N-gamma mixed radiation field dose self-discrimination detection method and system based on SERS (Surface Enhanced Raman Scattering) technology

Abstract

The invention discloses an n-gamma mixed radiation field dose self-discrimination detection method and system based on an SERS (Surface Enhanced Raman Scattering) technology, and relates to the technical field of nuclear radiation detection. The method comprises the following steps: co-modifying an SERS substrate with neutron sensitive molecules and gamma ray sensitive molecules with SERS characteristic fingerprints free of crosstalk, so as to obtain a radiation sensitive molecule functionalized SERS substrate; and transferring the substrate to a solid-phase substrate by using an interface self-assembly technology to obtain the SERS chip with independent dose response to the n-gamma mixed radiation field. Fitting the neutron dose and the gamma dose through the relative intensity of the SERS characteristic peak position to obtain a response function, and scaling the SERS chip; the method comprises the following steps: measuring an optical signal of an SERS chip by using a Raman spectrometer, extracting SERS spectral feature information, and carrying out inversion to obtain a neutron dose and a gamma dose so as to realize self-discrimination and sensitive detection of the dose of an n-gamma mixed radiation field; the method solves the problems of mutual interference, insufficient sensitivity and the like in the traditional technology, and has important application value in the field of nuclear radiation detection.

Description

Technical Field

[0001] The present invention relates to the technical field of nuclear radiation detection, and in particular to a method and system for self-discriminating detection of the dose of an n-γ mixed radiation field based on SERS technology. Background Technique

[0002] In the fields of nuclear energy and nuclear technology applications such as nuclear facility operation, nuclear waste disposal, nuclear medicine diagnosis and treatment, nuclear emergency, and manned spaceflight, neutrons and gamma rays often coexist, thus forming an n-γ mixed radiation field. Neutrons and gamma rays have different physical properties, resulting in differences in their radiation biological effects. Accurately measuring the neutron dose and gamma ray dose in the n-γ mixed radiation field is an important basis for ensuring the health of workers and the public and optimizing radiation protection measures.

[0003] At present, the conventional technical means for measuring the dose of the n-γ mixed radiation field is based on the interaction characteristics of radiation and matter. Two dosimeters with significantly different responses to radiation (one that responds to both neutrons and gamma rays, and the other that only responds to gamma rays) are selected and used in a paired combination, such as paired thermoluminescent dosimeters or paired ionization chamber dosimeters, etc. Then, through the differential measurement method, the neutron dose and gamma dose in the mixed radiation field can be determined respectively. The main limitations of this technology are: (1) The structure of the dosimeter is not compact enough, resulting in limited applicability in a narrow space; (2) The measurement process takes a long time, affecting the overall measurement efficiency; (3) The volume of the signal readout device is large, making it difficult to achieve portable measurement.

[0004] Surface Enhanced Raman Scattering (SERS) technology is a new "molecular fingerprint spectrum" technology that can detect and image at the single molecule level, with an intrinsic enhancement factor as high as 10 14 -10 15, due to its high sensitivity and molecular fingerprint specificity, it has broad application prospects in analytical characterization and sensor detection. SERS technology has been applied in single type of radiation detection (such as Journal of Raman Spectroscopy, 2018, 49 (7): 1190-1197; Journal of Radiation Research and Radiation Processing, 2019, 37 (4): 040701, etc.). However, compared with single neutron or gamma dose measurement, n-γ mixed radiation field dose measurement requires higher accuracy. It is necessary to strictly select radiation-sensitive molecules with intrinsic molecular fingerprints and no crosstalk, and improve the signal reproducibility of the SERS substrate to avoid interference caused by the interaction between the two rays and the SERS substrate, resulting in spectral signal superposition. Therefore, there has been no report on mixed field detection based on SERS technology. At present, how to achieve self-discrimination and efficient detection of n-γ mixed radiation field dose and meet the needs of miniaturization and portability is still a technical problem that needs to be solved in this field. Summary of the invention

[0005] In view of the above technical difficulties, the purpose of the present invention is to provide a method and system for self-discrimination detection of n-γ mixed radiation field dose based on SERS technology. The method uses surface enhanced Raman scattering (SERS) technology with high sensitivity, molecular fingerprint recognition and rapid non-destructive measurement capabilities as the detection technology, and uses radiation-sensitive molecules with non-overlapping SERS characteristic peaks as the detection medium. By measuring the SERS spectrum before and after irradiation with the mixed radiation field and extracting and analyzing the characteristic information, the method can achieve simultaneous and efficient self-discrimination detection of the n-γ mixed radiation field dose.

