Health-care beverage capable of improving sleep, expelling toxins, clearing damp and improving immunity and preparation method of health-care beverage

Abstract

The invention discloses a health-care beverage capable of improving sleep, expelling toxins, clearing damp and improving immunity and a preparation method of the health-care beverage. , lalang grass rhizome, isatis root and pine needle; auxiliary materials; the traditional Chinese medicine composition is prepared from poria cocos, radix puerariae, pericarpium citri reticulatae, hawthorn, corn stigma, liquorice, astragalus membranaceus, mint, folium mori, honeysuckle and flos chrysanthemi indici. A functional additive; the invention also discloses a preparation method of the sugar-free sweetener. The invention relates to the technical field of health-care drinks. According to the health-care beverage capable of improving sleep, expelling toxins, clearing damp and improving immunity and the preparation method of the health-care beverage, through material replacement, process innovation and function integration, the problems of high cost, single effect, easy loss of active ingredients and the like in the prior art are solved, and the health-care beverage has multiple effects of clearing damp, helping sleep, regulating immunity and the like, and is suitable for daily conditioning of sub-health people.

Description

Technical Field

[0001] The invention relates to the technical field of health drinks, in particular to a health drink capable of improving sleep, removing toxins, removing dampness and improving immunity and a preparation method thereof. Background Art

[0002] In modern society, excessive moisture, sleep disorders and low immunity have become common health problems. Moisture is mostly caused by a humid environment, greasy or cold food, causing symptoms such as heaviness, fatigue, and edema; while fast-paced life and increased stress exacerbate insomnia, anxiety and other problems. In the prior art, health drinks for removing moisture and aiding sleep mostly rely on a single Chinese herbal ingredient (such as Radix Pseudostellariae and Radix Bupleuri) or a complex formula, which has the following shortcomings; High cost: Some products use precious medicinal materials (such as ginseng and American ginseng), which are difficult to produce on a large scale.

[0003] Inefficient process: The traditional decoction method has a low extraction rate of active ingredients (only 60%-75%), and high-temperature and long-term sterilization can easily destroy heat-sensitive substances.

[0004] Single function: Most products only focus on removing dampness or aiding sleep, and lack comprehensive conditioning effects.

[0005] Limitations of applicability: The formula does not take into account differences in physical constitution and may cause side effects (for example, people with weak spleen and stomach are prone to diarrhea after drinking lotus leaf tea). Summary of the invention

[0006] In view of the deficiencies in the prior art, the present invention provides a health drink that improves sleep, detoxifies, removes dampness and improves immunity, and a preparation method thereof, which solves the problems of high cost, inefficient process, single function and limited applicability.

[0007] To achieve the above objectives, the present invention is implemented through the following technical scheme: a health drink for improving sleep, detoxifying, removing dampness and improving immunity, comprising the following components by weight: Main ingredients: Imperata root, Isatis root, pine needles; Auxiliary materials: Poria, Pueraria root, tangerine peel, hawthorn, corn silk, licorice, astragalus, mint, mulberry leaf, honeysuckle, wild chrysanthemum; Functional additives: nano-grade gypsum, erythritol.

[0008] Preferably, the composition comprises the following raw materials in parts by weight: 60-200 parts of Imperata root, 50-100 parts of Isatis root, 60-200 parts of pine needles, 14-40 parts of Poria cocos, 10-30 parts of Pueraria root, 10-25 parts of dried tangerine peel, 5-20 parts of hawthorn, 5-15 parts of corn silk, 15-30 parts of licorice, 15-30 parts of astragalus, 15-25 parts of mint, 15-25 parts of mulberry leaves, 10-20 parts of honeysuckle, 10-20 parts of wild chrysanthemum, 5-15 parts of nano-gypsum, and 5-15 parts of erythritol.

[0009] Preferably, the nanoscale gypsum is calcium sulfate hydrate, and its particle size after ball milling is ≤100 nm, which is used for nano-crystalline embedding of active ingredients.

[0010] Preferably, Poria cocos, Pueraria lobata, and Citrus reticulata in the adjuvant are all dried in the sun and then crushed to 80-120 meshes, and Hawthorn and Corn silk are dried at low temperature (50-60 °C) and then crushed to 60-100 meshes.

[0011] The present invention also discloses a preparation method of a health drink for improving sleep, expelling dampness and toxins, and enhancing immunity, which specifically includes the following steps: S1. Material pretreatment; Group A (fresh pine needles, fresh Imperata cylindrica) is broken after ultrasonic cleaning; Group B (Isatis indigotica, Poria cocos) and Group C (Glycyrrhiza uralensis, Astragalus membranaceus, Pueraria lobata) are respectively soaked for 45 minutes and enzymolyzed with cellulase (50 °C, pH 5.0) for 1 hour; Group D (Lonicera japonica, Chrysanthemum indicum, Corn silk) and Group E (Mentha haplocalyx, Morus alba, Hawthorn, Citrus reticulata) are respectively soaked for 30 minutes and broken; S2. Gradient temperature-controlled extraction; Group A is dynamically extracted at 80 °C for 1 hour; Groups B and C are added, and the temperature is raised to 95 °C for extraction for 30 minutes; Groups D and E are added, and the extraction is cycled at 90 °C for 40 minutes; S3. Vacuum concentration and nano-crystallization; The extraction solution is vacuum concentrated (60 °C, -0.08 MPa) to 1 / 3 of the original volume; Nano-scale gypsum and erythritol are added, and stirred at 85 °C for 45 minutes to form nano-crystals; S4. Sterilization and filling; Ultra-high temperature instantaneous sterilization (135 °C, 5 seconds) is adopted, and it is cooled to 85-90 °C for aseptic filling.

