Control method and device of 131I production equipment

Abstract

The invention provides a control method and device for 131I production equipment, and the method comprises the steps: determining a first nuclear number N1 (0) of 130Te in 130TeO2 target at an initial moment according to the enrichment degree of 130Te in the 130TeO2 target under the condition that the 130TeO2 target is irradiated with thermal neutrons with a thermal neutron fluence rate # imgabs0 # in the 131I production equipment, and determining a second nuclear number N1 (0) of 130Te in 1g of 130TeO2 target at an initial moment according to the enrichment degree of 130Te in the 130TeO2 target; and according to # imgabs 1 # and N1 (0), determining the irradiation duration required when the growth rate of the specific activity of the 131I generated in the irradiation process is less than a preset growth rate and the radioactive purity of the 131I reaches a preset purity after the target duration of irradiation ending, performing irradiation control on the 30TeO2 target according to the irradiation duration, and controlling the duration of irradiation ending according to the target duration. By means of the method, the 131I production equipment can obtain the 131I with the radioactive purity reaching the preset purity.

Description

Technical Field

[0001] This application relates to the field of computer technology, and in particular, to a 131 control method and device for I production equipment. Background Art

[0002] The half-life of iodine-131 ( 131 I) is 8.02 days, and it decays to xenon-131 ( 131 Xe) through 100% β decay. The maximum energy of the β rays emitted during the decay is 606.5 keV, and it is the most commonly used radioactive drug for treating thyroid diseases at present.

[0003] During the process of generating 131 I by 131 I production equipment, the generated 131 I, under thermal neutron irradiation, undergoes the 131 I(n,γ) 132 I reaction to generate 132 I, thus affecting 131 the radioactive purity of I. Therefore, how to control the 131 I production equipment so that the 131 I production equipment can generate 131 I with a radioactive purity meeting the preset purity is very important. Summary of the Invention

[0004] This application proposes a 131 control method and device for I production equipment.

[0005] One embodiment of this application proposes a 131 control method for I production equipment. The method includes: when it is determined that 131 in the I production equipment, the TeO2 target is irradiated with thermal neutrons at a thermal neutron fluence rate of 130 , determine the first number of nucleons N1(0) of 130 Te in the 130 TeO2 target at the initial moment for 1 gram according to the 130 enrichment of 130 Te in the TeO2 target; determine the first moment corresponding to when the growth rate of the specific activity of I generated during the irradiation of the 30 TeO2 target is less than the preset growth rate according to the 131 thermal neutron fluence rate and the first number of nucleons N1(0), and determine the irradiation duration of the 130 TeO2 target irradiation according to the first moment and the initial moment, where the first moment is for the 130The moment when the TeO2 target ends irradiation; according to the thermal neutron fluence rate and the first nucleon number N1(0), determine the 131 Te, the 131 I and 132 I at the first moment, where the 130 Te is irradiated by thermal neutrons to generate 131 Te, and the 131 Te decays by β to 131 I, the 131 I is irradiated by thermal neutrons to generate 132 I; according to the 131 Te at the first moment, the 131 I at the first moment and the 132 I at the first moment, determine the target duration after the irradiation ends when the 131 I reaches a preset purity; according to the irradiation duration, control the 30 TeO2 target for irradiation and control the duration of the end of irradiation according to the target duration, so that the 131 I production equipment obtains 131 I with a radioactive purity reaching the preset purity.

[0006] Another embodiment of the present application proposes a 131 Control device for I production equipment, the device includes: a first determination module, used for determining in the case of irradiating 131 TeO2 target in the I production equipment with thermal neutrons at a thermal neutron fluence rate , according to the 130 Enrichment of Te in the TeO2 target, determine the first nucleon number N1(0) of 130 Te in 1 gram of the 130 TeO2 target at the initial moment; a second determination module, used for determining according to the thermal neutron fluence rate 130 TeO2 target at the initial moment; a second determination module, used for determining according to the thermal neutron fluence rate 130 TeO2 target at the initial moment; a second determination module, used for determining according to the thermal neutron fluence rate and the first nucleon number N1(0), determine the first moment corresponding to when the specific activity growth rate of the 30 TeO2 target during the irradiation process is less than a preset growth rate, and according to the first moment and the initial moment, determine the 131 I irradiation duration of the TeO2 target, where the first moment is the moment when the 130 TeO2 target ends irradiation; a third determination module, used for determining according to the thermal neutron fluence rate 130 TeO2 target ends irradiation; a third determination module, used for determining according to the thermal neutron fluence rate and the first nucleon number N1(0), determine the 131Te, 131 I and 132 I is the number of nucleons at the first moment, wherein the 130 Te is generated by thermal neutron irradiation 131 Te, and the 131 Te decays into 131 I, said 131 I is generated by thermal neutron irradiation 132 I; a fourth determination module, for determining 131 The number of nucleons of Te at the first moment, 131 The number of nucleons at the first moment and the 132 I is the number of nuclei at the first moment, and after determining the target duration of irradiation completion, 131 The radioactive purity of I reaches a preset purity; a control module is used to control the 30 The TeO2 target is irradiated and controlled, and the duration of the irradiation end is controlled according to the target duration, so that the 131 I production equipment to obtain radioactive purity reaching the preset purity 131 I.

[0007] Another aspect of the present application provides a 131 I production equipment, comprising: a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor implements the embodiments of the present application when executing the computer program 131 I. Control method of production equipment.

[0008] Another aspect of the present application provides a computer-readable storage medium having a computer program stored thereon, which implements the embodiments of the present application when the computer program is executed by a processor. 131 I. Control method of production equipment.

