Method and device for decocting traditional Chinese medicine decoction based on parameterized model

Abstract

The invention discloses a traditional Chinese medicine decoction decocting method and device based on a parameterized model, and belongs to the technical field of traditional Chinese medicine decoction decocting. S1, classification is carried out according to the water absorption coefficient S, the heat stability and the component release kinetics curve of traditional Chinese medicinal materials; s2, performing decoction parameter model setting aiming at different medicinal material types in a decoction device for decocting the traditional Chinese medicine decoction; s3, traditional Chinese medicinal materials needing to be decocted are added into the decoction device, the decoction device adjusts the water amount in the decoction device according to the water adding amount model corresponding to the medicinal material type, and then decoction is started; s4, in the decocting process, the decocting device adjusts the temperature and the pressure according to the temperature-pressure coupling model corresponding to the medicinal material category; s5, a threshold value is set in the decoction device in advance, decoction is stopped when the decoction device monitors that decoction reaches the threshold value, and through the mode, the problems that a traditional technology is low in standardization degree and poor in drug effect stability are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine decoction, and particularly relates to a method and device for decocting traditional Chinese medicine based on a parametric model. Background Art

[0002] Traditional Chinese medicine refers to substances used for preventing, treating, and diagnosing diseases and having the functions of rehabilitation and health care under the guidance of traditional Chinese medicine theory. Traditional Chinese medicine mainly comes from natural medicines and their processed products, including plant medicines, animal medicines, mineral medicines, and some chemical and biological product drugs. Since plant medicines are mostly used in traditional Chinese medicine, there is a saying that "all medicines are based on herbs". Traditional Chinese medicine decoction is an important form of clinical application of traditional Chinese medicine.

[0003] The traditional traditional Chinese medicine decoction process has the following defects:

[0004] 1): Coarse process: Only stipulating "first strong fire then slow fire", lacking quantitative control of temperature, pressure, and time, resulting in significant fluctuations in the extraction rate of effective components;

[0005] 2): Poor compatibility: No dynamic parameters are designed for the differences in the physical properties of medicinal materials, such as water absorption and heat sensitivity, which easily leads to the loss of volatile components or insufficient extraction of mineral components;

[0006] 3): Lagging quality evaluation: Relying on manual experience to judge the decoction end point, lacking real-time component detection means, and it is difficult to meet the requirements of GMP standardized production.

[0007] Therefore, it is urgent to design a method and device for decocting traditional Chinese medicine based on a parametric model to solve the above problems. Summary of the Invention

[0008] The technical problem to be solved by the present invention is: to solve the problems of low standardization degree and poor efficacy stability of the traditional process, and to achieve precise and intelligent control of the decoction process.

[0009] The technical solution adopted by the present invention to solve the technical problem is: a method for decocting traditional Chinese medicine based on a parametric model, including the following steps:

[0010] S1: Classify Chinese medicinal materials according to the water absorption coefficient S, thermal stability, and component release kinetic curve of Chinese medicinal materials, and the types of medicinal materials include rhizome types, flower and leaf types, and mineral types;

[0011] S2: Set decoction parameter models for different types of medicinal materials in a decoction device for traditional Chinese medicine decoction. The decoction parameter models include a water addition amount model and a temperature-pressure coupling model. The parameters of the water addition amount model include the water addition amount V, the water absorption coefficient S, the weight of the medicinal materials W, the variable parameter K1, and the variable parameter K2;

[0012] The water addition model expression is: V = K1×W + K2×S, where 5.8 < K1 < 6.2 and 0.28 < K2 < 0.32;

[0013] The temperature-pressure coupling model parameters include temperature T and pressure P;

[0014] The temperature-pressure coupling model expression is:

[0015] The unit of the water addition V is ml, the unit of the weight of the medicinal materials W is g, the unit of the temperature T is °C, and the unit of the pressure P is MPa;

[0016] S3: Add the traditional Chinese medicinal materials to be decocted into the decocting device. The decocting device adjusts the water volume in the decocting device according to the water addition model corresponding to the type of medicinal materials, and then starts decocting;

[0017] S4: During the decocting process, the decocting device adjusts the temperature and pressure according to the temperature-pressure coupling model corresponding to the type of medicinal materials;

[0018] S5: Set a threshold value in the decocting device in advance. When the decocting device monitors that the decoction reaches the threshold value, stop decocting.

