Penetration promoting composition containing PDRN and glabridin and application of permeation promoting composition in functional skin care product

Abstract

The invention provides a permeation promoting composition containing PDRN and glabridin and application of the permeation promoting composition in functional skin care products. The composition comprises the following components in percentage by mass: 0.01%-5% of glabridin, 0.1%-10% of glycyrrhizic acid ester stearate, 0.01%-2% of DNA sodium, 0.1%-10% of poloxamer, 0.05%-8% of carbomer, 0.5%-5% of sodium hyaluronate and the balance of one or more of water or solvents such as butanediol, glycerol, 1.3-propylene glycol and the like. In the composition, poloxamer is self-assembled in a system to form micelles, glabridin is wrapped in an inner core, and a PEO chain segment on an outer layer is combined with hyaluronic acid through a hydrogen bond to form a molecular-level wrapping structure, so that the problem of instability of glabridin is effectively solved, meanwhile, the problem of agglomeration of glabridin can be effectively avoided, and the whitening effect of glabridin is effectively promoted. Meanwhile, the glabridin, the glycyrrhizic acid ester stearate, the DNA sodium, the poloxamer, the carbomer and the hyaluronic acid are synergistically matched, so that the composition has good whitening, anti-wrinkle and penetration promoting effects.

Description

Technical Field

[0001] The present invention relates to the technical field of efficacy skin care products, and particularly relates to a PDRN and glabridin-containing penetration enhancing composition and its application in efficacy skin care products. Background Art

[0002] With the improvement of people's living standards, the requirements for the efficacy of skin care products are getting higher and higher, and whitening and anti-wrinkle have become the focus of attention of many consumers. Glabridin is a natural ingredient extracted from licorice, which has excellent whitening efficacy and can effectively inhibit the activity of tyrosinase and reduce the production of melanin. However, glabridin has problems such as poor stability and easy aggregation, which seriously affect its application effect in skin care products and limit the full play of its whitening efficacy.

[0003] At the same time, in order to make the active ingredients in skin care products better absorbed by the skin, the penetration enhancing technology is crucial. Traditional penetration enhancing methods have certain limitations, either with poor effects or may cause irritation to the skin. Therefore, developing a composition that can effectively solve the stability and aggregation problems of glabridin and at the same time has good penetration enhancing efficacy is of great significance for improving the quality of efficacy skin care products. Summary of the Invention

[0004] The purpose of the present invention is to provide a PDRN (sodium DNA) and glabridin-containing penetration enhancing composition, which can effectively solve the stability and aggregation problems of glabridin through the synergistic cooperation of each component, and at the same time enhance the whitening, anti-wrinkle and penetration enhancing efficacy of the composition. Applying it to efficacy skin care products can provide consumers with higher-quality skin care products.

[0005] A PDRN and glabridin-containing penetration enhancing composition comprises the following components in mass percentage: glabridin 0.01% - 5%, glycyrrhetinic acid stearate 0.1% - 10%, sodium DNA 0.01% - 2%, poloxamer 0.1% - 10%, carbomer 0.05% - 8%, sodium hyaluronate 0.5% - 5% and the balance of solvent.

[0006] Optionally, it comprises the following components in mass percentage: glabridin 0.1% - 3%, glycyrrhetinic acid stearate 0.5% - 5%, sodium DNA 0.05% - 1%, poloxamer 0.5% - 5%, carbomer 0.1% - 3%, sodium hyaluronate 1% - 3% and the balance of solvent.

[0007] Optionally, it comprises the following components in mass percentage: glabridin 1% - 2%, glycyrrhetinic acid stearate 1% - 2%, sodium DNA 0.06% - 0.08%, poloxamer 1% - 3%, carbomer 0.8% - 1.5%, sodium hyaluronate 1.5% - 2.5% and the balance of solvent.

[0008] Optionally, each component includes the following mass percentages: glabridin 1.5%, glycyrrhetinic acid stearate 1.5%, sodium DNA 0.07%, poloxamer 1.5%, carbomer 1.1%, sodium hyaluronate 1.8%, and the balance being solvent.

[0009] Optionally, the pH value of the PDRN and glabridin penetration - promoting composition is 5.5 - 7.2.

[0010] Optionally, the solvent includes one or more of water, butylene glycol, glycerol, and 1,3 - propanediol.

[0011] Optionally, the solvent is a mixture of water and butylene glycol, wherein the mass ratio of water to butylene glycol is (2 - 5):1.

