Two-component wine
By providing two-component wine and combining strict drug efficacy testing methods, the problem of poor results of existing alcohol-resistant products is solved, and the effect of effectively reducing or avoiding alcoholic damage during drinking is achieved.
Patent Information
- Application Number
- CN202510555093.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-29
- Publication Date
- 2025-07-22
AI Technical Summary
Existing alcoholic alcohol products cannot effectively avoid or reduce alcoholic damage, and the current testing methods cannot select drug prescriptions with leading effects.
Two-component wine is provided, consisting of alcohol-containing beverage wine and wine-suppressing components. The wine-suppressing components are Western medicines, Chinese medicines and their extracts allowed by the state. They are mixed and consumed after packing, and strict drug efficacy testing methods are used to ensure the effect.
Without affecting the taste of alcohol, alcohol damage will be significantly reduced or avoided. The preferred type of drug is increased to 23, and the test effect will be reduced to the level of liver damage, achieving a disruptive breakthrough.
Smart Images
Figure CN120349839A_ABST
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of beverage wine in industrial food, and in particular relates to two-component wine. Background Art
[0002] According to recent reports, the number of deaths caused by alcohol consumption has risen to about 3 million per year worldwide. According to the record of "detoxification" in the "Ben Jing" written 220 years ago, detoxification has been a major problem that has troubled the global medical community for more than a thousand years. From the hundreds of drugs that Western medicine claims to "protect against alcoholic liver damage", it can be seen that this is by no means due to the lack of appropriate drugs. The bottom line is:
[0003] First of all, the classic recipe for hangover relief is the Kudzu Flower Soup which originated in the early Ming Dynasty and has been used for thousands of years. Just from the word "hangover relief", we can tell that it is a typical case of giving an umbrella after the rain to cure the symptoms.
[0004] Secondly, medicine has dosage limits, but drinking is unlimited. For example, the turmeric and pueraria root used in hangover products on the market have a maximum dosage of 10g and 15g respectively. The active ingredients curcumin and puerarin, even if the highest content reported is 5% and 0.477% respectively, each dose contains only 0.5g and 0.72g of active ingredients. According to the average alcoholic who drinks 200ml of wine containing 40% alcohol each time, it is only 0.82% and 1.18% of the harmful alcohol. Since medication cannot be overdosed, the effect of selecting one to a dozen drugs in the same way as usual treatment is of course a drop in the bucket.
[0005] Finally, the current evaluation of the effectiveness of medicines and health foods respectively tests the protective effect and auxiliary protection function on alcoholic liver damage. The former refers to the "Pharmacological Experimental Methods" and tests 8 items including malondialdehyde (MDA), glutathione (GSH), triglycerides (TG), pathological tissue, serum transaminases (ALT and AST), peroxidase (SOD) and liver index; the latter has national standards, namely the "Health Food Function Test and Evaluation Methods" (2023 edition) implemented at that time, Article 22 "Test Methods for Auxiliary Protective Effects on Chemical Liver Damage" in the second scheme of the alcoholic liver injury model, which only tests the first 4 items to determine whether there is an auxiliary protection function for alcoholic liver damage. There is no comparison of the damage reduction level, and it is impossible to select the leading drug formulation.
[0006] As a result, the hangover relieving products on the market, such as those summarized by Zhuo Xinxin et al. in "Research Progress on the Mechanism of Hangover Relief and Hangover Relief Products", include HerbSense hangover relieving tablets from Australia, RU-21 hangover relieving tablets from the United States, FANCL Turmeric Revolution from Japan, RcadyQ from South Korea, and Neptune Jinzun from China, which are all dietary supplements. The drugs used are concentrated in 3 to 5 types, and there is no brand that is widely recognized and convincing to the public. Summary of the invention
[0007] The object of the present invention is to provide a double-component liquor, which can avoid or reduce the harm of drinking.
[0008] The object of the present invention can be achieved by the following technical solutions:
[0009] The present invention provides a double-component liquor, which is composed of a liquor component and an alcohol-inhibiting component.
[0010] Further, the liquor component is an alcoholic beverage, including but not limited to Chinese liquor, whisky, vodka, brandy, wine, beer, etc.
[0011] Further, the alcohol-inhibiting component is a beverage prepared from Western medicines, traditional Chinese medicines and their extracts that are selected from the drugs currently known as "having a protective effect on alcoholic liver injury" or "having an auxiliary protective function on alcoholic liver injury" and are permitted to be used by the state to inhibit alcoholic injury.
[0012] Further, the alcohol content of the liquor component is 0.5 - 100 ml. By controlling the alcohol content of the liquor component, the effect of inhibiting alcoholic injury is improved.
[0013] Further, the number of types of drugs used in the alcohol-inhibiting component is 1 - 80.
