Blood bag continuous extrusion method, device, medium and equipment

Abstract

The invention discloses a blood bag continuous extrusion method and device, a medium and equipment. The method comprises the steps that the blood bag continuous extrusion process is divided into a plurality of extrusion stages; obtaining a target extrusion parameter, and generating a target pressure value corresponding to each extrusion stage; and the current extrusion pressure is collected, the current extrusion pressure is adjusted to the corresponding target pressure value based on the preset control scheme of each extrusion stage, and continuous extrusion is conducted till the preset extrusion ending condition is met. The extrusion process is divided into a plurality of stages, the actual extrusion pressure of a target monitoring point on a mother bag serves as system input, the running speed of a stepping motor is adjusted in real time through a PID algorithm, and therefore the whole extrusion process is controlled to be within a proper pressure range; and after the pressure reaches the target value, the whole extrusion process is subjected to pressure maintaining according to the set small target pressure, so that the preparation efficiency is high, the hemolysis phenomenon is avoided, the quality of the separation process and the product percent of pass are improved, and the risk of abnormal quality is reduced.

Description

Technical Field

[0001] The present invention relates to the field of blood separation equipment, and particularly to a method, device, medium and equipment for continuous extrusion of blood bags. Background Art

[0002] Currently, when separating blood in the medical industry, the blood bag extrusion method is mainly adopted. After centrifugation, whole blood will be stratified into different components such as plasma, platelets and red blood cells. By extruding the blood bag, these different blood components can be transferred to the corresponding component collection blood bags through plastic catheters to achieve blood component separation.

[0003] The traditional blood bag extrusion method uses a cylinder as the power and adjusts the pressure through an air pump for non - continuous blood bag extrusion. The control process uses a single control drive end and cannot detect the real - time pressure of the blood bag. Therefore, it cannot ensure the continuity of the extrusion process and the constant pressure during extrusion. At the same time, it cannot adjust the motor speed in real time, resulting in an uneven extrusion speed during the extrusion process, which not only affects the flow rate stability of blood components, but also easily causes accidents such as hemolysis and blood bag rupture when the extrusion pressure is too high. When the extrusion pressure is too small, it will prolong the extrusion and blood separation time, affect the separation effect of blood components, and increase the risk of quality abnormalities. Summary of the Invention

[0004] The present invention provides a method, device, medium and equipment for continuous extrusion of blood bags, which solves the above - mentioned technical problems.

[0005] In the first aspect of the embodiments of the present invention, a method for continuous extrusion of blood bags is provided. The extrusion mechanism is driven by a stepping motor to extrude a mother bag containing whole blood components, and the different blood components extruded are transferred to the corresponding blood collection bags through pipelines. The method includes the following steps:

[0006] Step 1, dividing the continuous extrusion process of the blood bag into multiple extrusion stages;

[0007] Step 2, obtaining target extrusion parameters, and generating a target pressure value corresponding to each extrusion stage according to the target extrusion parameters. The target extrusion parameters include target blood components, target pipe diameter and the flexibility of the mother bag;

[0008] Step 3, collecting the current extrusion pressure of the mother bag, adjusting the current extrusion pressure to the corresponding target pressure value based on the preset control scheme of each extrusion stage and continuously extruding until the extrusion end condition corresponding to each extrusion stage is reached.

[0009] In the second aspect of the embodiments of the present invention, a computer - readable storage medium is provided, storing a computer program, which when executed by a processor, implements the above - mentioned method for continuous extrusion of blood bags.

[0010] In the third aspect of the embodiments of the present invention, a blood bag continuous extrusion device is provided, including a computer-readable storage medium and a processor. When the processor executes a computer program on the computer-readable storage medium, the steps of the above-mentioned blood bag continuous extrusion method are implemented.

[0011] In the fourth aspect of the embodiments of the present invention, a blood bag continuous extrusion apparatus is provided, including a controller and a stepper motor electrically connected to the controller. The controller drives an extrusion mechanism to extrude a mother bag containing whole blood components through the stepper motor. It is characterized in that the controller specifically includes a division module, a generation module, and a control module.

