Filtering device for antibody screening

Abstract

The invention relates to the technical field of medicine production equipment, in particular to an antibody screening and filtering device which comprises a base, a filtering box, a feeding port, a filtering mechanism, a driving mechanism, a cleaning mechanism and a backwashing mechanism, the filtering box is fixedly installed on the base, the feeding port is fixedly installed on the filtering box, and the filtering mechanism is fixedly installed on the filtering box; the filtering mechanism is used for filtering antibodies in the filtering box, the cleaning mechanism and the backwashing mechanism are fixedly mounted on the driving mechanism, the cleaning mechanism is used for cleaning the filtering mechanism, the backwashing mechanism is used for backwashing the filtering mechanism, and the driving mechanism can be mounted on the filtering box in a sliding manner. According to the antibody screening and filtering device, through the arrangement of the filtering mechanism and the driving mechanism, the position of the filter membrane can be adjusted, so that subsequent antibodies can be filtered on the clean filter membrane surface, and the use effect and the working efficiency of the antibody screening and filtering device are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical production equipment, and particularly relates to an antibody screening and filtering device. Background Art

[0002] The basic structure of an antibody is a four-peptide chain structure formed by two identical heavy chains and two identical light chains connected by interchain disulfide bonds. The amino-terminal region of the heavy and light chains, approximately 110 amino acid sequences, varies greatly and is called the variable region, which can specifically recognize antigens; the carboxyl-terminal region of the heavy and light chains has relatively stable amino acid sequences and is called the constant region. Different types of antibodies have different constant regions and can mediate various biological functions.

[0003] An antibody screening and filtering device is a filtering device for antibody screening. A mixed solution containing antibodies enters the filtering device through a feed port. Under the action of a pressure system, the solution is pressed towards the filtering unit. Antibody molecules can pass through the filter membrane, while impurities, unreacted raw materials, cell debris, etc. are retained on the surface of the filter membrane or in front of the filter membrane, thereby realizing the separation of antibodies from impurities. The filtered antibody solution is collected through a discharge port, and the impurities retained on the filter membrane can be regularly discharged through a slag discharge port.

[0004] Considering that when the existing antibody screening and filtering device is in use, it is necessary to filter impurities in the antibody through a filter membrane. After the filter membrane filters the antibody, impurities in the antibody are likely to block the pores of the filter membrane, resulting in a reduction in the antibody filtering effect and efficiency, and thus reducing the use effect and working efficiency of the antibody screening and filtering device. Summary of the Invention

[0005] The purpose of the present invention is to provide an antibody screening and filtering device.

[0006] To achieve this purpose, the present invention adopts the following technical solutions: Provide an antibody screening and filtering device, including a base, a filtering box, a feed port, a filtering mechanism, a driving mechanism, a cleaning mechanism, and a backwashing mechanism. The filtering box is fixedly installed on the base, the feed port is fixedly installed on the filtering box, the filtering mechanism is fixedly installed on the filtering box, and the filtering mechanism is used to filter the antibodies in the filtering box. Both the cleaning mechanism and the backwashing mechanism are fixedly installed on the driving mechanism. The cleaning mechanism is used to clean the filtering mechanism, and the backwashing mechanism is used to backwash the filtering mechanism. The driving mechanism is slidably installed on the filtering box, and the driving mechanism is used to drive the cleaning mechanism and the backwashing mechanism to move simultaneously.

[0007] Further, the filtering mechanism includes a bearing plate, a mounting frame, a synchronous belt, a cylindrical rod, a synchronous pulley and a filter membrane. The bearing plate is fixedly installed on the filtering box, the mounting frame is fixedly installed on the filtering box, the synchronous pulley is fixedly installed on the cylindrical rod, and the cylindrical rod penetrates through the mounting frame and the bearing plate. The filter membrane is fixedly installed on the synchronous belt, and the synchronous belt is slidably connected to the mounting frame and meshes with the synchronous pulley.

