Renewable and recyclable tourniquet and preparation method thereof

Abstract

The invention relates to a renewable and recyclable tourniquet and a preparation method thereof, and belongs to the technical field of tourniquet preparation. The tourniquet comprises the following raw materials in parts by weight: 70-95 parts of PBAT, 15-35 parts of a bio-based flexibilizer, 10-20 parts of polyethylene, 5-10 parts of a modified inorganic filler, 1-3 parts of an antioxidant and 1-3 parts of a lubricant. The bio-based toughening agent is prepared from bio-based dibasic acid and bio-based trihydric alcohol through a hyperbranched reaction. By introducing the bio-based toughening base, the polyethylene and the modified inorganic filler, the toughness of PBAT as a base material is improved jointly, the elastic property of the obtained composite material is improved, and the obtained tourniquet meets the use requirement during hemostasis.

Description

Technical Field

[0001] The present invention belongs to the technical field of tourniquet preparation, and specifically relates to a renewable and recyclable tourniquet and a preparation method thereof. Background Art

[0002] The tourniquet is made of medical polymer materials, is long and flat, and has strong stretchability. It is suitable for one-time use in medical institutions during routine treatment and rescue for infusion, blood drawing, blood transfusion, and hemostasis; or for emergency hemostasis in case of limb bleeding or bleeding from snake and insect bites in the wild.

[0003] The common tourniquet in the existing market is a rubber tourniquet. With the abandonment of the rubber tourniquet, it becomes medical waste rubber, and rubber is difficult to degrade, ultimately causing problems in the treatment of medical waste rubber. Therefore, how to make a renewable and recyclable tourniquet and a preparation method thereof can solve the problem of difficult treatment of current waste tourniquets. Summary of the Invention

[0004] In view of the above problems, the purpose of the present invention is to provide a renewable and recyclable tourniquet and a preparation method thereof.

[0005] The first object of the present invention can be achieved by the following technical solutions:

[0006] A renewable and recyclable tourniquet, comprising the following raw materials in parts by weight: 70 - 95 parts of PBAT (PBAT is the English abbreviation of Poly(butylene adipate - co - terephthalate)), 15 - 35 parts of bio - based toughening agent, 10 - 20 parts of polyethylene, 5 - 10 parts of modified inorganic filler, 1 - 3 parts of antioxidant, and 1 - 3 parts of lubricant;

[0007] The bio - based toughening agent is prepared by a hyper - branched reaction of a bio - based dibasic acid and a bio - based trihydric alcohol.

[0008] Further, the bio - based dibasic acid is obtained by a hydrosilylation reaction of 10 - undecenoic acid and dihydrogen - terminated siloxane in a molar ratio of 2 - 3:1.

[0009] The present invention uses a bio - based dibasic acid and a bio - based trihydric alcohol as reaction substrates, and through a hyper - branched reaction, a hyper - branched polyester is obtained. This hyper - branched polyester contains long alkyl chains (derived from castor oil derivative 10 - undecenoic acid), siloxane chains, phenyl groups, and ester groups, and uses long alkyl chains and siloxane chains as end - capped chains. Therefore, it can be used as a toughening agent.

[0010] Further, the dihydrogen - terminated siloxane is one or a mixture of any ratio of 1,1,3,3,5,5 - hexamethyltrisiloxane and 1,1,5,5 - tetramethyl - 3,3 - diphenyltrisiloxane.

[0011] Furthermore, the hydrosilylation reaction is carried out in a first solvent and in the presence of a first catalyst; the reaction temperature of the hydrosilylation reaction is 90 - 100 °C, and the reaction time is 4 - 12 h.

[0012] Furthermore, the first solvent is one of tetrahydrofuran, chloroform, benzene, and toluene; the first catalyst is one of platinum-based catalysts.

[0013] Furthermore, the bio-based triol is one of resveratrol and dihydroresveratrol or a mixture of the two in any ratio.

[0014] The molecular structural formula of resveratrol is as follows.

[0015]

[0016] The molecular structural formula of dihydroresveratrol is as follows.

[0017]

[0018] Furthermore, the molar ratio of the bio-based dibasic acid to the bio-based triol is 3.5 - 4:2.

[0019] Furthermore, the hyperbranched reaction is carried out in a second solvent and in the presence of a second catalyst; the reaction temperature of the hyperbranched reaction is 90 - 130 °C, and the reaction time is 6 - 12 h.

[0020] Furthermore, the second solvent is one of chloroform, carbon tetrachloride, toluene, n-hexane, and cyclohexane; the second catalyst is one of concentrated sulfuric acid and p-toluenesulfonic acid.

[0021] Furthermore, the modified inorganic filler is an inorganic filler modified with a silane coupling agent. The method of modifying the inorganic filler with a silane coupling agent is common knowledge in the technical field, and thus, it will not be elaborated herein. The silane coupling agent is one of the silane coupling agents well-known in the technical field.

