Traditional Chinese medicine preparation for promoting feed conversion and preparation method thereof

Abstract

The traditional Chinese medicine preparation is a feed additive specially developed for bred animals, and is prepared by combining the traditional Chinese medicine theory with modern nutriology, performing scientific compatibility and performing gel chromatography column separation. The preparation takes rhizoma atractylodis macrocephalae and poria cocos as monarch drugs, has the effects of strengthening the spleen and stomach, and resolving dampness and promoting diuresis, and can effectively improve the digestive function of animals; and zinc gluconate and other trace elements are matched to synergistically enhance the metabolic capability of the body. The action mechanism is that the absorption and utilization rate of nutrient substances is improved by regulating gastrointestinal functions, so that the feed conversion rate is improved. Tests prove that the feed conversion rate can be increased, the breeding period can be shortened, and the feed cost can be remarkably reduced by using the preparation. The composition is suitable for common livestock and poultry, safe to use and free of drug residues.

Description

Technical Field

[0001] The present invention relates to the technical field of animal feed additives, and particularly relates to a traditional Chinese medicine preparation for promoting feed conversion, which improves feed utilization rate through the function of strengthening the spleen and regulating the stomach, and is applicable to the fields of livestock, poultry and aquaculture. Background Art

[0002] In livestock, poultry and aquaculture, feed cost accounts for 60%-70% of the total cost. Improving feed utilization rate is the key to reducing breeding cost and enhancing economic benefits. However, traditional amino acid feed additives are mostly synthetic compounds or amino acids obtained by fermentation, which can provide nutrition but have no obvious promoting effect on the absorption of nutrients. Trace element additives can supplement the trace elements required by the animal body and have no obvious promoting effect on the absorption of nutrients. In recent years, beneficial bacteria have developed rapidly. Most beneficial bacteria can produce abundant digestive enzymes, vitamins, etc., which have a significant effect on the digestive process and can degrade macromolecular substances more perfectly, but also have no obvious promoting effect on the absorption of nutrients. Therefore, it is of great practical significance to develop a green, safe and efficient traditional Chinese medicine preparation, especially to improve feed utilization rate by regulating the absorption function of animals. Summary of the Invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine preparation for promoting feed conversion, which improves the absorption function of animal intestines on nutrients through the action mechanism of strengthening the spleen and regulating the stomach, thereby improving feed utilization rate. This preparation also has the characteristics of being green, safe and residue-free.

[0004] A traditional Chinese medicine preparation for promoting feed conversion is characterized in that its raw material composition by weight is as follows: Atractylodes macrocephala 10-30 parts, Poria cocos 40-60 parts, zinc gluconate 0.02-0.5 parts.

[0005] According to the traditional Chinese medicine preparation for promoting feed conversion, the optimal weight ratio is: Atractylodes macrocephala 12 parts, Poria cocos 30 parts, zinc gluconate 0.15 parts.

[0006] According to the traditional Chinese medicine preparation for promoting feed conversion, the preparation steps are prepared according to the following process: Step 1 Remove impurities from Atractylodes macrocephala and Poria cocos, add 10 times the amount of 2% sodium carbonate solution and extract for 2 hours, then extract with 8 times the amount for 1.5 hours, filter to obtain residue ① and filtrate ①, and concentrate filtrate ① to 1 / 10 of the original volume to obtain a concentrated solution; Step 2 Adjust the concentrated solution to neutral with citric acid, add 95% ethanol for precipitation, and filter to obtain filtrate ②; Step 3 Separate filtrate ② through a Sephadex gel chromatography column, elute with purified water for 20 column volumes to obtain an eluate, concentrate the eluate by spray drying, pulverize and pass through an 80-mesh sieve to obtain an extract.

[0007] Add the extract obtained by the above method to zinc gluconate, 85% starch, and 0.1% silicon dioxide, and mix evenly to obtain the powder.