[0008] Further, the filtering mechanism further includes a hydraulic cylinder, a hydraulic plate and a liquid discharge hopper. The hydraulic cylinder is fixedly installed on the filtering box, the hydraulic plate is fixedly installed on the output end of the hydraulic cylinder, and the hydraulic plate is slidably connected to the bearing plate. The liquid discharge hopper is fixedly installed on the filtering box. The cylindrical rod is rotatably connected to the filtering box and is fixedly installed on the driving mechanism, and the driving mechanism is used to drive the cylindrical rod to rotate.

[0009] Further, the driving mechanism includes a bidirectional telescopic rod and a connecting rod. The bidirectional telescopic rod is rotatably installed on the filtering box through a hinge block, and a torsion spring is connected between the hinge block and the filtering box. The connecting rod is fixedly installed on the bidirectional telescopic rod. A chute is formed on the filtering box, and the bidirectional telescopic rod is slidably connected to the chute through a sliding column.

[0010] Further, the driving mechanism further includes a rack, a gear, a mounting rod, a mounting column and a unidirectional limiting mechanism. The mounting rod is hinged to the connecting rod through a moving rod, and the moving rod penetrates through the bearing plate. The rack is fixedly installed on the mounting rod and is slidably connected to the filtering box. The mounting column is fixedly installed on the cylindrical rod, the gear is rotatably installed on the mounting column and meshes with the rack, and the unidirectional limiting mechanism is fixedly installed on the filtering box and is used to limit the cylindrical rod in one direction.

[0011] Further, the unidirectional limiting mechanism includes a fixed ring and two wedge blocks. The fixed ring is fixedly installed on the filtering box and is rotatably connected to the mounting column. A second card slot is formed on the fixed ring, and a first card slot is formed on the gear. The two wedge blocks are respectively connected to the mounting column through two springs and are both slidably connected to the mounting column. The two wedge blocks are respectively clamped with the first card slot and the second card slot.

[0012] Further, the cleaning mechanism includes a hinge plate, a scraper, a fixed block and a T-shaped rod. The hinge plate is hingedly installed on the bearing plate, the scraper is fixedly installed on the bearing plate, the fixed block is fixedly installed on the bearing plate, and a guide groove is formed on the fixed block. The T-shaped rod is slidably installed in the guide groove.

[0013] Further, the cleaning mechanism further includes an L-shaped rod I, a fixing plate I and a discharge hopper. The fixing plate I is fixedly installed on the rack, and a first inclined groove is formed on the fixing plate I. The L-shaped rod I is fixedly installed on the T-shaped rod and is slidably connected to the first inclined groove. The discharge hopper is fixedly installed on the filtering box, and the L-shaped rod I penetrates through the discharge hopper.

[0014] Further, the backwashing mechanism includes a water tank, a box body, a spray head, a water pump and a water inlet pipe. The water tank is fixedly installed on the filter box, the box body is fixedly installed on the bearing plate, the water inlet pipe is fixedly installed on the box body, the water inlet pipe is communicated with the water tank through a delivery pipe, the water pump is fixedly installed on the box body, the spray head is fixedly installed on the box body, the input end of the water pump is communicated with the box body through a suction pipe, and the output end of the water pump is communicated with the spray head through a drain pipe.

[0015] Further, the backwashing mechanism further includes a second fixing plate, an L-shaped rod II, a rubber plug and a drain hopper. The second fixing plate is fixedly installed on the rack, a second inclined groove is formed in the second fixing plate, the rubber plug is fixedly installed on the L-shaped rod II, and the rubber plug is inserted into the water inlet pipe. The L-shaped rod II is slidably installed in the second inclined groove, and the L-shaped rod II penetrates through the bearing plate and the box body. The drain hopper is fixedly installed on the filter box.

