Full-automatic chemiluminescence immunoassay analyzer

Abstract

The invention belongs to the technical field of medical detection equipment, and provides a full-automatic chemiluminescence immunoassay analyzer which comprises a sampling device and a sample introduction device, the sample introduction device comprises a rack, the rack is provided with a detection channel and an urgent channel, the detection channel and the urgent channel are each internally provided with a first conveying structure used for conveying samples, and the first conveying structures are arranged on the rack; the sampling devices are arranged above the detection channel, the number of the sampling devices is m, the m sampling devices are sequentially arranged at intervals in the length direction of the detection channel, and m is larger than or equal to 2; and the transfer assemblies are arranged below the sampling devices, the transfer assemblies are in one-to-one correspondence with the sampling devices, and the transfer assemblies are used for transferring the detected samples in the urgent channel into the detection channel and synchronously moving the samples at the sampling stations out of the detection channel. The full-automatic chemiluminescence immunoassay analyzer provided by the invention is simple in structure, reasonable in design and relatively high in treatment efficiency on an urgent sample.

Description

Technical Field

[0001] The present invention relates to the technical field of medical testing equipment, and particularly to a fully automatic chemiluminescence immunoassay analyzer. Background Art

[0002] Chemiluminescence immunoassay (CLIA for short) is a detection and analysis technology that combines highly sensitive chemiluminescence determination technology with highly specific immune reactions and is used for the detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs, etc. It is the latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluorescence immunoassay, and time-resolved fluorescence immunoassay.

[0003] To avoid the influence of uncertain factors such as cumbersome traditional biomedical testing operations, long sample turnover cycles, and human interference, a fully automatic chemiluminescence immunoassay analyzer has emerged. And the sampling device, as an indispensable part of the fully automatic chemiluminescence immunoassay analyzer, plays an important role in the working efficiency of the entire analyzer.

[0004] However, the sampling device of the fully automatic chemiluminescence immunoassay analyzer in the prior art has only a single channel, resulting in sequential detection during the detection process. When there is an emergency patient who needs to be tested urgently, it still needs to wait until the previous patient's test is completed before it can be tested, seriously delaying the detection time of such patients and thus delaying the condition of such patients. Summary of the Invention

[0005] Aiming at the defects in the prior art, the purpose of the present invention is to provide a fully automatic chemiluminescence immunoassay analyzer to solve or alleviate one or more of the above-mentioned technical problems and other aspects in the prior art.

[0006] To achieve the above purpose, the present invention provides a fully automatic chemiluminescence immunoassay analyzer, including a sampling device and a sampling device. The sampling device includes:

[0007] A frame provided with a detection channel and an emergency channel. A first conveying structure for conveying samples is provided in both the detection channel and the emergency channel. The sampling device is arranged above the detection channel. There are m sampling devices, and the m sampling devices are arranged at intervals in sequence along the length direction of the detection channel, where m≥2; and

[0008] A transfer component, which is arranged below the sampling device. The transfer components correspond to the sampling devices one by one. The transfer component is used to transfer the detected sample in the urgent channel to the detection channel and synchronously move the sample at the sampling station out of the detection channel.

[0009] Further, n first conveying structures are arranged in both the detection channel and the urgent channel, where n = m + 1, and the n first conveying structures and the m transfer components are alternately arranged in sequence. The first conveying structure includes:

[0010] First conveying rollers, which are rotatably connected to the frame. There are two first conveying rollers, and the two first conveying rollers are arranged at intervals along the length direction of the frame and are rotatably connected to the frame;

[0011] First conveyor belts, which are sleeved outside the two first conveying rollers and can rotate with the rotation of the conveying rollers; and

[0012] First motors, which are fixedly arranged on the frame, and the power output shaft of the first motor is in transmission connection with the power input shaft of any one of the two first conveying rollers.

[0013] Further, the transfer component includes:

[0014] Sliders, which are provided with at least three conveying channels, and the sliders have a first position and a second position that can be switched with each other. When the slider is in the first position or the second position, there is one conveying channel corresponding to the detection channel and the urgent channel respectively;

[0015] Second conveying structures, which correspond to the conveying channels one by one, and the second conveying structures are arranged on the sliders; and

[0016] Third driving structures, which are arranged on the frame, and the third driving structures are used to drive the sliders to move from the first position to the second position or from the second position to the first position.

[0017] Further, there are four conveying channels, and the slider has a first position, a second position and a third position that can be switched with each other. Among them, when the slider is in the first position, the second position or the third position, there is one conveying channel corresponding to the urgent channel and the detection channel respectively. When the slider is in the first position, the two middle conveying channels correspond to the detection channel and the urgent channel respectively. The third driving structure is used to drive the slider from the first position to the second position, from the second position to the first position, from the first position to the third position or from the third position to the first position.

