Temperature control method and system for solid phase collection device

Abstract

The present invention relates to the technical field of instrument temperature control, and discloses a temperature control method and system for a solid phase collection device, the method comprising: obtaining a first temperature value of a sample to be processed at a column tube inlet, and determining a sample temperature adjustment amount for the sample to be processed; after the adsorbent in the column tube completes adsorption of the sample to be processed, obtaining a flow rate, a pressure value, and a second temperature value of an eluent at the column tube inlet; determining an eluent temperature adjustment amount, a flow rate adjustment amount, and a pressure adjustment amount of the eluent based on the second temperature value; setting a pump operating state based on the flow rate and pressure of the eluent according to the flow rate adjustment amount and the pressure adjustment amount; controlling a temperature adjustment module to adjust the temperature of the sample to be processed according to the sample temperature adjustment amount, and controlling the pump according to the operating state of the pump to achieve temperature control of the solid phase collection device. The present invention can achieve high-precision and fast-response temperature control, thereby improving product quality and production efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of instrument temperature control, and in particular to a temperature control method and system for a solid phase collection device. Background Art

[0002] Solids collection devices are widely used in various industrial processes, such as chemical production, pharmaceutical processing, and food processing. These devices are typically used to separate and collect solid particles from gas or liquid mixtures. These processes often require precise temperature control of the solids collection device to ensure product quality and production efficiency.

[0003] However, conventional solid-phase collection devices have several shortcomings in temperature control, such as insufficient temperature control precision, slow response speed, and susceptibility to environmental factors. These issues can lead to low solid-phase collection efficiency, unstable collection quality, and even affect subsequent experiments or production processes. Therefore, a temperature control method and system for solid-phase collection devices are urgently needed to achieve precise temperature control during the solid-phase collection process. Summary of the Invention

[0004] The purpose of the present invention is to provide a temperature control method and system for a solid phase collection device to solve the problems of traditional solid phase collection devices having low temperature control accuracy, slow response speed and being easily affected by environmental factors.

[0005] The present invention provides a temperature control method for a solid phase collection device, which is applied to the solid phase collection device. The solid phase collection device includes a column tube, an adsorbent, an eluent container, a pump, and a control module. The column tube is filled with the adsorbent, the eluent container is connected to the column tube, the pump is arranged between the eluent container and the column tube, the pump is used to control the flow rate and pressure of the eluent, and the control module is connected to the pump to control the working state of the pump.

[0006] The method comprises:

[0007] Acquiring a first temperature value of the sample to be processed at the column tube inlet, and determining a sample temperature adjustment amount of the sample to be processed according to the first temperature value;

[0008] After the adsorbent in the column tube completes adsorption of the sample to be processed, the flow rate, pressure value and second temperature value of the eluent at the column tube inlet are obtained;

[0009] determining an eluent temperature adjustment amount of the eluent according to the second temperature value;

[0010] determining a flow rate adjustment amount and a pressure adjustment amount of the eluent according to the temperature adjustment amount of the eluent;

[0011] Based on the flow rate and pressure of the eluent, setting the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount;

[0012] The temperature adjustment module is controlled according to the sample temperature adjustment amount to adjust the temperature of the sample to be processed, and the pump is controlled according to the working state of the pump to achieve temperature control of the solid phase collection device.

[0013] Preferably, determining the sample temperature adjustment amount of the sample to be processed according to the first temperature value includes:

[0014] Preset sample temperature;

[0015] determining a sample temperature difference between the first temperature value and the sample preset temperature;

[0016] determining a sample temperature adjustment amount of the sample to be processed according to the sample temperature difference;

[0017] The sample temperature adjustment amount is ∆T1=|Ty1-Ty0|, where Ty1 is the first temperature value and Ty0 is the preset temperature of the sample.

[0018] Preferably, determining the sample temperature adjustment amount of the sample to be processed according to the first temperature value further includes:

[0019] When the first temperature value is greater than the preset temperature of the sample, cooling the sample to be processed;

[0020] When the first temperature value is lower than the preset temperature of the sample, the sample to be processed is heated and adjusted.

