Nitric oxide release composition, release device, release system and release flow control method thereof

Abstract

The invention provides a nitric oxide release composition, a release device, a release system and a release flow control method thereof, and relates to the technical field of nitric oxide generation. The nitric oxide release device comprises a reaction container and a gas discharge unit. A liquid-phase reaction solution is contained in the reaction container, meanwhile, a solid-phase raw material adding opening is formed in the reaction container, and the solid-phase raw material adding opening is closed when solid-phase adding is not executed; after the solid-phase raw material is added, the solid-phase raw material reacts with the liquid-phase reaction solution to generate NO gas, and then the NO gas is discharged through a gas outlet pipeline arranged on the discharge unit, so that the generating and releasing device for preparing NO in a passive mode is obtained. According to the release system comprising the nitric oxide release device, the gas storage unit, the gas conveying unit and the control unit in the release system are arranged, so that the flow control in the NO gas wound sweeping and blowing process can be improved, the management of a patient in the treatment process is simplified, and the burden of a doctor is relieved.

Description

Technical Field

[0001] The present invention relates to the technical field of nitric oxide generation, and particularly to a nitric oxide release composition, a release device, a release system and a release flow control method thereof. Background Art

[0002] Nitric oxide gas plays a role in transmitting important messages and regulating cell functions in the human body, and can help promote blood circulation in the body. Existing research shows that NO can improve the healing of skin wounds and has a promoting effect on various chronic old and non-healing wounds caused by microcirculation disorders and infections.

[0003] Generally, NO can be instantaneously prepared by active or passive methods. Active methods such as electrochemistry and arc method control through a series of components powered on to quantitatively produce the required nitric oxide gas according to demand; passive methods such as nitrite + acid, GSNO + water, etc. generate NO gas through the spontaneous reaction of chemical substances. The advantage of the active method is that the generation of NO is flexibly controllable, but usually the equipment is large in volume and high in cost, which limits its application in some scenarios. The passive method has no such disadvantages, but it is not as good as the active method in generation control.

[0004] During the process of wound treatment, a certain dose of NO gas needs to be continuously provided to the wound. In order to improve the utilization rate, it is necessary to make the air flow aim at the wound as much as possible, and the single treatment process needs to last about 10 - 15 minutes. Due to the long treatment time, in order to take care of the patient's experience, the patient is generally not fixed during the treatment. This requires the operator to continuously observe and prompt the patient to adjust the posture during the treatment.

[0005] Therefore, in order to effectively apply the passive NO generation method to wound treatment, it is very necessary and urgent to develop and propose a new type of nitric oxide release system.

[0006] In view of this, the present invention is specifically proposed. Summary of the Invention

[0007] The object of the present invention is to provide a nitric oxide release device and a nitric oxide release system including the same, and the nitric oxide release system can orderly and controllably release the NO gas prepared by the passive method to better apply to the wound treatment of NO gas.

[0008] In order to achieve the above object of the present invention, the following technical solutions are specifically adopted:

[0009] The nitric oxide release composition provided by the present invention includes a NO donor source and a liquid-phase reaction solution, wherein:

[0010] The liquid phase reaction solution is mainly composed of an acid source and a catalyst, and the pH value of the liquid phase reaction solution is 4 to 5;

[0011] The NO donor source is solid phase nitrite.

[0012] Further, the acid source includes any one of citric acid, nicotinic acid, and malic acid, preferably citric acid;

[0013] The catalyst comprises ascorbic acid or an ascorbate, preferably ascorbic acid;

[0014] The solid phase nitrite includes any one of sodium nitrite, calcium nitrite and potassium nitrite, preferably sodium nitrite;

[0015] Preferably, the solid phase nitrite is in the form of tablets or capsules.

[0016] Furthermore, the mass ratio of the acid source, the catalyst and the NO donor source is 1-100:1-100:1-100;

[0017] Preferably, the mass ratio of the acid source, the catalyst and the NO donor source is 1-10:1-10:1-10.

