Processing method for preventing topramezone from being decomposed in multi-element compound solid preparation

Abstract

The invention relates to the technical field of plant growth regulators, in particular to a processing method for preventing topramezone from being decomposed in a multi-element compound solid preparation. The ultraviolet resistance is improved through combination of cellulose and functionalized ammonium phosphomolybdate, the modified cellulose is added into the preparation, after the modified cellulose is prepared into a solution, a protective film can be formed on the surface of an active component, and the topramezone can be protected from photolysis through the enhanced ultraviolet resistance of the modified cellulose. The composition is reasonable in component compounding, the control effect on weeds in the corn field is improved, the control spectrum of the weeds in the corn field is expanded, and the pesticide application period is prolonged.

Description

Technical Field

[0001] The present invention relates to the technical field of plant growth regulators, and particularly relates to a processing method for preventing the decomposition of topramezone in a multiple compound solid preparation. Background Art

[0002] Topramezone is a herbicide developed by BASF in Germany and belongs to the class of benzoylpyrazolone herbicides. It is a kind of HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitor. It is a broad-spectrum, safe and systemic post-emergence herbicide for corn fields, which can effectively control various gramineous and broad-leaved weeds on corn crops. Even at high doses, it also has a certain inhibitory effect on Cyperaceae weeds. Topramezone shows a high degree of safety to corn varieties and is also safe for the subsequent crops after planting.

[0003] CN108887266A relates to a dry suspension containing pinoxaden and topramezone. The dispersant in the suspension is a composite dispersant of lignosulfonate and a compound selected from alkylphenol polyoxyethylene ether formaldehyde condensate or fatty alcohol polyoxyethylene ether sulfate, and the weight ratio of the two is 5:1 - 2:1; the lignosulfonate is sodium lignosulfonate or calcium lignosulfonate. The pinoxaden and topramezone dry suspension of this invention has good dispersion and suspension properties in terms of performance, can form a homogeneous suspension system during use, and is used for post-emergence stem and leaf spraying for weed control, saving labor and time; in particular, due to the selection of a specific composite dispersant, the dry suspension of this invention has excellent stability, especially excellent thermal storage stability.

[0004] CN117413827A relates to the technical field of pesticides, and specifically relates to a topramezone-containing suspension and its preparation method and application. The suspension includes: 20 - 40 wt% of topramezone technical, 3 - 5 wt% of dispersant, 2 - 3 wt% of wetting agent, 0.05 - 0.2 wt% of defoamer, 0.08 - 1.2 wt% of inorganic salt, 0.9 - 1.3 wt% of thickener, 0 - 0.5 wt% of other auxiliary materials, and the balance is water. The topramezone-containing suspension of this invention has the advantages of excellent stability and a long effective time of the active ingredient.

[0005] The photolysis and hydrolysis rates of topramezone are different under different conditions. The photolysis is the fastest in an acetonitrile environment and the slowest in a methanol environment. Temperature has a significant impact on the hydrolysis rate. The hydrolysis rate at 50°C is about 10 times that at room temperature. Humic acid has an inhibitory effect on the hydrolysis and photolysis of topramezone. Temperature is an important factor affecting the stability of the preparation. Generally speaking, an increase in temperature will accelerate the degradation rate of the drug. Therefore, in the traditional processing method of multiple compound solid formulations containing topramezone, there are quality problems such as gas swelling, color change, and decomposition of topramezone during long-term storage, which affect the efficacy of the product and do not meet the national quality standards. Summary of the Invention

[0006] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide a processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation.

[0007] Topramezone is a pesticidal active ingredient. When mixed with MCPA-Na, ametryn, and other auxiliaries to prepare a solid powder, quality problems such as bloating, discoloration, and decomposition may occur during long-term storage. These phenomena may be caused by the following factors: Topramezone may be sensitive to environmental conditions and is prone to chemical changes during storage, especially under high-temperature or light conditions; during long-term storage, topramezone may react with oxygen in the air, resulting in oxidation, which may cause discoloration and decomposition. If the moisture in the solid powder is not properly controlled, the penetration of moisture may cause hydrolysis of topramezone or chemical reactions with other components, resulting in bloating and discoloration. The stability of topramezone may be affected by the pH value. If the pH value of the powder changes, it may affect its chemical structure and cause decomposition. The auxiliaries used may change during long-term storage, affecting the stability and efficacy of the powder.