[0014] Further, in the preparation of the double-component liquor, the liquor component and the alcohol-inhibiting component are separately packaged first, and then put into the same packaging box or the same packing case for combined drinking.
[0015] Further, when the alcohol-inhibiting component uses Western medicines, traditional Chinese medicines or extracts of traditional Chinese medicines, it is obtained through drug selection, traditional Chinese medicine extraction, efficacy testing and dilution and packaging.
[0016] Further, the steps of the traditional Chinese medicine extraction are as follows:
[0017] S1. Weigh the Chinese medicine decoction pieces of the selected Chinese medicine varieties according to the medium dose in the Chinese Pharmacopoeia or the Chinese Materia Medica. Put the Chinese medicine decoction pieces containing volatile oil into the steam distillation extractor, and put the Chinese medicine decoction pieces without volatile oil into the extraction tank. Inject 5 - 6 times the weight of the decoction pieces of water respectively, and soak for 1 - 2 h;
[0018] S2. Heat the distillation extractor to distill out the volatile oil and store it separately. The distilled water, the medicinal residues and the unevaporated water are incorporated into the extraction tank;
[0019] S3. Heat the extraction tank to keep it boiling gently for 40 min, and filter out the first extraction solution and store it in the temporary storage tank;
[0020] S4. Inject 4 - 5 times the weight of the decoction pieces of water into the extraction tank, heat it to keep it boiling gently for 40 min, filter out the second extraction solution, and combine it with the first extraction solution;
[0021] S5. Inject water into the extraction tank at 4 - 5 times the weight of the Chinese herbal pieces, heat to a gentle boil and maintain for 40 min, filter out the third extraction solution, combine it with the first and second extraction solutions, and mix well by stirring at 500 - 1500 r / min for 1 - 3 min;
[0022] S6. Add clarifying agent at 0.01 - 10% of the mass of the extraction solution to the mixed extraction solution, stir well for 1 - 3 min, and let it stand for 2 - 36 h;
[0023] S7. Screen the extraction solution after standing through a sieve with 40 - 500 meshes, centrifuge at 10000 - 16000 r / min, and concentrate it by reverse osmosis with a membrane pore size of 0.0001 μm, removing 20 - 60% of the water;
[0024] S8. Transfer it to a vacuum concentration tank, add the volatile oil separately stored in S2 after concentration, and form a fluid extract with a liquid medicine ratio of 1﹕1.1 - 1.9.
[0025] Furthermore, the method for efficacy test is as follows:
[0026] The two - component wine is a food. Generally, foods do not undergo efficacy tests. Here, we test the effect of inhibiting alcoholic damage. Based on the standards, it can be more stringent than the national standards. Referring to the second - twenty - second article "Test method for auxiliary protection function against chemical liver injury" in "Functional Test and Evaluation Method of Health Foods" (2023 Edition), a model of alcoholic liver injury is used with rats at high, medium, and low doses. The medium dose is the medium dose in "Chinese Pharmacopoeia" or "Compendium of Chinese Materia Medica", and the high and low doses are respectively increased and decreased by 20%. When the liver section diagram shows that "the hepatic lipid vacuoles in the medium - dose group are significantly reduced, and the hepatic lipid vacuoles of some animals basically disappear", it is determined to be qualified.
[0027] Furthermore, the method for dilution and packaging is as follows:
[0028] Dilute the fluid extract extracted from traditional Chinese medicine with pure water to 670 ml per portion, mix well by stirring at 500 - 1500 r / min for 1 - 3 min, centrifuge at 10000 - 16000 r / min, and then package. Each portion is packaged in 2 aluminum cans of 335 ml.
[0029] The beneficial effects of the present invention:
[0030] (1) Invent a new type of wine - the two - component wine. By drinking the alcohol - inhibiting component in combination with the wine, it can take effect immediately without affecting the drinking taste of the wine, achieving a subversive breakthrough of treating the root cause like sending charcoal in the snow, and completely solving the problem that has persisted for thousands of years of treating the symptoms like sending an umbrella after the rain.
[0031] (2) Optimize the variety of drugs used to meet the requirement of inhibiting alcoholic damage caused by alcohol components. The number of drug varieties is increased from 3 - 5 types in current market - available hangover products to 23 types in the examples. The effect is to avoid or reduce alcoholic damage, thus completely eliminating the problem that current unlimited alcohol consumption cannot be addressed due to the limited dosage of drugs.
[0032] (3) Improve the current test for the auxiliary protection function against alcoholic liver damage to a test for liver damage level, so as to optimize drugs with leading effects and completely eliminate the problem that currently it is impossible to select a drug formula with leading effects.
