Histamine removal and extraction equipment and method for kanamycin monosulfate

Abstract

The invention relates to the technical field of histamine removal of kanamycin monosulfate, in particular to histamine removal and extraction equipment and method for kanamycin monosulfate, the equipment comprises an extraction cylinder and an end cylinder, the end cylinder is mounted at the lower end of the extraction cylinder, and a stirring structure capable of rotating through power is coaxially arranged in the extraction cylinder; a pressing disc is slidably inserted into the extraction barrel, a bottom tray is slidably inserted into the lower end of the extraction barrel, a liquid disc is arranged on the lower side of the bottom tray, and the upper end of the liquid disc is communicated with a liquid permeable end rod. According to the device, the liquid-permeable hose is spirally inserted between residues, meanwhile, the liquid-permeable part of the liquid-permeable end rod is inserted into the residues, liquid in the residues flows out through the liquid-permeable hose inserted between the residues and the liquid-permeable end rod, the stirring structure and the liquid-permeable hose rotate again, the compacted residues are scattered, and the residues are stirred to be uniform. Residues in contact with the liquid-permeable hose and the liquid-permeable end rod are changed, so that liquid residues in the residues can be reduced during reciprocating compaction of the pressure plate.

Description

Technical Field

[0001] The present invention relates to the technical field of histamine removal of kanamycin monosulfate, and particularly relates to an apparatus and method for histamine removal and extraction of kanamycin monosulfate. Background Art

[0002] The method for histamine removal and extraction of kanamycin monosulfate needs to be optimized in combination with its physical and chemical properties and production process. Histamine is easily soluble in ethanol solution, so ethanol can be used as an extractant. The operation process generally includes steps such as mother liquor pretreatment, ethanol extraction, adsorption and decolorization, crystallization purification, and centrifugal drying.

[0003] There are raw material residues in the mother liquor, and after ethanol extraction, it is necessary to separate the raw material residues from the liquid. In the prior art, the mixed liquid is placed on the upper side of the filter screen, and the filter screen blocks the residues in the mixed liquid. In order to reduce the liquid remaining in the residues, pressure is also applied to the residues. However, when the residues are thick, the liquid extruded by the pressure cannot be fully separated from the residues. For this reason, an apparatus and method for histamine removal and extraction of kanamycin monosulfate are proposed. Summary of the Invention

[0004] In order to fully separate the liquid in the compacted residues, the present invention provides an apparatus and method for histamine removal and extraction of kanamycin monosulfate.

[0005] An apparatus for histamine removal and extraction of kanamycin monosulfate provided by the present invention adopts the following technical solution: It includes an extraction cylinder and an end cylinder. The end cylinder is installed at the lower end of the extraction cylinder. A stirrer structure that can rotate by power is coaxially arranged inside the extraction cylinder. A pressure plate is slidably inserted inside the extraction cylinder, and the pressure plate is coaxially connected to the stirrer structure.

[0006] A bottom tray is slidably inserted inside the lower end of the extraction cylinder. A liquid tray is arranged below the bottom tray. A liquid-permeable end rod is connected and installed at the upper end of the liquid tray. The bottom tray is slidably sleeved on the outer surface of the liquid-permeable end rod. A power control structure for controlling the up and down movement of the bottom tray and the liquid tray is installed outside the extraction cylinder.

[0007] A liquid-permeable hose is fixed to the bottom surface of the pressure plate. A concave ring is fixed to the lower end of the liquid-permeable hose. The concave ring is rotatably inserted on the upper surface of the bottom tray. A bent liquid-permeable rod is slidably inserted below the concave ring on the bottom surface of the bottom tray. The other end of the bent liquid-permeable rod is connected and installed to communicate with the liquid tray. An electric telescopic rod A for controlling the up and down movement of the stirrer structure is installed on the outer surface of the end cylinder. A telescopic liquid discharge pipe is fixedly connected to the lower end of the liquid tray, and the other end of the telescopic liquid discharge pipe penetrates through the inner wall of the end cylinder.

[0008] Optionally, the stirrer structure includes a shaft rod and a telescopic stirrer rod. The upper end of the telescopic stirrer rod is elastically and rotatably connected to a slider. A vertical groove that is vertically penetrated and matched with the slider is opened on the end face of the shaft rod. The slider is slidably inserted and matched inside the vertical groove. The pressure plate is coaxially fixedly sleeved on the outer surface of the shaft rod.

[0009] A bent rod is arranged on the upper side of the shaft rod. One end of the bent rod is fixed to the upper end of the extraction cylinder, and the other end of the bent rod is rotatably connected with an end plate. The end plate is elastically connected to the shaft rod. The end plate, the shaft rod and the extraction cylinder are coaxial. A vertical rod is fixed to the upper end of the slider, the upper end of the vertical rod is fixed to the bent rod, and the upper end of the vertical rod is fixed to the end plate.

[0010] The bent rod is provided with a power rotating structure for controlling the rotation of the shaft rod, and the upper end of the electric telescopic rod A is rotatably sleeved on the outer surface of the shaft rod.

