Formula for treating lumbar spondylosis and processing method

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a formula for treating lumbar spondylosis, which comprises the following components in parts by weight: 15 parts of teasel, 5 parts of golden cypress, 20 parts of frankincense, 15 parts of myrrh, 20 parts of honeysuckle stem, 20 parts of suberect spatholobus stem, 30 parts of poria, 15 parts of safflower, 15 parts of Chinese angelica, 15 parts of rhizoma drynariae, 15 parts of rhizoma cibotii, 15 parts of cortex acanthopanacis, 15 parts of achyranthes root, 15 parts of earthworm, 10 parts of geranium wilfordii and 10 parts of endothelium corneum gigeriae galli. The compound compatibility principle of tonifying the liver and the kidney, promoting blood circulation to remove blood stasis and dredging collaterals and removing dampness is fused, through the synergistic effect of the radix dipsaci and the rhizoma drynariae for consolidating the root and strengthening tendons and the frankincense and the myrrh for removing blood stasis and relieving pain, the pathologic basis of deficiency in root and excess in excess of lumbar degenerative diseases is fundamentally improved, meanwhile, the compatibility of the cortex phellodendri for clearing heat and the poria for promoting diuresis is used for regulating and controlling the metabolic environment of an organism, and the curative effect is achieved. By combining the synergistic design that endothelium corneum gigeriae galli assists transportation and transformation and achyranthes bidentata introduces medicines, a multi-target intervention mechanism is formed, and the comprehensive curative effect of anti-inflammatory analgesia and tissue repair is remarkably enhanced.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and specifically relates to a formula for treating lumbar spondylosis and a processing method thereof. Background Art

[0002] Lumbar spondylosis is a general term for a common type of disease in spinal surgery, mainly involving structural lesions in parts such as the lumbar intervertebral disc, lumbar vertebrae, and paravertebral soft tissues. It is mostly caused by factors such as lumbar degenerative changes (such as water loss and decreased elasticity of the intervertebral disc), long-term bad postures (such as sitting for a long time, hunching the back), trauma, and overwork.

[0003] As a common degenerative osteoarticular disease, clinical treatment of lumbar spondylosis mostly uses traditional Chinese medicine compound decoctions to exert the advantages of multi-target regulation. In the prior art, traditional Chinese medicine for treating lumbar spondylosis mainly uses drugs for promoting blood circulation to remove blood stasis and dispelling wind and dampness, such as safflower, angelica, and achyranthes bidentata. It relieves symptoms by improving local microcirculation and inhibiting inflammatory reactions. However, there are still some deficiencies. First, the existing prescriptions mostly focus on dispelling pathogenic factors and dredging collaterals, but ignore the core pathogenesis of liver and kidney deficiency in lumbar spondylosis, lacking systematic compatibility of drugs for tonifying the liver and kidney and strengthening tendons and bones, such as dipsacus asperoides, drynaria rhizome, and cibotium barometz, resulting in difficult treatment of the root cause and easy recurrence of patients. Second, the synergistic mechanism of medicinal materials is single, and the auxiliary synergistic designs such as using endothelium corneum gigeriae galli to promote digestion and absorption and using phellodendron amurense and poria cocos to regulate the internal environment of dampness and heat are not fully utilized, resulting in a single level of drug efficacy and difficulty in taking into account the composite requirements of inflammation control, metabolic regulation, and tissue repair. Third, the traditional decocting method lacks refined temperature control and staged drug addition strategies. Resinous medicinal materials are prone to gelatinization and caking due to direct high-temperature decoction, resulting in low dissolution rate of active ingredients, and there are more residues of tannins and suspended substances during the concentration process of the medicinal liquid, with a bitter taste and possible gastrointestinal irritation, which needs to be improved. Summary of the Invention

[0004] Aiming at the deficiencies of the prior art, the present invention provides a formula for treating lumbar spondylosis and a processing method thereof, which have the advantages of multi-target synergistic treatment.

[0005] To achieve the above object, the present invention provides the following technical solution: A formula for treating lumbar spondylosis, the formula includes the following components in parts by weight: 15 parts of dipsacus asperoides, 5 parts of phellodendron amurense, 20 parts of frankincense, 15 parts of myrrh, 20 parts of honeysuckle stem, 20 parts of millettia reticulata, 30 parts of poria cocos, 15 parts of safflower, 15 parts of angelica, 15 parts of drynaria rhizome, 15 parts of cibotium barometz, 15 parts of acanthopanax gracilistylus, 15 parts of achyranthes bidentata, 15 parts of pheretima, 10 parts of geranium wilfordii, and 10 parts of endothelium corneum gigeriae galli.

