Method for modifying inorganic powder by using phosphorylcholine copolymer and application of phosphorylcholine copolymer

Abstract

The invention provides a method for modifying inorganic powder by using a phosphorylcholine copolymer. The invention also provides inorganic powder and application thereof in cosmetics. The invention further provides liquid foundation and a preparation method thereof. According to the method for modifying the inorganic powder by using the phosphorylcholine copolymer and the application of the phosphorylcholine copolymer provided by the invention, on the premise of not adding a film-forming agent, on the basis of keeping the dispersibility of the prior art in the application, makeup holding performance which the phosphorylcholine copolymer does not have is obtained, so that cosmetics and sunscreen products can obtain excellent waterproof and sweat-resistant makeup holding performance.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetic raw materials, and relates to a method for modifying inorganic powders with phosphorylcholine copolymers and applications thereof, specifically to a method for modifying inorganic powders (such as titanium dioxide, iron oxide, zinc oxide, etc.) with phosphorylcholine copolymers and application results thereof. Background Art

[0002] Inorganic powders are widely used in cosmetics and are commonly used as colorants, covering agents, sunscreen agents, fillers, and skin feel regulators, etc. Commonly used inorganic powders include titanium dioxide, iron oxide, zinc oxide, mica powder, talc powder, boron nitride, etc. These inorganic powders are widely used in sunscreen cosmetics and color cosmetic products and are usually modified according to different usage requirements during application.

[0003] In the existing technologies in the market, the purpose of powder modification is to change its surface properties and adjust the lipophilic or hydrophilic properties of the powder. According to the required powder dispersion medium, similar modifying materials such as silica, siloxane, amino acids, isopropoxy titanium salts, fluorine, etc. are selected. There are two very important requirements for powders in daily use: dispersibility in the system and makeup holding performance during actual use. The existing technologies mainly focus on improving the dispersibility of powders (such as using silicon treatment, isopropoxy titanium salt treatment, etc.), but the makeup holding performance of these modified powders is poor. There is also the use of fluorine treatment to obtain hydrophobic and oleophobic powders, which have good makeup holding performance, but their dispersibility in the system is poor. Therefore, the existing inorganic powders face the dilemma that it is impossible to have both good dispersibility and makeup holding performance. When preparing color cosmetic products or sunscreen products, a large amount of film-forming agents need to be added to the formula additionally. Since silicon is mostly used for modifying existing powders, organosilicon-based film-forming agents are selected and matched to become the current mainstream choice. However, the use of film-forming agents will increase the risk of formula instability, the consumer experience becomes worse, and the risk of skin irritation is also higher.

[0004] Phosphorylcholine copolymers are a type of polymer material similar to the phospholipid structure. They usually contain amphoteric end groups and alkane non-polar molecular chains. The amphoteric end groups are hydrophilic, and the alkane molecular chains are hydrophobic. This structure is very similar to that of biological membranes. Therefore, the blood compatibility of phosphorylcholine polymers is very close to that of biological membranes. In the field of biomaterials, the research on its properties and synthesis methods has attracted more and more attention. Research shows that phosphorylcholine polymers can modify the surface of biomaterials to mimic the outer structure of cells and are widely used in fields such as medicine and cosmetics. Summary of the Invention

[0005] In view of the deficiencies of the above-mentioned prior art, the purpose of the present invention is to provide a method for modifying inorganic powder with phosphorylcholine copolymer and its application, which takes into account both the dispersion performance and the makeup retention performance, and can achieve waterproof makeup retention without using a film-forming agent, so that the makeup and sunscreen products added with this inorganic powder can obtain makeup retention performance.

[0006] To achieve the above purpose and other related purposes, the first aspect of the present invention provides a method for modifying inorganic powder with phosphorylcholine copolymer, including the following steps:

[0007] 1) Dissolve the phosphorylcholine copolymer in a solvent to obtain a phosphorylcholine copolymer solution;

[0008] 2) Powder and disperse the inorganic powder, filter it, and then add it to water for dispersion and mixing to obtain a slurry;

[0009] 3) Stir the slurry under normal temperature and vacuum conditions, dropwise add the phosphorylcholine copolymer solution, then stir and mix after heating, dry under vacuum, and pulverize and disperse to provide the inorganic powder modified with phosphorylcholine copolymer.

[0010] The second aspect of the present invention provides an inorganic powder obtained by the method for modifying inorganic powder with the above-mentioned phosphorylcholine copolymer.

[0011] The third aspect of the present invention provides the use of the inorganic powder in cosmetics.

[0012] The fourth aspect of the present invention provides a liquid foundation containing the above-mentioned inorganic powder.

[0013] The fifth aspect of the present invention provides a method for preparing a liquid foundation, including the following steps:

[0014] A) Mix the emulsifier, silicone oil, and synthetic oil evenly to obtain a mixed phase;

[0015] B) Add the inorganic powder to the mixed phase for dispersion to obtain an oil phase;

[0016] C) Mix water, humectant, and chelating agent evenly to obtain an aqueous phase;

[0017] D) Heat and keep warm the oil phase and the aqueous phase respectively, pour the aqueous phase into the oil phase for mixing in the first stirring, then carry out the first emulsification reaction in the second stirring, and then add the preservative in the third stirring after cooling by stirring to carry out the second emulsification reaction to provide the required liquid foundation.

[0018] As described above, the method for modifying inorganic powder with phosphorylcholine copolymer and its application provided by the present invention has the following beneficial effects compared with the prior art:

[0019] (1) A method for modifying inorganic powder with phosphorylcholine copolymer and its application provided by the present invention. After modifying the inorganic powder with phosphorylcholine copolymer under specific conditions, it solves the problem that inorganic powders on the current market need to be combined with film-forming agents to enable makeup and sunscreen products to obtain long-lasting makeup performance. Without adding film-forming agents, on the premise of maintaining the dispersibility of the existing technology, it can obtain the long-lasting makeup performance that it does not have, so that makeup and sunscreen products can obtain excellent long-lasting makeup performance.

[0020] (2) A method for modifying inorganic powder with phosphorylcholine copolymer and its application provided by the present invention. After modifying the inorganic powder with phosphorylcholine copolymer, compared with conventional inorganic powder modifiers, the molecular weight of phosphorylcholine copolymer is much larger, which will occupy a larger space position on the surface of the inorganic powder. Due to this "steric hindrance effect" and its surface activity, the dispersibility of the inorganic powder is greatly improved, which is different from inorganic powders with different surface treatments on the current market.

[0021] (3) A method for modifying inorganic powder with phosphorylcholine copolymer and its application provided by the present invention. Due to the structure of phosphorylcholine copolymer similar to that of biological membranes, the long-lasting makeup performance of the inorganic powder on the skin is enhanced, so that in actual formula applications, no film-forming agent needs to be added, it has better stability, the prepared formula has better skin feel, and can obtain very good long-lasting makeup performance of waterproof and sweatproof. Brief Description of the Drawings

[0022] Figure 1 shows the Hegman number of the fineness test in Example 9 of the present invention Figure 1a 、 1b 、1c, where Figure 1a is the inorganic powder sample prepared in Example 1, Figure 1b is the inorganic powder sample prepared in Example 2, Figure 1c is the inorganic powder sample prepared in Example 3.

[0023] Figure 2 shows the hydrophobicity of the inorganic powder in Example 11 of the present invention Figure 2a 、 2b 、2c、2d、2e、2f、2g, where Figure 2a is the inorganic powder sample 2# prepared in Example 2, Figure 2b is the sample prepared in Comparative Example 1, Figure 2c is the sample prepared in Comparative Example 2, Figure 2d is the sample prepared in Comparative Example 3, Figure 2e is the sample prepared in Comparative Example 4, Figure 2f is the sample prepared in Comparative Example 5, Figure 2g is the sample prepared in Comparative Example 6.

