Oil-in-water emulsion composition

Abstract

The present invention provides a transparent or translucent oil-in-water emulsion composition containing the following components (A), (B), (C), (D), (E) and (F): (A) ceramides; (B) an anionic surfactant selected from the group consisting of N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof; (C) a nonionic surfactant having an HLB of 10 or more; (D) dihydric alcohol with the carbon atom number of 6-10; (E) a diol having 5 or less carbon atoms; and (F) water.

Description

Technical Field

[0001] The present invention relates to an oil-in-water emulsion composition. Background Art

[0002] Lipids called intercellular lipids of horny cells exist in the intercellular spaces of horny cells that make up the outermost layer of the skin. Ceramides, which account for about 50% of the intercellular lipids of horny cells, are closely related to rough skin and dry skin, and it is known that the state of the stratum corneum can be improved by supplementing ceramides topically.

[0003] However, when solid lipids such as ceramides are formulated into cosmetics, it is difficult to achieve stabilization in the preparation because of the high crystallinity and high melting point of the solid lipids. Therefore, research is being conducted on technologies for stably formulating these.

[0004] For example, Patent Document 1 describes a lipid particle dispersion containing one or more selected from sterols and their derivatives, lipids such as ceramides that are solid or semi-solid at 25°C, and an anionic surfactant, which does not crystallize solid lipids such as ceramides and can be stably emulsified and dispersed in the form of particles.

[0005] Patent Document 2 describes a composition in the form of a nanoemulsion or microemulsion containing a nonionic surfactant with an HLB of 8 to 14, a ceramide compound, and vitamin B3 or its derivative, which can enhance or improve the penetration of the ceramide compound into the skin.

[0006] (Patent Document 1) Japanese Patent Laid-Open No. 2019-119742

[0007] (Patent Document 2) Japanese Patent Laid-Open No. 2018-87149 Summary of the Invention

[0008] The present invention relates to a transparent or semi-transparent oil-in-water emulsion composition containing the following components (A), (B), (C), (D), (E) and (F):

[0009] (A) Ceramides

[0010] (B) An anionic surfactant selected from N-acyl-N-alkyl taurine, N-acyl-L-glutamic acid, and their salts

[0011] (C) A nonionic surfactant with an HLB of 10 or more

[0012] (D) A diol having 6 to 10 carbon atoms

[0013] (E) A diol having 5 or fewer carbon atoms

[0014] (F) Water. Detailed implementation mode

[0015] For the compositions of Patent Document 1 and Patent Document 2, even if they are transparent at normal temperature just after production, if they are frozen and then thawed, cloudiness due to aggregation of emulsion particles can be confirmed. To prevent this phenomenon, it is necessary to formulate polyhydric alcohols or thickeners, but this causes problems in limiting the feel of use.

[0016] The present inventors have found that by using ceramides, specific anionic surfactants, nonionic surfactants, dihydric alcohols having 6 to 10 carbon atoms and dihydric alcohols having 5 or less carbon atoms in combination, and stably emulsifying and dispersing ceramides in the form of fine particles by a general process, an oil-in-water type emulsified composition having a transparent or semi-transparent appearance can be obtained, which has excellent storage stability at low and high temperatures, prevents deterioration of the appearance accompanying freeze-thawing, and imparts a refreshing feeling and a smooth feeling to the skin after coating.

[0017] The oil-in-water type emulsified composition of the present invention is a composition having a transparent or semi-transparent appearance that can stably emulsify and disperse ceramides in the form of fine particles by a general process.

[0018] As the ceramides as component (A) used in the present invention, not only natural ceramides such as ceramide 1, 2, 3, 4, 5, 6, 7 and sphingosine derivatives such as phytosphingosine can be cited, but also ceramide-like structural substances described in Japanese Patent Laid-Open No. Sho 62-228048, Sho 63-216812, Sho 63-227513, Sho 64-29347, Sho 64-31752, Hei 8-319263, etc. can be listed. As the ceramide-like structural substances, specifically, from the viewpoints of improving the smoothness of the skin after coating and improving the moisturizing effect, the compounds represented by the following general formulas (1) and (2) can be cited.

[0019]

[0020] [In the formula, R 1b represents a hydrocarbon group having 10 to 26 carbon atoms, and R 2b represents a hydrocarbon group having 9 to 25 carbon atoms; X represents -(CH2) n -(wherein, n represents an integer of 2 to 6).]

[0021]

[0022] (In the formula, R 1 and R 2are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may or may not be hydroxylated; R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or 2,3-dihydroxypropoxy group. Wherein, when R 3 is a single bond, R 4 is a hydrogen atom.)

[0023] In addition, in the above general formulas (1) and (2), the hydrocarbon group is preferably an alkyl group or an alkenyl group.

[0024] Examples of the compound of the general formula (1) include N-(hexadecyloxyhydroxypropyl)-N-hydroxyethyl hexadecanamide; examples of the compound of the general formula (2) include long-chain dibasic acid bis(3-methoxypropanamide).

[0025] The compound represented by the general formula (1) is a pseudo-ceramide, a functional component of ceramide, capable of supplementing the function of ceramide and improving the skin condition (such as water content, etc.).