[0022] Furthermore, the inorganic filler is one of nano-silica and calcium carbonate whiskers.

[0023] The oxidant and the lubricant are the oxidant and the lubricant well-known in the technical field, and no special limitation is imposed in the present invention.

[0024] Furthermore, the second object of the present invention can be achieved by the following technical solution:

[0025] A preparation method of a renewable and recyclable tourniquet, comprising:

[0026] After premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant and lubricant, melt extrusion, granulation and molding are carried out to obtain a tourniquet.

[0027] Furthermore, the melt extrusion temperature is 190 - 240 °C.

[0028] Advantages of the present invention:

[0029] The renewable and recyclable tourniquet provided by the present invention and its preparation method use PBAT as the base material, introduce polyethylene and modified inorganic filler as elastic reinforcing fillers, and introduce a bio-based toughening base to improve the blending performance of polyethylene and modified inorganic filler with PBAT, especially improve the compatibility of polyethylene and PBAT, so as to enable the melt processing performance of their blend;

[0030] By introducing a bio-based toughening base, polyethylene and modified inorganic filler, the toughness of the PBAT-based material is improved by the three together, and the elastic properties of the obtained composite material are improved, so that the obtained tourniquet meets the use requirements during hemostasis. Moreover, the bio-based toughening agent is made based on the hyperbranched reaction (esterification reaction) of bio-based dibasic acid and bio-based triol, and both it and PBAT can recover the corresponding acid monomers and alcohol monomers through the decomposition reaction of esters. The corresponding acid monomers and alcohol monomers can be recovered, and during the decomposition reaction of esters of the bio-based toughening agent and PBAT, the polyethylene and inorganic filler therein can also be recovered. It can be seen that the tourniquet of the present invention can be recycled. Detailed implementation manners

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0032] Example 1

[0033] Preparation of bio-based toughening agent:

[0034] A1. After uniformly mixing 0.22 mol of 10-undecenoic acid, 0.2 mol of 1,1,5,5-tetramethyl-3,3-diphenyltrisiloxane and 100 mL of benzene, 10 g of platinum catalyst (platinum supported on carbon) is added, heated to 90 °C, and the stirring reaction time is 12 h. Rotary evaporation, washing and drying are carried out to obtain a bio-based dibasic acid;

[0035] A2. After uniformly mixing 0.35 mol of bio-based dibasic acid, 0.2 mol of resveratrol, 4 g of p-toluenesulfonic acid, and 150 mL of carbon tetrachloride, heat to 100 °C, stir for a reaction time of 12 h, perform rotary evaporation, washing, and drying to obtain a bio-based toughening agent.

[0036] Example 2

[0037] Preparation of bio-based toughening agent:

[0038] A1. After uniformly mixing 0.3 mol of 10-undecenoic acid, 0.2 mol of 1,1,3,3,5,5-hexamethyltrisiloxane, and 100 mL of toluene, add 13 g of a platinum catalyst (platinum supported on carbon), heat to 100 °C, stir for a reaction time of 4 h, perform rotary evaporation, washing, and drying to obtain a bio-based dibasic acid;

[0039] A2. After uniformly mixing 0.4 mol of bio-based dibasic acid, 0.2 mol of dihydroresveratrol, 5 g of p-toluenesulfonic acid, and 150 mL of n-hexane, heat to 130 °C, stir for a reaction time of 6 h, perform rotary evaporation, washing, and drying to obtain a bio-based toughening agent.

[0040] Example 3

[0041] Preparation of tourniquet:

[0042] First step. Prepare raw materials including the following parts by weight: 95 parts of PBAT, 15 parts of the bio-based toughening agent prepared in Example 2, 20 parts of polyethylene, 10 parts of a modified inorganic filler (nano-silica modified with KH570), 3 parts of an antioxidant (antioxidant 1010), and 3 parts of a lubricant (polyethylene wax)

[0043] Second step. After premixing PBAT, the bio-based toughening agent, polyethylene, the modified inorganic filler, the antioxidant, and the lubricant, perform melt extrusion, granulation, and molding to obtain a tourniquet; the melt extrusion temperature is 190 - 240 °C.

[0044] Example 4

[0045] Preparation of tourniquet:

[0046] First step. Prepare raw materials including the following parts by weight: 85 parts of PBAT, 25 parts of the bio-based toughening agent prepared in Example 2, 15 parts of polyethylene, 7 parts of a modified inorganic filler (nano-silica modified with KH570), 2 parts of an antioxidant (antioxidant 1010), and 2 parts of a lubricant (polyethylene wax);

[0047] Second step. After premixing PBAT, the bio-based toughening agent, polyethylene, the modified inorganic filler, the antioxidant, and the lubricant, perform melt extrusion, granulation, and molding to obtain a tourniquet; the melt extrusion temperature is 190 - 240 °C.

