Biological sample storage system, calibration device and calibration method

Abstract

The invention discloses a biological sample storage system, a calibration device and a calibration method. The biological sample storage device comprises a box body defining a containing cavity, the containing cavity is provided with a biological sample cryopreservation frame, the biological sample cryopreservation frame defines at least one cryopreservation position, each cryopreservation position is used for storing a biological sample, and the calibration device comprises a box body defining a box body cavity; the measuring part is arranged in the box body cavity and is used for obtaining the position information of the cryopreservation position; the connecting assembly is arranged on the box body and used for being detachably arranged in the containing cavity. According to the biological sample storage system, the calibration device and the calibration method provided by the invention, the calibration device is detachably arranged in the accommodating cavity, so that the calibration device can be arranged in the accommodating cavity during calibration, and the calibration device is moved out of the accommodating cavity when calibration is not carried out, so that the calibration device is prevented from being influenced by cold energy; the calibration device is not easy to damage.

Description

Technical Field

[0001] The present application relates to the technical field of biological sample storage, and particularly to a biological sample storage system, a calibration device and a calibration method. Background Art

[0002] With the rapid development of the biopharmaceutical industry, large-scale biological sample banks have emerged, and the storage volume of biological samples has become larger and larger. Generally, biological samples such as tissues and cells in clinics or laboratories are stored in a biological sample storage device that uses cold energy to store biological samples. The accommodating cavity of this biological sample storage device has a biological sample freezing rack, and the biological sample freezing rack is used to store biological samples. However, over time, the biological sample freezing rack will deform or move, resulting in a change in the relative position between the storage position and the picking and placing device. At the same time, the deformation and misalignment of the picking and placing device such as a manipulator and other mechanisms will also cause a change in the relative position between the picking and placing device and the storage position. Therefore, it is necessary to obtain the position information of each freezing position of the storage position, so as to facilitate the calibration of each freezing position and avoid the picking and placing device being unable to accurately pick and place biological samples during automated operations. In the related art, a measuring device for measuring position information is directly provided on the picking and placing device in the accommodating cavity. Thus, the measuring device is easily affected by cold energy and is likely to cause damage to the measuring device. Summary of the Invention

[0003] In view of the above problems, the present application is proposed to provide a biological sample storage system, a calibration device and a calibration method that overcome the above problems or at least partially solve the above problems.

[0004] The present application provides a calibration device for a biological sample storage device. The biological sample storage device includes a box body that defines an accommodating cavity. The accommodating cavity is provided with a biological sample freezing rack, and the biological sample freezing rack defines at least one freezing position. Each freezing position is used to store biological samples. The calibration device includes: a box body that defines a box body cavity; a measuring member disposed in the box body cavity for obtaining the position information of the freezing position; and a connecting component disposed on the box body for detachably disposing in the accommodating cavity.

[0005] Optionally, a picking and placing device is movably disposed in the box body, and the picking and placing device is used to pick and place the biological samples stored in the freezing position; and the connecting component is used to detachably dispose on the picking and placing device.

[0006] Optionally, the cryopreservation positions are used to store biological samples through a biological sample cryopreservation box. The accommodation cavity has an inlet / outlet for the biological sample cryopreservation box to enter and exit the accommodation cavity. The picking and placing device is used to pick and place the biological sample cryopreservation box through the inlet / outlet when storing the biological sample, and drive the biological sample cryopreservation box to move; and the picking and placing device is used to pick the calibration device through the inlet / outlet when calibrating each of the cryopreservation positions, and drive the calibration device to move to the positions corresponding to each of the storage positions in sequence.

[0007] Optionally, the connection assembly includes at least one telescopic member, and the telescopic member is detachably arranged in the accommodation cavity through telescoping.

[0008] Optionally, the telescopic member is telescoped through a driving member and / or an elastic member.

[0009] Optionally, the at least one telescopic member includes a plurality of telescopic members with different telescopic directions.

[0010] Optionally, the calibration device further includes: a limiting member, which is movably arranged in the box body cavity, and the limiting member is used to limit the telescopic member.

[0011] Optionally, the calibration device further includes: at least one position sensor, which is used to detect the position of the limiting member.

[0012] Optionally, the box body includes a metal frame and a heat insulation plate connected to the metal frame.

[0013] Optionally, the calibration device further includes: a power supply, which is arranged in the box body cavity and is used to supply electrical energy to the calibration device.

[0014] Optionally, the calibration device further includes: a covering device, which is used to detachably cover at least a part of the outer surface of the box body, so that the external dimension of the calibration device is adjustable.

