Microbial separation device for drug microbiological examination

Abstract

The invention relates to the technical field of microorganism separation devices, in particular to a microorganism separation device for drug microorganism examination, which comprises a movable frame body, and further comprises a plurality of separation cavities respectively and movably arranged on the movable frame body; the rotating assembly is arranged on the movable frame body, is connected with the multiple separation cavities and is used for synchronously driving the multiple separation cavities to rotate; the centrifugal assembly is arranged on the movable frame body, is connected with any separation cavity and is used for realizing centrifugal separation of microorganisms in the separation cavities; according to the microorganism separation device for drug microorganism inspection, an operator can sequentially treat a plurality of microorganism samples in a circulating mode under the cooperation of the rotating assembly, the centrifugal assembly and the lifting assembly, the separation efficiency is remarkably improved, and the overall treatment period is shortened.

Description

Technical Field

[0001] The present invention relates to the technical field of microbial separation devices, and particularly to a microbial separation device for pharmaceutical microbial inspection. Background Art

[0002] Pharmaceutical microbial detection mainly includes sterility test and microbial limit test. Microbial inspection plays an important role in product quality control and product R & D, involving multiple industries and fields. Before pharmaceutical microbial inspection, it is necessary to separate microorganisms first.

[0003] A microbial separation device for pharmaceutical microbial inspection with the publication number of CN117925383B. The separation device body includes a centrifugation mechanism, a separation component and a dialysis component. The top of the centrifugation mechanism is provided with a top plate. The surface of the top plate is provided with a transmission box. The bottom of both sides of the top plate is connected with columns. The bottom of the columns is provided with a bottom plate. A collection bin is placed in the middle of the bottom plate. The bottom of the separation component is provided with a discharge pipe. The bottom of the centrifugation mechanism is inserted into the embedding groove. By installing multiple dialysis components at the edge of the centrifugation mechanism in an inclined state, this microbial separation device for pharmaceutical microbial inspection can complete the preliminary separation process of microbial precipitation and supernatant during centrifugation. Cooperating with the subsequent lifting movement control of the separation component, it can achieve the purpose of rapid separation and efficient repeated separation, making the microbial separation more thorough.

[0004] However, we found in actual use that traditional separation devices can often only process one sample at a time, resulting in low overall processing efficiency. When multiple samples need to be separated, it is necessary to wait for the previous sample to complete centrifugation and discharge before processing the next sample. After centrifugal separation, the operator needs to take out the sample from the separation device and collect the supernatant and precipitate parts separately, which undoubtedly prolongs the overall processing cycle and increases the separation time of microorganisms. For this reason, we propose a microbial separation device for pharmaceutical microbial inspection. Summary of the Invention

[0005] One technical problem to be solved by the present application is: how to design a microbial separation device for pharmaceutical microbial inspection that can process multiple microbial samples in sequence.

[0006] To solve the above technical problem, the embodiment of the present application provides a microbial separation device for pharmaceutical microbial inspection, including a movable frame body, and further including:

[0007] Multiple separation chambers, and the multiple separation chambers are respectively movably arranged on the movable frame body;

[0008] A rotating assembly, which is arranged on the moving frame and connected to multiple separation chambers, and is used to synchronously drive the multiple separation chambers to rotate;

[0009] A centrifugal assembly, which is arranged on the moving frame and connected to any one of the separation chambers, and is used to achieve centrifugal separation of microorganisms in the separation chamber;

[0010] A lifting assembly, which is arranged on the moving frame and connected to any one of the separation chambers, and is used to automatically discharge the supernatant part and the precipitate part after separation in sequence.

[0011] In some embodiments, the rotating assembly includes a fixed shaft rotatably arranged on the moving frame. An installation seat is arranged on the fixed shaft, and multiple separation chambers are respectively and evenly arranged on the installation seat. A driving motor is arranged on the moving frame, and the output end of the driving motor is connected to the fixed shaft.