[0012] The division module is used to divide the blood bag continuous extrusion process into multiple extrusion stages;

[0013] The generation module is used to obtain target extrusion parameters, and generate a target pressure value corresponding to each extrusion stage according to the target extrusion parameters. The target extrusion parameters include target blood components, target pipe diameter, and mother bag flexibility;

[0014] The control module is used to collect the current extrusion pressure of the mother bag, adjust the current extrusion pressure to the corresponding target pressure value based on a preset control scheme for each extrusion stage, and continuously extrude until the extrusion end condition corresponding to each extrusion stage is reached.

[0015] The beneficial effects of the present invention are as follows: The present invention provides a blood bag continuous extrusion method, device, medium, and equipment. On the basis of the original use of extrusion mechanism stroke control and blood bag liquid boundary position control, a new PID control algorithm based on pressure feedback is designed. The entire extrusion process is divided into multiple stages. In the continuous extrusion stage with the longest duration, the actual extrusion pressure of the target monitoring point on the mother bag is used as the system input, and the running speed of the stepper motor is adjusted in real time through the PID algorithm, so as to control the entire extrusion process within a suitable pressure range, and maintain the pressure for the entire extrusion process at a set smaller target pressure after the pressure reaches the target value. It not only has high preparation efficiency, but also does not cause hemolysis, improves the quality of the separation process and the product qualification rate, and reduces the risk of quality abnormalities.

[0016] To make the above objects, features, and advantages of the invention more obvious and understandable, the preferred embodiments of the present invention are specifically described below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for the embodiments. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0018] Figure 1 is a schematic flowchart of the continuous blood bag extrusion method provided in Embodiment 1;

[0019] Figure 2 is the extrusion speed curve corresponding to the complete extrusion process when the target blood component in Embodiment 1 is plasma;

[0020] Figure 3 is the pressure-flow rate curve corresponding to the case where the target blood component in Embodiment 1 is plasma and the pipe diameter is 4 mm;

[0021] Figure 4 is a schematic structural diagram of the continuous blood bag extrusion device provided in Embodiment 2;

[0022] Figure 5 is a schematic structural diagram of the continuous blood bag extrusion equipment provided in Embodiment 3. Detailed Embodiments

[0023] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below in conjunction with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0024] It should be noted that if there is no conflict, the various features in the embodiments of the present invention can be combined with each other, and all are within the scope of protection of the present invention. In addition, although the functional modules are divided in the device schematic diagram and the logical order is shown in the flowchart, in some cases, the steps shown or described can be executed in a different order from the module division in the device or the flowchart. Furthermore, the terms "first", "second", "third", etc. adopted by the present invention do not limit the data and the execution order, but only distinguish the same items or similar items with basically the same functions and effects.

[0025] Figure 1It is a schematic flow chart of a method for continuously squeezing a blood bag provided in Embodiment 1. It can be understood that after the raw blood is unidirectionally centrifuged by a centrifuge under aseptic conditions, each blood component with different specific gravities, including plasma, buffy coat, and red blood cells, will form a layer of its own single component, and then the single blood components formed in different layers in the blood can be collected separately. Specifically, a stepping motor can be used to drive an extrusion mechanism (such as an extrusion plate) to squeeze a mother bag containing whole blood components, so that the extruded different blood components, including plasma, red blood cells, buffy coat, etc., are transferred to corresponding blood collection bags through plastic pipes. In the original technical solution, a stepping screw motor is used to drive the extrusion mechanism to squeeze the blood bag. During the extrusion process, a position control mode is adopted, and the motor running speed is switched between a preset number of speeds by using the stroke position of the extrusion plate and the position of the liquid boundary line of the blood bag. For example, when the stroke position of the extrusion plate becomes larger or the position of the liquid boundary line of the blood bag rises, the motor running speed is reduced. In this way, the real-time pressure received by the blood bag cannot be detected, and the motor speed cannot be adjusted in real time, resulting in an uneven extrusion process, unstable flow rate of blood components, and the inability to stop the extrusion in time when the pressure is too high, which may cause the blood bag to rupture or hemolysis. If the motor running speed is too slow, it will lead to too long separation time and increase the risk of quality abnormality.