[0008] Add the extract obtained by the above method to zinc gluconate, 85% starch, and 0.5% sodium carboxymethylcellulose, mix evenly, granulate with 70% ethanol, pass through a 18-mesh sieve, dry at 60 °C, and screen with a 18-mesh sieve to obtain the granule.

[0009] Research on extraction method According to the physical properties of the active ingredients in the prescription, an extraction method using an alkaline solution and gel column separation was adopted, and the extraction temperature and gel column type were studied by orthogonal experiments. After verification in three batches of pilot tests, the process was reasonable, had good reproducibility, and was practical. The pilot test data are shown in Table 1.

[0010] Table 1 Pilot test data for extraction

[0011] Clinical verification 1. Experimental medicaments The powder and probiotic preparation of the present invention.

[0012] 2. Test pigs and grouping 2.1 Selection of sows: Select 15 sows with similar ages and production dates, divide them into groups of 5 each, namely the negative control group, the probiotic group, and the powder group of the present invention. Select 3 nursing piglets with similar weights from the nursing piglets produced by each sow as the test subjects; 2.2 Select 286 fattening piglets with an age of about 30 kg and similar ages, randomly divide them into 3 groups, namely 96 in the negative control group, 95 in the probiotic group, and 95 in the powder group of the present invention. They are raised by the same breeder under the same feeding conditions and use the same basic diet.

[0013] 3. Test methods 3.1 The negative control group of sows is fed with the basic diet, the probiotic group is fed with the basic diet supplemented with 0.1% probiotics, and the powder group of the present invention is fed with the basic diet supplemented with 0.1% of the powder of the present invention; 3.2 After grouping the fattening piglets, record the total weight of different groups respectively. 100 in the negative control group are fed with the basic diet, the probiotic group is fed with the basic diet supplemented with 0.1% probiotics, and the powder group of the present invention is fed with the basic diet supplemented with 0.1% of the powder of the present invention.

[0014] 4. Measurement items 4.1 Weigh and record the nursing piglets at 0 - 21 days old respectively, and analyze the weight differences of the data among the three groups; 4.2 When the fattening piglets grow to about 110 kg, record the total weight of the pigs and count the total feed consumption. Calculate the relationship between feed consumption and the increased weight, and calculate according to the following formula: feed conversion ratio = total feed consumption / increased weight.

[0015] 5. Test Results Table 2 Weight gain data of each group of suckling piglets Group 0-day-old 21-day-old Negative control group 1.5010±0.0368 6.2295±0.1944 Probiotic group 1.4946±0.0800 6.2678±0.3354 Powder group of the present invention 1.5013±0.0538 7.1407±0.2989* 5.1 It can be seen from Table 2 about the weight gain data of suckling piglets that: at 0 days old, there is no significant difference among the three groups; at 21 days old, there is no significant difference between the probiotic group and the negative control group; * There is a highly significant difference between the powder group of the present invention and the negative control group; * There is a highly significant difference between the powder group of the present invention and the probiotic group; Table 3 Feed conversion ratio of each group of fattening piglets Group Number (pcs) Initial total weight (kg) Final total weight (kg) Feed consumption (kg) Feed to meat ratio Negative control group 96 2983 11508 23500 2.76 Probiotic group 95 2869 12057 23500 2.56 Powder group of the present invention 95 2832 12165 22500 2.41 5.2 It can be seen from Table 3 about the feed conversion ratio data of each group of fattening piglets that the feed conversion ratio of the probiotic group is reduced by 7.25% compared with the negative control group, the feed conversion ratio of the powder group of the present invention is reduced by 5.86% compared with the probiotic group, and is reduced by 12.68% compared with the negative control group. The difference is obvious.

