Composite moxa stick containing exocarpium citri rubrum

Abstract

The invention relates to a composite moxa stick containing exocarpium citri rubrum, and belongs to the technical field of moxa sticks. The invention provides an exocarpium citri rubrum-containing composite moxa stick which is prepared from the following raw materials: exocarpium citri rubrum subjected to enzyme treatment, mint powder, moxa floss, elm bark glue liquid, radix salviae miltiorrhizae powder and uncaria rhynchophylla extract, and the various raw materials are compounded to obtain the composite moxa stick. And the non-volatile components can be dissociated from the moxa stick along with combustion of the moxa stick, enter the skin along with heat and are further absorbed in a transdermal manner, so that the traditional Chinese medicine has a very good treatment effect on hypertension caused by various reasons.

Description

Technical Field

[0001] The present invention belongs to the technical field of moxa sticks and relates to a compound moxa stick containing tangerine peel. Background Art

[0002] Moxa stick is a traditional Chinese medicine physiotherapy tool mainly made of mugwort. The application history of moxa stick is long and it is usually used in moxibustion therapy. By igniting the moxa stick, the generated warm heat and medicinal smoke act on specific acupoints of the body, thereby promoting blood circulation and enhancing the body's self-healing ability. The use of moxa stick is extensive and is applicable to aspects such as relieving pain, improving blood circulation, promoting digestion, and enhancing immunity.

[0003] At the present stage, moxa sticks are mainly made of dried mugwort leaves and usually take moxa floss as the core material. Moxa floss is a delicate powder formed after processing mugwort and has good combustibility and medicinal efficacy. The active ingredients in it can release smoke and heat after heating, achieving the effect of stimulating meridians and warming and dredging qi and blood. However, at the present stage, although moxibustion can relieve some pain symptoms, its auxiliary treatment effect for some chronic diseases such as hypertension is limited and further research is needed. Summary of the Invention

[0004] The purpose of the present invention is to provide a compound moxa stick containing tangerine peel. The compound moxa stick of the present invention is prepared by compounding multiple raw materials. When in use, the volatile components in the drug components will volatilize, and the non-volatile components can be released from the moxa stick along with the combustion of the moxa stick, enter the skin along with the heat force and then be absorbed through the skin, and has a good therapeutic effect on hypertension caused by various reasons.

[0005] The purpose of the present invention can be achieved by the following technical solutions:

[0006] A compound moxa stick containing tangerine peel, and the preparation method of the compound moxa stick containing tangerine peel comprises the following steps:

[0007] Step 1: Prepare tangerine peel after enzyme treatment, mint powder, salvia miltiorrhiza powder, uncaria rhynchophylla extract and elm bark gum solution respectively;

[0008] Step 2: Mix the tangerine peel after enzyme treatment, mint powder and moxa floss, spray elm bark gum solution, then add salvia miltiorrhiza powder and uncaria rhynchophylla extract, and stir at low speed to obtain a mixture;

[0009] Step 3: Uniformly spread the mixture on cotton paper, compact it, roll it into a strip with a diameter of 10 mm, and let it stand at 40°C for 24 h to obtain the product.

[0010] Further, the tangerine peel in the tangerine peel after enzyme treatment in Step 1 is selected from one of tangerine peel leaves, tangerine peel flowers, and tangerine peel filaments; the preparation method of the tangerine peel after enzyme treatment is to crush the tangerine peel and pass it through an 80-mesh sieve to obtain tangerine peel powder, transfer it to a container, evenly spray an enzyme solution accounting for 9-11% of the mass of the tangerine peel powder, and at the same time cover the container with plastic wrap to prevent volatilization. After standing for 20-30 min, perform segmented drying to obtain the tangerine peel after enzyme treatment.

[0011] Further, the enzyme solution is prepared by adding cellulase and β-glucanase to warm water at 40°C and then adjusting the pH to 4.9-5.1 with 0.1-0.3 mol / L citric acid. The dosage of cellulase accounts for 0.2-0.4 wt% of the total mass of the enzyme solution, and the dosage of β-glucanase accounts for 0.08-0.12 wt% of the total mass of the enzyme solution.