[0026] As Figure 1 shown, the method for continuously squeezing a blood bag in this embodiment includes the following steps:

[0027] Step 1, dividing the continuous squeezing process of the blood bag into multiple squeezing stages;

[0028] Step 2, obtaining target extrusion parameters, and generating a target pressure value corresponding to each squeezing stage according to the target extrusion parameters, where the target extrusion parameters include target blood components, target pipe diameter, and flexibility of the mother bag;

[0029] Step 3, collecting the current extrusion pressure of the mother bag, adjusting the current extrusion pressure to the corresponding target pressure value based on the preset control scheme for each squeezing stage and continuously squeezing until the extrusion end condition corresponding to each squeezing stage is reached.

[0030] The above embodiments provide a method for continuous extrusion of a blood bag, which divides the extrusion process into multiple stages and obtains the target pressure value for each stage according to the target extrusion parameters, so as to adjust the actual extrusion pressure to the target pressure value according to the preset control scheme for each extrusion stage. For example, taking the actual extrusion pressure at the target monitoring point on the mother bag as the system input, the running speed of the stepping motor is adjusted in real time through the PID algorithm, so as to control the entire extrusion process within a suitable pressure range. At the same time, after the pressure reaches the target value, the entire extrusion process can be kept under pressure according to the set smaller target pressure, which not only has high preparation efficiency, but also does not cause hemolysis, improves the quality of the separation process and the product qualification rate, and reduces the risk of quality anomalies.

[0031] The following uses specific embodiments to elaborate on each step of the above method in detail.

[0032] It can be understood that in a preferred embodiment, the continuous extrusion process of the blood bag is divided into three extrusion stages, namely the initial extrusion stage, the constant-pressure continuous extrusion stage, and the pressure-holding stage.

[0033] Specifically, in the initial extrusion stage, since the extrusion plate is not initially in contact with the mother bag, at this time, the stepping motor is controlled by the first motor running speed to drive the extrusion mechanism to extrude forward at a relatively fast speed until the pressure value at the target monitoring point on the mother bag reaches the first target pressure value. During this process, the extrusion plate will maintain this speed and extrude forward uniformly, which can improve the efficiency of the entire extrusion process. Taking the target blood component to be extruded as plasma as an example, the value range of the first target pressure value is 0.2N - 0.5N, such as 0.3N. At this time, the forward speed of the extrusion plate can be 8 - 12mm / s, such as 10mm / s.

[0034] Then it enters the constant-pressure continuous extrusion stage. In the constant-pressure continuous extrusion stage, the current extrusion pressure of the mother bag is collected at a preset frequency, and the current extrusion pressure is compared with the corresponding second target pressure value. According to the comparison result, the PID control method is used to adjust the second motor running speed of the stepping motor in real time until the preset extrusion end condition is reached, such as the current weight of the target blood collection bag reaches the preset weight value. In other embodiments, the color of the current mother bag image can also be collected and analyzed by a color recognition device. If the current mother bag image does not contain the color corresponding to the target blood component, it means that all the target blood components in the mother bag have been extruded into the corresponding blood collection bag.

[0035] It can be understood that the PID control method consists of proportional control (P), integral control (I), and derivative control (D). In a single-parameter control system such as constant pressure control, it has the characteristics of stable operation and convenient adjustment. In this embodiment, the target value of PID control is the second target pressure value of the target monitoring point on the mother bag, the actual value is the actual extrusion pressure fed back by the pressure sensor, and the output value of PID is the running speed of the stepping motor, thereby controlling the movement of the stepping motor. When the stepping motor moves, it drives the extrusion plate to move into contact with the mother bag. As the stepping motor moves, the force exerted by the extrusion plate on the mother bag becomes larger and larger, and the actual extrusion pressure value collected by the pressure sensor will also become larger. When there is sufficient extrusion pressure, the target blood component in the mother bag will be extruded, and the separation process starts from this point. At the same time that the target blood component in the mother bag is extruded, the current extrusion pressure will also change, thereby achieving precise control of the extrusion pressure through the PID method.

[0036] Still taking the target blood component to be separated as plasma as an example, when the current extrusion pressure value at the monitoring point on the mother bag reaches 0.3 N, after a short stop of the extrusion plate, the PID control takes effect. At this time, the extrusion plate enters the constant pressure continuous extrusion state, and the current extrusion pressure value at the monitoring point will continue to increase. After reaching the second target pressure value, such as 3 N, it will maintain at about 3 N to extrude the mother bag. During this process, the forward speed of the extrusion plate will fluctuate between 0 and 1 mm / s.