[0015] The present application also provides a biological sample storage system, including: a biological sample storage device, including a box body defining an accommodation cavity, a biological sample cryopreservation rack is arranged in the box body, the biological sample cryopreservation rack defines at least one cryopreservation position, and each of the cryopreservation positions is used to store biological samples; the calibration device as described in any one of the above, the connection assembly of the calibration device is used to be detachably arranged in the accommodation cavity, and the measuring member of the calibration device is used to obtain the position information of each of the cryopreservation positions.

[0016] The present application also provides a calibration method for a biological sample storage device. The biological sample storage device includes a box body defining a receiving cavity, a biological sample freezing rack is arranged in the receiving cavity, the biological sample freezing rack defines at least one freezing position, and each freezing position is used for storing biological samples. The calibration method includes: placing a calibration device into the receiving cavity, where the calibration device is any one of the above-mentioned calibration devices; enabling the calibration device to obtain the position information of each freezing position, so as to calibrate each freezing position; and removing the calibration device from the receiving cavity.

[0017] Optionally, a picking and placing device is movably arranged in the box body. The picking and placing device is used for picking and placing the biological samples stored in the freezing positions. And the step of placing the calibration device into the receiving cavity includes: placing the calibration device into the picking and placing device in the receiving cavity; the step of removing the calibration device from the receiving cavity includes: removing the calibration device from the receiving cavity through the picking and placing device.

[0018] Optionally, the freezing position is used for storing biological samples through a biological sample freezing box. The receiving cavity has an inlet and outlet for the biological sample freezing box to enter and exit the receiving cavity. The picking and placing device is used for picking the biological sample freezing box through the inlet and outlet when storing the biological samples, and driving the biological sample freezing box to move to the corresponding storage position; the step of placing the calibration device into the picking and placing device in the receiving cavity includes: placing the calibration device into the picking and placing device in the receiving cavity through the inlet and outlet; the step of enabling the calibration device to obtain the position information of each freezing position includes: enabling the picking and placing device to drive the calibration device to move to each storage position in sequence.

[0019] For the biological sample storage system, calibration device and calibration method provided by the present application, since the calibration device is detachably arranged in the receiving cavity, the calibration device can be arranged in the receiving cavity during calibration, and when calibration is not carried out, the calibration device is removed from the receiving cavity, avoiding the influence of cold on the calibration device, and the calibration device is not easily damaged. Description of the Drawings

[0020] Through the description of the present application with reference to the drawings below, other objects and advantages of the present application will be obvious and can help to comprehensively understand the present application.

[0021] Figure 1 is a schematic structural diagram of a biological sample storage device according to some embodiments of the present application; Figure 2 is a schematic diagram of a biological sample freezing rack, a picking and placing device and a calibration device according to some embodiments of the present application; Figure 3Schematic structural diagram of a calibration device according to some embodiments of the present application; Figure 4 Internal structural diagram of a calibration device according to some embodiments of the present application.

[0022] In the figure, 10 is a biological sample storage device, 100 is a box body, 110 is a receiving cavity, 120 is a biological sample cryopreservation rack, 121 is a cryopreservation position, 130 is a picking and placing device, 200 is a calibration device, 210 is a box body, 220 is a measuring member, 230 is a connecting component, 231 is a telescopic member, 232 is a driving member, 233 is an elastic member, and 240 is a power supply. Detailed implementation manners

[0023] To make the objectives, technical solutions, and advantages of the present application clearer, the technical solutions of the present application will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present application. Apparently, the described embodiments are only some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the described embodiments of the present application without creative efforts shall fall within the protection scope of the present application.

[0024] Unless otherwise defined, the technical terms or scientific terms used in the present application shall have the ordinary meanings understood by those of ordinary skill in the art to which the present application pertains.

[0025] This embodiment provides a calibration device 200 for a biological sample storage device 10. Figure 1 Schematic structural diagram of a biological sample storage device 10 according to some embodiments of the present application; Figure 2 Schematic diagram of a biological sample cryopreservation rack 120, a picking and placing device 130, and a calibration device 200 according to some embodiments of the present application; Figure 3 Schematic structural diagram of a calibration device 200 according to some embodiments of the present application; Figure 4 Internal structural diagram of a calibration device 200 according to some embodiments of the present application.

[0026] The biological sample storage device 10 includes a box body 100 defining a receiving cavity 110, the receiving cavity 110 is provided with a biological sample cryopreservation rack 120 and a movable transfer mechanism, the biological sample cryopreservation rack 120 defines at least one cryopreservation position 121, each cryopreservation position 121 is used for storing biological samples, the transfer mechanism is provided with a first positioning structure, and the calibration device 200 includes a box body 210, a measuring member 220, and a connecting component 230.