[0011] Optionally, the lower end of the telescopic stirring rod is a large end, and the large end of the telescopic stirring rod is adapted to the shape of the vertical groove.

[0012] Optionally, the power rotating structure includes a motor and a long tooth column. A gear is coaxially fixed on the outer surface of the shaft rod, the gear meshes with the long tooth column, the long tooth column is coaxially fixed and sleeved on the output end of the motor, and the distance between the upper end surface of the gear and the bottom surface of the long tooth column is equal to half of the distance between the bottom surface of the pressure plate and the upper surface of the bottom tray.

[0013] Optionally, the liquid permeable hose is arranged in a conical spiral shape. The circumferential side surface of the bent liquid permeable rod and the circumferential side surface of the liquid permeable end rod at one end located inside the bottom tray are liquid permeable, and the liquid permeable hose is liquid permeable.

[0014] Optionally, a convex rod is arranged on the upper side of one end of the telescopic stirring rod located below the shaft rod, and the convex rod is elastically slidably inserted into the bottom surface of the shaft rod.

[0015] Optionally, the power control structure includes an electric telescopic rod B and a linkage ring. The extraction cylinder is coaxially located on the inner ring side of the linkage ring. A linkage rod is fixed to the bottom surface of the linkage ring, the other end of the linkage rod is fixed to the bottom surface of the bottom tray, and the end cylinder is slidably sleeved on the outer surface of the linkage rod.

[0016] A transmission rod is fixed to the bottom surface of the liquid tray, the other end of the transmission rod slidably penetrates through the inner wall of the end cylinder, the upper end of the electric telescopic rod B is fixed to the end cylinder, and a bent plate is fixed to the lower end of the electric telescopic rod B.

[0017] A triangular insertion block is horizontally installed at one end of the transmission rod located outside the end cylinder. The other side of the triangular insertion block meshes with a groove plate. A bent elastic telescopic rod is fixed to the upper end surface of the groove plate, the upper end of the bent elastic telescopic rod is fixed to the outer ring surface of the linkage ring, the upper end of the bent elastic telescopic rod is a horizontal telescopic end, and a vertical elastic telescopic rod is fixed to the bottom surface of the horizontal end of the bent elastic telescopic rod. The lower end of the vertical elastic telescopic rod is fixed to the transmission rod.

[0018] Optionally, a plurality of long grooves are formed in the surface of the groove plate close to the end cylinder. The upper surface of the triangular insertion block is inclined, and an elastic lifting plate is arranged below the transmission rod. The elastic lifting plate is fixed to the bent plate.

[0019] The upper end of the bent plate bends away from the end cylinder, and an elastic push plate is elastically rotatably connected to the bottom surface of the end of the bent plate that bends away from the end cylinder. The elastic push plate is located inside one of the long grooves, and the end of the elastic push plate away from the end cylinder is located below the other end.

[0020] A support rod is fixed to the outer side of the end cylinder near the groove plate surface. The other end of the support rod is located inside one of the long grooves, and the bottom surface of the end of the support rod located inside the long groove is an inclined surface.

[0021] Optionally, the concave ring is coaxially arranged with the bottom tray, and the bottom surface of the concave ring is open.

[0022] The usage method of the histamine removal extraction device for kanamycin monosulfate includes the following steps: S1. Put the mother liquor and the ethanol extractant into the extraction cylinder, and the stirring structure rotates to increase the mixing effect of the ethanol extractant and the mother liquor.

[0023] S2. After the extraction is completed, control the liquid tray to move upward relative to the bottom tray, move the liquid-permeating part of the liquid-permeating end rod to the upper side of the bottom tray, and at the same time move the liquid-permeating part of the bent liquid-permeating rod into the concave ring.

[0024] The liquid in the extraction cylinder flows into the liquid-permeating hose and the liquid-permeating end rod. The liquid in the liquid-permeating hose flows into the concave ring, flows to the liquid tray through the liquid-permeating part of the bent liquid-permeating rod, and the liquid in the liquid-permeating end rod flows into the liquid tray.

[0025] S4. In order to reduce the liquid residue inside the residue, the electric telescopic rod A controls the pressing plate to move downward to apply pressure to the residue. When the pressing plate applies pressure, the liquid-permeating hose is spirally inserted between the residues, and at the same time the liquid-permeating part of the liquid-permeating end rod is inserted into the residue.

[0026] S5. When the pressing plate applies pressure, the liquid in the residue flows out through the liquid-permeating hose and the liquid-permeating end rod inserted between the residues, preventing the liquid from flowing out fully when the residue is thick.

[0027] S6. After driving the pressing plate to move upward, the shaft rod drives the liquid-permeating hose and the telescopic stirring rod to rotate again to disperse the compacted residue. Then when compacting again, change the residues contacted by the liquid-permeating hose and the liquid-permeating end rod, so that during the reciprocating compaction of the pressing plate, the liquid residue inside the residue can be reduced.

[0028] S7. Control the bottom tray to move downward and separate from the extraction cylinder, so that the residue on the upper side of the bottom tray can fall into the end cylinder, and the liquid in the liquid tray is discharged from the telescopic liquid discharge pipe.