[0006] Specifically, the above invention object is achieved through the following technical solutions:

[0007] First, the present application provides a method for self-discrimination detection of n-γ mixed radiation field dose based on SERS technology, comprising the following steps:

[0008] 1) Preparation of radiation-sensitive molecule functionalized SERS substrate: neutron-sensitive molecules and gamma-ray-sensitive molecules are dispersed in a good solvent, mixed with a noble metal sol-type SERS substrate, stirred and reacted at room temperature for 24 hours, then centrifuged three times and resuspended in ultrapure water to complete the purification process, thereby obtaining a SERS substrate co-modified with neutron-sensitive molecules and gamma-ray-sensitive molecules;

[0009] 2) Preparation of a SERS chip with independent dose response to n-γ mixed radiation field: pre-treating the solid substrate with Piranha solution for 1 hour, then rinsing with ultrapure water, and drying at room temperature to obtain a hydrophilic solid substrate for standby use;

[0010] Hexane was added to the radiation-sensitive molecule-functionalized SERS substrate obtained in step 1) to form a water / hexane interface. Then, ethanol was dropped into it at a constant rate using a syringe pump until the dropping was stopped when a metallic luster appeared at the water / hexane interface. After the hexane evaporated and a continuous bright film floated on the water surface, a hydrophilic solid substrate was placed above the film and contacted with it, so that the radiation-sensitive molecule-functionalized SERS substrate array was transferred to the solid substrate. After drying at room temperature, an SERS chip was obtained;

[0011] The above film is a tightly packed array formed by self-assembly of the functionalized SERS substrate as the basic unit at the interface. Compared with the liquid-phase colloidal SERS substrate, the advantages of this film are: a) It can be transferred to the surface of a rigid or flexible solid substrate to form a solid-phase SERS substrate, with higher storage stability and more convenient use (easy to integrate on the surface of the object to be detected; compatible with a portable Raman spectrometer and can be directly detected); b) The signal uniformity of the SERS array is better, which is beneficial to improving the detection accuracy.

[0012] 3) Calibrate the SERS chip: Place the SERS chip prepared in step 2) under a standard neutron source and a gamma-ray source and irradiate it with different doses. Use a Raman spectrometer to measure the SERS spectrum of the SERS chip after irradiation; Based on the molecular structure transformation of the radiation-sensitive molecule under irradiation conditions, select characteristic peak positions for quantitative analysis, and fit the neutron dose and gamma dose using the relative intensities of the characteristic peak positions to obtain the dose response functions of the SERS chip for neutrons and gamma rays, so as to calibrate the SERS chip and obtain an SERS chip with an independent dose response; After calibration, the correlation coefficients of the neutron dose response function and the gamma-ray dose response function are both greater than 0.95;

[0013] 4) Measure the optical signal of the SERS chip: Place the calibrated SERS chip in an n-γ mixed radiation field for irradiation. After the irradiation is completed, take it out and place the irradiated SERS chip on a Raman spectrometer to measure the SERS spectrum;

[0014] 5) Read out the radiation dosimetry information contained in the SERS chip: Extract the characteristic information of the SERS spectrum obtained in step 4) and substitute it into the neutron and gamma-ray dose response functions obtained in step 3) to invert the neutron dose and gamma-ray dose, so as to realize the self-discrimination of the n-γ mixed radiation field.