[0026] Regarding the component (A), from the viewpoints of improving the smoothness of the skin after coating and enhancing the moisturizing effect, it is preferably composed of one or more selected from natural ceramide, sphingosine, and the compounds represented by the above general formulas (1) and (2), more preferably composed of one or more selected from natural ceramide, sphingosine, and the compound represented by the above general formula (1), further preferably composed of one or more selected from natural ceramide, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethyl hexadecanamide, and even more preferably contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethyl hexadecanamide.

[0027] Regarding the component (A), one or more can be used. From the viewpoint of improving the smoothness of the skin after coating, its content in the total composition is preferably 0.00001% by mass or more, more preferably 0.001% by mass or more, further preferably 0.005% by mass or more, even more preferably 0.03% by mass or more, particularly preferably 0.125% by mass or more, and preferably 0.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.35% by mass or less, even more preferably 0.27% by mass or less, and particularly preferably 0.23% by mass or less.

[0028] In addition, in the total composition, the content of component (A) is preferably 0.00001 to 0.5% by mass, more preferably 0.001 to 0.4% by mass, still more preferably 0.005 to 0.35% by mass, still more preferably 0.03 to 0.27% by mass, and particularly preferably 0.125 to 0.23% by mass.

[0029] The anionic surfactant of component (B) is selected from N-acyl-N-alkyl taurine, N-acyl-L-glutamic acid, and their salts.

[0030] N-acyl-N-alkyl taurine and its salts are preferably N-acyl-N-methyl taurine and its salts, and examples thereof include N-myristoyl-N-methyl taurine, N-lauroyl-N-methyl taurine, N-stearoyl-N-methyl taurine, and their salts. In addition, the salt of N-acyl-N-alkyl taurine is preferably a sodium salt, and examples thereof include sodium N-myristoyl-N-methyl taurine, sodium N-lauroyl-N-methyl taurine, and sodium N-stearoyl-N-methyl taurine. Among these, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, and improving the storage stability at high temperatures, it is preferable to contain one or more selected from N-lauroyl-N-methyl taurine, N-stearoyl-N-methyl taurine, and their salts, more preferably to contain N-stearoyl-N-methyl taurine and its salts, and still more preferably to contain sodium N-stearoyl-N-methyl taurine.

[0031] Regarding N-acyl-L-glutamic acid and its salts, examples thereof include N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, N-myristoyl-L-glutamic acid, and their salts. Among these, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, and improving the storage stability at high temperatures, it is preferable to contain one or more selected from N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, and their salts, and more preferably to contain N-stearoyl-L-glutamic acid and its salts.

[0032] Regarding component (B), from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, and improving the storage stability at high temperatures, it is preferable to contain N-acyl-N-methyl taurine and its salts, more preferably to contain one or more selected from N-lauroyl-N-methyl taurine, N-stearoyl-N-methyl taurine, and their salts, still more preferably to contain N-stearoyl-N-methyl taurine and its salts, and further preferably sodium N-stearoyl-N-methyl taurine.

[0033] Regarding component (B), one or more than two kinds can be used. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, and improving the smooth feeling of the skin after coating, its content in the total composition is preferably 0.001% by mass or more, more preferably 0.015% by mass or more, further preferably 0.023% by mass or more, further more preferably 0.028% by mass or more, particularly preferably 0.048% by mass or more, and preferably 0.5% by mass or less, more preferably 0.35% by mass or less, further preferably 0.2% by mass or less, further more preferably 0.09% by mass or less, particularly preferably 0.07% by mass or less. In addition, in the total composition, the content of component (B) is preferably 0.001 to 0.5% by mass, more preferably 0.015 to 0.35% by mass, further preferably 0.023 to 0.2% by mass, further more preferably 0.028 to 0.09% by mass, particularly preferably 0.048 to 0.07% by mass.

[0034] In the present invention, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, the mass ratio (A) / (B) of component (A) to component (B) is preferably 2 or more, more preferably 2.2 or more, further preferably 2.7 or more, further more preferably 2.9 or more, and preferably 7 or less, more preferably 6 or less, further preferably 5 or less, further more preferably 4.5 or less. In addition, the mass ratio (A) / (B) of component (A) to component (B) is preferably 2 to 7, more preferably 2.2 to 6, further preferably 2.7 to 5, further more preferably 2.9 to 4.5.

[0035] Regarding the nonionic surfactant of component (C), its HLB is 10 or more. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, the HLB is preferably 11 to 16, and more preferably 12 to 15.

[0036] Herein, HLB (Hydrophilic-Lipophilic Balance) represents the molecular weight of the hydrophilic group part in the total molecular weight of the surfactant, and is obtained by the Griffin formula. In addition, when composed of two or more nonionic surfactants, the HLB of the mixed surfactant is obtained as follows. The HLB of the mixed surfactant is the arithmetic average of the HLB values of the respective nonionic surfactants based on the blending ratio.

[0037] Mixing HLB = Σ(HLBx × Wx) / ΣWx

[0038] HLBx represents the HLB value of the nonionic surfactant X.

[0039] Wx represents the mass (g) of the nonionic surfactant X having the HLBx value.

[0040] Examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkanol ether, polyglycerol fatty acid ester, sucrose fatty acid ester, etc. Among these, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, it is preferably containing one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid ester, and more preferably containing polyoxyethylene hydrogenated castor oil.

