A method and apparatus for controlling an electrospray ion source for a mass spectrometer

Abstract

Embodiments of the present specification disclose a method and device for controlling an electrospray ion source of a mass spectrometer, electronic equipment and a storage medium. The method comprises obtaining a current value in a capillary and a pressure value of a pneumatic valve, calculating a current deviation value and a pressure deviation value based on the current value and the pressure value; starting a nozzle adjusting motor to clean the nozzle based on a relationship between the current deviation value and a set current deviation threshold value, and adjusting an airflow direction based on a relationship between the pressure deviation value and a set pressure deviation threshold value. Embodiments of the present specification judge whether there is a situation of deposit accumulation or airflow nozzle obstruction by obtaining the current value in the capillary and the pressure value of the pneumatic valve in real time, and start the nozzle adjusting motor to clean the nozzle or adjust the airflow direction in time when an abnormality occurs, thereby avoiding nozzle blockage and ionization efficiency decline, and improving the analysis accuracy of the mass spectrometer and the continuity of the signal.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of mass spectrometry, and in particular to an electrospray ion source control method and device for a mass spectrometer, an electronic device, and a storage medium. BACKGROUND

[0002] Electrospray ionization (ESI) is a widely used ionization technique in mass spectrometry. The core principle is to spray liquid sample from a capillary under the action of high voltage and form charged droplets, and then the droplets gradually dissolve and evaporate under the action of an electric field and eventually decompose into charged ions, which enter the mass spectrometer for analysis. Because the electrospray ionization technique can effectively analyze biological molecules and polypeptides and other large molecule samples by mass spectrometry, and has the characteristics of high sensitivity and high resolution, it has become an important technical means in the fields of life science, environmental science, and drug research.

[0003] In the traditional electrospray ionization technique, the sample is injected from the upstream end of the capillary, and the sample liquid is ionized by the electric field to form charged ions or droplets, which are sprayed into the mass spectrometer. The gas flow spraying method is introduced into the process to prevent the accumulation of solvent residues and pollutants. In order to maintain the stability of the ion current, the traditional method usually uses a fixed capillary position to optimize the ionization efficiency. However, this scheme has limitations in application, especially in the case of high load or long-term operation of complex samples, which can cause problems such as gas flow nozzle blockage, ultimately affecting the analysis accuracy of the mass spectrometer and the continuity of the signal. SUMMARY

[0004] To solve the problems in the prior art, one or more embodiments of the present application describe an electrospray ion source control method and device for a mass spectrometer, an electronic device, and a storage medium.

[0005] According to a first aspect, an electrospray ion source control method for a mass spectrometer is provided, the method comprising:

[0006] Obtaining the current value in the capillary and the pressure value of the pneumatic valve, and calculating the current deviation value and the pressure deviation value based on the current value and the pressure value;

[0007] Based on the relationship between the current deviation value and the set current deviation threshold, the nozzle adjusting motor is started to clean the nozzle, and based on the relationship between the pressure deviation value and the set pressure deviation threshold, the gas flow direction is adjusted.

[0008] Preferably, the method further comprises: determining an adjustment amount of the capillary based on a set first relationship and a set current stability threshold, and adjusting the protruding amount of the capillary based on the adjustment amount of the capillary, so that the corresponding current value of the adjusted protruding amount of the capillary is equal to the current stability threshold.

[0009] Preferably, the first relationship is: wherein I represents the current value in the capillary, d represents the protruding amount of the capillary, k is a constant, and r represents the sensitivity index of the current change with the capillary position change.

[0010] Preferably, the method further comprises: obtaining the capillary port pressure, calculating the current particle flow intensity based on the capillary port pressure, and when the set particle flow intensity threshold is not equal to the current particle flow intensity, determining an adjustment amount of the gas flow rate based on a set second relationship and a set particle flow intensity threshold, and adjusting the gas flow rate based on the adjustment amount of the gas flow rate, so that the corresponding particle flow intensity of the adjusted gas flow rate is equal to the particle flow intensity threshold.