[0029] S8. Add n-pentanol, shake and extract. Combine the filtrates. Take the n-pentanol extract in a separatory funnel and extract it with hydrochloric acid 3 times. Combine the hydrochloric acid extracts and dilute to volume with hydrochloric acid solution. Then add sodium carbonate solution and azo reagent, mix well with water, add saturated borax solution, stir evenly, add zinc acetate solution, stir, and then take the supernatant and centrifuge it in a centrifuge. Take the supernatant after centrifugation and filter it through a 0.22 μm filter membrane to obtain the finished histamine solution.

[0030] In summary, the present invention includes the following beneficial technical effects: 1. By providing components such as a liquid-permeating hose, a bent liquid-permeating rod, a concave ring, and a liquid-permeating end rod, the present invention controls the liquid tray to move upward close to the bottom tray through a power control structure, so that the liquid-permeating part of the liquid-permeating end rod moves to the upper side of the bottom tray, and at the same time drives the liquid-permeating part of the bent liquid-permeating rod to move into the concave ring. The electric telescopic rod A controls the pressing plate to move downward to apply pressure to the residue. When the pressing plate applies pressure, the liquid-permeating hose is spirally inserted between the residues, and at the same time the liquid-permeating part of the liquid-permeating end rod is inserted into the residue. When the pressing plate applies pressure, the liquid in the residue flows out through the liquid-permeating hose and the liquid-permeating end rod inserted between the residues. After driving the pressing plate to move upward, the stirring structure and the liquid-permeating hose are rotated again to disperse the compacted residue. Then when compacting again, the residues contacted by the liquid-permeating hose and the liquid-permeating end rod are changed, so that during the reciprocating compaction of the pressing plate, the residual liquid inside the residue can be reduced.

[0031] 2. By providing components such as a telescopic stirring rod, a slider, and a vertical rod, the bent rod fixes the slider through an end plate and a vertical rod. When the shaft rod moves downward, the slider slides in the vertical groove, and the telescopic stirring rod gradually enters the vertical groove following the slider, so that the telescopic stirring rod retracts into the vertical groove, and the angle of the telescopic stirring rod relative to the shaft rod is continuously changed during the downward movement of the shaft rod, so that the telescopic stirring rod can stir the mixed liquid within a variety of ranges.

[0032] 3. By providing components such as an elastic lifting plate, an elastic pushing plate, a support rod, and a groove plate, the support rod is inserted into the long groove of the groove plate. When the electric telescopic rod B pulls the bent plate to drive the elastic lifting plate and the elastic pushing plate to move upward, the elastic pushing plate elastically rotates continuously when moving in different long grooves. At the same time, when the elastic lifting plate moves upward, it pushes the transmission rod upward to drive the liquid tray to move upward, so that the liquid-permeating end of the liquid-permeating end rod moves to the upper side of the bottom tray, and the triangular plug is inserted into the long groove to support the liquid tray, and the mixed liquid on the upper side of the bottom tray can be filtered. When it is necessary to discharge the residue, the electric telescopic rod B controls the bent plate to move downward. When the elastic pushing plate moves downward, the lower end of the elastic pushing plate is stuck in the long groove, so that the elastic pushing plate gradually rotates to the horizontal end. When the elastic pushing plate rotates, it gradually pushes the groove plate away from the end cylinder, so that the support rod is separated from the groove plate. Then when the elastic pushing plate continues to move downward, it drives the bottom tray to move downward, so that the residue in the extraction cylinder can be discharged from the lower end of the extraction cylinder. Description of the Drawings

[0033] Figure 1 is a schematic diagram of the overall structure in an embodiment of the present invention; Figure 2 is a schematic diagram of the connection structure between the extraction cylinder and the end cylinder in an embodiment of the present invention; Figure 3 is a schematic diagram of the connection structure between the elastic push plate and the bent plate in an embodiment of the present invention; Figure 4 is a schematic side view of a partial structure in an embodiment of the present invention; Figure 5 is a schematic diagram of the connection structure between the concave ring and the bottom tray in an embodiment of the present invention; Figure 6 is a schematic front view of a partial structure in an embodiment of the present invention; Figure 7 is a schematic diagram of the connection structure between the bottom tray and the liquid-permeable end rod in an embodiment of the present invention; Figure 8 is a schematic diagram of the connection structure between the gear and the long tooth column in an embodiment of the present invention; Figure 9 is a schematic diagram of the connection structure between the slider and the telescopic stirring rod in an embodiment of the present invention.

[0034] Reference numerals: 1, extraction cylinder; 2, end cylinder; 3, pressure plate; 4, stirring structure; 41, shaft rod; 42, telescopic stirring rod; 421, convex rod; 43, slider; 44, vertical groove; 45, bent rod; 46, end plate; 47, vertical rod; 48, power rotation structure; 481, motor; 482, long tooth column; 483, gear; 5, bottom tray; 6, liquid tray; 7, power control structure; 71, electric telescopic rod B; 72, linkage ring; 73, linkage rod; 74, transmission rod; 75, bent plate; 76, triangular insert block; 77, groove plate; 78, bent elastic telescopic rod; 79, vertical elastic telescopic rod; 710, elastic lifting plate; 711, long groove; 712, elastic push plate; 713, support rod; 8, liquid-permeable end rod; 9, liquid-permeable hose; 10, concave ring; 11, bent liquid-permeable rod; 12, telescopic liquid outlet pipe; 13, electric telescopic rod A. Detailed implementation manners

[0035] The following will further elaborate on the present invention in conjunction with the attached Figures 1-9 drawings.

