Traditional Chinese medicine beverage composition for improving sub-health and preparation method thereof

Abstract

The traditional Chinese medicine beverage composition is prepared from the following raw materials in parts by weight: 10 to 30g of albumin peptide, 5 to 20g of raw Chinese yam, 3 to 15g of semen euryales, 2 to 10g of pericarpium citri reticulatae, 1 to 8g of endothelium corneum gigeriae galli, 3 to 12g of roasted malt, 2 to 10g of scorched hawthorn fruit, 5 to 15g of rhizoma polygonati, 10 to 15g of radix astragali seu hedysari, 3 to 10g of semen ziziphi spinosae, 2 to 8g of lotus leaf, 3 to 12g of honeysuckle flower, 1 to 5g of herba menthae, 2 to 10g of flos chrysanthemi, 0.5 to 5g of earthworm peptide, 3 to 10g of radix angelicae sinensis and 2 to 8g of radix platycodonis. , 3-10 g of fructus alpiniae oxyphyllae, 8-12 g of codonopsis pilosula and 3-12 Through the synergistic effect of multiple components, the immunity is enhanced, multiple effects of invigorating stomach and spleen, replenishing qi and enriching blood, regulating viscera and the like are also achieved, and the concept of overall conditioning of traditional Chinese medicine is met. And aiming at sub-health states such as low immunity and weakness of the spleen and the stomach, various physiological imbalance problems are covered, and the application scene is wider. The active ingredients such as polysaccharide and saponin in the medicinal materials, such as astragalus polysaccharide and polygonatum sibiricum saponin, are high in retention rate due to the freeze-drying process.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine beverage composition for improving sub-healthy state by compounding natural medicinal materials and its freeze-drying preparation process. Background Art

[0002] Currently, the sub-healthy population generally has problems such as low immunity and weak spleen and stomach. Most of the commercially available health products have problems such as single composition, low absorption rate or containing chemical additives.

[0003] For example, a traditional Chinese medicine composition for antioxidant and / or immune enhancement, its preparation method and application disclosed in patent publication number CN117919321A contains three components: freeze-dried royal jelly, grape seed extract, and broken-wall pine pollen. The formula is simple. Although it has the effects of antioxidant and immune enhancement, its functions are relatively single and do not reflect the multi-target synergistic effect. Focusing on antioxidant and immunity improvement, it does not mention the comprehensive improvement of sub-healthy states such as fatigue and qi and blood deficiency, and the indication range is relatively narrow. It is only a physical mixing process, directly mixing freeze-dried royal jelly, grape seed extract, etc., without involving extraction or concentration steps, which may lead to loss of active ingredients or low absorption rate. Containing freeze-dried royal jelly may cause allergic reactions, and no microbial control measures are mentioned, so the applicable population is limited. For example, people with allergic constitution need to be cautious. Only traditional dosage forms such as capsules and tablets are provided, without optimizing the taste or usability, which may reduce user compliance.

[0004] Traditional traditional Chinese medicine compound preparations have defects such as rough process, large loss of active ingredients, and inconvenient administration. Summary of the Invention

[0005] Provide a portable traditional Chinese medicine beverage with functions of strengthening the stomach and spleen, supplementing qi and blood, and regulating immune function, and improve the retention rate of active ingredients by optimizing the extraction process.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] (1) Composition:

[0008] It is composed of the following raw materials in parts by weight: 10 - 30 g of albumin peptide, 5 - 20 g of fresh Chinese yam, 3 - 15 g of gorgon fruit, 2 - 10 g of dried tangerine peel, 1 - 8 g of chicken gizzard-membrane, 3 - 12 g of stir-fried malt, 2 - 10 g of stir-fried hawthorn, 5 - 15 g of polygonatum sibiricum, 10 - 15 g of astragalus membranaceus, 3 - 10 g of wild jujube seed, 2 - 8 g of lotus leaf, 3 - 12 g of honeysuckle, 1 - 5 g of mint, 2 - 10 g of chrysanthemum, 0.5 - 5 g of earthworm peptide, 3 - 10 g of angelica sinensis, 2 - 8 g of platycodon grandiflorum, 3 - 10 g of semen myristicae, 8 - 12 g of codonopsis pilosula, 3 - 12 g of cistanche deserticola.