[0012] A preparation method of the PDRN and glabridin penetration - promoting composition as described above includes the following steps: Mix carbomer with the solvent at a first stirring speed of 30 - 50 rpm for 1 - 2 h to obtain a swollen product; Sequentially add glabridin, glycyrrhetinic acid stearate, sodium DNA, poloxamer, and sodium hyaluronate to the swollen product. After adding each component, mix the product at a second stirring speed of 60 - 70 rpm for 10 - 15 min to obtain a pre - finished product; Homogenize the pre - finished product 2 - 3 times at a pressure of 10 - 20 MPa, with the homogenization time being 2 - 3 min each time, and then adjust the pH value to 5.5 - 7.2.

[0013] An application of the PDRN and glabridin penetration - promoting composition as described above in efficacy skin care products.

[0014] An efficacy skin care product includes the PDRN and glabridin penetration - promoting composition as described above.

[0015] Beneficial effects (1) Solve the problems of glabridin stability and aggregation: Poloxamer self - assembles into micelles in the system. The core encapsulates glabridin, and the outer PEO chain segments bind to hyaluronic acid through hydrogen bonds to form a molecular - level encapsulation structure, effectively solving the problem of glabridin instability. At the same time, it can avoid the aggregation of glabridin, enabling glabridin to exist in a uniformly dispersed state in the composition and fully exert its whitening effect.

[0016] (2)Synergistically enhance the whitening and anti-wrinkle effects: Glabridin inhibits the activity of tyrosinase to reduce melanin production. Glycyrrhetinic acid stearate has anti-inflammatory and antioxidant effects, which can reduce pigmentation caused by skin inflammation. DNA sodium can promote the repair and regeneration of skin cells, enhance the elasticity and luster of the skin, thereby achieving a synergistic effect of whitening and anti-wrinkle.

[0017] (3)Good penetration-promoting effect: The structure formed by the combination of poloxamer and hyaluronic acid helps to change the skin permeability, making the active ingredients in the composition easier to penetrate into the deep layer of the skin. Carbomer can regulate the viscosity and rheology of the composition, making it better adhere to the skin surface and further promoting the penetration of active ingredients. Detailed implementation mode

[0018] An embodiment of the present invention provides a penetration-promoting composition containing PDRN and glabridin, which includes the following components in mass percentage: glabridin 0.01%-5%, glycyrrhetinic acid stearate 0.1%-10%, DNA sodium 0.01%-2%, poloxamer 0.1%-10%, carbomer 0.05%-8%, sodium hyaluronate 0.5%-5% and the balance of solvent. In this composition, poloxamer self-assembles into micelles in the system, with glabridin encapsulated in the core, and the outer PEO chain segment combines with hyaluronic acid through hydrogen bonds to form a molecular-level encapsulation structure, effectively solving the problem of glabridin instability, and at the same time effectively avoiding the aggregation problem of glabridin, and effectively promoting the whitening effect of glabridin. At the same time, the synergistic cooperation of glabridin, glycyrrhetinic acid stearate, DNA sodium, poloxamer, carbomer and hyaluronic acid can endow the composition with good whitening, anti-wrinkle and penetration-promoting effects.

[0019] It can be understood that DNA sodium is PDRN.

[0020] It can be understood that in the penetration-promoting composition containing PDRN and glabridin, the total mass percentage of glabridin, glycyrrhetinic acid stearate, DNA sodium, poloxamer, carbomer, sodium hyaluronate and solvent is 100%.

[0021] In some embodiments, the penetration-promoting composition containing PDRN and glabridin includes the following components in mass percentage: glabridin 0.1%-3%, glycyrrhetinic acid stearate 0.5%-5%, DNA sodium 0.05%-1%, poloxamer 0.5%-5%, carbomer 0.1%-3%, sodium hyaluronate 1%-3% and the balance of solvent.

[0022] In these embodiments, the content of each component in the composition is further optimized, further improving the whitening, anti-wrinkle and penetration-promoting effects of the composition.

[0023] For example, further optimize the content of glabridin, while ensuring the whitening effect, reduce the possible cost increase and stability problems caused by too high content.

[0024] Further optimize the content of glycyrrhetinic acid stearate to enhance the anti-inflammatory and antioxidant effects of the composition, better cooperate with glabridin to achieve the whitening effect, and reduce skin inflammation.

[0025] Further optimize the appropriate content of sodium DNA to promote the repair and regeneration of skin cells more significantly, and enhance skin elasticity and luster.

[0026] Further optimize the content of poloxamer to make it form micelles to encapsulate glabridin and combine with hyaluronic acid better, more effectively solve the stability and aggregation problems of glabridin, and promote penetration.

[0027] Further optimize the content of carbomer to better regulate the viscosity and rheology of the composition, make its adhesion effect on the skin surface better, and promote the penetration of active ingredients.

[0028] Further optimize the content of sodium hyaluronate to enhance its binding effect with poloxamer and improve the moisturizing and penetration ability of the skin.