[0037] Finally, it enters the pressure holding stage. In the pressure holding stage, calculate the difference between the current extrusion pressure of the mother bag and the corresponding third target pressure value, and generate a third motor running speed according to the difference, and control the extrusion mechanism to extrude the mother bag at a constant speed with the third motor running speed until the preset pressure holding duration is reached. It can be understood that the second target pressure value, the third target pressure value, and the first target pressure value decrease in sequence; and the first motor running speed, the second motor running speed, and the third motor running speed decrease in sequence.

[0038] Still taking the target blood component to be separated as plasma as an example, when the weight of the extruded plasma is close to the target value, the extrusion plate will reduce its speed to 1 mm / s for uniform extrusion. At this time, the current extrusion pressure value at the monitoring point will be lower than 1 N, thereby preventing red blood cells from being squeezed into the plasma due to inertia at the end of the extrusion separation, resulting in red blood cell contamination. The extrusion speed curve (i.e., the forward speed curve of the extrusion plate) of the complete extrusion process is as Figure 2 shown, where the vertical coordinate is the forward speed of the extrusion plate (mm / s), and the horizontal coordinate is the time (s).

[0039] It can be understood that in specific embodiments, a thin-film pressure sensor can be adopted and disposed on the side of the extrusion plate close to the mother bag, so as to continuously detect the actual extrusion pressure when the mother bag is extruded, and complete the continuous extrusion process of the whole blood bag.

[0040] In a preferred embodiment, according to the differences in the target blood components to be separated, the diameters of the plastic pipes connected to the target blood collection bags, and the flexibility of the mother bags (usually determined by the material and thickness), different target pressure values will be adopted in different extrusion stages.

[0041] In a preferred embodiment, the specific method for generating the first target pressure value in the initial extrusion stage is as follows:

[0042] Collect historical blood bag extrusion data, and establish a first mapping relationship table according to the historical blood bag extrusion data. The first mapping relationship table includes the initial pressure values corresponding to the start separation moments of different blood components under different pipe diameters and / or different mother bag flexibilities.

[0043] Query the first mapping relationship table, and use the initial pressure value corresponding to the target blood component, the target pipe diameter, and the mother bag flexibility as the first target pressure value.

[0044] In a preferred embodiment, the specific method for generating the second target pressure value in the constant-pressure continuous extrusion stage is as follows:

[0045] Collect historical blood bag extrusion data, and fit the pressure-flow rate curves of different blood components under different pipe diameters and / or different mother bag flexibilities according to the historical blood bag extrusion data. The pressure-flow rate curves include the corresponding relationship between the extrusion pressure and the flow rate of the blood components.

[0046] Use the inflection point pressure value of the target pressure-flow rate curve corresponding to the target extrusion parameters as the second target pressure value in the constant-pressure continuous extrusion stage. Before the inflection point pressure value, the flow rate of the target blood component increases monotonically with the extrusion pressure, and after the inflection point pressure value, the change range of the flow rate of the target blood component is less than a preset value.

[0047] It is understandable that in this embodiment, a corresponding pressure-flow rate curve is established for each blood component. Specifically, when the extrusion mechanism is driven by a stepper motor to extrude the mother bag containing whole blood components, the different blood components extruded will be transferred to the corresponding blood collection bags through their respective plastic pipes. Affected by the viscosity of each blood component, the diameter of the plastic pipe, and the flexibility of the mother bag, the pressure-flow rate curve fitted by the extrusion pressure applied to the mother bag and the liquid flow rate in the plastic pipe will have different inflection point pressure values. That is, before this inflection point pressure value, the flow rate of the target blood component increases monotonically with the extrusion pressure, and after this inflection point pressure value, the change range of the flow rate of the target blood component is less than a preset value. For example, the flow rate basically remains unchanged. In other words, when the extrusion pressure reaches a certain value, even if the extrusion pressure is further increased, the liquid flow rate in the plastic pipe will not increase, but instead, problems such as blood bag rupture and hemolysis will occur as the extrusion pressure continues to increase.