[0006] Preferably, the cibotium barometz should be stir-fried with sand in a standardized manner, and it is necessary to avoid using the raw product without removing the burrs.

[0007] Preferably, the frankincense should be stir-fried with vinegar, with a dark yellow surface and a crispy texture. It is necessary to avoid using raw frankincense without processing or products with excessive impurities.

[0008] A processing method for a treatment formula for lumbar spondylosis includes the following steps:

[0009] Step 1: Pretreatment of medicinal materials

[0010] Place Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb., Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii in a bamboo sieve and quickly rinse them with running water to remove surface dust and foreign objects; place Pheretima aspergillum in a stainless steel strainer and repeatedly rinse it 5 - 6 times with a high-pressure water gun at a pressure of 0.3 MPa until the rinsing water is clear and there is no sediment deposition; put frankincense and myrrh into a double-layer fine cotton bag (120 mesh) and gently knock them into small pieces the size of soybeans with a wooden mallet to prevent resin powder leakage; for Drynaria fortunei, use a spatula to scrape off the surface brown villi longitudinally and cut it into slices 2 mm thick for later use; crush Poria cocos into irregular particles 3 - 5 mm in size with a medicinal material grinder to increase the contact area for decoction;

[0011] Step 2: First decoction of medicinal materials

[0012] Pour 2000 ml of pure water into a ceramic medicine pot, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the pure water to the boiling state of 100 °C. In the continuous boiling state, successively put in Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb., Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii. Then immediately use a long-handled spoon to stir clockwise at a constant speed for 30 seconds to evenly moisten the medicinal materials. Then adjust the heating power to maintain the water temperature at 85 ± 2 °C. At this time, vertically suspend the pre-treated cotton bags of frankincense and myrrh in the ceramic medicine pot; start the timer for a 90-minute main decoction process after the medicinal materials are put in. During this period, every 15 minutes, use a bamboo stirring rod to slowly push and press the medicinal materials along the inner wall of the medicine pot and stir clockwise for 12 circles to promote the dissolution of active ingredients; when the volume of the medicinal liquid is concentrated by evaporation to 800 ml, immediately turn off the heating furnace and conduct primary filtration with a 300-mesh filter cloth, and collect the first medicinal liquid into a sterilized glass container;

[0013] Step 3: Second decoction

[0014] Put the medicinal residues back into the ceramic medicine pot, add 1500 ml of pure water, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the water temperature to the boiling state of 100 °C, and then adjust the temperature to 85 °C to maintain a slightly boiling state. When the medicinal liquid is concentrated to 500 ml, conduct secondary filtration with a 300-mesh filter cloth to obtain 500 ml of secondary medicinal liquid, and then pour the secondary medicinal liquid into the glass container storing the first medicinal liquid to obtain 1300 ml of decocted medicinal liquid;

[0015] Step 4: Refinement and concentration of the medicinal liquid

[0016] Transfer the mixed 1300 ml of decocted medicinal liquid to the concentration pot, use a constant temperature water bath to maintain a low-temperature concentration environment, and at the same time use a glass rod to dip the medicinal liquid to observe the wall-hanging effect. When the volume is concentrated to 1 / 3 of the original volume, immediately stop heating. After concentration, filter through a 0.22 μm microporous filter membrane to remove tannins and fine suspended matters;

[0017] Step Five: Sub-packaging, sterilization and storage

[0018] Let the concentrated medicinal liquid stand until the temperature is below 45°C, transfer it to a sterile filling device for sub-packaging, and sub-package it into high-temperature-resistant medical aluminum foil bags according to the single-dose (150 ml / bag) to avoid oxidation; after packaging, place the medicinal liquid in a constant temperature water bath, and maintain it at 65°C for 30 minutes for low-temperature sterilization to retain the active ingredients and kill microorganisms at the same time.

[0019] Preferably, during the concentration process of the refined concentration of the medicinal liquid in Step Four, use a pH test paper to detect the acidity and alkalinity of the medicinal liquid every 20 minutes to ensure that it is maintained within the range of 5.5 - 6.0.

[0020] Preferably, for the constant temperature water bath heating in Step Four, the water bath maintains a low-temperature concentration environment of 60 - 65°C, and at the same time turn on the magnetic stirrer to stir at a constant speed of 30 revolutions per minute.

