at the same time, the second through hole 39 is aligned with the exhaust holes 35 and 37 of the upper and lower cavities. At this time, the switch is in the open state. Due to the design of the exhaust hole 33 and the exhaust pipe 34, when the switch is opened, the air pressures in the upper and lower cavities are the same, avoiding poor liquid flow and inconsistent speeds in the tubular cavity; due to the action of gravity, the drug in the tubular cavity flows to the lower energy cavity. At this time, the flow rate can be adjusted by adjusting the angle of the rotary switch, and it can be accurately prepared according to the scale and the needs of the patient.

[0037] Among them, on the part of each second pipe body extending from the second liquid discharge hole 38 into the second pipe body, a liquid guide surface 41 is provided. Due to the provision of the liquid guide surface 41, the flowing liquid flows down along the liquid guide surface without affecting the air hole exhaust.

[0038] In this device, one or more tearable isolation layers are provided in some of the first pipe bodies; The isolation layer includes a double-layer isolation film 58, and the double-layer isolation film 58 is arranged in the first pipe body, dividing the inner cavity of the first pipe body into two parts or multiple parts; A cross bar 60 and a pull rod 59 are clamped inside the double-layer isolation film; one end of the pull rod 59 is connected to the center of the cross bar 60, and the other end of the pull rod extends outside the first pipe body to form a dragging end 32; An easy tear line 61 is provided on the double-layer isolation film; When dragging the pull rod 59 to drive the cross bar 60, the double-layer isolation film 58 ruptures at the tear line 61.

[0039] In this embodiment, the first tube bodies 16, 17, and 18 for storing vitamins are all provided with isolation layers; each first tube body for storing vitamins has one isolation layer switch, and the number of isolation layers can be adjusted according to the formulation requirements of vitamin types.

[0040] Its working principle is as Figure 4 shown. 58 is a double-layer isolation film, with a T-shaped pull rod 59 clamped inside. The front cross bar 60 of the T-shaped pull rod is tightly fixed in the sandwich layer of the double-layer isolation film. The tear line 61 is a pre-retained groove on the double-layer isolation film. When pulling out the drag end 32 outward, the double-layer isolation film ruptures at the tear line 61, and the medicine placed on the upper layer flows to the lower layer to dissolve or dilute the medicine stored in the lower layer. Among them, the drag end 32 cannot be pressed inward or in other directions to avoid accidental touch. Since the isolation layer is double-layer, when pulling out the switch, the medicine does not contact the outside world and still remains sterile inside.

[0041] In order to enable the mixing chamber 27 and the waste liquid chamber 29 to communicate with the energy chamber through the second fluid control component, each of the second tube bodies is provided to communicate with the mixing chamber 27 and the waste liquid chamber 29 through the second fluid control component.

[0042] Among them, the second fluid control component includes a second valve housing and a second valve core; it should be noted that the second fluid control component is also a valve body; The second valve housing is arranged between the mixing chamber 27, the waste liquid chamber 29 and the second tube body. Among them, a part of the second valve housing is located between the mixing chamber 27 and the second tube body, and another part is located between the waste liquid chamber 29 and the second tube body; The second valve core is arranged inside the second valve housing and is hermetically connected to the inner wall of the second valve housing; One end of the second valve core extends to the second valve housing and is provided with a second handle 26; The second valve housing is symmetrically provided with third drain holes on both sides corresponding to the part corresponding to the mixing chamber 27; fourth drain holes corresponding to and communicating with the third drain holes are opened on both the mixing chamber and the second tube body; the drain hole on the mixing chamber 27 is the fourth drain hole 48, and the drain hole on the second tube body is the fourth drain hole 44; The second valve housing is symmetrically provided with fifth drain holes on both sides corresponding to the part corresponding to the waste liquid chamber; sixth drain holes corresponding to and communicating with the fifth drain holes are opened on both the waste liquid chamber and the second tube body; the drain hole on the waste liquid chamber 29 is the sixth drain hole 49, and the drain hole on the second tube body is the sixth drain hole 45; On both sides of the second valve housing corresponding to the mixing chamber, third exhaust holes 43 are symmetrically provided; on the mixing chamber, a fourth exhaust hole is provided, and the fourth exhaust hole is correspondingly communicated with the third exhaust hole on the corresponding side; the exhaust hole on the mixing chamber 27 is the fourth exhaust hole 47; and the third exhaust hole on the other side is communicated with one end 42 of the second pipe body away from the mixing chamber through a second exhaust pipe 57; wherein, see Figure 5 As shown, the second exhaust pipe 57 is embedded in the side wall of the second pipe body. When the second exhaust pipe 57 is communicated with the third exhaust hole, a first passage 43 for communicating the third exhaust hole with the second exhaust pipe 57 is provided at the side wall of the second pipe body.