[0036] An embodiment of the present invention discloses a histamine removal extraction device for kanamycin monosulfate. As Figures 1-9 shown, it includes an extraction cylinder 1 and an end cylinder 2. The end cylinder 2 is installed at the lower end of the extraction cylinder 1. Inside the extraction cylinder 1, a stirrer structure 4 that can be driven to rotate coaxially is provided. A pressure plate 3 is slidably inserted inside the extraction cylinder 1, and the pressure plate 3 is coaxially connected to the stirrer structure 4.

[0037] The stirring structure 4 includes a shaft 41 and a telescopic stirring rod 42. The telescopic stirring rod 42 has a tendency to stretch out due to its own elasticity. The upper end of the telescopic stirring rod 42 is elastically rotatably connected to a slider 43. The elastic connection between the slider 43 and the telescopic stirring rod 42 has a tendency to make the telescopic stirring rod 42 in an inclined setting. The telescopic stirring rod 42 and the slider 43 are connected by a torsion spring. The end surface of the shaft 41 is provided with a vertical groove 44 that cooperates with the slider 43 and passes through the vertical groove 44. The slider 43 cooperates with the vertical groove 44 to slide and insert in the vertical groove 44. 4, the telescopic stirring rod 42 is located at the upper side of one end of the lower side of the shaft rod 41 and is provided with a protruding rod 421, which is elastically slidably inserted into the bottom surface of the shaft rod 41. After the telescopic stirring rod 42 moves out of the vertical groove 44, the telescopic stirring rod 42 contacts the protruding rod 421 under the elastic connection with the slider 43, which limits the maximum angle of the telescopic stirring rod 42. The pressure plate 3 is coaxially fixedly sleeved on the outer surface of the shaft rod 41, and the lower end of the telescopic stirring rod 42 is a large end, which is adapted to the shape of the vertical groove 44.

[0038] A bent rod 45 is provided on the upper side of the shaft rod 41, one end of the bent rod 45 is fixed to the upper end of the extraction cylinder 1, and the other end of the bent rod 45 is rotatably connected to an end plate 46, which is elastically connected to the shaft rod 41. The elastic connection between the end plate 46 and the shaft rod 41 has a tendency to pull the end plate 46 close to the shaft rod 41, and the end plate 46, the shaft rod 41 and the extraction cylinder 1 are coaxial. A vertical rod 47 is fixed to the upper end of the slider 43, and the upper end of the vertical rod 47 is fixed to the bent rod 45, and the upper end of the vertical rod 47 is fixed to the end plate 46. When the shaft rod 41 moves downward, the slider 43 gradually drives the telescopic stirring rod 42 to rotate and shrink into the vertical groove 44. When the pressure plate 3 moves downward, the large end of the telescopic stirring rod 42 enters the vertical groove 44 to cooperate with the vertical groove 44 to block the vertical groove 44.

[0039] An electric telescopic rod A13 for controlling the up and down movement of the stirring structure 4 is installed on the outer surface of the end tube 2.

[0040] The bent rod 45 is equipped with a power rotating structure 48 for controlling the rotation of the shaft rod 41 , and the upper end of the electric telescopic rod A13 is rotatably sleeved on the outer surface of the shaft rod 41 .

[0041] The power rotating structure 48 includes an electric motor 481 and a long tooth column 482. A gear 483 is coaxially fixed to the outer surface of the shaft 41. The gear 483 meshes with the long tooth column 482. The long tooth column 482 is coaxially fixed and sleeved on the output end of the motor 481. The distance between the upper end surface of the gear 483 and the bottom surface of the long tooth column 482 is equal to half the distance between the bottom surface of the pressure plate 3 and the upper surface of the bottom tray 5. When the gear 483 meshes with the long tooth column 482, the motor 481 can drive the shaft 41 to rotate through the meshing of the long tooth column 482 and the gear 483. When the shaft 41 rotates, it drives the telescopic stirring rod 42 to rotate to stir the mixed liquid. After the shaft 41 drives the gear 483 to move downward and disengage from the long tooth column 482, the shaft 41 stops rotating, so that the pressure plate 3 moves downward to apply a stable pressure to the residue on the lower side.

[0042] A bottom tray 5 is slidably inserted inside the lower end of the extraction cylinder 1. A liquid tray 6 is arranged on the lower side of the bottom tray 5. A liquid-permeable end rod 8 is connected and installed at the upper end of the liquid tray 6. The bottom tray 5 is slidably sleeved on the outer surface of the liquid-permeable end rod 8.

[0043] A power control structure 7 for controlling the up and down movement of the bottom tray 5 and the liquid tray 6 is installed outside the extraction cylinder 1.