[0018] The present invention provides a nitric oxide release device, which comprises a reaction container and a gas exhaust unit, wherein:

[0019] The reaction container is used to contain the liquid phase reaction solution, and a solid phase raw material addition port is provided on the reaction container, and the solid phase raw material addition port is used to add the NO donor source into the reaction container;

[0020] The gas exhaust unit comprises a gas outlet pipeline, which is connected to the reaction container and is used for exhausting NO gas released from the reaction container.

[0021] Furthermore, a one-way valve for NO gas output is provided on the gas outlet pipeline;

[0022] And / or, the gas outlet pipeline is provided with a hydrophobic filter membrane for filtering water in the NO gas;

[0023] Preferably, the hydrophobic filter membrane on the air outlet pipeline is arranged upstream of the one-way valve.

[0024] The present invention provides a nitric oxide release system, which comprises: a nitric oxide release device, a gas storage unit and a gas delivery unit;

[0025] The nitric oxide release device is the nitric oxide release device described above;

[0026] The gas storage unit comprises a gas storage container and a gas storage pipeline;

[0027] The gas delivery unit includes a gas delivery pipeline and a mass flow controller provided on the gas delivery pipeline;

[0028] The gas outlet pipeline of the nitric oxide release device is connected to the gas storage pipeline of the gas storage unit and the gas delivery pipeline of the gas delivery unit through a tee.

[0029] Further, a back pressure valve is provided on the gas storage container;

[0030] And / or, a gas supply pipeline is provided on the gas storage container, and a driving pump and a gas supply pipeline filter membrane are provided on the gas supply pipeline.

[0031] Further, a filter is also provided on the gas delivery pipeline, and the filter is provided upstream of the mass flow controller.

[0032] Further, a treatment chamber is also provided in the nitric oxide release system;

[0033] The treatment chamber is communicated with the gas delivery pipeline, and a camera and a sweeping and blowing device are provided in the treatment chamber.

[0034] Further, a control unit is also provided in the nitric oxide release system; the control unit is signal-connected to the driving pump on the gas storage container, the mass flow controller on the gas delivery pipeline, the camera and the sweeping and blowing device in the treatment chamber.

[0035] The nitric oxide release flow control method provided by the present invention is realized based on the above-mentioned nitric oxide release system.

[0036] Compared with the prior art, the beneficial effects of the present invention are:

[0037] The nitric oxide release device provided by the present invention includes a reaction vessel and a gas discharge unit. A liquid-phase reaction solution is contained inside the reaction vessel; a solid-phase raw material addition port is provided on the reaction vessel, and this solid-phase raw material addition port is closed when no solid-phase addition action is performed; when the solid-phase raw material is added, NO gas is generated in the reaction vessel; at the same time, an air outlet pipeline is provided on the gas discharge unit of the present application, and the air outlet pipeline is communicated with the reaction vessel for discharging the NO gas released in the reaction vessel, thereby obtaining a production and release device for preparing NO in a passive manner.

[0038] The nitric oxide release system provided by the present invention mainly consists of the above-mentioned nitric oxide release device, gas storage unit and gas delivery unit, wherein: the gas storage unit includes a gas storage container and a gas storage pipeline; the gas delivery unit includes a gas delivery pipeline and a mass flow controller provided on the gas delivery pipeline; the gas outlet pipeline of the nitric oxide release device is connected to the gas storage pipeline of the gas storage unit and the gas delivery pipeline of the gas delivery unit through a tee. The NO gas generated and released by the nitric oxide release device of the present application is stored in the gas storage unit through the tee. When NO gas needs to be released, the NO gas is input into the gas delivery unit through the tee for release. Further, the nitric oxide release system of the present invention is also provided with a control unit, which is signal-connected to the drive pump on the gas storage container, the mass flow controller on the gas delivery pipeline, the camera and the sweeping device in the treatment chamber. By inputting and feedback-adjusting the above signals, the flow control during the NO gas wound surface sweeping process is adjusted, thereby simplifying the management of the patient treatment process and reducing the burden on doctors. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0040] Figure 1 FIG. is a schematic structural diagram of the nitric oxide release device provided in Embodiment 1 of the present invention;

[0041] Figure 2 FIG. is a schematic structural diagram of the reaction container and the gas discharge unit in the nitric oxide release device provided in Embodiment 1 of the present invention;

[0042] Figure 3 FIG. is a schematic structural diagram of the nitric oxide release system provided in Embodiment 2 of the present invention;

[0043] Figure 4 FIG. is a schematic structural diagram of the nitric oxide release system provided in Embodiment 2 of the present invention;

[0044] Figure 5 FIG. is a schematic structural diagram of a filter provided on the gas delivery pipeline in Embodiment 2 of the present invention.