[0011] Preferably, the second relationship is: wherein represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, and K is a constant. and respectively are the influence indexes of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0012] Preferably, the method further comprises: obtaining a pollution signal detected by a pollution sensor, and obtaining a pollutant concentration based on the pollution signal, and outputting an alarm signal when the pollutant concentration is greater than a set pollution threshold.

[0013] Preferably, the method further comprises: outputting an alarm signal if the calculated pollutant concentration exceeds the pollution threshold and the error between the calculated pollutant concentrations is less than a set calibration error threshold within a set calibration frequency threshold.

[0014] According to a second aspect, an electrospray ion source control device for a mass spectrometer is provided, the device comprising:

[0015] a sampling module configured to obtain a current value in a capillary and a pressure value of a pneumatic valve, and calculate a current deviation value and a pressure deviation value based on the current value and the pressure value;

[0016] an execution module configured to start a nozzle adjusting motor to clean a nozzle based on a relationship between the current deviation value and a set current deviation threshold, and adjust the airflow direction based on a relationship between the pressure deviation value and a set pressure deviation threshold.

[0017] According to a third aspect, an electronic device is provided, comprising a processor and a memory;

[0018] The processor is connected with the memory;

[0019] The memory is configured to store executable program code;

[0020] The processor runs a program corresponding to the executable program code by reading the executable program code stored in the memory, to perform the steps of the method provided in the first aspect or any possible implementation manner of the first aspect.

[0021] According to a fourth aspect, a computer readable storage medium is provided, which stores a computer program, and the computer readable storage medium stores instructions, when the instructions are run on a computer or a processor, the computer or the processor performs the method provided in the first aspect or any possible implementation manner of the first aspect.

[0022] The beneficial effects of the present application are:

[0023] 1. The method and device provided by the embodiments of the present application can determine whether the deposition accumulation or the airflow nozzle blockage occurs by acquiring the current value in the capillary and the pressure value of the pneumatic valve in real time, and can clean the nozzle or adjust the airflow direction in time by starting the nozzle adjusting motor when the abnormality occurs, thereby avoiding the nozzle blockage and the ionization efficiency reduction, and improving the analysis accuracy of the mass spectrometer and the continuity of the signal.

[0024] 2. The method and device provided by the embodiments of the present application can adjust the position of the capillary in real time by the current value in the capillary, thereby ensuring the continuous and stable work of the ion source, and effectively improving the accuracy and reliability of the mass spectrum analysis.

[0025] 3. The method and device provided by the embodiments of the present application can adjust the protruding amount of the capillary and the gas flow rate by the current value in the capillary and the capillary port pressure in real time, thereby ensuring the work of the ion source in the optimal state, and improving the ionization efficiency and the stability of the ion flow, and avoiding the detection error caused by the fluctuation.

[0026] 4. The method and device provided by the embodiments of the present application can detect the pollutant concentration in real time by the pollution sensor and trigger the alarm, thereby prewarning when the pollution degree has not seriously affected the analysis, reducing the risk of sudden failure, and ensuring the stable operation of the instrument. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed in the embodiments. Obviously, the drawings in the following description only constitute some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative effort.

[0028] Figure 1 is a flowchart of a method for controlling an electrospray ion source of a mass spectrometer in the specific implementation of the present specification;

[0029] Figure 2 is a first execution schematic diagram of a method for controlling an electrospray ion source of a mass spectrometer in the specific implementation of the present specification;

[0030] Figure 3 is a second execution schematic diagram of a method for controlling an electrospray ion source of a mass spectrometer in the specific implementation of the present specification;

[0031] Figure 4 is a third execution schematic diagram of a method for controlling an electrospray ion source of a mass spectrometer in the specific implementation of the present specification;

[0032] Figure 5 is a structural schematic diagram of a device for controlling an electrospray ion source of a mass spectrometer in the specific implementation of the present specification;

[0033] Figure 6 is a structural schematic diagram of an electronic device in the specific implementation of the present specification. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application.