[0012] Further, the segmented drying means drying at 43-47°C and a relative humidity of 54-56% for 1.2-1.8 h, then drying at 53-57°C and a relative humidity of 24-26% for 1.8-2.2 h, and finally drying at 59-61°C and a relative humidity of 7.5-8.5% for 0.45-0.55 h.

[0013] Further, the mint powder and salvia powder in Step 1 are obtained by crushing mint and salvia and passing them through an 80-mesh sieve.

[0014] Further, the extraction method of the uncaria rhynchophylla extract in Step 1 is to crush the uncaria rhynchophylla and pass it through an 80-mesh sieve, then mix it with a 65-75 wt% ethanol solution at a ratio of 1:8-10 g / mL, and perform reflux extraction at 81-85°C for 2-3 h to obtain an uncaria rhynchophylla extract solution. After cooling, filter it through a 300-mesh filter cloth to obtain an uncaria rhynchophylla filtrate, and dry it to constant weight at 80°C under vacuum, that is, obtain it.

[0015] Further, the preparation method of the elm bark gum solution in Step 1 is to cut the elm bark into small pieces, mix it with deionized water at a ratio of 1:9-11 g / mL, boil it over low heat and extract for 1-2 h to obtain an elm bark extract solution. After cooling, filter it through a 300-mesh filter cloth to obtain an elm bark filtrate, and concentrate it by rotary evaporation at 80°C to 1 / 5 of the volume of the elm bark filtrate, that is, obtain it.

[0016] Further, the mass ratio of the tangerine peel after enzyme treatment, mint powder, moxa floss, elm bark gum solution, salvia powder, and uncaria rhynchophylla extract in Step 2 is 1.7-2.1:1.2-1.6:4.8-5.4:1.5-2.5:6.5-7.5:4-5.

[0017] Further, the rotation speed and time of the low-speed stirring in Step 2 are 20-30 rpm and 30-40 min respectively.

[0018] Advantages of the present invention:

[0019] (1) The active substances such as flavonoids and polyphenols contained in the tangerine peel in the present invention can improve vascular endothelial function, relieve hypertension symptoms by dilating blood vessels and improving blood circulation. In the present invention, cellulase and β-glucanase are sprayed on the tangerine peel for enzymatic hydrolysis treatment. With the help of cellulase and β-glucanase, the decomposition of cell walls is promoted, which helps to improve the release of active ingredients during subsequent moxibustion. During the treatment, film covering is carried out to prevent the volatilization of active ingredients and reduce the evaporation of moisture, and then segmented drying is carried out to gradually remove moisture, avoiding the destruction of active ingredients by high temperature, thereby improving the storage stability of the material.

[0020] (2) The menthol component in the mint in the present invention has the effects of effectively soothing blood vessels and relieving tension, helping to refresh the mind and soothe the nerves and reduce blood pressure; the active ingredients such as tanshinone and salvianolic acid in salvia miltiorrhiza help to improve microcirculation and reduce blood pressure; the alkaloids and flavonoids in the extract of uncaria rhynchophylla have obvious sedative and anticonvulsant effects, and can dilate blood vessels and promote blood circulation to relieve hypertension symptoms; the active ingredients in the elm bark gum solution not only have a certain blood pressure lowering effect, but also have viscosity after cooling, which can effectively bond various raw materials together.

[0021] (3) The present invention prepares a composite moxa stick by compounding a variety of raw materials. When in use, the volatile components in the drug components will volatilize, and the non-volatile components can be released from the moxa stick as the moxa stick burns, enter the skin with the heat and then be absorbed transdermally, having a good therapeutic effect on hypertension caused by various reasons. Specific embodiments

[0022] To further elaborate on the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following combines examples to describe in detail the specific embodiments, structures, features and their effects according to the present invention.