[0016] 6. Conclusion The above test data shows that the powder of the present invention can significantly increase the weight of suckling piglets, effectively reduce the feed conversion ratio of fattening piglets, promote animal growth, and improve the weight gain. Description of the Drawings

[0017] Figure 1 is the process flow chart of the preparation of the powder of the traditional Chinese medicine preparation for promoting feed conversion; Figure 2 is the process flow chart of the preparation of the granule of the traditional Chinese medicine preparation for promoting feed conversion. Detailed Embodiments

[0018] Example 1 Preparation of the powder of the traditional Chinese medicine preparation for promoting feed conversion Formula: Atractylodes macrocephala 12 parts, Poria cocos 30 parts, zinc gluconate 0.15 part Step 1 Remove impurities from Atractylodes macrocephala and Poria cocos, add 10 times the amount of 2% sodium carbonate solution and extract for 2 hours, then add 8 times the amount and extract for 1.5 hours, filter to obtain residue ① and filtrate ①, and concentrate filtrate ① to 1 / 10 of the original volume to obtain the concentrated solution; Step 2 Adjust the concentrated solution to neutral with citric acid, add 95% ethanol for precipitation, and filter to obtain filtrate ②; Step 3 Separate filtrate ② through a Sephadex gel chromatography column, elute with purified water for 20 column volumes to obtain the eluate, concentrate the eluate by spray drying, pulverize and pass through an 80-mesh sieve to obtain the extract.

[0019] Add the extract obtained by the above method to zinc gluconate, 85% starch, and 0.1% silica, mix evenly, and a powder agent is obtained.

[0020] Preparation of a Chinese medicinal preparation granule for promoting feed conversion in Example 2 Formula: 12 parts of Atractylodes macrocephala, 30 parts of Poria cocos, 0.15 part of zinc gluconate Step 1 Remove impurities from Atractylodes macrocephala and Poria cocos, add 10 times the amount of 2% sodium carbonate solution and extract for 2 hours, then add 8 times the amount and extract for 1.5 hours, filter to obtain residue ① and filtrate ①, and concentrate filtrate ① to 1 / 10 of the original volume to obtain a concentrated solution. Step 2 Adjust the concentrated solution to neutral with fumaric acid, add 95% ethanol for precipitation, and filter to obtain filtrate ②. Step 3 Separate filtrate ② through a Sephadex gel chromatography column, elute with purified water for 20 column volumes to obtain an eluate, concentrate the eluate by spray drying, pulverize and pass through an 80-mesh sieve to obtain an extract.

[0021] Add the extract obtained by the above method to zinc gluconate, 85% starch, and 0.5% sodium carboxymethylcellulose, mix evenly, granulate with 70% ethanol, pass through an 18-mesh sieve, dry at 60°C, and screen with an 18-mesh sieve to obtain a granule.

Claims

1. A traditional Chinese medicine preparation for promoting feed conversion, characterized in that It comprises the following components in parts by weight: Atractylodes macrocephala 10 - 30, Poria cocos 15 - 35 parts, zinc gluconate 0.4 - 2 parts; and the preparation method of this preparation is characterized by the following steps: Step 1, remove impurities from Atractylodes macrocephala and Poria cocos, add 10 times the amount of 2% sodium carbonate solution and extract for 2 hours, then extract with 8 times the amount for 1.5 hours, filter to obtain filtrate ①, concentrate filtrate ① to 1 / 10 of the original volume to obtain a concentrated solution; Step 2, adjust the concentrated solution to neutral with organic acid, add an appropriate amount of ethanol for precipitation, filter to obtain filtrate ②; Step 3, separate filtrate ② through a Sephadex gel chromatography column, elute with purified water for 20 column volumes to obtain an eluate, concentrate the eluate by spray drying, pulverize and pass through an 80-mesh sieve to obtain an extract, add excipients to the extract and mix to obtain the preparation.

2. The preparation according to claim 1, characterized in that It is made from the following raw materials in parts by weight ratio: Atractylodes macrocephala 12 parts, Poria cocos 30 parts, zinc gluconate 0.15 parts.

3. The preparation according to claim 1, characterized in that In Step 2, the organic acids include citric acid and fumaric acid.

4. The preparation according to claim 1, characterized in that When adding ethanol for precipitation to the intermediate concentrated solution in Step 2, the ethanol content should account for 70 - 80% of the total volume.

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