[0012] In some embodiments, each separation chamber includes a collecting annular plate rotatably arranged on the installation seat. A separation main pipe is arranged on the collecting annular plate. A separation sub-pipe is slidably arranged on the separation main pipe. A plurality of return springs and multi-stage telescopic rods are arranged between the separation sub-pipe and the collecting annular plate, and the multi-stage telescopic rods are respectively arranged inside the return springs.

[0013] In some embodiments, the centrifugal assembly includes a first push rod arranged on the moving frame. An installation plate is arranged at the end of the first push rod. A centrifugal motor is arranged on the installation plate. A driving shaft connected to the output end of the centrifugal motor is arranged on the installation plate. A driving gear is arranged on the driving shaft, and an external gear ring meshing with the driving gear is arranged on the collecting annular plate.

[0014] In some embodiments, a drain pipe is arranged on the collecting annular plate. A rotating shaft is rotatably arranged at the bottom of the separation main pipe. A sealing plate is arranged on the rotating shaft for sealing the separation main pipe. A locking member is arranged between the separation main pipe and the rotating shaft for locking and positioning the rotating shaft and the sealing plate.

[0015] In some embodiments, the locking member includes a fixed seat arranged outside the separation main pipe. A circular through hole is provided in the middle of the fixed seat, and the circular through hole is coaxially arranged with the rotating shaft. A plurality of positioning springs are arranged in the fixed seat. Positioning balls are arranged at the ends of the plurality of positioning springs. A convex column is arranged on the rotating shaft, and a clamping groove cooperating with the positioning ball is provided on the convex column.

[0016] In some embodiments, the lifting assembly includes a second push rod disposed on the moving frame body. An extrusion member is disposed at the end of the second push rod for squeezing the separated secondary pipeline and controlling the rotation of the sealing plate. A precipitation collection box is disposed on the moving frame body, and a supernatant collection box is disposed on the moving frame body. A conical receiving pipe matching the drain pipe is disposed on the supernatant collection box.

[0017] In some embodiments, the extrusion member includes an extrusion plate disposed at the end of the second push rod. A plurality of push rods with different sizes are disposed on the extrusion plate. The plurality of push rods are attached to the top side wall of the separated secondary pipeline, and chamfering treatment is performed on one side of the plurality of push rods close to the separated secondary pipeline. A connecting rod is disposed on the extrusion plate, a rack is disposed on the connecting rod, and a fixed gear meshing with the rack is disposed on the rotating shaft.

[0018] In some embodiments, a pump body communicating with the supernatant collection box is disposed on the moving frame body. A liquid adding pipe for adding the microbial liquid to be separated into the separated main pipeline is disposed on the pump body.

[0019] In some embodiments, the connecting rod includes a fixed sleeve rod disposed on the extrusion plate. An adjusting rod is slidably disposed in the fixed sleeve rod, and a fastening bolt for locking the adjusting rod is disposed on the fixed sleeve rod.

[0020] The present invention has at least the following beneficial effects:

[0021] 1. The device is designed with multiple separation chambers, which can sequentially process multiple microbial samples in a cyclic manner, significantly improving the separation efficiency. Driven by the rotating assembly, the multiple separation chambers can rotate synchronously, facilitating the unloading of samples and reducing the operation time.

[0022] 2. The centrifugation assembly can perform centrifugation operations on any separation chamber, realizing the precise separation of microbial samples. The driving mode of the centrifugation motor is through gear transmission, ensuring the stable application of centrifugal force and improving the separation effect.

