Traditional Chinese medicine compound acupoint patch for treating cold-dampness gastrointestinal diseases as well as preparation method and application of traditional Chinese medicine compound acupoint patch

Abstract

The invention discloses a traditional Chinese medicine compound acupoint patch for treating cold-dampness gastrointestinal diseases as well as a preparation method and application of the traditional Chinese medicine compound acupoint patch. The traditional Chinese medicine compound acupoint patch is prepared from coptis chinensis, myristica fragrans, cassia twig, fructus evodiae, rhizoma zingiberis and borneol. The invention further discloses a preparation method of the traditional Chinese medicine compound acupoint patch and application of the traditional Chinese medicine compound acupoint patch in preparation of medicines for treating cold-dampness gastrointestinal diseases. The traditional Chinese medicine compound acupoint patch is simple in prescription, high in safety, remarkable in curative effect on cold-dampness gastrointestinal diseases and suitable for popularization and utilization.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine. More specifically, it relates to a traditional Chinese medicine compound acupoint patch for treating cold-damp gastroenteric diseases, its preparation method and application. Background Art

[0002] Cold-damp intestinal diseases are mainly manifested as abdominal pain, abdominal distension and diarrhea. Diarrhea refers to a disease syndrome mainly manifested by increased frequency of defecation, thin or undigested food mixed in feces, and even diarrhea like water. Among them, the slow and thin stool is called "diarrhea", and the clear and watery stool like water and with a rapid onset is called "diarrhea". The two are collectively called diarrhea. This disease syndrome was described in detail in "Huangdi Neijing" as early as in ancient times, such as the classic statements "excessive dampness causes loose stools" and "when the clear qi is in the lower part, diarrhea with undigested food occurs", which revealed its etiology and pathogenesis. From the perspective of modern medicine, diarrhea caused by various diseases such as chronic gastritis, chronic colitis, irritable bowel syndrome, gastrointestinal dysfunction, and intestinal flora imbalance can be included in the category of "diarrhea" in traditional Chinese medicine. In recent years, with the rapid development of social economy and the transformation of lifestyle, the incidence of chronic gastrointestinal inflammation and related diseases has shown an upward trend globally. The symptoms are prolonged and repeated, which not only causes a huge burden on medical expenses, but also seriously affects the quality of life and work efficiency of patients. Some chronic changes tend to turn malignant. At present, the western medicine treatment is mainly symptomatic support, including measures such as regulating intestinal flora and antidiarrheal, but it is mostly limited to symptom relief, with poor long-term efficacy and high recurrence rate. In contrast, traditional Chinese medicine pays attention to syndrome differentiation and treatment, emphasizes treating both the symptoms and the root cause, and has achieved remarkable curative effects in clinical practice. Guo Ziguang, a master of traditional Chinese medicine, emphasized the important role of spleen-yang deficiency in the pathogenesis of diarrhea, pointing out that "when spleen-yang is deficient, internal cold is generated, and when transportation and transformation are disordered, water and grains stagnate", emphasizing the pathological process that spleen-yang failure leads to internal generation of cold-dampness and confusion between the clear and the turbid, and finally resulting in the protracted diarrhea. Master Fang Heqian believes that the key to the pathogenesis of diarrhea lies in spleen qi deficiency and cold and failure of transportation and transformation. The clinical manifestations of patients with diarrhea of spleen deficiency and cold-dampness syndrome have the following characteristics: the main symptoms are intestinal symptoms such as increased frequency of defecation, thin and loose stools, and even undigested grains, which may be accompanied by abdominal cold pain, abdominal distension, and often accompanied by symptoms such as urgent defecation intention and incomplete defecation. This syndrome has obvious characteristics of cold-dampness causing diseases, and its symptoms tend to be aggravated in winter or after being affected by exogenous cold pathogens, which is in line with the pathogenesis characteristics of "cold causing contraction" and "dampness being turbid and heavy".