[0018] Further, the second conveying structure includes:

[0019] Second conveying rollers, which are arranged on the slider and rotatably connected to the slider. There are two second conveying rollers, and the two second conveying rollers are arranged at intervals in sequence along the length direction of the conveying channel;

[0020] A second conveyor belt, which is sleeved outside the two second conveying rollers and can rotate with the rotation of the second conveying rollers; and

[0021] A second motor, which is fixedly arranged on the slider, and the power output shaft of the second motor is in transmission connection with the power input shaft of any one of the two second conveying rollers.

[0022] Further, the third driving structure includes:

[0023] A third lead screw, which is rotatably connected to the frame;

[0024] A third nut, which is sleeved on the third lead screw. When the third lead screw is rotated, the third nut can move along the axial line direction of the third lead screw, and the third nut is fixedly connected to the slider; and

[0025] A third motor, which is fixedly arranged on the frame, and the power output shaft of the third motor is in transmission connection with the third lead screw.

[0026] Advantages of the present invention:

[0027] The full-automatic chemiluminescence immunoassay analyzer provided by the present invention enables the urgent samples in the urgent channel to be sampled and detected without waiting for the routine samples to be sampled completely by setting an urgent channel, a detection channel and a transfer component, thereby improving the detection efficiency of the urgent samples. Description of the Drawings

[0028] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the specific embodiments or the prior art. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to actual scale.

[0029] Figure 1 It is a perspective view of the full-automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present invention;

[0030] Figure 2 For Figure 1 The enlarged view of part A shown;

[0031] Figure 3 is Figure 1 an enlarged view of part B shown in the figure;

[0032] Figure 4 is Figure 1 a sectional view of the fully automatic chemiluminescence immunoassay analyzer shown in the figure;

[0033] Figure 5 is Figure 1 a top view of the fully automatic chemiluminescence immunoassay analyzer shown in the figure;

[0034] Figure 6 is Figure 5 an enlarged view of part C shown in the figure;

[0035] Figure 7 is Figure 1 a perspective view of the first conveying structure of the fully automatic chemiluminescence immunoassay analyzer shown in the figure.

[0036] Reference numerals:

[0037] 100, frame; 110, urgent channel; 120, detection channel; 210, slider; 211, conveying channel; 221, second conveying roller; 222, second conveyor belt; 223, second motor; 231, third lead screw; 232, third nut; 233, third motor; 310, first conveying roller; 320, first conveyor belt; 330, first motor. Detailed implementation manners

[0038] Hereinafter, embodiments of the technical solutions of the present invention will be described in detail with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solutions of the present invention, so they are only examples and cannot be used to limit the protection scope of the present invention.

[0039] It should be noted that unless otherwise specified, the technical terms or scientific terms used in this application should have the ordinary meaning understood by those skilled in the art to which the present invention belongs.

[0040] In the description of this application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0041] In addition, terms such as "first", "second", etc. are only used for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. In the description of the present invention, "a plurality of" means more than two unless otherwise specifically defined.

[0042] In this application, unless otherwise clearly specified and defined, terms such as "installed", "connected", "connected to", "fixed", etc. should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0043] In this application, unless otherwise clearly specified and defined, the first feature being "on" or "under" the second feature can be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature can be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" and "underneath" the second feature can be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0044] As Figure 1-7 shown, the present invention provides a fully automatic chemiluminescence immunoassay analyzer, which includes a sampling device (not shown in the drawings) and a sample injection device. The sample injection device includes a frame 100 and a transfer assembly.

[0045] The frame 100 is provided with a detection channel 120 and an emergency channel 110, and a first conveying structure for conveying samples is provided in both the detection channel 120 and the emergency channel 110. The sampling device is arranged above the detection channel 120, so that the sampling station corresponds to the detection channel 120. There are m sampling devices, and the m sampling devices are arranged at intervals in sequence along the length direction of the detection channel 120, where m≥2. Correspondingly, there are m sampling stations.

[0046] The transfer assembly is arranged below the sampling device, so that the sampling station corresponds to the transfer assembly. The transfer assembly corresponds to the sampling device one by one, and the transfer assembly is used to transfer the detected sample in the emergency channel 110 into the detection channel 120 and synchronously remove the sample at the sampling station from the detection channel 120.

[0047] During operation, after the urgent samples in the urgent channel 110 are transported to the transfer component, the transfer component transports the samples into the detection channel 120, where they are sampled by the sampling device for detection. During this process, if there is a sample at the sampling station, the transfer component removes the sample from the detection channel 120, so that there is no need to wait until the sample is sampled before sampling and detecting the urgent samples, greatly improving the detection efficiency of the urgent samples.

[0048] As Figure 1-7 shown, in this embodiment, n first conveying structures are provided in both the detection channel 120 and the urgent channel 110, where n = m + 1, and the n first conveying structures and the m transfer components are alternately arranged in sequence. The first conveying structure includes a first conveying roller 310, a first conveyor belt 320, and a first motor 330.