[0023] 3. The lifting assembly can automatically discharge the separated supernatant and precipitation parts in sequence through the cooperation of the second push rod and the extrusion member, reducing manual operation and improving the degree of automation. The design of the extrusion member takes into account the extrusion of the separated secondary pipeline and the control of the sealing plate, ensuring the accuracy and integrity of liquid discharge. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0025] Figure 2 It is a schematic diagram of the overall structure of the present invention from another aspect;

[0026] Figure 3 Schematic diagram of the structure of multiple separation chambers of the present invention;

[0027] Figure 4 For the present invention Figure 3 Partial structural sectional view;

[0028] Figure 5 Schematic diagram of the structure of the centrifugal mechanism of the present invention;

[0029] Figure 6 Schematic diagram of the partial structure of a single separation chamber and the lifting assembly of the present invention;

[0030] Figure 7 Partial sectional structure diagram of a single separation chamber and the lifting assembly of the present invention;

[0031] Figure 8 Partial sectional structure diagram of a single separation chamber of the present invention;

[0032] Figure 9 Overall partial sectional structure diagram of the present invention;

[0033] Figure 10 For the present invention Figure 9 Enlarged structure diagram of area A in the present invention;

[0034] Figure 11 Overall structure diagram of Embodiment 2 of the present invention;

[0035] Figure 12 For the present invention Figure 11 Enlarged structure diagram of area B in the present invention;

[0036] Figure 13 Structure diagram of Embodiment 3 of the present invention;

[0037] Figure 14 For the present invention Figure 13 Enlarged structure diagram of area C in the present invention.

[0038] In the figure: 1. Moving frame; 2. Separation chamber; 21. Collection annular plate; 22. Main separation pipeline; 23. Sub-separation pipeline; 24. Return spring; 25. Multi-stage telescopic rod; 3. Rotating assembly; 31. Fixed shaft; 32. Mounting seat; 33. Driving motor; 4. Centrifugal assembly; 41. First push rod; 42. Mounting plate; 43. Centrifugal motor; 44. Driving shaft; 45. Driving gear; 46. External gear ring; 5. Locking member; 51. Fixed seat; 52. Positioning spring; 53. Positioning ball; 54. Convex column; 55. Card slot; 6. Lifting assembly; 61. Second push rod; 62. Precipitation collection box; 63. Supernatant collection box; 64. Conical feeding pipe; 7. Extrusion member; 71. Extrusion plate; 72. Poking rod; 73. Connecting rod; 74. Rack; 75. Fixed gear; 8. Drain pipe; 9. Rotating shaft; 10. Sealing plate; 11. Pump body; 12. Liquid adding pipe; 13. Fixed sleeve rod; 14. Adjusting rod; 15. Tightening bolt. Detailed implementation manner

[0039] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0040] Embodiment 1

[0041] Please refer to Figures 1 - 10 , the present invention provides a technical solution:

[0042] A microbial separation device for pharmaceutical microbial inspection includes a moving frame 1. The moving frame 1 is a common existing structure and will not be elaborated here. The bottom of the moving frame 1 is provided with self-locking universal wheels that can provide real-time self-locking. It also includes:

[0043] Multiple separation chambers 2. The multiple separation chambers 2 are respectively movably arranged on the moving frame 1. In this solution, the number of separation chambers 2 is 3. One is the separation chamber 2 that is centrifuging, and the other two are separation chambers 2 to be centrifuged. And one of these two has the function of feeding materials, but it is not limited to 3;

[0044] A rotating assembly 3. The rotating assembly 3 is arranged on the moving frame 1 and is connected to the multiple separation chambers 2 to synchronously drive the multiple separation chambers 2 to rotate;

[0045] The rotating assembly 3 includes a fixed shaft 31 rotatably arranged on the moving frame 1. An installation base 32 is arranged on the fixed shaft 31. A plurality of the separation chambers 2 are respectively and evenly arranged on the installation base 32. A driving motor 33 is arranged on the moving frame 1, and the output end of the driving motor 33 is connected to the fixed shaft 31;

[0046] The driving motor 33 drives the fixed shaft 31 to rotate, and the installation base 32 located on the fixed shaft 31 will also rotate accordingly;