[0003] Currently, traditional Chinese medicine preparations for treating cold-dampness gastroenteropathy mostly adopt the oral administration route. Although the treatment effect is good, chronic patients need to take medicine for a long time, which is likely to cause gastrointestinal irritation reactions and liver and kidney burdens, resulting in reduced treatment compliance; oral preparations undergo the first-pass effect through gastrointestinal metabolism, leading to a loss of bioavailability; the traditional oral medication method is difficult to combine with the theory of traditional Chinese medicine time medicine, and it is difficult to achieve the synergistic effect of chronopharmacodynamics. However, acupoint application can enhance acupoint sensitivity and drug targeting: according to the law of the flow of meridian qi and blood, the excitability of acupoints increases at specific times, and the applied drugs can be more efficiently conducted to the diseased area through the acupoint-meridian system, reducing peripheral metabolic loss, enhancing the drug targeting aggregation degree, and achieving the synergistic effect of pharmacodynamics.

[0004] Therefore, there is an urgent need to provide an external transdermal preparation for treating cold-dampness gastroenteropathy, which can be applied through acupoint application with specific effects, and can also be used according to the method of traditional Chinese medicine time medicine to enhance the curative effect and facilitate patients to adhere to the use in daily life. Summary of the Invention

[0005] In view of the above technical problems, one object of the present invention is to provide a new traditional Chinese medicine compound acupoint patch, which can effectively treat cold-dampness gastroenteropathy, has a delicate prescription and is convenient for long-term use.

[0006] Another object of the present invention is to provide a preparation method of the above traditional Chinese medicine compound acupoint patch.

[0007] Still another object of the present invention is to provide the application of the above traditional Chinese medicine compound acupoint patch in the preparation of drugs for treating cold-dampness gastroenteropathy.

[0008] To achieve the above objects, the present invention adopts the following technical solutions:

[0009] In the first aspect, the present invention provides a traditional Chinese medicine compound acupoint patch for treating cold-dampness gastroenteropathy, which is prepared from the following raw materials: Coptis chinensis, Nutmeg, Cinnamon Twig, Evodia rutaecarpa, Dried Ginger and Borneol.

[0010] The prescription of the present invention consists of two pungent-warm herbs, Nutmeg and Cinnamon Twig, two pungent-hot herbs, Evodia rutaecarpa and Dried Ginger, the bitter-cold counteracting drug Coptis chinensis and the transdermal agent Borneol. The effects of each raw material are as follows:

[0011] Nutmeg, "Compendium of Materia Medica": "Warm the spleen and stomach, and strengthen the large intestine." Nutmeg is pungent in taste and warm in nature, and has the effects of astringing the intestine to stop diarrhea and warming the middle energizer to promote qi movement, and is mainly used to treat symptoms such as chronic diarrhea and cold pain in the epigastric and abdominal regions. Cinnamon Twig, "Shennong's Classic of Materia Medica": "Pungent in taste, warm. It is mainly used for cough and dyspnea due to upward adverse qi, stagnant qi in the throat, shortness of breath, promoting joint movement, and tonifying the middle qi." Nutmeg is warm and astringent, entering the spleen, stomach and large intestine meridians, warming the middle energizer to dispel cold, and Cinnamon Twig is pungent, sweet and warm, belonging to the heart, lung and bladder meridians, promoting qi movement and activating yang. The combination of the two drugs, one stops and one moves, one is static and the other is dynamic, assisting yang to dispel cold, warming the zang-fu organs and dredging the meridians.

[0012] Evodia rutaecarpa, Compendium of Materia Medica: "Evodia rutaecarpa, pungent and hot, can dissipate and warm, bitter and hot, can dry and firm, so the symptoms it treats are all based on its ability to dissipate cold, warm the middle, and relieve depression." Evodia rutaecarpa has the characteristics of strong smell and dryness. The irritation of the drug is also suitable for external treatment, and it is good at treating pain caused by cold stagnation. Dried ginger, Shennong's Herbal Classic: "It is used to treat chest fullness, cough, reverse breathing, warm the middle, stop bleeding, sweat, expel rheumatism, and diarrhea." Dried ginger is pungent and hot in nature, and is an important medicine for warming the middle and dispersing cold. The combination of warm and hot medicines can warm the middle and stop diarrhea, dissipate cold and relieve pain, warm the yang, promote water and remove dampness.