[0049] Among them, the first conveying roller 310 is rotatably connected to the frame 100. There are two first conveying rollers 310, and the two first conveying rollers 310 are spaced along the length direction of the frame 100 and rotatably connected to the frame 100. The first conveyor belt 320 is sleeved outside the two first conveying rollers 310 and can rotate with the rotation of the conveying roller. The first motor 330 is fixedly arranged on the frame 100, and the power output shaft of the first motor 330 is in transmission connection with the power input shaft of any one of the two first conveying rollers 310 to drive the first conveying roller 310 to rotate.

[0050] During operation, the first motor 330 drives the first conveying roller 310 to rotate, thereby driving the first conveyor belt 320 to rotate, and further achieving the purpose of transporting the samples.

[0051] The first conveying structure provided in this embodiment has a simple structure and a reasonable design.

[0052] Preferably, the first motor 330 is a servo motor.

[0053] As Figure 1-7 shown, the transfer component includes a slider 210, a second conveying structure, and a third driving structure.

[0054] The slider 210 is provided with at least three conveying channels 211, and the slider 210 has a first position and a second position that can be switched with each other. When the slider 210 is in the first position or the second position, two conveying channels 211 respectively correspond to the detection channel 120 and the urgent channel 110. The second conveying structure corresponds to the conveying channel 211 one by one, and the second conveying structure is arranged on the slider 210. The third driving structure is arranged on the frame 100, and the third driving structure is used to drive the slider 210 to move from the first position to the second position or from the second position to the first position.

[0055] During use, the first conveying structure in the urgent channel 110 or the detection channel 120 conveys the corresponding sample to the corresponding conveying channel 211, and the third driving structure first conveys the sample entering the conveying channel 211 to the position corresponding to the sampling station for sampling.

[0056] When the urgent sample in the urgent channel 110 is conveyed to the corresponding conveying channel 211 and the third driving structure first conveys the sample entering the conveying channel 211 to the position corresponding to the sampling station, the third driving structure drives the slider 210 from the first position to the second position, thereby transferring the urgent sample in the urgent channel 110 to the sampling station for sampling by the sampling device. After sampling is completed, when the third driving structure drives the slider 210 from the second position to the first position, the slider 210 is restored to its initial position.

[0057] As Figure 1-7 shown, there are four conveying channels 211, and the slider 210 has a first position, a second position, and a third position that can be switched with each other. Among them, when the slider 210 is in the first position, the second position, or the third position, there is a corresponding conveying channel 211 for both the urgent channel 110 and the detection channel 120. And when the slider 210 is in the first position, the two middle conveying channels 211 correspond to the detection channel 120 and the urgent channel 110 respectively. The third driving structure is used to drive the slider 210 from the first position to the second position, from the second position to the first position, from the first position to the third position, or from the third position to the first position.

[0058] During operation, under normal working conditions, the slider 210 is in the first position. When the urgent sample in the urgent channel 110 is conveyed onto the slider 210, the third driving structure drives the slider 210 from the first position to the second position, thereby transferring the urgent sample in the urgent channel 110 to the sampling station for sampling by the sampling device. After sampling is completed, when the third driving structure drives the slider 210 from the second position to the first position, the slider 210 is restored to its initial position.

[0059] When the sample in the detection channel 120 is converted from the normal state to the urgent state and needs to be sampled by the rear sampling device, after the sample moves onto the slider 210, the third driving structure drives the slider 210 from the first position to the third position, thereby transferring the sample in the detection channel 120 to the urgent channel 110. The urgent channel 110 conveys it to the corresponding sampling station for sampling and detection. After that, when the third driving structure drives the slider 210 from the third position to the first position, the slider 210 is restored to its initial position.

[0060] In this embodiment, it is possible to perform urgent detection on the samples in the urgent channel 110. At the same time, it is also possible to transfer the regular samples in the detection channel 120 to the urgent channel 110 for urgent detection.

[0061] The transfer component provided in this embodiment has a simple structure and a reasonable design.

[0062] As Figure 1-7 shown, the second conveying structure includes a second conveying roller 221, a second conveyor belt 222, and a second motor 223.

[0063] The second conveying roller 221 is arranged on the slider 210 and is rotatably connected to the slider 210. There are two second conveying rollers 221, and the two second conveying rollers 221 are arranged at intervals in sequence along the length direction of the conveying channel 211. The second conveyor belt 222 is sleeved outside the two second conveying rollers 221 and can rotate with the rotation of the second conveying rollers 221. The second motor 223 is fixedly arranged on the slider 210, and the power output shaft of the second motor 223 is in transmission connection with the power input shaft of any one of the two second conveying rollers 221.