[0047] Each of the separation chambers 2 includes a collecting annular plate 21 rotatably arranged on the installation base 32. A separation main pipe 22 is arranged on the collecting annular plate 21. A separation sub-pipe 23 is slidably arranged on the separation main pipe 22. A plurality of return springs 24 and multi-stage telescopic rods 25 are arranged between the separation sub-pipe 23 and the collecting annular plate 21, and the multi-stage telescopic rods 25 are respectively arranged inside the return springs 24;

[0048] The collecting annular plate 21 and the separation main pipe 22 are fixedly connected, and can be fixed by welding, which makes a collecting area formed between the two. When the separation sub-pipe 23 is extruded and moves downward, the supernatant part will directly fall into this collecting area, and can be controlled by the valve on the drain pipe 8. The return spring 24 is compressed synchronously when the separation sub-pipe 23 is extruded, which enables the return spring 24 to ensure the reset of the separation sub-pipe 23 when the extrusion force disappears. During the lifting process of the separation sub-pipe 23, the multi-stage telescopic rod 25 ensures the radial displacement of the separation sub-pipe 23;

[0049] A centrifugal assembly 4 is arranged on the moving frame 1 and is connected to any one of the separation chambers 2 for centrifugally separating the microorganisms in the separation chamber 2;

[0050] The centrifugal assembly 4 includes a first push rod 41 arranged on the moving frame 1. An installation plate 42 is arranged at the end of the first push rod 41. A centrifugal motor 43 is arranged on the installation plate 42. A driving shaft 44 connected to the output end of the centrifugal motor 43 is arranged on the installation plate 42. A driving gear 45 is arranged on the driving shaft 44. An external gear ring 46 meshing with the driving gear 45 is arranged on the collecting annular plate 21;

[0051] When the microorganism liquid to be separated rotates below the centrifugal motor 43, the first push rod 41 drives the installation plate 42, the centrifugal motor 43 and the driving gear 45 to move downward, so that the driving gear 45 meshes with the external gear ring 46. Then the centrifugal motor 43 starts to drive the driving shaft 44 and the driving gear 45 to rotate, which can drive the external gear ring 46 to rotate, so that the collecting annular plate 21, the separation main pipe 22 and the separation sub-pipe 23 rotate synchronously, realizing the centrifugal work of the microorganism liquid to be separated;

[0052] A drain pipe 8 is provided on the collecting annular plate 21. A rotating shaft 9 is rotatably provided at the bottom of the main separation pipe 22. A sealing plate 10 is provided on the rotating shaft 9 for sealing the main separation pipe 22. A locking member 5 is provided between the main separation pipe 22 and the rotating shaft 9 for locking and positioning the rotating shaft 9 and the sealing plate 10. When in use, in order to ensure the sealing performance, a layer of rubber gasket can be provided on the inner wall of the main separation pipe 22 or the outer wall of the sealing plate 10;

[0053] The locking member 5 includes a fixed seat 51 provided on the outside of the main separation pipe 22. A circular through hole is provided in the middle of the fixed seat 51, and the circular through hole is coaxially arranged with the rotating shaft 9. A plurality of positioning springs 52 are provided in the fixed seat 51. Positioning balls 53 are provided at the ends of the plurality of positioning springs 52. A convex column 54 is provided on the rotating shaft 9, and a clamping groove 55 that cooperates with the positioning ball 53 is provided on the convex column 54;

[0054] When no material is being fed, the sealing plate 10 is in close contact with the inner wall of the main separation pipe 22 to achieve sealing. The positioning spring 52 will press the positioning ball 53, causing the positioning ball 53 to be stuck in the clamping groove 55 to prevent rotation;

[0055] A lifting assembly 6, the lifting assembly 6 is provided on the moving frame 1 and is connected to any one of the separation chambers 2 for automatically discharging the separated supernatant part and precipitate part in sequence;