[0019] As a preferred technical solution of the present invention, the water absorption parameter S is measured by a standard water absorption test.

[0020] As a preferred technical solution of the present invention, the thermal stability is determined based on thermogravimetric analysis and the decomposition temperature of high performance liquid chromatography.

[0021] As a preferred technical solution of the present invention, the component release kinetic curve uses a Franz diffusion cell to simulate the extraction rate during the decocting process.

[0022] As a preferred technical solution of the present invention, the decocting device includes a decocting pot, a central controller, a temperature component, a water volume component, and a pressure component. The temperature component, the central controller, the water volume component, and the pressure component are all arranged on the decocting pot. The central controller is electrically connected to the temperature component, the water volume component, and the pressure component respectively, and the decocting parameter model is set in the central controller.

[0023] As a preferred technical solution of the present invention, the central controller includes a setting module, a processing module, an output module, and an input module. The setting module, the output module, and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water volume component, and the pressure component, and the output module is respectively electrically connected to the temperature component, the water volume component, and the pressure component.

[0024] As a preferred technical solution of the present invention, the decocting device further includes a threshold monitoring component for monitoring the decoction, the threshold monitoring component is electrically connected to the central controller, the threshold monitoring component includes an infrared spectroscopy probe for monitoring the concentration of the decoction components and a conductivity sensor for monitoring the conductivity of the decoction, the infrared spectroscopy probe and the conductivity sensor are both arranged in the decocting pot 1, and the central controller is electrically connected to the infrared spectroscopy probe and the conductivity sensor respectively.

[0025] As a preferred technical solution of the present invention, the input module is electrically connected to the infrared spectroscopy probe and the conductivity sensor respectively.

[0026] As a preferred technical solution of the present invention, the wavelength range of the infrared spectroscopy probe is 900 - 2500 nm, the PLS model is used to predict the concentration of the decoction components, the conductivity sensor monitors the change of the ionic concentration of the decoction, and the sampling frequency is once per minute.

[0027] A decocting device for decocting traditional Chinese medicine decoction based on a parametric model, comprising a decocting pot, a central controller, a temperature component, a water volume component, a pressure component and a threshold monitoring component;

[0028] In the decocting device, the decocting parameter models for different types of traditional Chinese medicine are set, the decocting parameter models include a water addition model and a temperature - pressure coupling model, and the parameters of the water addition model include water addition volume V, water absorption coefficient S, weight of traditional Chinese medicine W, variable parameter K1 and variable parameter K2;

[0029] The expression of the water addition model is: V = K1×W + K2×S, 5.8 < K1 < 6.2, 0.28 < K2 < 0.32;

[0030] The parameters of the temperature - pressure coupling model include temperature T and pressure P;

[0031] The expression of the temperature - pressure coupling model is:

[0032] The unit of the water addition volume V is ml, the unit of the weight of traditional Chinese medicine W is g, the unit of the temperature T is °C, and the unit of the pressure P is MPa;

[0033] The temperature component, the central controller, the water volume component, and the pressure component are all arranged on the decocting pot. The central controller is electrically connected to the threshold monitoring component, the temperature component, the water volume component, and the pressure component respectively. The central controller includes a setting module, a processing module, an output module, and an input module. The setting module, the output module, and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water volume component, and the pressure component. The output module is respectively electrically connected to the temperature component, the water volume component, and the pressure component. The threshold monitoring component includes an infrared spectroscopy probe for monitoring the concentration of the decoction ingredients and a conductivity sensor for monitoring the conductivity of the decoction. The infrared spectroscopy probe and the conductivity sensor are both arranged in the decocting pot. The input module is respectively electrically connected to the infrared spectroscopy probe and the conductivity sensor;

[0034] A top decocting chamber and a bottom decocting chamber are arranged in the decocting pot in an up-and-down layout. A medicinal material dropping valve is arranged between the top decocting chamber and the bottom decocting chamber. The output module is electrically connected to the medicinal material dropping valve;

[0035] The temperature component includes a temperature sensor and a temperature adjustment mechanism. The temperature adjustment mechanism is arranged at the bottom of the bottom decocting chamber. The temperature sensor is arranged in the bottom decocting chamber. The input module is electrically connected to the temperature sensor. The output module is electrically connected to the temperature adjustment mechanism;

