Intelligent neural electric regulation and medicine collaborative treatment system and control method

Abstract

The invention discloses an intelligent nerve electrical regulation and drug collaborative treatment system and a control method. The system comprises a composite electrode patch, a nerve electrical regulation host and an App TinyAI optimization module. The composite electrode patch is composed of a conductive hydrogel layer, a drug loading layer and the like, and electrical stimulation and full drug release delivery can be carried out at the same time. The nerve electrical regulation host is internally provided with a plurality of treatment programs of targeted electrical regulation formulas, and tissue impedance is rapidly reduced by adopting an impedance reduction formula, so that the electrical regulation formulas and medicines can reach deep focuses more easily for collaborative treatment. The App TinyAI automatically provides and optimizes a personalized treatment scheme based on pain data of a patient, and continuously trains and updates an AI model through cloud big data to improve the curative effect. Preliminary clinical verification of the system shows that the improvement rate of QOLSP (VAS + PGIC) score is improved by 42% compared with that of a traditional method, and no skin adverse reaction exists.

Description

Technical Field

[0001] The present invention relates to the technical field of neuromodulation and drug delivery, and particularly to an intelligent neuromodulation and drug synergistic treatment system and a control method. Background Art

[0002] Physical and drug therapies have played a quite important role in the history of medical development in China. With the development of modern medicine, especially the new discoveries and new understandings of neuromodulation medicine and traditional Chinese and Western medicines, physical therapy and drug therapy have been endowed with newer technologies and more precise targets, thereby improving the curative effect. The indications also cover multiple fields such as dermatology, vascular surgery, orthopedics, respiratory medicine, digestive medicine, gynecology, pediatrics, etc., and have good therapeutic effects on various pains, inflammations, vascular diseases, skin diseases, etc. However, the currently known treatments have the following problems and challenges: 1. Due to the impedance of the skin surface layer, especially the stratum corneum, it is difficult for drugs to break through the impedance. Whether it is conductive or non-conductive drugs, they need to enter the deep layer of the skin through the passive diffusion of water-soluble substances in the stratum corneum and appendageal pathways such as hair follicles / sweat glands, etc. Therefore, the transdermal drug penetration speed and depth are limited, affecting the curative effect; 2. Especially for many transdermal plant and animal drugs, because they do not have conductivity, their drug penetration depth and speed are worse than those of non-conductive drugs, and usually the curative effect is also worse; In order to improve penetration, some technologies, without affecting the drug properties, enhance the electron transport ability of the drug carrier by using conductive drug excipients or compounding graphene flakes or carbon nanotubes at a ratio of 0.1%-0.5%, but no matter what, they cannot escape the limitations of the speed and depth of passive penetration of biological carriers; 3. Some electrotherapy technologies use hydrogels mixed with drugs, but due to the adhesion of the gel to the drugs, the release of the drugs is limited, and at most only 1% of the drugs will be released, and there is basically no drug effect; 4. Some hydrogel electrode patches have a structure with a plaster added, but there are several important defects: (1) The structural defect makes it impossible to retain liquid drugs, and the liquid medicine cannot be used; (2) There is no special electric field to reduce the impedance of the stratum corneum to promote the speed and depth of drug penetration; (3) For non-conductive plasters, due to the isolation of the plasters, charges cannot reach the stratum corneum to change its impedance and promote the drug penetration speed and depth, and it is still limited by biological passive penetration; 5. Existing electrotherapy technologies do not have a particularly optimized impedance-reducing electric field for breaking through the impedance of the stratum corneum, and the effect of promoting drug penetration is not good; 6. There is no precedent for using electro-neuromodulation and drugs with similar or the same targeting effects to perform in-depth synergistic optimization treatment while reducing the impedance of the cerebral cortex and subcutaneous tissues.