[0056] The lifting assembly 6 includes a second push rod 61 provided on the moving frame 1. An extrusion member 7 is provided at the end of the second push rod 61 for squeezing the secondary separation pipe 23 and controlling the rotation of the sealing plate 10. A precipitate collection box 62 is provided on the moving frame 1. A supernatant collection box 63 is provided on the moving frame 1. A conical receiving pipe 64 that cooperates with the drain pipe 8 is provided on the supernatant collection box 63. The precipitate collection box 62 is a movable structure and can be pulled by the handle provided thereon. The setting of the conical receiving pipe 64 can make the supernatant discharged from the drain pipe 8 fall better into the supernatant collection box 63;

[0057] The extrusion member 7 includes an extrusion plate 71 provided at the end of the second push rod 61. A plurality of dial rods 72 with different sizes are provided on the extrusion plate 71. The plurality of dial rods 72 are in contact with the top side wall of the secondary separation pipe 23, and the sides of the plurality of dial rods 72 close to the secondary separation pipe 23 are chamfered. A connecting rod 73 is provided on the extrusion plate 71. A rack 74 is provided on the connecting rod 73. A fixed gear 75 that meshes with the rack 74 is provided on the rotating shaft 9;

[0058] The second push rod 61 drives the extrusion plate 71 and the lever 72 to move downward. When the lever 72 contacts the separation sub-pipe 23, it will drive the separation sub-pipe 23 to move downward together (compressing the return spring 24 and causing the multi-stage telescopic rod 25 to contract). At this time, the rack 74 does not contact the fixed gear 75, and the supernatant liquid falls into the collection area. After continuing to move downward, the rack 74 contacts the fixed gear 75 and drives the fixed gear 75 and the rotating shaft 9 to rotate, opening the sealing plate 10, so that the sediment part inside the separation main pipe 22 and the separation sub-pipe 23 falls into the sediment collection box 62 at the bottom.

[0059] During use, the operator first adds the microbial liquid to be separated into any one of the separation chambers 2, and then drives the motor 33 to drive the fixed shaft 31 to rotate. The mounting seat 32 located on the fixed shaft 31 will also rotate accordingly, rotating the separation chamber 2 with the microbial liquid to be separated to the bottom of the centrifugal motor 43. During the rotation process, the microbial liquid to be separated can also be added to the other two separation chambers 2.

[0060] After the separation chamber 2 rotates to below the centrifugal motor 43, the first push rod 41 drives the mounting plate 42, the centrifugal motor 43 and the drive gear 45 to move downward, so that the drive gear 45 meshes with the external gear ring 46. Then the centrifugal motor 43 starts to drive the drive shaft 44 and the drive gear 45 to rotate, and then can drive the external gear ring 46 to rotate, which makes the collection annular plate 21, the separation main pipe 22 and the separation sub-pipe 23 rotate synchronously, realizing the centrifugation of the microbial liquid to be separated.

[0061] After the separation in the separation chamber 2 is completed, the first push rod 41 starts to move the drive gear 45 upward, and then starts the drive motor 33 again to rotate the separation chamber 2 to below the second push rod 61. At the same time, another separation chamber 2 rotates to below the centrifugal motor 43 to start a new centrifugation operation, and the separation chamber 2 located below the second push rod 61 starts the feeding operation. Specifically:

[0062] The second push rod 61 drives the extrusion plate 71 and the lever 72 to move downward. When the lever 72 contacts the separation sub-pipe 23, it will drive the separation sub-pipe 23 to move downward together (compressing the return spring 24 and causing the multi-stage telescopic rod 25 to contract). At this time, the rack 74 does not contact the fixed gear 75, and the supernatant liquid falls into the collection area. After continuing to move downward, the rack 74 contacts the fixed gear 75 and drives the fixed gear 75 and the rotating shaft 9 to rotate, opening the sealing plate 10, so that the sediment part inside the separation main pipe 22 and the separation sub-pipe 23 falls into the sediment collection box 62 at the bottom.