[0033] Therefore, from treating the symptoms of hangover that has continued for thousands of years, it has leaped to treating the root cause of inhibiting alcoholic damage, achieving a disruptive breakthrough. From the ineffective hangover method with little effect, it has leaped to avoiding or reducing the harm of alcohol consumption. BRIEF DESCRIPTION OF THE DRAWINGS
[0034] The drawing is a sectional view of the liver tissue of Example 1 of the present invention magnified 400 times. DETAILED DESCRIPTION OF THE INVENTION
[0035] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.
[0036] Example 1
[0037] In this example, liquor with 56 ml of alcohol is used as the alcohol component, and a two - component liquor is produced according to the following steps:
[0038] Step 1: Preparation of the alcohol component
[0039] Purchase Beijing Niulanshan Erguotou liquor with an alcohol content of 56%, and divide it into 1 bottle, with a total of 120 ml, to make the alcohol component.
[0040] Step 2: Preparation of the alcohol - inhibiting component
[0041] (1) Drug optimization
[0042] From drugs for inhibiting alcoholic damage, namely currently known Western medicines, traditional Chinese medicines and their extracts with "protective effect on alcoholic liver damage" and "auxiliary protective function on alcoholic liver damage", 21 kinds of traditional Chinese medicines including seabuckthorn, coix seed, mung bean, tangerine peel, rose hip, buckwheat, pepper, turmeric, black wolfberry, chili, poria cocos, mulberry, fennel, lotus leaf, phyllanthus emblica, pomelo peel, shiitake mushroom, ganoderma lucidum, cinnamon, fresh reed rhizome, hawthorn and houttuynia cordata are optimized, as well as 1 kind of Western medicine taurine listed as a nutritional fortifier and 1 kind of traditional Chinese medicine extract sucralose (the primary raw material is sugarcane) listed as a food additive.
[0043] According to the dosages in the Chinese Pharmacopoeia and the Compendium of Chinese Materia Medica, for each portion of the alcohol-inhibiting component, weigh: 7 g of seabuckthorn, 20 g of coix seed, 20 g of mung bean, 7 g of tangerine peel, 10 g of roselle, 20 g of buckwheat, 10 g of pepper, 7 g of turmeric, 10 g of black wolfberry, 10 g of chili pepper, 12 g of poria, 12 g of mulberry, 5 g of fennel, 7 g of lotus leaf, 6 g of phyllanthus emblica, 7 g of pomelo peel, 7 g of shiitake mushroom, 9 g of ganoderma lucidum, 3 g of cinnamon, 40 g of fresh reed rhizome, 10 g of hawthorn, and 20 g of houttuynia cordata.
[0044] (2) Traditional Chinese medicine extraction
[0045] Weigh the above-mentioned medicines according to 100 portions of the alcohol-inhibiting component. Put the tangerine peel, pepper, chili pepper, fennel, pomelo peel, and cinnamon containing volatile oils into a steam distillation extractor, and put the other traditional Chinese medicines without volatile oils into an extraction tank. Inject 6 times the weight of water of the medicines respectively and soak for 2 h.
[0046] Heat and distill the volatile oils in the steam distillation extractor and store them separately. The distilled water, medicine residues, and the undistilled water are incorporated into the extraction tank.
[0047] Heat the extraction tank to keep it slightly boiling for 40 min, and filter out the first extraction solution and store it in a temporary storage tank.
[0048] Inject 5 times the weight of water of the cut crude drugs into the extraction tank again, heat it to keep it slightly boiling for 40 min, filter out the second extraction solution, and merge it with the first extraction solution.
[0049] Inject 5 times the weight of water of the cut crude drugs into the extraction tank again, heat it to keep it slightly boiling for 40 min, filter out the third extraction solution, merge it with the first and second extraction solutions, and stir at 1200 r / min for 2 min to mix evenly.
[0050] Add 0.5% of ZTC1+1 natural clarifying agent based on the mass of the extraction solution to the mixed and evenly extracted solution, stir for 3 min to mix evenly, and let it stand for 6 h.
[0051] Sieve the standing extraction solution through a 300-mesh sieve, centrifuge it at 16000 r / min, and then perform reverse osmosis concentration with a reverse osmosis membrane with a pore size of 0.0001 μm to remove 40% of the water.
[0052] Transfer it to a vacuum concentration tank, concentrate it into a fluid extract with a liquid medicine ratio of 1:1.1 after adding the separately stored volatile oils, 0.2 g of taurine per portion, and 87 mg of sucralose.
[0053] (3) Efficacy test
[0054] Refer to the standard "Methods for Function Testing and Evaluation of Health Foods" (2023 Edition), and improve the current test for whether there is an adjuvant protective effect on alcoholic liver injury into a test for the level of inhibiting alcoholic liver injury.