[0036] The water volume component includes a water supply mechanism, a drainage mechanism, and a water level sensor. The water supply mechanism is arranged on the decocting pot and at the top position of the bottom decocting chamber. The drainage mechanism is arranged on the decocting pot and at the bottom position of the bottom decocting chamber. The water level sensor is located in the bottom decocting chamber. The input module is electrically connected to the water level sensor. The output module is electrically connected to the water supply mechanism and the drainage mechanism;

[0037] The pressure component includes a pressure sensor, a pressure relief valve, and a pressure compensating pump. The pressure sensor is arranged in the decocting pot. The pressure relief valve and the pressure compensating pump are both arranged on the decocting pot. The input module is electrically connected to the pressure sensor. The output module is electrically connected to the pressure relief valve and the pressure compensating pump.

[0038] The beneficial effects of the present invention are reflected in:

[0039] 1. By establishing a linkage equation for temperature, pressure, and water volume, so as to be able to quantitatively control the temperature, pressure, and water volume, and at the same time combining parameters such as the water absorption coefficient of different medicinal materials, so as to better adapt the decoction to the physical properties of different medicinal materials.

[0040] 2. By cooperating the infrared spectroscopy probe with the conductivity sensor, the termination of decoction can be objectively determined.

[0041] 3. By adapting to different categories of medicinal materials, it can meet the needs of decocting various medicinal materials and better reflect the decocting effect. Description of the Drawings

[0042] Figure 1 is a partial sectional view of some parts of the decocting device of the present invention;

[0043] Figure 2 is the connection diagram of the central controller module of the present invention.

[0044] In the figure: 1. Decocting pot; 101. Top decocting chamber; 102. Bottom decocting chamber; 103. Medicinal material dropping valve; 104. Mesh plate; 2. Central controller; 3. Temperature adjustment mechanism; 4. Temperature sensor; 5. Water supply mechanism; 6. Drainage mechanism; 7. Water level sensor; 8. Pressure sensor; 9. Pressure relief valve; 10. Pressure supplement pump; 11. Infrared spectrum probe; 12. Conductivity sensor. Detailed Embodiment

[0045] Now, the present invention will be further described in detail with reference to the accompanying drawings.

[0046] Combined with the attached Figure 1-2 As shown, a traditional Chinese medicine decoction method and device based on a parametric model include a decocting pot 1, a top decocting chamber 101, a bottom decocting chamber 102, a medicinal material dropping valve 103, a mesh plate 104, a central controller 2, a temperature adjustment mechanism 3, a temperature sensor 4, a water supply mechanism 5, a drainage mechanism 6, a water level sensor 7, a pressure sensor 8, a pressure relief valve 9, a pressure supplement pump 10, an infrared spectrum probe 11, and a conductivity sensor 12.

[0047] Combined with the attached Figure 1-2 As shown, a traditional Chinese medicine decoction method based on a parametric model includes the following steps:

[0048] S1: Classify the Chinese medicinal materials according to the water absorption coefficient S, thermal stability, and component release kinetic curve of the Chinese medicinal materials. The categories of medicinal materials include rhizome, flower and leaf, and mineral;

[0049] Specifically, the water absorption coefficient S of rhizome is 0.8 - 1.2, the water absorption coefficient S of flower and leaf is 1.5 - 2.0, and the water absorption coefficient S of mineral is 0.3 - 0.5;

[0050] The water absorption parameter S is measured through a standard water absorption test;

[0051] The thermal stability is determined based on thermogravimetric analysis and the decomposition temperature of high performance liquid chromatography;

[0052] The component release kinetic curve adopts a Franz diffusion cell to simulate the extraction rate during the decocting process;

[0053] S2: Set the decocting parameter models for different types of traditional Chinese medicine materials in a decocting device for decocting traditional Chinese medicine decoctions. The decocting parameter models include a water addition model and a temperature-pressure coupling model. The parameters of the water addition model include the water addition volume V, the water absorption coefficient S, the weight of the traditional Chinese medicine materials W, the variable parameter K1, and the variable parameter K2;