[0021] Preferably, determining the eluent temperature adjustment amount of the eluent according to the second temperature value includes:

[0022] determining a temperature difference of the eluent between the second temperature value and a preset temperature of the eluent;

[0023] Presetting a first eluent temperature difference, a second eluent temperature difference, and a third eluent temperature difference, wherein the first eluent temperature difference, the second eluent temperature difference, and the third eluent temperature difference increase in sequence;

[0024] setting an eluent temperature adjustment amount of the eluent according to a relationship between the eluent temperature difference and the first eluent temperature difference, the second eluent temperature difference, and the third eluent temperature difference;

[0025] If the eluent temperature difference is less than the first eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the first preset temperature adjustment amount Ts1;

[0026] If the eluent temperature difference is greater than or equal to the first eluent temperature difference, and the eluent temperature difference is less than the second eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the second preset temperature adjustment amount Ts2;

[0027] If the eluent temperature difference is greater than or equal to the second eluent temperature difference, and the eluent temperature difference is less than the third eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the third preset temperature adjustment amount Ts3;

[0028] If the eluent temperature difference is greater than or equal to the third eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to a fourth preset temperature adjustment amount Ts4; wherein Ts1<Ts2<Ts3<Ts4.

[0029] Preferably, determining the flow rate adjustment amount and the pressure adjustment amount of the eluent according to the temperature adjustment amount of the eluent includes:

[0030] If the eluent temperature adjustment amount of the eluent is the first preset temperature adjustment amount Ts1, the flow rate adjustment amount is set to the first preset flow rate adjustment amount V1, and the pressure adjustment amount is set to the first preset pressure adjustment amount P1;

[0031] If the eluent temperature adjustment amount of the eluent is the second preset temperature adjustment amount Ts2, the flow rate adjustment amount is set to the second preset flow rate adjustment amount V2, and the pressure adjustment amount is set to the second preset pressure adjustment amount P2;

[0032] If the eluent temperature adjustment amount of the eluent is the third preset temperature adjustment amount Ts3, the flow rate adjustment amount is set to the third preset flow rate adjustment amount V3, and the pressure adjustment amount is set to the third preset pressure adjustment amount P3;

[0033] If the eluent temperature adjustment amount of the eluent is the fourth preset temperature adjustment amount Ts4, then the flow rate adjustment amount is set to the fourth preset flow rate adjustment amount V4, and the pressure adjustment amount is set to the fourth preset pressure adjustment amount P4; wherein V1<V2<V3<V4, P1<P2<P3<P4.

[0034] Preferably, based on the flow rate and pressure of the eluent, setting the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount includes:

[0035] determining a required flow rate of the eluent according to the flow rate of the eluent and the flow rate adjustment amount;

[0036] determining the required pressure of the eluent according to the pressure of the eluent and the pressure adjustment amount;

[0037] The working state of the pump is set according to the required flow rate and the required pressure.

[0038] Preferably, setting the working state of the pump according to the required flow rate and the required pressure includes:

[0039] determining an initial motor speed of the pump according to the required flow rate;

[0040] A first preset demand flow rate, a second preset demand flow rate and a third preset demand flow rate are preset and set, wherein the first preset demand flow rate, the second preset demand flow rate and the third preset demand flow rate increase in sequence;

[0041] setting an initial motor speed of the pump according to a relationship between the required flow rate and the first preset required flow rate, the second preset required flow rate, and the third preset required flow rate;

[0042] If the required flow rate is less than the first preset required flow rate, the initial motor speed of the pump is set to the first preset motor speed N1;

[0043] If the required flow rate is greater than or equal to the first preset required flow rate, and the required flow rate is less than the second preset required flow rate, setting the initial motor speed of the pump to the second preset motor speed N2;

[0044] If the required flow rate is greater than or equal to the second preset required flow rate, and the required flow rate is less than the third preset required flow rate, then setting the initial motor speed of the pump to the third preset motor speed N3;

[0045] If the required flow rate is greater than or equal to the third preset required flow rate, the initial motor speed of the pump is set to a fourth preset motor speed N4; wherein N1 < N2 < N3 < N4.