[0027] The box body 210 defines a box body cavity. The measuring member 220 is disposed in the box body cavity and is used to obtain the position information of the freezing position 121. The connecting component 230 is disposed on the box body 210. The connecting component 230 is provided with a second positioning structure for cooperating with the first positioning structure. The cooperation between the first positioning structure and the second positioning structure is used to fix the relative positions of the connecting component 230 and the transfer mechanism.

[0028] Through the arrangement of the first positioning structure and the second positioning structure, the relative positions of the calibration device 200 and the transfer mechanism of this biological sample storage system and its calibration device 200 are stabilized, so that the obtained position information is more accurate.

[0029] In some embodiments, the first positioning structure includes a positioning hole, and the second positioning structure includes a positioning protrusion. In other embodiments, the first positioning structure and the second positioning structure can be other structures such as a snap structure.

[0030] Among them, the transfer mechanism may include a picking and placing device 130. The picking and placing device 130 is used to pick and place the biological samples stored in the freezing position 121. The connecting component 230 is used to be detachably disposed on the picking and placing device 130.

[0031] That is to say, the biological sample storage device 10 of this embodiment can store and retrieve biological samples through the picking and placing device 130, improving the automation level. And in this embodiment, the calibration device 200 is disposed on the picking and placing device 130, and the picking and placing device 130 can be used to drive the calibration device 200 to move.

[0032] Specifically, the picking and placing device 130 may include a clamping jaw, a manipulator, a shovel plate, etc., and this embodiment does not limit this.

[0033] In some embodiments, the freezing position 121 is used to store biological samples through a biological sample freezing box. The accommodating cavity 110 has an inlet and outlet for the biological sample freezing box to enter and exit the accommodating cavity 110. The picking and placing device 130 is used to pick and place the biological sample freezing box through the inlet and outlet when storing biological samples, and drive the biological sample freezing box to move. That is to say, when storing biological samples, the picking and placing device 130 picks up biological samples through the inlet and outlet, and then moves in the accommodating cavity 110. When reaching the corresponding storage position, the picking and placing device 130 stores the biological samples at the corresponding storage position. When picking up biological samples, the picking and placing device 130 moves to the corresponding storage position, takes out the biological samples, and then moves the biological samples to the inlet and outlet, so that the biological samples can be taken out. Thus, the automation level of the biological sample storage device 10 is improved.

[0034] The pick-and-place device 130 is used to pick up the calibration device 200 through the inlet and outlet during the calibration of each cryopreservation position 121, and drive the calibration device 200 to move to the position corresponding to each storage position in sequence. Since the pick-and-place device 130 picks up and places biological samples at the cryopreservation position 121, it can move to the position corresponding to each storage position, which is convenient for driving the calibration device 200 to perform calibration. Moreover, this way of storing the cryopreservation box of biological samples enables the calibration device 200 to enter the accommodation cavity 110 without opening other larger door bodies of the biological sample storage device 10 (the inlet and outlet are used for the entry and exit of the cryopreservation box, which is relatively small and not convenient for manually or automatically placing the calibration device 200 on the pick-and-place device 130). Manually or automatically fixing the calibration device 200 to the pick-and-place device 130 simplifies the operation of personnel, avoids cold leakage, reduces the degree of internal frosting, and improves the user experience.

[0035] In some embodiments, the connection assembly 230 includes at least one telescopic member 231 (which can be the above-mentioned second positioning structure or can be independent of the second positioning structure), and the telescopic member 231 is detachably disposed in the accommodation cavity 110 (which can be the pick-and-place device 130 in the accommodation cavity 110) through telescoping. It can be understood that when the telescopic member 231 extends, it can protrude from the box body cavity so as to be connected to devices in the accommodation cavity 110 such as the pick-and-place device 130, and thus be fixed. When the telescopic member 231 retracts, the calibration device 200 can be released.

[0036] Among them, the telescopic member 231 can achieve telescoping through the driving member 232 and / or the elastic member 233. For example, the driving member 232 can be a motor, a cylinder, an electromagnet, etc., and the elastic member 233 can be a spring, a spring piece, rubber, etc. The driving member 232 can be effectively and stably controlled, and the setting of the elastic member 233 can save electricity.