[0021] Preferably, when the cotton cloth bags of frankincense and myrrh are hung inside the ceramic medicine pot in Step Two, it is necessary to ensure that the cotton cloth bags are immersed in the liquid surface, and at the same time avoid the cotton cloth bags directly contacting the bottom of the pot.

[0022] Preferably, after the secondary medicinal liquid is poured into the glass container containing the primary medicinal liquid in Step Three, use a glass rod to stir to ensure the mixing of the medicinal liquid.

[0023] Preferably, for the medicinal material treatment in Step One, the yellow inner membrane residue of the chicken gizzard skin is removed manually, the folds are gently brushed with a soft brush, and finally rinsed with clean water.

[0024] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0025] Integrating the compound compatibility principles of tonifying the liver and kidney, promoting blood circulation to remove blood stasis, and dredging collaterals to dispel dampness, through the synergistic effects of Dipsacus asperoides and Drynaria fortunei for strengthening the muscles and bones, and Frankincense and Myrrh for removing stasis and alleviating pain, it improves the pathological basis of deficiency in origin and excess in superficiality of lumbar degenerative diseases from the root. At the same time, the compatibility of Phellodendron amurense for clearing heat and Poria cocos for promoting diuresis regulates the body's metabolic environment, combined with the synergistic design of Endothelium Corneum Gigeriae Galli for promoting digestion and Achyranthes bidentata for guiding the medicine to act, forming a multi-target intervention mechanism, significantly enhancing the comprehensive efficacy of anti-inflammatory analgesia and tissue repair; during the processing, refined processes such as controlling the temperature of resinous medicinal materials during different stages of decocting and concentrating at low temperature are adopted to maximize the retention of the biological activity of thermosensitive active ingredients, reduce the irritation of liquid medicine impurities to the gastrointestinal tract, and ensure the efficient dissolution and stable release of medicinal ingredients, ultimately achieving the application advantages of long-lasting efficacy, high safety, and wide indications. Detailed implementation mode

[0026] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0027] The embodiment of the present invention provides a formula for treating lumbar diseases, and the formula includes the following components in parts by weight: 15 parts of Dipsacus asperoides, 5 parts of Phellodendron amurense, 20 parts of Frankincense, 15 parts of Myrrh, 20 parts of Lonicera japonica Thunb. Stem, 20 parts of Spatholobus suberectus Dunn, 30 parts of Poria cocos, 15 parts of Carthamus tinctorius, 15 parts of Angelica sinensis, 15 parts of Drynaria fortunei, 15 parts of Cibotium barometz, 15 parts of Acanthopanax gracilistylus W. W. Smith, 15 parts of Achyranthes bidentata, 15 parts of Pheretima aspergillum, 10 parts of Geranium wilfordii Maxim., 10 parts of Endothelium Corneum Gigeriae Galli.

[0028] Through medicinal materials such as Dipsacus asperoides, Drynaria fortunei, Cibotium barometz, and Acanthopanax gracilistylus W. W. Smith tonifying the liver and kidney and strengthening the muscles and bones to enhance the supporting function of the lumbar spine, combined with Frankincense, Myrrh, Carthamus tinctorius, and Angelica sinensis promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain to relieve local inflammation and nerve compression, supplemented by Spatholobus suberectus Dunn, Lonicera japonica Thunb. Stem, Pheretima aspergillum, and Geranium wilfordii Maxim. dredging collaterals, expelling wind and removing dampness to improve blood circulation and the excretion of metabolic wastes, at the same time, Phellodendron amurense clearing heat and drying dampness, and Poria cocos strengthening the spleen and promoting diuresis can regulate the internal damp-heat environment, Achyranthes bidentata guiding the medicine downward to reach the lesion site, and Endothelium Corneum Gigeriae Galli promoting digestion and helping the absorption of medicine.

[0029] Among them, Cibotium barometz should be stir-fried with sand according to the standard processing method, and avoid using the raw product without removing the burrs.

[0030] If the raw product of Cibotium barometz is used, it must be stir-fried with sand to remove the burrs. Stir-fry the raw Cibotium barometz with hot sand until it swells, sieve out the burrs after they are carbonized before it can be used as medicine.

[0031] Among them, Frankincense must be selected as the vinegar-fried Frankincense, with a dark yellow surface and a crispy texture, and avoid using the raw Frankincense without processing or the product with excessive impurities.