[0043] On both sides of the second valve housing corresponding to the waste liquid chamber, fifth exhaust holes 46 are symmetrically provided; on the waste liquid chamber, a sixth exhaust hole is provided, and the sixth exhaust hole is correspondingly communicated with the fifth exhaust hole on the corresponding side; the exhaust hole on the waste liquid chamber 29 is the sixth exhaust hole 50; and the fifth exhaust hole on the other side is communicated with one end 42 of the second pipe body away from the waste liquid chamber through the second exhaust pipe 57; see Figure 5 As shown, the second exhaust pipe 57 is embedded in the side wall of the second pipe body. When the second exhaust pipe 57 is communicated with the fifth exhaust hole, a second passage 46 for communicating the fifth exhaust hole with the second exhaust pipe 57 is provided at the side wall of the second pipe body.

[0044] The second valve core is provided with a through third through hole 52, a fourth through hole 51, a fifth through hole 54 and a sixth through hole 53. When the second valve core is rotated by the second handle 26, both ends of the third through hole 52 are communicated with the third liquid discharge holes on both sides, and at the same time, both ends of the fourth through hole 51 are communicated with the third exhaust holes on both sides. When the second valve core is rotated by the second handle 26, both ends of the fifth through hole 54 are communicated with the fifth liquid discharge holes on both sides, and at the same time, both ends of the sixth through hole 53 are communicated with the fifth exhaust holes on both sides.

[0045] In order to achieve that when adjusting the second fluid control component to communicate the mixing chamber with the energy chamber, the waste liquid chamber is not communicated with the energy chamber; when adjusting the second fluid control component to communicate the waste liquid chamber with the energy chamber, the mixing chamber is not communicated with the energy chamber; the axes of the third through hole and the fourth through hole are parallel and in the same plane; the axes of the fifth through hole and the sixth through hole are parallel and in the same plane; the axes of the third through hole and the fifth through hole are not in the same plane.

[0046] It should be noted that the second valve housing can directly use the side walls of the mixing chamber 27, the waste liquid chamber 29 corresponding to the second pipe body as the valve body housing.

[0047] Among them, a liquid guide surface 55 is provided on the part of the waste liquid cavity that extends from the sixth liquid discharge hole 49 into the waste liquid cavity; the mixing cavity 27 includes an infusion flexible bag 28.

[0048] Taking the second fluid control component as a fluid switch, with the second handle 26 as the handle of this fluid switch; each second pipe body corresponds to 1 switch, and there are a total of 6 switches in this embodiment; refer to Figure 5 As shown, the second handle can be rotated clockwise to the left and counterclockwise to the right respectively. When rotated clockwise to the left, the liquid discharge hole 54 and the exhaust hole 53 on the energy cavity switch are simultaneously aligned with the liquid discharge holes 45 and 49 and the exhaust holes 46 and 50 on the energy cavity and the waste liquid cavity. At this time, the channel between the energy cavity and the waste liquid cavity is opened, and the excess liquid in the energy cavity can be discharged along the liquid guide surface 55 to the waste liquid tank 29 in advance, leaving only the required amount of liquid. When the second handle is rotated counterclockwise to the right, the liquid discharge hole 52 and the exhaust hole 51 on the energy cavity switch are simultaneously aligned with the liquid discharge holes 44 and 48 and the exhaust holes 43 and 47 on the energy cavity and the mixing cavity. At this time, the channel between the energy cavity and the infusion flexible bag 28 in the mixing cavity is opened, and the liquid in the energy cavity can be discharged into the infusion flexible bag 28 in the mixing cavity. Similarly, due to the design of the exhaust hole 42 and the exhaust pipe 57, the air pressure is equal between the cavities after the switch is opened, and the liquid can flow at a uniform speed, which is conducive to precise adjustment. And due to the setting of the hole opening position on the switch and the limitation of the rotation angle of the switch, turning to the left can only open the switch between the energy cavity and the waste liquid cavity, and turning to the right can only open the switch between the energy cavity and the flexible bag in the mixing cavity.