[0008] In the processing of wettable powders, carriers or fillers play a crucial role. The main function of these inert substances is to ensure the content of the active ingredient of pesticides in the product and to promote the uniform mixing of the active ingredient of the technical material with other components such as surfactants. In this way, they not only help to maintain the dispersibility and fluidity of the product, but also improve the overall performance of the product, enabling it to be safely and conveniently diluted in water during use. Usually, substances with strong adsorption capacity, such as diatomaceous earth, bentonite, attapulgite and silica white, are used as carriers. These carriers not only serve as the matrix of the wettable powder, but can also act as fillers for the product. In contrast, substances with low or medium adsorption capacity, such as talc, pyrophyllite, clays (such as kaolin, pottery clay, etc.), are usually used as fillers or diluents. Whether it is a carrier or a filler, their core role is to carry or dilute the inert components of pesticides, giving the pesticide formulation products fluidity, dispersibility and ease of use. The adsorption capacity of the carrier or filler is one of its most important characteristics, which can evenly distribute the active ingredient of pesticides on fine particles. Factors such as the distribution range of fine particles and the bulk density will affect the coverage of the active ingredient of pesticides, wind drift, leaf penetration, sedimentation in water, and the processing difficulty of the formulation. When selecting a carrier or filler, in addition to considering its adsorption capacity, it is also necessary to consider its compatibility with the active ingredient of pesticides. For example, under long-term high-temperature storage conditions, the chemical stability of benzobicyclon may decrease, which is not only related to its own degradation, but may also be related to the acidic, basic and catalytic active sites on the particles of the carrier or filler used. To improve the stability of the solid powder and extend its storage time, appropriate stabilizers can be added to ensure the stability of the active ingredient.

[0009] The stability of cellulose within a certain pH range, its tolerance to heat and light, and the high-viscosity environment formed by it in aqueous solution work together to reduce the contact between the active ingredient and the external environment and reduce the risk of chemical reactions such as oxidation and hydrolysis. In addition, its thickening effect helps to improve the physical stability of the powder, preventing the settlement and separation of components and further extending the shelf life of the product. However, it cannot effectively prevent the degradation of benzobicyclon under light. Therefore, the present invention provides a modified cellulose, whose ultraviolet resistance is enhanced by its combination with functionalized ammonium phosphomolybdate. As a polyacid, ammonium phosphomolybdate not only has antibacterial properties but also has an ultraviolet absorption function. Therefore, after the modified cellulose is formulated into a solution in the powder, a protective film is formed on the surface of the active ingredient, and its enhanced ultraviolet resistance can protect benzobicyclon from photolysis, thereby enhancing the stability.

[0010] To achieve the above object, the present invention provides a processing method for preventing the decomposition of benzobicyclon in a multi-component compound solid preparation, including the following steps, in parts by weight:

[0011] S1. Mix 10 - 20 parts of MCPA - sodium, 50 - 60 parts of ametryn, 2 - 5 parts of dispersant, 1 - 5 parts of wetting agent, 1 - 2 parts of thickener, 1 - 2 parts of modified cellulose, 0.01 - 1 part of inorganic salt, and 10 - 20 parts of inorganic filler evenly. After airflow comminution, it is reserved for later use.

[0012] S2. After airflow comminution of 5 - 10 parts of topramezone, mix it evenly with the mixture in S1.

[0013] Further, the dispersant is one of lignosulfonate, polycarboxylate, alkylnaphthalenesulfonate, and sodium dodecylbenzenesulfonate.

[0014] Further, the wetting agent is one of fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether, or sorbitan fatty acid ester polyoxyethylene ether.

[0015] Further, the thickener is one of xanthan gum, sodium polyacrylate, or magnesium aluminum silicate.

[0016] Further, the inorganic salt is one of ammonium sulfate, ammonium nitrate, or potassium dihydrogen phosphate.

[0017] Further, the inorganic filler is one of diatomite, montmorillonite, or kaolin.

[0018] Further, the pressure of the airflow comminution is 0.3 - 0.5 MPa, and the particle size of the comminution is 40 - 50 μm.