[0024] Figure 3 shows the display of the dispersibility of the inorganic powder in Example 11 of the present invention. Figure 3a , 3b , 3c, 3d, 3e, 3f, wherein Figure 3a is the inorganic powder sample 2# prepared in Example 2, Figure 3b is the sample prepared in Comparative Example 1, Figure 3c is the sample prepared in Comparative Example 2, Figure 3d is the sample prepared in Comparative Example 3, Figure 3e is the sample prepared in Comparative Example 4, Figure 3f is the sample prepared in Comparative Example 5.

[0025] Figure 4 Shows the display diagram of oiliness, layering and color bleeding of the liquid foundation sample in Example 13 of the present invention.

[0026] Figure 5 shows the display of the stability of the liquid foundation in Example 13 of the present invention Figure 5a , 5b , 5c, 5d, 5e, 5f, wherein Figure 5a is the liquid foundation sample 1# prepared in Example 8, Figure 5b is the comparative liquid foundation sample 1 prepared in Comparative Example 7, Figure 5c is the comparative liquid foundation sample 2 prepared in Comparative Example 7, Figure 5d is the comparative liquid foundation sample 3 prepared in Comparative Example 7, Figure 5e is the comparative liquid foundation sample 4 prepared in Comparative Example 7, Figure 5f is the comparative liquid foundation sample 5 prepared in Comparative Example 7.

[0027] Figure 6 shows the waterproof and long-lasting makeup display of the application of the liquid foundation in Example 14 of the present invention Figure 6a , 6b , wherein Figure 6a is the liquid foundation sample 1# prepared in Example 8 and the comparative liquid foundation samples 1 and 4 prepared in Comparative Example 7, Figure 6b is the comparative liquid foundation samples 2, 3 and 5 prepared in Comparative Example 7.

[0028] Figure 7 shows the display of the process before and after the waterproof and long-lasting makeup application of Example 15 of the present invention and the commercially available benchmark competitor Figure 7a , 7b , 7c, wherein Figure 7a is the comparison diagram of the application stage, Figure 7b is the comparison diagram of the water droplet state after water flushing, Figure 7c is the comparison diagram of the tissue stained with the sample. Detailed implementation mode

[0029] The inventors of the present application have developed a method for modifying inorganic powder with phosphorylcholine copolymer. Inorganic powder obtained by the above method is also provided. Further provided is the use of inorganic powder modified with phosphorylcholine copolymer in cosmetics. Further provided is a cosmetic containing inorganic powder modified with phosphorylcholine copolymer, such as a liquid foundation. During its actual application, very good makeup holding performance of waterproof and sweatproof can be obtained without adding a film-forming agent. Thus, the present invention is completed and will be specifically described as follows.

[0030] Term Definition

[0031] Unless otherwise specified, the following words, phrases and symbols used in this specification generally have the meanings described below.

[0032] Generally, the nomenclature used herein (e.g., IUPAC nomenclature) and the laboratory procedures described below (including those for cell culture, organic chemistry, analytical chemistry, pharmacology, etc.) are those well known and commonly used in the art. Unless otherwise defined, all scientific and technical terms used herein in connection with the present disclosure described herein have the same meaning as commonly understood by those skilled in the art. Additionally, in the claims and / or the specification, when the term "a" or "an" is used in conjunction with the term "comprising" or a noun, its meaning may be "one", but is also consistent with the meanings of "one or more", "at least one" and "one or more than one". Similarly, the term "another" or "other" may mean at least a second or more.

[0033] It should be understood that whenever an aspect is described herein using the term "comprising" or "including", other similar aspects described by "consisting of" and / or "consisting essentially of" are also provided.

[0034] The first aspect of the present invention provides a method for modifying inorganic powder with phosphorylcholine copolymer, comprising the following steps:

[0035] 1) Dissolve the phosphorylcholine copolymer in a solvent to obtain a phosphorylcholine copolymer solution;

[0036] 2) Pulverize and disperse the inorganic powder, filter it, and then add it to water for dispersion and mixing to obtain a slurry;

[0037] 3) Stir the slurry under normal temperature and vacuum conditions, dropwise add the phosphorylcholine copolymer solution, then stir and mix after heating, vacuum dry, pulverize and disperse to provide inorganic powder modified with phosphorylcholine copolymer.

[0038] In the above step 1), the chemical structure of the phosphorylcholine copolymer (i.e., phosphorylcholine polymer - MBH) is shown in formula (I):

[0039]

[0040] In formula (I), x > 0; z > 0; y ≥ 0; 0 ≤ m ≤ 25; R is selected from H, (CH2) n OH, (CH2) n CHOCH2 or (CH2) n NH2, where 0 ≤ n ≤ 8.

[0041] In reaction formula (I), x, y, and z respectively represent the number of repeating units. x is a positive integer greater than 0, z is a positive integer greater than 0, and y is an integer greater than or equal to 0.

[0042] For example, x can be 500 - 1000. In some specific embodiments, x can be 500 - 600, 500 - 700, 500 - 900, 900 - 1000.

[0043] For example, y can be 0 - 300. In some specific embodiments, y can be 0 - 100, 0 - 200, 0 - 300.

[0044] For example, z can be 50 - 500. In some specific embodiments, z can be 50 - 100, 100 - 200, 200 - 500.

[0045] In reaction formula (I), x:y:z is 5 - 10:0 - 3:0.5 - 5. In some specific embodiments, x:y:z can be 5 - 8:0 - 3:0.5 - 5, 8 - 10:0 - 3:0.5 - 5, 5 - 10:0 - 1:0.5 - 5, 5 - 10:2 - 3:0.5 - 5, 5 - 10:0 - 3:0.5 - 2, 5 - 10:0 - 3:2 - 5.

[0046] In reaction formula (I), m is a positive integer greater than or equal to 0 and less than or equal to 25. For example, 1 ≤ m ≤ 5, 5 ≤ m ≤ 10, 2 ≤ m ≤ 9, 3 ≤ m ≤ 8, 4 ≤ m ≤ 7, 15 ≤ m ≤ 25. In some specific embodiments, m can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25.

[0047] In reaction formula (I), n is an integer greater than or equal to 0 and less than or equal to 8. For example, 0 ≤ n ≤ 4, 4 ≤ n ≤ 8, 1 ≤ n ≤ 7, 2 ≤ n ≤ 6, 3 ≤ n ≤ 5, 4 ≤ n ≤ 6, 3 ≤ n ≤ 7, 2 ≤ n ≤ 8. In some specific embodiments, n can be 0, 1, 2, 3, 4, 5, 6, 7, 8.

[0048] Specifically, the above-mentioned phosphorylcholine copolymer is a raw material produced by Ori Company. In 2023, it obtained a new INCI name: BUTYL METHACRYLATE / HEMA / METHACRYLOXYETHYL PHOSPHORYLCHOLINE COPOLYMER through PCPC, and obtained a new Chinese INCI name for the raw material: Phosphorylcholine Polymer - MBH through the record-filing of the drug regulatory agency, thus obtaining an innovative ternary copolymerized phosphorylcholine.

[0049] In the above step 1), the solvent is selected from one or a combination of water, ethanol, isopropanol, butanediol, isododecane (CAS No. 31807 - 55 - 3), polydimethylsiloxane (CAS No. 9006 - 65 - 9), or an oil-in-water emulsifier.

[0050] In a specific embodiment, the oil-in-water emulsifier is a polyglycerol-based emulsifier.

[0051] In a further preferred embodiment, the oil-in-water emulsifier is selected from at least one of polysorbate - 20, polysorbate - 40, polysorbate - 80, PEG - 60 hydrogenated castor oil (CAS No. 61788 - 85 - 0), PEG - 6 caprylic / capric glycerides (CAS No. 52504 - 24 - 2), laureth - 4, laureth - 23, ceteth - 20, cetearyl alcohol polyether - 25, steareth - 10, and steareth - 21.