[0009] Another aspect of the present application provides a computer program product, including a computer program, which implements the embodiments of the present application when the computer program is executed by a processor. 131 I. Control method of production equipment.

[0010] The technical solution provided by the embodiments of the present application may have the following beneficial effects:

[0011] In determining 131 I production equipment with thermal neutron injection rate Thermal neutron irradiation 130 In the case of TeO2 target, according to 130 TeO2 target 130 Te enrichment, determine the initial moment 1g 130In the TeO2 target 130 The first nucleon number N1(0) of Te, and according to the thermal neutron fluence rate and the first nucleon number N1(0), determine during the irradiation 30 of the TeO2 target 131 The growth rate of the specific activity of I is less than the preset growth rate at the corresponding first moment, and according to the first moment and the initial moment, determine 130 the irradiation duration of the TeO2 target irradiation, and according to the thermal neutron fluence rate and the first nucleon number N1(0), determine 131 Te, 131 I and 132 the nucleon numbers of I at the first moment, and according to 131 Te, 131 I and 132 the nucleon numbers of I at the first moment, after determining the target duration of the end of irradiation 131 the radioactive purity of I reaches the preset purity, and according to the irradiation duration, perform irradiation control on 30 the TeO2 target, and control the duration of the end of irradiation according to the target duration, so that 131 the I production equipment obtains I with a radioactive purity reaching the preset purity 131 Thus, according to the determined irradiation duration and target duration, the control of the 131 I production equipment is accurately realized, so that 131 the I production equipment can obtain I with a radioactive purity reaching the preset purity 131 I. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The drawings are used to better understand the solution and do not limit the present application. Among them:

[0013] Figure 1 is a schematic flowchart of a control method for an 131 I production equipment according to an embodiment of the present application;

[0014] Figure 2 is a diagram including 130 Te, 131 Te, 131 I and 131 an example diagram of the reaction chain between Xe;

[0015] Figure 3 is an example diagram of the curve of the first variation relationship A1(t);

[0016] Figure 4 is 132 an example diagram of the curve of the variation relationship A4(t) of the specific activity of I with time;

[0017] Figure 5 It is an example diagram including a curve of a third variation relationship and a curve of a fourth variation relationship;

[0018] Figure 6 It is according to an embodiment of the present application 131 The structural schematic diagram of the control device of the I production equipment;

[0019] Figure 7 It is according to an embodiment of the present application 131 The structural block diagram of the I production equipment. Specific implementation manners

[0020] The embodiments of the present application will be described in detail below. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to explain the present application, and should not be construed as limiting the present application.

[0021] The following describes the 131 Control method, device of the I production equipment, 131 I production equipment and storage medium with reference to the accompanying drawings.

[0022] Figure 1 It is according to an embodiment of the present application 131 The flow schematic diagram of the control method of the I production equipment.

[0023] Among them, it should be noted that the 131 Control method of the I production equipment is executed by the 131 Control device of the I production equipment. The 131 Control device of the I production equipment in this embodiment can be implemented in a software and / or hardware manner. Among them, the 131 Control device of the I production equipment in this example can be configured in the 131 I production equipment.

[0024] As Figure 1 shown, the 131 Control method of the I production equipment may include:

[0025] Step 101, when it is determined that 131 in the I production equipment, the TeO2 target is irradiated with thermal neutrons at a thermal neutron fluence rate of , according to the 130 enrichment degree of Te in the TeO2 target, determine the amount of 1 gram of 130 Te in the TeO2 target at the initial moment 130 , and 130 in the TeO2 target 130The first nucleon number N1(0) of Te.

[0026] Among them, tellurium dioxide - 130 130 The TeO2 target is a target formed by the combination of tellurium - 130 (which can also be called tellurium - 130 isotope) and oxygen element.

[0027] Among them, the initial moment refers to 130 The moment when the TeO2 target starts to be irradiated, which can also be called the 0th moment. Among them, the initial moment is often represented by t = 0.

[0028] In an embodiment of the present application, it can be based on 130 In the TeO2 target 130 The enrichment degree K of Te, from the corresponding relationship between the enrichment degree and the nucleon number, obtain the first nucleon number N1(0) of tellurium - 130 ( 130 Te) in 1 gram of the TeO2 target at the initial moment. 130 Te) in 1 gram of the TeO2 target at the initial moment.

[0029] In another embodiment of the present application, the formula for calculating N1(0) is:

[0030]

[0031] Among them, M represents 130 The relative atomic mass of the TeO2 target; K represents 130 In the TeO2 target 130 The enrichment degree of Te; N A Represents Avogadro's constant.

[0032] Among them, 130 The relative atomic mass of the TeO2 target refers to 130 The sum of the relative atomic masses of all atoms in the TeO2 target.

[0033] For example, taking 130 The TeO2 target with the enrichment degree K of Te being 99% as an example, at the initial moment, the first nucleon number of tellurium - 130 in 1 gram 130 of the TeO2 target 130 The first nucleon number of tellurium - 130 in the TeO2 target

[0034] Step 102, determine the first moment corresponding to when the growth rate of the specific activity of I generated during the irradiation of the TeO2 target is less than the preset growth rate according to the thermal neutron fluence rate and the first nucleon number N1(0), and determine the irradiation duration of the TeO2 target according to the first moment and the initial moment. Among them, the first moment is for 30 During the process of irradiating the TeO2 target, the 131 Growth rate of the specific activity of I generated is less than the preset growth rate, and according to the first moment and the initial moment, determine 130 The irradiation duration of the TeO2 target irradiation, where the first moment is for 130The moment when the irradiation of the TeO2 target ends.