[0035] In the following description, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance. The following description provides a plurality of embodiments of the present application, and different embodiments can be replaced or combined, so the present application can also be considered to include all possible combinations of the same and / or different embodiments described. Therefore, if one embodiment includes features A, B, C, and another embodiment includes features B, D, the present application should also be considered to include one or more embodiments of all other possible combinations of A, B, C, and D, although the embodiment may not be explicitly described in the following content.

[0036] The following description provides examples, and is not intended to limit the scope, applicability or examples set forth in the claims. Changes can be made in the function and arrangement of elements without departing from the scope of the application. Various examples can omit, substitute, or add various procedures or components as appropriate. For instance, the methods described can be performed in an order different than described, and various steps can be added, omitted, or combined. Also, features described with respect to some examples can be combined in other examples.

[0037] Referring to Figure 1 , Figure 1 is a flowchart of a method for controlling an electrospray ion source of a mass spectrometer. In the present embodiment, the method comprises:

[0038] S101, obtaining a current value in the capillary and a pressure value of the pneumatic valve, and calculating a current deviation value and a pressure deviation value based on the current value and the pressure value;

[0039] S102, starting the nozzle adjusting motor to clean the nozzle based on the relationship between the current deviation value and a set current deviation threshold value, and adjusting the airflow direction based on the relationship between the pressure deviation value and a set pressure deviation threshold value.

[0040] The execution subject of the present application can be a PLC controller of an electrospray ionization device.

[0041] In the present embodiment, referring to Figure 1 , Figure 2 , the capillary is electrically connected with a current detection circuit, the current detection circuit detects the current value in the capillary in real time, and compares the current value with a preset current value to obtain a current deviation value. Assuming that the current value in the capillary is I, and the preset current value is I0, the current deviation value calculation formula is , wherein , the current detection circuit sends an electric signal representing the current deviation value to the PLC controller. The pressure detection circuit is electrically connected with the pneumatic valve, the pressure detection circuit detects the pressure value of the airflow at the pneumatic valve in real time, and compares the pressure value with a preset pressure value to obtain a pressure deviation value. Assuming that the pressure value of the airflow at the pneumatic valve is P, and the preset pressure value is P0, the pressure deviation value calculation formula is , wherein , and , wherein The pressure deviation value, the pressure detection circuit sends an electric signal representing the pressure deviation value to the PLC controller. The operator will pre-set the current deviation threshold and the pressure deviation threshold. After receiving the current deviation value and the pressure deviation value, the PLC controller compares the current deviation value with the current deviation threshold. When the current deviation value is greater than the current deviation threshold, it indicates that there is a deposit accumulation in the airflow nozzle, the resistance of the nozzle airflow channel increases, resulting in an excessive current value in the capillary. At this time, the PLC controller starts the nozzle adjusting motor to clean the nozzle. When the pressure deviation value is greater than the pressure deviation threshold, it indicates that the airflow nozzle is blocked. At this time, the PLC controller adjusts the airflow direction. In this application, the current value in the capillary and the pressure value of the pneumatic valve are obtained in real time to determine whether there is a deposit accumulation or a blocked airflow nozzle. When an abnormality occurs, the nozzle adjusting motor is started to clean the nozzle or the airflow direction is adjusted in time, avoiding nozzle blockage and ionization efficiency reduction, and improving the analysis accuracy of the mass spectrometer and the continuity of the signal.

[0042] It should be noted that the current detection circuit includes a current collection resistor and an operational amplifier. The first end of the current collection resistor is electrically connected to the first end of the capillary, the second end of the current collection resistor is connected to a voltage input, the second end of the capillary is grounded, the first input end of the operational amplifier is electrically connected to the first end of the current collection resistor, the second input end of the operational amplifier is electrically connected to the second end of the current collection resistor, and the output end of the operational amplifier is electrically connected to the PLC controller. The pressure detection circuit includes a voltage dividing resistor, a pressure sensitive resistor, and a comparator. The first interface of the comparator is connected to a pre-set pressure value voltage input, the second interface of the comparator is electrically connected to the first end of the voltage dividing resistor and the first end of the pressure sensitive resistor, the second end of the voltage dividing resistor is connected to a voltage input, the second end of the pressure sensitive resistor is grounded, and the third interface of the comparator is electrically connected to the PLC controller.