[0029] In some embodiments, the PDRN and glabridin-containing penetration-promoting composition comprises the following components in mass percentages: glabridin 1%-2%, glycyrrhetinic acid stearate 1%-2%, sodium DNA 0.06%-0.08%, poloxamer 1%-3%, carbomer 0.8%-1.5%, sodium hyaluronate 1.5%-2.5%, and the balance being solvent.

[0030] Optionally, the PDRN and glabridin-containing penetration-promoting composition comprises the following components in mass percentages: glabridin 1.5%, glycyrrhetinic acid stearate 1.5%, sodium DNA 0.07%, poloxamer 1.5%, carbomer 1.1%, sodium hyaluronate 1.8%, and the balance being solvent.

[0031] In some embodiments, the pH value of the PDRN and glabridin-containing penetration-promoting composition is 5.5-7.2. Controlling the pH value of the composition within a suitable range can ensure the stability and activity of each component, and at the same time make the composition more suitable for the physiological environment of the skin and reduce the irritation to the skin. Optionally, the pH value of the composition can be 5.5, 5.8, 6, 6.2, 6.5, 7, 7.2, etc.

[0032] In some embodiments, the solvent comprises one or more of water, butylene glycol, glycerol, and 1,3-propanediol.

[0033] Further, the solvent is a mixture of water and butanediol, wherein the mass ratio of water to butanediol is (2 - 5):1. The combined solvent of water and butanediol enables each component to dissolve and disperse better in the system, ensuring the stability and uniformity of the composition.

[0034] Another embodiment of the present invention provides a method for preparing a composition for promoting the penetration of PDRN and glabridin, comprising the following steps: Mix carbomer with the solvent at a first stirring speed of 30 - 50 rpm for 1 - 2 h to obtain a swollen product; Add glabridin, glycyrrhetinic acid stearate, sodium DNA, poloxamer, and sodium hyaluronate to the swollen product in sequence. After adding each component, mix the product at a second stirring speed of 60 - 70 rpm for 10 - 15 min to obtain a pre - product; Homogenize the pre - product 2 - 3 times at a pressure of 10 - 20 MPa, with the homogenization time of each time being 2 - 3 min, and then adjust the pH value to 5.5 - 7.2.

[0035] Optionally, citric acid and sodium hydroxide can be used to adjust the pH value.

[0036] The above - mentioned preparation method is simple and easy to implement, facilitating the implementation, and can effectively promote the development of efficacy compositions and efficacy skin care products.

[0037] It can be understood that when the solvent includes multiple components, first mix each component to obtain the solvent, and then mix carbomer with the solvent. For example, when the solvent is a mixture of water and butanediol, first mix water and butanediol to obtain the solvent, and then mix carbomer with water.

[0038] Another embodiment of the present invention provides an application of the above - mentioned composition for promoting the penetration of PDRN and glabridin in efficacy skin care products. Applying the composition with excellent performance to efficacy skin care products can provide skin care products with good whitening, anti - wrinkle, and penetration - promoting effects for consumers.

[0039] Another embodiment of the present invention provides an efficacy skin care product comprising the above - mentioned composition for promoting the penetration of PDRN and glabridin.

[0040] Optionally, the mass percentage of the composition for promoting the penetration of PDRN and glabridin in the skin care product is 2% - 5%.

[0041] Optionally, the skin care product can be a cream, lotion, essence, etc.

[0042] Example 1 In this example, the components and their mass percentages in the PDRN and glabridin penetration-enhancing composition are as follows: glabridin 1.5%, glycyrrhetinic acid stearate 1.5%, sodium DNA 0.07%, poloxamer 1.5%, carbomer 1.1%, sodium hyaluronate 1.8%, and the balance is solvent. The sum of the mass percentages of the components is 100%. The solvent is a mixture of water and butylene glycol, and the mass ratio of water to butylene glycol is 3:1.

[0043] The preparation method of the PDRN and glabridin penetration-enhancing composition is as follows: S1: Mix carbomer with the solvent at a first stirring speed of 40 rpm for 1.5 h to obtain a swollen product.

[0044] S2: Sequentially add glabridin, glycyrrhetinic acid stearate, sodium DNA, poloxamer, and sodium hyaluronate to the swollen product. After adding each component, mix the product at a second stirring speed of 65 rpm for 10 min to obtain a pre-finished product.

[0045] S3: Homogenize the pre-finished product 3 times at a pressure of 15 MPa, with each homogenization time being 2 min, and then adjust the pH value to 7.

[0046] Examples 2-7, Comparative Examples 1-5 Compared with Example 1, Example 2 is different in that the components and mass percentages of the composition are different. Specifically, they are shown in Table 1.