[0035] Wherein, the preset growth rate is a growth rate set according to actual requirements. For example, the preset growth rate can be 0.1%.

[0036] It should be noted that the first moment refers to 131 The moment corresponding to when the growth rate of the specific activity of I first reaches less than the preset growth rate.

[0037] In this embodiment, the first moment can be subtracted from the initial moment to obtain 130 The irradiation duration of the TeO2 target irradiation.

[0038] It should be noted that after the first moment, the irradiation of the 30 TeO2 target can be ended, that is, after the first moment, the TeO2 target is no longer irradiated 30 TeO2 target, that is, 30 The irradiation of the TeO2 target ends.

[0039] In some embodiments, in order to accurately determine the first moment, correspondingly, according to the thermal neutron fluence rate And the first number of nucleons N1(0) to determine the 30 TeO2 target during the irradiation 131 A possible implementation method for the moment corresponding to when the growth rate of the specific activity of I is less than the preset growth rate is: according to the thermal neutron fluence rate And the first number of nucleons N1(0) to determine the 30 TeO2 target during the 131 First change relationship of the specific activity of I with time; according to the first change relationship, determine 131 The first moment corresponding to when the growth rate of the specific activity of I is less than the preset growth rate.

[0040] Wherein, the expression of the first change relationship A3(t):

[0041]

[0042] It should be noted that λ3 represents 131 The decay constant of I; N3(t) represents the 130 TeO2 target during the irradiation 131 Number of nucleons of I at time t; m represents 130 The mass of the TeO2 target. Since in this embodiment 130 The mass m of the TeO2 target is 1 gram, therefore, A3(t) can be expressed as:

[0043] A3(t) = λ3N3(t)

[0044] Among them, it should be noted that the expression of N3(t) is:

[0045]

[0046] Among them, σ1 and σ3 are respectively 130 the thermal neutron capture cross section (b) of Te and 131 I; is the thermal neutron fluence rate (n / (cm 2 ·s)); λ2 represents 131 the decay constant of Te; λ3 represents 131 the decay constant of I.

[0047] In order to clearly understand this application, the process of obtaining the expression of N3(t) will be described exemplarily below.

[0048] Among them, it can be understood that after irradiating the 130 TeO2 target with thermal neutrons, during the irradiation of the 130 TeO2 target, 130 in the 130 TeO2 target, 131 Te is generated by the irradiation of thermal neutrons to form 131 Te, and 131 Te decays to 131 I through β decay, 131 I decays to 131 Xe through β decay, and 132 I is generated by the irradiation of thermal neutrons to form 130 I. Among them, an example diagram of the reaction chain among 131 Te, 131 Te, 131 I and Figure 2 Xe is shown as

[0049] Therefore, by combining the relationships among the various substances in the above reaction chain, it can be determined that during the irradiation of the 130 TeO2 target, 130 the rates of change of the nucleon numbers of 131 Te, 131 Te and

[0050]

[0051] In the above equations:

[0052] λ1(t), N2(t), and N3(t) are respectively the nucleon numbers of 130 Te, 131 Te, 131 I at time t;

[0053] σ1 and σ3 are respectively 130 Te and 131 the thermal neutron capture cross sections (b) of I;

[0054] is the thermal neutron fluence rate (n / (cm 2 ·s));

[0055] λ2 and λ3 are respectively 131 Te and 131 the decay constants (s -1 ) of I;

[0056] T represents time, and the unit of time is seconds (s).

[0057] Among them, at the initial moment, that is, when t = 0, 131 Te and 131 the number of nucleons of I is zero, that is, N2(0) = 0, N3(0) = 0. Therefore, the above equations can be simplified to:

[0058]

[0059]

[0060] In the formula, N1(0) is the number of the first nucleons of 130 Te at the initial moment.

[0061] For example, taking 130 Te with an enrichment degree K of 99% 130 TeO2 target as an example, at the initial moment, the number of the first nucleons of tellurium-130 in 1 gram 130 TeO2 target The preset growth rate is 0.1%. Through formula (2) and formula (3), the expression of the first variation relationship A1(t) can be obtained. Among them, an example diagram of the curve of the first variation relationship A1(t) is as Figure 3 shown. Among them, it should be noted that Figure 3 the abscissa in represents the irradiation time, and the ordinate represents 131 the specific activity of I. Among them, Figure 3 the irradiation time in is taken as an example in days (day, d). Combining Figure 3 it can be seen that the activity of I generated by 1 gram of TeO2 increases gradually with the increase of the irradiation duration, 131 the specific activity of I increases gradually, but when reaching the first moment, 131 the growth rate of the specific activity of I is less than 0.1% for the first time, and after the first moment, 131 I's specific activity growth rate is less than 0.1% for the first time, and after the first moment, 131The growth rate of the specific activity of I hardly changes. Additionally, through calculation, it can be obtained that the first moment is 53 days. Correspondingly, based on the first moment and the initial moment, when the radiation duration is 53 days, 131 the growth rate of the specific activity of I can reach less than the preset growth rate. Additionally, at the end of the irradiation of 1 g 130 of the TeO2 target, 131 the specific activity of I is 1.449 curies per gram (Ci / g).

[0062] Step 103: Determine the number of nucleons of Te, 131 I, and 131 I at the first moment according to the thermal neutron fluence rate 132 and the first number of nucleons N1(0), where 130 Te is irradiated by thermal neutrons to generate 131 Te, and 131 Te decays by β to 131 I, 131 I is irradiated by thermal neutrons to generate 132 I.