[0045] Icon: 1 - Nitric oxide releasing device; 11 - Reaction vessel; 12 - Gas discharge unit; 111 - Solid-phase raw material addition port; 121 - Gas outlet pipeline; 1211 - Check valve; 1212 - Hydrophobic filter membrane; 2 - Gas storage unit; 3 - Gas delivery unit; 21 - Gas storage container; 22 - Gas storage pipeline; 31 - Gas delivery pipeline; 32 - Mass flow controller; 211 - Back pressure valve; 2111 - Driving pump; 2112 - Gas supply pipeline filter membrane; 311 - Filter; 4 - Treatment chamber; 41 - Camera. Detailed implementation mode

[0046] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work belong to the scope of protection of the present invention. To help understand the present invention more clearly, the present invention will be introduced in detail through specific embodiments.

[0047] In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0048] Embodiment 1

[0049] Figure 1 It is a schematic structural diagram of the nitric oxide releasing device 1 provided in this embodiment.

[0050] Figure 2 It is a specific structural schematic diagram of the reaction vessel 11 and the gas discharge unit 12 in the nitric oxide releasing device 1 provided in this embodiment.

[0051] See Figure 1 、 Figure 2 A nitric oxide releasing device 1 provided in this embodiment, the nitric oxide releasing device 1 includes a reaction vessel 11 and a gas discharge unit 12, wherein:

[0052] The reaction vessel 11 is used to contain a liquid-phase reaction solution, and a solid-phase raw material addition port 111 is provided on the reaction vessel 11, and the solid-phase raw material addition port 111 is used to put the NO donor source into the reaction vessel 11;

[0053] The gas discharge unit 12 includes an air outlet pipeline 121, and the air outlet pipeline 121 is connected to the reaction vessel 11 for discharging the NO gas released from the reaction vessel 11.

[0054] The nitric oxide releasing device 1 provided in this embodiment includes a reaction vessel 11 and a gas discharge unit 12. The reaction vessel 11 is filled with a liquid-phase reaction solution inside; a solid-phase raw material addition port 111 is provided on the reaction vessel 11, and the solid-phase raw material addition port 111 is closed when the solid-phase addition action is not performed; when the solid-phase raw material is added, NO gas is generated in the reaction vessel 11; at the same time, an air outlet pipeline 121 is provided on the gas discharge unit 12 of the present application, and the air outlet pipeline 121 is connected to the reaction vessel 11 for discharging the NO gas released from the reaction vessel 11, thereby obtaining a generation and release device for preparing NO in a passive manner.

[0055] In a preferred embodiment of this embodiment, the volume of the reaction vessel 11 is 300 ml to 2 L.

[0056] In a preferred embodiment of this embodiment, the liquid-phase reaction solution mainly consists of an acid source and a catalyst, and the pH value of the liquid-phase reaction solution is 4 to 5;

[0057] In the above preferred embodiment, the NO donor source includes nitrite, the NO donor source is a solid-phase nitrite raw material, and the solid-phase nitrite raw material is a solid-phase sodium nitrite tablet or capsule.

[0058] In the above preferred embodiment, the acid source is citric acid; the catalyst is ascorbic acid;

[0059] The preparation method of the liquid-phase reaction solution in this embodiment includes: weighing 5 parts of nitrite, 100 parts of water, and 3.5 parts of citric acid by mass, and then fully dissolving and mixing them; then adding ascorbic acid until the pH of the solution is 4.5 to obtain the liquid-phase reaction solution.

[0060] In a preferred embodiment of this embodiment, a one-way valve 1211 for NO gas output is provided on the air outlet pipeline 121;

[0061] As a preferred embodiment, the one-way valve 1211 provided on the air outlet pipeline 121 can achieve single-phase output of NO gas and prevent the gas in the gas storage pipeline 22 from flowing back to the reaction vessel 11.