[0023] The cellulase and β-glucanase in all examples and comparative examples of the present invention are directly purchased from the market, and are all purchased from Jiangsu Caiwei Biotechnology Co., Ltd.; citric acid is directly purchased from the market, and is all purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.

[0024] Example 1

[0025] A composite moxa stick containing tangerine peel. The preparation method of the composite moxa stick containing tangerine peel in this example comprises the following steps:

[0026] Step 1: Prepare enzymatically treated tangerine peel, mint powder, salvia miltiorrhiza powder, extract of uncaria rhynchophylla and elm bark gum solution respectively;

[0027] Step 2: Mix the enzyme-treated tangerine peel, mint powder, and moxa floss, then spray the elm bark gum solution, and add the salvia miltiorrhiza powder and uncaria rhynchophylla extract, and stir at low speed to obtain a mixture.

[0028] Step 3: Spread the mixture evenly on cotton paper, compact it, roll it into a strip with a diameter of 10 mm, and leave it standing at 40 °C for 24 h to obtain the product.

[0029] In this example, the tangerine peel in the enzyme-treated tangerine peel in Step 1 is tangerine leaf; the preparation method of the enzyme-treated tangerine peel is to crush the tangerine leaf and pass it through an 80-mesh sieve to obtain tangerine leaf powder, transfer it to a container, evenly spray an enzyme solution accounting for 9% of the mass of the tangerine leaf powder, and at the same time cover the container with a plastic wrap to prevent volatilization, and after standing for 20 min, carry out segmented drying to obtain the enzyme-treated tangerine peel.

[0030] The enzyme solution in this example is prepared by adding cellulase and β-glucanase to warm water at 40 °C and adjusting the pH to 4.9 with 0.1 mol / L citric acid. The dosage of cellulase accounts for 0.2 wt% of the total mass of the enzyme solution, and the dosage of β-glucanase accounts for 0.08 wt% of the total mass of the enzyme solution.

[0031] The segmented drying in this example means drying at 43 °C and 54% relative humidity for 1.2 h first, then drying at 53 °C and 24% relative humidity for 1.8 h, and finally drying at 59 °C and 7.5% relative humidity for 0.45 h.

[0032] The mint powder and salvia miltiorrhiza powder in Step 1 of this example are obtained by crushing mint and salvia miltiorrhiza and passing them through an 80-mesh sieve.

[0033] The extraction method of the uncaria rhynchophylla extract in Step 1 of this example is to crush uncaria rhynchophylla and pass it through an 80-mesh sieve, then mix it with a 65 wt% ethanol solution in a ratio of 1:8 g / mL, and carry out reflux extraction at 81 °C for 2 h to obtain an uncaria rhynchophylla extract solution. After cooling, filter it through a 300-mesh filter cloth to obtain an uncaria rhynchophylla filtrate, and dry it to constant weight at 80 °C under vacuum to obtain the uncaria rhynchophylla extract.

[0034] The preparation method of the elm bark gum solution in Step 1 of this example is to cut the elm bark into small pieces, mix it with deionized water in a ratio of 1:9 g / mL, boil it over low heat for 1 h to obtain an elm bark extract solution, cool it, filter it through a 300-mesh filter cloth to obtain an elm bark filtrate, and concentrate it by rotary evaporation at 80 °C to 1 / 5 of the volume of the elm bark filtrate to obtain the elm bark gum solution.

[0035] In this example, the mass ratio of the enzyme-treated tangerine peel, mint powder, moxa floss, elm bark gum solution, salvia miltiorrhiza powder, and uncaria rhynchophylla extract in Step 2 is 1.7:1.2:4.8:1.5:6.5:4.

[0036] In step two of this embodiment, the rotation speed and time of the low-speed stirring are 20 rpm and 30 min respectively.