[0046] Preferably, the working state of the pump is set according to the required flow rate and the required pressure, further comprising:

[0047] After the initial motor speed of the pump is set to the i-th preset motor speed Ni according to the relationship between the required flow rate and the first preset required flow rate, the second preset required flow rate, and the third preset required flow rate, i=1, 2, 3, 4, the i-th preset motor speed Ni is adjusted according to the required pressure to obtain the final motor speed of the pump;

[0048] Presetting a first preset demand pressure, a second preset demand pressure, and a third preset demand pressure, wherein the first preset demand pressure, the second preset demand pressure, and the third preset demand pressure increase in sequence;

[0049] adjusting the i-th preset motor speed Ni according to the relationship between the demand pressure and the first preset demand pressure, the second preset demand pressure, and the third preset demand pressure to obtain a final motor speed of the pump;

[0050] If the required pressure is less than the first preset required pressure, the first speed correction coefficient m1 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m1;

[0051] If the demand pressure is greater than or equal to the first preset demand pressure and the demand pressure is less than the second preset demand pressure, then the second speed correction coefficient m2 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m2;

[0052] If the demand pressure is greater than or equal to the second preset demand pressure and is less than the third preset demand pressure, the third speed correction coefficient m3 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m3;

[0053] If the demand pressure is greater than or equal to the third preset demand pressure, the fourth speed correction coefficient m4 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m4; wherein m1<m2<m3<m4.

[0054] The present invention also discloses a temperature control system for a solid phase collection device, which is used to apply the temperature control method for a solid phase collection device. The system comprises:

[0055] A temperature adjustment module, used for adjusting the temperature of the sample to be processed;

[0056] an acquisition module, configured to acquire a first temperature value of the sample to be processed at the column tube inlet, and to acquire a flow rate, a pressure value, and a second temperature value of the eluent at the column tube inlet after the adsorbent in the column tube completes adsorption of the sample to be processed;

[0057] a processing module, configured to determine a sample temperature adjustment amount of the sample to be processed according to the first temperature value, determine an eluent temperature adjustment amount of the eluent according to the second temperature value, and determine a flow rate adjustment amount and a pressure adjustment amount of the eluent according to the eluent temperature adjustment amount;

[0058] a setting module, configured to set the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount based on the flow rate and pressure of the eluent;

[0059] The control module is used to control the temperature adjustment module to adjust the temperature of the sample to be processed according to the sample temperature adjustment amount, and to control the pump according to the working state of the pump to achieve temperature control of the solid phase collection device.

[0060] Compared with existing technologies, the present invention offers the following advantages: by precisely controlling the temperature of the sample to be processed and the eluent, it can optimize the adsorption and desorption processes of the target analyte on the adsorbent, thereby improving separation efficiency. By controlling and maintaining a constant temperature, it can reduce sample degradation or structural changes caused by temperature fluctuations, thereby ensuring the stability of the analyte. The present invention enables highly precise and responsive temperature control, thereby improving product quality and production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without any creative work.

[0062] Figure 1 It is a schematic flow chart of a temperature control method for a solid phase collection device of the present invention;

[0063] Figure 2 It is a functional block diagram of a temperature control system for a solid phase collection device of the present invention. DETAILED DESCRIPTION

[0064] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0065] like Figure 1 As shown, the present invention provides a temperature control method for a solid phase collection device, which is applied to a solid phase collection device, wherein the solid phase collection device includes a column tube, an adsorbent, an eluent container, a pump and a control module, the column tube is filled with an adsorbent, the eluent container is connected to the column tube, the pump is arranged between the eluent container and the column tube, the pump is used to control the flow rate and pressure of the eluent, and the control module is connected to the pump for controlling the working state of the pump.

[0066] The method comprises:

[0067] S1, obtaining a first temperature value of the sample to be processed at the column tube inlet, and determining a sample temperature adjustment amount of the sample to be processed according to the first temperature value.

[0068] S2, after the adsorbent in the column tube completes the adsorption of the sample to be processed, obtaining the flow rate, pressure value and second temperature value of the eluent at the column tube inlet.

[0069] S3: Determine an eluent temperature adjustment amount of the eluent according to the second temperature value.

[0070] S4, determining the flow rate adjustment amount and the pressure adjustment amount of the eluent according to the temperature adjustment amount of the eluent.

[0071] S5 , based on the flow rate and pressure of the eluent, setting the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount.

[0072] S6, controlling the temperature adjustment module to adjust the temperature of the sample to be processed according to the sample temperature adjustment amount, and controlling the pump according to the working state of the pump to achieve temperature control of the solid phase collection device.

[0073] In some embodiments of the present application, the sample temperature adjustment amount of the sample to be processed is determined according to the first temperature value, including: presetting the sample preset temperature; determining the sample temperature difference between the first temperature value and the sample preset temperature; determining the sample temperature adjustment amount of the sample to be processed according to the sample temperature difference; the sample temperature adjustment amount is ∆T1=|Ty1-Ty0|, where Ty1 is the first temperature value and Ty0 is the sample preset temperature.

