Tumor living body sampling device

Abstract

The invention provides a tumor living body sampling device, and relates to the field of biological sampling, the tumor living body sampling device comprises: a sampler main body, the sampler main body is a pistol-shaped structure; the inner sampling needle is coaxially and rotatably connected to the inner side of the reversing seat, the inner sampling needle is rotatably connected to the inner side of the sampling outer cylinder, the right cross sections of the sampling outer cylinder and the inner sampling needle are of arch-shaped structures, and the right end parts of the sampling outer cylinder and the inner sampling needle are of needle-shaped spine structures; hollow sampling openings are formed in arch-shaped parts on the right sides of the sampling outer cylinder and the inner sampling needle; the sampling transmission assembly is arranged in the sampler main body, and the sampling operation block drives the sampling outer cylinder and the inner sampling needle to rotate reversely at the same time through the sampling transmission assembly. The tumor tissue is rapidly and completely cut off, tearing damage is avoided, samples are isolated from the tissue, the samples are prevented from being mixed, and the problems that in the existing sampling process, the tissue is difficult to effectively cut off, tissue tearing is easily caused, and tissue samples are not pure are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of biological sampling, and particularly relates to a tumor in vivo sampling device. Background Art

[0002] In the process of tumor research, it is often necessary to conduct tumor-related experiments and research through mice. During the mouse tumor research experiment, it is necessary to perform in vivo sampling of the tumor in the mouse, and then conduct further research on the tumor tissue. Existing in vivo sampling generally uses a general-purpose puncture needle or a small clamping forceps for sampling.

[0003] For example, the present invention with the application number CN202211329381.9 proposes a tumor tissue sampling pen, which relates to the field of medical devices. The tumor tissue sampling pen includes a tissue cutting assembly, a rotating assembly, and a push rod assembly. The tissue cutting assembly includes a knife rod and a blade group, and the blade group is arranged at one end of the knife rod; the rotating assembly includes a pen body mechanism, a rotating mechanism, and a connecting rod; the rotating mechanism and the connecting rod are both arranged in the pen body mechanism, and the rotating mechanism further includes a pen cap, a guiding sleeve, and a rotating column. The pen cap is connected to the rotating column through the guiding sleeve, and one end of the rotating column away from the guiding sleeve abuts against one end of the connecting rod; the push rod assembly includes a thumb pressing part, a push rod, an elastic limiting part, a first elastic part, and a push sleeve; the elastic limiting part is arranged at one end of the push rod close to the thumb pressing part, the first elastic part and the push rod abut against each other, and one end of the push rod away from the thumb pressing part is connected to the push sleeve. By replacing different tissue cutting assemblies and push sleeves, the size of the cut tumor tissue block can be adjusted.

[0004] However, existing sampling devices can only sample body fluids or individual free cells with a general-purpose puncture needle, and cannot sample tissues completely. Although sampling with a clamping forceps can sample tissues, it is difficult to pierce the tissues, and it is difficult to effectively cut the tissues during the sampling process, which easily causes tissue tearing and affects the sample structure. At the same time, when the mouse tumor tissue sample is removed, it is easy to come into contact with tissues such as skin and muscle, resulting in impure tissue samples and affecting the sampling effect. Summary of the Invention

[0005] In view of this, the present invention provides a tumor in vivo sampling device, which synchronously rotates the sampling outer cylinder and the inner sampling needle in opposite directions, and the outer cylinder cutting edge and the inner needle cutting edge form a scissor-like shearing effect to quickly and completely cut the tumor tissue and avoid tearing damage; the hollow sampling port is combined with a closed design to isolate the sample from the tissue and prevent sample mixing. In addition, the spiky sampling end can easily pierce tough tissues, reduce the puncture resistance, and combined with the flexible adjustment function of the sampling port direction, it can accurately align tumor tissues of different positions and sizes, greatly improving the sampling accuracy and providing high-quality samples for clinical pathological detection.