[0015] Preferably, the SERS characteristic peak positions of the neutron-sensitive molecule and the gamma-ray-sensitive molecule in step 1) do not overlap before and after irradiation, and the neutron-sensitive molecule has gamma-radiation stability. Preferably, the neutron-sensitive molecule is 4-mercaptobenzeneboronic acid pinacol ester, the gamma-ray-sensitive molecule is glutathione, its good solvent is water or ethanol, and the dispersion concentration is 0.1-1 mM; the noble metal sol-type SERS substrate is a noble metal nanoparticle sol with a particle diameter of 30-100 nm; in the above substrate, the noble metal nanoparticle concentration is 0.02-0.5 μM, and its material includes gold nanoparticles, silver nanoparticles or gold / silver composite nanoparticles, etc.; in terms of the molar mass ratio, neutron-sensitive molecule:noble metal sol-type SERS substrate, gamma-ray-sensitive molecule:noble metal sol-type SERS substrate are both greater than 100:1 (taking the noble metal molar content in the SERS substrate as "1"); the centrifugation speed is not less than 5000 rpm, and the single centrifugation time is 5-10 min.

[0016] Preferably, in step 2), the solid-phase substrate is any one of a silicon wafer, a glass slide, and a polydimethylsiloxane film. The thickness of the solid-phase substrate is 0.2-2 mm. The water contact angle of the prepared hydrophilic solid-phase substrate is <30°. The volume ratio of the radiation-sensitive molecule-functionalized SERS substrate to hexane is 4:1, and the dropping rate of ethanol is 0.2 mL / min (to ensure the formation of a continuous film on the substrate surface). The relative standard deviation (RSD) of the signal intensity of the SERS chip is ≤10%.

[0017] Preferably, in step 3), the same SERS chip is subjected to more than 10 SERS spectral measurements and the average value is taken; the neutron response characteristic peak position of the SERS chip corresponds to the characteristic wave number region where the boron-containing functional group is located before and after neutron irradiation, and the gamma-ray response characteristic peak position corresponds to the characteristic wave number region where the redox-active functional group is located before and after gamma-ray irradiation; the fitting method of the dose response function is the least squares method, and the correlation coefficient is greater than 0.95.

[0018] Preferably, the Raman spectrometer used in step 4) is a conventional commercially available instrument, such as the MiniRam type portable Raman spectrometer produced by B&W Tek Company in the examples.

[0019] Preferably, in step 5), the characteristic information of the SERS spectrum is the relative intensity change of the SERS characteristic peak positions caused by neutrons or gamma rays.

[0020] Secondly, the present invention further provides an n-γ mixed radiation field dose self-discriminating detection system based on SERS technology. The system includes a SERS chip with independent dose response to the n-γ mixed radiation field, a portable Raman spectroscopy acquisition module (i.e., a Raman spectrometer), a SERS spectral feature information extraction module, and a radiation dose information reading module. The SERS spectral feature information extraction module analyzes the selected feature information of the spectrum collected in step 4). The radiation dose information reading module is used to substitute the extracted feature information into the dose response function, convert it into radiation dose and read it out. The SERS chip is coupled with the portable Raman spectroscopy acquisition module through an optical fiber probe (such as the commercially available product BAC100B, B&W Tek). The portable Raman spectroscopy acquisition module, the SERS spectral feature information extraction module, and the radiation dose information reading module are connected through a conventional USB data transmission interface / data cable. Among them, the SERS chip is used to detect the dose of the n-γ mixed radiation field; the portable Raman spectroscopy acquisition module is used to quickly measure the SERS spectrum of the SERS chip to achieve miniaturization and portability; the SERS spectral feature information extraction module is used to extract and calculate the relative intensity of the characteristic peak positions of the SERS spectrum; the radiation dose information reading module is used to convert the SERS spectral feature information into n-γ mixed radiation field dose information to achieve self-discrimination of neutron dose and gamma ray dose.

[0021] Compared with the prior art, the beneficial technical effects of the n-γ mixed radiation field dose self-discriminating detection method and system based on SERS technology provided by the present invention are as follows:

[0022] (1) Integrate radiation-sensitive molecules with non-overlapping SERS characteristic peaks in one body. When measuring the mixed radiation field, it is not necessary to use dosimeters in pairs, and self-discriminating detection of neutron dose and gamma ray dose can be realized in a single dose, which is suitable for measuring neutron / gamma mixed radiation fields or neutrons or gamma rays; this system can improve the structural compactness, measurement efficiency and applicability of the dosimeter;

[0023] (2) The present application uses SERS technology with high sensitivity and molecular fingerprint recognition ability as the detection technology, which solves the problem of mutual interference in the detection of the n-γ mixed radiation field dose, resulting in difficult signal differentiation;

[0024] (3) The signal reading device uses a portable or handheld Raman spectrometer, which can meet the requirements of miniaturization (the volume is less than 1 / 5 of the volume of the existing detection instrument) and portable measurement. Description of the Drawings

[0025] Figure 1 It is a flowchart of the n-γ mixed radiation field dose self-discriminating detection method based on SERS technology in the present invention.