[0044] The power control structure 7 includes an electric telescopic rod B71 and a linkage ring 72. The extraction cylinder 1 is coaxially located inside the inner ring side of the linkage ring 72. A linkage rod 73 is fixed to the bottom surface of the linkage ring 72. The other end of the linkage rod 73 is fixed to the bottom surface of the bottom tray 5. The end cylinder 2 is slidably sleeved on the outer surface of the linkage rod 73.

[0045] A transmission rod 74 is fixed to the bottom surface of the liquid tray 6. The other end of the transmission rod 74 slidably penetrates through the inner wall of the end cylinder 2. The upper end of the electric telescopic rod B71 is fixed to the end cylinder 2. A bent plate 75 is fixed to the lower end of the electric telescopic rod B71. The electric telescopic rod B71 can drive the bent plate 75 to move up and down.

[0046] A liquid-permeable flexible hose 9 is fixed to the bottom surface of the pressing disc 3. A concave ring 10 is fixed to the lower end of the liquid-permeable flexible hose 9. The concave ring 10 is rotationally inserted on the upper surface of the bottom tray 5. A bent liquid-permeable rod 11 is slidably inserted on the lower side of the bottom surface of the bottom tray 5 and below the concave ring 10. The concave ring 10 and the bottom tray 5 are coaxially arranged. The bottom surface of the concave ring 10 is open. The other end of the bent liquid-permeable rod 11 is connected and installed with the liquid tray 6.

[0047] A triangular insertion block 76 is horizontally installed at one end of the transmission rod 74 outside the end cylinder 2. The other side of the triangular insertion block 76 is engaged with a groove plate 77. A plurality of long grooves 711 are formed on the surface of the groove plate 77 close to the end cylinder 2. The upper surface of the triangular insertion block 76 is inclined. An elastic lifting plate 710 is arranged on the lower side of the transmission rod 74. The elastic lifting plate 710 is fixed to the bent plate 75. When the elastic lifting plate 710 moves upward, an upward thrust is applied to the transmission rod 74, and the liquid tray 6 can be pushed upward by the transmission rod 74.

[0048] A bent elastic telescopic rod 78 is fixed to the upper end surface of the groove plate 77. The upper end of the bent elastic telescopic rod 78 is fixed to the outer ring surface of the linkage ring 72. The upper end of the bent elastic telescopic rod 78 is a horizontal telescopic end. The elasticity of the bent elastic telescopic rod 78 has a tendency to pull the groove plate 77 close to the end cylinder 2, so that the triangular insertion block 76 can cooperate with the long grooves 711 to limit the distance between the liquid tray 6 and the bottom tray 5. A vertical elastic telescopic rod 79 is fixed to the bottom surface of the horizontal end of the bent elastic telescopic rod 78. The lower end of the vertical elastic telescopic rod 79 is fixed to the transmission rod 74. The vertical elastic telescopic rod 79 has a tendency to push the transmission rod 74 away from the bent elastic telescopic rod 78.

[0049] The upper end of the bent plate 75 bends away from the side of the end cylinder 2. An elastic push plate 712 is elastically rotatably connected to the bottom surface of the end of the bent plate 75 that bends away from the end cylinder 2. The elastic push plate 712 is located inside one of the long grooves 711. One end of the elastic push plate 712 away from the end cylinder 2 is located below the other end. When the elastic push plate 712 moves upward, the elastic push plate 712 elastically rotates continuously when moving in different long grooves 711. When the elastic push plate 712 moves downward, the lower end of the elastic push plate 712 is stuck in the long groove 711, causing the elastic push plate 712 to gradually rotate to the horizontal end. During the rotation of the elastic push plate 712, the elastic push plate 712 gradually pushes the groove plate 77 away from the end cylinder 2.

[0050] A support rod 713 is fixed to the outer side of the end cylinder 2 near the side of the groove plate 77. The other end of the support rod 713 is located inside one of the long grooves 711. The bottom surface of the end of the support rod 713 located inside the long groove 711 is an inclined surface, and the upper surface of the support rod 713 is a horizontal end. When the support rod 713 cooperates with the long groove 711 on the surface of the groove plate 77, it can support the groove plate 77 and the bottom tray 5. After the elastic push plate 712 rotates to the horizontal state and pushes the groove plate 77 away from the end cylinder 2, the support rod 713 and the long groove 711 are disengaged from the cooperation, so that the bottom tray 5 can move downward, and the residue in the extraction cylinder 1 can enter the end cylinder 2.

[0051] The liquid-permeable hose 9 is arranged in a conical spiral. The material of the liquid-permeable hose 9 can produce elastic bending. The liquid-permeable hose 9 will not collapse when pressed. The liquid-permeable hose 9 can allow liquid to pass through. The circumferential side surface of the bent liquid-permeable rod 11 and the circumferential side surface of the liquid-permeable end rod 8 at one end located inside the bottom tray 5 are arranged to be liquid-permeable, and the liquid-permeable hose 9 is arranged to be liquid-permeable.