[0016] The beneficial effects of the present invention: For this antibody screening and filtering device, through the provided filtering mechanism and driving mechanism, antibodies can be filtered, and after the filtering is completed, the position of the filter membrane can be adjusted so that subsequent antibodies can be filtered on a clean filter membrane surface, thereby improving the use effect and working efficiency of the antibody screening and filtering device. In addition, through the provided cleaning mechanism and backwashing mechanism, during the process of adjusting the position of the filter membrane, the filter membrane can be cleaned and backwashed, so as to separate and remove large-particle impurities and small-particle impurities on the filter membrane, so as to reuse the filter membrane, avoid clogging of the filter holes of the filter membrane, thereby improving the service life of the filter membrane and the use effect of the screening and filtering device. At the same time, through the cleaning mechanism, large-particle impurities on the filter membrane can be cleaned first, avoiding friction between the filter membrane and large-particle impurities during the process of moving and adjusting the position of the filter membrane, resulting in damage to the filter membrane and reducing the filtering performance of the filter membrane, and further improving the service life of the filter membrane and the use effect of the screening and filtering device. Description of the Drawings

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required to be used in the embodiments of the present invention.

[0018] Figure 1 It is a three-dimensional structural schematic diagram of the present invention; Figure 2 It is a schematic diagram of the internal structure of the filter box of the present invention; Figure 3 It is a front view structural schematic diagram of the filtering mechanism of the present invention; Figure 4 For the present invention Figure 3 The enlarged structural schematic diagram of part A therein; Figure 5 It is a sectional view structural schematic diagram of the filter box of the present invention; Figure 6Schematic front view structure of the driving mechanism of the present invention; Figure 7 Schematic exploded structure of the one-way limiting mechanism of the present invention; Figure 8 Schematic front view structure of the cleaning mechanism of the present invention; Figure 9 Schematic sectional view structure of the box body of the present invention; Figure 10 Schematic front view structure of the backwashing mechanism of the present invention.

[0019] In the figure: 1, base; 2, filter box; 3, feed inlet; 4, filtering mechanism; 41, hydraulic cylinder; 42, hydraulic plate; 43, bearing plate; 44, mounting frame; 45, synchronous belt; 46, cylindrical rod; 47, synchronous pulley; 48, liquid discharge hopper; 49, filter membrane; 5, driving mechanism; 51, bidirectional telescopic rod; 52, connecting rod; 53, hinge block; 54, chute; 55, moving rod; 56, rack; 57, gear; 58, one-way limiting mechanism; 581, fixed ring; 582, first card slot; 583, second card slot; 584, wedge block; 585, spring; 59, mounting rod; 510, sliding column; 511, torsion spring; 512, mounting column; 6, cleaning mechanism; 61, hinge plate; 62, scraper; 63, fixed block; 64, guide groove; 65, T-shaped rod; 66, first L-shaped rod; 67, first fixing plate; 68, first inclined groove; 69, discharge hopper; 7, backwashing mechanism; 71, water tank; 72, delivery pipe; 73, box body; 74, spray head; 75, water pump; 76, suction pipe; 77, drain pipe; 78, water inlet pipe; 79, second fixing plate; 710, second inclined groove; 711, second L-shaped rod; 712, rubber plug; 713, drainage hopper. Detailed implementation manners

[0020] The technical solution of the present invention will be further described below with reference to the accompanying drawings and through specific implementation manners.

[0021] Among them, the accompanying drawings are only for illustrative purposes, showing only schematic diagrams, not physical diagrams, and should not be construed as a limitation of this patent; in order to better illustrate the embodiments of the present invention, some components in the accompanying drawings will be omitted, enlarged or reduced, and do not represent the dimensions of the actual product.