[0037] Example 2

[0038] A compound moxa stick containing tangerine peel. The preparation method of the compound moxa stick containing tangerine peel in this embodiment comprises the following steps:

[0039] Step one: Prepare tangerine peel after enzyme treatment, mint powder, salvia miltiorrhiza powder, uncaria rhynchophylla extract and elm bark gum solution respectively;

[0040] Step two: Mix the tangerine peel after enzyme treatment, mint powder and moxa floss, spray elm bark gum solution, then add salvia miltiorrhiza powder and uncaria rhynchophylla extract, and stir at low speed to obtain a mixture;

[0041] Step three: Spread the mixture evenly on cotton paper, compact it, roll it into a strip with a diameter of 10 mm, and let it stand at 40 °C for 24 h to obtain the product.

[0042] In this embodiment, the tangerine peel in the tangerine peel after enzyme treatment is tangerine flower; the preparation method of the tangerine peel after enzyme treatment is to crush the tangerine flower, sieve it through an 80-mesh sieve to obtain tangerine flower powder, transfer it to a container, evenly spray enzyme solution accounting for 11% of the mass of the tangerine flower powder, and at the same time cover the container with a plastic wrap to prevent volatilization. After standing for 30 min, carry out segmented drying to obtain the tangerine peel after enzyme treatment.

[0043] The enzyme solution in this embodiment is prepared by adding cellulase and β-glucanase to warm water at 40 °C and adjusting the pH to 5.1 with 0.3 mol / L citric acid. Among them, the dosage of cellulase accounts for 0.4 wt% of the total mass of the enzyme solution, and the dosage of β-glucanase accounts for 0.12 wt% of the total mass of the enzyme solution.

[0044] The segmented drying in this embodiment means drying at 47 °C and 56% relative humidity for 1.8 h first, then drying at 57 °C and 26% relative humidity for 2.2 h, and finally drying at 61 °C and 8.5% relative humidity for 0.55 h.

[0045] In this embodiment, the mint powder and salvia miltiorrhiza powder in step one are obtained by crushing mint and salvia miltiorrhiza and sieving them through an 80-mesh sieve.

[0046] The extraction method of the uncaria rhynchophylla extract in step one of this embodiment is to crush uncaria rhynchophylla and sieve it through an 80-mesh sieve, then mix it with 75 wt% ethanol solution according to the ratio of 1:10 g / mL, carry out reflux extraction at 85 °C for 3 h to obtain uncaria rhynchophylla extract solution, cool it and filter it through a 300-mesh filter cloth to obtain uncaria rhynchophylla filtrate, and dry it to constant weight at 80 °C under vacuum to obtain the product.

[0047] In the first step of this embodiment, the preparation method of the elm bark gum solution is to cut the elm bark into small pieces, mix it with deionized water at a ratio of 1:11 g / mL, boil it over low heat for 2 hours to obtain an elm bark extract, cool it, filter it through a 300-mesh filter cloth to obtain an elm bark filtrate, and rotary evaporate and concentrate it to 1 / 5 of the volume of the elm bark filtrate at 80 °C to obtain it.

[0048] In the second step of this embodiment, the mass ratio of tangerine peel, peppermint powder, moxa floss, elm bark gum solution, salvia miltiorrhiza powder, and uncaria rhynchophylla extract after enzyme treatment is 2.1:1.6:5.4:2.5:7.5:5.

[0049] In the second step of this embodiment, the rotation speed and time of low-speed stirring are 30 rpm and 40 min respectively.

[0050] Example 3

[0051] A compound moxa stick containing tangerine peel. The preparation method of the compound moxa stick containing tangerine peel in this embodiment comprises the following steps:

[0052] Step 1: Prepare tangerine peel, peppermint powder, salvia miltiorrhiza powder, uncaria rhynchophylla extract, and elm bark gum solution after enzyme treatment respectively;

[0053] Step 2: Mix the tangerine peel, peppermint powder, and moxa floss after enzyme treatment, spray the elm bark gum solution, then add the salvia miltiorrhiza powder and uncaria rhynchophylla extract, and stir at low speed to obtain a mixture;

[0054] Step 3: Uniformly spread the mixture on cotton paper, compact it, roll it into a strip with a diameter of 10 mm, and let it stand at 40 °C for 24 hours to obtain it.