[0003] Therefore, the existing technology still needs to be improved. Summary of the Invention

[0004] The present invention aims to provide an intelligent neuroelectrical regulation and drug synergistic treatment system and a control method to solve the above technical problems at one stroke. The technical solutions adopted by the present invention are as follows:

[0005] A neuroelectrical regulation and drug synergistic treatment system, which includes: a composite electrode patch, a neuroelectrical regulation main unit, and an App TinyAI optimization module. The composite electrode patch is composed of a conductive hydrogel layer, a conductive film, a drug loading layer, a peelable double-sided adhesive, an electrode connection button, and an integrated substrate; the neuroelectrical regulation main unit contains multiple treatment programs composed of several basic treatment formulas with different targeting effects and an electroregulation basic impedance reduction formula; the App TinyAI optimization module automatically optimizes the symptomatic treatment based on the specific pain data of the patient, the electroregulation targeting data, and the drug targeting data to generate a personalized treatment course prescription, and continuously adjusts and optimizes the treatment course prescription through intelligent machine learning of the periodic efficacy follow-up data.

[0006] In the neuroelectrical regulation and drug synergistic treatment system, the drug loading layer can load plaster or liquid medicine without loss. The loading layer can be a general conductive material or a non-conductive material for conductive drugs, and the loading layer can be peeled and replaced.

[0007] In the neuroelectrical regulation and drug synergistic treatment system, the neuroelectrical regulation main unit contains multiple core treatment programs, an electroregulation basic impedance reduction formula, and a function control and implementation algorithm logic, and the core treatment programs are composed of several electroregulation basic treatment formulas with different targeting effects.

[0008] The described neuroelectrical regulation and drug combination therapy system, wherein the basic electroregulation therapy formula includes a peripheral mechanism formula, an extra-segmental mechanism formula, a neurochemical substance promotion formula, a blood circulation promotion formula, a relaxation formula, and a muscle strengthening formula, etc. The peripheral mechanism formula targets the regulation of peripheral nerves. Through specially designed electroregulation signals, it weakens pain signals and blocks the transmission of pain signals to the central nervous system to achieve analgesic effects. The extra-segmental mechanism formula uses specially designed electroregulation signals to induce somatic sensory A-δ activity, activate the descending pain inhibitory pathway, and inhibit the descending pain promotion pathway to produce analgesic effects for several hours. The neurochemical substance promotion formula uses specially designed electroregulation signals to transmit stimuli through sensory nerves to the central nervous system to promote the release of neurochemical mediators such as serotonin, acetylcholine, norepinephrine, GABA, and endorphins to achieve continuous anti-inflammatory and analgesic effects. The blood circulation promotion formula uses specially designed electroregulation signals to stimulate motor nerves to drive the expansion and contraction of muscles to promote the rapid flow of blood and facilitate recovery. The relaxation formula uses specially designed electroregulation signals to stimulate motor nerves to drive the movement of muscles and joints to release the tension and pressure therein to achieve rehabilitation and analgesic effects. The muscle strengthening formula uses specially designed electroregulation signals to stimulate motor nerves to drive muscles to perform strength and endurance simulation exercises to enhance muscle strength and endurance and promote muscle growth at the same time. The basic impedance reduction formula temporarily damages the skin surface layer, especially the high-impedance tissue of the stratum corneum, and rapidly polarizes the subcutaneous tissue through specially designed electroregulation signals, enabling each electroregulation basic therapy formula and drug formula of the core treatment program to pass through and penetrate deeply.

[0009] A control method for an intelligent neuroelectrical regulation and drug combination therapy system, wherein the App TinyAI optimization module enables the user to input pain data before starting treatment and perform machine learning, and combines electroregulation targeted therapy effect data and drug targeted therapy effect data for optimal intelligent matching to ensure that the treatment programs and drugs for the matched combination therapy have similar or complementary targeted therapy effects, and finally generates a personalized treatment course prescription containing several optimal treatment programs, usage methods, and treatment cycles according to the symptoms and presents it to the user for treatment according to the prescription.