[0022] Refer to Figure 1 and Figure 2, A kind of antibody screening and filtering device shown includes a base 1, a filtering box 2, a feed inlet 3, a filtering mechanism 4, a driving mechanism 5, a cleaning mechanism 6 and a backwashing mechanism 7. The filtering box 2 is fixedly installed on the base 1. The filtering box 2 is used for filtering antibodies, and three discharge ports are arranged on one side of the filtering box 2, corresponding to a liquid discharge hopper 48, a discharge hopper 69 and a drainage hopper 713 respectively. The feed inlet 3 is fixedly installed on the filtering box 2, and the feed inlet 3 is used for adding antibodies into the filtering box 2. The filtering mechanism 4 is fixedly installed on the filtering box 2, and the filtering mechanism 4 is used for filtering the antibodies in the filtering box 2. Both the cleaning mechanism 6 and the backwashing mechanism 7 are fixedly installed on the driving mechanism 5. The cleaning mechanism 6 is used for cleaning the filtering mechanism 4. By means of the cleaning mechanism 6, large particle impurities on the filter membrane 49 can be removed and discharged from the filtering box 2 through the discharge hopper 69. The backwashing mechanism 7 is used for backwashing the filtering mechanism 4, so that the impurities blocked in the pores of the filter membrane 49 can be removed, the cleaning effect on the filter membrane 49 can be improved, and the impurities are discharged from the filtering box 2 through the drainage hopper 713. The driving mechanism 5 is slidably installed on the filtering box 2, and the driving mechanism 5 is used for driving the cleaning mechanism 6 and the backwashing mechanism 7 to move simultaneously, so that the filter membrane 49 can be cleaned during the process of adjusting the position of the filter membrane 49.

[0023] Referring to Figures 2 to 4 , the filtering mechanism 4 includes a bearing plate 43, a mounting frame 44, a synchronous belt 45, a cylindrical rod 46, a synchronous pulley 47 and a filter membrane 49. The bearing plate 43 is fixedly installed on the filtering box 2. The bearing plate 43 is used for supporting the filtering mechanism 4 and bearing the antibodies. The mounting frame 44 is fixedly installed on the filtering box 2. The mounting frame 44 is used for protecting the synchronous belt 45. The synchronous pulley 47 is fixedly installed on the cylindrical rod 46, and the cylindrical rod 46 penetrates through the mounting frame 44 and the bearing plate 43. Through the rotation effect of the cylindrical rod 46, the synchronous pulley 47 can be driven to rotate. The filter membrane 49 is fixedly installed on the synchronous belt 45, and the synchronous belt 45 is slidably connected with the mounting frame 44. The filter membrane 49 is used for filtering the antibodies. Through the sliding effect of the synchronous belt 45, the filter membrane 49 can be driven to move to adjust the position of the filter membrane 49. The synchronous belt 45 meshes with the synchronous pulley 47. Through the rotation effect of the synchronous pulley 47, the synchronous belt 45 can be driven to move.

[0024] Referring to Figure 2, the filtering mechanism 4 further includes a hydraulic cylinder 41, a hydraulic plate 42 and a liquid discharge hopper 48. The hydraulic cylinder 41 is fixedly installed on the filtering box 2. By starting the hydraulic cylinder 41, the hydraulic plate 42 can be driven to move. The hydraulic plate 42 is fixedly installed on the output end of the hydraulic cylinder 41, and the hydraulic plate 42 is slidably connected to the bearing plate 43. Through the movement effect of the hydraulic plate 42, the antibody can be pushed to apply pressure to the filter membrane 49, improving the filtering efficiency of the antibody. The liquid discharge hopper 48 is fixedly installed on the filtering box 2. The liquid discharge hopper 48 is used to receive the filtered antibody and can discharge the filtered antibody from the filtering box 2. The cylindrical rod 46 is rotatably connected to the filtering box 2. The cylindrical rod 46 is fixedly installed on the driving mechanism 5. The driving mechanism 5 is used to drive the cylindrical rod 46 to rotate.