[0019] The preparation method of the modified cellulose includes the following steps:

[0020] X1. Add cellulose to 1 - hexyl - 3 - methylimidazolium chloride, heat to 70 - 80 °C and stir for 1 - 2 h. Then add Span 60, epichlorohydrin, and sodium hypophosphite. After adding, cool to 50 - 60 °C, add toluene and continue to stir for 2 - 3 h, then centrifuge. After removing the supernatant, freeze - dry for the next step.

[0021] X2. Add lauryl trimethyl ammonium bromide to ethanol, heat to 50 - 60 °C and then add the product of the previous step. Continue to stir for 6 - 10 h, then add ethanol for washing and centrifuge. After removing the supernatant, the freeze - dried product is added to ethanol and mixed with a 10 - 20 wt% ammonium phosphomolybdate solution. Stir evenly and then add to an autoclave for ion exchange at 70 - 80 °C for 20 - 30 h. After centrifugation, discard the supernatant, wash with ethanol, and freeze - dry to obtain.

[0022] Further, the mass ratio of cellulose to 1 - hexyl - 3 - methylimidazolium chloride, Span 60, epichlorohydrin, and sodium hypophosphite is 3 - 4:100 - 150:2 - 3:2 - 3:0.4 - 1.

[0023] Furthermore, the mass ratio of lauryl trimethyl ammonium bromide, the product of the previous step, and ammonium phosphomolybdate is 1:1:3 - 5.

[0024] Preferably, the preparation method of the modified cellulose comprises the following steps:

[0025] X1. Add cellulose into 1-hexyl-3-methylimidazolium chloride, heat to 70 - 80 °C and stir for 1 - 2 h. Then add Span 60, epichlorohydrin, and sodium hypophosphite. The mass ratio of cellulose to 1-hexyl-3-methylimidazolium chloride, Span 60, epichlorohydrin, and sodium hypophosphite is 3 - 4:100 - 150:2 - 3:2 - 3:0.4 - 1. After adding, cool down to 50 - 60 °C, add toluene and continue to stir for 2 - 3 h, then centrifuge. Remove the supernatant and freeze-dry for the next step.

[0026] X2. Add lauryl trimethyl ammonium bromide into ethanol, heat to 50 - 60 °C and then add it to the product of the previous step. Continue to stir for 6 - 10 h, then add ethanol for washing and centrifuge. After removing the supernatant and freeze-drying the obtained product, add it to ethanol and mix with a 10 - 20 wt% ammonium phosphomolybdate solution. The mass ratio of lauryl trimethyl ammonium bromide, the product of the previous step, and ammonium phosphomolybdate is 1:1:3 - 5. Stir evenly and add it to an autoclave for ion exchange at 70 - 80 °C. After 20 - 30 h, centrifuge, discard the supernatant, wash with ethanol, and freeze-dry to obtain.

[0027] Advantages of the present invention:

[0028] 1. Compared with the prior art, the present method adopts a specific processing method and formula, solves problems such as the easy decomposition of tembotrione, and improves the quality and stability of the product.

[0029] 2. The present invention improves the ultraviolet resistance through the combination of cellulose and functionalized ammonium phosphomolybdate. As a polyacid, ammonium phosphomolybdate not only has antibacterial properties but also has an ultraviolet absorption function. Therefore, after the modified cellulose is formulated into a solution in the powder, a protective film is formed on the surface of the active ingredient, and its enhanced ultraviolet resistance can protect tembotrione from photolysis. Specific embodiments

[0030] The technical solutions of the present invention will be described clearly and completely below. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the scope of protection of the present invention.

[0031] Fatty alcohol polyoxyethylene ether, AEO-7, Shandong Qiyi Chemical Industry.

[0032] Cellulose, particle size: 50 μm, Aladdin.

[0033] Diatomaceous earth, 200 mesh.

[0034] Example 1

[0035] A processing method for preventing fenpyroxil from decomposing in a multi-component solid preparation comprises the following steps, measured in parts by weight:

[0036] S1, after uniformly mixing 12 parts of dimethyl tetrachloride sodium, 50 parts of ametryn, 5 parts of sodium dodecylbenzene sulfonate, 4 parts of fatty alcohol polyoxyethylene ether, 1 part of magnesium aluminum silicate, 1.5 parts of modified cellulose, 1 part of potassium dihydrogen phosphate, and 17.5 parts of diatomaceous earth, the mixture was crushed to 45 μm by 0.4 MPa airflow and then used for later use;

[0037] S2, crush 8 parts of fenpyroxetine with 0.4 MPa air flow to 45 μm and mix well with the mixture in S1 to obtain the product.