[0063] In this embodiment, a possible implementation of determining the number of nucleons of Te, 131 I, and 131 I at the first moment according to the thermal neutron fluence rate 132 and the first number of nucleons N1(0) is as follows: Determine the relationship between the number of nucleons of Te, I, and 30 I changing with time respectively during the irradiation of 131 the TeO2 target; Determine the number of nucleons of 131 Te at the first moment according to the relationship between the number of nucleons of 132 Te changing with time during the irradiation of 30 the TeO2 target; Determine the number of nucleons of 131 I at the first moment according to the relationship between the number of nucleons of 131 I changing with time during the irradiation of 30 the TeO2 target; Determine the number of nucleons of 131 I at the first moment according to the relationship between the number of nucleons of 131 I changing with time during the irradiation of 30 the TeO2 target; Determine the number of nucleons of 132 I at the first moment according to the relationship between the number of nucleons of 132 I changing with time during the irradiation of

[0064] Among them, it should be noted that during the irradiation of 30 the TeO2 target 131The expression for the variation of the nucleon number of Te with time is given by Equation (8); during the irradiation 30 of the TeO2 target 131 the expression for the variation of the nucleon number of I with time is given by Equation (3) or Equation (9), where it should be noted that Equation (3) and Equation (9) are the same.

[0065] Among them, 131 I passes through 131 I(n,γ) 132 and the reaction of I will generate 132 I impurities, 132 and I will continue to β decay to 132 Xe, 132 and the half-life of I is 2.284 h. Thus, the expression for the rate of change of the nucleon number of I with time is listed as: 132 The expression for the rate of change of the nucleon number of I with time is:

[0066]

[0067] In the formula: N4(t) is the nucleon number of I at time t; λ4 is 132 the decay constant of I (s 132 ). -1 )

[0068] The formula can be simplified to:

[0069]

[0070] Among them, it can be understood that through Equation 11, the expression for the variation of the specific activity of I with time A4(t) can be determined as: 132 The expression for the variation of the specific activity of I with time A4(t) is:

[0071] A4(t) = λ4N4(t) (12)

[0072] Among them, it should be noted that according to Equation (8), the nucleon number N2(t1) of Te at the first moment t1 can be determined; according to Equation (9), the nucleon number N3(t1) of I at the first moment t1 can be determined; according to Equation (10), the nucleon number N4(t1) of I at the first moment t1 can be determined. 131 131 132

[0073] Continuing with the above example, including 132 an example graph of the curve of the variation of the specific activity of I with time A4(t), as Figure 4 shown. It should be noted that Figure 4 the curve in 30 shows that during the irradiation 132The specific activity of I changes with time. From this curve, it can be seen that as the irradiation duration increases for the I generated from 1 g of TeO2, 132 the activity of I gradually increases. 132 The specific activity of I gradually increases, but after reaching the first moment, 132 the growth rate of the specific activity of I is relatively small. Among them, it can be determined that when 30 the irradiation of the TeO2 target is completed, that is, at the first moment of 53, the 132 specific activity of I is 0.00581 Ci / g.

[0074] Step 104, according to 131 the number of nucleons of Te at the first moment, 131 the number of nucleons of I at the first moment, and 132 the number of nucleons of I at the first moment, after determining the target duration of the end of irradiation, 131 the radioactive purity of I reaches the preset purity.

[0075] Among them, the preset purity is the purity preset according to actual needs. For example, in order to meet the needs of subsequent disease treatment, the preset purity can be 99.9%.

[0076] In this embodiment, a possible implementation manner of step 104 is: according to 131 the number of nucleons of Te at the first moment and 131 the number of nucleons of I at the first moment, determine 130 the third change relationship of the specific activity of I with time after the irradiation of the TeO2 target ends; according to 131 the number of nucleons of I at the first moment, determine 132 the fourth change relationship of the specific activity of I with time after the irradiation of the TeO2 target ends; according to the third change relationship and the fourth change relationship, determine 130 the target duration of the end of the irradiation of the TeO2 target, after which 132 the radioactive purity of I reaches the preset purity. 130 131 132 131

[0077] In this embodiment, after the irradiation of the target is completed, since 132 the half-life of I is relatively short, its specific activity will rapidly decrease with time, while for 131 I, due to its relatively long half-life, its change in specific activity in a short time is relatively small. Among them, after the irradiation of the target is completed, 131 the derivation process of the expression of the change relationship of the specific activity of I and 132 I with time is as follows:

[0078] Since no neutron capture reaction occurs after the irradiation ends, only 131 Te,131 I and 132 the β decay of I, the following equation can be listed:

[0079]

[0080] It can be simplified to:

[0081]

[0082]

[0083]

[0084] In the formula, t1 is the first moment, that is, the moment when the target piece leaves the reactor after reaching the irradiation time; N2(t1), N3(t1) and N4(t1) are the number of nucleons of 131 Te, 131 I and 132 I at the moment of t1 respectively.