[0054] Specifically, set the decocting modes for different types of traditional Chinese medicine materials in the decocting device for decocting traditional Chinese medicine decoctions;

[0055] For the decoction of rhizome materials, it is divided into preheating decoction and constant pressure decoction. The preheating decoction time is 4 - 6 min, preferably 5 min, and the constant pressure decoction time is 35 - 45 min, preferably 40 min. The preferred temperature range during the decocting process is 100°C - 110°C;

[0056] For the decoction of flower and leaf materials, it is divided into rapid temperature rise decoction and constant temperature decoction. The rapid temperature rise decoction time is 2 - 4 min, preferably 3 min, and the constant temperature decoction time is 10 - 20 min, preferably 15 min. The preferred temperature range during the decocting process is 80°C - 85°C;

[0057] For the decoction of mineral materials, it is divided into stepped temperature rise decoction and pressure holding decoction. The stepped temperature rise decoction is divided into 2 - 4 stages, and the stepped temperature rise decoction time is 8 - 12 min / stage, preferably 10 min / stage. The pressure holding decoction time is 50 - 70 min, preferably 60 min. The preferred temperature range during the decocting process is 105°C - 115°C;

[0058] The expression of the water addition model is: V = K1×W + K2×S, 5.8 < K1 < 6.2, 0.28 < K2 < 0.32;

[0059] Among them, the selection of K1 and K2 is obtained by summarizing historical experience;

[0060] The parameters of the temperature-pressure coupling model include the temperature T and the pressure P;

[0061] The expression of the temperature-pressure coupling model is:

[0062] When T ≤ 100, P does not adopt the temperature-pressure coupling model. At this time, the pressure is normal pressure, and the temperature is regulated by the PID algorithm;

[0063] The unit of the water addition volume V is ml, the unit of the weight of the traditional Chinese medicine materials W is g, the unit of the temperature T is °C, and the unit of the pressure P is MPa;

[0064] The decocting device includes a decocting pot 1, a central controller 2, a temperature component, a water quantity component, and a pressure component. The temperature component, the central controller 2, the water quantity component, and the pressure component are all arranged on the decocting pot 1;

[0065] The central controller 2 is electrically connected to the temperature component, the water quantity component, and the pressure component respectively. The decocting parameter model is set in the central controller 2, and at the same time, the decocting mode is set and selected in the central controller 2;

[0066] The central controller 2 includes a setting module, a processing module, an output module, and an input module. The setting module, the output module, and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water quantity component, and the pressure component, and the output module is respectively electrically connected to the temperature component, the water quantity component, and the pressure component;

[0067] S3: Add the traditional Chinese medicinal materials to be decocted into the decocting device. The decocting device adjusts the water quantity in the decocting device according to the water quantity model corresponding to the type of medicinal materials, and then starts to decoct;

[0068] Among them, add the traditional Chinese medicinal materials to be decocted into the decocting pot 1. The water quantity component adjusts the water quantity in the decocting pot 1 according to the water quantity model corresponding to the type of medicinal materials, and then starts to decoct;

[0069] Specifically, select the corresponding decocting mode according to the type of medicinal materials to ensure the decocting time and decocting temperature;

[0070] For rhizome herbs, select the rhizome herb decocting mode. The preferred preheating decocting time is 5 min, the preferred constant pressure decocting time is 40 min, the preferred decocting temperature range is 100 - 110 °C, and during the decocting process, the decocting temperature is dynamically adjusted by regulating the decocting pressure according to the temperature-pressure coupling model;

[0071] For flower and leaf herbs, select the flower and leaf herb decocting mode. The preferred rapid heating decocting time is 3 min, the preferred constant temperature decocting time is 15 min, the preferred decocting temperature range during the decocting process is 80 °C - 85 °C, the decocting temperature is less than 100, during the decocting process, the temperature-pressure coupling model is not used to adjust the temperature and pressure, normal pressure is adopted during the decocting process, and the temperature is adjusted by the PID algorithm to make the temperature amplitude ±1.5 °C;

[0072] For mineral herbs, select the mineral herb decocting mode. The preferred stepped heating decocting is divided into 3 stages, the preferred stepped heating decocting time is 10 min / stage, the preferred pressure holding decocting time is 60 min, the preferred decocting temperature range during the decocting process is 105 °C - 115 °C, and during the decocting process, the decocting temperature is dynamically adjusted by regulating the decocting pressure according to the temperature-pressure coupling model;

[0073] S4: During the decocting process, the decocting device adjusts the temperature and pressure according to the temperature-pressure coupling model corresponding to the type of medicinal materials.