[0012] Preferably, during the gradient temperature-controlled extraction process, a dynamic circulation system is adopted in each stage, and the flow rate is controlled at 1.5-2.0 L / min.

[0013] Preferably, in the nano-crystalline embedding process, the mass ratio of nano-scale gypsum to erythritol is 1:1 - 1:2.

[0014] Preferably, the final product is a clear liquid, with a pH value of 5.5-6.5, a soluble solid content ≥15%, and an active ingredient retention rate ≥90%.

[0015] Preferably, the functions of the drink include: improving sleep quality (through the synergistic effect of the resin in pine needles and the triterpenoids in Poria cocos); detoxifying and removing dampness (the synergistic effect of corn silk and Imperata cylindrica enhances diuretic function); enhancing immunity (puerarin and astragalus polysaccharide form a composite synergistic system).

[0016] Preferably, it is suitable for sub-healthy people, those with heavy dampness and low immunity. Drinking 30 - 50 ml per day for 14 consecutive days can significantly improve related symptoms.

[0017] The present invention provides a health drink for improving sleep, detoxifying and removing dampness, and enhancing immunity, and a preparation method thereof. Compared with the prior art, it has the following beneficial effects: 1. The health drink for improving sleep, detoxifying and removing dampness, and enhancing immunity and its preparation method solve the problems of high cost, single efficacy, and easy loss of active ingredients in the prior art, and have multiple effects such as removing dampness, assisting sleep, and immune regulation, and are suitable for the daily conditioning of sub-healthy people. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is the overall preparation process flow chart of the health drink of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the protection scope of the present invention.

[0020] Please refer to Figure 1 , the embodiments of the present invention provide a technical solution: a health drink for improving sleep, detoxifying and removing dampness, and enhancing immunity, which includes the following components by weight:

[0021] Further, the composition includes the following raw materials by weight: 60 - 200 parts of Imperata cylindrica, 50 - 100 parts of Isatis tinctoria, 60 - 200 parts of pine needles, 14 - 40 parts of Poria cocos, 10 - 30 parts of Pueraria lobata, 10 - 25 parts of Citrus reticulata Blanco, 5 - 20 parts of Crataegus pinnatifida, 5 - 15 parts of corn silk, 15 - 30 parts of Glycyrrhiza uralensis Fisch, 15 - 30 parts of Astragalus membranaceus (Fisch.) Bunge, 15 - 25 parts of Mentha haplocalyx Briq, 15 - 25 parts of Morus alba L, 10 - 20 parts of Lonicera japonica Thunb, 10 - 20 parts of Chrysanthemum indicum L, 5 - 15 parts of nano - gypsum fibrosum, 5 - 15 parts of erythritol.

[0022] Among them, the functions of each raw material are as follows: 1. Imperata cylindrica, alias: Hair Root, Imperata Root, White Cogongrass, Silk Cogongrass, Cogongrass, White Cogongrass Root, Earth Pipe, Root of Manyleaf Houttuynia, Blue Root, etc. Generally, it is 25 - 80 cm long and 2 - 5 mm in diameter. The surface is yellowish white or light yellow, shiny, with longitudinal wrinkles, obvious nodes, grayish brown scale leaves and fine roots remaining on the nodes. The internode length is 1 - 5 cm. It is light in weight and tough in texture. The fracture surface is fibrous, yellowish white, with many radial fissures. Sometimes, a small hole can be seen in the center. Imperata cylindrica contains arundoin, coixol, anemonin, β-sitosterol, glucose, fructose, xylose, citric acid, oxalic acid, malic acid, potassium element, etc., and has the effects of clearing heat and detoxifying, nourishing the stomach and diuresis, tonifying the middle qi, treating cough due to lung heat, and restoring liver function. After removing the surface impurities, select the fresh, thick, long, white, and sweet ones for bubble surf cleaning and set aside for use.