[0062] In a preferred embodiment of this embodiment, a hydrophobic filter membrane 1212 for filtering moisture in the NO gas is provided on the air outlet pipeline 121;

[0063] As a preferred embodiment, the hydrophobic filter membrane 1212 can effectively filter the moisture output with the NO product gas.

[0064] In a preferred embodiment of this embodiment, the hydrophobic filter membrane 1212 on the outlet pipeline 121 is arranged upstream of the one-way valve 1211.

[0065] Embodiment 2

[0066] Figure 3 is a schematic structural diagram of the nitric oxide release system provided in this embodiment;

[0067] Figure 4 is a specific structural schematic diagram of the nitric oxide release system provided in this embodiment.

[0068] See Figure 3 、 Figure 4 , a nitric oxide release system, the nitric oxide release system includes: a nitric oxide release device 1, a gas storage unit 2 and a gas delivery unit 3;

[0069] The gas storage unit 2 includes a gas storage container 21 and a gas storage pipeline 22;

[0070] The gas delivery unit 3 includes a gas delivery pipeline 31 and a mass flow controller 32 arranged on the gas delivery pipeline 31;

[0071] The outlet pipeline 121 of the nitric oxide release device 1 is connected to the gas storage pipeline 22 of the gas storage unit 2 and the gas delivery pipeline 31 of the gas delivery unit 3 through a tee.

[0072] The nitric oxide release system provided in this embodiment is mainly composed of a nitric oxide release device 1, a gas storage unit 2 and a gas delivery unit 3, wherein: the gas storage unit 2 includes a gas storage container 21 and a gas storage pipeline 22; the gas delivery unit 3 includes a gas delivery pipeline 31 and a mass flow controller 32 arranged on the gas delivery pipeline 31; the outlet pipeline 121 of the nitric oxide release device 1 is connected to the gas storage pipeline 22 of the gas storage unit 2 and the gas delivery pipeline 31 of the gas delivery unit 3 through a tee. The NO gas generated and released by the nitric oxide release device 1 of the present application is stored in the gas storage unit 2 through a tee. When NO gas needs to be released, the NO gas is input into the gas delivery unit 3 through the tee for release.

[0073] In a preferred embodiment of this embodiment, a back pressure valve 211 is provided on the gas storage container 21;

[0074] As a preferred embodiment, the back pressure valve 211 is used to discharge the excess gas after the internal pressure of the gas storage container 21 reaches the set value, avoiding excessive pressure in the system.

[0075] In a preferred embodiment of the present embodiment, an air supply pipeline is provided on the gas storage container 21, and a driving pump 2111 and an air supply pipeline filter membrane 2112 are provided on the air supply pipeline. The air supply pipeline is communicated with the gas storage container 21 and is used for supplementing air into the gas storage container 21.

[0076] Figure 5 Schematic structural diagram of a filter 311 provided on the delivery gas pipeline 31 provided in this embodiment.

[0077] See Figure 5 In a preferred embodiment of the present embodiment, a filter 311 is further provided on the delivery gas pipeline 31. The filter 311 is provided upstream of the mass flow controller 32 and is used for converting NO2 (NO is easily converted to NO2 when contacting air) in the output gas into NO.

[0078] Preferably, the filter 311 is filled with particles loaded with VC to reduce NO2 to NO.

[0079] In a preferred embodiment of the present embodiment, the nitric oxide release system further includes a treatment chamber 4 for accommodating the affected part of the patient (such as the foot). Above the interior of the treatment chamber, there is a camera for capturing image information of the patient's wound surface.

[0080] In the above preferred embodiment, the treatment chamber 4 is communicated with the delivery gas pipeline 31, and a camera 41 and a sweeping and blowing device are provided in the treatment chamber 4.