[0047] Test Example Prepare the compositions of the examples and comparative examples into creams. Among them, the mass percentage of the composition in the cream is 2%.

[0048] Test subjects: 120 volunteers aged 25-45 with moderate chloasma or freckles and other pigmentation problems on the face, randomly divided into 12 groups, with 10 people in each group, 5 men and 5 women.

[0049] Apply the creams of the examples and comparative examples to the 12 groups of volunteers respectively. Use them once in the morning and once in the evening every day for 4 consecutive weeks.

[0050] (1) Use a skin elasticity tester and a wrinkle analyzer to measure the skin elasticity value and wrinkle depth of the volunteers' facial skin before and after 4 weeks of use respectively. After use, the average increase rate of skin elasticity value and the average reduction rate of wrinkle depth are shown in Table 1.

[0051] (2)Before using the cream, use a skin colorimeter to measure the initial skin color of the test areas on the faces of all volunteers (select the cheek area where freckles are more concentrated, with an area of about 4 cm²). Measure the skin color at the same position again after 4 weeks of using the cream, and calculate the increase in the L value (brightness value, the higher the value, the brighter and whiter the skin). Take the average value of each group as the test value. The test results are shown in Table 1.

[0052] Table 1

[0053] As can be seen from Table 1, the composition in the examples has a better whitening and anti-wrinkle effect compared with the comparative examples.

[0054] The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

[0055] For those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation manner and application scope. In summary, the content of this specification should not be construed as a limitation to the present invention.

Claims

1. A penetration-enhancing composition containing PDRN and glabridin, characterized in that, Comprising the following components in mass percentages: glabridin 0.01% - 5%, glycyrrhetinic acid stearate 0.1% - 10%, sodium DNA 0.01% - 2%, poloxamer 0.1% - 10%, carbomer 0.05% - 8%, sodium hyaluronate 0.5% - 5% and the balance being solvent.

2. The PDRN- and glabridin-containing penetration enhancing composition according to claim 1, wherein Comprising the following components in mass percentages: glabridin 0.1% - 3%, glycyrrhetinic acid stearate 0.5% - 5%, sodium DNA 0.05% - 1%, poloxamer 0.5% - 5%, carbomer 0.1% - 3%, sodium hyaluronate 1% - 3% and the balance being solvent.

3. The PDRN- and glabridin-containing penetration enhancing composition according to claim 1, wherein Comprising the following components in mass percentages: glabridin 1% - 2%, glycyrrhetinic acid stearate 1% - 2%, sodium DNA 0.06% - 0.08%, poloxamer 1% - 3%, carbomer 0.8% - 1.5%, sodium hyaluronate 1.5% - 2.5% and the balance being solvent.

4. The PDRN- and glabridin-containing penetration enhancing composition according to claim 1, wherein Comprising the following components in mass percentages: glabridin 1.5%, glycyrrhetinic acid stearate 1.5%, sodium DNA 0.07%, poloxamer 1.5%, carbomer 1.1%, sodium hyaluronate 1.8% and the balance being solvent.

5. The PDRN- and glabridin-containing penetration enhancing composition according to any one of claims 1-4, wherein The pH value of the PDRN and glabridin-containing penetration-enhancing composition is 5.5 - 7.

2.

6. The PDRN- and glabridin-containing penetration enhancing composition according to any one of claims 1 to 4, characterized in that, The solvent includes one or more of water, butylene glycol, glycerol, 1,3-propanediol.

7. The PDRN- and glabridin-containing penetration-enhancing composition according to claim 6, wherein The solvent is a mixture of water and butylene glycol, wherein the mass ratio of water to butylene glycol is (2 - 5):

1.

8. A preparation method of the PDRN- and glabridin-containing penetration enhancing composition according to any one of claims 1-7, characterized in that, Comprising the following steps: Mix carbomer with the solvent at a first stirring speed of 30 - 50 rpm for 1 - 2 h to obtain a swollen product; Sequentially add glabridin, glycyrrhetinic acid stearate, sodium DNA, poloxamer and sodium hyaluronate to the swollen product. After adding each component, mix the product at a second stirring speed of 60 - 70 rpm for 10 - 15 min to obtain a pre-finished product; Homogenize the pre-finished product 2 - 3 times at a pressure of 10 - 20 MPa, with the homogenization time for each time being 2 - 3 min, and then adjust the pH value to 5.5 - 7.

2.

9. Use of the PDRN and glabridin-containing penetration-enhancing composition according to any one of claims 1 - 7 in efficacy skin care products.

10. A skin care product with functions, characterized in that, Comprising the PDRN and glabridin-containing penetration-enhancing composition according to any one of claims 1 - 7.

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