[0041] In addition, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, in polyoxyethylene hydrogenated castor oil, the average addition mole number of the polyoxyethylene chain constituting the polyoxyethylene hydrogenated castor oil is preferably 25 to 100, more preferably 35 to 85, further preferably 45 to 75, further more preferably 55 to 65, and particularly preferably 60.

[0042] From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, in polyoxyethylene sorbitan fatty acid ester, the average addition mole number of the polyoxyethylene chain constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 30, more preferably 15 to 25, and further preferably 20. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing the appearance deterioration accompanying freeze-thaw, in polyoxyethylene sorbitan fatty acid ester, the number of carbon atoms of the alkyl group constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 25, more preferably 16 to 20, and further preferably 18.

[0043] Regarding the nonionic surfactant of component (C), one or more than two kinds can be used in combination. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, enhancing the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, and improving the skin fresh feeling after coating, its content is preferably 0.1% by mass or more, more preferably 0.13% by mass or more, further preferably 0.2% by mass or more, still more preferably 0.26% by mass or more, and is preferably 4% by mass or less, more preferably 2% by mass or less, further preferably 0.7% by mass or less, still more preferably 0.35% by mass or less in the total composition. Additionally, in the total composition, the content of component (C) is preferably 0.1 - 4% by mass, more preferably 0.13 - 2% by mass, further preferably 0.2 - 0.7% by mass, still more preferably 0.26 - 0.35% by mass.

[0044] Component (D) is a diol having 6 to 10 carbon atoms.

[0045] Examples of component (D) include triethylene glycol, dipropylene glycol, tripropylene glycol, etc., and dipropylene glycol is preferably contained.

[0046] Regarding component (D), one or more than two kinds can be used in combination. From the viewpoints of dissolving ceramides during the manufacturing process, making ceramides into fine particles, improving the transparency of the appearance, enhancing the storage stability at low temperatures, and improving the skin fresh feeling after coating, its content is preferably 0.1% by mass or more, more preferably 0.13% by mass or more, further preferably 0.15% by mass or more, still more preferably 0.3% by mass or more, and is preferably 10% by mass or less, more preferably 6% by mass or less, further preferably 3% by mass or less, still more preferably 1% by mass or less in the total composition. Additionally, in the total composition, the content of component (D) is preferably 0.1 - 10% by mass, more preferably 0.13 - 6% by mass, further preferably 0.15 - 3% by mass, still more preferably 0.3 - 1% by mass.

[0047] In the present invention, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, improving the refreshing feeling of the skin after coating, and improving the smooth feeling of the skin after coating, the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 or more, more preferably 0.01 or more, further preferably 0.02 or more, still further preferably 0.06 or more, and preferably 7 or less, more preferably 1 or less, further preferably 0.5 or less, still further preferably 0.2 or less. Additionally, the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 to 7, more preferably 0.01 to 1, further preferably 0.02 to 0.5, still further preferably 0.06 to 0.2.

[0048] Component (E) is a diol having 5 or less carbon atoms.

[0049] Examples of component (E) include ethylene glycol, diethylene glycol, propylene glycol, 1,3-butanediol, etc. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, and improving the refreshing feeling of the skin after coating, it is preferably to contain one or more selected from propylene glycol and 1,3-butanediol, and more preferably to contain 1,3-butanediol.

[0050] Regarding component (E), one kind can be used or two or more kinds can be used in combination. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, and improving the refreshing feeling of the skin after coating, its content in the total composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, further preferably 1.7% by mass or more, still further preferably 2% by mass or more, and preferably 10% by mass or less, more preferably 7.5% by mass or less, further preferably 2.7% by mass or less, still further preferably 4% by mass or less. Additionally, in the total composition, the content of component (E) is preferably 0.1 to 10% by mass, more preferably 0.5 to 7.5% by mass, further preferably 1.7 to 2.7% by mass, still further preferably 2 to 4% by mass.

[0051] In the present invention, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, and improving the refreshing feeling of the skin after coating, in the total composition, the total content (D)+(E) of component (D) and component (E) is preferably 0.1% by mass or more, more preferably 1% by mass or more, further preferably 2.3% by mass or more, further more preferably 2.8% by mass or more, particularly preferably 3% by mass or more, and is preferably 15% by mass or less, more preferably 12% by mass or less, further preferably 9% by mass or less, further more preferably 5.5% by mass or less, particularly preferably 5% by mass or less. In addition, in the total composition, the total content (D)+(E) of component (D) and component (E) is preferably 0.1 to 15% by mass, more preferably 1 to 12% by mass, further preferably 2.3 to 9% by mass, further more preferably 2.8 to 5.5% by mass, particularly preferably 3 to 5% by mass.

[0052] In the present invention, from the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, suppressing the appearance deterioration accompanying freeze-thawing, improving the refreshing feeling of the skin after coating, and improving the smooth feeling of the skin after coating, the mass ratio (D) / (E) of component (D) to component (E) is preferably 0.01 or more, more preferably 0.02 or more, further preferably 0.04 or more, further more preferably 0.06 or more, more preferably 0.08 or more, further preferably 0.2 or more, and is preferably 10 or less, more preferably 5 or less, further preferably 2 or less, further more preferably 1.4 or less, particularly preferably 1 or less, further particularly preferably 0.56 or less. In addition, the mass ratio (D) / (E) of component (D) to component (E) is preferably 0.01 to 10, more preferably 0.02 to 5, further preferably 0.04 to 2, further more preferably 0.06 to 1.4, particularly preferably 0.08 to 1, further particularly preferably 0.2 to 0.56.