[0052] During the upward movement of the liquid tray 6, the liquid-permeable part of the liquid-permeable end rod 8 can be driven to move to the upper side of the bottom tray 5. At the same time, the bent liquid-permeable rod 11 enters below the concave ring 10, so that the liquid entering the liquid-permeable hose 9 can enter the liquid tray 6 through the concave ring 10 and the bent liquid-permeable rod 11.

[0053] A telescopic liquid discharge pipe 12 is fixedly communicated with the lower end of the liquid tray 6. The liquid in the liquid tray 6 can be discharged through the outer end of the telescopic liquid discharge pipe 12 for the treatment of the next step. The other end of the telescopic liquid discharge pipe 12 penetrates through the inner wall of the end cylinder 2.

[0054] The usage method of the histamine removal extraction equipment for kanamycin monosulfate includes the following steps: S1. Put the mother liquor and the ethanol extractant into the extraction cylinder 1, and the stirring structure 4 rotates to increase the mixing effect of the ethanol extractant and the mother liquor; S2. After the extraction is completed, control the liquid tray 6 to move upward relative to the bottom tray 5, move the liquid-permeable part of the liquid-permeable end rod 8 to the upper side of the bottom tray 5, and at the same time move the liquid-permeable part of the bent liquid-permeable rod 11 into the concave ring 10.

[0055] S3. The liquid in the extraction cylinder 1 flows into the liquid-permeable hose 9 and the liquid-permeable end rod 8. The liquid in the liquid-permeable hose 9 flows into the concave ring 10 and then flows into the liquid tray 6 through the liquid-permeable part of the bent liquid-permeable rod 11. The liquid in the liquid-permeable end rod 8 flows into the liquid tray 6.

[0056] S4. To reduce the liquid residue inside the residue, the electric telescopic rod A13 controls the pressing plate 3 to move downward to apply pressure to the residue. When the pressing plate 3 applies pressure, the liquid-permeable hose 9 is spirally inserted between the residues, and at the same time, the liquid-permeable part of the liquid-permeable end rod 8 is inserted into the residue.

[0057] S5. When the pressing plate 3 applies pressure, the liquid in the residue flows out through the liquid-permeable hose 9 and the liquid-permeable end rod 8 inserted between the residues, preventing the liquid from not flowing out sufficiently when the residue is thick.

[0058] S6. After driving the pressing plate 3 to move upward, the shaft rod 41 drives the liquid-permeable hose 9 and the telescopic stirring rod 42 to rotate again to disperse the compacted residue. Then when compacting again, the residues contacted by the liquid-permeable hose 9 and the liquid-permeable end rod 8 are changed, so that the residual liquid inside the residue can be reduced during the reciprocating compaction of the pressing plate 3.

[0059] S7. Control the bottom tray 5 to move downward to separate from the extraction cylinder 1, so that the residue on the upper side of the bottom tray 5 can fall into the end cylinder 2, and the liquid in the liquid tray 6 is discharged from the telescopic liquid outlet pipe 12.

[0060] S8. Add n-pentanol, shake for extraction, combine the filtrates. Take the n-pentanol extract in a separating funnel and extract it with hydrochloric acid 3 times. Combine the hydrochloric acid extracts and make the volume constant with hydrochloric acid solution. Then add sodium carbonate solution, azo reagent, add water and mix well. Add saturated borax solution, stir evenly. Add zinc acetate solution, stir and then take the supernatant and centrifuge it in a centrifuge. Take the supernatant after centrifugation and filter it through a 0.22 μm filter membrane to obtain the finished product of histamine solution.

[0061] The working principle is as follows: Put the raw material mother liquor and the ethanol extractant into the extraction cylinder 1, and then the mixing structure 4 rotates to mix the mixed liquid. After the extraction is completed, the liquid tray 6 is controlled by the power control structure 7 to move upward close to the bottom tray 5, so that the liquid-permeating part of the liquid-permeating end rod 8 moves to the upper side of the bottom tray 5, and at the same time drives the liquid-permeating part of the bent liquid-permeating rod 11 to move into the concave ring 10. The liquid in the extraction cylinder 1 flows into the liquid-permeating hose 9 and the liquid-permeating end rod 8. The liquid in the liquid-permeating hose 9 flows into the concave ring 10 and flows to the liquid tray 6 through the liquid-permeating part of the bent liquid-permeating rod 11. The liquid in the liquid-permeating end rod 8 flows into the liquid tray 6. The electric telescopic rod A13 controls the pressing plate 3 to move downward to apply pressure to the residue. When the pressing plate 3 applies pressure, the liquid-permeating hose 9 is spirally inserted between the residues, and at the same time the liquid-permeating part of the liquid-permeating end rod 8 is inserted into the residue. When the pressing plate 3 applies pressure, the liquid in the residue flows out through the liquid-permeating hose 9 and the liquid-permeating end rod 8 inserted between the residues. After driving the pressing plate 3 to move upward, the mixing structure 4 and the liquid-permeating hose 9 are rotated again to disperse the compacted residue. Then when compacting again, the residues contacted by the liquid-permeating hose 9 and the liquid-permeating end rod 8 are changed, so that during the reciprocating compaction of the pressing plate 3, the residual liquid inside the residue can be reduced.