[0048] As Figure 3 shown, when the target blood component to be separated is plasma and the diameter of the plastic pipe connected to the target blood collection bag is 4 mm, the fitted pressure-flow rate curve is shown, where the ordinate is the liquid flow rate in the pipe (g / s) and the abscissa is the current extrusion pressure (N) at the target monitoring point on the mother bag. Through experimental data, when the pressure value at the monitoring point reaches 3 N, the flow rate of the blood component in the pipe remains at 10 g / s. When the pressure continues to increase, the flow rate of the blood component in the pipe does not change. Therefore, when the pressure value at the monitoring point reaches 3 N, the flow rate of the blood component in the pipe reaches the fastest. At this time, if the pressure is further increased, the pressure on the blood bag will continue to increase, leading to the risk of blood bag rupture. Therefore, there is no need to further increase the pressure at this time, and by using PID control to keep the actual pressure value at the monitoring point around 3 N, the highest extrusion efficiency can be satisfied. When separating plasma using the above method, with the pressure at the 3 N monitoring point as the target pressure, 20 bags of blood products were prepared. The maximum value of pressure detection was 3.5 N, and all the products prepared met the requirements.

[0049] It is understandable that in a preferred embodiment, the specific method for generating the third target pressure value in the pressure-holding stage is as follows:

[0050] Collect historical blood bag extrusion data, and establish a second mapping relationship table according to the historical blood bag extrusion data. The second mapping relationship table includes the warning pressure values corresponding to different blood components being extruded into interfering blood components at different pipe diameters and / or different mother bag flexibilities.

[0051] Query the second mapping relationship table, and use the warning pressure value corresponding to the target blood component, the target pipe diameter, and the mother bag flexibility as the third target pressure value. Thus, by adopting a segmented extrusion method according to the actual situation, not only the extrusion efficiency can be improved, but also the blood bag can be prevented from being squeezed and broken, or problems such as hemolysis can be avoided.

[0052] It should be understood that the sequence numbers of the steps in the above embodiments do not imply the order of execution. The order of execution of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present invention.

[0053] The embodiments of the present invention also provide a computer-readable storage medium storing a computer program, which, when executed by a processor, implements the above-mentioned method for continuously squeezing a blood bag.

[0054] Figure 4 It is a schematic structural diagram of the blood bag continuous squeezing device provided by Embodiment 2. The blood bag continuous squeezing device of this embodiment includes a controller and a stepping motor electrically connected to the controller. The controller drives an extrusion mechanism to squeeze a mother bag containing whole blood components through the stepping motor, as Figure 4 shown. The controller specifically includes a division module 100, a generation module 200, and a control module 300.

[0055] The division module 100 is used to divide the blood bag continuous squeezing process into multiple squeezing stages;

[0056] The generation module 200 is used to obtain target extrusion parameters and generate target pressure values corresponding to each squeezing stage according to the target extrusion parameters. The target extrusion parameters include target blood components, target pipe diameters, and the flexibility of the mother bag;

[0057] The control module 300 is used to collect the current extrusion pressure of the mother bag, adjust the current extrusion pressure to the corresponding target pressure value based on the preset control scheme for each squeezing stage, and continuously squeeze until the extrusion end condition corresponding to each squeezing stage is reached.

[0058] The above embodiments provide a blood bag continuous squeezing device, which divides the squeezing process into multiple stages, obtains the target pressure value for each stage according to the target extrusion parameters, and thus adjusts the actual extrusion pressure to the target pressure value according to the preset control scheme for each squeezing stage. For example, taking the actual extrusion pressure at the target monitoring point on the mother bag as the system input, the running speed of the stepping motor is adjusted in real time through the PID algorithm, so as to control the entire squeezing process within a suitable pressure range. At the same time, after the pressure reaches the target value, the entire squeezing process can be maintained at a set smaller target pressure, which not only has high preparation efficiency, but also does not cause hemolysis, improves the quality of the separation process and the product qualification rate, and reduces the risk of quality anomalies.