[0010] The control method for the intelligent neuroelectrical regulation and drug combination therapy system, wherein before the user starts treatment, the neuroelectrical regulation main unit needs to be connected to the composite electrode patch first, an appropriate amount of plaster or lotion is placed on the drug loading layer, and then the composite electrode patch is placed on the treatment site.

[0011] Control method of the intelligent neural electroregulation and drug synergistic therapy system. When the user follows the treatment course prescription issued by the App TinyAI optimization module and selects a treatment program to start the treatment, the neural electroregulation host will first detect whether the composite electrode patch is in good contact with the skin and prompt the user with the flashing or color change of an LED light. Only when the contact is good can the treatment be started.

[0012] Control method of the intelligent neural electroregulation and drug synergistic therapy system. After the user starts the treatment, the firmware of the neural electroregulation host will drive the hardware to continuously output the corresponding electroregulation impedance reduction mode according to the basic impedance reduction formula to greatly reduce the impedance of the cortex and subcutaneous tissues. At the same time, it will drive the hardware to output the corresponding electroregulation treatment mode according to the basic treatment formula in the treatment program. The electroregulation treatment formula and drug molecules will be driven by the current to quickly reach the target of the deep lesion for synergistic treatment.

[0013] Control method of the intelligent neural electroregulation and drug synergistic therapy system. The App TinyAI optimization module periodically visits the user's treatment progress and feedback according to the QOLSP (Quality of Life in Pain Scale) that combines VAR (Visual Analogue Scale) and PGIC (Patient Global Impression of Change), and stores these data of all users for background big data machine learning and efficacy evaluation. It forms index tables such as gender group, age group, disease, efficacy score, treatment course, number of adjustments, adjustment history, treatment program group, drugs, etc. and continuously updates them, so that the search engine of the App TinyAI optimization module can quickly obtain the data required in the treatment course optimization algorithm decision. When necessary, the App TinyAI optimization module will adjust and optimize the treatment course and treatment program for the user, and synchronize data with the cloud service platform.

[0014] Control method of the intelligent neural electroregulation and drug synergistic therapy system. Through machine learning of the final personalized optimized treatment course prescription data corresponding to different diseases of all patients, the optimal synergistic treatment drug is found, and the synergistic treatment and efficacy are continuously optimized, while synchronizing data with the cloud service platform.

[0015] Control method of the intelligent neural electroregulation and drug synergistic therapy system. The App TinyAI optimization module (300) synchronizes the data and analysis results collected from the client, which have been cleaned, filtered, and regularized, to the cloud service platform in real time. The cloud platform AI conducts big data learning and training on all user data and regularly updates the new parameters and models obtained from the training to the TinyAI on the client, so that the optimization operation of the TinyAI on the client always has the support of big data.

[0016] Beneficial effects: Compared with the prior art, the present invention provides an intelligent neural electroregulation and drug synergistic treatment system and control method. The intelligent neural electroregulation and drug synergistic treatment system includes: a composite electrode patch, a neural electroregulation host, and an App TinyAI optimization module. The App TinyAI optimization module automatically optimizes the symptomatic treatment based on the specific pain data, electroregulation targeting data, and drug targeting data provided by the patient to generate a personalized treatment course prescription. The user selects the corresponding treatment program according to the prescription and conducts treatment through the intelligent neural electroregulation and drug synergistic treatment system. Under the action of the electroregulation-based impedance reduction formula continuously output by the neural electroregulation host, the impedance of the cortex and subcutaneous tissue is greatly reduced, enabling the electroregulation-based treatment formula output by the neural electroregulation host and the drug molecules on the drug loading layer of the composite electrode patch to quickly reach the deeper lesion target sites for synergistic treatment. The App TinyAI optimization module also continuously adjusts and optimizes the treatment course prescription through intelligent machine learning of periodic efficacy follow-up data to achieve the best therapeutic effect. Clinical verification shows that the improvement rate of the QOLSP (VAS+PGIC) score of this system is 42% higher than that of the traditional method, and there are no skin adverse reactions. Brief Description of the Drawings

[0017] Figure 1 This is a diagram of the intelligent neural electroregulation and drug synergistic treatment system provided by the present invention, which includes schematic diagrams of subsystems such as a composite electrode patch, a neural electroregulation host, and an App TinyAI optimization module.