[0026] Figure 2 Schematic diagram of the n-γ mixed radiation field dose self-discrimination detection system based on SERS technology in the present invention;

[0027] Among them, 1 - n-γ mixed radiation field, 2 - SERS chip with independent dose response to n-γ mixed radiation field, 3 - optical coupling interface, 4 - portable Raman spectroscopy acquisition module, 5 - data transmission interface, 6 - SERS spectral feature information extraction module, 7 - data coupling interface, 8 - radiation dose information reading module.

[0028] Figure 3 SEM image of the SERS chip prepared in the embodiment of the present invention.

[0029] Figure 4 SERS spectrum of the SERS chip prepared in the embodiment of the present invention without irradiation. Detailed implementation manners

[0030] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings and embodiments. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of protection of the present invention.

[0031] Unless otherwise specified, the instruments or materials involved in the following embodiments are all obtained through commercial channels.

[0032] 4-Mercaptophenylboronic acid pinacol ester solution is purchased from Shanghai Macklin Biochemical Co., Ltd.;

[0033] Glutathione solution is purchased from Aladdin Reagent (Shanghai) Co., Ltd.;

[0034] Gold nanosol (gold nanoparticle diameter 60 nm) is purchased from Suzhou Beike Nano Technology Co., Ltd.;

[0035] Silicon wafers (20 mm × 20 mm × 0.725 mm) are purchased from Lijing Electronics Co., Ltd.;

[0036] Example 1

[0037] This example provides a method for self-discriminating the dose of the n-γ mixed radiation field based on SERS technology (as Figure 1 shown), including the following steps:

[0038] 1) Preparation of radiation-sensitive molecule-functionalized SERS substrate: Mix a solution of 4-mercaptobenzeneboronic acid pinacol ester (1 mM, 1 mL) and a solution of glutathione (1 mM, 1 mL) with nano-gold sol (1 μM, 5 mL), stir and react at room temperature for 24 h, then centrifuge three times at 8000 rpm (10 min each time) and resuspend in 4 mL of ultrapure water to complete the purification process and obtain a radiation-sensitive molecule-functionalized SERS substrate;

[0039] 2) Preparation of SERS chip with independent dose response to n-γ mixed radiation field: Pretreat a silicon wafer with Piranha solution (obtained by mixing concentrated sulfuric acid with a mass concentration of 98% and hydrogen peroxide solution with a mass concentration of 30% in a volume ratio of 7:3) for 1 h, then rinse with ultrapure water and dry at room temperature to obtain a hydrophilic silicon wafer substrate for standby;

[0040] Add hexane (1 mL) to the radiation-sensitive molecule-functionalized SERS substrate (4 mL) obtained in step 1) to form a water / hexane interface, then use a syringe pump to drop ethanol into it at a constant rate of 0.2 mL / min until the addition stops when a metallic luster appears at the water / hexane interface. After the hexane evaporates and a continuous bright film floats on the water surface, place the hydrophilic silicon wafer substrate above the film and make contact with it to transfer the radiation-sensitive molecule-functionalized SERS substrate array to the silicon wafer substrate, and dry at room temperature to obtain a SERS chip;

[0041] Figure 3 This is the SEM image of the SERS chip prepared in this step. The gold nanoparticles are densely arranged on the substrate with a uniform size distribution, indicating that the radiation-sensitive molecule-functionalized SERS substrate array is well transferred to the solid-phase substrate.

[0042] Figure 4 This is the SERS spectrum of the SERS chip (unirradiated) prepared in this step. It can be seen that the B-O related characteristic peaks of 4-mercaptobenzeneboronic acid pinacol ester appear at 1574 and 1585 cm -1 The S-H, C-S, O-H, C=O related characteristic peaks of glutathione appear at 2540, 680, 2950, and 1750 cm -1 indicating the successful co-modification of neutron-sensitive molecules and gamma-ray-sensitive molecules on the SERS substrate.