[0013] Huanglian, "Shennong's Herbal Classic": "It is used to treat heat, eye pain, canthus injury, tearing, clearing the eyes, intestinal diarrhea, abdominal pain, diarrhea, and swelling and pain in the genitals of women."

[0014] Borneol tastes pungent, bitter and slightly cold; it has a refreshing and dispersing fragrance and is mobile in nature, which can promote transdermal absorption.

[0015] This prescription is suitable for patients suffering from chronic gastritis, chronic enteritis, irritable bowel syndrome, gastrointestinal dysfunction, intestinal flora imbalance, etc., and patients diagnosed with spleen yang deficiency and cold and dampness in traditional Chinese medicine.

[0016] Furthermore, the Chinese medicine compound acupuncture patch is made of the following raw materials in parts by weight: 1-10 parts of coptis root, 1-10 parts of nutmeg, 2-20 parts of cassia twig, 1-10 parts of evodia rutaecarpa, 1-10 parts of dried ginger and 0.01-0.05 parts of borneol.

[0017] Exemplarily, the Chinese herbal compound acupuncture patch is made of the following raw materials in parts by weight: 1 part of coptis root, 1 part of nutmeg, 2 parts of cassia twig, 1 part of evodia rutaecarpa, 1 part of dried ginger and 0.05 parts of borneol.

[0018] Exemplarily, the Chinese herbal compound acupuncture patch is made of the following raw materials in parts by weight: 1 part of coptis root, 2 parts of nutmeg, 4 parts of cassia twig, 2 parts of evodia rutaecarpa, 2 parts of dried ginger and 0.05 parts of borneol.

[0019] In a second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine compound acupuncture patch, the preparation method comprising the following steps:

[0020] (1) Mix coptis root, nutmeg, cassia twig, evodia rutaecarpa, dried ginger and borneol according to the prescribed amount and grind into powder;

[0021] (2) The ointment is prepared with yellow wine, wherein the mass ratio of the medicinal powder to the yellow wine is (0.5-1):1.

[0022] Furthermore, the preparation method also includes placing the ointment on a blank breathable adhesive patch, and the blank breathable adhesive patch can be purchased through commercial channels, for example, a blank breathable adhesive patch made of medical-grade non-woven fabric material.

[0023] Thirdly, the present invention also provides the use of the above-mentioned traditional Chinese medicine compound acupoint patch in the preparation of a medicament for treating cold-dampness gastrointestinal diseases.

[0024] Furthermore, the cold-dampness gastrointestinal diseases include chronic gastritis, chronic enteritis, irritable bowel syndrome, gastrointestinal dysfunction, intestinal flora imbalance, etc.

[0025] Furthermore, the acupoints to which the traditional Chinese medicine compound acupoint patch is applied include Zhongwan, Shenque, Guanyuan and Tianshu.

[0026] In addition, unless otherwise specified, each raw material drug of the external traditional Chinese medicine composition of the present invention can be obtained through commercial purchase. Any range described in the present invention includes the end values and any numerical value between the end values, and the traditional Chinese medicine composition of any sub-range constituted by any numerical value between the end values or the end values can achieve the therapeutic purpose.

[0027] The beneficial effects of the present invention are as follows:

[0028] The acupoint patch prescription of the present invention is ingenious, breaking through the traditional single-formulation idea of "warming yang and dispelling cold". It uses warm drugs (such as nutmeg and cinnamon twig) and hot drugs (such as evodia rutaecarpa and dried ginger) in combination to form a "warm → hot" gradient effect, reflecting a unique compatibility mode of the gradient warming mechanism. Moreover, by using the gradient change of warm and hot drugs, it can synergistically enhance the Na + / K + -ATPase activity and promote heat production. The compatibility of 2 warm and 2 hot drugs in the prescription 2 of the present invention further verifies its unique synergistic significance from the clinical effect. In addition, the counteracting compatibility of the bitter and cold drug coptis chinensis reflects the wisdom of "using cold and heat together and regulating yin and yang". The addition of a cold drug to a piece of hot drugs can reconcile cold and heat, prevent drug rejection, restrict the drug properties, and protect the spleen and stomach. This kind of compatibility reflects the treatment concept of "making the best use of the situation". By adjusting the bias of the drugs, it makes them more suitable for the pathological state of the patients, achieving the purpose of yin-yang balance, and thus effectively treating cold-dampness gastrointestinal diseases.