[0018] Figure 2 This is a diagram of the neural electroregulation host provided by the present invention.

[0019] Figure 3 This is the App TinyAI optimization module provided by the present invention. Detailed Description of the Embodiments

[0020] The present invention provides an intelligent neural electroregulation and drug synergistic treatment system. To make the purpose, technical solution, and effects of the present invention clearer and more definite, the following further describes the present invention in detail with reference to the accompanying drawings and by way of examples. It should be understood that the specific examples described herein are only used to explain the present invention and are not used to limit the present invention.

[0021] In the present invention, suffixes such as "module", "subsystem", "component", or "unit" used to represent elements are only for the convenience of explaining the present invention and have no specific meaning in themselves. Therefore, "module", "subsystem", "component", or "unit" can be used interchangeably.

[0022] The following further describes the content of the invention with reference to the accompanying drawings and through the description of the embodiments.

[0023] Please refer to Figure 1 , the intelligent wearable physiotherapy device provided in this embodiment includes: a composite electrode patch (100), a nerve electroregulation host (200), and an App TinyAI optimization module (300). The composite electrode patch (100) is composed of a conductive hydrogel layer (110), a conductive film (120), a drug loading layer (130), a peelable double-sided adhesive (140), an electrode connection button (150), and an integrated substrate (160). As Figure 2 , the nerve electroregulation host (200) includes a plurality of treatment programs and electroregulation basic impedance reduction formulas composed of several electroregulation basic treatment formulas with different targeting effects. Figure 3 , the App TinyAI optimization module (300) includes a human-computer interaction unit, an electroregulation host interaction unit, a prescription optimization unit, a QOLSP efficacy evaluation unit, a TinyML small machine learning unit, a cloud platform interaction unit, a local database, a BLE Bluetooth control unit, etc.

[0024] As Figure 1 , since the drug loading layer (130) uses water-absorbent soft non-woven fabric, it can retain plasters and potions without losing the drugs. When the drug loading layer comes into contact with the skin, the drugs can be released to the skin. The drug loading layer can be a general conductive material, or a non-conductive material can be used for conductive drugs to reduce material costs. Since the drug loading layer and the conductive film are pasted with an easily peelable double-sided adhesive, the drug loading layer can be replaced. Since the drug loading layer is surrounded by conductive hydrogel, the composite electrode patch is easy to paste on the skin while isolating the drugs in different polar parts to avoid short circuit and make the electroregulation ineffective. The design of this embodiment ingeniously solves the problems of inability to retain traditional Chinese medicine water, short circuit failure, usability, producibility, and cost.