[0032] If raw frankincense is used, it must be processed by the method of frying with vinegar. The raw frankincense pieces are evenly mixed with rice vinegar in a ratio of 10:1, and the iron pot is preheated to 120 °C and slightly fried until the surface is shiny and dark yellow. After the vinegar liquid is completely absorbed, it is dried, and the pungent volatile oil is removed before it can be used as medicine.

[0033] A processing method for a treatment formula for lumbar spondylosis includes the following steps:

[0034] Step 1: Pretreatment of medicinal materials

[0035] Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb., Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii are placed in a bamboo sieve and quickly rinsed with running water to remove surface dust and foreign matters; Earthworms are placed in a stainless-steel drain basin and repeatedly rinsed 5-6 times with a high-pressure water gun at a pressure of 0.3 MPa until the rinsing water is clear and there is no sediment deposition; Frankincense and myrrh are put into a double-layer fine cotton cloth bag (120 mesh) and gently knocked with a wooden mallet into pieces the size of soybeans to prevent the leakage of resin powder; Drynaria fortunei needs to be scraped longitudinally along the surface with a spatula to remove the brown villi and cut into slices 2 mm thick obliquely for later use; Poria cocos is crushed into irregular particles 3-5 mm in size by a medicinal material grinder to increase the contact area for decoction;

[0036] Step 2: First decoction of medicinal materials

[0037] Inject 2000 ml of pure water into a ceramic medicine pot, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the pure water to the boiling state of 100 °C. In the continuous boiling state, Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb., Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii are put in successively. Then immediately use a long-handled spoon to stir clockwise at a constant speed for 30 seconds to evenly moisten the medicinal materials, and then adjust the heating power to keep the water temperature at 85 ± 2 °C. At this time, the pre-treated cotton cloth bags of frankincense and myrrh are vertically suspended in the ceramic medicine pot; Start the 90-minute main decoction process by starting the timer after the medicinal materials are put in. During this period, every 15 minutes, use a bamboo stirring rod to slowly push and press the medicinal materials along the inner wall of the medicine pot and stir clockwise for 12 circles to promote the dissolution of active ingredients; When the volume of the medicinal liquid is concentrated to 800 ml by evaporation, immediately turn off the heating furnace and use a 300-mesh filter cloth for primary filtration, and collect the first medicinal liquid into a sterilized glass container;

[0038] Step 3: Second decoction

[0039] Put the medicinal residues back into the ceramic medicine pot, add 1500 ml of pure water, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the water temperature to the boiling state of 100 °C, and then adjust the temperature to 85 °C to maintain a slightly boiling state. When the medicinal liquid is concentrated to 500 ml, use a 300-mesh filter cloth for secondary filtration to obtain 500 ml of secondary medicinal liquid, and then pour the secondary medicinal liquid into the glass container storing the first medicinal liquid to obtain 1300 ml of decocted medicinal liquid;

[0040] Step 4: Refinement and Concentration of the Medicinal Liquid

[0041] Transfer the mixed 1300 ml of decocted medicinal liquid to a concentration pot, maintain a low-temperature concentration environment using a constant-temperature water bath, and at the same time use a glass rod to dip the medicinal liquid to observe the wall-hanging effect. Stop heating immediately when it is concentrated to 1 / 3 of the original volume. After concentration, filter through a 0.22 μm microporous filter membrane to remove tannins and fine suspended matter;

[0042] Step 5: Sub-packaging, Sterilization and Storage

[0043] Let the concentrated medicinal liquid stand until the temperature is below 45°C, transfer it to a sterile filling equipment for sub-packaging, and sub-package it into heat-resistant medicinal aluminum foil bags according to the single-dose (150 ml / bag) to avoid oxidation; after packaging, place the medicinal liquid in a constant-temperature water bath, and maintain it at 65°C for 30 minutes for low-temperature sterilization to retain the active ingredients and kill microorganisms at the same time.

[0044] Through the refined and meticulous pretreatment of the medicinal materials, combined with the two-time decoction process of the pottery medicine pot and the 60 - 65°C low-temperature magnetic stirring concentration technology, the thermosensitive active ingredients are effectively retained. Finally, through aseptic sub-packaging below 45°C and 65°C constant-temperature water bath low-temperature sterilization, a standardized processing system that takes into account the efficient extraction of ingredients, the deep removal of impurities and the stable preservation of drug efficacy is formed, comprehensively improving the safety and efficacy stability of the decoction.