[0037] The at least one telescopic member 231 includes a plurality of telescopic members 231 with different telescopic directions. Preferably, the plurality of telescopic members 231 can include at least two telescopic members 231 with opposite telescopic directions. Thereby, the stability of the calibration device 200 connected to the pick-and-place device 130 is ensured, and it is avoided from falling off during movement.

[0038] The calibration device 200 can further include a limiting member, which is movably disposed in the box body cavity, and the limiting member is used to limit the telescopic member 231. The limiting member can respectively limit the telescopic members 231 at different positions (for example, the extended state and the retracted state) through movement, so as to avoid the telescopic member 231 from retracting after extending during calibration, thereby avoiding the calibration device 200 from shaking and falling off, and ensuring smooth removal of the calibration device 200, and improving the practical experience. The limiting member can include a limiting block, a limiting baffle, etc., and can be limited through the edge of the limiting block or through the hole opened on the limiting block.

[0039] The calibration device 200 may further include at least one position sensor for detecting the position of the limiting member.

[0040] In some embodiments, the box body 210 includes a metal frame and a heat insulation plate connected to the metal frame. The metal frame can improve the structural strength, and the heat insulation plate can reduce the influence of cold on the internal components in the box body cavity. The calibration device 200 may further include a power supply 240 disposed in the box body cavity for supplying electrical energy to the calibration device 200. Thus, the calibration device 200 does not need to be wired for power supply in the accommodation cavity 110. The calibration device 200 may further include a covering device for detachably covering at least a part of the outer surface of the box body 210, so that the overall external dimension of the calibration device 200 is adjustable. Thus, the overall external dimension of the calibration device 200 can be adapted to different sizes of biological sample cryopreservation boxes, improving the applicability of the calibration device 200.

[0041] It can be understood that the calibration device 200 may further include a circuit board, which can be disposed in the accommodation cavity 110. The circuit board can place various electronic devices and can also implement functions such as voltage conversion and wireless transmission (such as Bluetooth).

[0042] This embodiment also provides a biological sample storage system, which includes a biological sample storage device 10 and any one of the above calibration devices 200.

[0043] The biological sample storage device 10 includes a box body 100 defining an accommodation cavity 110. A biological sample cryopreservation rack 120 is disposed in the box body 100. The biological sample cryopreservation rack 120 defines at least one cryopreservation position 121, and each cryopreservation position 121 is used for storing biological samples. The connection component 230 of the calibration device 200 is used for detachably disposing in the accommodation cavity 110, and the measuring member 220 of the calibration device 200 is used for obtaining the position information of each cryopreservation position 121.

[0044] This embodiment also provides a calibration method for the biological sample storage device 10. The biological sample storage device 10 includes a box body 100 defining an accommodation cavity 110. The accommodation cavity 110 is provided with a biological sample cryopreservation rack 120, and the biological sample cryopreservation rack 120 defines at least one cryopreservation position 121, and each cryopreservation position 121 is used for storing biological samples. The calibration method includes: placing the calibration device 200 into the accommodation cavity 110, where the calibration device 200 is any one of the above calibration devices 200; enabling the calibration device 200 to obtain the position information of each cryopreservation position 121 so as to calibrate each cryopreservation position 121; and removing the calibration device 200 from the accommodation cavity 110.

[0045] In some embodiments, a picking and placing device 130 is movably disposed within the box body 100. The picking and placing device 130 is configured to pick and place biological samples stored in the cryopreservation positions 121. The step of placing the calibration device 200 into the accommodation cavity 110 includes: placing the calibration device 200 into the picking and placing device 130 within the accommodation cavity 110; the step of removing the calibration device 200 from the accommodation cavity 110 includes: removing the calibration device 200 from the accommodation cavity 110 through the picking and placing device 130.

[0046] The cryopreservation positions 121 can be used to store biological samples through a biological sample cryopreservation box. The accommodation cavity 110 has an inlet and outlet for the biological sample cryopreservation box to enter and exit the accommodation cavity 110. The picking and placing device 130 is configured to pick the biological sample cryopreservation box through the inlet and outlet when storing biological samples, and drive the biological sample cryopreservation box to move to the corresponding storage position; the step of placing the calibration device 200 into the picking and placing device 130 within the accommodation cavity 110 includes: placing the calibration device 200 through the inlet and outlet into the picking and placing device 130 within the accommodation cavity 110; the step of enabling the calibration device 200 to obtain the position information of each cryopreservation position 121 includes: causing the picking and placing device 130 to drive the calibration device 200 to sequentially move to each storage position.

[0047] Regarding the embodiments of the present application, it should also be noted that, without conflict, the embodiments of the present application and the features in the embodiments can be combined with each other to obtain new embodiments.