[0029] The acupoint patch of the present invention has obvious advantages compared with oral traditional Chinese medicine. Firstly, it reduces gastrointestinal irritation. The drug is absorbed through the skin, avoiding direct irritation to the gastrointestinal tract, and is suitable for patients with weak gastrointestinal function or sensitive to oral drugs; dual local and systemic effects: the drug acts directly on the local through acupoints, and at the same time regulates the whole body through meridians, and the curative effect is more accurate; it is convenient to use, without the need for decocting or swallowing, and is simple to use, especially suitable for children, the elderly and those with difficulty in swallowing; it has few side effects. The drug does not undergo the first-pass effect of the liver, reducing systemic side effects and having high safety. It has a continuous effect, the drug is slowly released, and the action time is longer, reducing the need for frequent medication; it has high compliance, is convenient to use, and patients are more likely to adhere to the treatment, especially suitable for patients with long-term chronic gastrointestinal diseases; it avoids the first-pass effect, the drug does not undergo liver metabolism, improving the bioavailability; it reduces drug interactions, has fewer interactions with other drugs, and is suitable for patients using multiple drugs simultaneously. DETAILED DESCRIPTION

[0030] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0031] Example 1

[0032] A Chinese medicine compound acupuncture point patch for treating cold-damp gastrointestinal diseases

[0033] Raw material medicine formula: 10g of Coptis chinensis, 10g of nutmeg, 20g of cinnamon twig, 10g of Evodia rutaecarpa, 10g of dried ginger, and 0.5g of borneol.

[0034] The preparation method is as follows:

[0035] (1) Mix coptis root, nutmeg, cassia twig, evodia rutaecarpa, dried ginger and borneol according to the prescribed amount and grind into powder;

[0036] (2) The ointment is prepared with yellow wine, wherein the mass ratio of the medicinal powder to the yellow wine is 1:1.

[0037] (3) Place the ointment on a blank breathable adhesive patch.

[0038] Example 2

[0039] A Chinese medicine compound acupuncture point patch for treating cold-damp gastrointestinal diseases

[0040] Raw material medicine formula: 10g of Coptis chinensis, 20g of nutmeg, 40g of cinnamon twig, 20g of Evodia rutaecarpa, 20g of dried ginger, and 0.5g of borneol.

[0041] The preparation method is as follows:

[0042] (1) Mix coptis root, nutmeg, cassia twig, evodia rutaecarpa, dried ginger and borneol according to the prescribed amount and grind into powder;

[0043] (2) The ointment is prepared with yellow wine, wherein the mass ratio of the medicinal powder to the yellow wine is 1:1.

[0044] (3) Place the ointment on a blank breathable adhesive patch.

[0045] The method of using the acupoint patch prepared according to the present invention is simple, and the acceptance rate of patients is high. Before use, it is necessary to clean the skin of the patient's acupoint area to ensure that there is no oil stain, sweat, etc., so as to ensure that the acupoint patch can fit closely. Apply the prepared acupoint patch on the designated acupoints (see the following acupoint combinations for details), and gently press to fix it. According to the severity of the condition and individual differences, the application time can be adjusted appropriately. Generally, it is recommended that adults apply it for 4 to 6 hours each time, and the application time for children should be shortened appropriately. During the use process, the patient may feel slight fever, tingling or itching at the acupoint area, which is a normal reaction of the drug stimulating the acupoints and activating the meridian function.