[0085] Among them, after the irradiation ends, 131 the A3 ′ (t) expression of the third variation relationship of the specific activity of I with time is:

[0086]

[0087] Among them, after the irradiation ends, 132 the A4 ′ (t) expression of the fourth variation relationship of the specific activity of I with time is:

[0088]

[0089] Continuing with the above example, assume the preset purity is 99.9%. After the irradiation ends, according to Formula 19 and Formula 20, it can be determined that after the 30 TeO2 target piece finishes irradiation 131 the curve of the third variation relationship of the specific activity of I with time and 132 the curve of the fourth variation relationship of the specific activity of I with time, among which, an example graph including the curve of the third variation relationship and the curve of the fourth variation relationship is as Figure 5 shown, among which, it should be noted that Figure 5 the mark "A" in represents the curve of the third variation relationship of the specific activity of I with time after the irradiation ends; the mark "B" represents the curve of the fourth variation relationship of the specific activity of I with time after the irradiation ends, among which, it should be noted that the abscissa represents time t, and the unit of time t is hour (h). Since there are a large number of 131 in the target piece at the end of the irradiation 132 131 ​Te, 131 Te is generated by β decay 131 I, and its half-life is much shorter than 131 The half-life of I, therefore, is 131 The specific activity of I will increase rapidly, and 132 I has a short half-life and its specific activity decreases rapidly. Through the curve of the first change relationship and the curve of the second change relationship, it can be determined that 4.6 hours (h) after the end of irradiation 131 The radioactive nucleus purity of I reaches 99.9%.

[0090] In this embodiment, according to the third change relationship and the fourth change relationship, it is determined 130 After the target time of TeO2 target irradiation is completed 131 One possible way to achieve the preset purity of the radioactive purity of I is: 130 After the irradiation of the TeO2 target is completed, the multiple second moments are traversed in sequence according to the time sequence of the multiple second moments, and for the traversed second moments, according to the third change relationship, the 131 I is the first specific activity at the second moment traversed; according to the fourth change relationship, determine 132 I is the second specific activity at the second time point traversed; according to the first specific activity and the second specific activity, determine 131 I is the radioactive purity at the second moment of traversal; when the radioactive purity reaches the preset purity, the target duration is determined according to the second moment of traversal and the first moment, and the traversal is ended.

[0091] It should be noted that, when it is determined that the radioactivity purity has not reached the preset purity, the next second moment is traversed continuously until the second moment when the radioactivity purity reaches the preset purity is obtained.

[0092] In this embodiment, the target duration may be obtained by subtracting the first moment from the traversed second moment.

[0093] Step 105, according to the irradiation time, 30 The TeO2 target is irradiated and the irradiation end time is controlled according to the target time, so that 131 I production equipment to obtain radioactive purity to reach the preset purity 131 I.

[0094] It should be noted that the enrichment in this embodiment is 99%, and the thermal neutron injection rate is 5×10 13 n / (cm 2 ·s) is only an example, and the enrichment and thermal neutron fluence rate may also take other values. This embodiment does not specifically limit the enrichment and thermal neutron fluence rate.

[0095] Based on the above description, it can be seen that in the method of this embodiment, after determining 130 the enrichment of Te in the TeO2 target and the number of first nucleons N1(0) of Te in 1 gram of the TeO2 target at the initial moment 130 the number of first nucleons N1(0) of Te in the TeO2 target at the initial moment 130 the TeO2 target 130 the number of first nucleons N1(0) of Te in the TeO2 target at the initial moment 30 the irradiation time of the TeO2 target and the target duration at the end of irradiation 131 the radioactive purity of I reaches the preset purity.

[0096] The control method of the I production equipment provided by the embodiment of the present application, when determining 131 the I production equipment is irradiated with thermal neutrons at a thermal neutron fluence rate 131 the I production equipment is irradiated with thermal neutrons at a thermal neutron fluence rate of 130 the TeO2 target, according to 130 the enrichment of Te in the TeO2 target 130 the number of first nucleons N1(0) of Te in 1 gram of the TeO2 target at the initial moment 130 the TeO2 target 130 the number of first nucleons N1(0) of Te in the TeO2 target at the initial moment and the number of first nucleons N1(0), determine the first moment corresponding to the growth rate of the specific activity of the generated I during the irradiation of 30 the TeO2 target being less than the preset growth rate, and according to the first moment and the initial moment, determine 131 the irradiation duration of the TeO2 target, and according to the thermal neutron fluence rate 130 the TeO2 target, and according to the thermal neutron fluence rate and the number of first nucleons N1(0), determine 131 Te, 131 I and 132 the number of nucleons of I at the first moment, and according to 131 Te, 131 I and 132 the number of nucleons of I at the first moment, determine the target duration at the end of irradiation after 131 the radioactive purity of I reaches the preset purity, and according to the irradiation duration, control 30 the TeO2 target for irradiation, and control the duration at the end of irradiation according to the target duration, so that 131 the I production equipment obtains I with a radioactive purity reaching the preset purity. Thus, according to the determined irradiation duration and target duration, the control of 131 the I production equipment is accurately realized, so that 131 the I production equipment can obtain I with a radioactive purity reaching the preset purity. 131 the I production equipment can obtain I with a radioactive purity reaching the preset purity. 131 I.

[0097] Corresponding to the control method of the I production equipment provided in the above several embodiments, an embodiment of the present application further provides a 131 control device for the I production equipment. Since the 131 control device for the I production equipment provided in the embodiments of the present application corresponds to the control method of the I production equipment provided in the above several embodiments, therefore 131 the implementation manner of the control method of the I production equipment is also applicable to the 131 control device for the I production equipment in this embodiment, and will not be described in detail in this embodiment. 131 131

[0098] Figure 6 It is a schematic structural diagram of a 131 control device for the I production equipment according to an embodiment of the present application.

