Compound liver-tonifying oral liquid and preparation method thereof

Abstract

The preparation method of the compound liver-tonifying oral liquid comprises the following steps: S1, extracting a sedum sarmentosum concentrated solution; s2, extracting a silymarin concentrated solution; s3, extracting a fructus schizandrae concentrated solution; s4, mixing the ingredients; and S5, filtering. Compared with tablets, the compound Yiganling oral liquid disclosed by the invention is better in absorption and quick in drug effect development, and solves the problem that some patients are difficult to swallow.

Description

Technical Field

[0001] The present invention belongs to the field of pharmaceuticals, and particularly relates to a compound Yiganling oral liquid and a preparation method thereof. Background Art

[0002] As a traditional Chinese medicine formula, Yiganling is mainly composed of ingredients such as silymarin, and is a natural medicine extracted and refined from the fruits of the Compositae plant Silybum marianum. It can stabilize the liver cell membrane, prevent toxins from penetrating and damaging the liver, and can also accelerate the synthesis of DNA in liver cells, promote the repair and regeneration of damaged liver cells, thereby playing a role in improving liver function and protecting the liver, and is widely used in the treatment of liver diseases such as chronic hepatitis and cirrhosis.

[0003] However, at present, the dosage forms of Yiganling preparations for hepatitis diseases on the market are mainly tablets or granules. For the middle-aged and elderly groups with relatively weak gastrointestinal functions or poor absorption functions, there are many problems with these dosage forms. Tablets and granules need to disintegrate in the gastrointestinal tract before the drug components can be released and absorbed by the human body. However, in middle-aged and elderly people, the gastrointestinal peristalsis slows down and the secretion of digestive juices decreases, resulting in an extended drug disintegration process, slow release of active ingredients, and thus a significant reduction in drug absorption rate, affecting the treatment effect. At the same time, tablets are characterized by a relatively large volume and hard texture. For middle-aged and elderly patients with degenerated swallowing functions, it is easy to have difficulty swallowing, and may even cause dangerous situations such as choking. This not only reduces the compliance of patients taking medicine, but also brings inconvenience and risks to the treatment process. Therefore, there is an urgent need to develop a new dosage form of Yiganling that is more suitable for the middle-aged and elderly groups and can improve the drug absorption efficiency and taking convenience. Summary of the Invention

[0004] The purpose of the present invention is to provide a compound Yiganling oral liquid and a preparation method thereof to solve the technical problem of difficult swallowing for some patients.

[0005] To achieve the above purpose, the specific technical solutions of a compound Yiganling oral liquid and a preparation method thereof of the present invention are as follows:

[0006] A preparation method of a compound Yiganling oral liquid includes the following steps:

[0007] S1. Extract the concentrated Sedum sarmentosum liquid: Wash and chop Sedum sarmentosum, soak it with an extraction solvent, and obtain the Sedum sarmentosum extract by the reflux method. Concentrate the Sedum sarmentosum extract by the method of reduced pressure distillation to obtain the concentrated Sedum sarmentosum liquid;

[0008] S2. Extract the concentrated silymarin liquid: Grind the fruits of Silybum marianum into powder, obtain the silymarin extract by impregnating the silymarin powder with an extraction solvent and then filtering, and concentrate the silymarin extract by the method of reduced pressure distillation to obtain the concentrated silymarin liquid;

[0009] S3. Extract Schisandra chinensis concentrated liquid: Wash and dry the Schisandra chinensis fruits, then crush them to obtain Schisandra chinensis coarse powder. Soak the Schisandra chinensis coarse powder with an extraction solvent and obtain Schisandra chinensis extract by reflux method. Concentrate the Schisandra chinensis extract by vacuum distillation to obtain Schisandra chinensis concentrated liquid;

[0010] S4. Ingredient mixing: Add flavoring agent solution, Sedum sarmentosum Bunge concentrated liquid, silymarin concentrated liquid, Schisandra chinensis concentrated liquid, and purified water to the ingredient tank in sequence, and stir and mix;

[0011] S5. Filtration: Filter the mixed solution obtained in S4 to obtain Compound Yiganling Oral Liquid.