[0049] Refer to Figure 2 As shown, the mixing cavity 27 includes an infusion flexible bag 28, specifically a large infusion flexible bag for total parenteral nutrition. The infusion flexible bag is connected to the energy cavity through a switch.

[0050] In this embodiment, a hook 30 is provided at one end of the energy cavity away from the mixing cavity; the hook 30 and the infusion connection end 62 are arranged diagonally.

[0051] Refer to Figure 1 As shown, 31 is the bottom plate switch of the mixing cavity. There is one on each side of the bottom plate. Press them inward together, and the bottom plate is detachable. When the mixing and preparation are completed, this switch can be opened, and the bottom plate can be removed. The hand can touch the flexible bag, and the terminal filter can be connected to the infusion connection end 62 for infusion.

[0052] To reduce the degradation of vitamins and lipid peroxidation during the preparation process, high-purity sterile nitrogen can be filled into the entire closed device to drive out oxygen and serve as internal circulating air.

[0053] In order to illustrate a total parenteral nutrition preparation method provided by the present invention that can avoid dispensing errors, the main preparation process includes: Pre-set each nutrient at a fixed position, where the position can be variable, there are no incompatibilities and it only needs to conform to the compatibility order. One example of the collocation method: The first tube bodies 1, 2: contain potassium chloride; the first tube body 3: contains sodium glycerophosphate; the first tube bodies 4, 5: are empty; the first tube body 6: contains trace elements; the first tube bodies 7, 8, 9: contain high-concentration glucose; the first tube bodies 10, 11: contain sodium chloride; the first tube body 12: contains magnesium sulfate; the first tube bodies 13, 14: are empty; the first tube body 15: contains calcium gluconate; the first tube bodies 16, 17: are empty; the first tube body 18 is separated by 1 isolation layer, and the upper and lower 2 layers respectively contain fat-soluble vitamins (liquid) and water-soluble vitamins; the second tube bodies 19, 20: contain amino acids; the second tube bodies 21, 22, 23: contain glucose; the second tube body 24: contains fat emulsion.

[0054] This kind of separate storage of electrolytes, vitamins, trace elements, etc. is equivalent to using different syringes for preparation during compounding. The fixed positions can ensure that potassium and phosphorus are added to the second tube body 19 of amino acids, trace elements are added to the second tube body 20 of amino acids, high-concentration glucose is added to the second tube body 21 of glucose, magnesium is added to the second tube body 22 of glucose, and calcium is added to the last second tube body 23 of glucose. That is, phosphorus, trace elements, magnesium, and calcium are respectively added to 4 different amino acid and glucose cavities, avoiding incompatibilities, and the order from left to right conforms to the order of importing into the infusion soft bag such as first phosphorus and then calcium, first amino acids and then sugar; at the same time, it also ensures that only multiple vitamins for injection are added to the fat emulsion, and the positions from left to right conform to the regulation that the fat emulsion is finally mixed and enters the infusion soft bag.

[0055] When using a compounding device to compound total parenteral nutrition solution, operate according to the following steps: S1. First, place the compounding box as Figure 2 placed, and turn on the switches of the second tube bodies 19 - 24 in a clockwise rotation from left to right in sequence. According to the doses of each nutrient on the individualized total parenteral nutrition prescription and referring to the scales on the second tube bodies, drain the excess amino acids, sugar, and fat emulsion in the second tube bodies into the waste liquid cavity, and then turn off the switches. At this time, the remaining amino acids, sugar, and fat emulsion are all the doses required on the prescription.

[0056] S2. Then, place the compounding box as Figure 1 placed, and turn on the switches of the first tube bodies 1 - 15 in a counterclockwise rotation from left to right in sequence (except for the empty cavities). According to the doses required on the individualized total parenteral nutrition prescription and by the scales, add potassium, phosphorus, trace elements, high-concentration glucose, sodium, magnesium, and calcium to the corresponding second tube bodies respectively, and then turn off the switches.

[0057] S3. Gently pull out the switch of the isolation layer on the vitamin tubular cavity. The double-layer isolation film ruptures at 61, and the fat-soluble vitamins flow to the lower layer, dissolving the water-soluble vitamins. Shake well, then turn the switch of the first tube body 18 counterclockwise to the right to open it. According to the required dose on the individualized total parenteral nutrition prescription, add it to the fat emulsion according to the scale. At this time, all the nutritional components in the formula have been added to each second tube body as required.