[0023] 2. Isatis indigotica, alias: Woad, Mountain Blue, Big Indigo Root, Indigo Root of Baphicacanthus cusia Bremek., Blue Dragon Root, Earth Dragon Root, Big Indigo, etc. The common varieties include Isatis indigotica, Baphicacanthus cusia Bremek., Baphicacanthus cusia Bremek. var. microcarpa, Isatis costata, Isatis tinctoria. Isatis indigotica contains various amino acids such as plant protein and trace elements, and has the effects of clearing heat and detoxifying and treating febrile diseases and infectious diseases. Select the fresh, straight, firm, powdery, and thick ones and clean them by bubble surf cleaning for use. 3. Pine needles are from high-quality pine tree leaves such as Pinus massoniana, Pinus koraiensis, Pinus thunbergii, Pinus elliottii, Pinus taiwanensis, Pinus densiflora, Pinus armandii, Pinus bungeana, Pinus tabuliformis, Pinus wallichiana, Cedrus deodara, Podocarpus macrophyllus, Pinus bungeana, Pinus parviflora, Pinus pumila, Pinus koraiensis. Pine needles contain: β-carotene, vitamin C, vitamin E, protein, amino acids, and trace elements calcium, iron, zinc, selenium, and rich pine resin, etc., and have the effects of calming the nerves and nourishing the brain, dredging the meridians and activating collaterals, reducing high blood pressure, high blood sugar, and high blood lipid, slowing down aging, enhancing human immunity, dispelling pestilence and preventing wind, and anti-corrosion. Generally, select the fresh pine leaves between 4 - 8 meters of pine trees over 10 years old and over 10 meters high, remove the impurities, and clean them by bubble surf cleaning for use.

[0024] 4. Poria cocos is a traditional Chinese medicine for promoting diuresis and excreting dampness, belonging to the family Polyporaceae. It has functions such as strengthening the spleen, calming the nerves, and tranquilizing the mind, and is usually used to treat dysuria, vomiting, cough with copious phlegm, insomnia and amnesia, etc. Poria cocos is a common traditional Chinese medicine. It mainly contains polysaccharides, sterols, fats, proteins, adenine, etc., and is in the shape of oval, spherical or irregular small pieces with different sizes. The outer skin is mostly brown, thin and rough. In traditional food culture, when Poria cocos is made into pancakes with white flour, it can treat diabetes, overeating and indigestion, and obesity; when cooked with red dates, red beans, rock sugar, etc. into porridge, it can treat insomnia and amnesia; when cooked with crucian carp into soup, it can treat edema. In modern medicine, when Poria cocos is made into compound preparations with other Chinese herbal medicines, such as Cinnamon Twig and Poria Pill, Ginseng, Atractylodes Macrocephala, and Amomum Villosum Pill for Stomach and Poria, etc., it can treat patients with blood stasis amenorrhea, spleen deficiency, dysuria, etc.

[0025] 5. Kudzu Root (Latin name: Puerariae Lobatae Radix), a traditional Chinese medicine name, is the dried root of Pueraria lobata (Willd.) Ohwi, a plant of the genus Pueraria in the legume family. It is a stout vine that can grow up to 8 m long. The whole plant is covered with long yellow stiff hairs. The base of the stem is woody and has thick and massive roots. The pinnate compound leaf has 3 leaflets; the stipules are adnate, ovate-oblong, with lines; the stipels are linear-lanceolate, equal to or longer than the petiolules; the leaflets are trilobed, occasionally entire, the terminal leaflet is broadly ovate or obliquely ovate, 8 - 15 (-19) cm long, 5 - 12 (-18) cm wide, with a long acuminate apex, the lateral leaflets are obliquely ovate, slightly smaller, with sparse pubescence that is light yellow and appressed on the upper surface and denser on the lower surface; the petiolules are covered with yellowish-brown villi. The pod is oblong, 5 - 9 cm long, 8 - 11 mm wide, flat, and covered with brown long stiff hairs. The flowering period is from September to October, and the fruiting period is from November to December. It has the effects of relieving muscle fever, promoting eruption, promoting fluid production to quench thirst, and raising yang to stop diarrhea. It is mainly used to treat exterior syndrome fever, stiffness and pain in the nape and back, unsmooth measles, thirst in febrile diseases, yin deficiency and polydipsia, diabetes, heat diarrhea, and spleen deficiency diarrhea.

[0026] 6. Tangerine Peel, a traditional Chinese medicine name. It is the dried mature pericarp of Citrus reticulata Blanco and its cultivated varieties in the Rutaceae family. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and is mainly used to treat qi stagnation syndrome of the spleen and stomach, vomiting, hiccups, damp phlegm, cold phlegm cough, and chest impediment.

[0027] 7. Hawthorn (Latin scientific name: Crataegus pinnatifida Bge.), a deciduous tree belonging to the genus Crataegus in the Rosaceae family, with other names including Chinese hawthorn, red fruit, Japanese kerria, green pear, etc. The hawthorn tree can reach a height of 6 meters. The bark is dark gray or grayish-brown, and the edges of the leaves have irregular serrations. The petals of the hawthorn are white, and the fruits are dark red. Hawthorn often grows on the edges of mountain forests or in thickets. It is a sun-loving tree species, liking light, cool and humid environments, being cold-resistant and heat-resistant, and having strong adaptability. It generally blooms from May to June, and the fruits mature from September to October. The hawthorn kernel is hard, the flesh is thin, and it tastes slightly sour and astringent. It is rich in various nutrients and has certain nutritional value. Both the mature fruits and flowers can be eaten and used as medicine. The fruits are generally eaten raw or made into fruit preserves and cakes. After drying, they can be used as medicine, having the effects of reducing blood lipid, blood pressure, strengthening the heart, and anti-arrhythmia. At the same time, it is also a good medicine for strengthening the spleen and promoting digestion, promoting digestion and resolving stagnation, activating blood circulation and resolving phlegm, and has good curative effects on symptoms such as fullness in the chest and diaphragm, hernia, blood stasis, and amenorrhea.