[0012] As a further improvement of the present invention, the extraction of Sedum sarmentosum Bunge concentrated liquid in S1 includes the following steps:

[0013] S1.1. Wash and cut Sedum sarmentosum Bunge;

[0014] S1.2. Use an ethanol solution with a volume fraction of 60% - 70% as the extraction solvent. Mix the cut Sedum sarmentosum Bunge with the ethanol solution at a mass - to - volume ratio of 1:(8 - 10) g / mL in an extraction tank equipped with a stirring device, and soak it while stirring at a speed of 60 - 80 r / min for 2 hours;

[0015] S1.3. Use the method of heating and reflux extraction to extract the Sedum sarmentosum Bunge extract in the extraction tank 2 - 3 times. The extraction temperature is 50°C - 60°C, and the extraction time for each time is 1.5 - 2.5 hours;

[0016] S1.4. Combine the Sedum sarmentosum Bunge extracts obtained from multiple extractions into a concentration tank equipped with a stirring device. Heat the concentration tank by vacuum distillation. The vacuum degree in the concentration tank is maintained at - 0.08 - - 0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 - 50 r / min. Stop concentrating when the relative density of the extract reaches 1.10 - 1.20 to obtain Sedum sarmentosum Bunge concentrated liquid.

[0017] As a further improvement of the present invention, the extraction of silymarin concentrated liquid in S2 includes the following steps:

[0018] S2.1. Grind the silybum marianum fruits into powder, and obtain silybum marianum powder by passing through a 40 - 60 mesh sieve;

[0019] S2.2. Use an ethanol solution with a volume fraction of 60% - 70% as the extraction solvent. Mix the silybum marianum powder with the ethanol solution at a mass - to - volume ratio of 1:(8 - 10) g / mL, impregnate for 7 days, and stir once every 12 hours;

[0020] S2.3. After the impregnation is completed, filter the silymarin extract and pour it into a concentration tank equipped with a stirring device. Heat the concentration tank by means of vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 to -0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 to 50 r / min. Stop the concentration when the relative density of the extract is concentrated to 1.10 to 1.20 to obtain the concentrated silymarin solution.

[0021] As a further improvement of the present invention, the extraction of the Schisandra chinensis concentrated solution in S3 includes the following steps:

[0022] S3.1. After cleaning and drying the Schisandra chinensis fruits, crush them into coarse Schisandra chinensis powder;

[0023] S3.2. Use an ethanol solution with a volume fraction of 60% to 70% as the extraction solvent. Mix the coarse Schisandra chinensis powder and the ethanol solution at a mass-volume ratio of 1:(8 to 12) g / mL and soak them in an extraction tank equipped with a stirring device, and stir at a speed of 60 to 80 r / min for 2 hours;

[0024] S3.3. Use the method of heating and reflux extraction to extract the Schisandra chinensis extract in the extraction tank 2 to 3 times. The extraction temperature is 50 to 60 °C, and the extraction time for each time is 1 to 2 hours;

[0025] S3.4. Combine and filter the Schisandra chinensis extracts obtained from multiple extractions and place them in a concentration tank equipped with a stirring device. Heat the concentration tank by means of vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 to -0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 to 50 r / min. Stop the concentration when the relative density of the extract is concentrated to 1.10 to 1.20 to obtain the concentrated Schisandra chinensis solution.

[0026] As a further improvement of the present invention, in S4, the volume ratio of the Sedum sarmentosum concentrated solution, the silymarin concentrated solution, the Schisandra chinensis concentrated solution, the flavoring agent solution, and the purified water is (10 to 10.1):(2.9 to 3):(2 to 2.1):1:(200 to 205).

