Intelligent drug delivery and release system based on microfluidic technology

Abstract

The invention discloses an intelligent drug delivery and release system based on a micro-fluidic technology, which comprises a micro-fluidic chip, a fluid chip used for accurately controlling and analyzing a micro volume, a micro-machined channel and a micro-machined cavity, a liquid medicine storage device used for mixing, separating, reacting and detecting fluids on a micro scale, a liquid medicine storage device used for storing and managing drugs and a liquid medicine release device used for releasing the drugs. A micro-cavity is arranged in the body, a total liquid storage device and a fluid control module are arranged on the outer side of the body and used for accurately controlling the flowing and releasing speed of a medicine solution, and a monitoring sensor is used for monitoring concentration indexes of medicine in the body of a patient in real time and used for monitoring physiological parameters and medicine concentration; the micro-fluidic chip, the liquid medicine storage device, the fluid control module, the monitoring sensor, the control module, the power supply module and the connecting pipeline are matched for use, the liquid medicine storage device and the fluid control module obtain the medicine concentration, the release amount and the conveying rate of the medicine are calculated, and it can be guaranteed that the medicine concentration of a diseased area is stable.

Description

Technical Field

[0001] The present invention relates to the technical field of intelligent drug delivery, and particularly to an intelligent drug delivery and release system based on microfluidic technology. Background Art

[0002] Microfluidic technology is a technology for manipulating fluids at the micron scale, which allows precise manipulation and analysis of fluids. Drug release mechanisms include passive release, active release, and triggered release, etc. Passive release depends on the diffusion rate of the drug, active release controls the drug release through external stimuli such as light, heat, and electricity, and triggered release activates the drug release through specific physiological signals such as pH changes and enzyme activity. Microfabrication technology is the basis for manufacturing microfluidic chips, including technologies such as lithography, etching, injection molding, and soft lithography. These technologies can manufacture chips with complex microstructures, deliver an appropriate amount of drug to the correct position at the appropriate time, thereby increasing the utilization efficiency of the drug, improving the curative effect, reducing costs, and reducing toxic and side effects. The intelligent delivery system can automatically adjust the drug release rate and dose according to physiological signals or external instructions.

[0003] In the existing document 202311027766.4, it is impossible to inject drugs into patients so that the drugs reach the diseased area, thus achieving a therapeutic effect. There is no control over drug injection, resulting in a poor therapeutic effect, a large fluctuation range, low stability, and low precision during the control process, and automated control cannot be achieved. Therefore, the present invention proposes an intelligent drug delivery and release system based on microfluidic technology to solve the problems existing in the prior art. Summary of the Invention

[0004] In view of the above problems, the object of the present invention is to propose an intelligent drug delivery and release system based on microfluidic technology.

[0005] To achieve the object of the present invention, the present invention is realized through the following technical solutions: An intelligent drug delivery and release system based on microfluidic technology, comprising a microfluidic chip for precisely manipulating and analyzing fluids in a tiny volume, which contains microfabricated channels and chambers for fluid mixing, separation, reaction, and detection at the microscale;

[0006] A liquid medicine reservoir for storing and managing drugs, with a microchamber inside and a total reservoir outside;

[0007] A fluid control module for precisely controlling the flow and release rate of the drug solution;

[0008] A monitoring sensor for real-time monitoring of the drug concentration index in the patient's body to monitor physiological parameters and drug concentration for real-time adjustment of drug release;

[0009] A control module, which is used to control the microfluidic chip to control the delivery rate of the drug delivery device according to the set drug concentration range when receiving signals from the monitoring sensor;

[0010] A power supply module, which provides power for the system. The battery is an internal battery and is charged through an external power supply;

[0011] A connecting pipeline, which is used to connect the microfluidic chip with the liquid medicine reservoir and the fluid control module to ensure the smooth flow of the fluid.

[0012] A further improvement lies in that: the microfluidic chip mainly consists of a main chip, a fluid control module, a signal acquisition module and an external control module. The main chip is a kind of microchannel network, which includes microchannels, microvalves and micropumps. The fluid control module is responsible for the input, output and control of the fluid. The signal acquisition module is used to acquire the signals of the sensor, and the external control module is used to control the overall operation of the chip.

[0013] A further improvement lies in that: the drug stored in the liquid medicine reservoir is a nano-carrier drug, which is used to carry the drug. The nano-carrier is a liposome, a polymer nanoparticle or a metal nanoparticle.