[0048] The above is only the specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. The protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A calibration device for a biological sample storage device, the biological sample storage device including a box body defining a receiving cavity, the receiving cavity being provided with a biological sample freezing rack, the biological sample freezing rack defining at least one freezing position, each of the freezing positions being used for storing biological samples, characterized in that, The calibration device includes: a box body that defines a box body cavity; a measuring member disposed in the box body cavity for obtaining the position information of the freezing position; a connecting component disposed on the box body for detachably setting in the accommodating cavity.

2. The calibration device according to claim 1, wherein A picking and placing device is movably disposed in the box body, and the picking and placing device is used for picking and placing the biological sample stored in the freezing position; and the connecting component is used for detachably setting on the picking and placing device.

3. The calibration device according to claim 2, characterized in that, The freezing position is used for storing biological samples through a biological sample freezing box. The accommodating cavity has an inlet and outlet for the biological sample freezing box to enter and exit the accommodating cavity. The picking and placing device is used for picking and placing the biological sample freezing box through the inlet and outlet when storing the biological sample, and driving the biological sample freezing box to move; and the picking and placing device is used for picking the calibration device through the inlet and outlet when calibrating each freezing position, and driving the calibration device to sequentially move to the positions corresponding to each storage position.

4. The calibration device according to claim 1, characterized in that, The connecting component includes at least one telescopic member, and the telescopic member is detachably disposed in the accommodating cavity through telescoping.

5. The calibration device according to claim 4, wherein the telescopic member realizes telescoping through a driving member and / or an elastic member.

6. The calibration device according to claim 4, wherein the at least one telescopic member includes a plurality of telescopic members with different telescopic directions.

7. The calibration device according to claim 4, wherein It further includes: a limiting member movably disposed in the box body cavity, and the limiting member is used for limiting the telescopic member.

8. The calibration device according to claim 7, wherein It further includes: at least one position sensor for detecting the position of the limiting member.

9. The calibration device according to claim 1, wherein the box body includes a metal frame and a heat insulation plate connected to the metal frame.

10. The calibration device according to claim 1, wherein It further includes: a power supply disposed in the box body cavity for supplying electric energy to the calibration device.

11. The calibration device according to claim 1, characterized in that, It further includes: a covering device for detachably covering at least a part of the outer surface of the box body so that the external dimension of the calibration device is adjustable.

12. A biological sample storage system, characterized in that, It includes: a biological sample storage device, including a box body that defines an accommodating cavity. A biological sample freezing rack is disposed in the box body, and the biological sample freezing rack defines at least one freezing position, and each freezing position is used for storing biological samples; The calibration device according to any one of claims 1-11, wherein the connecting component of the calibration device is used for detachably setting in the accommodating cavity, and the measuring member of the calibration device is used for obtaining the position information of each freezing position.

13. A calibration method for a biological sample storage device, the biological sample storage device comprising a box body defining an accommodation cavity, the accommodation cavity being provided with a biological sample freezing rack, the biological sample freezing rack defining at least one freezing position, each of the freezing positions being used for storing a biological sample, characterized in that, The calibration method includes: Putting the calibration device into the accommodating cavity, and the calibration device is the calibration device according to any one of claims 1 to 11; Enabling the calibration device to obtain the position information of each freezing position, so as to calibrate each freezing position; Removing the calibration device from the accommodating cavity.

14. The calibration method according to claim 13, characterized in that, A picking and placing device is movably disposed in the box body, and the picking and placing device is used for picking and placing the biological sample stored in the freezing position, and the step of putting the calibration device into the accommodating cavity includes: putting the calibration device into the picking and placing device in the accommodating cavity; The step of moving the calibration device out of the accommodation cavity includes: moving the calibration device out of the accommodation cavity through the picking and placing device.

15. The calibration method according to claim 14, wherein The cryopreservation position is used to store biological samples through a biological sample cryopreservation box. The accommodation cavity has an inlet and outlet for the biological sample cryopreservation box to enter and exit the accommodation cavity. The picking and placing device is used to pick the biological sample cryopreservation box through the inlet and outlet when storing the biological sample, and drive the biological sample cryopreservation box to move to the corresponding storage position. The step of placing the calibration device into the picking and placing device in the accommodation cavity includes: placing the calibration device into the picking and placing device in the accommodation cavity through the inlet and outlet. The step of enabling the calibration device to obtain the position information of each cryopreservation position includes: driving the picking and placing device to drive the calibration device to move to each storage position in sequence.

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