[0043] In one implementation manner, referring to Figure 3 , a first relationship between the current value in the capillary and the protrusion amount of the capillary is established. When the current detection circuit detects that the current value in the capillary is not equal to the current stable threshold, the PLC controller controls the mechanical assembly to adjust the protrusion amount of the capillary according to the first relationship, so that the current value in the capillary corresponding to the adjusted protrusion amount of the capillary is equal to the current stable threshold. For example, the current stable threshold is set to 150 mA, the initial protrusion amount is 1 mm, and when the current rises to 600 mA, the PLC controller adjusts the position of the capillary to reduce the protrusion amount, so that the current returns to 150 mA. By adjusting the position of the capillary in real time according to the current value in the capillary, the continuous and stable operation of the ion source is ensured, and the accuracy and reliability of the mass spectrometry are effectively improved.

[0044] Specifically, the first relationship is: wherein I represents the current value in the capillary, d represents the protrusion amount of the capillary, k is a constant, and r represents a sensitivity index of the current change with the capillary position change.

[0045] In an implementation, a second relationship between the gas flow rate and the capillary port pressure is established, the PLC controller acquires the capillary port pressure and the gas flow rate, calculates the current particle flow intensity according to the capillary port pressure and the gas flow rate, sets a particle flow intensity threshold, and when the particle flow intensity threshold is not equal to the current particle flow intensity, the PLC controller changes the gas flow rate so that the corresponding particle flow intensity after the change of the gas flow rate is equal to the particle flow intensity threshold. Specifically, the gas flow rate can be changed by changing the opening of the pneumatic valve, and the gas flow direction can be changed by changing the opening direction of the pneumatic valve. In the present application, the protrusion amount of the capillary and the gas flow rate are adjusted by real-time acquisition of the current value in the capillary and the capillary port pressure, so as to ensure that the ion source works in an optimal state, thereby improving the ionization efficiency and the stability of the ion flow and avoiding detection errors caused by fluctuations.

[0046] Specifically, the second relationship is: wherein represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, and k is a constant, and r respectively represent the influence indexes of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0047] In an implementation, referring to Figure 4 The pollution sensor is arranged in the gas flow protection cover, and is used to detect the concentration of pollutants in the equipment. The PLC controller calculates the concentration of pollutants according to the pollution signal transmitted by the pollution sensor, and triggers an alarm when the concentration of pollutants exceeds a preset pollution threshold. The process of calculating the concentration of pollutants by the pollution sensor is C=S*G, wherein C represents the concentration of pollutants, S is the pollution signal output by the pollution sensor, and G is the sensitivity coefficient of the pollution sensor. Real-time detection of the concentration of pollutants by the pollution sensor and triggering of the alarm can provide early warning when the pollution degree has not yet seriously affected the analysis, thereby reducing the risk of sudden failure and ensuring stable operation of the instrument.

[0048] Further, a calibration frequency threshold and a calibration error threshold are set, if the calculated pollutant concentration exceeds the pollution threshold each time within the calibration frequency threshold, and the error between the calculated pollutant concentration each time is less than the calibration error threshold, an alarm signal is output, by setting the calibration frequency threshold and the calibration error threshold, false alarm of the system is avoided, the accuracy of the alarm is improved, and false alarm caused by the change of the sensitivity of the pollution sensor in the long-term use is avoided. For example, the calibration frequency threshold is set to 3 times, and the calibration error threshold is set to 2%, if the calculated pollutant concentration exceeds the pollution threshold for three times in succession and the error between each time is less than 2%, the PLC controller will directly alarm and prompt maintenance.

[0049] The application will be described in detail below with reference to the accompanying drawings. Figure 5 The application will be described in detail below with reference to the accompanying drawings. Figure 5 The application will be described in detail below with reference to the accompanying drawings. Figure 1 The application will be described in detail below with reference to the accompanying drawings. Figure 1 The application will be described in detail below with reference to the accompanying drawings.