[0074] In this embodiment, in order to ensure that the sample to be processed reaches the optimal temperature when adsorbed in the column tube, the temperature of the sample to be processed needs to be adjusted, such as heating or cooling. In some cases, the sample to be processed needs to be heated to a certain temperature to promote its adsorption process in the column tube. This is mainly because certain chemical reactions or physical processes become more active at higher temperatures. In addition, heating can also accelerate the movement speed of molecules, helping the target components in the sample to diffuse into the interior of the column tube faster, thereby achieving more efficient adsorption. In certain specific cases, cooling the sample to be processed can also achieve the purpose of optimizing the adsorption effect. Cooling can slow down the movement speed of molecules and reduce the diffusion speed of the target components in the sample, thereby making it more concentratedly adsorbed in the column tube. In addition, cooling can also change the solubility of certain substances, making components that are originally difficult to adsorb easier to be adsorbed at low temperatures. Therefore, whether heating or cooling is determined according to the properties of the solid phase to be collected.

[0075] In some embodiments of the present application, determining the sample temperature adjustment amount of the sample to be processed based on the first temperature value also includes: when the first temperature value is greater than the sample preset temperature, cooling the sample to be processed; when the first temperature value is less than the sample preset temperature, heating the sample to be processed.

[0076] In this embodiment, the sample preset temperature is determined according to the properties of the solid phase to be collected. If the solid phase to be collected is easily adsorbed at high temperature, a higher sample preset temperature is set; if the solid phase to be collected is easily adsorbed at low temperature, a lower sample preset temperature is set.

[0077] In some embodiments of the present application, determining the eluent temperature adjustment amount of the eluent according to the second temperature value includes: determining the eluent temperature difference between the second temperature value and the eluent preset temperature.

[0078] A first eluent temperature difference, a second eluent temperature difference and a third eluent temperature difference are preset, and the first eluent temperature difference, the second eluent temperature difference and the third eluent temperature difference increase in sequence.

[0079] The eluent temperature adjustment amount of the eluent is set according to the relationship between the eluent temperature difference and the first eluent temperature difference, the second eluent temperature difference, and the third eluent temperature difference.

[0080] If the eluent temperature difference is less than the first eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to the first preset temperature adjustment amount Ts1; if the eluent temperature difference is greater than or equal to the first eluent temperature difference, and the eluent temperature difference is less than the second eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to the second preset temperature adjustment amount Ts2; if the eluent temperature difference is greater than or equal to the second eluent temperature difference, and the eluent temperature difference is less than the third eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to the third preset temperature adjustment amount Ts3; if the eluent temperature difference is greater than or equal to the third eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to the fourth preset temperature adjustment amount Ts4; wherein, Ts1<Ts2<Ts3<Ts4.

[0081] In this embodiment, after completing the separation task, the solid phase collection device usually needs to be further processed with the help of an eluent in order to more thoroughly remove impurities and purify the target component, thereby laying a solid foundation for subsequent experimental steps. The eluent can effectively remove non-target components adsorbed on the solid phase material. These non-target components may include impurities, interferents or other unwanted substances, which will have a negative impact on the separation and purification of the target component. By using an appropriate eluent, these non-target components can be eluted from the solid phase material, thereby improving the purity of the target component. During the elution process, the temperature of the eluent is equally important. At a suitable temperature, the eluent can elute the sample solid phase adsorbed on the adsorbent with the highest efficiency.

[0082] In some embodiments of the present application, the flow rate adjustment amount and the pressure adjustment amount of the eluent are determined according to the eluent temperature adjustment amount, including: if the eluent temperature adjustment amount of the eluent is the first preset temperature adjustment amount Ts1, the flow rate adjustment amount is set to the first preset flow rate adjustment amount V1, and the pressure adjustment amount is set to the first preset pressure adjustment amount P1; if the eluent temperature adjustment amount of the eluent is the second preset temperature adjustment amount Ts2, the flow rate adjustment amount is set to the second preset flow rate adjustment amount V2, and the pressure adjustment amount is set to the second preset pressure adjustment amount P1. Preset pressure adjustment amount P2; if the eluent temperature adjustment amount of the eluent is the third preset temperature adjustment amount Ts3, the flow rate adjustment amount is set to the third preset flow rate adjustment amount V3, and the pressure adjustment amount is set to the third preset pressure adjustment amount P3; if the eluent temperature adjustment amount of the eluent is the fourth preset temperature adjustment amount Ts4, the flow rate adjustment amount is set to the fourth preset flow rate adjustment amount V4, and the pressure adjustment amount is set to the fourth preset pressure adjustment amount P4; wherein, V1<V2<V3<V4, P1<P2<P3<P4.