[0099] As Figure 6 shown, the 131 control device 600 for the I production equipment includes: a first determination module 601, a second determination module 602, a third determination module 603, a fourth determination module 604, and a control module 605, where:

[0100] The first determination module 601 is configured to, when it is determined that 131 the TeO2 target in the I production equipment is irradiated with thermal neutrons at a thermal neutron fluence rate of , determine, according to the 130 enrichment degree of Te in the TeO2 target, the first number of nucleons N1(0) of Te in 1 gram of the TeO2 target at the initial moment. 130 in the TeO2 target 130 130 in the TeO2 target 130

[0101] The second determination module 602 is configured to determine, according to the thermal neutron fluence rate and the first number of nucleons N1(0), the first moment corresponding to when the growth rate of the specific activity of the generated 30 I during the irradiation of the TeO2 target is less than a preset growth rate, and determine, according to the first moment and the initial moment, 131 the irradiation duration of the TeO2 target irradiation, where 130 Te is irradiated with thermal neutrons to generate 130 Te, and 131 Te decays to 131 I through β decay, 131 and 131 I is irradiated with thermal neutrons to generate 132 I.

[0102] ​​​​The third determination module 603 is configured to determine, according to the thermal neutron fluence rate and the first number of nucleons N1(0), 131 Te, 131 I, and 132 the number of nucleons of I at the first moment, where 132 I is 131 generated by irradiating thermal seeds.

[0103] The fourth determination module 604 is configured to determine, according to 131 the number of nucleons of Te at the first moment, 131 the number of nucleons of I at the first moment, and 132 the number of nucleons of I at the first moment, the target duration at the end of irradiation such that 131 the radioactivity purity of I reaches a preset purity.

[0104] The control module 605 is configured to perform irradiation control on the 30 TeO2 target according to the irradiation duration, and control the duration at the end of irradiation according to the target duration, so that 131 the I production equipment obtains 131 I with a radioactivity purity reaching the preset purity.

[0105] In an embodiment of the present application, the second determination module 602 is specifically configured to:

[0106] Determine, according to the thermal neutron fluence rate and the first number of nucleons N1(0), the first variation relationship of the specific activity of 30 I with time during the process of irradiating the 131 TeO2 target;

[0107] Determine, according to the first variation relationship, 131 the first moment corresponding to when the growth rate of the specific activity of I is less than a preset growth rate.

[0108] In an embodiment of the present application, the third determination module 603 is specifically configured to:

[0109] Determine, according to the thermal neutron fluence rate and the first number of nucleons N1(0), respectively, the variation relationships of the number of nucleons of 30 Te, 131 I, and 131 I with time during the process of irradiating the 132 TeO2 target;

[0110] Determine, according to the variation relationship of the number of nucleons of 30 Te with time during the process of irradiating the 131 TeO2 target, 131 the number of nucleons of Te at the first moment;

[0111] According to the relationship between the number of nucleons of I and time during the irradiation 30 of the TeO2 target, determine 131 the number of nucleons of I at the first moment; 131

[0112] According to the relationship between the number of nucleons of I and time during the irradiation 30 of the TeO2 target, determine 132 the number of nucleons of I at the first moment. 132

[0113] In an embodiment of the present application, the fourth determination module 604 includes:

[0114] A first determination unit for determining, according to 131 the number of nucleons of Te at the first moment and 131 the number of nucleons of I at the first moment, the third change relationship of the specific activity of I with time after the irradiation of the TeO2 target ends; 130 131 132 130 132 130

[0115] A second determination unit for determining, according to 132 the number of nucleons of I at the first moment, the fourth change relationship of the specific activity of I with time after the irradiation of the TeO2 target ends; 130 132 130 131

[0116] A third determination unit for determining, according to the third change relationship and the fourth change relationship, that 130 after the target duration when the irradiation of the TeO2 target ends, 131 the radioactive purity of I reaches the preset purity.

[0117] In an embodiment of the present application, the third determination unit is specifically configured to:

[0118] For 130 a plurality of second moments after the irradiation of the TeO2 target ends, traverse the plurality of second moments in the chronological order of the plurality of second moments. For the traversed second moment, determine, according to the third change relationship, 131 the first specific activity of I at the traversed second moment;

[0119] Determine, according to the fourth change relationship, 132 the second specific activity of I at the traversed second moment;

[0120] Determine, according to the first specific activity and the second specific activity, 131 the radioactive purity of I at the traversed second moment;

[0121] When the radioactive purity reaches the preset purity, determine the target duration according to the second moment and the first moment traversed, and end the traversal.

[0122] The control device of the production equipment provided by the embodiment of the present application 131 When determining 131 In the production equipment I, when irradiating with thermal neutrons at a thermal neutron fluence rate of 130 TeO2 target, according to 130 In the TeO2 target 130 The enrichment of Te, determine the first number of nucleons N1(0) of 1 gram of 130 in the TeO2 target 130 Te, and according to the thermal neutron fluence rate and the first number of nucleons N1(0), determine the first moment corresponding to when the growth rate of the specific activity of 30 I generated during the irradiation of the TeO2 target is less than the preset growth rate, and according to the first moment and the initial moment, determine 131 the irradiation duration of the TeO2 target, and according to the thermal neutron fluence rate 130 and the first number of nucleons N1(0), determine the number of nucleons of 131 Te, 131 I and 132 I at the first moment, and according to 131 Te, 131 I and 132 I at the first moment, after determining the target duration of the end of irradiation 131 the radioactive purity of I reaches the preset purity, and according to the irradiation duration, control the 30 TeO2 target for irradiation, and control the end time of irradiation according to the target duration, so that 131 the production equipment of I obtains 131 I with a radioactive purity reaching the preset purity. Thus, according to the determined irradiation duration and target duration, the control of the 131 production equipment of I is accurately realized, so that 131 the production equipment of I can obtain 131 I with a radioactive purity reaching the preset purity.

[0123] According to the embodiment of the present application, the present application also provides a 131 production equipment of I.