[0050] The application will be described in detail below with reference to the accompanying drawings. Figure 5 , Figure 5 The application will be described in detail below with reference to the accompanying drawings. Figure 5 The application will be described in detail below with reference to the accompanying drawings.

[0051] The sampling module 201 is used to obtain the current value in the capillary and the pressure value of the pneumatic valve, and the current deviation value and the pressure deviation value are calculated based on the current value and the pressure value;

[0052] The execution module 202 is used to start the nozzle adjusting motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold, and adjust the airflow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold.

[0053] In an implementation manner, the execution module 202 is specifically used for:

[0054] The method further includes: determining the adjustment amount of the capillary based on the set first relationship and the set current stability threshold, and adjusting the protruding amount of the capillary based on the adjustment amount of the capillary, so that the current value corresponding to the adjusted protruding amount of the capillary is equal to the current stability threshold.

[0055] In an implementation manner, the execution module 202 is specifically used for:

[0056] The first relationship is: wherein I represents a current value in the capillary, d represents a protrusion amount of the capillary, k is a constant, and r represents a sensitivity index of current variation with capillary position variation.

[0057] In an implementation, the execution module 202 is specifically configured to:

[0058] The capillary port pressure is obtained, and a current particle flow intensity is calculated based on the capillary port pressure; when a set particle flow intensity threshold is not equal to the current particle flow intensity, an adjustment amount of the gas flow rate is determined based on a set second relationship and the set particle flow intensity threshold, and the gas flow rate is adjusted based on the adjustment amount of the gas flow rate, so that a particle flow intensity corresponding to the adjusted gas flow rate is equal to the particle flow intensity threshold.

[0059] In an implementation, the execution module 202 is specifically configured to:

[0060] The second relationship is: wherein represents a particle flow intensity, represents a gas flow rate, represents a capillary port pressure, and k is a constant. and r respectively represent influence indexes of the gas flow rate and the capillary port pressure on the ion flow intensity.

[0061] In an implementation, the execution module 202 is specifically configured to:

[0062] A pollution signal detected by a pollution sensor is obtained, and a pollutant concentration is obtained based on the pollution signal; when the pollutant concentration is greater than a set pollution threshold, an alarm signal is output.

[0063] In an implementation, the execution module 202 is specifically configured to:

[0064] If the calculated pollutant concentration exceeds the pollution threshold within a set calibration times threshold, and the error between the calculated pollutant concentrations is less than a set calibration error threshold, an alarm signal is output.

[0065] Those skilled in the art can clearly understand that the technical solutions of the embodiments of the present application can be implemented by means of software and / or hardware. The "unit" and "module" in the specification refer to software and / or hardware that can independently complete or cooperate with other components to complete a specific function, wherein the hardware can be, for example, a Field-Programmable Gate Array (FPGA), an Integrated Circuit (IC), and the like.

[0066] The processing units and / or modules of the embodiments of the present application can be implemented by analog circuits that implement the functions of the embodiments of the present application, or can be implemented by software that implements the functions of the embodiments of the present application.

[0067] Referring to Figure 6 , a structural schematic diagram of an electronic device related to the embodiments of the present application is shown, which can be used to implement the method in the embodiments shown in Figure 1 . As shown in Figure 6 , the electronic device 300 can include at least one central processor 301, at least one network interface 304, a user interface 303, a memory 305, and at least one communication bus 302.

[0068] The communication bus 302 is used to realize the connection and communication between the components.

[0069] The user interface 303 can include a display screen (Display) and a camera (Camera), and the optional user interface 303 can further include a standard wired interface and a wireless interface.

[0070] The network interface 304 can optionally include a standard wired interface and a wireless interface (such as a WI-FI interface).