[0083] In this embodiment, liquid temperature, as a key parameter of liquid state, is often influenced by a combination of factors. Among these factors, liquid flow rate and pressure are particularly critical. Liquid flow rate is one of the most important factors affecting its temperature. The speed of the flow rate is directly related to the frequency and intensity of interactions between liquid molecules. When the liquid flow rate is faster, intermolecular collisions and friction intensify, releasing more heat and causing the liquid temperature to rise. Conversely, when the flow rate is slower, intermolecular interactions weaken, reducing heat release and correspondingly lowering the liquid temperature. This phenomenon is particularly evident in industrial production. For example, controlling the liquid flow rate in cooling systems directly affects the equipment's heat dissipation and temperature stability. Liquid pressure also has a significant impact on temperature. Pressure is closely related to the distance and interaction forces between liquid molecules. Under high pressure, the distance between liquid molecules is compressed closer, increasing interaction forces. This results in faster molecular motion, which in turn releases more heat and increases the liquid temperature. Under low pressure, the distance between molecules increases, weakening interaction forces and correspondingly lowering the liquid temperature. Therefore, in the fields of chemical production, hydraulic systems, etc., controlling liquid pressure is also one of the key means to achieve temperature regulation. Therefore, liquid temperature is positively correlated with liquid flow rate and liquid pressure.

[0084] In some embodiments of the present application, based on the flow rate and pressure of the eluent, the working state of the pump is set according to the flow rate adjustment amount and the pressure adjustment amount, including: determining the required flow rate of the eluent according to the flow rate of the eluent and the flow rate adjustment amount; determining the required pressure of the eluent according to the pressure of the eluent and the pressure adjustment amount; and setting the working state of the pump according to the required flow rate and the required pressure.

[0085] In this embodiment, the flow rate and pressure of the pump are closely related to the speed of the pump motor. A pump is a mechanical device driven by an electric motor that transports liquid from a low location to a high location. In this process, the motor speed directly determines the pump speed, which in turn affects the flow rate and pressure of the liquid. When the motor speed increases, the pump speed also increases, which causes the liquid flow rate inside the pump to increase. The increased flow rate means that the amount of liquid passing through the pump per unit time increases, thereby improving the pump's delivery capacity. At the same time, the increased flow rate also leads to an increase in pressure. This is because the liquid is affected by friction and resistance during flow. When the flow rate increases, these forces increase, resulting in an increase in pressure. Therefore, the operating state of the pump, that is, the motor speed, is determined by determining the required flow rate and required pressure.

[0086] In some embodiments of the present application, the working state of the pump is set according to the required flow rate and the required pressure, including: determining the initial motor speed of the pump according to the required flow rate; presetting a first preset required flow rate, a second preset required flow rate and a third preset required flow rate, wherein the first preset required flow rate, the second preset required flow rate and the third preset required flow rate increase in sequence; setting the initial motor speed of the pump according to the relationship between the required flow rate and the first preset required flow rate, the second preset required flow rate and the third preset required flow rate; if the required flow rate is less than the first preset required flow rate, setting the initial motor speed of the pump The speed is the first preset motor speed N1; if the required flow rate is greater than or equal to the first preset required flow rate, and the required flow rate is less than the second preset required flow rate, the initial motor speed of the pump is set to the second preset motor speed N2; if the required flow rate is greater than or equal to the second preset required flow rate, and the required flow rate is less than the third preset required flow rate, the initial motor speed of the pump is set to the third preset motor speed N3; if the required flow rate is greater than or equal to the third preset required flow rate, the initial motor speed of the pump is set to the fourth preset motor speed N4; wherein, N1<N2<N3<N4.