[0074] Among them, during the decocting process, the temperature component and the pressure component adjust the temperature and pressure according to the temperature-pressure coupling model corresponding to the type of medicinal materials.

[0075] The decocting device further includes a threshold monitoring component for monitoring the decoction, and the threshold monitoring component is electrically connected to the central controller 2.

[0076] The threshold monitoring component includes an infrared spectroscopy probe 11 for monitoring the concentration of the components of the decoction and a conductivity sensor 12 for monitoring the conductivity of the decoction. The infrared spectroscopy probe 11 and the conductivity sensor 12 are both arranged in the decocting pot 1, and the central controller 2 is electrically connected to the infrared spectroscopy probe 11 and the conductivity sensor 12 respectively.

[0077] The input module is electrically connected to the infrared spectroscopy probe 11 and the conductivity sensor 12 respectively.

[0078] The wavelength range of the infrared spectroscopy probe 11 is 900 - 2500 nm, and the PLS model is used to predict the concentration of the components of the decoction. The conductivity sensor 12 monitors the change of the ionic concentration of the decoction, and the sampling frequency is once per minute.

[0079] S5: Thresholds are preset in the decocting device, and when the decocting device monitors that the decoction reaches the threshold, the decocting stops.

[0080] Among them, the thresholds are preset through the central controller 2, and when the threshold monitoring component monitors that the decoction reaches the threshold, the decocting stops.

[0081] Specifically, the conditions for stopping the decocting are set as:

[0082] The target components of the decoction ≥ the preset threshold, where the preset threshold is preset through the central controller 2. The selection of the threshold is set according to the specific medicinal materials being decocted, and the determination of the threshold is obtained through historical experience. The infrared spectroscopy probe 11 and the conductivity sensor are used to monitor the decoction, and component determination is performed through the generated near-infrared spectrum and conductivity change graph. For example, for baicalin, when the component content ≥ 1.2 mg / ml, it is the node for stopping the decocting.

[0083] Taking Sangju Decoction as an example:

[0084] Prescription: Mentha haplocalyx Briq. 12 g (flower and leaf type, S = 1.8), Chrysanthemi Flos 12 g (flower and leaf type, S = 1.7), Mori Folium 24 g (flower and leaf type, S = 1.9);

[0085] According to the water volume model expression, where K1 takes the intermediate value of 6 and K2 takes the intermediate value of 0.3;

[0086] The water addition for mint is 72.54 ml, the water addition for chrysanthemum is 72.51 ml, and the water addition for mulberry leaf is 144.57 ml;

[0087] The total water addition is 289.62 ml;

[0088] Select the decocting mode for flower and leaf types;

[0089] Stage 1: First, quickly heat up and decoct for a duration of 3 min;

[0090] Stage 2: Under normal pressure, regulate the temperature to 82°C ± 1°C through the PID algorithm for constant-temperature decocting, lasting for 15 min;

[0091] During the process, the concentration of menthol is monitored in real time through the infrared spectroscopy probe 11;

[0092] After decocting is completed, the retention rate of menthol is 89.2%, which is greater than 71.5% of the traditional method. The energy consumption during decocting is 0.68 kW·h, which is less than 1.05 kW·h of the traditional method;

[0093] Taking Huashi Daizhe Decoction as an example:

[0094] Prescription: Talc powder 30 g (mineral class, water absorption coefficient S = 0.4), hematite 30 g (mineral class, water absorption coefficient S = 0.5);

[0095] According to the water volume model expression, where K1 takes the intermediate value of 6 and K2 takes the intermediate value of 0.3;

[0096] The water addition for gypsum is 180.12 ml, and the water addition for hematite is 180.15 ml;

[0097] The total water addition is 360.27 ml;

[0098] Select the decocting mode for mineral classes;

[0099] Stage 1: Through the temperature-pressure coupling model, regulate the temperature and pressure, and perform staged heating and decocting. There are three stages in total, lasting for 30 min;