[0028] 8. Corn silk, also known as dragon's beard, is a traditional Chinese medicine and a plant of the genus Zea mays in the Gramineae family. Corn silk is a filamentous, smooth and soft fiber, which comes from the styles and stigmas of corn. Each fiber is formed by the elongation of the stigma, and the bottom is connected to an ovule. When mature, it can grow up to 30 cm or longer, and the color is light green or yellowish-brown. It is collected when the fruits are mature in summer and autumn, and the impurities are removed. It can be used fresh or dried for raw use. Corn silk contains various functional components such as flavonoids, polysaccharides, and saponins, and has a wide range of preventive and health care effects in regulating blood lipids, blood sugar, etc.

[0029] 9. Nano-sized raw gypsum, also known as stone paste, white tiger, raw gypsum, calcined gypsum, fine stone, fine-grained marble, soft gypsum, cold water stone, calcined gypsum, etc., is a hydrate of calcium sulfate and has a catalyst function. Take the raw gypsum Chinese medicinal material that is bright white, crystalline, in strip or irregular block shape, white, grayish-white or light yellow, translucent, heavy in weight, soft in texture, with a silky luster on the longitudinal section, odorless, and tasteless.

[0030] 10. Erythritol, also known as protoalcohol and erythritol, has the chemical name of 1,2,3,4-butanetetraol and is the smallest molecular weight sugar alcohol found in nature. Its chemical structure is C4H10O4, with a relative molecular weight of 122.12. It is a white, odorless, heat-stable crystal. It is slightly sweet, has a strong cooling sensation, and its sweetness is 60% - 80% of that of sucrose. It has a low calorific value, about one-tenth of that of sucrose. It is stable to heat and has low hygroscopicity. It is easily soluble in water, slightly soluble in ethanol, and insoluble in ether. Its melting point is 119 - 123 degrees Celsius. There are mainly two methods for the production of erythritol, one is the fermentation method, and the other is the synthesis method. It has the characteristics of low calorific value, high safety, safe to eat, and not being metabolized and absorbed by the human body, and can be used as an ideal sweetener.

[0031] 11. Licorice is a commonly used Chinese medicinal material for reconciling various medicines. It mainly contains flavonoids, polysaccharides, triterpenoids, etc., and has the effects of purging fire and detoxifying, moistening the lungs and reducing phlegm, tonifying the five internal organs, anti-inflammatory and analgesic, calming the nerves and soothing the soul, etc. Select the dried licorice that is firm and heavy in texture, slightly sunken in the center of the end cut surface, slightly fibrous, rich in powder, with radial texture, cracks, an obvious ring pattern and chrysanthemum heart on the cross section, obvious layer ring pattern, fragrant smell, and sweet taste for use.

[0032] 12. The root of Astragalus membranaceus is a well-known traditional Chinese medicine, containing rich amino acids and flavonoids, as well as components such as astragalus saponins, astragalus polysaccharides, alkaloids, organic acids, and trace elements such as iron, manganese, zinc, selenium, chromium, carotene, folic acid, β-sitosterol, linoleic acid, linolenic acid, riboflavin, vitamin P, etc. It has the effects of promoting secretion, invigorating the spleen and replenishing qi, anti-tumor, reducing blood lipids, reducing blood sugar, protecting the cardiovascular system, treating Helicobacter pylori infection, gastric ulcer and urticaria. Select the raw materials that are cylindrical, slightly twisted, 15 - 70 cm long, with thick and long strips, few wrinkles, firm and cottony texture, rich in powder, and sweet taste for use.

[0033] 13. The edible nutritional value of peppermint leaves is particularly high. The main components include menthol, menthone, glucoside, various free amino acids, and various flavonoid compounds, etc. It has the effects of sterilizing and relieving itching, analgesic and cough-relieving, resisting viruses, and enhancing resistance. Select the dried raw materials in the market for use.

[0034] 14. Mulberry leaves contain extremely high flavonoids, alkaloids, phytosterols, proteins, amino acids, and mulberry leaf polysaccharides, etc. It has the effects of reducing blood lipid, blood pressure, blood sugar, cholesterol, anti-thrombosis, antibacterial and anti-inflammatory. Select the dried raw materials in the market for use.

[0035] 15. Honeysuckle mainly contains inositol, flavonoids, inositol, saponins, tannins, flavonol in leaves, saponins in stems, etc. It has the effects of clearing heat and detoxifying, sterilizing and anti-inflammatory, anti-influenza virus, enhancing the phagocytic function of white blood cells, and treating diseases such as sore throat, bacillary dysentery, and enteritis. Select the dried raw materials in the market for use.

[0036] 16. Wild chrysanthemum mainly contains chrysanthemin, vitamin A, vitamin B1, chrysanthenone, borneol, bornyl acetate, etc.; it has the effects of dispelling wind and dissipating heat, calming the liver and detoxifying, anti-inflammatory and anti-toxic, can significantly dilate the coronary artery, enhance the resistance of capillaries and the effect of anti-virus. Select the dried raw materials in the market for use.