[0025] As Figure 2, the neuroelectrical regulation host (200) contains hardware components such as a microprocessor, a detection circuit, an electrical regulation analog circuit, BLE Bluetooth, SRAM memory, Flash memory, USB, UART, a button interface, and a button cell interface. The two button cell interfaces represent different polarities, and the button cell interface can also be replaced with a bipolar socket and output through their respective wires. Among them, the "-" and "+" buttons can be used to turn on the machine, turn off the machine, pair with Bluetooth, start the treatment program for treatment, increase the intensity or depth, and decrease the intensity or depth. Among them, the firmware run by the microprocessor is the intelligent control center of the entire electrical regulation host. The firmware contains multiple core treatment programs, an electrical regulation basic impedance reduction formula, and function control and implementation algorithm logics. The core treatment programs are composed of several electrical regulation basic treatment formulas with different targeting effects. Among them, the electrical regulation basic treatment formulas include a peripheral mechanism formula, an extra-segmental mechanism formula, a neurotransmitter promotion formula, a blood circulation promotion formula, a relaxation formula, and a muscle strengthening formula, etc. The peripheral mechanism formula targets the regulation of peripheral nerves. Through specially designed electrical regulation signals, it weakens pain signals and blocks the transmission of pain signals to the central nervous system to achieve analgesia. The extra-segmental mechanism formula uses specially designed electrical regulation signals to induce somatic sensory A-δ activity, activate the descending pain inhibitory pathway, and inhibit the descending pain promotion pathway to produce analgesia for several hours. The neurotransmitter promotion formula uses specially designed electrical regulation signals to transmit stimuli to the central nervous system through sensory nerves to promote the release of neurotransmitters such as serotonin, acetylcholine, norepinephrine, GABA, and endorphins to achieve continuous anti-inflammatory and analgesic effects. The blood circulation promotion formula uses specially designed electrical regulation signals to stimulate motor nerves to drive the expansion and contraction of muscles to promote the rapid flow of blood and accelerate recovery. The relaxation formula uses specially designed electrical regulation signals to stimulate motor nerves to drive the movement of muscles and joints to release the tension and pressure therein to achieve rehabilitation and analgesic effects. The muscle strengthening formula uses specially designed electrical regulation signals to stimulate motor nerves to drive muscles to perform strength and endurance simulation exercises to enhance muscle strength and endurance and promote muscle growth at the same time. The basic impedance reduction formula uses specially designed electrical regulation signals to temporarily damage the high-impedance tissue on the skin surface, especially the stratum corneum, and rapidly polarize the subcutaneous tissue, so that each electrical regulation basic treatment formula and drug formula of the core treatment program can quickly pass through and penetrate deeply. Among them, the construction of each basic formula is achieved by our specially constructed AI-targeted neural network small model learning and training on the experimental data developed over the years and the experimental data of previous studies, and finally determining the optimal electrical regulation parameters of each basic formula, such as pulse frequency, pulse width, pulse phase, pulse group width, amplitude, action time, etc.Among them, through the machine learning of skin impedance and microelectric field data by the small AI-targeted neural network model, as well as the testing and verification of multiple in vitro and in vivo tissues, the selected impedance reduction formula parameters are a pulse frequency of about 1-5 kHz, a pulse width of 1-5 μs, a group wave frequency of 2-50 Hz, and a regulation mode with optional intensity or depth. With the cooperation of this impedance reduction formula, the depth of the therapeutic effect can reach 6-8 cm. Among them, each core treatment program is constructed by selecting different formulas according to its different therapeutic effects. For example, for the treatment of pain caused by muscle stiffness, a 5-minute relaxation formula will be used first, then a 5-minute segmental external mechanism formula, then a 5-minute blood circulation promotion formula, and finally a neurochemical substance promotion formula to achieve continuous analgesia. All core treatment programs are classified into three categories: analgesia, strengthening, and relaxation according to their targeted effects, treatment purposes, and levels. The analgesia category contains core treatment programs such as general analgesia, acute analgesia, chronic analgesia, primary pain relief, intermediate pain relief, advanced pain relief, neuropathic pain analgesia, anti-inflammatory analgesia, etc.; the strengthening category contains core treatment programs such as strength enhancement, endurance increase, explosive power improvement, primary strengthening, intermediate strengthening, advanced strengthening, etc.; the relaxation category contains core treatment programs such as primary relaxation, intermediate relaxation, advanced relaxation, deep relaxation, etc. The following table is an example of the core treatment program composed of each electroregulation-based treatment formula:.