[0009] (2) Preparation method:

[0010] a. Mix the medicinal materials except albumin peptides in proportion, add 8 - 12 times the amount of water and decoct for 2 - 3 times, each time for 1 - 2 hours;

[0011] b. Combine the decoctions and concentrate to a relative density of 1.10 - 1.25 (60 °C);

[0012] c. Add albumin peptides and mix well, then make into a powder of 100 - 200 mesh through freeze - drying or spray - drying;

[0013] d. Package in bags of 50 g each and irradiate for sterilization.

[0014] In summary, the present invention includes at least one of the following beneficial technical effects:

[0015] Through the synergistic effect of multiple components, it not only enhances immunity, but also takes into account multiple effects such as strengthening the stomach and spleen, replenishing qi and blood, and regulating the zang - fu organs, which conforms to the concept of overall conditioning in traditional Chinese medicine.

[0016] Specifically targeting sub - healthy states, such as low immunity and weak spleen and stomach, covering a variety of physiological imbalance problems, with a wider application scenario.

[0017] Active ingredients such as polysaccharides and saponins in the medicinal materials, such as astragalus polysaccharide and polygonatum saponin, and the freeze - drying process enables a high retention rate of active ingredients.

[0018] The powder form is convenient to carry and has a high bioavailability.

[0019] All the ingredients in the formula are both edible and medicinal ingredients, such as Chinese yam, hawthorn, and dried tangerine peel, with high safety, suitable for long - term use, and the irradiation sterilization ensures that the microbial indicators are qualified.

[0020] The final product is a powder of 100 - 200 mesh, which can be directly brewed and taken orally, taking into account both portability and quick solubility, meeting the needs of modern fast - paced life. Detailed implementation method

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0022] Example 1:

[0023] A composition, for preparing 1000 g, consists of the following raw materials in parts by weight:

[0024] 30 g of albumin peptide, purity ≥ 90%, 15 g of raw Chinese yam, peeled and sliced, pulverized after drying, 10 g of euryale ferox, shelled, pulverized after stir-frying, 6 g of dried tangerine peel, pulverized after drying, 5 g of chicken gizzard-membrane, pulverized after processing by sand roasting method, 8 g of stir-fried malt, pulverized after stir-frying until slightly yellowish, 8 g of stir-fried hawthorn, pulverized after stir-frying until charred, 10 g of polygonatum sibiricum, sliced after steaming and drying nine times, 15 g of astragalus membranaceus, sliced after honey roasting, 6 g of wild jujube seed, pulverized after stir-frying, 5 g of lotus leaf, shredded after drying in the shade, 8 g of honeysuckle flower, unopened flower buds, dried, 3 g of mint, pulverized after drying in the shade, 6 g of chrysanthemum, Hangzhou white chrysanthemum, dried, 2 g of earthworm peptide, freeze-dried powder, molecular weight ≤ 2000 Da, 6 g of angelica sinensis, sliced after wine roasting, 5 g of platycodon grandiflorum, dried after peeling, 6 g of semen alpiniae oxyphyllae, pulverized after salt roasting, 10 g of codonopsis pilosula, sliced after honey roasting, 8 g of cistanche deserticola, sliced after steaming with wine.

[0025] Step 1: Pretreatment of medicinal materials. Weigh the medicinal materials except albumin peptide according to the ratio, mix them and pulverize them into 20-mesh coarse powder.

[0026] Step 2: Water decoction extraction. Add 10 times the amount (total weight of medicinal materials × 10) of purified water, decoct for 3 times, 1.5 hours each time.

[0027] After the first decoction, filter and retain the medicinal liquid; add 8 times the amount of water to the medicinal residue for the second decoction, filter; add 6 times the amount of water for the third decoction, and combine the filtrates of the three times.

[0028] Step 3: Concentration. Concentrate the combined filtrates under vacuum (60 °C) to a relative density of 1.20 (measured at 60 °C) to obtain an extract.

[0029] Step 4: Mixing and drying. Add albumin peptide to the extract, stir until completely dissolved, and pass through a 200-mesh sieve.

[0030] Freeze-drying process: Pre-freeze to -50 °C, vacuum degree ≤ 5 Pa, dry for 36 hours to obtain freeze-dried powder;

[0031] Or spray-drying process: Inlet air temperature 175 °C, outlet air temperature 80 °C, to obtain 200-mesh powder.

[0032] Step 5: Sub-packaging and sterilization. Sub-package the powder into 50 g / bag (each bag contains 45 g of medicinal material extract + 5 g of albumin peptide), and sterilize by cobalt-60 irradiation (dose 8 kGy).