[0025] Refer to Figure 2 and Figure 6 , the driving mechanism 5 includes a bidirectional telescopic rod 51 and a connecting rod 52. The bidirectional telescopic rod 51 is rotatably installed on the filtering box 2 through a hinge block 53. By controlling the contraction of the hydraulic cylinder 41, the hydraulic plate 42 can be driven to squeeze the bidirectional telescopic rod 51, driving the bidirectional telescopic rod 51 to rotate. And the hinge block 53 is connected to the filtering box 2 through a torsion spring 511. Through the elastic force of the torsion spring 511, the bidirectional telescopic rod 51 always rotates in the direction extending towards the hydraulic cylinder 41 when not under external force. The connecting rod 52 is fixedly installed on the bidirectional telescopic rod 51. Through the rotation effect of the bidirectional telescopic rod 51, the connecting rod 52 can be driven to move. A sliding groove 54 is formed on the filtering box 2. The bidirectional telescopic rod 51 is slidably connected to the sliding groove 54 through a sliding column 510. The sliding groove 54 guides the sliding column 510, so that the connecting rod 52 does not deviate when moving.

[0026] Refer to Figures 3 to 6 , the driving mechanism 5 further includes a rack 56, a gear 57, a mounting rod 59, a mounting column 512 and a unidirectional limiting mechanism 58. The mounting rod 59 is hinged to the connecting rod 52 through a moving rod 55, and the moving rod 55 penetrates through the bearing plate 43. Through the movement effect of the connecting rod 52, the moving rod 55 can be driven to move, thereby driving the mounting rod 59 to move. The rack 56 is fixedly installed on the mounting rod 59, and the rack 56 is slidably connected to the filtering box 2. Through the movement effect of the mounting rod 59, the rack 56 can be driven to move. The mounting column 512 is fixedly installed on the cylindrical rod 46. The gear 57 is rotatably installed on the mounting column 512, and the gear 57 meshes with the rack 56. Through the movement effect of the rack 56, the gear 57 can be driven to rotate. The unidirectional limiting mechanism 58 is fixedly installed on the filtering box 2. The unidirectional limiting mechanism 58 is used to limit the cylindrical rod 46 in one direction, so that the cylindrical rod 46 can only rotate in one direction.

[0027] Refer to Figure 3 and Figure 7, the one-way limiting mechanism 58 includes a fixed ring 581 and two wedge blocks 584. The fixed ring 581 is fixedly installed on the filter box 2, and the fixed ring 581 is rotatably connected to the mounting column 512. Through the fixing effect of the fixed ring 581, the fixed ring 581 is prevented from falling off. A second slot 583 is formed on the fixed ring 581, and a first slot 582 is formed on the gear 57. The two wedge blocks 584 are respectively connected to the mounting column 512 through two springs 585, and the two wedge blocks 584 are both slidably connected to the mounting column 512. One side of the wedge block 584 is a straight surface, and the other side is an arc surface. Through the elastic force of the two springs 585, the two wedge blocks 584 are always kept respectively engaged with the first slot 582 and the second slot 583 without external force. The two wedge blocks 584 are respectively engaged with the first slot 582 and the second slot 583. When the gear 57 rotates clockwise, the first slot 582 will apply pressure to the straight surface of one wedge block 584 to drive the mounting column 512 and the cylindrical rod 46 to rotate. At the same time, the second slot 583 applies pressure to the arc surface of the other wedge block 584, causing the other wedge block 584 to contract. When the gear 57 rotates counterclockwise, the first slot 582 will apply pressure to the arc surface of one wedge block 584, causing one wedge block 584 to contract. At the same time, the second slot 583 applies pressure to the straight surface of the other wedge block 584, keeping the mounting column 512 and the cylindrical rod 46 fixed, realizing the one-way limiting function of the cylindrical rod 46. And when the rack 56 moves to the farthest distance, the two wedge blocks 584 will be respectively engaged with the first slot 582 and the second slot 583 at the same time.

[0028] Refer to Figure 5 and Figure 8 , the cleaning mechanism 6 includes a hinge plate 61, a scraper 62, a fixed block 63 and a T-shaped rod 65. The hinge plate 61 is hingedly installed on the bearing plate 43. The hinge plate 61 is used to receive large particle impurities falling on the filter membrane 49. The scraper 62 is fixedly installed on the bearing plate 43. Through the provided scraper 62, when the filter membrane 49 moves, the scraper 62 can scrape the impurities on the filter membrane 49. The fixed block 63 is fixedly installed on the bearing plate 43, and a guide groove 64 is formed on the fixed block 63. Through the provided guide groove 64, the T-shaped rod 65 is guided, and the T-shaped rod 65 can be slidably installed on the guide groove 64.