[0059] In a preferred embodiment, the control module 300 specifically includes:

[0060] The first control unit is used to control the stepping motor to drive the extrusion mechanism to move forward at a constant speed during the initial extrusion stage until the current extrusion pressure of the mother bag reaches the first target pressure value;

[0061] The second control unit is used to collect the current extrusion pressure of the mother bag at a preset frequency during the constant-pressure continuous extrusion stage, compare the current extrusion pressure with the corresponding second target pressure value, and use the PID control method to adjust the second motor operating speed of the stepping motor in real time according to the comparison result until the preset extrusion end condition is reached;

[0062] The third control unit is used to calculate the difference between the current extrusion pressure of the mother bag and the corresponding third target pressure value during the pressure-holding stage, and generate a third motor operating speed according to the difference, and control the extrusion mechanism to extrude the mother bag at a constant speed with the third motor operating speed until the preset pressure-holding duration is reached.

[0063] In a preferred embodiment, the generation module 200 specifically includes:

[0064] The first construction unit is used to collect historical blood bag extrusion data and establish a first mapping table according to the historical blood bag extrusion data. The first mapping table includes the initial pressure values corresponding to the starting separation moments of different blood components under different pipe diameters and / or different mother bag flexibility;

[0065] The first query unit is used to query the first mapping table and use the initial pressure value corresponding to the target blood component, the target pipe diameter, and the mother bag flexibility as the first target pressure value.

[0066] In a preferred embodiment, the generation module 200 further includes:

[0067] The second construction unit is used to collect historical blood bag extrusion data and fit the pressure-flow rate curves of different blood components under different pipe diameters and / or different mother bag flexibility. The pressure-flow rate curves include the corresponding relationship between the extrusion pressure and the flow rate of the blood components;

[0068] The second query unit is used to use the inflection point pressure value of the target pressure-flow rate curve corresponding to the target extrusion parameter as the second target pressure value during the constant-pressure continuous extrusion stage. Before the inflection point pressure value, the flow rate of the target blood component increases monotonically with the extrusion pressure, and after the inflection point pressure value, the change amplitude of the flow rate of the target blood component is less than the preset value.

[0069] In a preferred embodiment, the generation module 200 further includes:

[0070] A third construction unit, configured to collect historical blood bag extrusion data and establish a second mapping relation table according to the historical blood bag extrusion data, where the second mapping relation table includes warning pressure values corresponding to different blood components being extruded into interfering blood components at different pipe diameters and / or different flexibility of the mother bag;

[0071] A third query unit, configured to query the second mapping relation table and use the warning pressure value corresponding to the target blood component, the target pipe diameter, and the flexibility of the mother bag as the third target pressure value.

[0072] An embodiment of the present invention further provides a blood bag continuous extrusion device, including a computer-readable storage medium and a processor. When the processor executes a computer program on the computer-readable storage medium, the steps of the above-mentioned blood bag continuous extrusion method are implemented.

[0073] Figure 5 FIG. 10 is a schematic structural diagram of the blood bag continuous extrusion device provided in Embodiment 3 of the present invention. As Figure 5 shown, the blood bag continuous extrusion device 8 of this embodiment includes: a processor 80, a readable storage medium 81, and a computer program 82 stored in the readable storage medium 81 and executable on the processor 80. When the processor 80 executes the computer program 82, the steps in the above-mentioned various method embodiments are implemented, such as Figure 1 the steps shown. Alternatively, when the processor 80 executes the computer program 82, the functions of each module in the above-mentioned various device embodiments are implemented, such as Figure 4 the functions of the modules shown.

[0074] Exemplarily, the computer program 82 can be divided into one or more modules. The one or more modules are stored in the readable storage medium 81 and executed by the processor 80 to complete the present invention. The one or more modules can be a series of computer program instruction segments capable of performing specific functions, and the instruction segments are used to describe the execution process of the computer program 82 in the blood bag continuous extrusion device 8.

[0075] The blood bag continuous extrusion device 8 may include, but is not limited to, a processor 80 and a readable storage medium 81. Those skilled in the art can understand that Figure 5 this is only an example of the blood bag continuous extrusion device 8 and does not constitute a limitation on the blood bag continuous extrusion device 8. It may include more or fewer components than shown in the figure, or combine certain components, or different components. For example, the blood bag continuous extrusion device may further include a power management module, an arithmetic processing module, an input / output device, a network access device, a bus, etc.

[0076] The so-called processor 80 may be a central processing unit (CPU), or may also be other general-purpose processors, digital signal processors (DSPs), application specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc.