[0045] Among them, during the concentration process of the refinement and concentration of the medicinal liquid in Step 4, use a pH test paper to detect the acidity and alkalinity of the medicinal liquid every 20 minutes to ensure that it is maintained within the range of 5.5 - 6.0.

[0046] By regularly monitoring the acidity and alkalinity of the medicinal liquid, the chemical structure of the active ingredients can be stabilized, preventing the excessive hydrolysis of alkaloid substances, ensuring that the ionic balance state of the medicinal liquid meets the requirements of human absorption, and improving the bioavailability of the drug.

[0047] Among them, in Step 4, for the constant-temperature water bath heating, the water bath maintains a low-temperature concentration environment of 60 - 65°C, and at the same time turn on the magnetic stirrer to stir at a constant speed of 30 revolutions per minute.

[0048] Through the low-temperature constant-speed stirring concentration process, the loss of volatile components can be reduced, the protein denaturation caused by high temperature can be avoided, and at the same time, the concentration gradient of the medicinal liquid is dynamically balanced, and the retention rate of macromolecular active substances is improved.

[0049] Among them, when the cotton cloth bags of frankincense and myrrh are hung inside the pottery medicine pot in Step 2, it is necessary to ensure that the cotton cloth bags are immersed in the liquid surface, and at the same time avoid the cotton cloth bags directly contacting the bottom of the pot.

[0050] The slow-release extraction of resinous medicinal materials is achieved through the hanging immersion method, preventing the destruction of terpene compounds by high-temperature coking, promoting the uniform diffusion of fat-soluble components by using the liquid surface tension, and improving the integrity of the extraction of the effective components of the resin.

[0051] Among them, after the secondary medicinal liquid is poured into the glass container containing the primary medicinal liquid in step three, a glass rod needs to be used for stirring to ensure the mixing of the medicinal liquids.

[0052] The concentration difference of the medicinal liquids in different decocting stages is eliminated through mechanical mixing, ensuring that the uniformity of the distribution of drug components within a batch meets the clinical standards.

[0053] Among them, in step one, for the Chinese medicinal material processing of chicken gizzard-membrane, the residual yellow inner membrane is removed by hand tearing, the folds are gently brushed with a soft brush, and finally it is rinsed with clean water.

[0054] By carefully processing the chicken gizzard-membrane, the cleanliness level of the medicinal material processing is improved.

[0055] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device.

[0056] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A formula for the treatment of lumbar spondylosis, characterized in that, The formula comprises the following components in parts by weight: 15 parts of Dipsacus asperoides, 5 parts of Phellodendron amurense, 20 parts of Olibanum, 15 parts of Myrrha, 20 parts of Lonicera japonica Thunb. stem, 20 parts of Spatholobus suberectus, 30 parts of Poria cocos, 15 parts of Carthamus tinctorius, 15 parts of Angelica sinensis, 15 parts of Drynaria fortunei, 15 parts of Cibotium barometz, 15 parts of Acanthopanax gracilistylus, 15 parts of Achyranthes bidentata, 15 parts of Pheretima aspergillum, 10 parts of Geranium wilfordii, 10 parts of Endothelium corneum gigeriae galli.

2. A formula for the treatment of lumbar spondylosis according to claim 1, characterized in that: The Cibotium barometz should be stir-fried with sand in a standardized manner, and it is necessary to avoid using the raw product without removing the burrs.

3. A formula for the treatment of lumbar spondylosis according to claim 1, characterized in that: The Olibanum must be the vinegar-processed Olibanum, with a dark yellow surface and a crispy texture. It is necessary to avoid using the raw Olibanum without processing or the product with excessive impurities.