[0043] 3) Calibration of the SERS chip:

[0044] Place the SERS chip obtained in step 2) in a moderated Am-Be neutron source (300 mCi) and 60Under a Co gamma-ray source (2 μCi), irradiate at different doses (both neutron dose and gamma dose are 1 - 50 mGy), and use a Raman spectrometer to measure the SERS spectrum of the SERS chip after irradiation (each chip is measured 12 times); based on the molecular structure transformation of radiation-sensitive molecules under irradiation conditions, select characteristic peak positions for quantitative analysis, and use the relative intensities of the characteristic peak positions at 1574 and 1585 cm -1 to perform a least-squares fit on the neutron dose, and obtain the dose response function of the SERS chip to neutrons (y = 9.482x + 0.105, R 2 = 0.981). Use the relative intensities of the characteristic peak positions at 510 and 2540 cm -1 to perform a least-squares fit on the gamma dose, and obtain the dose response function of the SERS chip to gamma rays (y = 6.955x + 0.326, R 2 = 0.974), to achieve the calibration of the SERS chip;

[0045] 4) Measure the optical signal of the SERS chip: Place the calibrated SERS chip in the n-γ mixed radiation field generated by a combined source of Am-Be neutron source (300 mCi) / 60 Co gamma-ray source (2 μCi) for irradiation (the Am-Be neutron source and the Co-60 source are placed in combination to obtain the mixed field). After the irradiation is completed, take it out (the neutron dose and gamma-ray dose during irradiation are measured by a standard dosimeter, which are 20 mGy and 2 mGy respectively), and place the irradiated SERS chip on a portable Raman spectrometer to measure the SERS spectrum;

[0046] 5) Read out the radiation dosimetry information contained in the SERS chip: Extract the relative intensities of the characteristic peak positions at 1574 and 1585 cm -1 from the SERS spectrum obtained in step 4) (related to the transformation of neutron-sensitive boron-containing groups), and the relative intensities of the characteristic peak positions at 510 and 2540 cm -1 (related to the transformation of gamma-ray-sensitive redox-active groups), substitute them into the dose response functions of neutrons and gamma rays obtained in step 3), and invert the neutron dose and gamma-ray dose to achieve the self-discrimination of the n-γ mixed radiation field.

[0047] After testing, compared with the measurement results of the standard dosimeter, the relative deviations of the measurement of the neutron dose and gamma-ray dose in this example are 4.6% and 5.2% respectively, meeting the requirements of the ISO 14146:2024 standard, indicating that this method can effectively achieve the self-discrimination and accurate detection of the dose of the n-γ mixed radiation field.

[0048] Figure 2It is a structural schematic diagram of the self-discriminating detection system used in this embodiment. Under the action of the n-γ mixed radiation field 1, the SERS chip 2 generates an independent dose response to the n-γ mixed radiation field, is coupled with the portable Raman spectroscopy acquisition module 4 through the optical coupling interface 3 (BAC100B, B&W Tek) and acquires and measures the SERS spectrum. Then, through the data transmission interface 5 (CM219-15918, UGREEN), the spectral data is transmitted to the SERS spectral feature information extraction module 6 through a data line. The feature information of the SERS spectrum is extracted and analyzed. Then, through the data coupling interface 7 (CM219-15918, UGREEN), the neutron dose response function and the gamma-ray dose response function are further combined through a data line, and the neutron dose and the gamma-ray dose are discriminated and given in the radiation dose information reading module 8.