[0053] In the present invention, from the viewpoints of improving the refreshing feeling of the skin after coating and improving the stability at high temperatures, in the total composition, the content of component (F) water is preferably 50% by mass or more, more preferably 60%, further preferably 70% by mass or more, and is preferably 99% by mass or less, more preferably 95% by mass or less, further preferably 90% by mass or less. In addition, in the total composition, the content of component (F) water is preferably 50 to 99% by mass, more preferably 60 to 95% by mass, further preferably 70 to 90% by mass.

[0054] The oil-in-water emulsion composition of the present invention further contains (G) basic amino acids, which can make ceramides into fine particles, improve the transparency of the appearance, improve the storage stability at high temperatures, and inhibit the appearance deterioration accompanying freeze-thawing.

[0055] Examples of the basic amino acids include arginine, lysine, histidine, etc. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and inhibiting the appearance deterioration accompanying freeze-thawing, arginine is preferably contained.

[0056] Regarding the component (G), one kind can be used, or two or more kinds can be used in combination. From the viewpoints of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and inhibiting the appearance deterioration accompanying freeze-thawing, its content in the total composition is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, further preferably 0.05% by mass or more, further more preferably 0.1% by mass or more, and preferably 1% by mass or less, more preferably 0.8% by mass or less, further preferably 0.5% by mass or less, further more preferably 0.2% by mass or less. In addition, in the total composition, the content of the component (G) is preferably 0.01 to 1% by mass, more preferably 0.02 to 0.8% by mass, further preferably 0.05 to 0.5% by mass, further more preferably 0.1 to 0.2% by mass.

[0057] In addition to the above components, the oil-in-water emulsion composition of the present invention may contain components commonly used in cosmetics, such as: oil components other than the above, surfactants other than the above, water-soluble polymers, antioxidants, fragrances, preservatives, pH adjusters, blood circulation promoters, cooling agents, antiperspirants, bactericides, skin activators, moisturizers, refreshing agents, colorants, etc.

[0058] For the oil-in-water emulsion composition of the present invention, from the viewpoint of the feeling in use, the content of the oil component other than the component (A) is preferably 15% by mass or less, more preferably 5% by mass or less, further preferably 1%, further more preferably 0.5% by mass or less, and more preferably 0.1% by mass or less.

[0059] The oil-in-water emulsion composition of the present invention can be produced by a conventional method.

[0060] For example, the components (A) to (E) and other oily components are heated and stirred to prepare a uniformly dissolved oily component dissolved phase, and an aqueous phase in which the aqueous component containing the component (F) has been heated and mixed is added to the oily component dissolved phase and stirred. Then, cooling is carried out, whereby an oil-in-water emulsion composition can be obtained.

[0061] The appearance of the oil-in-water emulsion composition of the present invention is transparent or translucent.

[0062] The so-called "transparent" means that the transmittance relative to pure water is 70% or more.

[0063] In addition, the so-called "translucent" means that the transmittance relative to pure water is less than 70% and 40% or more.

[0064] In the present invention, the transmittance is calculated as follows: when the transmittance of pure water is set to 100%, the ratio of light with a wavelength of 550 nm penetrating the oil-in-water emulsion composition at 25°C.

[0065] In addition, the oil-in-water emulsion composition of the present invention has excellent storage stability at low and high temperatures, can prevent the appearance deterioration accompanied by freeze-thawing, and can impart a refreshing feeling and a smooth feeling to the skin after coating.

[0066] In addition, for the oil-in-water emulsion composition of the present invention, from the viewpoints of a transparent or translucent appearance and improved storage stability at high temperatures, the average particle diameter of the emulsion particles is preferably 10 nm or more, more preferably 40 nm or more, further preferably 60 nm or more, still further preferably 90 nm or more, and preferably 200 nm or less, more preferably 170 nm or less, further preferably 135 nm or less, still further preferably 110 nm or less. In addition, the average particle diameter of the emulsion particles is preferably 10 to 200 nm, more preferably 40 to 170 nm, further preferably 60 to 135 nm, still further preferably 90 to 110 nm.

[0067] In the present invention, the average particle diameter of the emulsion particles is measured by diluting various oil-in-water emulsion compositions 20 times and using a Zetasizer Nano Z manufactured by Malvern.

[0068] From the viewpoint of improving the refreshing feeling of the skin after coating, the viscosity of the oil-in-water emulsion composition of the present invention at 25°C is preferably 1 mPa·s or more, more preferably 2 mPa·s or more, particularly preferably 5 mPa·s or more, and preferably 50 mPa·s or less, more preferably 30 mPa·s or less, particularly preferably 20 mPa·s or less. In addition, the viscosity at 25°C is preferably 1 to 50 mPa·s, more preferably 2 to 30 mPa·s, particularly preferably 5 to 20 mPa·s.

[0069] In the present invention, the viscosity is measured at 25°C using a TVB-10 type viscometer, rotor 1, 60 rpm, for 1 minute.

[0070] The oil-in-water emulsion composition of the present invention is suitable as an oil-in-water emulsified cosmetic. For example, it can be used as skin cosmetics such as skin care cosmetics like lotion, emulsion, essence, etc., and is suitable as a transparent or semi-transparent lotion.