[0006] The present invention provides the purpose and efficacy of a tumor in-vivo sampling device, specifically including: a sampler main body, and the sampler main body has a pistol-like structure; A sampling operation block, which is slidably connected to the upper right side of the handle of the sampler main body. The sampling operation block is elastically connected to the sampler main body through a spring. A limit stop block is arranged inside the sampler main body, and the limit stop block can limit the sliding range of the sampling operation block, so that the sampling outer cylinder and the inner sampling needle can only rotate within a 90-degree range; A commutation operation knob, which is rotatably connected to the upper left side of the handle of the sampler main body; A commutation seat, which is rotatably connected to the inside of the sampler main body; A sampling outer cylinder, which is coaxially and rotatably connected to the inside of the commutation seat; An inner sampling needle, which is coaxially and rotatably connected to the inside of the commutation seat. The inner sampling needle is rotatably connected to the inside of the sampling outer cylinder. The right cross-sections of the sampling outer cylinder and the inner sampling needle are arc-shaped structures, and the right end parts of the sampling outer cylinder and the inner sampling needle are needle-like spike structures. Hollow sampling ports are provided in the right arc-shaped parts of the sampling outer cylinder and the inner sampling needle; A commutation transmission component, which is arranged inside the sampler main body. The commutation operation knob drives the commutation seat to rotate through the commutation transmission component; A sampling transmission component, which is arranged inside the sampler main body. The sampling operation block drives the sampling outer cylinder and the inner sampling needle to rotate in the opposite direction simultaneously through the sampling transmission component.

[0007] Further, two commutation operation knobs are provided. The two commutation operation knobs are symmetrically rotated on the front and rear end faces of the sampler main body, and the two commutation operation knobs are coaxially and fixedly connected.

[0008] Further, the commutation transmission component includes: A driving pulley, which is coaxially and fixedly connected to the middle parts of the two commutation operation knobs; An intermediate driving gear, which is rotatably connected to the inside of the sampler main body; A driven pulley, which is coaxially and fixedly connected to the rear end face of the intermediate driving gear. The driven pulley and the driving pulley are connected through a synchronous transmission belt to jointly form a synchronous transmission belt drive structure.

[0009] Further, the commutation transmission component further includes: A commutation worm, which is rotatably connected to the inside of the sampler main body; An intermediate driven gear, which is coaxially and fixedly connected to the front end face of the commutation worm. The intermediate driven gear and the intermediate driving gear are meshed to jointly form a gear drive mechanism.

[0010] Further, the commutation transmission component further includes: The reversing worm gear is rotatably connected inside the sampler main body, and the reversing worm is engaged with the reversing worm gear to jointly form a worm and worm gear transmission structure.

[0011] Furthermore, the reversing transmission assembly further includes: The reversing driving gear is coaxially and fixedly connected to the right end face of the reversing worm gear; The reversing driven gear ring is coaxially and fixedly connected to the outside of the reversing seat. The reversing driving gear is engaged with the reversing driven gear ring to jointly form a gear transmission structure.

[0012] Furthermore, the sampling transmission assembly includes: The sampling driving rack is fixedly connected to the upper part of the sampling operation block; The intermediate gear is rotatably connected inside the sampler main body; The pushing block is slidably connected inside the sampler main body; The sampling driven rack is fixedly connected to the bottom of the pushing block. The upper and lower parts of the intermediate gear are respectively engaged with the sampling driven rack and the sampling driving rack to jointly form a rack and pinion transmission mechanism.

[0013] Furthermore, the sampling transmission assembly further includes: The intermediate transmission slider is slidably connected inside the reversing seat. The intermediate transmission slider is elastically connected to the reversing seat through a spring. The left side of the intermediate transmission slider is aligned with the pushing block; The intermediate transmission racks are fixedly connected to the right side of the intermediate transmission slider. The two intermediate transmission racks are symmetrically arranged about the center; There are two sampling driven gears in total. The two sampling driven gears are rotatably connected inside the reversing seat. The sampling driven gears are engaged with the intermediate transmission racks on the same side to jointly form a rack and pinion transmission mechanism.

[0014] Furthermore, the sampling transmission assembly further includes: There are two driving bevel gears in total. The two driving bevel gears are respectively coaxially and fixedly connected inside the two sampling driven gears; The outer cylinder driven bevel gear is coaxially and fixedly connected to the left end face of the sampling outer cylinder; The inner needle driven bevel gear is coaxially and fixedly connected to the left end face of the inner sampling needle. The inner needle driven bevel gear is arranged opposite to the outer cylinder driven bevel gear. The two driving bevel gears are respectively engaged with the outer cylinder driven bevel gear and the inner needle driven bevel gear on both sides to form a bevel gear transmission structure.