[0026] Such as Figure 3, the App TinyAI optimization module includes key units such as human-computer interaction, prescription optimization unit, TinyML small model machine learning, QOLSP efficacy evaluation, cloud platform interaction, electrical regulation host interaction unit, local database, BLE Bluetooth control, etc. Among them, the human-computer interaction unit enables the pain symptom data input by the user before the start of treatment to be learned, cleaned, regularized, classified, and analyzed by the TinyML small model machine unit. The TinyAI prescription optimization unit combines the electrical regulation targeted treatment effect data and the drug targeted treatment effect data for optimal intelligent matching to ensure that the treatment procedures and drugs for the collaborative treatment obtained have similar or complementary targeted treatment effects. Finally, a personalized treatment course prescription containing several optimal treatment procedures, usage methods, and treatment cycles is generated according to the symptoms and presented to the user for treatment according to the prescription. Among them, the QOLSP efficacy evaluation unit periodically visits the treatment progress and feedback of the user according to the QOLSP (Pain Quality of Life Scale) that combines VAR (Visual Analogue Scale) and PGIC (Overall Impression of Change), stores these data of all users, performs background big data machine learning and efficacy evaluation, forms index tables such as gender group, age group, disease, efficacy score, treatment course, adjustment times, adjustment history, treatment procedure group, drugs, etc., and continuously updates them, so that the search engine of the App TinyAI optimization module can quickly obtain the data required in the treatment course optimization algorithm decision. When necessary, the App TinyAI optimization module will adjust and optimize the treatment course and treatment procedures for the user, and at the same time synchronize data with the cloud service platform. Among them, through the machine learning of the final personalized optimized treatment course prescription data corresponding to different diseases of all patients, the optimal collaborative treatment drugs are found, the collaborative treatment and efficacy are continuously optimized, and at the same time data is synchronized with the cloud service platform. Among them, the App TinyAI optimization module (300) synchronizes the data and analysis results collected from the client, which have been cleaned, filtered, and regularized in real time, to the cloud service platform. The cloud platform AI then performs big data learning and training on all user data using BigML and regularly updates the new parameters and models obtained from the training to the TinyAI on the client, so that the optimization operation of the TinyAI on the client always has the support of big data.

[0027] Such as Figure 1 , Figure 2 and Figure 3, wherein, before the user starts the treatment, the nerve electroregulation host needs to be connected to the composite electrode patch first. An appropriate amount of plaster or liquid medicine is placed on the drug loading layer, and then the composite electrode patch is placed on the treatment site. When the user follows the treatment course prescription issued by the App TinyAI optimization module and selects a treatment program to start the treatment, the nerve electroregulation host will first drive the detection circuit to detect whether the composite electrode patch is in good contact with the skin and prompt the user through the flashing or color change of the LED light. Only when the contact is good can the treatment be started. After the user starts the treatment, the firmware of the nerve electroregulation host will drive the hardware to continuously output the corresponding electroregulation impedance reduction mode according to the basic impedance reduction formula to significantly reduce the impedance of the cortex and subcutaneous tissues. At the same time, it will drive the hardware to output the corresponding electroregulation treatment mode according to the basic treatment formula in the treatment program. Under the drive of the electroregulation treatment formula and the current, the drug molecules can quickly reach the target site of the deep lesion for synergistic treatment. When the user's treatment starts normally, in addition to using the "-" and "+" buttons to control the intensity and depth of the treatment, the entire treatment process will be automatically controlled and completed by the firmware of the nerve electroregulation host without further operation. The intelligent nerve electroregulation and drug synergistic treatment system and control method enable most of the complex work to be completed by TinyAI, with simple human-computer interaction of the nerve electroregulation host, simple treatment operation, and a significant reduction in production and product costs.

[0028] For the intelligent nerve electroregulation and drug synergistic treatment system and control method, the clinical experiments of the synergistic treatment system with our self-developed traditional Chinese medicine Zheng Gu Shui and the Western medicine Voltaren on the market in several patients have proved that the improvement rate of the QOLSP (VAS + PGIC) score of the system is 42% higher than that of the single drug treatment method, and there are no skin adverse reactions.