[0033] Quality inspection results:

[0034]

[0035] Experimental design: Select 60 SPF-grade mice, randomly divide them into a control group (normal saline), a comparison group (commercially available immunomodulator), and an example group (administer 0.5 g / kg of this product by gavage daily), and continuously administer the drug for 28 days.

[0036] Results:

[0037] Immune index: The IgG content in the serum of the mice in the experimental group increased by 35% (the control group increased by 18%);

[0038] Anti-fatigue test: The swimming time was prolonged by 42% (the control group was prolonged by 25%);

[0039] Gastrointestinal function: The gastric emptying rate increased by 28% (the control group increased by 12%).

[0040] Product form and instructions for use:

[0041] Form: Light yellow to brownish-yellow powder, with a fragrant smell of medicinal materials, and forms a uniform suspension after brewing;

[0042] Usage: 1 packet per day, brew with warm water and take after meals;

[0043] Storage: Keep sealed and away from light. Below 25°C. Use up within 7 days after opening.

[0044] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made therein without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine beverage composition for improving sub-health, characterized in that, It is composed of the following raw materials in parts by weight: albumin peptide 1 - 100 g, fresh Chinese yam 1 - 100 g, Gorgon fruit 1 - 100 g, dried tangerine peel 1 - 100 g, chicken gizzard-membrane 1 - 100 g, stir-fried malt 1 - 100 g, stir-fried hawthorn 1 - 100 g, polygonatum 1 - 100 g, astragalus membranaceus 1 - 100 g, wild jujube seed 1 - 100 g, lotus leaf 1 - 100 g, honeysuckle flower 1 - 100 g, mint 1 - 100 g, chrysanthemum 1 - 100 g, earthworm peptide 1 - 100 g, Chinese angelica 1 - 100 g, platycodon grandiflorum 1 - 100 g, semen alpiniae oxyphyllae 1 - 100 g, codonopsis pilosula 1 - 100 g, desertliving cistanche 1 - 100 g.

2. A traditional Chinese medicine beverage composition for improving sub-healthy state, characterized in that, It is composed of the following raw materials in parts by weight: albumin peptide 1 - 50 g, fresh Chinese yam 5 - 20 g, Gorgon fruit 3 - 15 g, dried tangerine peel 2 - 10 g, chicken gizzard-membrane 1 - 8 g, stir-fried malt 3 - 12 g, stir-fried hawthorn 2 - 10 g, polygonatum 5 - 15 g, astragalus membranaceus 5 - 20 g, wild jujube seed 3 - 10 g, lotus leaf 2 - 8 g, honeysuckle flower 3 - 12 g, mint 1 - 5 g, chrysanthemum 2 - 10 g, earthworm peptide 0.5 - 5 g, Chinese angelica 3 - 10 g, platycodon grandiflorum 2 - 8 g, semen alpiniae oxyphyllae 3 - 10 g, codonopsis pilosula 5 - 15 g, desertliving cistanche 3 - 12 g.

3. The traditional Chinese medicine beverage composition according to claim 1, wherein: The dosage of the albumin peptide is 10 - 30 g, the dosage of the astragalus membranaceus is 10 - 15 g, and the dosage of the codonopsis pilosula is 8 - 12 g.

4. A preparation method of the traditional Chinese medicine beverage composition according to any one of claims 1-3, characterized in that It includes the following steps: (1) Mix the medicinal materials except the albumin peptide in proportion, add 8 - 12 times the amount of water, decoct 2 - 3 times, each time for 1 - 2 hours; (2) Combine the decoction liquids and concentrate them into an extract with a relative density of 1.10 - 1.25 at 60 °C; (3) Add the albumin peptide to the extract and mix evenly, and make it into a powder of 100 - 200 meshes by freeze-drying or spray-drying; (4) Pack the powder into 50 g / bags and carry out irradiation sterilization.

5. The preparation method according to claim 4, characterized in that: The conditions for the freeze-drying are that the pre-freezing temperature ≤ -45 °C, the vacuum degree ≤ 10 Pa, and the drying time is 24 - 48 hours.

6. The preparation method according to claim 4, characterized in that: The inlet air temperature for the spray-drying is 160 - 180 °C, and the outlet air temperature is 70 - 90 °C.

7. Use of the traditional Chinese medicine beverage composition according to any one of claims 1 - 3 in the preparation of a drug or health product for regulating immunity and improving the sub-healthy state.

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