[0015] Furthermore, an outer cylinder cutting edge opening inward is provided at the edge of the sampling opening of the sampling outer cylinder, and an inner needle cutting edge opening inward is provided at the edge of the sampling opening of the inner sampling needle.

[0016] Advantageous effects The present invention adopts a pistol-shaped sampler body with symmetrically arranged reversing operation knobs, which conforms to the ergonomic design. The thumb and index finger can naturally control the reversing and sampling actions. The sampling outer cylinder and the inner sampling needle rotate synchronously in opposite directions, and the outer cylinder cutting edge and the inner needle cutting edge form a scissor-like shearing effect, quickly and completely cutting off the tumor tissue to avoid tearing damage. The hollow sampling opening is combined with a closed design to isolate the sample from the tissue and prevent sample mixing. In addition, the spiky sampling end can easily pierce through tough tissues, reducing the puncture resistance. Combined with the flexible adjustment function of the sampling opening direction, it can accurately align tumor tissues of different positions and sizes, greatly improving the sampling accuracy and providing high-quality samples for clinical pathological detection.

[0017] The present invention adopts a pistol-shaped sampler body, combined with two symmetrically arranged reversing operation knobs. Whether held by the left hand or the right hand, the operator can naturally control the reversing and sampling actions through the thumb and index finger, which conforms to the ergonomic principle. At the same time, the sampling operation block is elastically connected to the sampler body by a spring, and the accurate limitation of the operation range by the limit stop block controls the rotation angle of the sampling outer cylinder and the inner sampling needle within 90 degrees, avoiding misoperation, significantly reducing the operation difficulty, and improving the sampling efficiency and comfort of medical staff. The present invention utilizes the synchronous reverse rotation of the sampling outer cylinder and the inner sampling needle. During the closing process of the outer cylinder cutting edge and the inner needle cutting edge at the edge of the sampling opening, a scissor-like shearing effect is formed, which can quickly and completely cut off the tumor tissue, avoiding tissue fragmentation or structural damage caused by tearing. The hollow sampling opening design can completely accommodate the cut sample, and can well ensure the closed state of the sampling opening, creating an isolation effect between the sample and the tissue, effectively preventing the sample from mixing with other tissues during the process of being removed from the body, and ensuring the purity and reliability of the pathological detection sample. By adopting the spiky structures at the ends of the sampling outer cylinder and the inner sampling needle, the present invention can easily pierce through the tough tissue surface layer and reduce the puncture resistance. The device can conveniently adjust the opening direction of the sampling opening according to different tumor positions, sizes and tissue characteristics, facilitating alignment with the required sampling site and making the sampling more accurate. Description of the drawings

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings of the embodiments will be briefly introduced below.

[0019] The drawings in the following description only relate to some embodiments of the present invention and do not limit the present invention.

[0020] In the drawings: Figure 1 It is a schematic diagram of the overall structure of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0021] Figure 2 It is a schematic diagram of the rear structure of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0022] Figure 3 It is a schematic diagram of the internal structure of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0023] Figure 4 It is a schematic diagram of the structure of the commutation drive assembly of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0024] Figure 5 It is a schematic diagram of the drive structure of the commutation worm and the commutation worm gear of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0025] Figure 6 It is a schematic diagram of the structure of the sampling drive assembly of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0026] Figure 7 It is a schematic cross-sectional view of the sampling drive assembly of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0027] Figure 8 It is a schematic diagram of the internal structure of the commutation seat of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0028] Figure 9 It is a schematic diagram of the structure of the sampling outer cylinder of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0029] Figure 10 It is a schematic diagram of the structure of the inner sampling needle of the tumor in-vivo sampling device according to an embodiment of the present invention.

[0030] List of reference numerals 1. Sampler main body; 2. Sampling operation block; 201. Sampling drive rack; 3. Intermediate gear; 4. Pushing block; 401. Sampling driven rack; 5. Intermediate drive slider; 501. Intermediate drive rack; 6. Sampling driven gear; 7. Driving bevel gear; 8. Sampling outer cylinder; 801. Outer cylinder driven bevel gear; 802. Outer cylinder cutting edge; 9. Inner sampling needle; 901. Inner needle driven bevel gear; 902. Inner needle cutting edge; 10. Commutation operation knob; 1001. Driving pulley; 11. Intermediate driving gear; 1101. Driven pulley; 12. Commutation worm; 1201. Intermediate driven gear; 13. Commutation worm gear; 1301. Commutation driving gear; 14. Commutation seat; 1401. Commutation driven gear ring. Detailed implementation manners