[0038] The preparation method of the modified cellulose comprises the following steps, measured in parts by weight:

[0039] X1. Add 3 parts of cellulose to 100 parts of 1-hexyl-3-methylimidazole chloride, heat to 80°C and stir for 2 hours, then add 3 parts of Span 60, 3 parts of epichlorohydrin and 0.6 parts of sodium hypophosphite. After the addition is complete, cool to 60°C, add 20 parts of toluene and continue stirring for 3 hours, then centrifuge, remove the supernatant and freeze-dry for the next step;

[0040] X2. Add 2 parts of lauryltrimethylammonium bromide to 100 parts of ethanol, heat to 60°C, then add 2 parts of the product from the previous step, continue stirring for 8 hours, wash with ethanol, centrifuge, remove the supernatant and freeze-dry the obtained product, add it to 100 parts of ethanol and 60 parts of 10wt% ammonium phosphomolybdate solution, stir evenly, then add it to an autoclave for ion exchange at 80°C, centrifuge after 24 hours, discard the supernatant, wash with ethanol, and freeze-dry.

[0041] Example 2

[0042] It is basically the same as Example 1, except that the weight portion of modified cellulose is 1 part.

[0043] Example 3

[0044] It is basically the same as Example 1, except that the weight portion of modified cellulose is 2 parts.

[0045] Comparative Example 1

[0046] A processing method for preventing fenpyroxil from decomposing in a multi-component solid preparation comprises the following steps, measured in parts by weight:

[0047] S1. Mix 12 parts of MCPA-sodium, 50 parts of ametryn, 5 parts of dodecylbenzenesulfonic acid sodium, 4 parts of fatty alcohol polyoxyethylene ether, 1 part of magnesium aluminum silicate, 1 part of potassium dihydrogen phosphate, and 19 parts of diatomite evenly, and then grind them to 45 μm by airflow pulverization under 0.4 MPa for standby;

[0048] S2. Grind 8 parts of tembotrione to 45 μm by airflow pulverization under 0.4 MPa, and then mix it evenly with the mixture in S1 to obtain the product.

[0049] Control Example 2

[0050] A processing method for preventing the decomposition of tembotrione in a multi-component compound solid preparation, comprising the following steps, in parts by weight:

[0051] S1. Mix 12 parts of MCPA-sodium, 50 parts of ametryn, 5 parts of dodecylbenzenesulfonic acid sodium, 4 parts of fatty alcohol polyoxyethylene ether, 1 part of magnesium aluminum silicate, 1.5 parts of cellulose, 1 part of potassium dihydrogen phosphate, and 17.5 parts of diatomite evenly, and then grind them to 45 μm by airflow pulverization under 0.4 MPa for standby;

[0052] S2. Grind 8 parts of tembotrione to 45 μm by airflow pulverization under 0.4 MPa, and then mix it evenly with the mixture in S1 to obtain the product.

[0053] Control Example 3

[0054] A processing method for preventing the decomposition of tembotrione in a multi-component compound solid preparation, comprising the following steps, in parts by weight:

[0055] S1. Mix 12 parts of MCPA-sodium, 50 parts of ametryn, 5 parts of dodecylbenzenesulfonic acid sodium, 4 parts of fatty alcohol polyoxyethylene ether, 1 part of magnesium aluminum silicate, 1.5 parts of sodium carboxymethyl cellulose, 1 part of potassium dihydrogen phosphate, and 17.5 parts of diatomite evenly, and then grind them to 45 μm by airflow pulverization under 0.4 MPa for standby;

[0056] S2. Grind 8 parts of tembotrione to 45 μm by airflow pulverization under 0.4 MPa, and then mix it evenly with the mixture in S1 to obtain the product.