[0055] In this embodiment, the tangerine peel in the tangerine peel after enzyme treatment is tangerine peel shreds; the preparation method of the tangerine peel after enzyme treatment is to crush the tangerine peel shreds, sieve them through an 80-mesh sieve to obtain tangerine peel shred powder, transfer it to a container, uniformly spray an enzyme solution accounting for 10% of the mass of the tangerine peel shred powder, and at the same time cover the container with a plastic wrap to prevent volatilization, let it stand for 25 minutes and then carry out segmented drying to obtain the tangerine peel after enzyme treatment.

[0056] The enzyme solution in this embodiment is prepared by adding cellulase and β-glucanase to warm water at 40 °C and adjusting the pH to 5 with 0.2 mol / L citric acid. Among them, the dosage of cellulase accounts for 0.2-0.4 wt% of the total mass of the enzyme solution, and the dosage of β-glucanase accounts for 0.1 wt% of the total mass of the enzyme solution.

[0057] The segmented drying in this embodiment means drying at 45 °C and 55% relative humidity for 1.5 hours first, then drying at 55 °C and 25% relative humidity for 2 hours, and finally drying at 60 °C and 8% relative humidity for 0.5 hours.

[0058] In step 1 of this embodiment, the mint powder and salvia miltiorrhiza powder are obtained by crushing mint and salvia miltiorrhiza and passing through an 80-mesh sieve.

[0059] In step 1 of this embodiment, the extraction method of the uncaria rhynchophylla extract is as follows: after crushing uncaria rhynchophylla and passing through an 80-mesh sieve, it is mixed with a 70wt% ethanol solution at a ratio of 1:9 g / mL, and then reflux-extracted at 83 °C for 2.5 h to obtain an uncaria rhynchophylla extract solution. After cooling, it is filtered through a 300-mesh filter cloth to obtain an uncaria rhynchophylla filtrate, and then vacuum-dried at 80 °C to constant weight, thus obtaining it.

[0060] In step 1 of this embodiment, the preparation method of the elm bark gum solution is as follows: cut the elm bark into small pieces, mix it with deionized water at a ratio of 1:10 g / mL, boil it over low heat and extract for 1.5 h to obtain an elm bark extract solution. After cooling, it is filtered through a 300-mesh filter cloth to obtain an elm bark filtrate, and then rotary-evaporated and concentrated at 80 °C to 1 / 5 of the volume of the elm bark filtrate, thus obtaining it.

[0061] In step 2 of this embodiment, the mass ratio of tangerine peel, mint powder, mugwort floss, elm bark gum solution, salvia miltiorrhiza powder, and uncaria rhynchophylla extract after enzyme treatment is 1.9:1.4:5.1:2:7:4.5.

[0062] In step 2 of this embodiment, the rotation speed and time of low-speed stirring are 25 rpm and 35 min, respectively.

[0063] Comparative Example 1

[0064] On the basis of Example 3, the tangerine peel is not subjected to enzyme treatment, directly crushed and passed through an 80-mesh sieve, and other conditions are the same as those in Example 3.

[0065] Comparative Example 2

[0066] On the basis of Example 3, the cellulase in the enzyme solution is removed and replaced with an equal weight of β-glucanase, and other conditions are the same as those in Example 3.

[0067] Comparative Example 3

[0068] On the basis of Example 3, the β-glucanase in the enzyme solution is removed and replaced with an equal weight of cellulase, and other conditions are the same as those in Example 3.

[0069] Comparative Example 4

[0070] On the basis of Example 3, the treatment of covering with plastic wrap during the enzyme treatment of tangerine peel is removed, and other conditions are the same as those in Example 3.

[0071] Comparative Example 5

[0072] On the basis of Example 3, while keeping other conditions the same, the segmented drying operation during the enzyme treatment of tangerine peel is changed to drying at 45 °C and 55% relative humidity for 4 h.

[0073] Comparative Example 6

[0074] On the basis of Example 3, while keeping other conditions the same, the segmented drying operation in the tangerine red enzyme treatment process was changed to drying for 4 h under the conditions of 60 °C and 8% relative humidity.