[0027] As a further improvement of the present invention, in S4, the mixed solution is stirred for 30 to 60 minutes under the conditions of a temperature of 30 °C to 35 °C and a stirring speed of 100 to 200 r / min.

[0028] As a further improvement of the present invention, the flavoring agent solution is prepared by mixing one of sucrose, stevioside, and potassium sorbate with purified water.

[0029] As a further improvement of the present invention, in S4, the Sedum sarmentosum concentrated solution is heated to 30 to 35 °C before mixing.

[0030] As a further improvement of the present invention, in S5 filtration, the mixed solution first passes through a filter screen with a pore size of 10 - 50 μm, and then passes through a filter membrane with a pore size of 0.4 - 0.5 μm under a vacuum environment of -0.05 to -0.08 MPa.

[0031] A compound Yiganling oral liquid is prepared according to the above preparation method.

[0032] Beneficial effects:

[0033] The preparation method of the present invention designs exclusive extraction processes for different raw material characteristics for extracting the concentrated extracts of Sedum sarmentosum, silymarin, and Schisandra chinensis. Sedum sarmentosum can fully dissolve its effective components such as flavonoids and terpenoids through washing, chopping, ethanol soaking, and reflux extraction; after the fruits of Silybum marianum are ground and then impregnated and filtered, it helps to efficiently obtain silymarin; the fruits of Schisandra chinensis are dried, pulverized, soaked, and refluxed to fully extract active substances such as lignans. The multi-step extraction process greatly improves the extraction rate of effective components, laying a solid foundation for the oral liquid to exert a good liver protection effect.

[0034] The concentration method of vacuum distillation is adopted for all three extraction solutions, which reduces the required temperature for concentration, effectively avoids the degradation and inactivation of thermosensitive components in Sedum sarmentosum, silymarin, and Schisandra chinensis due to high temperature, ensures the integrity of the chemical structures of each component, and thus maintains the stability and reliability of the efficacy of the oral liquid.

[0035] In the ingredient mixing step, the flavoring agent solution, the three concentrated extracts, and purified water are added to the ingredient tank in a specific order, which helps the components to be more evenly dispersed during the stirring process. Through the reasonable addition order and stirring operation, it avoids the phenomena of local high concentration or uneven mixing caused by chaotic ingredient addition, ensures that the ingredient ratio and content of each batch and each part of the compound Yiganling oral liquid prepared are consistent, and improves the uniformity of the product quality.

[0036] Filtering the mixed solution effectively removes the residual insoluble impurities, tiny particles, and possible microorganisms in the solution. The compound Yiganling oral liquid obtained after filtration has high clarity and few impurities, meets the high-standard quality requirements of oral preparations, reduces the risk of adverse reactions caused by impurities, and ensures the safety and effectiveness of patient medication.

[0037] The compound Yiganling oral liquid breaks through the dosage form limitations of traditional tablets and granules. The liquid dosage form does not need to disintegrate in the gastrointestinal tract, can directly contact the gastrointestinal mucosa, and speeds up the release and absorption rate of the effective components of the drug. It is especially suitable for middle-aged and elderly groups with poor gastrointestinal function and weak absorption ability. At the same time, the oral liquid is easy to swallow, solves the problem of difficult swallowing that may exist in traditional dosage forms, and greatly improves the medication convenience and compliance of patients. Specific embodiments

[0038] In order to better understand the purpose, structure and function of the present invention, a compound Yiganling oral liquid and its preparation method of the present invention will be further described in detail.

