Composition special for sensitive skin micro-ecological repair and preparation method thereof

Abstract

The invention discloses a special composition for micro-ecological repair of sensitive skin. The special composition comprises the following components in percentage by mass: 0.5-2.0% of a dendrobium officinale extract; 0.2%-1.0% of a purple coneflower extract; 0.3%-1.5% of a dogwood fruit extract; and the balance is a carrier. The invention aims to solve the problem of cooperative regulation of problems of micro-ecological imbalance, skin barrier fragility, chronic inflammation and the like in the sensitive skin care process. The synergistic effect of the three extracts is remarkable, the diversity of skin micro-ecology can be greatly improved, and the Shannon index reaches 3.5 or above; the release amount of an inflammatory factor IL-6 is effectively reduced and is controlled to be 15pg / mL or below; meanwhile, the skin barrier function is remarkably repaired, and the percutaneous water loss rate TEWL is reduced by 30% or above. Compared with a single component, the composition has the advantages that the repairing effect is improved by 40-60%, and the composition is non-irritant to skin. In addition, the invention also elaborates the preparation method of the composition and the specific application of the composition in the field of cosmetics in detail.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and specifically to a composition for microecological repair of sensitive skin and a preparation method thereof. Background Art

[0002] There are many deficiencies in the current sensitive skin repair products on the market:

[0003] 1. Poor microecological regulation ability: Most rely on a single prebiotic (such as α-glucan), and it is difficult to comprehensively and effectively regulate the microbial diversity (refer to CN113557891A);

[0004] 2. The barrier repair and anti-inflammatory functions are separated: Most products only focus on the repair of the physical barrier (such as using ceramide), but ignore the complex interaction between the microbiota-barrier-inflammation (refer to CN112402211A);

[0005] 3. The ingredients are irritating: Ingredients such as alcohol and fragrance will further aggravate the discomfort of sensitive skin (refer to CN112107466A). Summary of the Invention

[0006] The purpose of the present invention is to provide a composition for microecological repair of sensitive skin and a preparation method thereof to solve the problems raised in the above background art.

[0007] To achieve the above purpose, the present invention provides the following technical solutions:

[0008] A composition for microecological repair of sensitive skin contains the following components by mass percentage:

[0009] Dendrobium officinale extract 0.5 - 2.0%;

[0010] Echinacea purpurea extract 0.2 - 1.0%;

[0011] Cornus officinalis fruit extract 0.3 - 1.5%;

[0012] The balance is a carrier.

[0013] As a further solution of the present invention:

[0014] The Dendrobium officinale extract is the stem extract of Dendrobium officinale;

[0015] The Echinacea purpurea extract is the root extract of Echinacea purpurea.

[0016] As a further solution of the present invention: The carrier can be a substance recognized in the pharmaceutical or cosmetic field, such as at least one of glycerol, 1,2-pentanediol, and xanthan gum.

[0017] As a further solution of the present invention:

[0018] The polysaccharide content in the Dendrobium officinale extract is not less than 30%;

[0019] The chicoric acid content in the Echinacea purpurea extract is not less than 2%;

[0020] The loganin content in the Cornus officinalis fruit extract is not less than 5%.

[0021] As a further solution of the present invention: It also contains 0.5 - 3.0% of panthenol and 0.1 - 0.5% of ceramide NP.

[0022] A preparation method of a composition specifically for sensitive skin microecological repair, the specific steps are as follows:

[0023] a. Dissolve the Dendrobium officinale extract and the Cornus officinalis fruit extract in an aqueous phase at 60 - 65°C;

[0024] b. Pre - mix the Echinacea purpurea extract with 1,2 - pentanediol, and then add it to the aqueous phase;

[0025] c. Perform a homogenization and emulsification operation (rotation speed 2000 - 4000 rpm, time 5 - 10 minutes);

[0026] d. Cool down to below 40°C and add other active ingredients;

[0027] e. Adjust the pH value to 5.0 - 5.5, and then perform filtration and filling.

[0028] The composition specifically for sensitive skin microecological repair is applied to cosmetics with the functions of regulating skin microecology and repairing skin barrier function.