[0057] Test Example 1

[0058] Carry out a field efficacy test for controlling weeds in corn fields to verify the control effect of the multi-component compound solid preparation prepared by the present invention on weeds in corn fields and its safety for corn. The test crop is corn, and the control object is weeds in corn fields (broad-leaved weeds, Gramineae), and the leaf age of the weeds is in the 2-5 leaf stage. The test field is flat, the soil is loam, the fertility is medium, the pH value is 7.1, and the fertilizer and water management are medium during the test period. Another blank control is set, with 4 replicates for each treatment and 30 m for each plot 2, randomized block arrangement in the plot. Using the conventional spraying method, the experiment was carried out at a rate of 50 g of the preparation of the present invention per mu. 40 kg of diammonium hydrogen phosphate was applied per mu as basal fertilizer, and 40 kg of urea was applied as top dressing. Control efficacy of plants (%) = [(1 - number of weed plants before treatment in the control plot × number of weed plants after treatment in the treatment plot) / (number of weed plants after treatment in the control plot × number of weed plants before treatment in the treatment plot)] × 100.

[0059] Table 1 Results of field efficacy test for controlling weeds in corn fields

[0060]

[0061]

[0062] Topramezone·Ametryn·MCPA-sodium is a compound herbicide that combines the herbicidal characteristics of topramezone, ametryn, and MCPA-sodium to improve the control effect on weeds in corn fields. Topramezone is a new type of highly selective benzoylpyrazolone herbicide with characteristics such as high safety, excellent selectivity, broad-spectrum herbicidal activity, long duration of effect, and strong compatibility. It can effectively control annual gramineous and broad-leaved weeds such as Digitaria sanguinalis, Echinochloa crusgalli, Setaria viridis, etc. Ametryn is a selective, systemic pre-emergence and post-emergence herbicide that causes plant death by inhibiting electron transfer in photosynthesis of sensitive plants. It can be adsorbed by the soil to form a drug layer, showing good control effect on newly germinated weeds. MCPA-sodium is a herbicide commonly used to control broad-leaved weeds, with contact activity, and can be quickly absorbed by weeds and cause their death. Combining the characteristics of these components, the powder prepared by the present invention shows broad-spectrum herbicidal activity and fast weeding speed in controlling weeds in corn fields. However, by comparing the example and Control Example 1, it can be found that the addition of modified cellulose can improve the control effect and maintain the herbicidal effect. This may be due to the poor stability of topramezone. Therefore, as time goes by, the drug efficacy weakens. And cellulose, as a stabilizer, can maintain the stability of the preparation in multiple aspects. Therefore, the control effect in Example 1 is better and more persistent. By comparing the example and Control Examples 2-3, it can be found that the control effect of Example 1 is better and more persistent. This may be because neither cellulose nor sodium carboxymethylcellulose can effectively prevent the degradation of topramezone under light. And the modified cellulose in the example is obtained by combining cellulose with functionalized ammonium phosphomolybdate. Ammonium phosphomolybdate is a compound with ultraviolet absorption properties, mainly due to the characteristics of its phosphate group. They usually have a short ultraviolet absorption edge. By introducing Mo into the phosphate 6+Cations cause distortion of the crystal structure, promoting the formation of non-centrosymmetric compounds, and this structure plays a key role in the absorption of ultraviolet light. Metal atoms can form multiple oxidation states, and the electronic transitions between these oxidation states can absorb energy in the ultraviolet region. Therefore, after the modified cellulose is formulated into a solution in the powder, a protective film is formed on the surface of the active ingredient, and its enhanced ultraviolet resistance can protect benzobicyclon from photolysis, thereby enhancing stability. By comparing Example 1 with Examples 2-3, it can be found that the amount of modified cellulose also affects the control effect. Generally speaking, the addition amount in Example 1 is the best.

[0063] Test Example 2

[0064] Take 2.5 mL of the powder solution with a benzobicyclon concentration of 100 mg / L and place it in a 50 mL volumetric flask. Dilute it to the mark with methanol, and ultrasonicate to fully dissolve it. Transfer it to a quartz test tube and perform photolysis analysis under irradiation of a 500 W mercury lamp. Take 5 mL of samples at 0 h, 20 h, 40 h, 50 h, and 70 h, dry them with nitrogen, dilute them to 5 mL with methanol, and measure the content of benzobicyclon. The specific results are shown in Table 2.