[0031] Embodiment 1: Please refer toFigures 1 to 5 As shown in: The present invention provides a tumor in-vivo sampling device, including a sampler main body. The sampler main body 1 has a pistol-like structure, which is convenient for holding and operating and has better ergonomics; A sampling operation block 2, the sampling operation block 2 is slidably connected to the upper right side of the handle of the sampler main body 1. The sampling operation block 2 is elastically connected to the sampler main body 1 through a spring. A limit stop block is arranged inside the sampler main body 1, and the limit stop block can limit the sliding range of the sampling operation block 2, so that the sampling outer cylinder 8 and the inner sampling needle 9 can only rotate within a 90-degree range; A commutation operation knob 10, the commutation operation knob 10 is rotatably connected to the upper left side of the handle of the sampler main body 1; A commutation seat 14, the commutation seat 14 is rotatably connected inside the sampler main body 1; A sampling outer cylinder 8, the sampling outer cylinder 8 is coaxially rotatably connected to the inside of the commutation seat 14; An inner sampling needle 9, the inner sampling needle 9 is coaxially rotatably connected to the inside of the commutation seat 14. The inner sampling needle 9 is rotatably connected to the inside of the sampling outer cylinder 8. The right cross-sections of the sampling outer cylinder 8 and the inner sampling needle 9 are arcuate structures. The right ends of the sampling outer cylinder 8 and the inner sampling needle 9 are needle-like spike structures. Hollow sampling ports are provided in the right arcuate parts of the sampling outer cylinder 8 and the inner sampling needle 9, and tumor tissues are sampled through the sampling ports; A commutation transmission assembly, the commutation transmission assembly is arranged inside the sampler main body 1, and the commutation operation knob 10 drives the commutation seat 14 to rotate through the commutation transmission assembly.

[0032] Among them, two commutation operation knobs 10 are provided. The two commutation operation knobs 10 are symmetrically rotated on the front and rear end faces of the sampler main body 1. The two commutation operation knobs 10 are coaxially fixedly connected. During use, hold the handle of the sampler main body 1 by hand, operate the sampling operation block 2 with the index finger, and operate the commutation operation knob 10 with the thumb. By setting two symmetrical commutation operation knobs 10, whether holding with the left hand or the right hand, the thumb can conveniently operate the commutation operation knob 10, which is convenient to use and more in line with ergonomics.

[0033] Among them, the commutation transmission assembly includes: A driving pulley 1001, the driving pulley 1001 is coaxially fixedly connected to the middle parts of the two commutation operation knobs 10; An intermediate driving gear 11, the intermediate driving gear 11 is rotatably connected inside the sampler main body 1; The driven pulley 1101 is coaxially and fixedly connected to the rear end face of the intermediate driving gear 11. The driven pulley 1101 and the driving pulley 1001 are connected by a synchronous drive belt to jointly form a synchronous drive belt transmission structure. During use, when the reversing operation knob 10 is toggled, the reversing operation knob 10 drives the intermediate driving gear 11 to rotate through the synchronous drive belt transmission structure jointly formed by the driven pulley 1101 and the driving pulley 1001.

[0034] Among them, the reversing transmission assembly further includes: The reversing worm 12 is rotatably connected inside the sampler main body 1; The intermediate driven gear 1201 is coaxially and fixedly connected to the front end face of the reversing worm 12. The intermediate driven gear 1201 and the intermediate driving gear 11 are meshed to jointly form a gear transmission mechanism. During use, when the intermediate driving gear 11 rotates, the intermediate driving gear 11 drives the reversing worm 12 to rotate through the gear transmission mechanism jointly formed by the intermediate driven gear 1201 and the intermediate driving gear 11.

[0035] Among them, the reversing transmission assembly further includes: The reversing worm gear 13 is rotatably connected inside the sampler main body 1. The reversing worm 12 and the reversing worm gear 13 are meshed to jointly form a worm and worm gear transmission structure. During use, when the reversing worm 12 rotates, the reversing worm 12 drives the reversing worm gear 13 to rotate through the worm and worm gear transmission structure formed by the reversing worm 12 and the reversing worm gear 13. By utilizing the self-locking characteristic of the worm and worm gear transmission mechanism, the rotation of the reversing seat 14 during the sampling process is effectively avoided, ensuring the accuracy of sampling.