[0029] Compared with the prior art, the beneficial effects of the present invention are:

[0030] Aiming to solve the problem of the synergistic regulation of microecological imbalance, fragile skin barrier, and chronic inflammation during the care of sensitive skin

[0031] Verified by rigorous experiments, the three extracts have a significant synergistic effect, can greatly improve the diversity of skin microecology, making the Shannon index reach 3.5 or above; effectively reduce the release amount of inflammatory factor IL - 6, controlling it below 15 pg / mL; and at the same time significantly repair the skin barrier function, with the reduction amplitude of trans - epidermal water loss rate (TEWL) reaching 30% or above.

[0032] Compared with single components, the repair effect of the composition of the present invention is improved by 40-60%, and it is non-irritating to the skin. In addition, the present invention also elaborates in detail the preparation method of the composition and its specific applications in the field of cosmetics. Detailed implementation manners

[0033] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0034] Example 1

[0035] In the embodiment of the present invention, a composition specifically for sensitive skin microecology repair contains the following components by mass percentage:

[0036] Dendrobium officinale extract (polysaccharide content 35%) 0.5%; Echinacea purpurea extract (cichoric acid content 3%) 0.2%; Cornus officinalis fruit extract (loganin content 6%) 0.3%; 1,2-pentanediol 3.0%; glycerol 2.0%; panthenol 0.5%; ceramide NP 0.1%; the balance is deionized water.

[0037] A preparation method of a composition specifically for sensitive skin microecology repair, the specific steps are as follows:

[0038] a. Preparation of the aqueous phase: Add glycerol, Dendrobium officinale extract, and Cornus officinalis fruit extract to deionized water at 60°C, and stir at a speed of 300 rpm for 15 minutes until completely dissolved;

[0039] b. Premixing operation: Mix Echinacea purpurea extract with 1,2-pentanediol and disperse it under ultrasonic conditions of 40 kHz for 10 minutes;

[0040] c. Emulsification process: Slowly add the premixed solution to the aqueous phase, and use a T25 homogenizer to homogenize at a speed of 2000 rpm for 5 minutes;

[0041] d. Temperature adjustment: Cool to below 40°C and add other active ingredients;

[0042] e. Filtration and filling: Adjust the pH value to 5.0, filter through a 0.22 μm filter membrane, and then perform aseptic filling.

[0043] The composition specifically for sensitive skin microecology repair is applied to cosmetics with the functions of regulating skin microecology and repairing skin barrier.

[0044] Example 2

[0045] In an embodiment of the present invention, a composition specifically for sensitive skin microecosystem repair comprises the following components by mass percentage:

[0046] Dendrobium officinale extract (polysaccharide content 35%) 2.0%; Echinacea purpurea extract (cichoric acid content 3%) 1.0%; Cornus officinalis fruit extract (loganin content 6%) 1.5%; 1,2-pentanediol 8.0%; glycerol 5.0%; panthenol 3.0%; ceramide NP 0.5%; the balance is deionized water.

[0047] A preparation method of a composition specifically for sensitive skin microecosystem repair comprises the following specific steps:

[0048] a. Preparation of the aqueous phase: Add glycerol, Dendrobium officinale extract, and Cornus officinalis fruit extract to deionized water at 65 °C, and stir at a speed of 300 rpm for 15 minutes until completely dissolved;

[0049] b. Premixing operation: Mix the Echinacea purpurea extract with 1,2-pentanediol and disperse it under ultrasonic conditions of 40 kHz for 10 minutes;

[0050] c. Emulsification process: Slowly add the premixed solution to the aqueous phase, and use a T25 homogenizer to homogenize it at a speed of 4000 rpm for 10 minutes;

[0051] d. Temperature adjustment: Cool to below 40 °C and add other active ingredients;

[0052] e. Filtration and filling: Adjust the pH value to 5.5, filter through a 0.22 μm filter membrane, and then perform aseptic filling.

[0053] Example 3

[0054] In an embodiment of the present invention, a composition specifically for sensitive skin microecosystem repair comprises the following components by mass percentage:

[0055] Dendrobium officinale extract (polysaccharide content 35%) 1.2%; Echinacea purpurea extract (cichoric acid content 3%) 0.5%; Cornus officinalis fruit extract (loganin content 6%) 0.8%; 1,2-pentanediol 5.0%; glycerol 3.0%; panthenol 2%; ceramide NP 0.3%; the balance is deionized water.