[0071] The central processor 301 can include one or more processing cores. The central processor 301 connects various parts in the entire electronic device 300 through various interfaces and lines, executes various functions of the terminal 300 and processes data by running or executing instructions, programs, code sets or instruction sets stored in the memory 305, and calling data stored in the memory 305. Optionally, the central processor 301 can be implemented in at least one of the following hardware forms: Digital Signal Processing (DSP), Field-Programmable Gate Array (FPGA), and Programmable Logic Array (PLA). The central processor 301 can integrate one or several combinations of Central Processing Unit (CPU), Graphics Processing Unit (GPU), and modem. Among them, the CPU mainly processes the operating system, user interface, and application programs; the GPU is responsible for rendering and drawing the content to be displayed on the display screen; and the modem is used for processing wireless communication. It can be understood that the above-mentioned modem can also not be integrated into the central processor 301, but can be implemented by a separate chip.

[0072] The memory 305 can include a random access memory (RAM) and a read-only memory (ROM). Optionally, the memory 305 includes a non-transitory computer-readable storage medium. The memory 305 can be used to store instructions, programs, codes, code sets, or instruction sets. The memory 305 can include a program storage area and a data storage area, where the program storage area can store instructions for implementing an operating system, instructions for at least one function (such as a touch function, a sound playing function, an image playing function, etc.), instructions for implementing the above various method embodiments, etc.; and the data storage area can store data involved in the above various method embodiments, etc. The memory 305 can also be at least one storage device located away from the central processing unit 301. As shown in Figure 6 The memory 305 as a computer storage medium can include an operating system, a network communication module, a user interface module, and program instructions.

[0073] In the electronic device 300 as shown in Figure 6 The user interface 303 is mainly used to provide an interface for user input and obtain user input data; and the central processing unit 301 can be used to call an application stored in the memory 305 and specifically perform the following operations:

[0074] S101, obtaining a current value in a capillary and a pressure value of a pneumatic valve, and calculating a current deviation value and a pressure deviation value based on the current value and the pressure value;

[0075] S102, starting a nozzle adjusting motor to clean a nozzle based on a relationship between the current deviation value and a set current deviation threshold value, and adjusting an airflow direction based on a relationship between the pressure deviation value and a set pressure deviation threshold value.

[0076] The application also provides a computer readable storage medium having a computer program stored thereon, the program being executed by a processor to implement the steps of the above method. The computer readable storage medium can include but is not limited to any type of disk, including a floppy disk, an optical disk, a DVD, a CD-ROM, a micro drive, and a magneto-optical disk, a ROM, a RAM, an EPROM, an EEPROM, a DRAM, a VRAM, a flash memory device, a magnetic card or an optical card, a nanosystem (including a molecular memory IC), or any type of medium or device suitable for storing instructions and / or data.

[0077] It should be noted that, for the foregoing method embodiments, the sequences of the described actions are not necessarily required to achieve the objects of the application, and certain acts can be performed in other sequences, or even concurrently. Additionally, the described embodiments are merely provided as examples, and not all of the actions listed can be required in all embodiments.

[0078] In the above embodiments, the description of each embodiment is focused on different aspects, and the parts not described in detail in a certain embodiment can be referred to the relevant description of other embodiments.

[0079] In several embodiments provided in the present application, it should be understood that the disclosed apparatus can be implemented in other ways. For example, the apparatus embodiments described above are merely schematic. For example, the division of the units is merely a logical function division. In actual implementation, another division manner can be adopted. For example, a plurality of units or components can be combined or integrated into another system, or some features can be omitted or not executed. In addition, the coupling or direct coupling or communication connection between the units shown or discussed can be indirect coupling or communication connection through some service interfaces. The coupling or communication connection can be electrical or other forms.

[0080] The units described as separate components can or can not be physically separate, and the components shown as units can or can not be physical units, i.e. can be located in one place, or can be distributed on a plurality of network units. Part or all of the units can be selected according to actual needs to achieve the purpose of the embodiment.

[0081] In addition, each functional unit in each embodiment of the present application can be integrated in one processing unit, or each unit can be physically present separately, or two or more units can be integrated in one unit. The integrated unit can be realized in the form of hardware or in the form of a software functional unit.