[0071] Regarding the above embodiments, the present invention further discloses the following compositions and the like.

[0072] <1>A transparent or semi-transparent oil-in-water emulsion composition, which contains the following components (A), (B), (C), (D), (E) and (F):

[0073] (A) Ceramides;

[0074] (B) An anionic surfactant selected from N-acyl-N-alkyl taurines, N-acyl-L-glutamic acids, and their salts;

[0075] (C) A nonionic surfactant with an HLB of 10 or more;

[0076] (D) A diol having 6 to 10 carbon atoms;

[0077] (E) A diol having 5 or less carbon atoms;

[0078] (F) Water.

[0079] <2>The oil-in-water emulsion composition according to the above <1>, wherein the ceramides of component (A) are preferably one or more selected from natural ceramides, sphinganols, and the compounds represented by the following general formulas (1) and (2),

[0080]

[0081] In the formula, R 1b represents a hydrocarbon group having 10 to 26 carbon atoms; R 2b represents a hydrocarbon group having 9 to 25 carbon atoms; X represents -(CH2) n -, where n is an integer of 2 to 6;

[0082]

[0083] In the formula, R 1 is the same as or different from R 2 and each represents a hydroxylated or non-hydroxylated hydrocarbon group having 1 to 40 carbon atoms; R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or 2,3-dihydroxypropoxy group, where when R 3 is a single bond, R 4is a hydrogen atom;

[0084] More preferably, it contains one or more selected from natural ceramides, sphinganols, and the compounds represented by the above general formula (1); Further preferably, it contains one or more selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide; Even more preferably, it contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide.

[0085] <3> The oil-in-water emulsion composition as described in <1> or <2> above, wherein, in the total composition, the content of component (A) is preferably 0.00001% by mass or more, more preferably 0.001% by mass or more, further preferably 0.005% by mass or more, even more preferably 0.03% by mass or more, particularly preferably 0.125% by mass or more, and preferably 0.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.35% by mass or less, even more preferably 0.27% by mass or less, particularly preferably 0.23% by mass or less.

[0086] <4> The oil-in-water emulsion composition as described in any one of <1> to <3> above, wherein component (B) preferably contains N-acyl-N-methyltaurine and their salts; More preferably, it contains one or more selected from N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine, and their salts; Further preferably, it contains N-stearoyl-N-methyltaurine and its salts; Even more preferably, it contains sodium N-stearoyl-N-methyltaurine.

[0087] <5> The oil-in-water emulsion composition as described in any one of <1> to <4> above, wherein, in the total composition, the content of component (B) is preferably 0.001% by mass or more, more preferably 0.015% by mass or more, further preferably 0.023% by mass or more, even more preferably 0.028% by mass or more, particularly preferably 0.048% by mass or more, and preferably 0.5% by mass or less, more preferably 0.35% by mass or less, further preferably 0.2% by mass or less, even more preferably 0.09% by mass or less, particularly preferably 0.07% by mass or less.

[0088] <6> The oil-in-water emulsion composition as described in any one of <1> to <5> above, wherein the mass ratio of component (A) to component (B), (A) / (B), is preferably 2 or more, more preferably 2.2 or more, further preferably 2.7 or more, even more preferably 2.9 or more, and preferably 7 or less, more preferably 6 or less, further preferably 5 or less, even more preferably 4.5 or less.

[0089] <7> The oil-in-water type emulsified composition according to any one of <1> to <6> above, wherein, with respect to component (C), the HLB is preferably from 11 to 16, more preferably from 12 to 15.

[0090] <8> The oil-in-water type emulsified composition according to any one of <1> to <7> above, wherein component (C) is preferably one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters, more preferably contains polyoxyethylene hydrogenated castor oil.

[0091] <9> The oil-in-water type emulsified composition according to any one of <1> to <8> above, wherein, in the total composition, the content of component (C) is preferably 0.1% by mass or more, more preferably 0.13% by mass or more, further preferably 0.2% by mass or more, further more preferably 0.26% by mass or more, and preferably 4% by mass or less, more preferably 2% by mass or less, further preferably 0.7% by mass or less, further more preferably 0.35% by mass or less.

[0092] <10> The oil-in-water type emulsified composition according to any one of <1> to <9> above, wherein component (D) preferably contains dipropylene glycol.

[0093] <11> The oil-in-water type emulsified composition according to any one of <1> to <10> above, wherein, in the total composition, the content of component (D) is preferably 0.1% by mass or more, more preferably 0.13% by mass or more, further preferably 0.15% by mass or more, further more preferably 0.3% by mass or more, and preferably 10% by mass or less, more preferably 6% by mass or less, further preferably 3% by mass or less, further more preferably 1% by mass or less.

[0094] <12> The oil-in-water type emulsified composition according to any one of <1> to <11> above, wherein the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 or more, more preferably 0.01 or more, further preferably 0.02 or more, further more preferably 0.06 or more, and preferably 7 or less, more preferably 1 or less, further preferably 0.5 or less, further more preferably 0.2 or less.

[0095] <13> The oil-in-water type emulsified composition according to any one of <1> to <12> above, wherein component (E) preferably contains one or more selected from propylene glycol and 1,3-butanediol, more preferably contains 1,3-butanediol.