[0063] Then the second push rod 61 starts to reset the extrusion plate 71 and the lever 72. Under the action of the return spring 24, the multi-stage telescopic rod 25 and the separation sub-pipe 23 are reset for the next use.

[0064] Embodiment 2

[0065] Please refer to Figures 11 - 12 , the present invention provides a technical solution:

[0066] Different from Embodiment 1, a pump body 11 communicating with the supernatant collection box 63 is provided on the movable frame body 1, and a liquid adding pipe 12 for injecting the microbial liquid to be separated into the separation main pipe 22 is provided on the pump body 11. For the supernatant after one centrifugation, if it is considered that there are still solid substances, the supernatant in the supernatant collection box 63 can be sent into the separation chamber 2 again through the pump body 11 for secondary centrifugation and separation. In this solution, after the precipitation part is discharged and the separation sub-pipe 23 is reset, the supernatant is directly added to the just-fed separation chamber 2.

[0067] Embodiment 3

[0068] Please refer to Figures 13 - 14 , the present invention provides a technical solution:

[0069] Different from Embodiment 1, the connecting rod 73 includes a fixed sleeve rod 13 provided on the extrusion plate 71, an adjusting rod 14 is slidably arranged in the fixed sleeve rod 13, and a fastening bolt 15 for locking the adjusting rod 14 is provided on the fixed sleeve rod 13;

[0070] In this solution, adjusting the fastening bolt 15 can move the adjusting rod 14 up and down and fix it again at an appropriate position. This fixing method enables the position of the rack 74 relative to the extrusion plate 71 to be adjusted, that is, the descending height of the separation sub-pipe 23 can be adjusted;

[0071] When there are more precipitates in the microbial liquid to be separated, the adjusting rod 14 can be moved downwards so that the rack 74 contacts the fixed gear 75 earlier, so that more precipitation parts at the bottom can fall into the precipitation collection box 62. On the contrary, when there are fewer precipitates in the microbial liquid to be separated, the adjusting rod 14 can be moved upwards so that the rack 74 contacts the fixed gear 75 later, so that more supernatant parts in the upper layer can fall into the supernatant collection box 63.

[0072] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprises", "comprising" or any other variation thereof is intended to cover a non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements, but also other elements not expressly listed, or elements inherent to such process, method, article or device.

[0073] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention.

Claims

1. A microbial separation device for pharmaceutical microbial inspection, comprising a movable frame body (1), characterized in that: It further includes: A plurality of separation chambers (2), and a plurality of the separation chambers (2) are respectively movably arranged on the movable frame body (1); A rotating assembly (3), the rotating assembly (3) is arranged on the movable frame body (1) and is connected to a plurality of the separation chambers (2) for synchronously driving the plurality of separation chambers (2) to rotate; A centrifugal assembly (4), the centrifugal assembly (4) is arranged on the movable frame body (1) and is connected to any one of the separation chambers (2) for centrifugally separating the microorganisms in the separation chamber (2); A lifting assembly (6), the lifting assembly (6) is arranged on the movable frame body (1) and is connected to any one of the separation chambers (2) for automatically discharging the separated supernatant part and precipitate part in sequence.

2. The microbial separation device for pharmaceutical microbial inspection according to claim 1, characterized in that: The rotating assembly (3) includes a fixed shaft (31) rotatably arranged on the movable frame body (1), an installation seat (32) is arranged on the fixed shaft (31), and a plurality of the separation chambers (2) are respectively and uniformly arranged on the installation seat (32). A driving motor (33) is arranged on the movable frame body (1), and the output end of the driving motor (33) is connected to the fixed shaft (31).