[0052] In the above step 1), the mass ratio of the phosphorylcholine copolymer to the solvent added is 1:1 - 30, specifically such as 1:1 - 5, 1:5 - 15, 1:15 - 30, preferably 1:5 - 15, more preferably 1:8 - 12, and further preferably 1:10.

[0053] In the above step 2), the inorganic powder is selected from at least one of titanium dioxide, iron oxide, zinc oxide, mica powder, talc powder, boron nitride, pearl powder, kaolin, chromium(III) oxide (chrome green), ultramarine, calamine, zinc carbonate, and bismuth oxychloride.

[0054] In a specific embodiment, the inorganic powder is selected from at least one of titanium dioxide or iron oxide.

[0055] In the above step 2), the number of times of powdering and dispersing is not less than 5 times, preferably 5 - 10 times, and more preferably 5 times.

[0056] In a specific embodiment, the time for each powdering and dispersing is 25 - 35 s, preferably 30 s.

[0057] In the above step 2), the equipment for powdering and dispersing treatment is selected from at least one of a high-speed powdering pot, a multi-functional pulverizer, a wall breaker or a hammer pulverizer. The high-speed powdering pot, the multi-functional pulverizer, the wall breaker or the hammer pulverizer are all commonly used pulverizing equipment.

[0058] In a specific embodiment, the equipment for powdering and dispersing treatment is a multi-functional pulverizer. The multi-functional pulverizer can select a high-speed rotation speed for powdering and dispersing.

[0059] In the above step 2), the filtration is screen filtration.

[0060] In a specific embodiment, the aperture of the screen mesh for screen filtration is 10 - 60 μm, specifically such as 10 - 20 μm, 20 - 50 μm, 50 - 60 μm, and preferably 20 - 50 μm.

[0061] In the above step 2), the mass ratio of the filtered inorganic powder to water is 1:0.1 - 5, specifically such as 1:0.1 - 1, 1:1 - 3, 1:3 - 5, preferably 1:1 - 3, and more preferably 1:2.

[0062] In the above step 2), the potential of the slurry needs to be adjusted, and the potential of the slurry is adjusted to zero.

[0063] In a specific embodiment, a ZETA potentiometer or a pH meter is used to adjust the potential of the slurry, and preferably a ZETA potentiometer. The ZETA potentiometer or the pH meter is a commonly used ZETA potentiometer or pH meter.

[0064] In the above step 3), the slurry is stirred in a reaction kettle.

[0065] In the above step 3), the normal temperature is 20 - 30 °C.

[0066] In the above step 3), the vacuum degree of the vacuum state is -0.3 to -0.1 Mpa, preferably -0.2 Mpa.

[0067] In the above step 3), the mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry added is 0.001 - 3:100, specifically such as 0.001 - 0.01:100, 0.01 - 0.1:100, 0.1 - 1:100, 1 - 3:100, preferably 0.1 - 1:100, and more preferably 0.1 - 0.5:100. Enabling the phosphorylcholine copolymer to modify the inorganic powder can obtain makeup-holding performance.

[0068] In the above step 3), the heating temperature is 20 - 120°C, specifically such as 20 - 50°C, 50 - 70°C, 70 - 120°C, and preferably 50 - 70°C.

[0069] In the above step 3), the stirring and mixing time is 0.1 - 3 hours, specifically such as 0.1 - 0.5 hours, 0.5 - 2 hours, 2 - 3 hours, and preferably 0.5 - 2 hours.

[0070] In the above step 3), the vacuum drying temperature is 40 - 120°C, specifically such as 40 - 60°C, 60 - 90°C, 90 - 120°C, preferably 60 - 90°C, and more preferably 70 - 80°C.

[0071] In the above step 3), the vacuum degree of vacuum drying is -1 Mpa to -0.1 Mpa, specifically such as -1 Mpa to -0.9 Mpa, -0.9 Mpa to -0.4 Mpa, -0.4 Mpa to -0.1 Mpa, and preferably -0.9 Mpa to -0.4 Mpa.

[0072] In the above step 3), the vacuum drying time is 0.1 - 5 hours, specifically such as 0.1 - 0.5 hours, 0.5 - 2 hours, 2 - 4 hours, 4 - 5 hours, and preferably 2 - 4 hours.

[0073] In the above step 3), the equipment for pulverizing and dispersing is a jet mill. The jet mill is a commonly used jet mill.

[0074] The second aspect of the present invention provides an inorganic powder, which is obtained by the modification method of the inorganic powder with the above-mentioned phosphorylcholine copolymer.

[0075] The third aspect of the present invention provides a use of an inorganic powder in cosmetics.

[0076] In the above use, the cosmetic is a liquid foundation.

[0077] The fourth aspect of the present invention provides a liquid foundation, which contains the above-mentioned inorganic powder.

[0078] In the above liquid foundation, by weight percentage, the liquid foundation includes the following components:

[0079] Emulsifier 1 - 5%; specifically such as 1 - 3%, 3 - 4%, 4 - 5%, and preferably 3 - 4%;

[0080] Silicone oil 10 - 25%; specifically such as 10 - 15%, 15 - 20%, 20 - 25%, and preferably 15 - 20%;

[0081] Synthetic grease: 8-16%; specifically 8-10%, 10-14%, 14-16%, preferably 10-14%;

[0082] Inorganic powder: 3-21%; specifically 3-10%, 10-15%, 15-21%, preferably 10-15%;

[0083] Humectant: 2-15%; specifically 2-8%, 8-10%, 10-15%, preferably 8-10%;

[0084] Chelating agent: 0.1-1%; specifically 0.1-0.2%, 0.2-0.4%, 0.4-1%, preferably 0.2-0.4%;

[0085] Preservative: 0.3-2%; specifically 0.3-0.6%, 0.6-1%, 1-2%, preferably 0.6-1%;

[0086] The balance is water.

[0087] In a specific embodiment, the liquid foundation comprises the following components by weight percentage:

[0088] Emulsifier: 3.5%;

[0089] Silicone oil: 16.5%;

[0090] Synthetic grease: 12%;

[0091] Inorganic powder: 12%;

[0092] Humectant: 9%;

[0093] Chelating agent: 0.3%;

[0094] Preservative: 0.7%;

[0095] Water: 46%.

[0096] In a specific embodiment, the emulsifier is selected from at least one of polyglycerol esters, sorbitan fatty acid ester series, sorbitan cocoate (PEG-20 sorbitan cocoate), sucrose fatty acid ester, alkyl glycosides, hydrogenated lecithin, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, fatty acid polyoxyethylene ester, polyethers, glycerol caprylate / caprate.

[0097] In a further preferred embodiment, the polyglycerol esters are selected from at least one of polysorbate-20, polysorbate-40, polysorbate-80, PEG-60 hydrogenated castor oil (CAS No. 61788-85-0), PEG-6 caprylic / capric glycerides (CAS No. 127281-18-9), laureth-4, laureth-23, ceteth-20, cetearyl ethoxylate-25, steareth-10, and steareth-21.

[0098] In a further preferred embodiment, the sorbitan fatty acid ester series includes: sorbitan monolaurate (Span-20, HLB = 8.6), sorbitan monopalmitate (Span-40, HLB = 6.7), sorbitan monostearate (Span-60, HLB = 4.7), sorbitan tristearate (Span-65, HLB = 2.1), sorbitan monooleate (Span-80, HLB = 4.3), and sorbitan trioleate (Span-85, HLB = 1.8).