[0029] Refer to Figure 8, the cleaning mechanism 6 further includes an L-shaped rod 66, a first fixing plate 67, and a discharge hopper 69. The first fixing plate 67 is fixedly installed on the rack 56, and a first inclined groove 68 is formed on the first fixing plate 67. Through the movement effect of the rack 56, the first fixing plate 67 can be driven to move, so that the first inclined groove 68 drives the L-shaped rod 66 to move vertically. The L-shaped rod 66 is fixedly installed on the T-shaped rod 65, and the L-shaped rod 66 is slidably connected to the first inclined groove 68. Through the sliding effect of the L-shaped rod 66 along the first inclined groove 68, the L-shaped rod 66 moves vertically, thereby driving the T-shaped rod 65 to move vertically and slide along the guide groove 64, driving the hinge plate 61 to rotate and tilt. The discharge hopper 69 is fixedly installed on the filter box 2. When the hinge plate 61 rotates and tilts, the impurities on the hinge plate 61 can slide into the discharge hopper 69 for collection, which is convenient for subsequent processing. The L-shaped rod 66 penetrates through the discharge hopper 69.

[0030] Refer to Figure 2 and Figure 9 , the backwashing mechanism 7 includes a water tank 71, a box body 73, a water spray head 74, a water pump 75, and a water inlet pipe 78. The water tank 71 is fixedly installed on the filter box 2, and clear water is stored in the water tank 71 for backwashing the filter membrane 49. The box body 73 is fixedly installed on the bearing plate 43, and the box body 73 is used for temporarily storing the clear water conveyed by the water tank 71. The water inlet pipe 78 is fixedly installed on the box body 73, and the water inlet pipe 78 is communicated with the water tank 71 through a delivery pipe 72. Through the delivery pipe 72 and the water inlet pipe 78, the water in the water tank 71 can be conveyed into the box body 73. The water pump 75 is fixedly installed on the box body 73, and the water spray head 74 is fixedly installed on the box body 73. The water spray head 74 is used for spraying the water in the box body 73 onto the reverse side of the filter membrane 49, thereby backwashing the filter membrane 49. The input end of the water pump 75 is communicated with the box body 73 through a suction pipe 76, and the output end of the water pump 75 is communicated with the water spray head 74 through a drain pipe 77. By starting the water pump 75, the water in the box body 73 can be pumped into the water spray head 74 to backwash the filter membrane 49.

[0031] Refer to Figure 9 and Figure 10, the backwashing mechanism 7 further includes a second fixing plate 79, an L-shaped rod 711, a rubber plug 712 and a drain hopper 713. The second fixing plate 79 is fixedly installed on the rack 56. Through the movement effect of the rack 56, the second fixing plate 79 can be driven to move. An inclined slot 710 is formed on the second fixing plate 79. Through the movement effect of the second fixing plate 79, the inclined slot 710 can drive the L-shaped rod 711 to move vertically. The rubber plug 712 is fixedly installed on the L-shaped rod 711, and the rubber plug 712 is inserted into the water inlet pipe 78. Through the movement effect of the L-shaped rod 711, the rubber plug 712 can be driven to be inserted into the water inlet pipe 78, so that the water inlet pipe 78 is opened or closed. The L-shaped rod 711 can be slidably installed on the inclined slot 710, and the L-shaped rod 711 penetrates through the bearing plate 43 and the box body 73. The drain hopper 713 is fixedly installed on the filter box 2. The provided drain hopper 713 is used to receive the water carrying impurities after backwashing the filter membrane 49.