[0058] S4. Then place the preparation box as Figure 2 placed, and turn the switches of the second tube bodies 19 - 23 counterclockwise to the right in sequence from left to right to open them. First, introduce the amino acids, sugars with potassium, phosphorus, trace elements, high sugar, sodium, magnesium, and calcium added in the second tube bodies into the infusion soft bag in the mixing cavity in sequence, and then close the switches of the second tube bodies.

[0059] S5. After shaking well and ensuring there is no precipitation and color change, turn the switch of the second tube body 24 to open it, and slowly introduce the fat emulsion with added vitamins into the infusion soft bag in the mixing cavity. While introducing the fat emulsion, gently shake it well. After completion, close the switch, and the preparation is completed.

[0060] S6. Observe for half an hour. If the mixed solution has no stratification, no color change, and no precipitation, the bottom plate of the mixing cavity can be opened, and the infusion connection end (infusion plug) 62 is connected to the terminal filter for infusion.

[0061] This device can have several different sizes and capacities, and is applicable to people from infants to adults.

[0062] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and its equivalent technologies, the present invention is also intended to include these changes and modifications.

Claims

1. A total parenteral nutrition preparation method that can avoid dispensing errors, characterized in that, The dispensing device adopted by this method includes: A mixing chamber; A waste liquid chamber, which is arranged side by side on one side of the mixing chamber; A tubular chamber, which is arranged side by side on the side of the waste liquid chamber away from the mixing chamber; An energy chamber, which is arranged at the same end of the mixing chamber, the waste liquid chamber and the tubular chamber; The tubular chamber and the energy chamber are connected through a first fluid control component; The mixing chamber and the waste liquid chamber are both connected to the energy chamber through a second fluid control component; wherein, when adjusting the second fluid control component to connect the mixing chamber with the energy chamber, the waste liquid chamber is not connected to the energy chamber; when adjusting the second fluid control component to connect the waste liquid chamber with the energy chamber, the mixing chamber is not connected to the energy chamber; The tubular chamber includes a plurality of first pipe bodies arranged side by side; the energy chamber includes a plurality of second pipe bodies arranged side by side; An infusion connection end is arranged at one end of the mixing chamber away from the energy chamber; Using the dispensing device for total parenteral nutrition preparation, includes the following steps: After setting the energy chamber in the dispensing device above, according to the doses of each nutrient in the total parenteral nutrition formula, adjust the second fluid control component to discharge the excess liquid medicine in the energy chamber into the waste liquid chamber, so that the remaining liquid medicine in the energy chamber is the dose required by the prescription; Subsequently, set the energy chamber in the dispensing device below, and according to the doses of each electrolyte, vitamin, and trace element in the total parenteral nutrition formula, adjust the first fluid control component to add the medicines in the tubular chamber into the corresponding energy chamber as required by the prescription; Then set the energy chamber in the dispensing device above, and adjust each of the second fluid control components in order from left to right, so that the mixed liquid medicine with added electrolytes, trace elements and vitamins in the energy chamber is introduced into the mixing chamber in the set order, and the preparation is completed.

2. The total parenteral nutrition preparation method for avoiding dispensing errors according to claim 1, wherein One or more consecutive and juxtaposed first pipe bodies are all connected to one of the second pipe bodies.

3. The total parenteral nutrition preparation method for avoiding dispensing errors according to claim 2, characterized in that, A first valve body is arranged at the connection of each first pipe body and the second pipe body.

4. The total parenteral nutrition preparation method capable of avoiding dispensing errors according to claim 3, characterized in that, Each first valve body includes a first valve housing and a first valve core; The first valve housing is horizontally arranged between the first pipe body and the second pipe body; The first valve core is arranged in the first valve housing and is hermetically connected to the inner wall of the first valve housing; one end of the first valve core extends outside the first valve housing and is provided with a first handle; First drain holes are symmetrically opened on both sides of the first valve housing; second drain holes communicating with the first drain holes are opened on both the first pipe body and the second pipe body; First exhaust holes are symmetrically opened on both sides of the first valve housing; a second exhaust hole communicating with the first exhaust hole is opened on the second pipe body; Wherein, the exhaust hole on the first valve housing close to the first pipe body is connected to the end of the first pipe body away from the first valve housing through a first exhaust pipe; A through first through hole and a second through hole are opened on the first valve core; By rotating the first valve core through the first handle, the two ends of the first through hole are communicated with the first drain holes on both sides, and at the same time, the two ends of the second through hole are communicated with the first exhaust holes on both sides.