[0100] Stage 2: Subsequently, keep the pressure and decoct. Through the temperature-pressure coupling model, regulate the temperature and pressure, lasting for 55 min;

[0101] During the process, the decoction is monitored in real time through the conductivity sensor 12 to judge whether the standard for stopping decocting is reached;

[0102] After decocting, the calcium ion extraction rate is 95.2%, which is greater than 82.3% in the traditional case, and the energy consumption during decocting is reduced by 18%;

[0103] Taking Siwu Decoction as an example:

[0104] Prescription: Angelica sinensis 12g, Rehmannia glutinosa 15g, Paeonia lactiflora 10g, Ligusticum chuanxiong 8g (all are rhizome plants);

[0105] The water absorption coefficients S are 1.2, 1, 0.9, and 1.1 respectively;

[0106] According to the water volume model expression, where K1 takes the middle value of 6 and K2 takes the middle value of 0.3;

[0107] The added water volume is 271.26 ml;

[0108] Select the rhizome decocting mode;

[0109] Stage 1: The preheating and decocting duration is 5 min;

[0110] Stage 2: Subsequently, constant-pressure decocting is carried out, and the temperature and pressure are regulated through the temperature-pressure coupling model, with a duration of 40 min;

[0111] After decocting, the ferulic acid concentration is detected by an infrared spectroscopy probe ≥ 0.5 mg / mL;

[0112] After decocting, the extraction of active ingredients is increased by 12%, the residue rate of medicinal residues is reduced to 8%, the total time used is 45 min, and the time used is reduced by about 50% compared with traditional decocting.

[0113] Combined with the attached Figure 1-2 As shown, a decocting device for decocting traditional Chinese medicine decoctions based on a parametric model includes a decocting pot 1, a central controller 2, a temperature component, a water volume component, a pressure component, and a threshold monitoring component;

[0114] In the decocting device, the decocting parameter models for different types of medicinal materials are set. The decocting parameter models include a water volume model and a temperature-pressure coupling model. The parameters of the water volume model include the water volume V, the water absorption coefficient S, the weight of the medicinal material W, the variable parameter K1, and the variable parameter K2;

[0115] The expression of the water volume model is: V = K1×W + K2×S, 5.8 < K1 < 6.2, 0.28 < K2 < 0.32;

[0116] The parameters of the temperature-pressure coupling model include the temperature T and the pressure P;

[0117] The expression of the temperature-pressure coupling model is:

[0118] The water addition volume V is in the unit of ml, the medicinal material weight W is in the unit of g, the temperature T is in the unit of °C, and the pressure P is in the unit of MPa;

[0119] The temperature component, the central controller 2, the water volume component, and the pressure component are all arranged on the decocting pot 1. The central controller 2 is electrically connected to the threshold monitoring component, the temperature component, the water volume component, and the pressure component respectively. The central controller 2 includes a setting module, a processing module, an output module, and an input module. Among them, the setting module is used for data setting and operations. The setting module, the output module, and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water volume component, and the pressure component, and the output module is respectively electrically connected to the temperature component, the water volume component, and the pressure component. The threshold monitoring component includes an infrared spectroscopy probe 11 for monitoring the concentration of the decoction ingredients and a conductivity sensor 12 for monitoring the conductivity of the decoction. The infrared spectroscopy probe 11 and the conductivity sensor 12 are both arranged in the decocting pot 1. Preferably, the infrared spectroscopy probe 11 is sleeved with a quartz cover. The input module is respectively electrically connected to the infrared spectroscopy probe 11 and the conductivity sensor 12;

[0120] In the decocting pot 1, a top decocting chamber 101 and a bottom decocting chamber 102 are arranged in an up-and-down layout. A medicinal material falling valve 103 is arranged between the top decocting chamber 101 and the bottom decocting chamber 102. Specifically, a funnel-shaped mesh plate 104 is arranged between the top decocting chamber 101 and the bottom decocting chamber 102, and the medicinal material falling valve 103 is arranged on the mesh plate 104. The output module is electrically connected to the medicinal material falling valve 103;