[0037] A preparation method of a health care drink for improving sleep, expelling dampness and detoxifying, and enhancing immunity specifically includes the following steps: Example 1 (optimal proportion type) 1. Raw material ratio (parts by weight) 80 parts of Imperata cylindrica, 60 parts of Isatis tinctoria, 80 parts of pine needles (fresh leaves of Pinus massoniana, tree age 12 years, picking height 5 meters), 25 parts of Poria cocos, 20 parts of Glycyrrhiza uralensis, 20 parts of Astragalus membranaceus, 15 parts of Pueraria lobata, 15 parts of Citrus reticulata Blanco, 20 parts of peppermint, 20 parts of mulberry leaves, 15 parts of honeysuckle, 15 parts of wild chrysanthemum, 10 parts of corn silk, 8 parts of nano-sized gypsum (particle size ≤ 100nm), 10 parts of erythritol.

[0038] 2. Preparation steps Raw material pretreatment Group A (fresh pine needles, fresh Imperata cylindrica): The fresh pine needles and fresh Imperata cylindrica are cleaned by an ultrasonic cleaner (frequency 40kHz, power 300W) for 15 minutes to remove surface impurities, and crushed to a particle size ≤ 2mm for standby.

[0039] Group B (Isatis tinctoria, Poria cocos), Group C (Glycyrrhiza uralensis, Astragalus membranaceus, Pueraria lobata, Citrus reticulata Blanco): Soak separately in pure water (material-liquid ratio 1:10) for 45 minutes, add cellulase (enzyme activity 5000U / g, addition amount 0.5%), enzymatically hydrolyze at 50°C and pH 5.0 for 1 hour, and break to 80 mesh after enzymatic hydrolysis for standby.

[0040] Group D (honeysuckle, wild chrysanthemum, corn silk), Group E (mint, mulberry leaf, hawthorn): Soak in pure water (material-liquid ratio 1:8) for 30 minutes, dry at low temperature (55°C) and then pulverize to 60 mesh for standby.

[0041] Gradient temperature-controlled dynamic extraction The first stage (volatile oil extraction): Put Group A into the extraction tank and add pure water (material-liquid ratio 1:12); keep warm at 80°C for 1 hour, and the dynamic circulation flow rate is 1.8 L / min; Data support: The extraction rate of volatile oil ≥ 85% (detected by GC-MS).

[0042] The second stage (polysaccharide and flavonoid extraction): Add Group B and Group C, raise the temperature to 95°C, and keep warm for 30 minutes; Data support: The polysaccharide yield is increased to 12.3% (phenol-sulfuric acid method), and the flavonoid content reaches 8.5 mg / g (ultraviolet spectrophotometry).

[0043] The third stage (extraction of comprehensive active substances): Add Group D and Group E, and circulate and extract at 90°C for 40 minutes; Data support: The total phenol content reaches 25 mg / g (Folin-Ciocalteu method), and the retention rate of chlorogenic acid ≥ 92% (detected by HPLC).

[0044] Negative pressure concentration and nanocrystallization The extraction solution is concentrated to 1 / 3 of the original volume by a vacuum concentration system (60°C, pressure -0.08 MPa); add nanoscale gypsum and erythritol (mass ratio 1:1.5), and stir at 85°C for 45 minutes; Data support: The particle size of nanocrystals ≤ 150 nm (analyzed by dynamic light scattering), and the embedding rate of active ingredients ≥ 95%.

[0045] Sterilization and filling Adopt ultra-high temperature instantaneous sterilization (UHT, 135°C, 5 seconds); after cooling to 88°C, fill into PET bottles aseptically; Data support: The microbial indicators after sterilization meet GB7101-2022, and the retention rate of active ingredients ≥ 90%.

[0046] Data demonstration Extraction rate of active ingredients: Pine needle volatile oil: The extraction rate shown by GC-MS detection is 85.3% (only 65% by traditional water extraction method); Astragalus polysaccharide: The content determined by the phenol-sulfuric acid method is 12.8 mg / g (the content of the control group without enzymatic hydrolysis process is 8.2 mg / g); Retention rate of chlorogenic acid: The detection by HPLC reaches 93.5% (only 75% after traditional high-temperature sterilization).

[0047] Microbial indicators: Total number of colonies ≤ 50 CFU / ml (GB7101-2022 requires ≤ 100 CFU / ml); Escherichia coli and Salmonella are not detected.

[0048] Stability test: Accelerated test (40 °C, RH75%): The retention rate of active ingredients is ≥ 89% within 18 months, and there is no precipitation or stratification.

[0049] Human trial: 60 insomnia subjects drink 40 ml daily. After 14 days: The sleep onset time is shortened by 38% (the control group is shortened by 12%); The sleep quality score is increased by 4.2 points (full score is 10 points, and the control group is increased by 1.5 points).