[0036] Among them, the reversing transmission assembly further includes: The reversing driving gear 1301 is coaxially and fixedly connected to the right end face of the reversing worm gear 13; The reversing driven gear ring 1401 is coaxially and fixedly connected to the outside of the reversing seat 14. The reversing driving gear 1301 and the reversing driven gear ring 1401 are meshed to jointly form a gear transmission structure. During use, when the reversing worm gear 13 rotates, the reversing worm gear 13 drives the reversing seat 14 to rotate through the gear transmission structure formed by the reversing driving gear 1301 and the reversing driven gear ring 1401.

[0037] Embodiment 2: Please refer to Figures 6 to 10 as shown: The present invention provides a tumor in vivo sampling device, including a sampling transmission assembly. The sampling transmission assembly is arranged inside the sampler main body 1. The sampling operation block 2 drives the sampling outer cylinder 8 and the inner sampling needle 9 to rotate in opposite directions simultaneously through the sampling transmission assembly.

[0038] Among them, the sampling transmission component includes: A sampling driving rack 201, which is fixedly connected to the upper part of the sampling operation block 2; An intermediate gear 3, which is rotatably connected inside the sampler body 1; A pushing block 4, which is slidably connected inside the sampler body 1; A sampling driven rack 401, which is fixedly connected to the bottom of the pushing block 4. The upper and lower parts of the intermediate gear 3 are respectively meshed with the sampling driven rack 401 and the sampling driving rack 201 to jointly form a gear-rack transmission mechanism. During use, when the sampling operation block 2 is pressed to the left, the sampling operation block 2 drives the intermediate gear 3 to rotate through the gear-rack transmission mechanism, and the intermediate gear 3 drives the pushing block 4 to slide left and right through the gear-rack transmission mechanism.

[0039] Among them, the sampling transmission component further includes: An intermediate transmission slider 5, which is slidably connected inside the reversing seat 14. The intermediate transmission slider 5 is elastically connected to the reversing seat 14 through a spring, and the left side of the intermediate transmission slider 5 is aligned with the pushing block 4; An intermediate transmission rack 501. Two intermediate transmission racks 501 are fixedly connected to the right side of the intermediate transmission slider 5, and the intermediate transmission racks 501 are symmetrically arranged about the center; Two sampling driven gears 6 are provided. The two sampling driven gears 6 are rotatably connected inside the reversing seat 14. The sampling driven gears 6 are meshed with the intermediate transmission racks 501 on the same side to jointly form a gear-rack transmission mechanism. During use, when the pushing block 4 slides to the right, the pushing block 4 pushes the intermediate transmission slider 5 to slide to the right, and the intermediate transmission slider 5 drives the two sampling driven gears 6 to rotate synchronously and in opposite directions through the gear-rack transmission mechanism.

[0040] Among them, the sampling transmission component further includes: Two driving bevel gears 7 are provided. The two driving bevel gears 7 are respectively coaxially and fixedly connected inside the two sampling driven gears 6; An outer cylinder driven bevel gear 801, which is coaxially and fixedly connected to the left end face of the sampling outer cylinder 8; The inner needle driven bevel gear 901 is coaxially and fixedly connected to the left end face of the inner sampling needle 9. The inner needle driven bevel gear 901 is disposed opposite to the outer cylinder driven bevel gear 801. The two driving bevel gears 7 are respectively engaged with the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 on both sides to form a bevel gear transmission structure. During use, when the sampling driven gear 6 rotates, the sampling driven gear 6 drives the driving bevel gear 7 to rotate. The driving bevel gear 7 drives the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 to slide synchronously and reversely through the bevel gear transmission mechanism, realizing the synchronous reverse rotation of the sampling outer cylinder 8 and the inner sampling needle 9.

[0041] Wherein, an outer cylinder cutting edge 802 opening inward is provided at the edge of the sampling port of the sampling outer cylinder 8, and an inner needle cutting edge 902 opening inward is provided at the edge of the sampling port of the inner sampling needle 9. In the initial state, the sampling ports of the sampling outer cylinder 8 and the inner sampling needle 9 overlap. When the sampling outer cylinder 8 and the inner sampling needle 9 rotate synchronously and reversely, the sampling ports are closed, and the tumor tissue is sheared by the outer cylinder cutting edge 802 and the inner needle cutting edge 902 to realize the sampling action. At the same time, a closed cavity structure is jointly formed inside the sampling ports of the sampling outer cylinder 8 and the inner sampling needle 9.