[0099] In a further preferred embodiment, the alkyl polyglycosides refer to alkyl polyglucosides (Alkyl Polyglucoside, abbreviated as APG) synthesized from glucose and fatty alcohols, which are glycosides with the number of sugar units greater than or equal to 2 in complex glycoside compounds, collectively referred to as alkyl polysaccharides (or alkyl polyglycosides). Generally, the degree of polymerization n of alkyl polyglycosides ranges from 1.1 to 3, and R is an alkyl group with C8 - C16.

[0100] In a further preferred embodiment, the fatty alcohol polyoxyethylene ether (AEO), also known as polyoxyethylene fatty alcohol ether, is an ether formed by the condensation of polyethylene glycol (PEG) and fatty alcohol, represented by the following general formula: RO(CH2CH2O)nH, where n is the degree of polymerization.

[0101] In a further preferred embodiment, the alkylphenol polyoxyethylene ether (APEO) includes 80 - 85% nonylphenol polyoxyethylene ether (NPEO), more than 15% octylphenol polyoxyethylene ether (OPEO), and 1% each of dodecylphenol polyoxyethylene ether (DPEO) and dinonylphenol polyoxyethylene ether (DNPEO).

[0102] In a further preferred embodiment, the polyethers are selected from at least one of steareth-2, oleth-2, oleth-3, and oleth-5.

[0103] In a further preferred embodiment, the glyceryl caprylate / caprate is selected from at least one of PEG-6 caprylate / caprate glyceryl esters (CAS No. 52504-24-2), PEG-7 caprylate / caprate glyceryl esters (CBNumber: CB9962804), and polyglyceryl-10 caprylate / caprate glyceryl esters (CAS No. 51033-41-1).

[0104] In a specific embodiment, the silicone oil is selected from at least one of cyclopentasiloxane (CAS No. 541-02-6), polydimethylsiloxane (CAS No. 9006-65-9), and phenyltrimethylsiloxane (CAS No. 73559-47-4).

[0105] In a specific embodiment, the synthetic oil and fat is selected from at least one of isotridecyl isononanoate, tridecyl trimellitate, glyceryl caprylate / caprate, tocopheryl acetate, isononyl isononanoate, isodecyl neopentanoate, squalane, jojoba oil, and ethylhexyl methoxycinnamate.

[0106] In a specific embodiment, the humectant is selected from at least one of glycerol, butanediol, propylene glycol, polyethylene glycol, polysaccharide, panthenol, and sodium hyaluronate.

[0107] In a further preferred embodiment, the polysaccharide is a polymer carbohydrate composed of sugar chains linked by glycosidic bonds and consisting of at least more than 10 monosaccharides, and can be represented by the general formula (C6H 10 O5)n.

[0108] In a specific embodiment, the chelating agent is selected from at least one of disodium ethylenediaminetetraacetate (EDTA-2Na), sodium chloride, and magnesium sulfate heptahydrate.

[0109] In a specific embodiment, the preservative is selected from at least one of caprylyl glycol, phenoxyethanol, ethylhexylglycerin, hexylene glycol, and pentylene glycol.

[0110] In a specific embodiment, the water is deionized water.

[0111] The fifth aspect of the present invention provides a method for preparing a liquid foundation, comprising the following steps:

[0112] A) Mix the emulsifier, silicone oil, and synthetic oil and fat evenly to obtain a mixed phase;

[0113] B) Add the inorganic powder to the mixed phase for dispersion to obtain an oil phase;

[0114] C) Mix the water, humectant, and chelating agent evenly to obtain an aqueous phase;

[0115] D) Heat the oil phase and the water phase separately and keep them at a constant temperature. Pour the water phase into the oil phase during the first stirring for mixing, then conduct the first emulsification reaction during the second stirring. After that, cool the mixture while stirring and add a preservative during the third stirring for the second emulsification reaction to provide the desired liquid foundation.

[0116] In the above step A), the mixing is carried out using an IKA blender.

[0117] In the above step A), the stirring speed of the mixing is 800 - 1200 rpm, preferably 1000 rpm.

[0118] In the above step A), the stirring time of the mixing is 8 - 12 min, preferably 10 min.

[0119] In the above step B), the dispersion is carried out using a Primix high - speed dispersion device.

[0120] In the above step B), the dispersion time is not less than 20 min, preferably 20 - 30 min, more preferably 20 min.

[0121] In the above step B), the stirring speed of the dispersion is 1300 - 1500 rpm, preferably 1400 rpm.

[0122] In the above step C), the water is deionized water.

[0123] In the above step C), the mixing is carried out using an IKA blender.

[0124] In the above step C), the stirring speed of the mixing is 600 - 1800 rpm, preferably 800 rpm.

[0125] In the above step C), the stirring time of the mixing is 14 - 16 min, preferably 15 min.

[0126] In the above step D), the heating temperature is 80 - 90 °C, specifically such as 80 - 85 °C, 85 - 90 °C, 84 - 86 °C, preferably 85 °C.

[0127] In the above step D), the holding time is 25 - 35 min, specifically such as 25 - 30 min, 30 - 35 min, 28 - 32 min, preferably 30 min.

[0128] In the above step D), the first stirring, the second stirring and the third stirring are carried out using a Primix high - speed homogenization device.

[0129] In the above step D), the stirring rate of the first stirring is 1500 - 2500 rpm, specifically such as 1500 - 2000 rpm, 2000 - 2500 rpm, 1800 - 2200 rpm, and preferably 2000 rpm.

[0130] In the above step D), the time of the first stirring is 4 - 6 min, and preferably 5 min.

[0131] In the above step D), the stirring rate of the second stirring is 3500 - 4500 rpm, specifically such as 3500 - 4000 rpm, 4000 - 4500 rpm, 3800 - 4200 rpm, and preferably 4000 rpm.

[0132] In the above step D), the time of the second stirring is not less than 5 min, specifically such as 5 - 10 min, and preferably 5 min.

[0133] In the above step D), the stirring and cooling is carried out using an IKA mixer.

[0134] In the above step D), the stirring and cooling is carried out until the temperature reaches 35 - 45 °C, specifically such as 35 - 40 °C, 40 - 45 °C, 38 - 42 °C, and preferably 40 °C.

[0135] In the above step D), the stirring rate of the stirring and cooling is 40 - 60 rpm, and preferably 50 rpm.

[0136] In the above step D), the stirring rate of the third stirring is 1500 - 2500 rpm, specifically such as 1500 - 2000 rpm, 2000 - 2500 rpm, 1800 - 2200 rpm, and preferably 2000 rpm.

[0137] In the above step D), the time of the third stirring is not less than 2 min, specifically such as 2 - 5 min, and preferably 2 min.

[0138] The above IKA mixer is an electric mixer commonly used. The above Primix high-speed dispersion equipment is a Primix high-speed stirring and dispersing machine commonly used. The above Primix high-speed homogenization equipment is a Primix high-speed homogenizer commonly used.

[0139] The following illustrates the embodiments of the present invention through specific specific examples. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0140] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as commonly understood by those skilled in the art of this technology. In addition to the specific methods, equipment, and materials used in the embodiments, according to the knowledge of the prior art by those skilled in the art of this technology and the description of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to those described in the embodiments of the present invention can also be used to implement the present invention.

[0141] Example 1

[0142] Dissolve the phosphorylcholine copolymer-MBH in ethanol, with the mass ratio of the phosphorylcholine copolymer to ethanol being 1:3, to obtain a phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 700, y is 200, z is 200, m is 10, and R is H.

[0143] Use a high-speed powder mixer to powder and disperse titanium dioxide, which is an inorganic powder, 5 times, each time for 30 s. After that, filter through a sieve with a pore size of 35 μm, and then add it to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:0.5 to obtain a slurry. Adjust the potential of the slurry to zero with a pH meter.