[0014] A further improvement lies in that: the fluid control module includes a processor and a memory. The processor is used to process the data of the concentration sensor and generate control instructions, and the memory is used to store the preset drug concentration range and control algorithm.

[0015] A further improvement lies in that: the monitoring sensor controls the release of the drug, calculates the required drug release amount and delivery rate according to the set data and the set drug concentration range, and generates corresponding control instructions.

[0016] A further improvement lies in that: the control module automatically adjusts the delivery rate of the drug delivery device according to the real-time data of the monitoring sensor, and an alarm system is arranged inside the control module to issue an alarm when the drug concentration exceeds the set range.

[0017] A further improvement lies in that: the power supply module is a lithium-ion battery used to store electrical energy, which is used to control the charging and discharging process of the battery, protect the battery from overcharging, over-discharging and short-circuit damage, and provide a stable voltage output.

[0018] A further improvement lies in that: the connecting pipeline is made of a flexible and biocompatible material, and the material is polydimethylsiloxane and polytetrafluoroethylene. The connecting pipeline is used to transport the drug solution from the reservoir to the inlet of the microfluidic chip and transport the processed fluid from the chip to the target site.

[0019] A further improvement lies in that: the monitoring sensor is connected to the fluid control module through a wireless communication module to facilitate data transmission and system control.

[0020] A further improvement lies in that: the system includes a user interface for displaying real-time drug concentration data and system status and allowing input and adjustment of the drug concentration range; the system includes a data recording module for recording historical data of drug concentration and delivery parameters to facilitate subsequent analysis and optimization; the system has a remote monitoring function that allows remote monitoring and control of the drug delivery process through a network.

[0021] The beneficial effects of the present invention are as follows: Through the coordinated use of a microfluidic chip, a liquid medicine reservoir, a fluid control module, a monitoring sensor, a control module, a power supply module, and connecting pipelines, the drug concentration obtained by the liquid medicine reservoir and the fluid control module is used to calculate the drug release amount and delivery rate, which can ensure the stability of the drug concentration in the diseased area. The present invention monitors the drug concentration through the monitoring sensor and provides feedback to ensure safety during the drug delivery process, and real-time monitors physiological parameters and drug concentration, enabling the system to adjust drug release according to the actual needs of the body. The system can control the drug release mode through programming to adapt to different treatment needs and achieve personalized medicine. The closed design of the system and the use of biocompatible materials reduce the risk of infection and improve overall safety. By using multiple modules to control the flow rate of different liquid medicines for different patients, the final real-time release rate is obtained, making the released liquid medicine more accurate. Through the control module, the time delay when changing the concentration in the diseased area can be eliminated as much as possible, making the drug delivery system more stable. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0023] Figure 1 It is a schematic structural diagram of the system of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0025] In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection" and "linkage" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0026] In Document 202311027766.4, the stability of aptamers in cell culture medium can be enhanced. The multivalent linkage and synergistic effect of tetrahedral carriers increase the affinity of aptamers for their targets. And through framework nucleic acids, aptamers can enter cells to exert their biological activity and inhibit cancer cell proliferation. Moreover, more molecules such as fluorescent labels, siRNAs, polypeptides, antibodies or other anti-cancer drugs can be simultaneously linked to dendritic framework nucleic acids and transported to cells for synergistic therapy. And based on previous research, by patterning aptamers with multicolor fluorescence labels, precise and synergistic release of multiple drug molecules in specific regions can be achieved. However, there is no control over drug injection, resulting in poor treatment effects. On the other hand, during the control process, the fluctuation range is large, the stability is low, and the precision is low, and automated control cannot be achieved. In the invention, through the mutual cooperation of a microfluidic chip, a liquid medicine reservoir, a fluid control module, a monitoring sensor, a control module, a power supply module and connecting pipelines, precise micro-control delivery of drugs is carried out to complete the treatment of patients, greatly improving the practicability and functionality of the system.