[0042] Specific usage method and function of this embodiment: When the present invention is in use, hold the handle of the sampler main body 1, operate the sampling operation block 2 with the index finger, and operate the reversing operation knob 10 with the thumb. When sampling, pierce the sampling tissue through the spikes at the right end of the sampling outer cylinder 8 and the inner sampling needle 9. When it is necessary to adjust the orientation of the sampling port, rotate the reversing operation knob 10 with the thumb. The reversing operation knob 10 drives the intermediate driving gear 11 to rotate through the synchronous belt transmission structure jointly composed of the driven pulley 1101 and the driving pulley 1001. The intermediate driving gear 11 drives the reversing worm 12 to rotate through the gear transmission mechanism jointly composed of the intermediate driven gear 1201 and the intermediate driving gear 11. The reversing worm 12 drives the reversing worm wheel 13 to rotate through the worm and worm wheel transmission structure composed of the reversing worm 12 and the reversing worm wheel 13. The reversing worm wheel 13 drives the reversing seat 14 to rotate through the gear transmission structure composed of the reversing driving gear 1301 and the reversing driven gear ring 1401. The reversing seat 14 drives the sampling outer cylinder 8 and the inner sampling needle 9 to rotate simultaneously, changing the opening direction of the sampling port. When selecting the tissue to be sampled, press the sampling operation block 2. The sampling operation block 2 drives the intermediate gear 3 to rotate through the gear rack transmission mechanism. The intermediate gear 3 drives the pushing block 4 to slide to the right through the gear rack transmission mechanism. The pushing block 4 pushes the intermediate transmission slider 5 to slide to the right. The intermediate transmission slider 5 drives the two sampling driven gears 6 to rotate synchronously and reversely through the gear rack transmission mechanism. The sampling driven gear 6 drives the driving bevel gear 7 to rotate. The driving bevel gear 7 drives the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 to slide synchronously and reversely through the bevel gear transmission mechanism, realizing the synchronous reverse rotation of the sampling outer cylinder 8 and the inner sampling needle 9. The sampling port is closed, and the tumor tissue is sheared by the outer cylinder cutting edge 802 and the inner needle cutting edge 902 to complete the sampling action. The cut sample is stored in the sampling port. When the sampling operation block 2 is released, under the action of the spring, the sampling outer cylinder 8 and the inner sampling needle 9 return to their original positions, and the sampling port is opened, and the sample in the sampling port can be extracted.

Claims

1. A tumor in vivo sampling device, characterized in that, Comprising: A sampler body, the sampler body (1) being in a pistol-like structure; A sampling operation block (2), the sampling operation block (2) being slidably connected to the upper right side of the handle of the sampler body (1), the sampling operation block (2) being elastically connected to the sampler body (1) by a spring, and a limiting stop block being provided inside the sampler body (1); A commutation operation knob (10), the commutation operation knob (10) being rotatably connected to the upper left side of the handle of the sampler body (1); A commutation seat (14), the commutation seat (14) being rotatably connected inside the sampler body (1); An outer sampling cylinder (8), the outer sampling cylinder (8) being coaxially rotatably connected inside the commutation seat (14); An inner sampling needle (9), the inner sampling needle (9) being coaxially rotatably connected inside the commutation seat (14), the inner sampling needle (9) being rotatably connected inside the outer sampling cylinder (8), the right cross-sections of the outer sampling cylinder (8) and the inner sampling needle (9) being in an arcuate structure, the right end parts of the outer sampling cylinder (8) and the inner sampling needle (9) being in a needle-like spike structure, and hollow sampling ports being provided in the right arcuate parts of the outer sampling cylinder (8) and the inner sampling needle (9); A commutation transmission assembly, the commutation transmission assembly being provided inside the sampler body (1), and the commutation operation knob (10) driving the commutation seat (14) to rotate through the commutation transmission assembly; A sampling transmission assembly, the sampling transmission assembly being provided inside the sampler body (1), and the sampling operation block (2) driving the outer sampling cylinder (8) and the inner sampling needle (9) to rotate in the opposite direction simultaneously through the sampling transmission assembly.