[0144] Then, add the slurry to a reaction kettle. At room temperature, stir in a vacuum state of -0.2 Mpa, and slowly dropwise add the phosphorylcholine copolymer solution. The mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry added is 0.1:100. After the dropwise addition is completed, heat to 30 °C and stir and mix for 2 hours. Then, vacuum-dry the slurry at a temperature of 50 °C, a vacuum degree of -0.6 Mpa, and a drying time of 2 hours. Finally, pulverize and disperse the dried powder with a jet mill to obtain the inorganic powder sample 1# modified with the phosphorylcholine copolymer.

[0145] Example 2

[0146] Dissolve the phosphorylcholine copolymer-MBH in ethanol, with the mass ratio of the phosphorylcholine copolymer to ethanol being 1:10, to obtain a phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 750, y is 150, z is 300, m is 15, and R is (CH2) n OH, and n is 4.

[0147] The iron oxide, which is an inorganic powder, is pulverized and dispersed 5 times using a multi-functional pulverizer for 30 s each time. After that, it is filtered through a sieve with a pore size of 40 μm and then added to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:2 to obtain a slurry. The potential of the slurry is adjusted to zero using a ZETA potentiometer.

[0148] Then, the slurry is added to a reaction kettle. At room temperature, it is stirred under a vacuum stirring state of -0.2 Mpa, and a phosphocholine copolymer solution is slowly added dropwise. The mass ratio of the phosphocholine copolymer in the phosphocholine copolymer solution to the inorganic powder in the slurry added is 0.3:100. After the dropwise addition is completed, it is heated to 60 °C and stirred and mixed for 1 hour. Then, the slurry is dried under vacuum at a temperature of 75 °C, a vacuum degree of -0.8 Mpa, and a drying time of 3 hours. Finally, the dried powder is pulverized and dispersed using a jet mill to obtain an inorganic powder sample 2# modified with a phosphocholine copolymer.

[0149] Example 3

[0150] The phosphocholine copolymer-MBH is dissolved in ethanol, and the mass ratio of the phosphocholine copolymer to ethanol is 1:20 to obtain a phosphocholine copolymer solution. In the phosphocholine copolymer-MBH shown in formula (I), x is 800, y is 100, z is 400, m is 20, R is (CH2) n CHOCH2, and n is 6.

[0151] The zinc oxide, which is an inorganic powder, is pulverized and dispersed 5 times using a wall breaker for 30 s each time. After that, it is filtered through a sieve with a pore size of 30 μm and then added to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:4 to obtain a slurry. The potential of the slurry is adjusted to zero using a ZETA potentiometer.

[0152] Then, the slurry is added to a reaction kettle. At room temperature, it is stirred under a vacuum stirring state of -0.2 Mpa, and a phosphocholine copolymer solution is slowly added dropwise. The mass ratio of the phosphocholine copolymer in the phosphocholine copolymer solution to the inorganic powder in the slurry added is 0.5:100. After the dropwise addition is completed, it is heated to 100 °C and stirred and mixed for 0.5 hour. Then, the slurry is dried under vacuum at a temperature of 105 °C, a vacuum degree of -0.4 Mpa, and a drying time of 0.5 hour. Finally, the dried powder is pulverized and dispersed using a jet mill to obtain an inorganic powder sample 3# modified with a phosphocholine copolymer.

[0153] Example 4

[0154] Dissolve the phosphorylcholine copolymer-MBH in water at a mass ratio of the phosphorylcholine copolymer to water of 1:5 to obtain a phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 500, y is 300, z is 50, m is 1, R is (CH2) n NH2, and n is 8.

[0155] Use a hammer mill to pulverize and disperse mica powder, which is an inorganic powder, 7 times for 25 s each time, then filter through a 20-μm aperture sieve, and then add it to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:1 to obtain a slurry. Adjust the potential of the slurry to zero with a pH meter.

[0156] Then, add the slurry to a reaction kettle, and under normal temperature, stir in a vacuum stirring state at -0.3 Mpa, and slowly dropwise add the phosphorylcholine copolymer solution. The mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry added is 0.001:100. After the dropping is completed, heat to 40 °C and stir and mix for 3 hours. Then, vacuum dry the slurry at a temperature of 60 °C, a vacuum degree of -0.9 Mpa, and a drying time of 0.5 hours. Finally, pulverize and disperse the dried powder with a jet mill to obtain the inorganic powder sample 4# modified with the phosphorylcholine copolymer.

[0157] Example 5

[0158] Dissolve the phosphorylcholine copolymer-MBH in isododecane at a mass ratio of the phosphorylcholine copolymer to isododecane of 1:15 to obtain a phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 1000, y is 0, z is 500, m is 0, R is (CH2) n OH, and n is 2.

[0159] Use a wall breaker to pulverize and disperse boron nitride, which is an inorganic powder, 6 times for 28 s each time, then filter through a 50-μm aperture sieve, and then add it to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:3 to obtain a slurry. Adjust the potential of the slurry to zero with a pH meter.

[0160] Then, the slurry is added to the reaction kettle. At room temperature, it is stirred under a vacuum of -0.1 Mpa, and the phosphorylcholine copolymer solution is slowly added dropwise. The mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry is 3:100. After the dropwise addition is completed, it is heated to 100 °C and stirred and mixed for 0.5 hours. Then, the slurry is dried under vacuum at a temperature of 100 °C, a vacuum degree of -0.3 Mpa, and a drying time of 2 hours. Finally, the dried powder is pulverized and dispersed by a jet mill to obtain the inorganic powder sample 5# modified with the phosphorylcholine copolymer.

[0161] Example 6

[0162] Dissolve the phosphorylcholine copolymer-MBH in polydimethylsiloxane. The mass ratio of the phosphorylcholine copolymer to polydimethylsiloxane is 1:12 to obtain the phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 600, y is 50, z is 100, m is 25, R is (CH2) n CHOCH2, and n is 0.

[0163] The boron nitride as the inorganic powder is pulverized and dispersed 5 times with a high-speed powder mill for 28 s each time, then filtered through a 30-μm aperture sieve, and then added to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:0.5 to obtain the slurry. The potential of the slurry is adjusted to zero by a pH meter.

[0164] Then, the slurry is added to the reaction kettle. At room temperature, it is stirred under a vacuum of -0.15 Mpa, and the phosphorylcholine copolymer solution is slowly added dropwise. The mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry is 2:100. After the dropwise addition is completed, it is heated to 80 °C and stirred and mixed for 1 hour. Then, the slurry is dried under vacuum at a temperature of 90 °C, a vacuum degree of -0.2 Mpa, and a drying time of 4 hours. Finally, the dried powder is pulverized and dispersed by a jet mill to obtain the inorganic powder sample 6# modified with the phosphorylcholine copolymer.

[0165] Example 7

[0166] Dissolve the phosphorylcholine copolymer-MBH in polysorbate-20. The mass ratio of the phosphorylcholine copolymer to polysorbate-20 is 1:8 to obtain the phosphorylcholine copolymer solution. In the phosphorylcholine copolymer-MBH shown in formula (I), x is 900, y is 250, z is 350, m is 5, and R is H.

[0167] The zinc carbonate, which is an inorganic powder, is pulverized and dispersed 8 times using a multi-functional pulverizer for 25 seconds each time. After that, it is filtered through a sieve with a pore size of 55 μm and then added to water for dispersion and mixing. The mass ratio of the filtered inorganic powder to water is 1:2.5 to obtain a slurry. The potential of the slurry is adjusted to zero using a pH meter.

[0168] Then, the slurry is added to a reaction kettle. At room temperature, it is stirred under a vacuum stirring state of -0.25 Mpa, and a phosphocholine copolymer solution is slowly added dropwise. The mass ratio of the phosphocholine copolymer in the phosphocholine copolymer solution to the inorganic powder in the slurry is 1:100. After the dropwise addition is completed, it is heated to 50 °C and stirred and mixed for 2.5 hours. Then, the slurry is dried under vacuum at a temperature of 70 °C and a vacuum degree of -0.8 Mpa for 2 hours. Finally, the dried powder is pulverized and dispersed using a jet mill to obtain the inorganic powder sample 7# modified with a phosphocholine copolymer.