[0056] A preparation method of a composition specifically for sensitive skin microecosystem repair comprises the following specific steps:

[0057] a. Preparation of the aqueous phase: Add glycerol, Dendrobium officinale extract, and Cornus officinalis fruit extract to deionized water at 62 °C, and stir at a speed of 300 rpm for 15 minutes until completely dissolved;

[0058] b. Premixing operation: Mix the Echinacea purpurea extract with 1,2-pentanediol and disperse it for 10 minutes under ultrasonic conditions of 40 kHz;

[0059] c. Emulsification process: Slowly add the premixed solution to the aqueous phase and homogenize it for 10 minutes at a speed of 3000 rpm using a T25 homogenizer;

[0060] d. Temperature adjustment: Cool to 35°C and add other active ingredients;

[0061] e. Filtration and filling: Adjust the pH value to 5.2, filter through a 0.22 μm filter membrane, and then perform aseptic filling. List of raw materials:

[0062]

[0063] The synergistic effect of the composition is as follows:

[0064]

[0065] Example 4

[0066] Skin microecological diversity test (using 16S rRNA sequencing technology)

[0067] Experimental design:

[0068] Divide the 3D human skin model (EpiDerm TM ) into 4 groups, with the number of samples in each group n = 6. Apply the essence prepared in Example 1 or the control product respectively and continuously apply for 7 days.

[0069] Collect skin surface flora samples and perform sequencing analysis using the Illumina MiSeq platform.

[0070] Experimental results:

[0071] Group Shannon index Proportion of beneficial bacteria (%) Blank control group 2.1±0.3 38±5 Three-component compound group 3.7±0.5 72±8

[0072] Example 5

[0073] Clinical efficacy verification (select 30 subjects with sensitive skin)

[0074] Test indicators:

[0075] Erythema index (measured using MX18)

[0076] Transepidermal water loss rate (measured by TM300)

[0077] Subjective stinging / burning sensation score (score range 0 - 4 points).

[0078] Experimental results (experimental period: 28 days):

[0079] Index Blank control group Three-component compound group Redness index reduction rate (%) 12±5 46±9 TEWL reduction rate (%) 8±3 35±7 Stinging sensation score (points) 2.1±0.6 0.4±0.2

[0080] In addition, it should be understood that although this specification is described according to the embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A composition specifically for sensitive skin microecosystem repair, characterized in that, It contains the following components by mass percentage: Dendrobium officinale extract 0.5 - 2.0%; Echinacea purpurea extract 0.2 - 1.0%; Cornus officinalis fruit extract 0.3 - 1.5%; The balance is carrier.

2. The composition specifically for sensitive skin microecosystem repair according to claim 1, wherein, The Dendrobium officinale extract is the stem extract of Dendrobium officinale; the Echinacea purpurea extract is the root extract of Echinacea purpurea.

3. The composition specifically for sensitive skin microecosystem repair according to claim 1 or 2, characterized in that The carrier is at least one of glycerol, 1,2 - pentanediol, and xanthan gum.

4. The composition specifically for sensitive skin microecosystem repair according to claim 3, characterized in that the polysaccharide content in the Dendrobium officinale extract is not less than 30%; the chicoric acid content in the Echinacea purpurea extract is not less than 2%; the loganin content in the Cornus officinalis fruit extract is not less than 5%.

5. The composition specifically for sensitive skin microecosystem repair according to claim 4, characterized in that, It also contains 0.5 - 3.0% of panthenol and 0.1 - 0.5% of ceramide NP.

6. A method for preparing a composition specifically for sensitive skin microecology repair as described in claim 5, characterized in that, The specific steps are as follows: a. Dissolve the Dendrobium officinale extract and the Cornus officinalis fruit extract in the water phase at 60 - 65 °C; b. Pre - mix the Echinacea purpurea extract with 1,2 - pentanediol and then add it to the water phase; c. Perform a homogenization and emulsification operation; d. Cool down to below 40 °C and add other active ingredients; e. Adjust the pH value to 5.0 - 5.5, and then perform filtration and filling.

7. The composition specifically for sensitive skin microecosystem repair according to claim 6, characterized in that, In step C, a homogenizer is used to homogenize for 5 - 10 minutes at a rotation speed of 2000 - 4000 rpm. The composition specifically for sensitive skin microecosystem repair is applied to cosmetics with the functions of regulating skin microecosystem and repairing skin barrier function.

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