3. The microbial isolation device for pharmaceutical microbial inspection according to claim 2, wherein: Each of the separation chambers (2) includes a collecting annular plate (21) rotatably arranged on the installation seat (32). A separation main pipe (22) is arranged on the collecting annular plate (21). A separation sub-pipe (23) is slidably arranged on the separation main pipe (22). A plurality of return springs (24) and multi-stage telescopic rods (25) are arranged between the separation sub-pipe (23) and the collecting annular plate (21), and the multi-stage telescopic rods (25) are respectively arranged inside the return springs (24).

4. The microbial isolation device for pharmaceutical microbial inspection according to claim 3, wherein: The centrifugal assembly (4) includes a first push rod (41) arranged on the movable frame body (1). An installation plate (42) is arranged at the end of the first push rod (41). A centrifugal motor (43) is arranged on the installation plate (42). A driving shaft (44) connected to the output end of the centrifugal motor (43) is arranged on the installation plate (42). A driving gear (45) is arranged on the driving shaft (44), and an external gear ring (46) meshing with the driving gear (45) is arranged on the collecting annular plate (21).

5. The microbial isolation device for pharmaceutical microbial inspection according to claim 4, characterized in that: A drain pipe (8) is arranged on the collecting annular plate (21). A rotating shaft (9) is rotatably arranged at the bottom of the separation main pipe (22). A sealing plate (10) is arranged on the rotating shaft (9) for sealing the separation main pipe (22). A locking member (5) is arranged between the separation main pipe (22) and the rotating shaft (9) for locking and positioning the rotating shaft (9) and the sealing plate (10).

6. The microbial isolation device for pharmaceutical microbial inspection according to claim 5, wherein: The locking member (5) includes a fixed seat (51) disposed outside the separation main pipe (22). A circular through hole is provided in the middle of the fixed seat (51), and the circular through hole and the rotating shaft (9) are coaxially arranged. A plurality of positioning springs (52) are arranged in the fixed seat (51). Positioning balls (53) are arranged at the ends of the plurality of positioning springs (52). A convex column (54) is arranged on the rotating shaft (9), and a card slot (55) matching with the positioning ball (53) is formed on the convex column (54).

7. The microbial isolation device for pharmaceutical microbial inspection according to claim 6, characterized in that: The lifting assembly (6) includes a second push rod (61) arranged on the moving frame body (1). An extrusion member (7) is arranged at the end of the second push rod (61) for squeezing the separation secondary pipe (23) and controlling the rotation of the sealing plate (10). A sediment collection box (62) is arranged on the moving frame body (1). A supernatant collection box (63) is arranged on the moving frame body (1). A conical receiving pipe (64) matching with the drain pipe (8) is arranged on the supernatant collection box (63).

8. The microbial isolation device for pharmaceutical microbial inspection according to claim 7, wherein: The extrusion member (7) includes an extrusion plate (71) arranged at the end of the second push rod (61). A plurality of dial rods (72) with different sizes are arranged on the extrusion plate (71). The plurality of dial rods (72) are attached to the top side wall of the separation secondary pipe (23), and chamfering treatments are performed on the sides of the plurality of dial rods (72) close to the separation secondary pipe (23). A connecting rod (73) is arranged on the extrusion plate (71). A rack (74) is arranged on the connecting rod (73). A fixed gear (75) meshing with the rack (74) is arranged on the rotating shaft (9).

9. The microbial separation device for pharmaceutical microbial inspection according to claim 7, characterized in that: A pump body (11) communicating with the supernatant collection box (63) is arranged on the moving frame body (1). A liquid adding pipe (12) for adding the microbial liquid to be separated into the separation main pipe (22) is arranged on the pump body (11).

10. The microbial separation device for pharmaceutical microbial inspection according to claim 8, characterized in that: The connecting rod (73) includes a fixed sleeve rod (13) arranged on the extrusion plate (71). An adjusting rod (14) is slidably arranged in the fixed sleeve rod (13). A fastening bolt (15) for locking the adjusting rod (14) is arranged on the fixed sleeve rod (13).

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