[0096] <14> The oil-in-water type emulsified composition according to any one of <1> to <13> above, wherein in the total composition, the content of component (E) is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, further preferably 1.7% by mass or more, still more preferably 2% by mass or more, and preferably 10% by mass or less, more preferably 7.5% by mass or less, further preferably 2.7% by mass or less, still more preferably 4% by mass or less.

[0097] <15> The oil-in-water type emulsified composition according to any one of <1> to <14> above, wherein in the total composition, the total content of components (D) and (E), (D)+(E), is preferably 0.1% by mass or more, more preferably 1% by mass or more, further preferably 2.3% by mass or more, still more preferably 2.8% by mass or more, particularly preferably 3% by mass or more, and preferably 15% by mass or less, more preferably 12% by mass or less, further preferably 9% by mass or less, still more preferably 5.5% by mass or less, particularly preferably 5% by mass or less.

[0098] <16> The oil-in-water type emulsified composition according to any one of <1> to <15> above, wherein the mass ratio of component (D) to component (E), (D) / (E), is preferably 0.01 or more, more preferably 0.02 or more, further preferably 0.04 or more, still more preferably 0.06 or more, particularly preferably 0.08 or more, further particularly preferably 0.2 or more, and preferably 10 or less, more preferably 5 or less, further preferably 2 or less, still more preferably 1.4 or less, particularly preferably 1 or less, further particularly preferably 0.56 or less.

[0099] <17> The oil-in-water type emulsified composition according to any one of <1> to <16> above, wherein in the total composition, the content of component (F), water, is preferably 50% by mass or more, more preferably 60%, further preferably 70% by mass or more, and preferably 99% by mass or less, more preferably 95% by mass or less, further preferably 90% by mass or less.

[0100] <18> The oil-in-water type emulsified composition according to any one of <1> to <17> above preferably further contains (G) basic amino acids, and more preferably contains arginine.

[0101] <19> The oil-in-water type emulsified composition as described in <18> above, wherein, in the total composition, the content of component (G) is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, still more preferably 0.05% by mass or more, further more preferably 0.1% by mass or more, and preferably 1% by mass or less, more preferably 0.8% by mass or less, still more preferably 0.5% by mass or less, further more preferably 0.2% by mass or less.

[0102] <20> The oil-in-water type emulsified composition as described in any one of <1> to <19> above, wherein the content of the oil component other than component (A) is preferably 15% by mass or less, more preferably 5% by mass or less, still more preferably 1% by mass, further more preferably 0.5% by mass or less, particularly preferably 0.1% by mass or less.

[0103] <21> The oil-in-water type emulsified composition as described in any one of <1> to <20> above, wherein the average particle diameter of the emulsified particles is preferably 10 nm or more, more preferably 40 nm or more, still more preferably 60 nm or more, further more preferably 90 nm or more, and preferably 200 nm or less, more preferably 170 nm or less, still more preferably 135 nm or less, further more preferably 110 nm or less.

[0104] <22> The oil-in-water type emulsified composition as described in any one of <1> to <21> above, wherein the viscosity of the oil-in-water type emulsified composition at 25 °C is preferably 1 mPa·s or more, more preferably 2 mPa·s or more, still more preferably 5 mPa·s or more, and preferably 50 mPa·s or less, more preferably 30 mPa·s or less, still more preferably 20 mPa·s or less.

[0105] <23> The oil-in-water type emulsified composition as described in any one of <1> to <22> above, and the oil-in-water type emulsified composition is preferably an oil-in-water type emulsified cosmetic, more preferably an oil-in-water type emulsified skin cosmetic.

[0106] <24> A transparent or semi-transparent oil-in-water type emulsified composition, which contains the following components (A), (B), (C), (D), (E) and (F).

[0107] (A) Ceramides: 0.00001 to 0.5% by mass;

[0108] (B) Anionic surfactants selected from N-acyl-N-alkyltaurines, N-acyl-L-glutamic acids, and salts thereof: 0.001 to 0.5% by mass;

[0109] (C) Nonionic surfactants with an HLB of 10 or more: 0.1 to 4% by mass;

[0110] (D) A diol having 6 to 10 carbon atoms: 0.1 to 10% by mass;

[0111] (E) A diol having 5 or fewer carbon atoms: 0.1 to 10% by mass;

[0112] (F) Water.

[0113] <25> A transparent or translucent oil-in-water type emulsified composition, containing the following components (A), (B), (C), (D), (E) and (F),

[0114] (A) N-(hexadecyloxypropyl)-N-hydroxyethyl hexadecanamide: 0.00001 to 0.5% by mass;

[0115] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.5% by mass;

[0116] (C) Polyoxyethylene hydrogenated castor oil with an HLB of 12 to 15: 0.1 to 4% by mass;

[0117] (D) Dipropylene glycol: 0.1 to 10% by mass;

[0118] (E) 1,3-Butanediol: 0.1 to 10% by mass;

[0119] (F) Water.

[0120] <26> A transparent or translucent oil-in-water type emulsified composition, containing the following components (A), (B), (C), (D), (E) and (F),

[0121] (A) N-(hexadecyloxypropyl)-N-hydroxyethyl hexadecanamide: 0.03 to 0.35% by mass;

[0122] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.2% by mass;

[0123] (C) Polyoxyethylene hydrogenated castor oil with an HLB of 12 to 15: 0.13 to 4% by mass;

[0124] (D) Dipropylene glycol: 0.15 to 10% by mass;

[0125] (E) 1,3-Butanediol: 0.5 to 10% by mass;

[0126] (F) Water.