[0121] The temperature component includes a temperature adjustment mechanism 3 and a temperature sensor 4. The temperature adjustment mechanism 3 is arranged at the bottom of the bottom decocting chamber 102, and the temperature sensor 4 is arranged in the bottom decocting chamber 102. The input module is electrically connected to the temperature sensor 4, and the output module is electrically connected to the temperature adjustment mechanism 3. The temperature in the bottom decocting chamber 102 is monitored in real time through the temperature sensor 4, and the decocting pot 1 is heated through the temperature adjustment mechanism 3, and the heating temperature is regulated at the same time;

[0122] The water volume component includes a water supply mechanism 5, a drainage mechanism 6, and a water level sensor 7. The water supply mechanism 5 is arranged on the decocting pot 1 and at the top position of the bottom decocting chamber 102. The drainage mechanism 6 is arranged on the decocting pot 1 and at the bottom position of the bottom decocting chamber 102. The water level sensor 7 is located inside the bottom decocting chamber 102. The input module is electrically connected to the water level sensor 7, and the output module is electrically connected to the water supply mechanism 5 and the drainage mechanism 6. By setting the water level sensor 7, the water level inside the bottom decocting chamber 102 is monitored to obtain the water volume. By setting the water supply mechanism 5 and the drainage mechanism 6 to cooperate with each other, the water volume inside the decocting pot 1 is adjusted;

[0123] The pressure component includes a pressure sensor 8, a pressure relief valve 9, and a pressure compensating pump 10. The pressure sensor 8 is arranged inside the decocting pot 1. The pressure relief valve 9 and the pressure compensating pump 10 are both arranged on the decocting pot 1. The input module is electrically connected to the pressure sensor 8, and the output module is electrically connected to the pressure relief valve 9 and the pressure compensating pump 10. By setting the pressure sensor 8, the pressure inside the decocting pot 1 is obtained. By setting the pressure relief valve 9 and the pressure compensating pump 10 to cooperate with each other, the pressure inside the decocting pot 1 is adjusted.

[0124] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and the descriptions in the specification are only preferred examples of the present invention and do not limit the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of the present invention claimed is defined by the appended claims and their equivalents.

Claims

1. A decocting method of traditional Chinese medicine decoction based on a parametric model, characterized in that: It includes the following steps: S1: Classify traditional Chinese medicinal materials according to the water absorption coefficient S, thermal stability, and component release kinetic curve of traditional Chinese medicinal materials. The types of medicinal materials include rhizome types, flower and leaf types, and mineral types; S2: Set the decoction parameter model for different types of medicinal materials in the decoction device for decocting traditional Chinese medicine decoction. The decoction parameter model includes the water addition model and the temperature-pressure coupling model. The parameters of the water addition model include the water addition volume V, the water absorption coefficient S, the weight of the medicinal materials W, the variable parameter K1, and the variable parameter K2; The expression of the water addition model is: V = K1×W + K2×S, 5.8 < K1 < 6.2, 0.28 < K2 < 0.32; The parameters of the temperature-pressure coupling model include the temperature T and the pressure P; The expression of the temperature-pressure coupling model is as follows: The unit of the water addition volume V is ml, the unit of the weight of the medicinal materials W is g, the unit of the temperature T is °C, and the unit of the pressure P is MPa; S3: Add the traditional Chinese medicinal materials to be decocted into the decoction device. The decoction device adjusts the water volume in the decoction device according to the water addition model corresponding to the type of medicinal materials, and then starts decocting; S4: During the decoction process, the decoction device adjusts the temperature and pressure according to the temperature-pressure coupling model corresponding to the type of medicinal materials; S5: Set a threshold in the decoction device in advance. When the decoction device monitors that the decoction reaches the threshold, stop decocting.

2. The decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 1, characterized in that: The water absorption parameter S is measured by a standard water absorption test.

3. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 1, characterized in that: The thermal stability is determined based on thermogravimetric analysis and the decomposition temperature of high-performance liquid chromatography.

4. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 1, characterized in that: The component release kinetic curve uses a Franz diffusion cell to simulate the extraction rate during the decoction process.

5. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 1, characterized in that: The decoction device includes a decoction pot, a central controller, a temperature component, a water volume component, and a pressure component. The temperature component, the central controller, the water volume component, and the pressure component are all arranged on the decoction pot. The central controller is electrically connected to the temperature component, the water volume component, and the pressure component respectively, and the decoction parameter model is set in the central controller.