[0169] Example 8

[0170] The dried weight loss test is carried out on the slurry after vacuum drying in the preparation processes of Examples 1-3.

[0171] The method for the dried weight loss test is as follows: Open the stopper of the weighing bottle, place it in an oven at (105 ± 2) °C and heat for 2 h, then put it in a desiccator to cool, cover the stopper, and weigh the mass w0 of the weighing bottle, accurate to 1 mg. Uniformly spread (2 ± 0.2) g of the sample at the bottom of the weighing bottle, cover the stopper, and weigh the mass w1 of the weighing bottle and the sample before baking, accurate to 1 mg. Remove the stopper, place the weighing bottle and the sample in an oven at (105 ± 2) °C and heat for at least 3 h, then cool in a desiccator, cover the stopper, and weigh the mass w2 of the bottle and the sample after baking, accurate to 1 mg. The dried weight loss x1 (%) is calculated according to the following formula:

[0172]

[0173] In the formula:

[0174] w0 is the mass of the weighing bottle, in grams (g);

[0175] w1 is the mass of the weighing bottle and the sample before baking, in grams (g);

[0176] w2 is the mass of the weighing bottle and the sample after baking, in grams (g).

[0177] The specific test results are shown in Table 1 below. As can be seen from Table 1, the smaller the drying loss data result, the smaller the solvent residue in the powder. The drying loss needs to reach ≤0.5% to meet the requirements for later use. According to the results, it can be found that the drying temperature of Example 1 is too low to meet the requirements; the drying processes of Example 2 and Example 3 meet the requirements and can be selected according to the actual production situation.

[0178] Table 1

[0179] Sample Loss on drying Example 1 0.74％ Example 2 0.05％ Example 3 0.03％

[0180] Example 9

[0181] The inorganic powder after pulverization and dispersion in the preparation processes of Examples 1 - 3 was subjected to fineness testing.

[0182] The method for fineness testing is as follows: 75.0 g of the above - mentioned inorganic powder and 105.0 g of 10 cs silicone oil were fully mixed under high - speed dispersion to prepare 41.7% slurry A, and the dispersion conditions were: 4000 rpm, 40 min. Then, 12.0 g of slurry A was taken out, and 21.3 g of 10 cs silicone oil was added and fully mixed under high - speed dispersion to prepare 15% slurry B, and the dispersion conditions were 1600 rpm, 10 min. 3 drops of the dispersed slurry B were dropped with a dropper onto a draw - down bar fineness gauge, and a film was formed with a draw - down bar, and the test results were read. The average value was taken for 3 film - forming operations. The use of the fineness gauge was operated according to "GB / T 1724 - 2019 Determination of the fineness of grinding of paints, varnishes and printing inks".

[0183] The specific test results are shown in Table 2 below and Figure 1a 、 1b 、1c. As can be seen from Table 2 and Figure 1a 、 1b 、1c, the fineness test is an important index reflecting the dispersion performance of the powder in the medium. The larger the Hegman number result, the better the dispersion of the powder. As a powder used in cosmetics, its fineness will greatly affect the skin feel of the final product. Therefore, it is required that the fineness of the modified powder needs to be greater than 5.5 Hegman numbers. From the test results, it can be seen that there were particle scratches at 4.0 Hegman numbers in Example 1, and the number of particles was relatively large; the overall film scraping of Example 2 was very uniform, and there was a slight particle scratch at 7.0 Hegman numbers; there were particle scratches at 5.5 Hegman numbers in Example 3, and the number of particles was slightly more than that in Example 2. Therefore, the fineness performance of Example 2 is the best.

[0184] Table 2

[0185] Sample Fineness Example 1 4.0 Hegman number Example 2 7.0 Hegman number Example 3 5.5 Hegman number

[0186] Example 10

[0187] To measure the oil absorption of inorganic powders, 10 g of inorganic powder samples 1# - 3# prepared in Examples 1 - 3 were weighed separately and placed on a high-hardness glass plate. Linseed oil was weighed by the precision balance subtraction method. The sample and linseed oil were fully rolled and mixed with a spatula, and the test oil was added dropwise as needed during rolling until there was no excess free powder and no excess oil, which was the test end point. The weight of the test oil used was recorded and converted to the unit: g / 100 g.

[0188] The specific test results are shown in Table 3 below. As can be seen from Table 3, the oil absorption reflects the integrity of the modification of inorganic powders and the dispersion performance of inorganic powders indirectly. The lower the oil absorption, the more complete the coating of the inorganic powder and the better the dispersion. The oil absorption of Example 2 is lower than that of the other two examples. At the same time, this data result is also consistent with the fineness result.

[0189] Table 3

[0190] Sample Oil absorption Example 1 19.06 g / 100 g Example 2 15.34 g / 100 g Example 3 17.24 g / 100 g

[0191] Comparative Example 1

[0192] Directly purchase commercially available benchmark powder competitors, specifically inorganic powder samples modified with triethoxyoctylsilane.

[0193] Comparative Example 2

[0194] Directly purchase commercially available benchmark powder competitors, specifically inorganic powder samples modified with sodium stearoyl glutamate.

[0195] Comparative Example 3

[0196] Directly purchase commercially available benchmark powder competitors, specifically inorganic powder samples modified with isopropyl triisostearoyl titanate.

[0197] Comparative Example 4

[0198] Directly purchase commercially available benchmark powder competitors, specifically inorganic powder samples modified with perfluorooctyltriethoxysilane.

[0199] Comparative Example 5

[0200] Directly purchase commercially available benchmark powder competitors, specifically inorganic powder samples modified with hydrogenated lecithin.

[0201] Comparative Example 6

[0202] Disperse 99.7 parts by mass of crude titanium dioxide, and then premix it with 0.15% wt (based on the mass of titanium dioxide) of a dispersant: sodium hexametaphosphate, stir evenly to obtain a titanium dioxide dispersion slurry. Dissolve 0.3 parts by mass of a phosphorylcholine polymer: polyquaternium-51 in a solvent prepared according to a mass ratio of water, ethanol, and isopropyl alcohol of 1:1:0.2. Add it to the titanium dioxide dispersion slurry under ultra-high-speed stirring through a constant flow pump, and continuously stir to obtain a first slurry. Wash and filter the first slurry, dry and crush the filter cake to obtain phosphorylcholine polymer-modified titanium dioxide, which is the phosphorylcholine polymer-modified inorganic powder sample.

[0203] Example 11

[0204] Compare and test the physical and chemical indexes of the inorganic powder sample 2# prepared in Example 2 with the samples prepared in Comparative Examples 1-6.

[0205] (1) Hydrophobicity of inorganic powder:

[0206] Take 10 g of the inorganic powder sample 2# of Example 2 and the samples prepared in Comparative Examples 1-6. After mixing them evenly with 1 g of magnesium stearate respectively, use a powder press to press the powder into a powder cake. Drop a drop of water on the surface of the powder cake with a dropper, and use a powder contact angle measuring instrument to measure the contact angle of the water droplet on the powder surface.

[0207] The specific test results are shown in Table 4 below and Figure 2a 、 2b 、2c, 2d, 2e, 2f, 2g. From Table 4 and Figure 2a 、 2b 、2c, 2d, 2e, 2f, 2g, it can be seen that the larger the contact angle, the more hydrophobic the powder is and the better the waterproof ability. Through testing, the contact angle of Example 2 is much larger than that of Comparative Examples 1-6.