[0039] Example of implementation:

[0040] A compound Yiganling oral liquid and its preparation method. First, the concentrated solutions of three components are extracted separately. After the Sedum sarmentosum and Schisandra chinensis are cleaned, they are soaked in an ethanol solution, then reflux-extracted and concentrated by vacuum distillation; after the fruits of Silybum marianum are ground into powder, they are impregnated with an ethanol solution, filtered, and concentrated by vacuum distillation. Then, the concentrated solution of Sedum sarmentosum, the concentrated solution of silymarin, the concentrated solution of Schisandra chinensis, the flavoring agent solution and purified water are stirred and mixed. Finally, the mixed solution passes through a coarse filter screen and a filter membrane in sequence to complete the filtration, and the oral liquid is obtained. The specific implementation method is as follows:

[0041] Select fresh Sedum sarmentosum as the extraction raw material, wash it carefully to remove the attached soil, impurities, etc. on the surface to avoid these substances mixing into the extraction solution and affecting the quality of the subsequent product. After washing, cut the Sedum sarmentosum into pieces, and use an ethanol solution with a volume fraction of 70% as the extraction solvent. Ethanol is a commonly used organic solvent that can effectively dissolve the active ingredients in Sedum sarmentosum with the effects of promoting diuresis and reducing jaundice, and clearing heat and detoxifying, such as water-soluble flavonoids, glycosides, etc. Mix the cut Sedum sarmentosum with this ethanol solution at a mass-volume ratio of 1:8 g / mL, and stir at a speed of 60 r / min for 2 hours to ensure that the Sedum sarmentosum can fully release the active ingredients in sufficient solvent. Place the mixed Sedum sarmentosum and ethanol solution in an environment of 50 °C, and use the reflux extraction method for extraction. Using the principle that the solvent vaporizes when heated and then condenses and returns to the extractor for continuous extraction, the solvent can be continuously recycled, ensuring that the solvent always maintains a high concentration difference during the extraction process, thereby improving the extraction efficiency. During this process, extraction is carried out 3 times, and the extraction time for each time is 2 hours. Multiple extractions can extract as completely as possible the active ingredients in Sedum sarmentosum, and a reasonable extraction duration for each time ensures that the extraction process is sufficient and avoids component damage caused by over-extraction. Combine the extraction solutions obtained from the 3 extractions into a concentration tank, and heat the concentration tank by vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 MPa. Vacuum concentration is to evaporate the solvent under conditions lower than atmospheric pressure, reducing the boiling point of the solution, so that the concentration operation can be carried out at a lower temperature, preventing the thermosensitive active ingredients in Sedum sarmentosum from decomposing or deteriorating at high temperatures. Heat the concentration tank until the extraction solution boils, and at the same time stir the extraction solution at a stirring speed of 30 r / min. Stop concentrating when the extraction solution is concentrated to a relative density of 1.10 to obtain the concentrated solution of Sedum sarmentosum.

[0042] The milk thistle seeds are crushed to pass through a 50-mesh sieve, increasing the contact area between the milk thistle seeds and the extraction solvent, which helps silymarin dissolve more fully from the seeds into the solvent during the subsequent extraction process. An ethanol solution with a volume fraction of 70% is selected as the extraction solvent, and the crushed milk thistle seeds are mixed with it at a mass-volume ratio of 1:8 g / mL. Ethanol is a good organic solvent that can effectively dissolve components such as silymarin, and the addition of water can adjust the polarity of the solvent, making the extraction more selective and also facilitating subsequent operations such as concentration. Impregnation is carried out at room temperature for up to 7 days, with stirring every 12 hours during this period. Long-term impregnation can ensure that silymarin is fully dissolved in the solvent, and stirring is to break the mass transfer resistance at the solid-liquid interface, enabling the solvent to contact the seed particles more fully, accelerating the extraction speed, and making the extraction process more uniform and efficient. After the impregnation is completed, the solid residue is filtered to separate it from the extract. Filtration can remove impurities such as undissolved seed residues, obtaining a relatively pure extract containing silymarin, providing a basis for subsequent concentration and purification operations. The silymarin extract is concentrated under reduced pressure in a similar way to the concentration method of the Sedum sarmentosum Bunge concentrated solution. Reducing the pressure lowers the boiling point of the solution, and the solvent is evaporated at a lower temperature, which can avoid the decomposition or deterioration of silymarin at high temperatures, and finally obtain a concentrated silymarin solution.