[0027] According to Figure 1 As shown, this embodiment provides a drug intelligent delivery and release system based on microfluidic technology, including a microfluidic chip for precisely manipulating and analyzing fluids in a tiny volume, which contains microfabricated channels and chambers for fluid mixing, separation, reaction and detection at the microscale;

[0028] A liquid medicine reservoir for storing and managing drugs, with a microchamber inside and a total reservoir outside;

[0029] A fluid control module for precisely controlling the flow and release rate of the drug solution;

[0030] A monitoring sensor for real-time monitoring of drug concentration indicators in the patient's body to monitor physiological parameters and drug concentration for real-time adjustment of drug release;

[0031] A control module for controlling the microfluidic chip to control the delivery rate of the drug delivery device according to the set drug concentration range when receiving signals from the monitoring sensor;

[0032] A power supply module that provides power for the system and charges an internal battery via an external power supply;

[0033] A connecting pipeline that is used to connect the microfluidic chip with the liquid medicine reservoir and the fluid control module to ensure the smooth flow of the fluid.

[0034] The microfluidic chip mainly consists of a main chip, a fluid control module, a signal acquisition module, and an external control module. The main chip is a kind of microchannel network, which includes microchannels, microvalves, and micropumps. The fluid control module is responsible for the input, output, and control of the fluid. The signal acquisition module is used to collect the signals of the sensors. The external control module is used to control the overall operation of the chip. The drug is stored in the microchambers of the microfluidic chip and is released into the fluid channels as needed. Through the micropumps and microvalves, the system precisely controls the flow and mixing of the drug solution.

[0035] The drug stored in the liquid medicine reservoir is a nano-carrier drug for transporting the drug. The nano-carrier is a liposome, a polymer nanoparticle, or a metal nanoparticle.

[0036] The fluid control module includes a processor and a memory. The processor is used to process the data of the concentration sensor and generate control instructions. The memory is used to store the preset drug concentration range and control algorithms. It controls the flow direction of the drug in the microfluidic chip through the microvalve to achieve multi-path selection or shunting. In case of need, it controls the mixing of the drug with other solutions or reagents for chemical reactions in the chip, and adjusts the pressure in the system to prevent leakage caused by blockage or excessive pressure.

[0037] The monitoring sensor controls the controlled release of the drug, calculates the required drug release amount and delivery rate according to the set data and the set drug concentration range, and generates corresponding control instructions. The monitoring sensor monitors physiological signals, including pH value, temperature, and ion concentration. These signals are used to trigger the release of the drug. The drug is released to the target tissue or organ through the outlet of the microfluidic chip. The sensor can detect the drug concentration in the blood or tissue to ensure that the drug is maintained within the therapeutic window, neither excessive nor insufficient. The sensor senses the changes in the external environment to judge the impact on the drug stability and release rate. The sensor can also monitor the performance of the microfluidic system, including flow rate and pressure, to ensure that the system works as expected, and promptly discovers and corrects any deviations or faults to achieve local or systemic treatment.

[0038] The control module automatically adjusts the delivery rate of the drug delivery device according to the real-time data of the monitoring sensor, and sends instructions to the micropump and microvalve to accurately control the release of the drug. The control module is used to open or close the valve, adjust the speed of the pump, and provide a user interface to allow medical personnel or patients to input treatment parameters, view system status and receive alarms. It continuously monitors the operating status of the entire system, including the drug storage volume, the status of the fluid path and the integrity of the system. An alarm system is set inside the control module to sound an alarm when the drug concentration exceeds the set range.

[0039] The power module is a lithium-ion battery used to store electrical energy, control the battery's charge and discharge process, protect the battery from overcharge, over discharge and short circuit, and provide a stable voltage output.

[0040] The connecting pipeline is made of a flexible and biocompatible material, such as polydimethylsiloxane or polytetrafluoroethylene, and is used to transport the drug solution from the reservoir to the inlet of the microfluidic chip and to transport the treated fluid from the chip to the target site.

[0041] The monitoring sensor is connected to the fluid control module via a wireless communication module to facilitate data transmission and system control.

[0042] The system includes a user interface, which displays real-time drug concentration data and system status through the user interface display screen, and adjusts the input and adjusts the drug concentration range through control buttons. The system includes a data recording module for recording historical data of drug concentration and delivery parameters to facilitate subsequent analysis and optimization, and records the drug release conditions of different patients each time. The system has a remote monitoring function, allowing remote monitoring and control of the drug delivery process through the network.