6. The decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 5, characterized in that: The central controller includes a setting module, a processing module, an output module, and an input module. The setting module, the output module, and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water volume component, and the pressure component, and the output module is respectively electrically connected to the temperature component, the water volume component, and the pressure component.

7. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 6, characterized in that: The decoction device also includes a threshold monitoring component for monitoring the decoction. The threshold monitoring component is electrically connected to the central controller. The threshold monitoring component includes an infrared spectrum probe for monitoring the component concentration of the decoction and a conductivity sensor for monitoring the conductivity of the decoction. The infrared spectrum probe and the conductivity sensor are both arranged in the decoction pot 1, and the central controller is electrically connected to the infrared spectrum probe and the conductivity sensor respectively.

8. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 7, characterized in that: The input module is respectively electrically connected to the infrared spectrum probe and the conductivity sensor.

9. A decocting method of traditional Chinese medicine decoction based on a parametric model according to claim 7, characterized in that: The wavelength range of the infrared spectrum probe is 900 - 2500 nm, and the PLS model is used to predict the component concentration of the decoction. The conductivity sensor monitors the change in the ion concentration of the decoction, and the sampling frequency is once per minute.

10. A decocting device for decocting traditional Chinese medicine decoctions based on a parametric model, characterized in that: It includes a decocting pot, a central controller, a temperature component, a water volume component, a pressure component and a threshold monitoring component; In the decocting device, a decocting parameter model for different types of medicinal materials is set. The decocting parameter model includes a water addition model and a temperature-pressure coupling model. The parameters of the water addition model include water addition volume V, water absorption coefficient S, weight of medicinal materials W, variable parameter K1 and variable parameter K2; The expression of the water addition model is: V = K1×W + K2×S, 5.8 < K1 < 6.2, 0.28 < K2 < 0.32; The parameters of the temperature-pressure coupling model include temperature T and pressure P; The expression of the temperature-pressure coupling model is as follows: The unit of the water addition volume V is ml, the unit of the weight of medicinal materials W is g, the unit of the temperature T is °C, and the unit of the pressure P is MPa; The temperature component, the central controller, the water volume component and the pressure component are all arranged on the decocting pot. The central controller is electrically connected to the threshold monitoring component, the temperature component, the water volume component and the pressure component respectively. The central controller includes a setting module, a processing module, an output module and an input module. The setting module, the output module and the input module are all electrically connected to the processing module. The input module is respectively connected to the temperature component, the water volume component and the pressure component. The output module is respectively electrically connected to the temperature component, the water volume component and the pressure component. The threshold monitoring component includes an infrared spectrum probe for monitoring the concentration of the decoction ingredients and a conductivity sensor for monitoring the conductivity of the decoction. The infrared spectrum probe and the conductivity sensor are both arranged in the decocting pot. The input module is respectively electrically connected to the infrared spectrum probe and the conductivity sensor; In the decocting pot, a top decocting chamber and a bottom decocting chamber are arranged in an up-and-down layout. A medicinal material dropping valve is arranged between the top decocting chamber and the bottom decocting chamber. The output module is electrically connected to the medicinal material dropping valve; The temperature component includes a temperature sensor and a temperature adjustment mechanism. The temperature adjustment mechanism is arranged at the bottom of the bottom decocting chamber. The temperature sensor is arranged in the bottom decocting chamber. The input module is electrically connected to the temperature sensor. The output module is electrically connected to the temperature adjustment mechanism; The water volume component includes a water supply mechanism, a drainage mechanism and a water level sensor. The water supply mechanism is arranged on the decocting pot and is located at the top position of the bottom decocting chamber. The drainage mechanism is arranged on the decocting pot and is located at the bottom position of the bottom decocting chamber. The water level sensor is located in the bottom decocting chamber. The input module is electrically connected to the water level sensor. The output module is electrically connected to the water supply mechanism and the drainage mechanism; The pressure component includes a pressure sensor, a pressure relief valve and a pressure compensating pump. The pressure sensor is arranged in the decocting pot. The pressure relief valve and the pressure compensating pump are both arranged on the decocting pot. The input module is electrically connected to the pressure sensor. The output module is electrically connected to the pressure relief valve and the pressure compensating pump.

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