5. The total parenteral nutrition preparation method capable of avoiding dispensing errors according to claim 1, characterized in that, Each second pipe body is connected to the mixing chamber and the waste liquid chamber through a second fluid control component.

6. The total parenteral nutrition preparation method for avoiding dispensing errors according to claim 5, characterized in that, The second fluid control component includes a second valve housing and a second valve core; The second valve housing is arranged between the mixing chamber, the waste liquid chamber and the second tube body. Among them, a part of the second valve housing is located between the mixing chamber and the second tube body, and the other part is located between the waste liquid chamber and the second tube body; The second valve core is arranged inside the second valve housing and is hermetically connected to the inner wall of the second valve housing; One end of the second valve core extends to the second valve housing and is provided with a second handle; On both sides of the part of the second valve housing corresponding to the mixing chamber, third liquid discharge holes are symmetrically opened; on both the mixing chamber and the second tube body, fourth liquid discharge holes corresponding to and communicating with the third liquid discharge holes are opened; On both sides of the part of the second valve housing corresponding to the waste liquid chamber, fifth liquid discharge holes are symmetrically opened; on both the waste liquid chamber and the second tube body, sixth liquid discharge holes corresponding to and communicating with the fifth liquid discharge holes are opened; On both sides of the part of the second valve housing corresponding to the mixing chamber, third exhaust holes are symmetrically further opened; on the mixing chamber, a fourth exhaust hole is opened, and the fourth exhaust hole is correspondingly communicated with the third exhaust hole on the corresponding side; On both sides of the part of the second valve housing corresponding to the waste liquid chamber, fifth exhaust holes are symmetrically further opened; on the waste liquid chamber, a sixth exhaust hole is opened, and the sixth exhaust hole is correspondingly communicated with the fifth exhaust hole on the corresponding side; The third exhaust hole on the other side and the fifth exhaust hole on the other side are both communicated with one end of the second tube body far from the waste liquid chamber or the mixing chamber through a second exhaust pipe; A through third through hole, a fourth through hole, a fifth through hole and a sixth through hole are opened on the second valve core; When the second valve core is rotated by the second handle, both ends of the third through hole are communicated with the third liquid discharge holes on both sides. At the same time, both ends of the fourth through hole are communicated with the third exhaust holes on both sides; When the second valve core is rotated by the second handle, both ends of the fifth through hole are communicated with the fifth liquid discharge holes on both sides. At the same time, both ends of the sixth through hole are communicated with the fifth exhaust holes on both sides.

7. The total parenteral nutrition preparation method for avoiding dispensing errors according to claim 6, characterized in that, The axes of the third through hole and the fourth through hole are parallel and in the same plane; the axes of the fifth through hole and the sixth through hole are parallel and in the same plane; the axes of the third through hole and the fifth through hole are not in the same plane.

8. The total parenteral nutrition preparation method for avoiding dispensing errors according to claim 1, characterized in that, One or more tearable isolation layers are arranged in a part of the first tube bodies; The isolation layer includes a double-layer isolation film, and the double-layer isolation film is arranged inside the first tube body, dividing the inner cavity of the first tube body into two parts or multiple parts; A cross bar and a pull rod are clamped inside the double-layer isolation film; one end of the pull rod is connected to the center of the cross bar, and the other end of the pull rod extends outside the first tube body; An easy tear line is arranged on the double-layer isolation film; When the pull rod is dragged to drive the cross bar, the double-layer isolation film ruptures at the easy tear line.

9. The total parenteral nutrition preparation method capable of avoiding dispensing errors according to claim 1, characterized in that, Scale lines are arranged on each of the first tube bodies and each of the second tube bodies.

10. The total parenteral nutrition preparation method capable of avoiding dispensing errors according to claim 1, characterized in that, A hook is arranged at one end of the energy cavity far from the mixing chamber; the hook and the infusion connection end are arranged diagonally; the mixing chamber includes an infusion soft bag.

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