[0043] Select Schisandra chinensis fruits that are dry, free from mildew, and have plump fruits, and remove the fruit stalks, impurities, and broken particles. The Schisandra chinensis fruits are crushed into coarse powder and passed through a 30-mesh sieve, with the particle size controlled at 0.5 - 2 mm. An ethanol solution with a volume fraction of 70% is used as the extraction solvent, and the Schisandra chinensis coarse powder is mixed with the ethanol solution at a mass-volume ratio of 1:8 g / mL in an extraction tank and soaked, and stirred at a speed of 60 - 80 r / min for 2 hours. The Schisandra chinensis extract is concentrated under reduced pressure in a similar way to the concentration method of the Sedum sarmentosum Bunge concentrated solution. Reducing the pressure lowers the boiling point of the solution, and the solvent is evaporated at a lower temperature, which can avoid the decomposition or deterioration of Schisandra chinensis at high temperatures, and finally obtain a concentrated Schisandra chinensis solution.

[0044] Taking the preparation of 1000 ml of oral liquid as an example, 200 mL of purified water is added to a batching tank, the stirring at a speed of 50 r / min is started, 50 g of sucrose is slowly added, and continuous stirring is carried out until it is completely dissolved to form a clear solution. 350 mL of the Sedum sarmentosum Bunge concentrated solution and 280 mL of the concentrated silymarin solution are added in sequence, the stirring speed is increased to 100 r / min, and mixing is carried out for 20 minutes to ensure uniform dispersion. The Sedum sarmentosum Bunge concentrated solution is heated to 30 °C before mixing to avoid flocculation caused by low temperature. 120 mL of the concentrated Schisandra chinensis solution is slowly poured in, and stirring is continued for 10 minutes. Purified water is added to the tank until the total volume reaches 1000 mL, and after stirring for 5 minutes, it is left standing for 10 minutes to allow the bubbles to escape.

[0045] First, pass the mixed solution through a filter screen with a pore size of 50 μm to remove large particulate impurities (such as plant fibers and undissolved flavoring agent particles in the Sedum sarmentosum or Schisandra chinensis concentrated solution). Then, place it into a membrane filtration device and pass it through a filtration membrane with a pore size of 0.5 μm under a vacuum environment of -0.05 MPa to remove fine particles (such as colloids and protein aggregates), obtaining Compound Yiganling Oral Liquid. After sterilization filtration, the mixed solution is immediately filled to avoid contamination caused by long-term exposure. If necessary, a sterilizing-grade filter membrane with a pore size of 0.22 μm (such as a polyvinylidene fluoride membrane) can be used for terminal filtration, and the qualified filtrate is filled into a glass oral liquid bottle or a polypropylene plastic bottle meeting the pharmaceutical standard in a clean environment, controlling the filling accuracy to ensure that the volume of each bottle meets the regulations (such as 10 mL / bottle).

[0046] In the preparation method of the present invention, specific extraction processes are respectively adopted for Sedum sarmentosum, silymarin, and Schisandra chinensis. Using an ethanol solution with a volume fraction as the extraction solvent, in combination with an appropriate solid-liquid ratio, stirring speed, and extraction time, the active ingredients in the plants can be fully dissolved. Sedum sarmentosum is extracted multiple times by the reflux method, silymarin is extracted by impregnation followed by filtration, and Schisandra chinensis is also extracted by the reflux method. These methods can significantly improve the extraction rate of the active ingredients, ensuring a good efficacy basis for the oral liquid. The three extraction solutions are concentrated by vacuum distillation, maintaining a vacuum low-pressure state in the concentration tank. Under this condition, the concentration temperature is relatively low, which can effectively avoid the destruction of heat-sensitive components and ensure the stability of the active ingredients in Sedum sarmentosum, silymarin, and Schisandra chinensis. The concentrated solution of Sedum sarmentosum, the concentrated solution of silymarin, the concentrated solution of Schisandra chinensis, the flavoring agent solution, and purified water are mixed, enabling the hepatoprotective effects of the three plant components to synergistically act together on the treatment and prevention of liver diseases. At the same time, a reasonable addition amount of the flavoring agent can effectively improve the taste of the oral liquid and enhance the compliance of patients taking the medicine. During the mixing process, controlling the temperature, stirring speed, and continuously stirring can ensure that all components are fully and evenly mixed, avoiding precipitation or stratification. The multi-stage filtration process, first passing through a filter screen for rough filtration and then passing through a filtration membrane under a vacuum environment, can effectively remove impurities, microorganisms, and fine particles in the solution, ensuring that the finished oral liquid has high clarity, reliable quality and safety, meeting the standards of oral pharmaceutical water and the requirements of drug quality.