[0124] Figure 7 is the structural block diagram of the 131 production equipment of I according to an embodiment of the present application.

[0125] As Figure 7 shown, this131 The I production device 700 includes: a memory 710, a processor 720, and computer instructions stored on the memory 710 and executable on the processor 720.

[0126] When the processor 720 executes the instructions, it implements the 131 control method of the I production device provided in the above embodiments.

[0127] Furthermore, 131 the I production device 700 further includes:

[0128] a communication interface 730 for communication between the memory 710 and the processor 720.

[0129] The memory 710 is used to store computer instructions executable on the processor 720.

[0130] The memory 710 may include a high-speed RAM memory and may also include non-volatile memory, such as at least one disk memory.

[0131] The processor 720 is used to implement the 131 control method of the I production device when executing the program.

[0132] If the memory 710, the processor 720, and the communication interface 730 are implemented independently, the communication interface 730, the memory 710, and the processor 720 can be interconnected through a bus and communicate with each other. The bus can be an Industry Standard Architecture (ISA) bus, a Peripheral Component Interconnect (PCI) bus, an Extended Industry Standard Architecture (EISA) bus, etc. The bus can be divided into an address bus, a data bus, a control bus, etc. For the sake of simplicity, Figure 7 only a thick line is shown in the figure, but it does not mean that there is only one bus or one type of bus.

[0133] Optionally, in a specific implementation, if the memory 710, the processor 720, and the communication interface 730 are integrated on a single chip, the memory 710, the processor 720, and the communication interface 730 can communicate with each other through an internal interface.

[0134] The processor 720 may be a Central Processing Unit (CPU), or an Application Specific Integrated Circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of the present application.

[0135] Another embodiment of the present application provides a computer-readable storage medium, on which a computer program is stored. When the program is executed by a processor, it implements the 131 control method of the I production equipment.

[0136] Another embodiment of the present application provides a computer program product, including a computer program. When the computer program is executed by a processor, it implements the 131 control method of the I production equipment.

[0137] In the description of this specification, the descriptions with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, without conflict, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0138] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present application, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically and clearly defined.

[0139] Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present application. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present application.

Claims

1. A 131 control method for an I production device, characterized in that The method includes: When determining 131 thermal neutron fluence rate thermal neutron irradiation of the I production equipment 130 in the case of a TeO2 target, according to the 130 enrichment of Te in the TeO2 target 130 determine the first number of nucleons N1(0) of Te in 1 gram of the 130 TeO2 target at the initial moment; 130 ​ According to the thermal neutron fluence rate and the first nucleon number N1(0), determine the 30 growth rate of the specific activity of 131 I generated during the irradiation of the 130 TeO2 target is less than a preset growth rate, and the corresponding first moment is determined. According to the first moment and the initial moment, determine the 130 irradiation duration of the TeO2 target, where the first moment is the moment when the irradiation of the 130 TeO2 target ends; According to the thermal neutron fluence rate and the first nucleon number N1(0), determine 131 the nucleon numbers of Te, the 131 I and 132 I at the first moment, where 130 Te is irradiated by thermal neutrons to generate 131 Te, and the 131 Te decays by β to 131 I, and the 131 I is irradiated by thermal neutrons to generate 132 I; According to the 131 number of nuclei of Te at the first moment, the 131 number of nuclei of I at the first moment, and the 132 number of nuclei of I at the first moment, after determining the target duration of the end of irradiation, the 131 radioactive purity of I reaches a preset purity; According to the irradiation duration, irradiate and control the 30 TeO2 target, and control the duration when the irradiation ends according to the target duration, so that the 131 I production equipment obtains 131 I with a radioactive purity reaching the preset purity.

2. The method according to claim 1, characterized in that, The first moment corresponding to the growth rate of the specific activity of I being less than a preset growth rate during the process of irradiating the 30 TeO2 target, determined according to the thermal neutron fluence rate 131 and the first nucleon number N1(0), includes: According to the thermal neutron fluence rate and the first nucleon number N1(0), determine the first variation relationship of the specific activity of 30 I with time during the irradiation of the 131 TeO2 target; Determine the 131 first moment corresponding to when the growth rate of the specific activity of I is less than the preset growth rate.

3. The method according to claim 1, characterized in that According to the thermal neutron fluence rate and the first nucleon number N1(0), determine the 131 Te, the 131 I, and 132 the nucleon numbers of I at the first moment, including: According to the thermal neutron fluence rate and the first nucleon number N1(0), respectively determine the 30 during the irradiation of the 131 Te, the 131 I and the 132 relationship between the nucleon numbers of I and time; According to the relationship of the number of nucleons of 30 Te changing with time during the process of irradiating the 131 TeO2 target, determine the number of nucleons of 131 Te at the first moment; According to the relationship of the number of nucleons of 30 I varying with time during the process of irradiating the 131 TeO2 target, determine the number of nucleons of 131 I at the first moment; According to the relationship between the nucleon number of 30 I and time during the process of irradiating the 132 TeO2 target, determine the nucleon number of 132 I at the first moment.

4. The method according to claim 1, wherein The method according to the 131 number of nuclei of Te at the first moment, the 131 number of nuclei of I at the first moment, and the 132 number of nuclei of I at the first moment, after determining the target duration of the end of irradiation, the 131 radioactive purity of I reaches a preset purity, including: Based on the 131 number of nuclei of Te at the first moment and the 131 number of nuclei of I at the first moment, determine the 130 third variation relationship of the specific activity of I with time after the irradiation of the 131 TeO2 target is completed; Based on the number of nuclei of 132 I at the first moment, determine the 130 specific activity of 132 I changes with time after the irradiation of the TeO2 target is completed; Based on the third variation relationship and the fourth variation relationship, determine the 130 target duration after the irradiation of the TeO2 target is completed, and then the 131 radioactive purity of I reaches the preset purity.