[0077] The readable storage medium 81 may be an internal storage unit of the blood bag continuous extrusion device 8, such as the hard disk or memory of the blood bag continuous extrusion device 8. The readable storage medium 81 may also be an external storage device of the blood bag continuous extrusion device 8, such as a plug-in hard disk, a smart media card (SMC), a secure digital (SD) card, a flash card, etc. equipped on the blood bag continuous extrusion device 8. Further, the readable storage medium 81 may also include both the internal storage unit and the external storage device of the blood bag continuous extrusion device 8. The readable storage medium 81 is used to store the computer program and other programs and data required by the blood bag continuous extrusion device. The readable storage medium 81 may also be used to temporarily store data that has been output or is to be output.

[0078] Those skilled in the art can clearly understand that, for the convenience and conciseness of description, only the above division of each functional unit and module is used as an example. In actual applications, the above functions can be allocated to different functional units and modules as needed, that is, the internal structure of the device is divided into different functional units or modules to complete all or part of the functions described above. Each functional unit and module in the embodiment may be integrated in a processing unit, or each unit may exist physically alone, or two or more units may be integrated in one unit. The above integrated unit may be implemented in the form of hardware or in the form of a software functional unit. In addition, the specific names of each functional unit and module are only for the convenience of mutual distinction and do not limit the protection scope of this application. The specific working processes of the units and modules in the above system may refer to the corresponding processes in the foregoing method embodiments and will not be elaborated herein.

[0079] In the above embodiments, the descriptions of the various embodiments have their own emphases. For parts not detailed or recorded in a certain embodiment, reference may be made to the relevant descriptions of other embodiments.

[0080] Those of ordinary skill in the art can realize that the units and method steps of the examples described in combination with the embodiments disclosed herein can be implemented by electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are executed in a hardware or software manner depends on the specific application and design constraints of the technical solution. Professional technicians can use different methods for each specific application to implement the described functions, but such implementation should not be considered to exceed the scope of the present invention.

[0081] In the embodiments provided by the present invention, it should be understood that the disclosed device / terminal device and method can be implemented in other ways. For example, the device / terminal device embodiments described above are merely illustrative. For example, the division of the modules or units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed couplings or direct couplings or communication connections to each other can be through some interfaces. The indirect couplings or communication connections of the devices or units can be in electrical, mechanical or other forms.

[0082] The units described as separate components may or may not be physically separated. The components shown as units may or may not be physical units, that is, they can be located in one place, or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0083] In addition, the functional units in the various embodiments of the present invention can be integrated into one processing unit, or each unit can exist physically alone, or two or more units can be integrated into one unit. The above-mentioned integrated units can be implemented in the form of hardware or in the form of software functional units.

[0084] The present invention is not limited only to what is described in the specification and embodiments. Therefore, for those skilled in the art, additional advantages and modifications can be easily achieved. Therefore, without departing from the spirit and scope of the general concept defined by the claims and their equivalents, the present invention is not limited to the specific details, representative devices, and illustrated examples shown and described here.

Claims

1. A continuous blood bag extrusion method, which drives an extrusion mechanism by a stepper motor to extrude a mother bag containing whole blood components, and transfers the extruded different blood components to corresponding blood collection bags through pipelines, characterized in that The method includes the following steps: Step 1, dividing the continuous extrusion process of the blood bag into multiple extrusion stages; Step 2, obtaining target extrusion parameters, and generating target pressure values corresponding to each extrusion stage according to the target extrusion parameters, where the target extrusion parameters include target blood components, target pipe diameters, and the flexibility of the mother bag; Step 3, collecting the current extrusion pressure of the mother bag, adjusting the current extrusion pressure to the corresponding target pressure value based on the preset control scheme for each extrusion stage and continuously extruding until the extrusion end condition corresponding to each extrusion stage is reached.