[0075] Comparative Example 7

[0076] On the basis of Example 3, the tangerine red after enzyme treatment was removed and replaced with mint powder of equal weight, and other conditions were the same as those in Example 3.

[0077] Comparative Example 8

[0078] On the basis of Example 3, the mint powder was removed and replaced with salvia miltiorrhiza powder of equal weight, and other conditions were the same as those in Example 3.

[0079] Comparative Example 9

[0080] On the basis of Example 3, the salvia miltiorrhiza powder was removed and replaced with uncaria rhynchophylla extract of equal weight, and other conditions were the same as those in Example 3.

[0081] Comparative Example 10

[0082] On the basis of Example 3, the uncaria rhynchophylla extract was removed and replaced with tangerine red after enzyme treatment of equal weight, and other conditions were the same as those in Example 3.

[0083] Comparative Example 11

[0084] On the basis of Example 3, the elm bark gum solution was removed and replaced with paste. The paste was obtained by mixing flour and water in a ratio of 1:2 and boiling until it became viscous and had large bubbles, and other conditions were the same as those in Example 3.

[0085] Comparative Example 12

[0086] On the basis of Example 3, the low-speed stirring in Step 2 was changed to stirring at a speed of 100 rpm for 35 min.

[0087] Forty-eight patients with hypertension were selected. The diagnostic criteria for hypertension were that the systolic blood pressure was ≧140 mmHg and / or the diastolic blood pressure was ≧90 mmHg measured three times on non-consecutive days without taking antihypertensive drugs. The subjects were of both genders, aged between 18 and 80 years. The selected patients needed to exclude those with a history of hypertension, pregnant and lactating women, those with severe lesions in other organ systems such as the liver, kidney, lung, brain, and endocrine system, those allergic to the sample raw materials, those who could not accept the cooperation in the investigation, and those who expressed their willingness to participate in the trial and signed a written informed consent form before the trial;

[0088] Test products: The patients were randomly divided into 16 groups. One group was the control group without moxibustion, and the remaining 15 groups were the experimental groups. Moxibustion treatment was carried out respectively with the compound moxa sticks prepared in Examples 1-3 and Comparative Examples 1-12 of the present invention as samples.

[0089] The test method was as follows: Moxibustion treatment was performed on the Baihui acupoint, Shenque acupoint, and Yongquan acupoint. It was appropriate to moxibust at a distance of 2-3 cm from the skin of the acupoint, so that the local area of the patient's acupoint had a warm feeling without burning pain. Each acupoint was moxibusted for 15 minutes. The blood pressure (supine position, right upper limb) was measured before and after each treatment. It was carried out 2 times a week for two consecutive months.

[0090] Taking the systolic blood pressure and diastolic blood pressure measured after two months of moxibustion as the evaluation criteria, the results of each group of samples were averaged and recorded as shown in Table 1 below.

[0091] Table 1 Results of moxibustion treatment

[0092] Systolic blood pressure / mmHg Diastolic blood pressure / mmHg Control group 141.89 87.35 Example 1 129.75 76.61 Example 2 129.83 76.69 Example 3 129.65 76.54 Comparative example 1 135.53 81.23 Comparative example 2 135.17 79.48 Comparative example 3 135.84 79.65 Comparative example 4 132.08 78.12 Comparative example 5 131.87 78.28 Comparative example 6 137.45 82.75 Comparative example 7 136.58 82.02 Comparative example 8 135.33 80.56 Comparative example 9 134.86 80.29 Comparative example 10 134.25 79.87 Comparative example 11 131.08 77.66 Comparative example 12 131.29 77.98

[0093] As can be seen from Table 1, the compound moxa sticks containing orange peel prepared in Examples 1-3 of the present invention have a good therapeutic effect on hypertension.