[0050] Example 2 (low-cost light formula) 1. Raw material ratio (parts by weight) 50 parts of Imperata cylindrica, 40 parts of Isatis tinctoria, 50 parts of Pinus elliottii needles (fresh leaves of Pinus elliottii), 15 parts of Poria cocos, 10 parts of Pueraria lobata, 15 parts of Citrus reticulata Blanco, 5 parts of Crataegus pinnatifida, 5 parts of Zea mays stigma, 15 parts of Glycyrrhiza glabra, 15 parts of Astragalus membranaceus, 15 parts of Mentha haplocalyx Briq., 15 parts of Morus alba L., 10 parts of Lonicera japonica Thunb., 10 parts of Chrysanthemum indicum L., 5 parts of nano-sized gypsum fibrosum, 5 parts of erythritol (particle size ≤ 100 nm).

[0051] 2. Preparation steps Raw material pretreatment Group A (fresh Pinus elliottii needles, Imperata cylindrica): Fresh Pinus elliottii needles and fresh Imperata cylindrica are ultrasonically cleaned (frequency 40 kHz, power 300 W) for 15 minutes to remove surface impurities; They are crushed to a particle size ≤ 2 mm and reserved.

[0052] Group B (Isatis tinctoria, Poria cocos), Group C (Glycyrrhiza glabra, Astragalus membranaceus, Pueraria lobata): They are respectively soaked in purified water (material-liquid ratio 1:10) for 40 minutes; Cellulase (enzyme activity 5000 U / g, addition amount 0.3%) is added, and enzymatic hydrolysis is carried out at 50 °C and pH 5.0 for 40 minutes; After enzymatic hydrolysis, they are crushed to 80 meshes and reserved.

[0053] Group D (Lonicera japonica Thunb., Chrysanthemum indicum L., Zea mays stigma), Group E (Mentha haplocalyx Briq., Morus alba L., Crataegus pinnatifida): They are soaked in purified water (material-liquid ratio 1:8) for 30 minutes; After low-temperature drying (55 °C), they are pulverized to 60 meshes and reserved.

[0054] Gradient temperature-controlled dynamic extraction The first stage (volatile oil extraction): Put Group A into the extraction tank and add pure water (material-liquid ratio 1:12). Keep it at 80°C for 1 hour with a dynamic circulation flow rate of 1.5 L / min. Data support: The volatile oil extraction rate ≥ 82% (detected by GC-MS).

[0055] The second stage (polysaccharide and flavonoid extraction): Add Group B and Group C, heat up to 90°C, and keep it warm for 20 minutes. Data support: The polysaccharide yield is increased to 10.5% (phenol-sulfuric acid method), and the flavonoid content reaches 7.2 mg / g (ultraviolet spectrophotometry).

[0056] The third stage (extraction of comprehensive active substances): Add Group D, and perform cyclic extraction at 85°C for 30 minutes. Data support: The total phenol content reaches 20 mg / g (Folin-Ciocalteu method), and the retention rate of organic acids ≥ 90% (detected by HPLC).

[0057] Negative pressure concentration and nanocrystallization The extraction solution is concentrated to 1 / 3 of the original volume by a vacuum concentration system (60°C, pressure -0.08 MPa); Add nanoscale gypsum and erythritol (mass ratio 1:1), and stir at 85°C for 45 minutes. Data support: The particle size of nanocrystals ≤ 150 nm (analyzed by dynamic light scattering), and the embedding rate of active ingredients ≥ 92%.

[0058] Sterilization and filling Ultra-high temperature instantaneous sterilization (UHT, 135°C, 5 seconds) is adopted; After cooling to 85°C, it is aseptically filled into PET bottles. Data support: The microbial indicators after sterilization meet GB7101-2022, and the retention rate of active ingredients ≥ 85%.

[0059] Data demonstration Cost comparison: The raw material cost is reduced by 27% (auxiliary material replacement and dosage optimization); The energy consumption is reduced by 20% (shortening the time of the high-temperature stage).

[0060] Retention rate of active ingredients: The puerarin content is 8.1 mg / g (9.2 mg / g in Example 1, with controllable difference); The total flavonoid retention rate is 83% (75% in the traditional process).

[0061] Efficacy verification: After 30 sub-healthy people drink it: The proportion of reduced fatigue is 80% (45% in the control group); The serum IgG level is increased by 18% (immune index).

[0062] Taste evaluation: The score of sweet and sour palatability is 8.5 / 10 (6.8 / 10 for the traditional formula); The feedback rate of no bitterness is 95%.

[0063] Example 3 (highly effective dampness-removing formula) Raw material ratio (parts by weight) 120 parts of Imperata cylindrica root, 20 parts of corn silk, 30 parts of Poria cocos, 60 parts of pine needles (fresh leaves of Pinus massoniana), 50 parts of Isatis indigotica root, 15 parts of licorice, 15 parts of Astragalus membranaceus, 10 parts of Pueraria lobata, 10 parts of tangerine peel, 15 parts of mint, 15 parts of mulberry leaves, 10 parts of honeysuckle, 10 parts of wild chrysanthemum, 10 parts of nano-level gypsum fibrosum, 8 parts of erythritol.

[0064] 2. Preparation steps Pretreatment of raw materials Group A (fresh pine needles, Imperata cylindrica root): Fresh pine needles and fresh Imperata cylindrica root are ultrasonically cleaned (frequency 40 kHz, power 300 W) for 15 minutes; crushed to a particle size of ≤2 mm and reserved.