[0029] In the embodiments provided by the present invention, it should be understood that the disclosed system and method can be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the division of the modules is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed coupling or direct coupling or communication connection between each other can be through some interfaces. The indirect coupling or communication connection of the device or unit can be in electrical, mechanical or other forms.

[0030] The unit described as a separation component may or may not be physically separated. The component shown as a unit may or may not be a physical unit, that is, it may be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0031] In addition, each functional unit in various embodiments of the present invention may be integrated into a processing unit, may be physically present separately for each unit, or two or more units may be integrated into one unit. The above-mentioned integrated unit can be implemented in the form of hardware or in the form of a hardware plus software functional unit.

[0032] The above-mentioned integrated unit implemented in the form of a software functional unit can be stored in a computer-readable storage medium. The above-mentioned software functional unit stored in a storage medium includes several instructions to enable a computer device (which may be a personal computer, a server, or a network device, etc.) or a processor to execute some steps of the methods described in various embodiments of the present invention. The foregoing storage medium includes: various media such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk, or an optical disc that can store program codes.

[0033] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of various embodiments of the present invention.

Claims

1. An intelligent neural electroregulation and drug synergistic therapy system, comprising: Composite electrode patch, nerve electroregulation host and App TinyAI optimization module; characterized in that the composite electrode patch is composed of a conductive hydrogel layer, a conductive film, a drug loading layer, a peelable double-sided adhesive, an electrode connection button and an integrated substrate; the nerve electroregulation host includes a plurality of core treatment programs composed of several electroregulation basic treatment formulas with different targeting effects and an electroregulation basic impedance reduction formula; the App TinyAI optimization module automatically optimizes the symptomatic treatment based on the patient's specific pain data, electroregulation targeting data and drug targeting data to generate a personalized treatment course prescription, and continuously adjusts and optimizes the treatment course prescription through intelligent machine learning of periodic efficacy follow-up data.

2. The intelligent neural electroregulation and drug synergistic treatment system according to claim 1, wherein When each core treatment program is used, it is superimposed with the basic impedance reduction formula, and under the continuous action of the basic impedance reduction formula, the impedance of the cortex and subcutaneous tissue is greatly reduced, so that the electroregulation basic treatment formula and drug molecules can be quickly driven by the current to reach the target of the deep lesion for synergistic treatment.

3. The co-treatment according to claim 2, wherein The core treatment programs and drugs for synergistic treatment have similar or complementary targeted treatment effects.

4. The composite electrode patch according to claim 1, wherein, The drug loading layer can load plaster or liquid medicine without loss. The loading layer can be a general conductive material, or a non-conductive material can be used for conductive drugs. The loading layer can be peeled and replaced.

5. The nerve electroregulation mainframe according to claim 1, characterized in that, Each treatment program is composed of a core treatment program and a basic impedance reduction formula, and the core treatment program is composed of several electroregulation basic treatment formulas with different targeting effects.

6. The electro-regulated basic treatment formula according to claim 5, characterized in that, The peripheral mechanism formula targets the regulation of peripheral nerves and achieves analgesia by weakening pain signals and blocking the transmission of pain signals to the central nervous system.

7. The electroregulated basic treatment formula according to claim 5, characterized in that, The extra-segmental mechanism formula induces somatic sensory A-δ activity, activates the descending pain inhibitory pathway, and inhibits the descending pain promoting pathway to produce analgesia for several hours.

8. The electroregulated basic treatment formula according to claim 5, characterized in that, The nerve chemical substance promotion formula promotes the release of nerve chemical substances mediated by special stimulation signals transmitted from sensory nerves to the central nervous system, such as serotonin, acetylcholine, norepinephrine, GABA and endorphins, to achieve continuous anti-inflammatory and analgesic effects.

9. The electro-regulated basic treatment formula according to claim 5, wherein The blood circulation promotion formula stimulates the movement of muscles driven by motor nerves to promote the rapid flow of blood to accelerate recovery.