5. The method according to claim 4, wherein Determining the 130 target duration after the irradiation of the TeO2 target is completed, and then 131 the radioactive purity of I reaches a preset purity, including: For 130 At multiple second moments after the irradiation of the TeO2 target is completed, traverse the multiple second moments in the chronological order of the time of the multiple second moments. For the traversed second moment, determine the 131 First specific activity of I at the traversed second moment; Determine the 132 second specific activity of I at the traversed second moment according to the fourth variation relationship; Determine the 131 radioactive purity of I at the traversed second moment according to the first specific activity and the second specific activity; When the radioactive purity reaches a preset purity, determine the target duration according to the traversed second moment and the first moment, and end the traversal.

6. A 131 control device for an I production equipment, characterized in that The device includes: The first determination module is configured to determine, when 131 thermal neutron irradiation of the TeO2 target in the I production equipment at a thermal neutron fluence rate is carried out, according to the 130 enrichment degree of Te in the TeO2 target, determine the first number of nucleons N1(0) of Te in 1 gram of the 130 TeO2 target at the initial moment; 130 Te in the TeO2 target, determine the first number of nucleons N1(0) of Te in 1 gram of the 130 TeO2 target at the initial moment; 130 Te; A second determination module, configured to determine, according to the thermal neutron fluence rate and the first nucleon number N1(0), a first moment corresponding to a growth rate of the specific activity of 30 I generated during the irradiation of the 131 TeO2 target being less than a preset growth rate, and determine the irradiation duration of the 130 TeO2 target irradiation according to the first moment and the initial moment, where 130 Te is irradiated by thermal neutrons to generate 131 Te, and the 131 Te decays by β to 131 I, and the 131 I is irradiated by thermal neutrons to generate 132 I; A third determination module, configured to determine the number of nucleons of the Te, the 131 I, and the 131 I at the first moment according to the thermal neutron fluence rate and the number of nucleons N1(0) of the first nucleon, where the 132 I is generated by irradiating the heat seeds by the 132 I; 131 I is generated by irradiating the heat seeds by the A fourth determination module, configured to determine, according to the number of nucleons of 131 Te at the first moment, the number of nucleons of 131 I at the first moment, and the number of nucleons of 132 I at the first moment, the target duration after the irradiation ends when the 131 radioactive purity of I reaches a preset purity; The control module is used to perform irradiation control on the 30 TeO2 target according to the irradiation duration, and control the duration of the end of irradiation according to the target duration, so that the 131 I production equipment obtains 131 I with a radioactive purity reaching the preset purity.

7. The device according to claim 6, characterized in that, The second determination module is specifically configured to: According to the thermal neutron fluence rate and the first nucleon number N1(0), determine the first variation relationship of the specific activity of 30 I with time during the irradiation of the 131 TeO2 target Determine the 131 first moment corresponding to when the growth rate of the specific activity of I is less than a preset growth rate according to the first variation relationship.

8. The device according to claim 6, characterized in that, The third determination module is specifically configured to: According to the thermal neutron fluence rate and the first nucleon number N1(0), respectively determine the 30 during the irradiation of the 131 Te, the 131 I and the 132 relationship between the nucleon numbers of I and time; According to the relationship between the number of nucleons of 30 Te during the process of irradiating the 131 TeO2 target as a function of time, determine the 131 number of nucleons of Te at the first moment; According to the variation relationship of the number of nucleons of 30 I with time during the process of irradiating the 131 TeO2 target, determine the number of nucleons of 131 I at the first moment; According to the change relationship of the number of nucleons of 30 I with time during the process of irradiating the 132 TeO2 target, determine the number of nucleons of 132 I at the first moment.

9. The device according to claim 6, characterized in that The fourth determination module includes: A first determination unit, configured to determine, according to the number of nucleons of 131 Te at the first moment and the number of nucleons of 131 I at the first moment, a third variation relationship of the specific activity of 130 I with time after the irradiation of the 131 TeO2 target is completed; A second determination unit, configured to determine, according to the number of nucleons of 132 I at the first moment, a fourth variation relationship of the specific activity of 130 I with respect to time after the irradiation of the 132 TeO2 target is completed; A third determination unit, configured to determine, according to the third variation relationship and the fourth variation relationship, the 130 target duration after the irradiation of the TeO2 target is ended, and then 131 the radioactive purity of I reaches a preset purity.

10. The device according to claim 9, characterized in that, The third determination unit is specifically configured to: For 130 At multiple second moments after the irradiation of the TeO2 target is completed, traversing the multiple second moments in the chronological order of the time of the multiple second moments, for the traversed second moment, according to the third change relationship, determining the 131 First specific activity of I at the traversed second moment; Determine the 132 second specific activity of I at the second moment in time when traversing; Based on the first specific activity and the second specific activity, determine the 131 radioactive purity of I at the traversed second moment; When the radioactive purity reaches a preset purity, determine the target duration according to the traversed second moment and the first moment, and end the traversal.

11. A 131 production device, characterized in that It includes: A memory, a processor, and a computer program stored on the memory and executable on the processor, wherein when the processor executes the computer program, the method described in any one of claims 1-5 is implemented.

12. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by the processor, the method described in any one of claims 1-5 is implemented.

13. A computer program product, characterized in that, It includes a computer program, and when the computer program is executed by the processor, the method described in any one of claims 1-5 is implemented.

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