2. The tumor in vivo sampling device according to claim 1, wherein: There are two commutation operation knobs (10) in total, and the two commutation operation knobs (10) are symmetrically rotatably arranged on the front and rear end faces of the sampler body (1), and the two commutation operation knobs (10) are coaxially fixedly connected.

3. The tumor in vivo sampling device according to claim 1, characterized in that: The commutation transmission assembly includes: A driving pulley (1001), the driving pulley (1001) being coaxially fixedly connected to the middle parts of the two commutation operation knobs (10); An intermediate driving gear (11), the intermediate driving gear (11) being rotatably connected inside the sampler body (1); A driven pulley (1101), the driven pulley (1101) being coaxially fixedly connected to the rear end face of the intermediate driving gear (11), and the driven pulley (1101) and the driving pulley (1001) being connected by a synchronous transmission belt to jointly form a synchronous transmission belt transmission structure.

4. The tumor in vivo sampling device according to claim 3, characterized in that: The commutation transmission assembly further includes: A commutation worm (12), the commutation worm (12) being rotatably connected inside the sampler body (1); An intermediate driven gear (1201), the intermediate driven gear (1201) being coaxially fixedly connected to the front end face of the commutation worm (12), and the intermediate driven gear (1201) and the intermediate driving gear (11) being engaged to jointly form a gear transmission mechanism.

5. The tumor in vivo sampling device according to claim 4, characterized in that: The commutation transmission assembly further includes: A commutation worm gear (13), the commutation worm gear (13) being rotatably connected inside the sampler body (1), and the commutation worm (12) and the commutation worm gear (13) being engaged to jointly form a worm and worm gear transmission structure.

6. The tumor in vivo sampling device according to claim 5, characterized in that: The commutation transmission assembly further includes: The reversing drive gear (1301) is coaxially and fixedly connected to the right end face of the reversing worm gear (13). The reversing driven gear ring (1401) is coaxially and fixedly connected to the outside of the reversing seat (14). The reversing drive gear (1301) and the reversing driven gear ring (1401) are meshed to jointly form a gear transmission structure.

7. The tumor in vivo sampling device according to claim 1, wherein: The sampling transmission assembly includes: The sampling drive rack (201) is fixedly connected to the upper part of the sampling operation block (2). The intermediate gear (3) is rotatably connected inside the sampler main body (1). The pushing block (4) is slidably connected inside the sampler main body (1). The sampling driven rack (401) is fixedly connected to the bottom of the pushing block (4). The upper and lower parts of the intermediate gear (3) are respectively meshed with the sampling driven rack (401) and the sampling drive rack (201) to jointly form a gear-rack transmission mechanism.

8. The tumor in vivo sampling device according to claim 7, characterized in that: The sampling transmission assembly further includes: The intermediate transmission slider (5) is slidably connected inside the reversing seat (14). The intermediate transmission slider (5) and the reversing seat (14) are elastically connected by a spring. The left side of the intermediate transmission slider (5) is aligned with the pushing block (4). The intermediate transmission rack (501): Two intermediate transmission racks (501) are fixedly connected to the right side of the intermediate transmission slider (5). The intermediate transmission racks (501) are symmetrically arranged about the center. Two sampling driven gears (6) are provided. The two sampling driven gears (6) are rotatably connected inside the reversing seat (14). The sampling driven gears (6) and the intermediate transmission racks (501) on the same side are meshed to jointly form a gear-rack transmission mechanism.

9. The tumor in vivo sampling device according to claim 8, wherein: The sampling transmission assembly further includes: Two driving bevel gears (7) are provided. The two driving bevel gears (7) are respectively coaxially and fixedly connected inside the two sampling driven gears (6). The outer cylinder driven bevel gear (801) is coaxially and fixedly connected to the left end face of the sampling outer cylinder (8). The inner needle driven bevel gear (901) is coaxially and fixedly connected to the left end face of the inner sampling needle (9). The inner needle driven bevel gear (901) and the outer cylinder driven bevel gear (801) are arranged oppositely. The two driving bevel gears (7) are respectively meshed with the outer cylinder driven bevel gear (801) and the inner needle driven bevel gear (901) on both sides to form a bevel gear transmission structure.

10. The tumor in vivo sampling device according to claim 9, wherein: An outer cylinder cutting edge (802) opening inward is provided at the edge of the sampling port of the sampling outer cylinder (8), and an inner needle cutting edge (902) opening inward is provided at the edge of the sampling port of the inner sampling needle (9).

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