[0048] Example 5

[0049] Preparation of tourniquet:

[0050] First step: Prepare raw materials including the following parts by weight: 70 parts of PBAT, 35 parts of the bio-based toughening agent prepared in Example 1, 10 parts of polyethylene, 5 parts of modified inorganic filler (nano-silica modified by KH570), 1 part of antioxidant (antioxidant 1010), and 1 part of lubricant (polyethylene wax);

[0051] Second step: After premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant and lubricant, melt extrusion, granulation and molding are carried out to obtain a tourniquet; the melt extrusion temperature is 190 - 240 °C.

[0052] Comparative Example 1

[0053] Preparation of tourniquet:

[0054] Compared with Example 3, the bio-based toughening agent in the raw materials is deleted, and the rest are the same.

[0055] Comparative Example 2

[0056] Preparation of tourniquet:

[0057] Compared with Example 3, the polyethylene in the raw materials is deleted, and the rest are the same.

[0058] Comparative Example 3

[0059] Preparation of tourniquet:

[0060] Compared with Example 3, the inorganic filler in the raw materials is deleted, and the rest are the same.

[0061] The pellets obtained in Examples 3 - 5 and Comparative Examples 1 - 3 are made into specimens for the following physical property tests, and the test results are shown in Table 1.

[0062] Table 1

[0063] Serial number Tensile strength Elongation at break Test standard GB / T 1040 GB / T 1040 Unit MPa ％ Example 3 23.1 328 Example 4 25.6 345 Example 5 16.8 362 Comparative example 1 16.3 184 Comparative example 2 20.7 236 Comparative example 3 22.2 268

[0064] From the data in Table 1, it can be seen that the pellets of the tourniquets obtained in Examples 3 - 5 have good elastic properties.

[0065] In the description of the specification, the descriptions referring to terms such as "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0066] The above content is only an illustration and description of the present invention. Those skilled in the art of the present technology can make various modifications or supplements to the described specific embodiments or use similar methods for substitution, as long as they do not deviate from the invention or exceed the scope defined by the claims of the present invention, they shall fall within the protection scope of the present invention.

Claims

1. A renewable and recyclable tourniquet, characterized in that, It comprises raw materials in the following parts by weight: 70-95 parts of PBAT, 15-35 parts of bio-based toughening agent, 10-20 parts of polyethylene, 5-10 parts of modified inorganic filler, 1-3 parts of antioxidant, and 1-3 parts of lubricant; The bio-based toughening agent is prepared by a hyperbranched reaction of a bio-based dibasic acid and a bio-based triol.

2. The renewable and recyclable tourniquet according to claim 1, characterized in that, The bio-based dibasic acid is obtained by a hydrosilylation reaction of 10-undecenoic acid and dihydrogen-terminated siloxane in a molar ratio of 2-3:

1.

3. The renewable and recyclable tourniquet according to claim 2, characterized in that, The dihydrogen-terminated siloxane is one or a mixture of any ratio of 1,1,3,3,5,5-hexamethyltrisiloxane and 1,1,5,5-tetramethyl-3,3-diphenyltrisiloxane.

4. The renewable and recyclable tourniquet according to claim 2, wherein, The hydrosilylation reaction is carried out in a first solvent and a first catalyst; the reaction temperature of the hydrosilylation reaction is 90-100 °C, and the reaction time is 4-12 h.

5. A renewable and recyclable tourniquet according to claim 4, characterized in that, The first solvent is one of tetrahydrofuran, chloroform, benzene, and toluene; the first catalyst is one of platinum-based catalysts.

6. The renewable and recyclable tourniquet according to claim 1, wherein The bio-based triol is one or a mixture of any ratio of resveratrol and dihydroresveratrol.

7. A renewable and recyclable tourniquet according to claim 1, characterized in that, The molar ratio of the bio-based dibasic acid to the bio-based triol is 3.5-4:

2.

8. A renewable and recyclable tourniquet according to claim 1, characterized in that, The hyperbranched reaction is carried out in a second solvent and a second catalyst; the reaction temperature of the hyperbranched reaction is 90-130 °C, and the reaction time is 6-12 h.

9. The renewable and recyclable tourniquet according to claim 8, wherein The second solvent is one of chloroform, carbon tetrachloride, toluene, n-hexane, and cyclohexane; the second catalyst is one of concentrated sulfuric acid and p-toluenesulfonic acid.

10. The preparation method of a renewable and recyclable tourniquet according to claim 1, characterized in that, It includes: After premixing PBAT, bio-based toughening agent, polyethylene, modified inorganic filler, antioxidant, and lubricant, melt extrusion, granulation, and molding are carried out to obtain a tourniquet.

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