[0087] In some embodiments of the present application, the working state of the pump is set according to the demand flow rate and the demand pressure, and also includes: after the initial motor speed of the pump is set to the i-th preset motor speed Ni according to the relationship between the demand flow rate and the first preset demand flow rate, the second preset demand flow rate and the third preset demand flow rate, i=1, 2, 3, 4, the i-th preset motor speed Ni is adjusted according to the demand pressure to obtain the final motor speed of the pump; the first preset demand pressure, the second preset demand pressure and the third preset demand pressure are pre-set, and the first preset demand pressure, the second preset demand pressure and the third preset demand pressure increase in sequence; the i-th preset motor speed Ni is adjusted according to the relationship between the demand pressure and the first preset demand pressure, the second preset demand pressure and the third preset demand pressure to obtain the final motor speed of the pump; if the demand pressure is less than the first preset demand pressure, the i-th preset motor speed Ni is selected. A speed correction coefficient m1 is used to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m1; if the demand pressure is greater than or equal to the first preset demand pressure, and the demand pressure is less than the second preset demand pressure, the second speed correction coefficient m2 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m2; if the demand pressure is greater than or equal to the second preset demand pressure, and the demand pressure is less than the third preset demand pressure, the third speed correction coefficient m3 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m3; if the demand pressure is greater than or equal to the third preset demand pressure, the fourth speed correction coefficient m4 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m4; wherein, m1<m2<m3<m4.

[0088] In this embodiment, the pump speed is positively correlated with the liquid flow rate and liquid pressure. Therefore, by determining the range of the required flow rate and required pressure, the corresponding initial motor speed and correction coefficient are selected to obtain the final motor speed.

[0089] The present invention also discloses a temperature control system for a solid phase collecting device, which is used to apply the temperature control method for a solid phase collecting device, such as Figure 2 As shown, the system includes: a temperature adjustment module for adjusting the temperature of the sample to be processed.

[0090] The acquisition module is used to obtain the first temperature value of the sample to be processed at the column tube inlet, and to obtain the flow rate, pressure value and second temperature value of the eluent at the column tube inlet after the adsorbent in the column tube completes the adsorption of the sample to be processed.

[0091] A processing module is used to determine the sample temperature adjustment amount of the sample to be processed according to the first temperature value, determine the eluent temperature adjustment amount of the eluent according to the second temperature value, and determine the flow rate adjustment amount and pressure adjustment amount of the eluent according to the eluent temperature adjustment amount.

[0092] A setting module is used to set the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount based on the flow rate and pressure of the eluent.

[0093] The control module is used to control the temperature adjustment module to adjust the temperature of the sample to be processed according to the sample temperature adjustment amount, and to control the pump according to the working state of the pump to achieve temperature control of the solid phase collection device.

[0094] By precisely controlling the temperature of the sample to be processed and the eluent, the present invention can optimize the adsorption and desorption processes of the target analyte on the adsorbent, thereby improving the separation efficiency and achieving high-precision and fast-response temperature control, thereby improving product quality and production efficiency. By controlling the temperature and maintaining a constant temperature, sample degradation or structural changes caused by temperature fluctuations can be reduced, thereby ensuring the stability of the analyte.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the same. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solutions of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

[0096] The system provided in the above embodiment is only illustrated by the division of the above functional modules. In actual applications, the above functions can be assigned to different functional modules as needed, that is, the modules or steps in the embodiments of the present invention can be further decomposed or combined. For example, the modules in the above embodiment can be combined into one module or further divided into multiple sub-modules to complete all or part of the functions described above. The names of the modules and steps involved in the embodiments of the present invention are only for distinguishing the modules or steps and are not to be regarded as improper limitations of the present invention.

[0097] Those skilled in the art should be able to appreciate that, in conjunction with the modules and method steps of each example described in the embodiments disclosed herein, it is possible to implement them with electronic hardware, computer software, or a combination of the two, and the programs corresponding to the software modules and method steps can be placed in random access memory (RAM), internal memory, read-only memory (ROM), electrically programmable ROM, electrically erasable programmable ROM, registers, hard disks, removable disks, CD-ROMs, or any other form of storage medium known in the art. In order to clearly illustrate the interchangeability of electronic hardware and software, the composition and steps of each example have been generally described in terms of function in the above description. Whether these functions are performed in electronic hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered to exceed the scope of the present invention.