[0062] The above are all preferred embodiments of the present invention, and the protection scope of the present invention is not limited accordingly. Therefore, all equivalent changes made according to the structure, shape, and principle of the present invention should be covered within the protection scope of the present invention.

Claims

1. An extraction device for removing histamine from kanamycin monosulfate, comprising an extraction cylinder (1) and an end cylinder (2), the end cylinder (2) being installed at the lower end of the extraction cylinder (1), characterized in that: Inside the extraction cylinder (1), a stirrer structure (4) that can rotate by power is coaxially arranged. A pressing plate (3) is slidably inserted inside the extraction cylinder (1), and the pressing plate (3) is coaxially connected to the stirrer structure (4). At the lower end inside the extraction cylinder (1), a bottom tray (5) is slidably inserted. A liquid tray (6) is arranged below the bottom tray (5). A liquid-permeable end rod (8) is connected and installed at the upper end of the liquid tray (6). The bottom tray (5) is slidably sleeved on the outer surface of the liquid-permeable end rod (8). A power control structure (7) for controlling the up and down movement of the bottom tray (5) and the liquid tray (6) is installed on the outer side of the extraction cylinder (1). A liquid-permeable flexible hose (9) is fixed to the bottom surface of the pressing plate (3). A concave ring (10) is fixed to the lower end of the liquid-permeable flexible hose (9). The concave ring (10) is rotatably inserted on the upper surface of the bottom tray (5). A bent liquid-permeable rod (11) is slidably inserted on the bottom surface of the bottom tray (5) below the concave ring (10). The other end of the bent liquid-permeable rod (11) is connected and installed to the liquid tray (6). An electric telescopic rod A (13) for controlling the up and down movement of the stirrer structure (4) is installed on the outer surface of the end cylinder (2). A telescopic liquid outlet pipe (12) is fixedly connected to the lower end of the liquid tray (6), and the other end of the telescopic liquid outlet pipe (12) penetrates through the inner wall of the end cylinder (2).

2. The histamine removal and extraction device for kanamycin monosulfate according to claim 1, characterized in that: The stirrer structure (4) includes a shaft rod (41) and a telescopic stirring rod (42). The upper end of the telescopic stirring rod (42) is elastically rotatably connected to a slider (43). A vertical groove (44) that is vertically through and matches the slider (43) is opened on the end face of the shaft rod (41). The slider (43) is slidably inserted and matched inside the vertical groove (44). The pressing plate (3) is coaxially fixedly sleeved on the outer surface of the shaft rod (41). A bent rod (45) is arranged above the shaft rod (41). One end of the bent rod (45) is fixed to the upper end of the extraction cylinder (1). The other end of the bent rod (45) is rotatably connected to an end plate (46). The end plate (46) is elastically connected to the shaft rod (41). The end plate (46), the shaft rod (41), and the extraction cylinder (1) are coaxial. A vertical rod (47) is fixed to the upper end of the slider (43). The upper end of the vertical rod (47) is fixed to the bent rod (45), and the upper end of the vertical rod (47) is fixed to the end plate (46). The bent rod (45) is equipped with a power rotation structure (48) for controlling the rotation of the shaft rod (41). The upper end of the electric telescopic rod A (13) is rotatably sleeved on the outer surface of the shaft rod (41).

3. The histamine removal and extraction device for kanamycin monosulfate according to claim 2, characterized in that: The lower end of the telescopic stirring rod (42) is a large end, and the large end of the telescopic stirring rod (42) is adapted to the shape of the vertical groove (44).

4. The histamine removal extraction device for kanamycin monosulfate according to claim 2, characterized in that: The power rotation structure (48) includes a motor (481) and a long tooth column (482). A gear (483) is coaxially fixed on the outer surface of the shaft rod (41). The gear (483) meshes with the long tooth column (482). The long tooth column (482) is coaxially fixedly sleeved on the output end of the motor (481). The distance between the upper end face of the gear (483) and the bottom surface of the long tooth column (482) is equal to half of the distance between the bottom surface of the pressing plate (3) and the upper surface of the bottom tray (5).

5. The histamine removal and extraction device for kanamycin monosulfate according to claim 1, characterized in that: The liquid-permeable flexible hose (9) is arranged in a conical spiral. The circumferential side of the bent liquid-permeable rod (11) and the circumferential side of the liquid-permeable end rod (8) at one end inside the bottom tray (5) are liquid-permeable, and the liquid-permeable flexible hose (9) is liquid-permeable.

6. The histamine removal and extraction device for kanamycin monosulfate according to claim 2, characterized in that: The telescopic stirring rod (42) is provided with a convex rod (421) on the upper side of one end of the lower side of the shaft rod (41), and the convex rod (421) is elastically and slidably inserted into the bottom surface of the shaft rod (41).