2. The continuous squeezing method of a blood bag according to claim 1, characterized in that, It includes three extrusion stages, namely the initial extrusion stage, the constant-pressure continuous extrusion stage, and the pressure-holding stage. In the initial extrusion stage, controlling the stepping motor to drive the extrusion mechanism to move forward at a uniform speed with the running speed of the first motor until the current extrusion pressure of the mother bag reaches the first target pressure value; In the constant-pressure continuous extrusion stage, collecting the current extrusion pressure of the mother bag at a preset frequency, comparing the current extrusion pressure with the corresponding second target pressure value, and using the PID control method to adjust the running speed of the second motor of the stepping motor in real time according to the comparison result until the preset extrusion end condition is reached; In the pressure-holding stage, calculating the difference between the current extrusion pressure of the mother bag and the corresponding third target pressure value, and generating the running speed of the third motor according to the difference, controlling the extrusion mechanism to extrude the mother bag at a uniform speed with the running speed of the third motor until the preset pressure-holding duration is reached.

3. The continuous blood bag squeezing method according to claim 2, wherein The second target pressure value, the third target pressure value, and the first target pressure value decrease in sequence; and the running speed of the first motor, the running speed of the second motor, and the running speed of the third motor decrease in sequence.

4. The continuous blood bag squeezing method according to claim 2, wherein, The preset extrusion end condition in the constant-pressure continuous extrusion stage includes that the current weight of the target blood collection bag reaches a preset weight value and / or the current mother bag image does not contain the color corresponding to the target blood component.

5. The continuous blood bag squeezing method according to any one of claims 2-4, characterized in that, Specifically, generating the first target pressure value in the initial extrusion stage: Collecting historical blood bag extrusion data, and establishing a first mapping table according to the historical blood bag extrusion data. The first mapping table includes the initial pressure values corresponding to the starting separation moments of different blood components under different pipe diameters and / or different flexibilities of the mother bag; Querying the first mapping table, and taking the initial pressure value corresponding to the target blood component, the target pipe diameter, and the flexibility of the mother bag as the first target pressure value.

6. The continuous blood bag squeezing method according to claim 5, characterized in that, Specifically, generating the second target pressure value in the constant-pressure continuous extrusion stage: Collecting historical blood bag extrusion data, and fitting the pressure-flow rate curves of different blood components under different pipe diameters and / or different flexibilities of the mother bag according to the historical blood bag extrusion data. The pressure-flow rate curve includes the corresponding relationship between the extrusion pressure and the flow rate of the blood component; Taking the inflection point pressure value of the target pressure-flow rate curve corresponding to the target extrusion parameters as the second target pressure value in the constant-pressure continuous extrusion stage. Before the inflection point pressure value, the flow rate of the target blood component increases monotonically with the extrusion pressure, and after the inflection point pressure value, the change range of the flow rate of the target blood component is less than the preset value.

7. The method for continuously squeezing a blood bag according to claim 6, wherein, Specifically, the third target pressure value in the holding pressure stage is as follows: Collect historical blood bag extrusion data, and establish a second mapping relationship table according to the historical blood bag extrusion data. The second mapping relationship table includes the warning pressure values corresponding to the moments when different blood components are extruded into interfering blood components under different pipe diameters and / or different flexibility of the mother bag. Query the second mapping relationship table, and use the warning pressure value corresponding to the target blood component, the target pipe diameter, and the flexibility of the mother bag as the third target pressure value.

8. A continuous blood bag extrusion device, comprising a controller and a stepper motor electrically connected to the controller, wherein the controller drives an extrusion mechanism to extrude a mother bag containing whole blood components through the stepper motor, and is characterized in that, The controller includes a division module, a generation module, and a control module. The division module is used to divide the continuous extrusion process of the blood bag into multiple extrusion stages. The generation module is used to obtain target extrusion parameters, and generate target pressure values corresponding to each extrusion stage according to the target extrusion parameters. The target extrusion parameters include the target blood component, the target pipe diameter, and the flexibility of the mother bag. The control module is used to collect the current extrusion pressure of the mother bag, adjust the current extrusion pressure to the corresponding target pressure value based on the preset control scheme for each extrusion stage, and continuously extrude until the extrusion end condition corresponding to each extrusion stage is reached.

9. A computer-readable storage medium storing a computer program, characterized in that, When the computer program is executed by a processor, it implements the blood bag continuous extrusion method according to any one of claims 1-7 above.

10. A continuous blood bag extrusion device, comprising a computer-readable storage medium and a processor, characterized in that, When the processor executes the computer program on the computer-readable storage medium, it implements the steps of the blood bag continuous extrusion method according to any one of claims 1-7 above.

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