[0208] Table 4

[0209] Sample Contact angle Example 2 152.99° Comparative Example 1 143.50° Comparative Example 2 141.577° Comparative Example 3 142.05° Comparative Example 4 146.261° Comparative Example 5 137.002° Comparative Example 6 143.09°

[0210] (2) Oil absorption of inorganic powder

[0211] Take 10 g of the inorganic powder sample 2# of Example 2 and the samples prepared in Comparative Examples 1-6. Place them on a high-hardness glass plate, weigh linseed oil by the loss method using a precision balance, and use a mixing knife to fully roll and mix the sample with linseed oil. Drop the test oil as needed while rolling until there is no excess free powder and no excess grease, which is the test end point. Record the weight of the test oil used and convert it to the unit: g / 100 g.

[0212] The specific test results are shown in Table 5 below. As can be seen from Table 5, the oil absorption capacity reflects the integrity of the modification of inorganic powder and the dispersion performance of inorganic powder from the side. The lower the oil absorption capacity, the more complete the coating of inorganic powder and the better the dispersion performance. The oil absorption capacity of Example 2 is also lower than that of Comparative Examples 1-6.

[0213] Table 5

[0214] Sample Oil absorption Example 2 15.34 g / 100 g Comparative Example 1 19.27 g / 100 g Comparative Example 2 22.98 g / 100 g Comparative Example 3 19.65 g / 100 g Comparative Example 4 28.50 g / 100 g Comparative Example 5 27.62 g / 100 g Comparative Example 6 19.32 g / 100 g

[0215] (3) Dispersion performance of inorganic powder

[0216] Take 10 g of the inorganic powder sample 2# of Example 2 and the samples prepared in Comparative Examples 1-6, mix them with 20 g of the dispersion medium, stir with a high-speed dispersion disk at a rotation speed of 1400 rpm for 20 minutes, take samples, detect the fineness using a scraping fineness gauge, and observe the particle dispersion situation with a microscope at the same time.

[0217] The specific test results are shown in Table 6 below. As can be seen from Table 6, the scraping fineness gauge can directly measure the particle size and the distribution of large particles in the sample slurry. The smaller the fineness of the inorganic powder and the fewer the number of particles, the better its dispersion performance, and the finer the use feeling of the inorganic powder. According to the results, the dispersion performance of Example 2 is very excellent, without scratches, indicating that its dispersion is very uniform and very fine.

[0218] Table 6

[0219] Sample Fineness Particle number Example 2 No scratch appeared (regarded as 0 μm) 0 Comparative Example 1 18 μm 2 Comparative Example 2 23 μm 3 Comparative Example 3 27 μm 3 Comparative Example 4 48 μm 5 Comparative Example 5 12 μm 2 Comparative Example 6 21 μm 2

[0220] The same results were observed for the samples prepared in Comparative Examples 1-5 using a microscope. The specific test results are shown in Figure 3a 、 3b 、3c、3d、3e、3f. As can be seen from Figure 3a 、 3b 、3c、3d、3e、3f, the smaller and more uniform the dark shadows formed by the inorganic powder, the fewer the agglomerations caused by poor dispersion performance of the powder. According to the image observation, the overall dispersion of Example 2 is very uniform, without large dark shadows caused by the agglomeration of inorganic powder. Large dark shadows appear in all other comparative examples, and the overall trend is consistent with the fineness results.

[0221] Example 12

[0222] Prepare the liquid foundation samples according to the ratios in Table 7. The specific preparation process is as follows: Mix the emulsifier, silicone oil, and synthetic oil evenly according to the ratio to obtain a mixed phase; Add the inorganic powder sample 2# of Example 2 to the mixed phase and disperse for 20 minutes to obtain an oil phase; Mix deionized water, humectant, and chelating agent evenly to obtain an aqueous phase; Heat the oil phase and the aqueous phase to 85°C respectively and keep warm for 30 minutes. In the first stirring, pour the aqueous phase into the oil phase at 2000 rpm and mix at low speed for homogenization. Then, in the second stirring, perform the first emulsification reaction at 4000 rpm for 5 minutes at high speed. Then, cool down the stirring to 40°C, and in the third stirring, add the preservative at 2000 rpm and perform the second emulsification reaction at low speed for 2 minutes to provide the required liquid foundation sample 1#. This liquid foundation sample 1# does not add film-forming agents and other waterproof and long-lasting makeup ingredients.

[0223] Table 7

[0224] Number Raw material Content (%) 1 Emulsifier 3.5 2 Silicone oil 16.5 3 Synthetic grease 12 4 Inorganic powder sample 2# 12 5 Water Add up to 100 6 Humectant 9 7 Chelating agent 0.3 8 Preservative 0.7

[0225] Comparative Example 7

[0226] Prepare the comparative liquid foundation samples 1-5 with the different modified inorganic powders prepared in Comparative Examples 1-5 using the same ratios and preparation processes as in Example 12.

[0227] Example 13

[0228] Centrifuge the liquid foundation sample 1# of Example 12 and the comparative liquid foundation samples 1-5 prepared in Comparative Example 7 respectively. The centrifuge conditions are 3000 rpm for 30 minutes. After centrifugation, observe the oiling or color band precipitation on the surface of the samples. At the same time, observe the emulsification structure, droplet size, and uniformity of the liquid foundation under a microscope. The specific test results are shown in Figure 4 、 5a 、5b, 5c, 5d, 5e, 5f.

[0229] From Figure 4 it can be seen that through the centrifuge test, observing the oiling, layering, and color bleeding of the samples. It can be seen that the liquid foundation sample 1# of Example 12 has a uniform body, without oiling, layering, color bleeding and other adverse phenomena, indicating good stability. Among the comparative liquid foundation samples 1, 2, and 5 prepared in Comparative Example 7 based on Comparative Examples 1, 2, and 5, there are varying degrees of oiling and layering phenomena. Among the comparative liquid foundation samples 3 and 4 prepared in Comparative Example 7 based on Comparative Examples 3 and 4, there are oiling and layering phenomena and serious color bleeding phenomena.

[0230] From Figure 5a 、 5bAs can be seen from 5c, 5d, 5e, and 5f, through microscopic observation, it can be seen that the emulsified structure of the liquid foundation sample 1# of Example 12 is uniform, the droplet size is uniform, and there is no agglomeration of large inorganic powders or aggregation of large vacuoles. This phenomenon is the same as its performance in the centrifugation test, indicating its top-notch stability. For the remaining Comparative Example 7 in preparing Comparative Liquid Foundation Samples 1-5, there are various phenomena of poor stability. For example: in Comparative Liquid Foundation Sample 1 prepared based on Comparative Example 1 in Comparative Example 7, the droplet size is uneven and there is a tendency for droplets to aggregate; in Comparative Liquid Foundation Samples 2 and 3 prepared based on Comparative Examples 2 and 3 in Comparative Example 7, there is agglomeration of large inorganic powders; in Comparative Liquid Foundation Sample 4 prepared based on Comparative Example 4 in Comparative Example 7, the emulsified structure is incomplete, the oil phase, water phase, and inorganic powders exist separately, and the droplet size is uneven; in Comparative Liquid Foundation Sample 5 prepared based on Comparative Example 5 in Comparative Example 7, a large number of droplets aggregate and inorganic powders are found in the droplets, indicating that the inorganic powders have destroyed the emulsification interface into the water phase.

[0231] Example 14

[0232] To measure the waterproof and long-lasting performance of the application of inorganic powders, that is, take the same mass of the liquid foundation sample 1# of Example 12 and Comparative Liquid Foundation Samples 1-5 prepared in Comparative Example 7, apply them to the specified areas on the arm, wait for 5 minutes, rinse with water for 10 seconds, then press a tissue on the sample application area with the same force, absorb the moisture, and observe the situation of the sample stained on the tissue for comparison. The specific test results are shown in Figure 6a 、 6b 。

[0233] From Figure 6a 、 6b it can be seen that according to the liquid foundation stained on the tissue, the liquid foundation sample 1# of Example 12 has the best waterproof performance and is basically not stained by the tissue, while there are obvious staining situations for Comparative Liquid Foundation Samples 1-5 prepared based on Comparative Examples 1-5 in Comparative Example 7. This shows that without the addition of a film-forming agent, the liquid foundation sample 1# of Example 12 already has very good waterproof performance.