[0047] The Compound Yiganling Oral Liquid prepared by the preparation method of the present invention is in a liquid dosage form. Compared with traditional tablets and granules, it is easier to swallow, especially suitable for middle-aged and elderly groups with poor gastrointestinal function, poor absorption function, and difficulty in swallowing. Moreover, the oral liquid directly enters the gastrointestinal tract without a disintegration process, and the active ingredients of the drug can be released and absorbed by the human body faster, improving the bioavailability of the drug and enabling the hepatoprotective treatment effect to be exerted faster.

[0048] It will be understood that the present invention is described by way of some embodiments, and those skilled in the art will be aware that various changes or equivalent substitutions can be made to these features and embodiments without departing from the spirit and scope of the present invention. Additionally, under the teaching of the present invention, these features and embodiments can be modified to adapt to specific circumstances and materials without departing from the spirit and scope of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application belong to the scope protected by the present invention.

Claims

1. A preparation method of compound Yiganling oral liquid, characterized in that, It includes the following steps: S1. Extract the concentrated Sedum sarmentosum juice: Wash and chop Sedum sarmentosum, soak it with an extraction solvent, and obtain the Sedum sarmentosum extract by the reflux method. Concentrate the Sedum sarmentosum extract by vacuum distillation to obtain the concentrated Sedum sarmentosum juice; S2. Extract the concentrated silymarin juice: Grind the silybum marianum fruits into powder, and obtain the silymarin extract by impregnating the silybum marianum powder with an extraction solvent and then filtering. Concentrate the silymarin extract by vacuum distillation to obtain the concentrated silymarin juice; S3. Extract the concentrated Schisandra chinensis juice: Wash and dry the Schisandra chinensis fruits and then crush them to obtain the crude Schisandra chinensis powder. Soak the crude Schisandra chinensis powder with an extraction solvent and obtain the Schisandra chinensis extract by the reflux method. Concentrate the Schisandra chinensis extract by vacuum distillation to obtain the concentrated Schisandra chinensis juice; S4. Ingredient mixing: Add the flavoring agent solution, concentrated Sedum sarmentosum juice, concentrated silymarin juice, concentrated Schisandra chinensis juice, and purified water to the ingredient tank in sequence, and stir and mix; S5. Filtration: Filter the mixed solution obtained in S4 to obtain the compound Yiganling oral liquid.

2. The preparation method of the compound Yiganling oral liquid according to claim 1, characterized in that, The extraction of the concentrated Sedum sarmentosum juice in S1 includes the following steps: S1.

1. Wash and chop Sedum sarmentosum; S1.

2. Use an ethanol solution with a volume fraction of 60% - 70% as the extraction solvent. Mix the chopped Sedum sarmentosum with the ethanol solution at a mass-to-volume ratio of 1:(8 - 10) g / mL in an extraction tank equipped with a stirring device, and stir at a speed of 60 - 80 r / min for 2 hours; S1.

3. Use the heating reflux extraction method to extract the Sedum sarmentosum extract in the extraction tank 2 - 3 times. The extraction temperature is 50°C - 60°C, and the extraction time for each time is 1.5 - 2.5 hours; S1.