Claims

1. A temperature control method for a solid phase collection device, characterized in that: Applicable to a solid phase collection device, the solid phase collection device includes a column tube, an adsorbent, an eluent container, a pump and a control module, the column tube is filled with the adsorbent, the eluent container is connected to the column tube, the pump is arranged between the eluent container and the column tube, the pump is used to control the flow rate and pressure of the eluent, and the control module is connected to the pump for controlling the working state of the pump; The method comprises: Acquiring a first temperature value of the sample to be processed at the column tube inlet, and determining a sample temperature adjustment amount of the sample to be processed according to the first temperature value; After the adsorbent in the column tube completes adsorption of the sample to be processed, the flow rate, pressure value and second temperature value of the eluent at the column tube inlet are obtained; determining an eluent temperature adjustment amount of the eluent according to the second temperature value; determining a flow rate adjustment amount and a pressure adjustment amount of the eluent according to the temperature adjustment amount of the eluent; Based on the flow rate and pressure of the eluent, setting the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount; The temperature adjustment module is controlled according to the sample temperature adjustment amount to adjust the temperature of the sample to be processed, and the pump is controlled according to the working state of the pump to achieve temperature control of the solid phase collection device.

2. The temperature control method for a solid phase collection device according to claim 1, characterized in that: Determining a sample temperature adjustment amount of the sample to be processed according to the first temperature value includes: Preset sample temperature; determining a sample temperature difference between the first temperature value and the sample preset temperature; determining a sample temperature adjustment amount of the sample to be processed according to the sample temperature difference; The sample temperature adjustment amount is ∆T1=|Ty1-Ty0|, where Ty1 is the first temperature value and Ty0 is the preset temperature of the sample.

3. The temperature control method for a solid phase collection device according to claim 2, characterized in that: Determining a sample temperature adjustment amount of the sample to be processed according to the first temperature value further includes: When the first temperature value is greater than the preset temperature of the sample, cooling the sample to be processed; When the first temperature value is lower than the preset temperature of the sample, the sample to be processed is heated and adjusted.

4. The temperature control method for a solid phase collection device according to claim 1, characterized in that: Determining an eluent temperature adjustment amount of the eluent according to the second temperature value includes: determining a temperature difference of the eluent between the second temperature value and a preset temperature of the eluent; Presetting a first eluent temperature difference, a second eluent temperature difference, and a third eluent temperature difference, wherein the first eluent temperature difference, the second eluent temperature difference, and the third eluent temperature difference increase in sequence; setting an eluent temperature adjustment amount of the eluent according to a relationship between the eluent temperature difference and the first eluent temperature difference, the second eluent temperature difference, and the third eluent temperature difference; If the eluent temperature difference is less than the first eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the first preset temperature adjustment amount Ts1; If the eluent temperature difference is greater than or equal to the first eluent temperature difference, and the eluent temperature difference is less than the second eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the second preset temperature adjustment amount Ts2; If the eluent temperature difference is greater than or equal to the second eluent temperature difference, and the eluent temperature difference is less than the third eluent temperature difference, setting the eluent temperature adjustment amount of the eluent to the third preset temperature adjustment amount Ts3; If the eluent temperature difference is greater than or equal to the third eluent temperature difference, the eluent temperature adjustment amount of the eluent is set to a fourth preset temperature adjustment amount Ts4; wherein Ts1<Ts2<Ts3<Ts4.

5. The temperature control method for a solid phase collection device according to claim 4, characterized in that: Determining the flow rate adjustment amount and the pressure adjustment amount of the eluent according to the eluent temperature adjustment amount includes: If the eluent temperature adjustment amount of the eluent is the first preset temperature adjustment amount Ts1, the flow rate adjustment amount is set to the first preset flow rate adjustment amount V1, and the pressure adjustment amount is set to the first preset pressure adjustment amount P1; If the eluent temperature adjustment amount of the eluent is the second preset temperature adjustment amount Ts2, the flow rate adjustment amount is set to the second preset flow rate adjustment amount V2, and the pressure adjustment amount is set to the second preset pressure adjustment amount P2; If the eluent temperature adjustment amount of the eluent is the third preset temperature adjustment amount Ts3, the flow rate adjustment amount is set to the third preset flow rate adjustment amount V3, and the pressure adjustment amount is set to the third preset pressure adjustment amount P3; If the eluent temperature adjustment amount of the eluent is the fourth preset temperature adjustment amount Ts4, then the flow rate adjustment amount is set to the fourth preset flow rate adjustment amount V4, and the pressure adjustment amount is set to the fourth preset pressure adjustment amount P4; wherein V1<V2<V3<V4, P1<P2<P3<P4.