[0046] Acupoint combination:

[0047] Longitudinal axis of triple energizer connection

[0048] - Upper energizer: Zhongwan (4 inches above the umbilicus), belonging to the front mu point of the stomach, regulates the ascending and descending of the spleen and stomach;

[0049] - Middle energizer: Shenque (in the middle of the umbilicus), the pivot of the Conception Vessel, warms and dredges the original yang;

[0050] - Lower energizer: Guanyuan (3 inches below the umbilicus), the front mu point of the small intestine, nourishes the original qi;

[0051] - Cooperate with Tianshu (2 inches beside the umbilicus), the front mu point of the large intestine, to horizontally regulate the large intestine, forming a "upper-middle-lower-horizontal" four-dimensional space structure;

[0052] The nerve regulation network of the four acupoints covers the spinal ganglion segments of T6-L1: Zhongwan corresponds to T9-T10 (innervating the stomach), Shenque corresponds to T10 (innervating the transverse colon), Guanyuan corresponds to L1 (innervating the small intestine), and Tianshu corresponds to T12-L1 (innervating the descending colon), forming a complete autonomic nerve regulation loop.

[0053] Zhongwan: Strengthens the spleen and harmonizes the stomach, regulates the secretion of Ghrelin, promotes appetite, and enhances the vagus nerve activity when combined with Shenque;

[0054] Shenque: Warms yang and dispels cold, activates the thermogenesis of brown adipose tissue, and increases the basal metabolic rate by 15% when combined with Guanyuan;

[0055] Guanyuan: Tonifies the kidney and cultivates the original qi, regulates the AMPK / mTOR pathway, delays aging, and promotes the proliferation of intestinal stem cells when combined with Tianshu;

[0056] Tianshu: Regulates the large intestine, regulates the pacing activity of interstitial cells of Cajal, and optimizes the gastro-colonic reflex when combined with Zhongwan;

[0057] This acupoint combination breaks through the limitations of traditional local acupoint selection, and through the synergistic effects of multiple targets and multiple dimensions, forms a complete treatment system of "strengthening the spleen - warming yang - tonifying the kidney - regulating the intestine".

[0058] Experimental example 1

[0059] 1 Data and Methods

[0060] 1.1 General Data

[0061] Patients diagnosed with diarrhea due to spleen deficiency and cold-dampness syndrome in traditional Chinese medicine and chronic colitis, ulcerative colitis, irritable bowel syndrome, and gastrointestinal dysfunction in Western medicine who were treated in our outpatient department from June 2023 to December 2024 were selected, with a total of 550 cases (among them, 448 cases were concentrated for application during the three fu periods in two years as the sanfu application in our department). The male-female ratio was approximately 1:1.72. There were 90 cases aged 19 - 30 years, 193 cases aged 31 - 45 years, 150 cases aged 46 - 60 years, and 117 cases aged over 60 years. 181 cases had chronic gastritis, accounting for 32.91%, 59 cases had irritable bowel syndrome, accounting for 10.76%, and the proportion of patients with diseases such as chronic colitis, intestinal flora dysregulation, chronic proctitis, and gastrointestinal dysfunction was between 5% and 10%. The largest number of patients had a disease course of more than 12 months, with a total of 296 cases, accounting for 53.80%, followed by 3 - 6 months, with a total of 174 cases, accounting for 31.65%.

[0062] 1.2 Diagnostic Criteria

[0063] 1.2.1 Western Medicine Diagnostic Criteria

[0064] Refer to the diagnostic criteria for chronic gastritis, chronic enteritis, diarrhea-predominant irritable bowel syndrome, intestinal flora dysregulation, and gastrointestinal dysfunction in "Gastroenterology".

[0065] 1.2.2 Traditional Chinese Medicine Diagnostic Criteria

[0066] Refer to "Expert Consensus on the Diagnosis and Treatment of Diarrhea in Traditional Chinese Medicine (2023)" and "Diagnostic and Therapeutic Criteria for Traditional Chinese Medicine Syndromes" for syndrome differentiation and typing.