4. Combine the Sedum sarmentosum extracts obtained from multiple extractions into a concentration tank equipped with a stirring device. Heat the concentration tank by vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 - -0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 - 50 r / min. Stop concentrating when the relative density of the extract reaches 1.10 - 1.20 to obtain the concentrated Sedum sarmentosum juice.

3. The preparation method of the compound Yiganling oral liquid according to claim 1, characterized in that, The extraction of the concentrated silymarin juice in S2 includes the following steps: S2.

1. Grind the silybum marianum fruits into powder, and obtain the silybum marianum powder by passing through a 40 - 60 mesh sieve; S2.

2. Use an ethanol solution with a volume fraction of 60% - 70% as the extraction solvent. Mix the silybum marianum powder with the ethanol solution at a mass-to-volume ratio of 1:(8 - 10) g / mL, impregnate for 7 days, and stir once every 12 hours; S2.

3. After impregnation, filter the silymarin extract and pour it into a concentration tank equipped with a stirring device. Heat the concentration tank by vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 - -0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 - 50 r / min. Stop concentrating when the relative density of the extract reaches 1.10 - 1.20 to obtain the concentrated silymarin juice.

4. The preparation method of the compound Yiganling oral liquid according to claim 1, wherein, The extraction of the concentrated Schisandra chinensis juice in S3 includes the following steps: S3.

1. Clean and dry the Schisandra chinensis fruits, and then crush them into coarse Schisandra chinensis powder. S3.

2. Use an ethanol solution with a volume fraction of 60% - 70% as the extraction solvent. Mix the coarse Schisandra chinensis powder and the ethanol solution at a mass-to-volume ratio of 1:(8 - 12) g / mL in an extraction tank equipped with a stirring device, soak them, and stir at a speed of 60 - 80 r / min for 2 hours. S3.

3. Use the method of heating under reflux extraction to extract the Schisandra chinensis extract in the extraction tank 2 - 3 times. The extraction temperature is 50 - 60 °C, and the extraction time for each time is 1 - 2 hours. S3.

4. Combine and filter the Schisandra chinensis extracts obtained from multiple extractions, and place them in a concentration tank equipped with a stirring device. Heat the concentration tank by means of vacuum distillation. The vacuum degree in the concentration tank is maintained at -0.08 - -0.09 MPa. Heat the concentration tank until the extract boils, and at the same time stir the extract at a stirring speed of 30 - 50 r / min. Stop concentrating when the extract is concentrated to a relative density of 1.10 - 1.20 to obtain the Schisandra chinensis concentrated solution.

5. The preparation method of the compound Yiganling oral liquid according to claim 1, characterized in that, In S4, the volume ratio of the Sedum sarmentosum concentrated solution, silybin concentrated solution, Schisandra chinensis concentrated solution, flavoring agent solution, and purified water is (10 - 10.1):(2.9 - 3):(2 - 2.1):1:(200 - 205).

6. The preparation method of the compound Yiganling oral liquid according to claim 5, characterized in that, In S4, the mixed solution is stirred for 30 - 60 minutes under the conditions of a temperature of 30 °C - 35 °C and a stirring speed of 100 - 200 r / min.

7. The preparation method of the compound Yiganling oral liquid according to claim 1, characterized in that, The flavoring agent solution is prepared by mixing one of sucrose, stevioside, and potassium sorbate with purified water.

8. The preparation method of the compound Yiganling oral liquid according to claim 6, characterized in that, In S4, the Sedum sarmentosum concentrated solution is heated to 30 - 35 °C before mixing.

9. The preparation method of the compound Yiganling oral liquid according to claim 1, wherein, In S5 filtration, first pass the mixed solution through a filter screen with a pore size of 10 - 50 μm, and then pass it through a filter membrane with a pore size of 0.4 - 0.5 μm under a vacuum environment of -0.05 - -0.08 MPa.

10. A compound Yiganling oral liquid, characterized in that, Prepared by the preparation method of the compound Yiganling oral liquid according to any one of claims 1 - 9.