[0043] When the microfluidic-based intelligent drug delivery and release system is used, the system is started and an initialization check is performed to ensure the normal operation of all components including the micropump, sensor and control unit. When the drug solution is injected into the drug reservoir, it is ensured that the drug is connected to the inlet of the microfluidic chip. The parameters of drug release, including release rate, dosage and time interval, are set through the user interface. According to the characteristics of the drug and treatment needs, the system is calibrated to ensure the accuracy of drug release. The micropump and microvalve are activated to start releasing the drug according to the set parameters. The sensor monitors physiological parameters and drug concentration in real time, and the data is fed back to the control unit. The control unit dynamically adjusts the drug release strategy according to the real-time monitoring data to adapt to physiological changes or treatment needs. During the entire treatment process, the system status and patient response are continuously monitored to ensure safe and effective treatment. After the scheduled treatment cycle is completed, the drug release is stopped and the system is turned off. After the treatment is completed, the system is cleaned and maintained in preparation for the next use.

[0044] The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the art should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug intelligent delivery and release system based on microfluidic technology, characterized in that, Including a microfluidic chip, a chip for precisely manipulating and analyzing fluids in a tiny volume, which contains microfabricated channels and chambers for fluid mixing, separation, reaction, and detection at the microscale; A liquid medicine reservoir for storing and managing drugs, with a microchamber inside and a main reservoir outside; A fluid control module for precisely controlling the flow and release rate of the drug solution; A monitoring sensor for real-time monitoring of the drug concentration index in the patient's body to monitor physiological parameters and drug concentration for real-time adjustment of drug release; A control module for controlling the microfluidic chip to control the delivery rate of the drug delivery device according to the set drug concentration range when receiving a signal from the monitoring sensor; A power supply module for providing power to the system, with the battery being an internal battery and charged through an external power supply; A connecting pipeline for connecting the microfluidic chip with the liquid medicine reservoir and the fluid control module to ensure smooth fluid flow.

2. The intelligent drug delivery and release system based on microfluidic technology according to claim 1, characterized in that: The microfluidic chip mainly consists of a main chip, a fluid control module, a signal acquisition module, and an external control module. The main chip is a microchannel network, which includes microchannels, microvalves, and micropumps. The fluid control module is responsible for fluid input, output, and control. The signal acquisition module is used to collect sensor signals, and the external control module is used to control the overall operation of the chip.

3. The intelligent drug delivery and release system based on microfluidic technology according to claim 1, characterized in that: The drug stored in the liquid medicine reservoir is a nano-carrier drug for transporting the drug, and the nano-carrier is a liposome, a polymer nanoparticle, or a metal nanoparticle.

4. The intelligent drug delivery and release system based on microfluidic technology according to claim 1, wherein: The fluid control module includes a processor and a memory. The processor is used to process data from the concentration sensor and generate control instructions, and the memory is used to store the preset drug concentration range and control algorithms.

5. The drug intelligent delivery and release system based on microfluidic technology according to claim 1, wherein: The monitoring sensor controls the release of the drug, calculates the required drug release amount and delivery rate according to the set data and the set drug concentration range, and generates corresponding control instructions.

6. A drug intelligent delivery and release system based on microfluidic technology according to claim 1, characterized in that: The control module automatically adjusts the delivery rate of the drug delivery device according to the real-time data of the monitoring sensor, and an alarm system is set inside the control module to issue an alarm when the drug concentration exceeds the set range.

7. A drug intelligent delivery and release system based on microfluidic technology according to claim 1, characterized in that: The power supply module is a lithium-ion battery for storing electrical energy, used to control the charging and discharging process of the battery, protect the battery from overcharging, over-discharging, and short-circuit damage, and provide a stable voltage output.

8. The intelligent drug delivery and release system based on microfluidic technology according to claim 1, wherein: The connecting pipeline is made of a flexible and biocompatible material, which is polydimethylsiloxane and polytetrafluoroethylene. The connecting pipeline is used to transport the drug solution from the reservoir to the inlet of the microfluidic chip and transport the processed fluid from the chip to the target site.

9. The drug intelligent delivery and release system based on microfluidic technology according to claim 1, characterized in that: The monitoring sensor is connected to the fluid control module through a wireless communication module for convenient data transmission and system control.

10. A drug intelligent delivery and release system based on microfluidic technology according to claim 1, characterized in that: The system includes a user interface for displaying real-time drug concentration data and system status and allowing input and adjustment of the drug concentration range. The system includes a data recording module for recording historical data of drug concentration and delivery parameters for subsequent analysis and optimization. The system has a remote monitoring function, allowing remote monitoring and control of the drug delivery process through the network.

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