Claims

1. A method for self-discriminating detection of the dose of n-γ mixed radiation field based on SERS technology, characterized in that, The specific steps are as follows: 1) Disperse neutron-sensitive molecules and gamma-ray-sensitive molecules in a good solvent to obtain a dispersion solution; add a noble metal sol-type SERS substrate and mix, followed by stirring and reacting; after centrifugation, resuspend in ultrapure water to obtain a radiation-sensitive molecule-functionalized SERS substrate for standby; The neutron-sensitive molecule is 4-mercaptobenzeneboronic acid pinacol ester, the gamma-ray-sensitive molecule is glutathione, and the good solvent includes at least one of water or ethanol; The noble metal sol-type SERS substrate is a noble metal nanoparticle sol, and the noble metal nanoparticles include one of gold nanoparticles, silver nanoparticles, or gold / silver composite nanoparticles; In terms of molar mass ratio, neutron-sensitive molecule:noble metal nanoparticles > 100:1, gamma-ray-sensitive molecule:noble metal nanoparticles > 100:1; 2) Immerse the solid-phase substrate in Piranha solution for pretreatment, wash and dry to obtain a hydrophilic solid-phase substrate for standby; Transfer the radiation-sensitive molecule-functionalized SERS substrate array prepared in step 1 to the hydrophilic solid-phase substrate, and dry to obtain an SERS chip; Place the SERS chip prepared in step 2) under a standard neutron source and gamma-ray source, irradiate with different doses, and use a Raman spectrometer to measure the SERS spectrum of the SERS chip after irradiation; Select characteristic peak positions for quantitative analysis, fit the neutron dose and gamma dose using the relative intensities of the characteristic peak positions to obtain the dose response functions of the SERS chip for neutrons and gamma rays, and achieve the calibration of the SERS chip; after calibration, the correlation coefficients of the neutron dose response function and the gamma-ray dose response function are both greater than 0.95; Place the calibrated SERS chip in step 3) in an n-γ mixed radiation field for irradiation, take it out after irradiation is completed, and place the irradiated SERS chip on a Raman spectrometer to measure the SERS spectrum; Extract the characteristic information of the SERS spectrum obtained in step 4), and substitute it into the neutron and gamma-ray dose response functions obtained in step 3) to obtain the neutron dose and gamma-ray dose, thereby achieving self-discrimination of the n-γ mixed radiation field.

2. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 1, wherein In step 1), the concentration of the dispersion solution is 0.1 - 1 mM.

3. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 1, wherein In step 1), the concentration of the noble metal nanoparticle sol is 0.02 - 0.5 μM, and the diameter of the nanoparticles is 30 - 100 nm.

4. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 1, wherein In step 2), transferring the radiation-sensitive molecule-functionalized SERS substrate array prepared in step 1 to the hydrophilic solid-phase substrate means adding hexane to the radiation-sensitive molecule-functionalized SERS substrate, then dropping ethanol until the addition stops when a metallic luster appears at the water / hexane interface. After the hexane evaporates and a continuous bright film floats on the water surface, place the hydrophilic solid-phase substrate above the film and bring them into contact to transfer the radiation-sensitive molecule-functionalized SERS substrate array to the solid-phase substrate.

5. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 1, wherein, In step 5), the fitting method of the dose response function is the least squares method, and the function correlation coefficient is greater than 0.

95.

6. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 1, characterized in that In step 2), the solid-phase substrate includes any one of a silicon wafer, a glass slide, and a polydimethylsiloxane film.

7. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 3, wherein Step 5) The dose response function mentioned refers to that the dose response function of neutrons is y = 9.482x + 0.105, R 2 = 0.981; the dose response function of gamma rays is y = 6.955x + 0.326, R 2 = 0.

974.

8. The method for self-discriminating detection of the dose of the n-γ mixed radiation field based on the SERS technology according to claim 4, characterized in that, In step 2), the volume ratio of the radiation-sensitive molecule-functionalized SERS substrate to hexane is 4:

1.

9. An n-γ mixed radiation field dose self-discriminating detection system based on the detection method described in claims 1-8, characterized in that, The system includes a SERS chip, a portable Raman spectroscopy acquisition module, a SERS spectral feature information extraction module, and a radiation dose information reading module; the SERS chip is coupled with the portable Raman spectroscopy acquisition module through an optical fiber probe, and the portable Raman spectroscopy acquisition module, the SERS spectral feature information extraction module, and the radiation dose information reading module are connected through a data transmission interface and a data line; The portable Raman spectroscopy acquisition module is a Raman spectrometer; The SERS spectral feature information extraction module analyzes the spectral selection feature information collected by the portable Raman spectroscopy acquisition module to obtain the feature information; The radiation dose information reading module substitutes the feature information into the dose response function, converts it into a radiation dose, and reads it out.

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