[0127] <27> A transparent or translucent oil-in-water type emulsified composition, containing the following components (A), (B), (C), (D), (E), (F) and (G),

[0128] (A) Ceramide: 0.00001 to 0.5% by mass;

[0129] (B) Anionic surfactant selected from N-acyl-N-alkyl taurine, N-acyl-L-glutamic acid, and their salts: 0.001 to 0.5% by mass;

[0130] (C) Nonionic surfactant with an HLB of 10 or more: 0.1 to 4% by mass;

[0131] (D) Diol having 6 to 10 carbon atoms: 0.1 to 10% by mass;

[0132] (E) Diol having 5 or fewer carbon atoms: 0.1 to 10% by mass;

[0133] (F) Water;

[0134] (G) Basic amino acid: 0.01 to 1% by mass.

[0135] <28> A transparent or translucent oil-in-water type emulsified composition, containing the following components (A), (B), (C), (D), (E), (F) and (G),

[0136] (A) N-(hexadecyloxypropyl)-N-hydroxyethyl hexadecanamide: 0.00001 to 0.5% by mass;

[0137] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.5% by mass;

[0138] (C) Polyoxyethylene hydrogenated castor oil with an HLB of 12 to 15: 0.1 to 4% by mass;

[0139] (D) Dipropylene glycol: 0.1 to 10% by mass;

[0140] (E) 1,3-Butanediol: 0.1 to 10% by mass;

[0141] (F) Water;

[0142] (G) Arginine: 0.01 to 1% by mass.

[0143] <29> A transparent or translucent oil-in-water type emulsified composition, containing the following components (A), (B), (C), (D), (E), (F) and (G),

[0144] (A) N-(hexadecyloxypropyl)-N-hydroxyethyl hexadecanamide: 0.03 to 0.35% by mass;

[0145] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.2% by mass;

[0146] (C) Polyoxyethylene hydrogenated castor oil with an HLB of 12 to 15: 0.13 to 4% by mass;

[0147] (D) Dipropylene glycol: 0.15 to 10% by mass;

[0148] (E) 1,3-Butanediol: 0.5 to 10% by mass;

[0149] (F) Water;

[0150] (G) Arginine: 0.05 to 0.5% by mass.

[0151] <30>A transparent or semi-transparent oil-in-water type emulsified composition, which contains the following components (A), (B), (C), (D), (E) and (F),

[0152] (A) Ceramides: 0.005 to 0.35% by mass;

[0153] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.2% by mass;

[0154] (C) Polyoxyethylene hydrogenated castor oil with an HLB of 12 to 15: 0.13 to 4% by mass;

[0155] (D) Dipropylene glycol: 0.15 to 6% by mass;

[0156] (E) 1,3-Butanediol: 0.5 to 10% by mass;

[0157] (F) Water,

[0158] Moreover, the total content of components (D) and (E), (D)+(E), is 1 to 12% by mass.

[0159] <31>A transparent or semi-transparent oil-in-water type emulsified composition, which contains the following components (A), (B), (C), (D), (E) and (F),

[0160] (A) Ceramides: 0.005 to 0.35% by mass;

[0161] (B) Sodium N-stearoyl-N-methyl taurate: 0.001 to 0.2% by mass;

[0162] (C) One or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters with an HLB of 12 to 15: 0.13 to 4% by mass;

[0163] (D) Dipropylene glycol: 0.15 to 6% by mass;

[0164] (E) 1,3-Butanediol: 0.5 to 10% by mass;

[0165] (F) Water.

[0166] <32> An oil-in-water type emulsified composition that is transparent or semi-transparent, which contains the following components (A), (B), (C), (D), (E) and (F),

[0167] (A) Ceramides: 0.005 to 0.35% by mass;

[0168] (B) Sodium N-stearoyl-N-methyltaurate: 0.001 to 0.2% by mass;

[0169] (C) A nonionic surfactant having an HLB of 12 to 15 selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters: 0.13 to 4% by mass;

[0170] (D) Dipropylene glycol: 0.15 to 6% by mass;

[0171] (E) 1,3-Butanediol: 0.5 to 10% by mass;

[0172] (F) Water,

[0173] Moreover, the total content of components (D) and (E), (D)+(E), is 1 to 12% by mass.

[0174] [Examples]

[0175] [Examples 1 to 15, Comparative Examples 1 to 4]

[0176] Manufacture an oil-in-water type emulsified composition (lotion) having the composition shown in Table 1, measure the emulsification particle size immediately after manufacture, and evaluate the storage stability (appearance, transmittance), refreshing feeling and smooth feeling of the skin after coating. The results are shown in Table 1 together.

[0177] (Manufacturing method)

[0178] Heat and stir components (A) to (E) and (G) at 85°C to prepare an oil-phase component dissolved phase. Stir and mix the remaining components at 85°C to obtain an aqueous phase. Add the aqueous phase to the oil-phase component dissolved phase, and cool while stirring to obtain an oil-in-water type emulsified composition.