[0081] It should be noted that the working process and principle of the nitric oxide release system of the present application include:

[0082] S1. Gas preparation:

[0083] 1. First, open the solid-phase raw material addition port 111 of the nitric oxide release device 1, put the solid-phase sodium nitrite tablet or capsule into the reaction container 11, and close the solid-phase raw material addition port 111; at this time, the mass flow controller 32 is in the closed state;

[0084] 2. The solid-phase sodium nitrite tablet or capsule gradually dissolves in the liquid-phase reaction solution in the reaction container 11, and the NO donor source inside starts to react when contacting the liquid, continuously generating NO gas (product gas); the product gas passes through the hydrophobic filter membrane 1212 and the one-way valve 1211 in sequence. Since the mass flow controller 32 is closed, the product gas enters the gas storage container 21 for temporary storage;

[0085] 3. As the product gas continuously enters the gas storage container 21, the internal pressure of the gas storage container 21 gradually increases. (When the set pressure of the back pressure valve 211 is reached, the excess gas is discharged through the back pressure valve 211.) After the internal pressure of the gas storage container 21 reaches the threshold A, it enters the control release stage;

[0086] S2. Preset:

[0087] Operate the camera 41 in the treatment chamber 4 to align the camera 41 with the wound surface of the patient's affected area in the treatment chamber 4, and set the purge flow rate, purge time, etc. on the display;

[0088] It should be noted that there is no strict sequence between the above-mentioned S1 gas preparation and S2 presetting. They can be carried out simultaneously, or the presetting can be done first and then the gas preparation, or the gas preparation can be done first and then the presetting.

[0089] S3. Control release:

[0090] Through the camera 41 and the algorithm, detect and identify the position of the wound surface and make corresponding adjustments to the release flow rate, or remind the patient; during the control release stage of NO gas, the drive pump 2111 on the gas storage container 21 is started. On the one hand, it provides power for the product gas to be transported to the treatment chamber 4, and on the other hand, it dilutes the product gas.

[0091] In a preferred implementation manner of this embodiment, the nitric oxide release system is further provided with a control unit; the control unit is signal-connected to the drive pump 2111 on the gas storage container 21, the mass flow controller 32 on the delivery gas pipeline 31, the camera 41 in the treatment chamber 4, and the blowing device.

[0092] It should be noted that the control method of the control unit for the NO gas release flow rate in the nitric oxide release system of the present application includes:

[0093] 1. The camera 41 is aligned with the patient's wound surface. The operator selects the corresponding wound surface and adjusts an appropriate threshold. At this time, a contour mark is displayed on the target wound surface in the display; the size of the wound surface is displayed as "--", indicating that the accurate value has not been measured yet.

[0094] 2. Place the "calibration card" at the same distance as the wound surface and parallel to the wound surface. The display synchronously displays the position of the "calibration card" and prompts the operator to confirm. When the operator clicks OK, the display shows the contour and area of the target wound surface. The "calibration card" is a card with a specific area that can be recognized by the system.

[0095] 3. After the area of the wound surface is displayed, the system prompts the operator with a specific purge flow rate and purge time. The operator can modify it according to the actual situation. After confirmation, the system starts to purge the wound surface and times.

[0096] 4. During the purging process, the position and distance of the wound surface are detected in real time. When the wound surface moves within a reasonable distance range, the purging flow rate is automatically adjusted. When it exceeds a specific threshold, the patient is prompted to make appropriate fine-tuning to ensure the purging effect.

[0097] Specifically, the algorithms for calculating the wound surface area include:

[0098] 1. Considering the physiological characteristics of the human eye, the following formula is used to perform gray-scale processing on the image to convert the image into a gray-scale image.

[0099] Gray = 0.299R + 0.587G + 0.114B, where R, G, and B are the values of the red, green, and blue components in the acquired image, and Gray is the gray-scale value.

[0100] 2. Perform Gaussian filtering on the image, that is, perform weighted averaging according to the gray-scale values of the pixel points to be filtered and their neighboring points according to certain parameter rules, effectively filtering out the high-frequency noise superimposed in the ideal image.

[0101] 3. Edge selection and contour extraction. Here, the most suitable contour is selected in an artificial intervention manner; by the user setting a threshold, the system performs image binarization through this threshold for edge recognition, and then performs a contour extraction algorithm, and then draws the contour of the wound through this contour and displays it to the operator; the operator can select the most suitable wound contour by setting different thresholds.

[0102] 4. Obtain the wound surface area by calculating the number of pixel points within the contour.