[0067] Syndrome of cold-dampness stagnating the spleen: Main symptoms: Loose stools or like water; abdominal pain with borborygmus. Secondary symptoms: Loss of appetite; fullness and distension in the epigastric and abdominal regions; heaviness and discomfort in the head and body; nausea and desire to vomit; sticky or tasteless mouth; aversion to cold and fever. Tongue and pulse: Thin white or white greasy tongue coating; soft and slow or deep and thready pulse.

[0068] 1.3 Inclusion and Exclusion Criteria

[0069] 1.3.1 Inclusion Criteria

[0070] ①Diagnosed as chronic gastritis, chronic enteritis, diarrhea-predominant irritable bowel syndrome, intestinal flora dysregulation, gastrointestinal dysfunction, etc. in Western medicine, and diagnosed as diarrhea disease, syndrome of cold-dampness stagnating the spleen in traditional Chinese medicine; ②Disease course ≥ 3 months; ③Age ≥ 18 years. ④Not taking drugs for treating gastrointestinal diseases simultaneously.

[0071] 1.3.2 Exclusion Criteria

[0072] ① Severe diabetes, blood diseases, malignant hypertension, severe cardiovascular and cerebrovascular diseases, severe liver and kidney dysfunction; ② Patients with yin deficiency constitution or fever; ③ Patients with scar constitution, redness or ulcer on the skin surface of acupoints; ④ Patients with allergic constitution or allergic to the application drugs; ⑤ Chickenpox, eczema, contact dermatitis; ⑥ Patients who cannot complete the full course of treatment; ⑦ Pregnant women, during menstruation, infants and young children.

[0073] 1.4 Treatment method

[0074] The nursing staff explains the application indications to the patients, and explains the acupoint selection method and application method: Select Zhongwan, Guanyuan, Shenque, Tianshu (bilateral). Each application lasts for 3 consecutive days, with a 1-week rest, then another 3-day application, followed by another 1-week rest, and finally another 3-day application. A total of 9 days of application are carried out within 23 days for one course of treatment. Each application lasts for 2 - 4 hours. After the application is completed, remove the application patch and clean the skin. If adverse reactions such as itching, redness, blisters occur, do not scratch. Guide the patients to have a healthy and light diet, avoid spicy, stimulating, raw and cold foods, and avoid alcohol. Symptom assessment is performed before treatment and 1 month after the course of treatment.

[0075] 1.5 Efficacy evaluation criteria

[0076] Referring to the "Guiding Principles for Clinical Research of New Chinese Medicines (Trial)", based on the total symptom scores before and after treatment and the improvement percentage, the efficacy of chronic gastrointestinal diseases is evaluated according to the efficacy formula. The formula of Nimodipine method is: Efficacy index = (Score before treatment - Score after treatment) / Score before treatment × 100%; Generally speaking, an efficacy index ≥ 95% is defined as clinical cure, 70% ≤ efficacy index < 95% is defined as marked effect, 30% ≤ efficacy index < 70% is defined as effective, and efficacy index < 30% is defined as ineffective.

[0077] Specifically as follows:

[0078] Table 1 Clinical efficacy evaluation

[0079]

[0080] Table 2 Single symptom score table

[0081]

[0082]

[0083] Table 3 Comparison of scores of spleen-stomach system PRO scale

[0084]

[0085] 2. Results

[0086] It can be seen from Table 1-3 that among 550 patients, 332 cases showed marked improvement, 121 cases had effective results, 93 cases were ineffective, and the total effective rate was 82.36%. Among them, 448 people were treated during the dog days, and the total effective rate was 89.06%, which was more effective than that during non-dog days, and the difference was statistically significant (P<0.05). Comparison of single symptom scores before and after treatment: The symptom scores of diarrhea, abdominal pain, abdominal distension, gastric distension, sticky stools, acid reflux / heartburn / nausea, and alternating diarrhea and constipation all decreased, p<0.05, and the difference was statistically significant. Comparison of the scores of the spleen and stomach system PRO scale showed that there were statistically significant differences in the scores of defecation, reflux, dyspepsia, mental state, and overall state before and after treatment in patients (p<0.05), and there was no statistical difference in the symptom scores of health satisfaction and social function before and after treatment (p>0.05). Only a small number of patients (4.90%) had skin allergies after application, and the rest of the patients had no discomfort symptoms.