[0065] Group B (Isatis indigotica root, Poria cocos), Group C (licorice, Astragalus membranaceus, Pueraria lobata): Soak them separately in pure water (material-liquid ratio 1:10) for 45 minutes; add cellulase (enzyme activity 5000 U / g, addition amount 0.5%), and enzymatically hydrolyze at 50 °C and pH 5.0 for 1 hour; after enzymatic hydrolysis, crush them to 80 meshes and reserve.

[0066] Group D (corn silk): Separate pre-fermentation treatment: Inoculate Lactobacillus plantarum (1×10 6 CFU / g), ferment at 37 °C for 2 hours; after fermentation, mix with honeysuckle and wild chrysanthemum, soak for 30 minutes and crush.

[0067] Group E (mint, mulberry leaves, tangerine peel): Soak in pure water (material-liquid ratio 1:8) for 30 minutes; dry at low temperature (55 °C) and then pulverize to 60 meshes and reserve.

[0068] Gradient temperature-controlled dynamic extraction The first stage (volatile oil extraction): Put Group A into the extraction tank, add pure water (material-liquid ratio 1:12); keep warm at 80 °C for 1 hour, and the dynamic circulation flow rate is 1.8 L / min; Data support: The extraction rate of pine needle volatile oil is 86.5% (detected by GC-MS).

[0069] The second stage (extraction of polysaccharides and diuretic components): Add Group B and Group C, raise the temperature to 95 °C, and keep warm for 30 minutes; Data support: The content of Poria cocos polysaccharide is 15.2 mg / g (phenol-sulfuric acid method), and the total phenol of corn silk increases by 35% after fermentation.

[0070] The third stage (comprehensive extraction): Add Group D and Group E, and perform cyclic extraction at 90 °C for 40 minutes; Data support: The content of chlorogenic acid is 9.8 mg / g (HPLC), and the potassium ion dissolution rate increases by 30%.

[0071] Negative pressure concentration and nanocrystallization The extract is concentrated to 1 / 3 of the original volume by a vacuum concentration system (60 °C, pressure -0.08 MPa); nanoscale gypsum and erythritol (mass ratio 1:1.2) are added, and stirred at 85 °C for 45 minutes; Data support: the particle size of nanocrystals ≤ 120 nm (dynamic light scattering analysis), and the embedding rate ≥ 94%.

[0072] Sterilization and filling Ultra-high temperature instantaneous sterilization (135 °C, 5 seconds); cooled to 88 °C for aseptic filling; Data support: the microbial indicators meet the national standards, and the retention rate of diuretic active ingredients ≥ 90%.

[0073] Data demonstration Diuretic experiment (rat model): urine output increased by 42% (15% in the control group); serum urea nitrogen (BUN) decreased by 25% (moisture metabolism index).

[0074] Dampness-removing effect (traditional Chinese medicine diagnosis): For 50 subjects with heavy dampness: the thickness of the tongue coating decreased by 50% (in 14 days); the improvement rate of limb heaviness was 88%.

[0075] Component analysis: the content of polysaccharides in corn silk increased to 18.5 mg / g (12.3 mg / g in the non-fermented treatment group); the dissolution rate of potassium ions in Imperata cylindrica Beauv. increased by 30% (synergistic diuretic effect).

[0076] Safety: Acute toxicity test (LD50 > 15 g / kg, belonging to the actual non-toxic level); no liver and kidney damage was found in the long-term toxicity test (90 days).

[0077] The comprehensive data comparison table is as follows;

[0078] Through optimizing the formula and process, the present invention significantly improves the comprehensive performance of the product: Multi-effect synergy: Dampness-removing: Imperata cylindrica Beauv. and corn silk promote diuresis and discharge dampness, Poria cocos Schrad. invigorates the spleen and promotes diuresis, and the combination of the three enhances the water metabolism.

[0079] Sleep aid: Pine needles contain resin and β-carotene, which synergistically regulate the nerves with Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow and Arillus Longan, improving the sleep quality (clinical trials show that the sleep onset time is shortened by 38%).

[0080] Immunity enhancement: Astragalus polysaccharide and puerarin form a composite synergistic system, activating macrophages and enhancing the antiviral ability by 68%.

[0081] Cost optimization: Replacing Pseudostellaria heterophylla (Miq.) Pax with Poria cocos Schrad. and Bupleurum chinense DC. with corn silk, the auxiliary material cost is reduced by 30%.

[0082] Gradient temperature-controlled extraction (80°C → 95°C → 90°C) combined with enzymatic hydrolysis of cellulose increased the polysaccharide extraction rate to 12.8% (only 8.2% with the traditional process).

[0083] Process innovation: Nanocrystallization technology: Gypsum was ground to ≤100 nm and formed protective microcrystals with erythritol, and the retention rate of active ingredients was ≥90% (only 75% after traditional sterilization).

[0084] Ultra-high temperature instantaneous sterilization (135°C / 5 s): Microbiological indicators met the standards (total number of colonies ≤ 50 CFU / ml), and at the same time, long-term high-temperature damage to heat-sensitive components was avoided.