[0103] 5. Obtain the actual area of the wound surface by comparing with the pixels of the calibration card.

[0104] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A nitric oxide-releasing composition, characterized in that, The nitric oxide releasing composition comprises a NO donor source and a liquid-phase reaction solution, wherein: The liquid-phase reaction solution mainly consists of an acid source and a catalyst, and the pH value of the liquid-phase reaction solution is 4-5; The NO donor source is a solid-phase nitrite.

2. The nitric oxide-releasing composition according to claim 1, wherein The acid source includes any one of citric acid, nicotinic acid, and malic acid, preferably citric acid; The catalyst includes ascorbic acid or ascorbate, preferably ascorbic acid; The solid-phase nitrite includes any one of sodium nitrite, calcium nitrite, and potassium nitrite, preferably sodium nitrite; Preferably, the solid-phase nitrite is in the form of tablets or capsules.

3. The nitric oxide releasing composition according to claim 1, characterized in that, The mass ratio of the acid source, the catalyst, and the NO donor source is 1-100:1-100:1-100; Preferably, the mass ratio of the acid source, the catalyst, and the NO donor source is 1-10:1-10:1-10.

4. A nitric oxide releasing device, characterized in that, The nitric oxide releasing device (1) comprises a reaction container (11) and a gas discharge unit (12), wherein: The reaction container (11) is used for containing the liquid-phase reaction solution according to any one of claims 1-3. A solid-phase raw material addition port (111) is provided on the reaction container (11), and the solid-phase raw material addition port (111) is used for putting the NO donor source according to any one of claims 1-3 into the reaction container (11); The gas discharge unit (12) includes an air outlet pipeline (121). The air outlet pipeline (121) is connected to the reaction container (11) and is used for discharging the NO gas released in the reaction container (11).

5. The nitric oxide releasing device according to claim 4, characterized in that, A one-way valve (1211) for NO gas output is provided on the air outlet pipeline (121); and / or, a hydrophobic filter membrane (1212) for filtering moisture in the NO gas is provided on the air outlet pipeline (121); and / or, the hydrophobic filter membrane (1212) on the air outlet pipeline (121) is arranged upstream of the one-way valve (1211).

6. A nitric oxide releasing system, characterized in that, The nitric oxide releasing system includes: a nitric oxide releasing device (1), a gas storage unit (2), and a gas delivery unit (3); The nitric oxide releasing device (1) is the nitric oxide releasing device (1) according to claim 4 or 5; The gas storage unit (2) includes a gas storage container (21) and a gas storage pipeline (22); The gas delivery unit (3) includes a gas delivery pipeline (31) and a mass flow controller (32) provided on the gas delivery pipeline (31); The air outlet pipeline (121) of the nitric oxide releasing device (1) is connected to the gas storage pipeline (22) of the gas storage unit (2) and the gas delivery pipeline (31) of the gas delivery unit (3) through a tee pipe.

7. The nitric oxide releasing system according to claim 6, wherein A back pressure valve (211) is provided on the gas storage container (21); and / or, a gas supply pipeline is provided on the gas storage container (21), and a driving pump (2111) and a gas supply pipeline filter membrane (2112) are provided on the gas supply pipeline; and / or, a filter (311) is further provided on the gas delivery pipeline (31), and the filter (311) is arranged upstream of the mass flow controller (32).

8. The nitric oxide releasing system according to claim 6, wherein The nitric oxide releasing system is further provided with a treatment chamber (4); The treatment chamber (4) is communicated with the delivery gas pipeline (31), and a camera (41) and a sweeping and blowing device are arranged in the treatment chamber (4).

9. The nitric oxide releasing system according to claim 6, wherein, The nitric oxide release system is further provided with a control unit; The control unit is in signal connection with the driving pump (2111) on the gas storage container (21); The control unit is in signal connection with the mass flow controller (32) on the delivery gas pipeline (31); The control unit is in signal connection with the camera (41) and the sweeping and blowing device in the treatment chamber (4).

10. A method for controlling the release flow rate of nitric oxide, characterized in that, The release flow control method performs nitric oxide release based on the nitric oxide release system according to any one of claims 6 to 9.

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