10. The electroregulated basic treatment formula according to claim 5, characterized in that, The relaxation formula stimulates the movement of muscles and joints driven by motor nerves to release the pressure therein to achieve rehabilitation and analgesic effects.

11. The electroregulated basic treatment formula according to claim 5, wherein, The muscle strengthening formula stimulates the movement of muscles driven by motor nerves to perform simulated strength and endurance exercises to enhance the strength and endurance of muscles, and at the same time promote muscle growth.

12. The basic impedance-reducing formulation according to claim 4, wherein, By temporarily damaging the high-impedance tissue on the skin surface, especially the stratum corneum, and rapidly polarizing the subcutaneous tissue, each electroregulation basic treatment formula and drug formula of the core treatment program can quickly pass through and penetrate deeply.

13. A control method for an intelligent neural electroregulation and drug synergistic treatment system, characterized in that, The App TinyAI optimization module described in claim 1 allows the user to input pain data before starting treatment and perform machine learning, and combines electroregulation targeted treatment data and drug targeted treatment data for optimal intelligent matching to prescribe the right medicine and generate a personalized treatment course prescription, which includes several treatment programs, usage methods and treatment cycles.

14. The control method of the intelligent neural electroregulation and drug synergistic treatment system according to claim 13, characterized in that, Before the user starts the treatment, the nerve electroregulation host needs to be connected to the composite electrode patch first. An appropriate amount of plaster or liquid medicine is placed on the drug loading layer, and then the composite electrode patch is placed on the treatment site.

15. The control method of the intelligent neural electroregulation and drug synergistic treatment system according to claim 13, characterized in that, When the user follows the treatment course prescription issued by the App TinyAI optimization module and selects a treatment program to start the treatment, the nerve electroregulation host will first detect whether the composite electrode patch is in good contact with the skin and prompt the user with the flashing or color change of the LED light. Only when the contact is good can the treatment be started.

16. The control method of the intelligent neural electroregulation and drug synergistic treatment system according to claim 13, characterized in that, After the user starts the treatment, the firmware of the nerve electroregulation host will drive the hardware to continuously output the corresponding electroregulation impedance reduction mode according to the basic impedance reduction formula to reduce the impedance of the cortex and subcutaneous tissues. At the same time, it will drive the hardware to output the corresponding electroregulation treatment mode according to the basic treatment formula in the core treatment program and cooperate with the drug for treatment.

17. The control method of the intelligent neural electroregulation and drug synergistic therapy system according to claim 13, characterized in that, The App TinyAI optimization module periodically visits the treatment progress and feedback of users according to the QOLSP (Quality of Life in Pain Scale) that synthesizes VAR (Visual Analogue Scale) and PGIC (Patient Global Impression of Change), stores all these data of users, conducts big data machine learning and efficacy evaluation in the background, and forms index tables such as gender group, age group, disease, efficacy score, treatment course, number of adjustments, adjustment history, treatment program group, drugs, etc., and continuously updates them, so that the search engine of the App TinyAI optimization module can quickly obtain the data required in the treatment course optimization algorithm decision. When necessary, the App TinyAI optimization module will adjust and optimize the treatment course and treatment program for the user.

18. The control method of the intelligent neural electroregulation and drug synergistic treatment system according to claim 13, wherein, Through the machine learning of the final personalized optimized treatment course prescription data corresponding to different diseases of all patients, the optimal synergistic treatment drug is found, and the synergistic treatment and efficacy are continuously optimized.

19. The control method of the intelligent neural electroregulation and drug synergistic treatment system according to claim 13, wherein The App TinyAI optimization module (300) synchronizes the data and analysis results collected from the client, which have been cleaned, filtered, and regularized, to the cloud service platform in real time. The cloud platform AI conducts big data learning and training on all user data using BigML and periodically updates the new parameters and models obtained from the training to the TinyAI on the client, so that the optimization operation of the TinyAI on the client always has the support of big data.

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