[0032] For the antibody screening and filtering device, through the provided filtering mechanism and driving mechanism, the antibody can be filtered. After the filtering is completed, the position of the filter membrane can be adjusted, so that the subsequent antibody can be filtered on the clean filter membrane surface, thereby improving the use effect and working efficiency of the antibody screening and filtering device. In addition, through the provided cleaning mechanism and backwashing mechanism, during the process of adjusting the position of the filter membrane, the filter membrane can be cleaned and backwashed, so as to separate and remove large-particle impurities and small-particle impurities on the filter membrane, so as to reuse the filter membrane, avoid clogging of the filter holes of the filter membrane, thereby improving the service life of the filter membrane and the use effect of the screening and filtering device. At the same time, through the cleaning mechanism, the large-particle impurities on the filter membrane can be cleaned first, avoiding friction between the filter membrane and the large-particle impurities during the process of moving and adjusting the position of the filter membrane, resulting in damage to the filter membrane and reducing the filtering performance of the filter membrane, and further improving the service life of the filter membrane and the use effect of the screening and filtering device.

[0033] The above is only the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and deformations can still be made, and these improvements and deformations should also be regarded as the protection scope of the present invention.

Claims

1. An antibody screening filtration device, characterized in that, It includes a base (1), a filtration box (2), a feed inlet (3), a filtration mechanism (4), a driving mechanism (5), a cleaning mechanism (6) and a backwashing mechanism (7). The filtration box (2) is fixedly installed on the base (1), the feed inlet (3) is fixedly installed on the filtration box (2), the filtration mechanism (4) is fixedly installed on the filtration box (2), and the filtration mechanism (4) is used to filter the antibody in the filtration box (2). Both the cleaning mechanism (6) and the backwashing mechanism (7) are fixedly installed on the driving mechanism (5). The cleaning mechanism (6) is used to clean the filtration mechanism (4), and the backwashing mechanism (7) is used to backwash the filtration mechanism (4). The driving mechanism (5) is slidably installed on the filtration box (2), and the driving mechanism (5) is used to drive the cleaning mechanism (6) and the backwashing mechanism (7) to move simultaneously.

2. The antibody screening and filtering device according to claim 1, wherein, The filtration mechanism (4) includes a bearing plate (43), a mounting frame (44), a synchronous belt (45), a cylindrical rod (46), a synchronous pulley (47) and a filter membrane (49). The bearing plate (43) is fixedly installed on the filtration box (2), the mounting frame (44) is fixedly installed on the filtration box (2), the synchronous pulley (47) is fixedly installed on the cylindrical rod (46), and the cylindrical rod (46) passes through the mounting frame (44) and the bearing plate (43). The filter membrane (49) is fixedly installed on the synchronous belt (45), and the synchronous belt (45) is slidably connected to the mounting frame (44). The synchronous belt (45) meshes with the synchronous pulley (47).

3. The antibody screening and filtering device according to claim 2, wherein The filtration mechanism (4) further includes a hydraulic cylinder (41), a hydraulic plate (42) and a liquid discharge hopper (48). The hydraulic cylinder (41) is fixedly installed on the filtration box (2), the hydraulic plate (42) is fixedly installed on the output end of the hydraulic cylinder (41), and the hydraulic plate (42) is slidably connected to the bearing plate (43). The liquid discharge hopper (48) is fixedly installed on the filtration box (2). The cylindrical rod (46) is rotatably connected to the filtration box (2), and the cylindrical rod (46) is fixedly installed on the driving mechanism (5). The driving mechanism (5) is used to drive the cylindrical rod (46) to rotate.

4. The antibody screening and filtering device according to claim 3, wherein, The driving mechanism (5) includes a bidirectional telescopic rod (51) and a connecting rod (52). The bidirectional telescopic rod (51) is rotatably installed on the filtration box (2) through a hinge block (53), and the hinge block (53) is connected to the filtration box (2) through a torsion spring (511). The connecting rod (52) is fixedly installed on the bidirectional telescopic rod (51). A chute (54) is provided on the filtration box (2), and the bidirectional telescopic rod (51) is slidably connected to the chute (54) through a sliding column (510).