[0234] Example 15

[0235] Conduct a comparative test on the waterproof and long-lasting performance of the liquid foundation sample 1# prepared in Example 12 and the benchmark competing product of long-lasting liquid foundation purchased on the market.

[0236] Take the same mass of the liquid foundation sample 1# and the commercially available benchmark competing product liquid foundation, apply them to the specified areas on the arm. The specific test results are shown in Figure 7a 。

[0237] Then, wait for 5 minutes, rinse with water for 10 seconds, observe the state of water droplets on the surface of the application area. The specific test results are shown inFigure 7b 。It can be observed that the water droplets in the application area of the liquid foundation sample 1# are in the shape of water beads (similar to the state of water beads on the surface of a lotus leaf), while the water droplets in the application area of the commercially available benchmark competitor are in a spreading state. It can be concluded that the application area of the liquid foundation sample 1# has better waterproof performance.

[0238] Finally, press a tissue paper on the sample application area with the same force. After absorbing the moisture, observe the situation of the sample contaminated on the tissue paper. The specific test results are shown in Figure 7c 。There is no phenomenon of the liquid foundation being contaminated in the application area of the liquid foundation sample 1#, but there is an obvious situation of the commercially available benchmark competitor being contaminated by the tissue paper in the application area. It can be concluded that in the application area of the liquid foundation sample 1# prepared in Example 12, without adding a film-forming agent, through the modification of the phosphocholine copolymer, better waterproof and long-lasting makeup performance is obtained.

[0239] The above embodiments are for illustrating the implementation schemes disclosed in the present invention and should not be construed as limitations on the present invention. In addition, various modifications listed herein and changes in the methods of the invention are obvious to those skilled in the art without departing from the scope and spirit of the present invention. Although the present invention has been specifically described in conjunction with various specific preferred embodiments of the present invention, it should be understood that the present invention should not be limited to these specific embodiments. In fact, all obvious modifications to those skilled in the art as described above to obtain the invention should be included within the scope of the present invention.

Claims

1. A method for modifying inorganic powder with phosphorylcholine copolymer, comprising the following steps: 1) Dissolve the phosphorylcholine copolymer in a solvent to obtain a phosphorylcholine copolymer solution; 2) Pulverize and disperse the inorganic powder, filter it, and then add it to water for dispersion and mixing to obtain a slurry; 3) Stir the slurry under normal temperature and vacuum conditions, dropwise add the phosphorylcholine copolymer solution, then heat and stir for mixing, vacuum dry, pulverize and disperse to provide the inorganic powder modified with phosphorylcholine copolymer.

2. The modification method of inorganic powder by the phosphorylcholine copolymer according to claim 1, characterized in that Step 1) includes any one or more of the following conditions: A1) The chemical structure of the phosphorylcholine copolymer is shown in formula (I): In formula (I), x > 0; z > 0; y ≥ 0; 0 ≤ m ≤ 25; R is selected from H, (CH2) n OH, (CH2) n CHOCH2 or (CH2) n NH2, where 0 ≤ n ≤ 8; A2) The solvent is selected from one or a combination of more of water, ethanol, isopropanol, butanediol, isododecane, polydimethylsiloxane or water-in-oil emulsifier; preferably, the water-in-oil emulsifier is a polyglycerol emulsifier; A3) The mass ratio of the phosphorylcholine copolymer to the solvent added is 1:1 - 30.

3. The method for modifying inorganic powder by the phosphorylcholine copolymer according to claim 1, characterized in that Step 2) includes any one or more of the following conditions: B1) The inorganic powder is selected from at least one of titanium dioxide, iron oxide, zinc oxide, mica powder, talc powder, boron nitride, pearl powder, kaolin, chromium sesquioxide, ultramarine, calamine, zinc carbonate, bismuth oxychloride; B2) The number of times of pulverizing and dispersing is not less than 5 times; B3) The filtration is screen filtration; preferably, the pore size of the screen for screen filtration is 10 - 60 μm; B4) The mass ratio of the filtered inorganic powder to water is 1:0.1 - 5; B5) The potential of the slurry needs to be adjusted, and the potential of the slurry is adjusted to zero.

4. The method for modifying inorganic powder with the phosphorylcholine copolymer according to claim 1, characterized in that, Step 4) includes any one or more of the following conditions: C1) The vacuum degree of the vacuum state is -0.3~-0.1 Mpa; C2) The mass ratio of the phosphorylcholine copolymer in the phosphorylcholine copolymer solution to the inorganic powder in the slurry added is 0.001 - 3:100; C3) The heating temperature is 20 - 120 °C; C4) The stirring and mixing time is 0.1 - 3 hours; C5) The vacuum drying temperature is 40 - 120 °C; C6) The vacuum degree of the vacuum drying is -1 Mpa~-0.1 Mpa; C7) The vacuum drying time is 0.1 - 5 hours.

5. An inorganic powder obtained by the method for modifying inorganic powder with phosphorylcholine copolymer according to any one of claims 1 - 4.

6. Use of the inorganic powder according to claim 5 in cosmetics.

7. A liquid foundation containing the inorganic powder according to claim 5.

8. The liquid foundation according to claim 7, characterized in that, The liquid foundation, by weight percentage, comprises the following components: Emulsifier 1 - 5%; Silicone oil 10 - 25%; Synthetic grease 8 - 16%; Inorganic powder 3 - 21%; Humectant 2 - 15%; Chelating agent 0.1 - 1%; Preservative 0.3 - 2%; The balance is water.

9. A method for preparing the liquid foundation according to any one of claims 7 - 8, comprising the following steps: A) Mix the emulsifier, silicone oil, and synthetic grease evenly to obtain a mixed phase; B) Add the inorganic powder to the mixed phase for dispersion to obtain an oil phase; C) Mix water, humectant, and chelating agent evenly to obtain an aqueous phase; D) Heat the oil phase and the water phase separately and then keep them at a constant temperature. Pour the water phase into the oil phase during the first stirring for mixing, then conduct the first emulsification reaction during the second stirring. After that, cool down by stirring and add the preservative during the third stirring for the second emulsification reaction to provide the desired liquid foundation.

10. The preparation method of the liquid foundation according to claim 9, characterized in that, including any one or more of the following conditions: D1) In step A), the stirring speed of the mixing is 800 - 1200 rpm; D2) In step A), the stirring time of the mixing is 8 - 12 min; D3) In step B), the dispersion time is not less than 20 min; D4) In step B), the stirring speed of the dispersion is 1300 - 1500 rpm; D5) In step C), the stirring speed of the mixing is 600 - 1800 rpm; D6) In step C), the stirring time of the mixing is 14 - 16 min; D7) In step D), the heating temperature is 80 - 90 °C; D8) In step D), the heat preservation time is 25 - 35 min; D9) In step D), the stirring rate of the first stirring is 1500 - 2500 rpm; D10) In step D), the stirring time of the first stirring is 4 - 6 min; D11) In step D), the stirring rate of the second stirring is 3500 - 4500 rpm; D12) In step D), the stirring time of the second stirring is not less than 5 min; D13) In step D), stir and cool down to 35 - 45 °C; D14) In step D), the stirring rate of the stirring and cooling down is 40 - 60 rpm; D15) In step D), the stirring rate of the third stirring is 1500 - 2500 rpm; D16) In step D), the stirring time of the third stirring is not less than 2 min.

Images