[0065] Table 2 Photolytic stability of benzobicyclon in multi-component solid preparations

[0066]

[0067] Light energy can directly or indirectly cause the cleavage of pesticide molecular bonds and ultimately lead to decomposition. Benzobicyclon can undergo decomposition under ultraviolet light irradiation, thereby affecting the herbicidal effect. From the test results in Table 2, it can be seen that compared with the control examples, the photolytic stability of the preparations in the examples is better. This may be because the modified cellulose in the examples is obtained by combining cellulose with functionalized ammonium phosphomolybdate. Ammonium phosphomolybdate is a compound with ultraviolet absorption properties, which mainly benefits from the characteristics of its phosphate groups. They usually have a short ultraviolet absorption edge. By introducing Mo6+ cations into the phosphate, the crystal structure is distorted, promoting the formation of non-centrosymmetric compounds, and this structure plays a key role in the absorption of ultraviolet light. Metal atoms can form multiple oxidation states, and the electronic transitions between these oxidation states can absorb energy in the ultraviolet region. Therefore, after the modified cellulose is formulated into a solution in the powder, a protective film is formed on the surface of the active ingredient, and its enhanced ultraviolet resistance can protect benzobicyclon from photolysis, thereby enhancing stability. In Control Examples 2-3, cellulose or sodium carboxymethylcellulose can only form a high-viscosity environment in aqueous solution, which acts together to reduce the contact between the active ingredient and the external environment and reduce the risk of chemical reactions such as oxidation and hydrolysis, but cannot resist ultraviolet light. Therefore, their effect on improving photolytic stability is not high.

[0068] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation, characterized in that, The following steps are included, by weight parts: S1. Mix 10 - 20 parts of MCPA - Na, 50 - 60 parts of ametryn, 2 - 5 parts of dispersant, 1 - 5 parts of wetting agent, 1 - 2 parts of thickener, 1 - 2 parts of modified cellulose, 0.01 - 1 part of inorganic salt, and 10 - 20 parts of inorganic filler evenly, and then reserve it after air - flow pulverization; S2. Pulverize 5 - 10 parts of isoxaflutole by air - flow and then mix it evenly with the mixture in step S1 to obtain the product.

2. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as described in claim 1, characterized in that, The dispersant is one of lignosulfonate, polycarboxylate, alkylnaphthalenesulfonate, and sodium dodecylbenzenesulfonate.

3. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation according to claim 1, characterized in that, The wetting agent is one of fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether, or sorbitan fatty acid ester polyoxyethylene ether.

4. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as claimed in claim 1, wherein The thickener is one of xanthan gum, sodium polyacrylate, or magnesium aluminum silicate.

5. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as described in claim 1, characterized in that, The inorganic salt is one of ammonium sulfate, ammonium nitrate, or potassium dihydrogen phosphate.

6. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as described in claim 1, wherein The inorganic filler is one of diatomite, montmorillonite, or kaolin.

7. The processing method for preventing the decomposition of topramezone in the multi-component compound solid preparation according to claim 1, characterized in that, The pressure of the air - flow pulverization is 0.3 - 0.5 MPa, and the pulverized particle size is 40 - 50 μm.

8. The processing method for preventing the decomposition of tembotrione in a multiple compound solid preparation according to claim 1, characterized in that, The preparation method of the modified cellulose includes the following steps: X1. Add cellulose into 1 - hexyl - 3 - methylimidazolium chloride, heat to 70 - 80 °C and stir for 1 - 2 h, then add Span 60, epichlorohydrin, and sodium hypophosphite. After adding, cool down to 50 - 60 °C, add toluene and continue to stir for 2 - 3 h, then centrifuge. Remove the supernatant and freeze - dry for the next step; X2. Add lauryl trimethyl ammonium bromide into ethanol, heat to 50 - 60 °C and then add the product of the previous step. Continue to stir for 6 - 10 h, then add ethanol for washing and centrifuge. After removing the supernatant and freeze - drying, add the obtained product into ethanol and mix it evenly with a 10 - 20 wt% ammonium phosphomolybdate solution. Stir evenly and then add it into an autoclave for ion - exchange at 70 - 80 °C for 20 - 30 h. Then centrifuge, discard the supernatant, wash with ethanol, and freeze - dry to obtain the product.

9. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as described in claim 9, characterized in that, The mass ratio of the cellulose to 1 - hexyl - 3 - methylimidazolium chloride, Span 60, epichlorohydrin, and sodium hypophosphite is 3 - 4:100 - 150:2 - 3:2 - 3:0.4 - 1.

10. The processing method for preventing the decomposition of topramezone in a multi-component compound solid preparation as described in claim 9, wherein, The mass ratio of lauryl trimethyl ammonium bromide to the product of the previous step and ammonium phosphomolybdate is 1:1:3 - 5.

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