6. The temperature control method for a solid phase collection device according to claim 1, characterized in that: The method further comprises setting the working state of the pump according to the flow rate and pressure of the eluent and the flow rate adjustment amount and the pressure adjustment amount based on the flow rate and pressure of the eluent, comprising: determining a required flow rate of the eluent according to the flow rate of the eluent and the flow rate adjustment amount; determining the required pressure of the eluent according to the pressure of the eluent and the pressure adjustment amount; The working state of the pump is set according to the required flow rate and the required pressure.

7. The temperature control method for a solid phase collection device according to claim 6, characterized in that: Setting the working state of the pump according to the required flow rate and the required pressure includes: determining an initial motor speed of the pump according to the required flow rate; A first preset demand flow rate, a second preset demand flow rate and a third preset demand flow rate are preset and set, wherein the first preset demand flow rate, the second preset demand flow rate and the third preset demand flow rate increase in sequence; setting an initial motor speed of the pump according to a relationship between the required flow rate and the first preset required flow rate, the second preset required flow rate, and the third preset required flow rate; If the required flow rate is less than the first preset required flow rate, the initial motor speed of the pump is set to the first preset motor speed N1; If the required flow rate is greater than or equal to the first preset required flow rate, and the required flow rate is less than the second preset required flow rate, setting the initial motor speed of the pump to the second preset motor speed N2; If the required flow rate is greater than or equal to the second preset required flow rate, and the required flow rate is less than the third preset required flow rate, then setting the initial motor speed of the pump to the third preset motor speed N3; If the required flow rate is greater than or equal to the third preset required flow rate, the initial motor speed of the pump is set to a fourth preset motor speed N4; wherein N1 < N2 < N3 < N4.

8. The temperature control method for a solid phase collection device according to claim 7, characterized in that: Setting the working state of the pump according to the required flow rate and the required pressure also includes: After the initial motor speed of the pump is set to the i-th preset motor speed Ni according to the relationship between the required flow rate and the first preset required flow rate, the second preset required flow rate, and the third preset required flow rate, i=1, 2, 3, 4, the i-th preset motor speed Ni is adjusted according to the required pressure to obtain the final motor speed of the pump; Presetting a first preset demand pressure, a second preset demand pressure, and a third preset demand pressure, wherein the first preset demand pressure, the second preset demand pressure, and the third preset demand pressure increase in sequence; adjusting the i-th preset motor speed Ni according to the relationship between the demand pressure and the first preset demand pressure, the second preset demand pressure, and the third preset demand pressure to obtain a final motor speed of the pump; If the required pressure is less than the first preset required pressure, the first speed correction coefficient m1 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m1; If the demand pressure is greater than or equal to the first preset demand pressure and the demand pressure is less than the second preset demand pressure, then the second speed correction coefficient m2 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m2; If the demand pressure is greater than or equal to the second preset demand pressure and is less than the third preset demand pressure, the third speed correction coefficient m3 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m3; If the demand pressure is greater than or equal to the third preset demand pressure, the fourth speed correction coefficient m4 is selected to adjust the i-th preset motor speed Ni, so that the final motor speed of the pump is Ni×m4; wherein m1<m2<m3<m4.

9. A temperature control system for a solid phase collection device, used for applying the temperature control method for a solid phase collection device according to any one of claims 1 to 8, characterized in that: The system comprises: A temperature adjustment module, used for adjusting the temperature of the sample to be processed; an acquisition module, configured to acquire a first temperature value of the sample to be processed at the column tube inlet, and to acquire a flow rate, a pressure value, and a second temperature value of the eluent at the column tube inlet after the adsorbent in the column tube completes adsorption of the sample to be processed; a processing module, configured to determine a sample temperature adjustment amount of the sample to be processed according to the first temperature value, determine an eluent temperature adjustment amount of the eluent according to the second temperature value, and determine a flow rate adjustment amount and a pressure adjustment amount of the eluent according to the eluent temperature adjustment amount; a setting module, configured to set the working state of the pump according to the flow rate adjustment amount and the pressure adjustment amount based on the flow rate and pressure of the eluent; The control module is used to control the temperature adjustment module to adjust the temperature of the sample to be processed according to the sample temperature adjustment amount, and to control the pump according to the working state of the pump to achieve temperature control of the solid phase collection device.

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