[0179] (Evaluation method)

[0180] (1) Particle size (immediately after manufacture):

[0181] Immediately after the production, each oil-in-water emulsion composition was diluted 20 times, and the average particle size of the emulsified particles was measured using a Zetasizer Nano Z manufactured by Malvern.

[0182] (2) Storage stability (appearance):

[0183] 80 mL of each oil-in-water emulsion composition was placed in a 110 mL transparent glass container (Specification #11, Tokyo Glass Instruments Co., Ltd.), sealed, and stored at each storage temperature for each period.

[0184] -20℃ (store for 1 day)

[0185] -5℃ (store for 30 days)

[0186] 50℃ (store for 30 days)

[0187] Each oil-in-water emulsion composition immediately after production and after storage at each storage temperature was left at 25° C. for 24 hours, and its appearance was visually observed and evaluated according to the following criteria. A score of 2 or more was considered “acceptable”.

[0188] 3: Transparent and uniform single layer without precipitates.

[0189] 2: There is no precipitation when it is left at rest. When it is shaken lightly, a small amount of precipitation that can be visually confirmed appears, but there is no problem in actual use.

[0190] 1: Even in a static state, precipitates can be clearly identified.

[0191] (3) Storage stability (penetration rate):

[0192] Each oil-in-water emulsion composition was stored in the same manner as in (2), and then the penetration rate was measured. Storage was performed at -20°C and 50°C.

[0193] The transmittance was measured using an ultraviolet visible spectrophotometer (UV1800) manufactured by Shimadzu Corporation using light of a wavelength of 550 nm, and the proportion of the permeation into the oil-in-water emulsion composition (stock solution) was calculated, with the transmittance of pure water being 100%.

[0194] (4) Refreshing and smooth feeling of skin after application:

[0195] Three professional evaluators applied 60 mg of each oil-in-water emulsion composition on the back of the hand, spreading it into a circle with a diameter of 5 cm for 20 seconds. Then, the refreshing feeling and smoothness of the skin after 5 minutes were evaluated according to the following criteria. The results are expressed as the total score of the three evaluators.

[0196] (4-1) Refreshing feeling:

[0197] 5: Significantly refreshing.

[0198] 4: Refreshing.

[0199] 3: Slightly refreshing.

[0200] 2: Slightly sticky.

[0201] 1: Significantly sticky.

[0202] (4-2) Smoothness:

[0203] 5: Significantly smooth.

[0204] 4: Smooth.

[0205] 3: Slightly smooth.

[0206] 2: Not very smooth.

[0207] 1: Significantly not smooth.

[0208]

[0209] *1: N-(Hexadecyloxyhydroxypropyl)-N-hydroxyethyl hexadecanamide; Sphingolipid E (manufactured by Kao Corporation),

[0210] *2: Ceramide 2; CERAMIDE TIC-001 (manufactured by Takasago Perfumery Co., Ltd.),

[0211] *3: Sodium N-stearoyl-N-methyl taurate; NIKKOL SMT (manufactured by Nippon Surfactant Industry Co., Ltd.),

[0212] *4: N-Stearoyl-L-glutamic acid; AMISOFT HA-P (manufactured by Ajinomoto Co., Inc.),

[0213] *5: Polyoxyethylene hydrogenated castor oil (60 E.O.); EMANON CH-60 (manufactured by Kao Corporation) HLB14,

[0214] *6: Polyoxyethylene sorbitan monostearate (20 E.O.); RHEODOL TW-S120V (manufactured by Kao Corporation) HLB14.9

[0215] [Formulation Examples 1-2]

[0216] An oil-in-water type emulsified composition (lotion) having the composition shown in Table 2 was produced in the same manner as in Examples 1 to 15. Its appearance was transparent or semi-transparent, and the transmittance just after production was as shown in Table 2. All of these oil-in-water type emulsified compositions had the following characteristics: excellent storage stability at low and high temperatures, prevention of appearance deterioration accompanying freeze-thawing, and imparting a refreshing feeling and a smooth feeling to the skin after coating.

[0217] [Table 2]

[0218]

Claims

1. A transparent or semi-transparent oil-in-water type emulsified composition, wherein it contains the following components (A), (B), (C), (D), (E) and (F): (A) Ceramides; (B) An anionic surfactant selected from N-acyl-N-alkyl taurine, N-acyl-L-glutamic acid, and salts thereof; (C) A nonionic surfactant having an HLB of 10 or more; (D) A diol having 6 to 10 carbon atoms; (E) A diol having 5 or less carbon atoms; (F) Water.

2. The oil-in-water type emulsified composition according to claim 1, wherein the mass ratio (B) / (D) of component (B) to component (D) is 0.005 to 7.

3. The oil-in-water type emulsified composition according to claim 1 or 2, wherein the mass ratio (D) / (E) of component (D) to component (E) is 0.01 to 10.

4. The oil-in-water type emulsified composition according to any one of claims 1 to 3, wherein the content of component (D) is 0.1 to 10% by mass.

5. The oil-in-water type emulsified composition according to any one of claims 1 to 4, wherein component (C) contains one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters.

6. The oil-in-water type emulsified composition according to any one of claims 1 to 5, wherein it further contains (G) basic amino acids.

7. The oil-in-water type emulsified composition according to any one of claims 1 to 6, wherein the viscosity of the oil-in-water type emulsified composition at 25 °C is 1 to 50 mPa·s.

Images