[0064] During operation, the second motor 223 drives the second conveying roller 221 to rotate, thereby driving the second conveyor belt 222 to rotate, and further achieving the purpose of conveying the samples.

[0065] The second conveying structure provided in this embodiment has a simple structure and a reasonable design.

[0066] Preferably, the second motor 223 is a servo motor.

[0067] As Figure 1-7 shown, the third driving structure includes a third lead screw 231, a third nut 232, and a third motor 233.

[0068] The third lead screw 231 is rotatably connected to the frame 100. The third nut 232 is sleeved on the third lead screw 231, and when the third lead screw 231 rotates, the third nut 232 can move along the axis direction of the third lead screw 231. The third nut 232 is fixedly connected to the slider 210. The third motor 233 is fixedly arranged on the frame 100, and the power output shaft of the third motor 233 is in transmission connection with the third lead screw 231.

[0069] When in use, the third motor 233 drives the third lead screw 231 to rotate to drive the nut to move, so as to drive the slider 210 from the first position to the second position, from the second position to the first position, from the first position to the third position, or from the third position to the first position through the nut.

[0070] The third driving structure provided in this embodiment has a simple structure and a reasonable design.

[0071] Preferably, the third motor 233 is a servo motor.

[0072] In the description of the present invention, a large number of specific details are set forth. However, it can be understood that embodiments of the present invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail so as not to obscure the understanding of this description.

[0073] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered by the scope of the claims and the description of the present invention.

Claims

1. An automatic chemiluminescence immunoassay analyzer, comprising a sampling device and a sample injection device, characterized in that, The sample injection device includes: a frame provided with a detection channel and an urgent channel. A first conveying structure for conveying samples is arranged in both the detection channel and the urgent channel. The sampling device is arranged above the detection channel. There are m sampling devices, and the m sampling devices are arranged at intervals in the length direction of the detection channel, where m≥2; and a transfer assembly arranged below the sampling device. The transfer assembly corresponds to the sampling device one by one. The transfer assembly is used to transfer the detected sample in the urgent channel into the detection channel and synchronously remove the sample at the sampling station from the detection channel.

2. The fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein There are n first conveying structures arranged in both the detection channel and the urgent channel, where n = m + 1. The n first conveying structures and the m transfer assemblies are arranged alternately in sequence. The first conveying structure includes: a first conveying roller rotatably connected to the frame. There are two first conveying rollers, and the two first conveying rollers are arranged at intervals in the length direction of the frame and rotatably connected to the frame; a first conveyor belt sleeved outside the two first conveying rollers and capable of rotating with the rotation of the conveying rollers; and a first motor fixedly arranged on the frame. The power output shaft of the first motor is in transmission connection with the power input shaft of any one of the two first conveying rollers.

3. The fully automatic chemiluminescence immunoassay analyzer according to claim 1 or 2, characterized in that, The transfer assembly includes: a slider provided with at least three conveying channels. The slider has a first position and a second position that can be switched with each other. When the slider is in the first position or the second position, there is a corresponding conveying channel for both the detection channel and the urgent channel; a second conveying structure corresponding to the conveying channel one by one. The second conveying structure is arranged on the slider; and a third driving structure arranged on the frame. The third driving structure is used to drive the slider to move from the first position to the second position or from the second position to the first position.

4. The fully automatic chemiluminescence immunoassay analyzer according to claim 3, wherein, There are four conveying channels. The slider has a first position, a second position, and a third position that can be switched with each other. When the slider is in the first position, the second position, or the third position, there is a corresponding conveying channel for both the urgent channel and the detection channel. When the slider is in the first position, the two middle conveying channels respectively correspond to the detection channel and the urgent channel. The third driving structure is used to drive the slider from the first position to the second position, from the second position to the first position, from the first position to the third position, or from the third position to the first position.

5. The fully automatic chemiluminescence immunoassay analyzer according to claim 4, wherein The second conveying structure includes: a second conveying roller arranged on the slider and rotatably connected to the slider. There are two second conveying rollers, and the two second conveying rollers are arranged at intervals in the length direction of the conveying channel; a second conveyor belt sleeved outside the two second conveying rollers and capable of rotating with the rotation of the second conveying rollers; and A second motor, which is fixedly arranged on the slider, and a power output shaft of the second motor is in transmission connection with a power input shaft of any one of the two second conveying rollers.

6. The fully automatic chemiluminescence immunoassay analyzer according to claim 4 or 5, characterized in that, The third driving structure includes: A third lead screw, which is rotatably connected to the frame; A third nut, which is sleeved on the third lead screw, and when the third lead screw is rotated, the third nut can move along the axial line direction of the third lead screw, and the third nut is fixedly connected to the slider; and A third motor, which is fixedly arranged on the frame, and a power output shaft of the third motor is in transmission connection with the third lead screw.

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