[0085] Universality and safety: The formula takes into account the damp-heat and cold-damp constitutions (such as Poria cocos strengthening the spleen and Tangerine peel regulating qi), and avoids the irritation of traditional lotus leaf tea to those with spleen and stomach deficiency and cold.

[0086] Acute toxicity test (LD50 > 15 g / kg) confirmed that it is actually non-toxic, and long-term drinking causes no liver and kidney damage.

[0087] Industrial adaptation: Standardized parameters (such as enzymatic hydrolysis pH 5.0, dynamic circulation flow rate 1.5 - 2.0 L / min) ensure mass production consistency, and the production cycle is shortened to 5 - 6 hours (traditionally 8 - 10 hours).

[0088] The present invention solves the problems of high cost, single efficacy, and easy loss of active ingredients in the prior art through material replacement, process innovation, and function integration, and has multiple effects such as removing dampness, promoting sleep, and immune regulation, and is suitable for the daily conditioning of sub-healthy people.

[0089] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device.

[0090] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made therein without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A health drink for improving sleep, expelling dampness and toxins, and enhancing immunity, characterized in that, By weight, it includes the following components: Main ingredients; Imperata cylindrica, Isatis indigotica, pine needles; Auxiliary materials; Poria cocos, Pueraria lobata, Citrus reticulata, Crataegus pinnatifida, corn silk, Glycyrrhiza glabra, Astragalus membranaceus, Mentha haplocalyx, Morus alba, Lonicera japonica, Chrysanthemum indicum; Functional additives; Nano-sized gypsum, erythritol.

2. The health care drink for improving sleep, expelling dampness and enhancing immunity according to claim 1, wherein The composition includes the following raw materials by weight: 60 - 200 parts of Imperata cylindrica, 50 - 100 parts of Isatis indigotica, 60 - 200 parts of pine needles, 14 - 40 parts of Poria cocos, 10 - 30 parts of Pueraria lobata, 10 - 25 parts of Citrus reticulata, 5 - 20 parts of Crataegus pinnatifida, 5 - 15 parts of corn silk, 15 - 30 parts of Glycyrrhiza glabra, 15 - 30 parts of Astragalus membranaceus, 15 - 25 parts of Mentha haplocalyx, 15 - 25 parts of Morus alba, 10 - 20 parts of Lonicera japonica, 10 - 20 parts of Chrysanthemum indicum, 5 - 15 parts of nano-sized gypsum, 5 - 15 parts of erythritol.

3. A health drink for improving sleep, expelling dampness and toxins, and enhancing immunity according to claim 1, wherein The nano-sized gypsum is calcium sulfate hydrate, and its particle size after ball milling is ≤100nm, which is used for nano-crystalline embedding of active ingredients.

4. A health drink for improving sleep, expelling dampness and toxins, and enhancing immunity according to claim 1, characterized in that, Among the auxiliary materials, Poria cocos, Pueraria lobata, and Citrus reticulata are all dried and crushed to 80 - 120 mesh, and Crataegus pinnatifida and corn silk are crushed to 60 - 100 mesh after low-temperature drying (50 - 60°C).

5. The preparation method of a health care drink for improving sleep, expelling toxins and dampness, and enhancing immunity according to any one of claims 1-4, characterized in that, Specifically, it includes the following steps: S1. Material pretreatment; Group A (fresh pine needles, fresh Imperata cylindrica) is broken after ultrasonic cleaning; Group B (Isatis indigotica, Poria cocos), Group C (Glycyrrhiza glabra, Astragalus membranaceus, Pueraria lobata) are respectively soaked for 45 minutes, and cellulase (50°C, pH5.0) is added for enzymatic hydrolysis for 1 hour; Group D (Lonicera japonica, Chrysanthemum indicum, corn silk), Group E (Mentha haplocalyx, Morus alba, Crataegus pinnatifida, Citrus reticulata) are respectively soaked for 30 minutes and broken; S2. Gradient temperature-controlled extraction; Group A is dynamically extracted at 80°C for 1 hour; Groups B and C are added, and the temperature is raised to 95°C for extraction for 30 minutes; Groups D and E are added, and extraction is carried out at 90°C for 40 minutes by circulation; S3. Negative pressure concentration and nano-crystallization; The extraction solution is vacuum concentrated (60°C, -0.08MPa) to 1 / 3 of the original volume; Nano-sized gypsum and erythritol are added, and stirred at 85°C for 45 minutes to form nano-crystals; S4. Sterilization and filling; Ultra-high temperature instantaneous sterilization (135°C, 5 seconds) is adopted, and it is cooled to 85 - 90°C for aseptic filling.

6. The preparation method of a health care drink for improving sleep, expelling dampness and toxins, and enhancing immunity according to claim 5, wherein: During the gradient temperature-controlled extraction process, a dynamic circulation system is adopted in each stage, and the flow rate is controlled at 1.5 - 2.0L / min.

7. The preparation method of a health care drink for improving sleep, expelling dampness and toxins, and enhancing immunity according to claim 5, characterized in that: In the nano-crystalline embedding process, the mass ratio of nano-sized gypsum to erythritol is 1:1 - 1:2.

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