4. A processing method for a treatment formula for lumbar spondylosis, characterized in that, It includes the following steps: Step 1: Pretreatment of medicinal materials Place Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb. stem, Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii in a bamboo sieve, and quickly rinse them with running water to remove the surface dust and foreign matters; place Pheretima aspergillum in a stainless steel colander, and repeatedly rinse it 5 - 6 times with a high-pressure water gun at a pressure of 0.3 MPa until the rinsing water is clear without sediment deposition; put Olibanum and Myrrha into a double-layer fine cotton cloth bag (120 mesh), and gently knock them into small pieces the size of soybeans with a wooden mallet to prevent the leakage of resin powder; use a scraper to scrape the surface brown villi of Drynaria fortunei longitudinally and cut it into slices 2 mm thick obliquely for standby; crush Poria cocos into irregular particles 3 - 5 mm in size through a medicinal material crusher to increase the contact area for decoction; Step 2: First decoction of medicinal materials Inject 2000 ml of pure water into a ceramic medicine pot, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the pure water to the boiling state of 100℃. Under the continuous boiling state, successively add Dipsacus asperoides, Phellodendron amurense, Lonicera japonica Thunb. stem, Spatholobus suberectus, Poria cocos, Carthamus tinctorius, Angelica sinensis, Drynaria fortunei, Cibotium barometz, Acanthopanax gracilistylus, Achyranthes bidentata, Geranium wilfordii, and then immediately use a long-handled spoon to stir clockwise at a constant speed for 30 seconds to evenly moisten the medicinal materials. Then adjust the heating power to maintain the water temperature at 85 ± 2℃. At this time, vertically suspend the pre-treated cotton cloth bag of Olibanum and Myrrha in the ceramic medicine pot; start the timer to begin the 90-minute main decoction process after the medicinal materials are put in. During this period, every 15 minutes, slowly push and press the medicinal materials along the inner wall of the medicine pot with a bamboo stirring rod and stir clockwise for 12 circles to promote the dissolution of active ingredients; when the volume of the medicinal liquid is concentrated to 800 ml by evaporation, immediately turn off the heating furnace, and use a 300-mesh filter cloth for primary filtration, and collect the first medicinal liquid into a sterilized glass container; Step 3: Second decoction Put the medicinal residues back into the ceramic medicine pot, add 1500 ml of pure water, and then use a heating furnace to heat the ceramic medicine pot to quickly raise the water temperature to the boiling state of 100℃, and then adjust the temperature to 85℃ to maintain a slightly boiling state. When the medicinal liquid is concentrated to 500 ml, use a 300-mesh filter cloth for secondary filtration to obtain 500 ml of the second medicinal liquid, and then pour the second medicinal liquid into the glass container storing the first medicinal liquid to obtain 1300 ml of the decocted medicinal liquid; Step 4: Refinement and concentration of the medicinal liquid Transfer the mixed 1300 ml of decocted medicinal liquid to the concentration pot, use a constant temperature water bath to maintain a low-temperature concentration environment, and at the same time use a glass rod to dip the medicinal liquid to observe the wall-hanging effect. When it is concentrated to 1 / 3 of the original volume, immediately stop heating. After concentration, filter through a 0.22 μm microporous filter membrane to remove tannins and fine suspended matter; Step Five: Sub-packaging, Sterilization and Storage Let the concentrated medicinal liquid stand until the temperature is below 45°C, transfer it to a sterile filling device for sub-packaging, and sub-package it into heat-resistant medicinal aluminum foil bags according to the single-dose (150 ml / bag) to avoid oxidation; after packaging, place the medicinal liquid in a constant temperature water bath, and maintain it at 65°C for 30 minutes for low-temperature sterilization to retain the active ingredients and kill microorganisms at the same time.

5. The processing method of a treatment formula for lumbar spondylosis according to claim 4, characterized in that: During the refining and concentration of the medicinal liquid described in Step Four, use a pH test paper to detect the acidity and alkalinity of the medicinal liquid every 20 minutes to ensure that it is maintained within the range of 5.5 - 6.

0.

6. The processing method of a treatment formula for lumbar spondylosis according to claim 4, characterized in that: For the constant temperature water bath heating described in Step Four, the water bath maintains a low-temperature concentration environment of 60 - 65°C, and at the same time turn on the magnetic stirrer to stir at a constant speed of 30 revolutions per minute.

7. A processing method for a treatment formula for lumbar spondylosis according to claim 4, characterized in that: When the cotton cloth bags of frankincense and myrrh described in Step Two are hung inside the ceramic medicine pot, it is necessary to ensure that the cotton cloth bags are immersed in the liquid surface, and at the same time avoid the cotton cloth bags directly contacting the bottom of the pot.

8. A processing method for a treatment formula for lumbar spondylosis according to claim 4, characterized in that: After the secondary medicinal liquid described in Step Three is poured into the glass container containing the primary medicinal liquid, it is necessary to stir with a glass rod to ensure the mixing of the medicinal liquid.

9. The processing method of a treatment formula for lumbar spondylosis according to claim 4, characterized in that: For the medicinal material processing described in Step One, the inner yellow membrane of the gallus gallus domesticus gmelin is removed manually, the folds are gently brushed with a soft brush, and finally rinsed with clean water.