[0082] The integrated unit, if implemented in the form of a software function unit and sold or used as an independent product, can be stored in a computer readable memory. Based on such understanding, the technical solutions of the present application essentially or the part that contributes to the prior art or the whole or part of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a memory and includes a plurality of instructions for causing a computer device (which can be a personal computer, a server or a network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned memory includes: a U disk, a read-only memory (ROM), a random access memory (RAM), a mobile hard disk, a magnetic disk or an optical disk, and various media that can store program codes.

[0083] A person of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be performed by a program instructing relevant hardware, and the program can be stored in a computer readable memory, which can include a flash disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0084] The above is only exemplary embodiments of the present disclosure, and cannot limit the scope of the present disclosure. That is, any equivalent changes and modifications made in accordance with the teachings of the present disclosure are still within the scope of the present disclosure. Those skilled in the art will easily think of embodiments of the present disclosure after considering the specification and practicing the disclosure herein. The present application is intended to cover any variations, uses or adaptive changes of the present disclosure, which follow the general principles of the present disclosure and include common knowledge or conventional technical means in the technical field not disclosed in the present disclosure. The specification and examples are only considered as exemplary, and the scope and spirit of the present disclosure are defined by the claims.

Claims

1. A method of controlling an electrospray ion source for a mass spectrometer, the method comprising: The method comprises: obtaining the current value in the capillary and the pressure value of the pneumatic valve, and calculating the current deviation value and the pressure deviation value based on the current value and the pressure value; starting the nozzle adjusting motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold value, and adjusting the airflow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold value; The method further comprises: obtaining a pollution signal detected by a pollution sensor, obtaining a pollutant concentration based on the pollution signal, and outputting an alarm signal when the pollutant concentration is greater than a set pollution threshold; the method further comprises: if the calculated pollutant concentration exceeds the pollution threshold within a set calibration frequency threshold, and the error between the calculated pollutant concentration each time is less than a set calibration error threshold, an alarm signal is output; determining the adjustment amount of the capillary based on a set first relationship and a set current stability threshold value, and adjusting the protruding amount of the capillary based on the adjustment amount of the capillary, so that the current value corresponding to the adjusted protruding amount of the capillary is equal to the current stability threshold value.

2. A method of controlling an electrospray ion source for a mass spectrometer as defined in claim 1, wherein, The first relationship is: where I represents the current value in the capillary, d represents the protrusion amount of the capillary, k is a constant, and r represents a sensitivity index of the current change with respect to the capillary position change.

3. The method of claim 1, wherein the method further comprises: The method further comprises: obtaining the capillary port pressure, calculating the current particle flow intensity based on the capillary port pressure, and when the set particle flow intensity threshold value is not equal to the current particle flow intensity, determining the adjustment amount of the gas flow rate based on a set second relationship and a set particle flow intensity threshold value, and adjusting the gas flow rate based on the adjustment amount of the gas flow rate, so that the adjusted gas flow rate corresponds to the particle flow intensity equal to the particle flow intensity threshold value.

4. A method of controlling an electrospray ion source for a mass spectrometer as defined in claim 3, wherein, The second relationship is: wherein represents the particle flow intensity, represents the gas flow rate, represents the capillary port pressure, K is a constant, are the influence exponents of the gas flow rate and the capillary port pressure on the ion flow intensity, respectively.

5. An electrospray ion source control device for a mass spectrometer, characterized by, The device comprises: a sampling module for obtaining the current value in the capillary and the pressure value of the pneumatic valve, and calculating the current deviation value and the pressure deviation value based on the current value and the pressure value; an execution module for starting the nozzle adjusting motor to clean the nozzle based on the relationship between the current deviation value and the set current deviation threshold value, and adjusting the airflow direction based on the relationship between the pressure deviation value and the set pressure deviation threshold value; The electrospray ion source control device executes the steps of the method according to any one of claims 1-4.

6. An electronic device comprising a memory, a processor, and a computer program stored on the memory and executable on the processor, characterized in that, The processor executes the computer program to implement the steps of the method according to any one of claims 1-4.

7. A computer readable storage medium having a computer program stored thereon, the computer readable storage medium having instructions stored therein, when the instructions are executed on a computer or processor, causing the computer or processor to execute the steps of the method according to any one of claims 1-4.

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