[0094] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments by using the above-disclosed technical content within the scope of the technical solution of the present invention. However, as long as it does not depart from the content of the technical solution of the present invention, any indirect modification, equivalent change, and modification made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A compound moxa stick containing tangerine peel, characterized in that: The preparation method of the compound moxa stick containing tangerine peel comprises the following steps: Step 1: Prepare tangerine peel after enzyme treatment, mint powder, salvia miltiorrhiza powder, uncaria rhynchophylla extract and elm bark gum solution respectively; Step 2: Mix the tangerine peel after enzyme treatment, mint powder and moxa floss, spray the elm bark gum solution, then add salvia miltiorrhiza powder and uncaria rhynchophylla extract, and stir at a low speed to obtain a mixture; Step 3: Uniformly spread the mixture on cotton paper, compact it, roll it into a strip with a diameter of 10 mm, and let it stand at 40 °C for 24 h to obtain the product.

2. The compound moxa stick containing tangerine peel according to claim 1, wherein The tangerine peel in the tangerine peel after enzyme treatment described in Step 1 is selected from one of tangerine peel leaves, tangerine peel flowers and tangerine peel shreds; the preparation method of the tangerine peel after enzyme treatment is to crush the tangerine peel, sieve it through an 80-mesh sieve to obtain tangerine peel powder, transfer it to a container, uniformly spray an enzyme solution accounting for 9-11% of the mass of the tangerine peel powder, cover the container with a plastic wrap to prevent volatilization at the same time, let it stand for 20-30 min and then carry out segmented drying to obtain the tangerine peel after enzyme treatment.

3. The compound moxa stick containing orange peel according to claim 2, wherein: The enzyme solution is prepared by adding cellulase and β-glucanase to warm water at 40 °C and adjusting the pH to 4.9-5.1 with 0.1-0.3 mol / L citric acid, wherein the dosage of cellulase accounts for 0.2-0.4 wt% of the total mass of the enzyme solution, and the dosage of β-glucanase accounts for 0.08-0.12 wt% of the total mass of the enzyme solution.

4. A compound moxa stick containing tangerine peel according to claim 2, characterized in that: The segmented drying means drying at 43-47 °C and 54-56% relative humidity for 1.2-1.8 h first, then drying at 53-57 °C and 24-26% relative humidity for 1.8-2.2 h, and finally drying at 59-61 °C and 7.5-8.5% relative humidity for 0.45-0.55 h.

5. The compound moxa stick containing orange peel according to claim 1, characterized in that: The extraction method of the uncaria rhynchophylla extract described in Step 1 is to crush uncaria rhynchophylla, sieve it through an 80-mesh sieve, mix it with a 65-75 wt% ethanol solution at a ratio of 1:8-10 g / mL, carry out reflux extraction at 81-85 °C for 2-3 h to obtain an uncaria rhynchophylla extract solution, cool it and filter it through a 300-mesh filter cloth to obtain an uncaria rhynchophylla filtrate, and dry it to constant weight at 80 °C under vacuum to obtain the product.

6. The compound moxa stick containing tangerine peel according to claim 1, characterized in that: The preparation method of the elm bark gum solution described in Step 1 is to cut the elm bark into small pieces, mix it with deionized water at a ratio of 1:9-11 g / mL, boil it over low heat and extract for 1-2 h to obtain an elm bark extract solution, cool it and filter it through a 300-mesh filter cloth to obtain an elm bark filtrate, and concentrate it by rotary evaporation at 80 °C to 1 / 5 of the volume of the elm bark filtrate to obtain the product.

7. A compound moxa stick containing tangerine peel according to claim 1, characterized in that: The mass ratio of the tangerine peel after enzyme treatment, mint powder, moxa floss, elm bark gum solution, salvia miltiorrhiza powder and uncaria rhynchophylla extract described in Step 2 is 1.7-2.1:1.2-1.6:4.8-5.4:1.5-2.5:6.5-7.5:4-5.

8. A composite moxa stick containing tangerine peel according to claim 1, characterized in that: The rotation speed and time of the low-speed stirring described in Step 2 are 20-30 rpm and 30-40 min respectively.