[0055] The experimental rats were divided into 5 groups: normal group, model group, high-dose group, medium-dose group, and low-dose group, with 10 rats in each group, half male and half female. Beijing Niulanshan Erguotou liquor with an alcohol content of 56% was purchased from the market. The experimental rats in the model group, high-dose group, medium-dose group, and low-dose group were fed with the liquor at a dose of 11 ml / kg / d (equivalent to 68.4 ml for an adult, higher than the 67.2 ml of the liquor component, which can better illustrate the reliability of the detected effect) for 12 weeks. The normal group was fed with distilled water of equal volume. In the high-dose group, medium-dose group, and low-dose group, while the experimental rats were fed with the liquor, the anti-alcohol component fluid extract was intragastrically administered twice. The adult dosage was converted into the rat dosage according to the equivalent dose, which were 2.7 ml / kg, 2.25 ml / kg, and 1.8 ml / kg in sequence. The blank control group and the model group were intragastrically administered with distilled water of equal volume to replace the fluid extract.
[0056] Referring to the second method "Test method for auxiliary protection function against chemical liver injury" in Article 22 of "Functional Test and Evaluation Method of Health Foods" (2023 Edition), the alcohol-induced liver injury model in Scheme 2 was used to make liver pathological sections as attached Figure 1 as shown.
[0057] Attached Figure 1 It shows that the hepatic lobule structure of the normal group is normal, the hepatocytes are relatively large in volume, arranged closely and regularly, without lipid droplet accumulation, and no inflammatory cells are seen. In the model group, the hepatic lobule structure of the rats' liver is incomplete, the hepatocytes are fragmented, arranged loosely, the cell nuclei are shrunk, a large number of fatty vacuole lesions appear and are scattered throughout the field of view, and focal necrosis of hepatocytes can be seen in some parts of the liver, with inflammatory cell infiltration. The effects of the high and medium-dose groups in this example are basically similar. The degree of liver tissue injury in rats is reduced, the number of fatty vacuoles is significantly reduced, the volume is decreased, the number of fragmented and inflammatory hepatocytes is reduced, the shape of hepatocytes is relatively regular, and the hepatic fat vacuoles of some animals basically disappear. The effect of the low-dose group is weaker. It fully shows that PI3 formula (the code of the anti-alcohol component in this example) has a good effect on reducing alcoholic liver injury.
[0058] The current test can only have a protective effect or an auxiliary protection function. The pathological sections in this example show that the hepatic fat vacuoles of some animals basically disappear, achieving the effect of completely inhibiting alcoholic liver injury in some animals, and have a good effect on reducing alcoholic liver injury, fully indicating that the effect of the optimized anti-alcohol component has reached a leading level. Judging from the similar efficacy of the high and medium doses, there is no need to increase the dose of the fluid extract of the anti-alcohol component to avoid the aggravation of the medicine taste.
[0059] (4) Dilution and sub-packaging
[0060] Take the fluid extract and dilute it with pure water to 670 ml per portion, stir for 2 minutes at 1200 r / min to mix evenly, centrifuge at 16000 r / min, and then sub-package it into aluminum cans with a capacity of 335 ml.
[0061] Step 3: Packaging of two-component wine
[0062] Place 1 bottle of the separated wine component and 2 cans of the wine-suppressing component into the same packaging box, or pack them into the same packing case according to this ratio.
[0063] Examples 2 - 7
[0064] Use beverage wine of other wine types to make two-component wine. The alcohol content of the wine component and the wine-suppressing component are the same as in Example 1. The difference is that according to the alcohol content in Example 1, adjust the consumption of the wine component as shown in Table 1:
[0065] Table 1
[0066] Item Wine variety Alcohol content % Dosage of wine components Example 2 Chinese liquor 40 168 Example 3 Chinese liquor 28 240 Example 4 Whisky 42 160 Example 5 Vodka 60 112 Example 6 Brandy 43 156 Example 7 Wine 13 516
[0067] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.
[0068] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. Two-component wine, characterized in that, The two-component wine is composed of a wine component and an alcohol-inhibiting component.
2. The two-component wine according to claim 1, characterized in that, The wine component is an alcoholic beverage such as Chinese liquor, whisky, vodka, brandy, or wine.
3. The two-component wine according to claim 1, wherein, The alcohol-inhibiting component is a beverage made from Western medicines, traditional Chinese medicines, and their extracts that are selected from drugs currently known as having a "protective effect on alcoholic liver injury" or an "auxiliary protective function on alcoholic liver injury" and are permitted for use in the country to inhibit alcoholic injury.
4. The two-component wine according to claim 1, characterized in that, The alcohol content of the wine component is 0.5 - 100 ml.
5. The two-component wine according to claim 1, characterized in that, The number of drug types in the alcohol-inhibiting component is 1 - 80.
6. The two-component wine according to claim 1, wherein In the preparation of the two-component wine, the wine component and the alcohol-inhibiting component are separately packaged first and then placed in the same packaging box or the same packing case for paired consumption.