7. The histamine removal and extraction device for kanamycin monosulfate according to claim 1, characterized in that: The power control structure (7) includes an electric telescopic rod B (71) and a linkage ring (72). The extraction cylinder (1) is coaxially located on the inner ring side of the linkage ring (72). A linkage rod (73) is fixed to the bottom surface of the linkage ring (72). The other end of the linkage rod (73) is fixed to the bottom surface of the bottom tray (5). The end cylinder (2) is slidably sleeved on the outer surface of the linkage rod (73); A transmission rod (74) is fixed to the bottom surface of the liquid tray (6). The other end of the transmission rod (74) slidably penetrates through the inner wall of the end cylinder (2). The upper end of the electric telescopic rod B (71) is fixed to the end cylinder (2), and a bent plate (75) is fixed to the lower end of the electric telescopic rod B (71); A triangular plug (76) is horizontally installed at one end of the transmission rod (74) outside the end cylinder (2). A groove plate (77) is engaged with the other side of the triangular plug (76). A bent elastic telescopic rod (78) is fixed to the upper end surface of the groove plate (77). The upper end of the bent elastic telescopic rod (78) is fixed to the outer ring surface of the linkage ring (72). The upper end of the bent elastic telescopic rod (78) is a horizontal telescopic end. A vertical elastic telescopic rod (79) is fixed to the bottom surface of the horizontal end of the bent elastic telescopic rod (78). The lower end of the vertical elastic telescopic rod (79) is fixed to the transmission rod (74).

8. The histamine removal extraction device for kanamycin monosulfate according to claim 7, characterized in that: A plurality of long grooves (711) are formed on one side of the groove plate (77) close to the end cylinder (2). The upper surface of the triangular plug (76) is inclined. An elastic lifting plate (710) is arranged on the lower side of the transmission rod (74), and the elastic lifting plate (710) is fixed to the bent plate (75); The upper end of the bent plate (75) is bent toward the side away from the end cylinder (2). An elastic push plate (712) is elastically rotatably connected to the bottom surface of the end of the bent plate (75) away from the end cylinder (2). The elastic push plate (712) is located inside one of the long grooves (711). The end of the elastic push plate (712) away from the end cylinder (2) is located below the other end; A support rod (713) is fixed to one side of the outer side of the end cylinder (2) close to the groove plate (77). The other end of the support rod (713) is located inside one of the long grooves (711). The bottom surface of the end of the support rod (713) located inside the long groove (711) is an inclined surface.

9. The histamine removal extraction device for kanamycin monosulfate according to claim 1, characterized in that: The concave ring (10) is coaxially arranged with the bottom tray (5), and the bottom surface of the concave ring (10) is open.

10. The method of using the histamine removal extraction device for kanamycin monosulfate according to any one of claims 1-9, characterized in that, Including the following steps: S1. Put the mother liquor and the ethanol extractant into the extraction cylinder (1), and the stirring structure (4) rotates to increase the mixing effect of the ethanol extractant and the mother liquor; S2. After the extraction is completed, control the liquid tray (6) to move upward relative to the bottom tray (5), move the liquid-permeable part of the liquid-permeable end rod (8) to the upper side of the bottom tray (5), and at the same time move the liquid-permeable part of the bent liquid-permeable rod (11) into the concave ring (10); The liquid in the extraction cylinder (1) flows into the liquid-permeable hose (9) and the liquid-permeable end rod (8). The liquid in the liquid-permeable hose (9) flows into the concave ring (10), flows into the liquid tray (6) through the liquid-permeable part of the bent liquid-permeable rod (11), and the liquid in the liquid-permeable end rod (8) flows into the liquid tray (6). S4. To reduce the liquid residue inside the residue, the electric telescopic rod A (13) controls the pressing plate (3) to move downward to apply pressure to the residue. When the pressing plate (3) applies pressure, the liquid permeable hose (9) is spirally inserted between the residues, and at the same time, the liquid permeable part of the liquid permeable end rod (8) is inserted into the residue; S5. When the pressing plate (3) applies pressure, the liquid in the residue flows out through the liquid permeable hose (9) and the liquid permeable end rod (8) inserted between the residues, preventing the liquid from not flowing out sufficiently when the residue is thick; S6. After driving the pressing plate (3) to move upward, the shaft rod (41) drives the liquid permeable hose (9) and the telescopic stirring rod (42) to rotate again to disperse the compacted residue. Then, when compacting again, the residues contacted by the liquid permeable hose (9) and the liquid permeable end rod (8) are changed, so that the residual liquid inside the residue can be reduced during the reciprocating compaction of the pressing plate (3); S7. Control the bottom tray (5) to move downward to disengage from the extraction cylinder (1), so that the residue on the upper side of the bottom tray (5) can fall into the end cylinder (2), and the liquid in the liquid tray (6) is discharged from the telescopic liquid discharge pipe (12); S8. Add n-pentanol, shake for extraction, combine the filtrates, take the n-pentanol extract in a separatory funnel and extract it with hydrochloric acid 3 times, combine the hydrochloric acid extracts and make up the volume with hydrochloric acid solution. Then add sodium carbonate solution, azo reagent, add water and mix well, add saturated borax solution, stir evenly, add zinc acetate solution, stir, then take the supernatant and centrifuge it in a centrifuge. Take the supernatant after centrifugation and filter it through a 0.22 μm filter membrane to obtain the finished product histamine solution.

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