[0087] 3. Discussion

[0088] Through long-term clinical observation of a large sample, the traditional Chinese medicine compound acupoint application of the present invention has obvious curative effects on cold-dampness gastrointestinal diseases. The total effective rate reaches 82.36%. Combined with the characteristics of traditional Chinese medicine time medicine and used during the dog days, the total effective rate even reaches 89.06%. The traditional Chinese medicine compound acupoint application of the present invention has few medicinal flavors, is concentrated and precise in action, and is convenient for external use. It can dispel cold and dampness and warm the middle-jiao and strengthen the spleen for cold-dampness gastrointestinal diseases.

[0089] Obviously, the above-mentioned embodiments of the present invention are merely examples for clearly illustrating the present invention, rather than limiting the implementation manners of the present invention. For those of ordinary skill in the art, other different forms of changes or variations can be made on the basis of the above description. It is impossible to list all the implementation manners here. Any obvious changes or variations derived from the technical solutions of the present invention are still within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine compound acupoint patch for treating cold-dampness gastroenteric diseases, characterized in that, The traditional Chinese medicine compound acupuncture patch is prepared from the following raw materials: coptis root, nutmeg, cassia twig, evodia rutaecarpa, dried ginger and borneol.

2. The traditional Chinese medicine compound acupoint patch according to claim 1, wherein, The traditional Chinese medicine compound acupuncture patch is prepared from the following raw materials in parts by weight: 1-10 parts of coptis root, 1-10 parts of nutmeg, 2-20 parts of cassia twig, 1-10 parts of evodia rutaecarpa, 1-10 parts of dried ginger and 0.01-0.05 parts of borneol.

3. The traditional Chinese medicine compound acupoint patch according to claim 2, wherein, The Chinese medicine compound acupuncture patch is prepared from the following raw materials in parts by weight: 1 part of coptis root, 1 part of nutmeg, 2 parts of cassia twig, 1 part of evodia rutaecarpa, 1 part of dried ginger and 0.05 part of borneol.

4. The traditional Chinese medicine compound acupoint patch according to claim 2, wherein The Chinese medicine compound acupuncture patch is prepared from the following raw materials in parts by weight: 1 part of coptis root, 2 parts of nutmeg, 4 parts of cassia twig, 2 parts of evodia rutaecarpa, 2 parts of dried ginger and 0.05 parts of borneol.

5. The preparation method of the traditional Chinese medicine compound acupoint patch for treating cold-dampness gastroenteric diseases according to any one of claims 1-4, characterized in that, The preparation method comprises the following steps: (1) Mix coptis root, nutmeg, cassia twig, evodia rutaecarpa, dried ginger and borneol according to the prescribed amount and grind into powder; (2) The ointment is prepared with yellow wine, wherein the mass ratio of the medicinal powder to the yellow wine is (0.5-1):

1.

6. The preparation method according to claim 5, characterized in that The preparation method also includes placing the ointment on the blank breathable adhesive patch.

7. The preparation method according to claim 5, characterized in that, The drug powder is sieved through a 300-400 mesh sieve.

8. Use of the Chinese herbal compound acupuncture patch for treating cold-damp gastrointestinal diseases as described in any one of claims 1 to 4 or the Chinese herbal compound acupuncture patch prepared by the preparation method as described in any one of claims 5 to 7 in preparing a medicament for treating cold-damp gastrointestinal diseases.

9. The application according to claim 8, wherein The cold-damp gastrointestinal diseases include chronic gastritis, chronic enteritis, irritable bowel syndrome, gastrointestinal dysfunction, and intestinal flora imbalance.

10. The application according to claim 8, characterized in that, The acupoints applied by the Chinese medicine compound acupoint patch include Zhongwan, Shenque, Guanyuan and Tianshu.

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