5. The antibody screening and filtering device according to claim 4, wherein, The driving mechanism (5) further includes a rack (56), a gear (57), a mounting rod (59), a mounting column (512) and a one-way limiting mechanism (58). The mounting rod (59) is hinged to the connecting rod (52) through a moving rod (55), and the moving rod (55) penetrates through the bearing plate (43). The rack (56) is fixedly installed on the mounting rod (59), and the rack (56) is slidably connected to the filter box (2). The mounting column (512) is fixedly installed on the cylindrical rod (46). The gear (57) is rotatably installed on the mounting column (512), and the gear (57) meshes with the rack (56). The one-way limiting mechanism (58) is fixedly installed on the filter box (2), and the one-way limiting mechanism (58) is used to limit the cylindrical rod (46) in one direction.

6. The antibody screening and filtering device according to claim 5, characterized in that, The one-way limiting mechanism (58) includes a fixed ring (581) and two wedge blocks (584). The fixed ring (581) is fixedly installed on the filter box (2), and the fixed ring (581) is rotatably connected to the mounting column (512). A second card slot (583) is formed on the fixed ring (581). A first card slot (582) is formed on the gear (57). The two wedge blocks (584) are respectively connected to the mounting column (512) through two springs (585), and the two wedge blocks (584) are both slidably connected to the mounting column (512). The two wedge blocks (584) are respectively clamped with the first card slot (582) and the second card slot (583).

7. A kind of antibody screening and filtering device according to claim 1, characterized in that, The cleaning mechanism (6) includes a hinge plate (61), a scraper (62), a fixed block (63) and a T-shaped rod (65). The hinge plate (61) is hingedly installed on the bearing plate (43). The scraper (62) is fixedly installed on the bearing plate (43). The fixed block (63) is fixedly installed on the bearing plate (43), and a guide groove (64) is formed on the fixed block (63). The T-shaped rod (65) is slidably installed on the guide groove (64).

8. A kind of antibody screening and filtering device according to claim 7, characterized in that, The cleaning mechanism (6) further includes an L-shaped rod one (66), a fixing plate one (67) and a discharge hopper (69). The fixing plate one (67) is fixedly installed on the rack (56), and an inclined slot one (68) is formed on the fixing plate one (67). The L-shaped rod one (66) is fixedly installed on the T-shaped rod (65), and the L-shaped rod one (66) is slidably connected to the inclined slot one (68). The discharge hopper (69) is fixedly installed on the filter box (2), and the L-shaped rod one (66) penetrates through the discharge hopper (69).

9. The antibody screening and filtering device according to claim 1, wherein, The backwashing mechanism (7) includes a water tank (71), a box body (73), a water spray head (74), a water pump (75) and a water inlet pipe (78). The water tank (71) is fixedly installed on the filter box (2). The box body (73) is fixedly installed on the bearing plate (43). The water inlet pipe (78) is fixedly installed on the box body (73). The water inlet pipe (78) is communicated with the water tank (71) through a delivery pipe (72). The water pump (75) is fixedly installed on the box body (73). The water spray head (74) is fixedly installed on the box body (73). The input end of the water pump (75) is communicated with the box body (73) through a water suction pipe (76), and the output end of the water pump (75) is communicated with the water spray head (74) through a drain pipe (77).

10. A kind of antibody screening and filtering device according to claim 9, characterized in that, The backwashing mechanism (7) further includes a second fixing plate (79), an L-shaped rod second (711), a rubber plug (712) and a drain hopper (713). The second fixing plate (79) is fixedly installed on the rack (56). An inclined slot second (710) is formed in the second fixing plate (79). The rubber plug (712) is fixedly installed on the L-shaped rod second (711), and the rubber plug (712) is inserted into the water inlet pipe (78). The L-shaped rod second (711) is slidably installed in the inclined slot second (710), and the L-shaped rod second (711) penetrates through the bearing plate (43) and the box body (73). The drain hopper (713) is fixedly installed on the filter box (2).

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