Physiological regulation composition for puerperium and sequential application method thereof

Abstract

The invention relates to the technical field of medicinal and edible food processing, and particularly provides a puerperium physiological regulation composition and a sequential application method thereof.The composition is prepared from, by weight, 8-10 parts of peach kernels, 4-6 parts of dried ginger, 8-10 parts of milkvetch roots, 9-11 parts of hawthorn fruits, 14-16 parts of white hyacinth beans, 4-6 parts of longan aril and 0.5-1.5 parts of stevia rebaudiana. Wherein the weight ratio of the peach kernels to the haws is (0.9-1.1): 1. Meanwhile, different stages of postpartum recovery are accurately matched, key postpartum 42 days are divided into three different time windows of 0-14 days, 15-28 days and 29-42 days, and a specially designed electuary formula is used in each time period, so that key demands of the body in different recovery stages are more accurately met, main problems in different stages are accurately solved, and the curative effect of postpartum recovery is improved. The effects of removing blood stasis, repairing and nursing are achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of processing of foods homologous to medicine and food, and particularly relates to a composite composition for postpartum female physiological recovery and its application method based on a timeline. Background Art

[0002] The puerperium mainly refers to a period from the end of childbirth to the time when the parturient's body returns to the pre-pregnancy state. Due to a large amount of bleeding, sweating, low back pain, and abdominal pain, the parturient consumes a lot of physical strength, qi and blood, and the muscles and bones are very weak. The body is in a state of "insufficient blood and deficient qi", and it is very easy to be invaded by diseases at this time. Therefore, it takes a period of conditioning to recover health. During this period, moderate exercise and rest, appropriate food supplements and dietary therapies are needed to make the uterus return to the size before childbirth, and at the same time, qi and blood can be restored, even better than before.

[0003] At present, postpartum female physiological recovery faces three major technical bottlenecks: Insufficient functional synergy: At present, parturients often drink brown sugar water or ginger sugar water during the confinement period to achieve the purpose of nourishing blood and promoting blood circulation, postpartum blood tonic, and discharging lochia. However, the traditional blood tonic methods have a single function and limited effects. Therefore, it is necessary to study a special granule for parturients to drink during the confinement period.

[0004] Lack of physiological adaptability: Clinical studies have shown that the daily average reduction rate of uterine volume in the first week after childbirth is 3.2 times that in the fourth week, and the recovery speed of pelvic floor muscle strength in the second week is 40% faster than that in the sixth week. However, the existing technologies have not yet established an intervention plan that matches the dynamic physiological changes.

[0005] Defect in dosage form applicability: Traditional decoctions need to be decocted and are inconvenient to carry. And due to the problem of component compatibility not being solved in ordinary granules, the degradation rate of key active ingredients (such as amygdalin in peach kernels) during storage is as high as 35%.

[0006] In summary, there is an urgent need to develop an edible composition that can dynamically adapt to postpartum physiological changes, has multi-system synergistic regulation, and high stability. Summary of the Invention

[0007] Aiming at the deficiencies of the existing technology, the purpose of the present invention is to provide a physiological regulation composition for the puerperium and its sequential application method, which solves the contradiction problem between the sequential changes of physiological states and the static formula during the postpartum recovery process.

[0008] To achieve the above object, the present invention provides the following technical solutions: A physiological regulation composition for the puerperium is composed of the following raw materials in parts by weight: 8 - 10 parts of peach kernels, 4 - 6 parts of dried ginger, 8 - 10 parts of astragalus membranaceus, 9 - 11 parts of hawthorn, 14 - 16 parts of white hyacinth beans, 4 - 6 parts of longan pulp, 0.5 - 1.5 parts of stevia rebaudiana, wherein the weight ratio of peach kernels to hawthorn is (0.9 - 1.1):1.

[0009] Preferably, the preparation process of the above composition comprises the following steps: S1: Extract peach kernels and hawthorn by supercritical CO2 extraction at a pressure of 28 - 32 MPa and a temperature of 42 - 48°C; S2: Extract dried ginger and astragalus membranaceus by refluxing with 70% ethanol at a solid - liquid ratio of 1:10 - 12; S3: Extract white hyacinth beans and longan aril by aqueous extraction after cellulase hydrolysis at an enzymatic hydrolysis temperature of 38 - 40°C.

[0010] A chronological application method of a physiological regulation composition for the puerperium, comprising three postpartum time periods: A1: Take a preparation containing 9 - 10 g of peach kernels and 4 - 6 g of dried ginger daily from the 1st to the 14th day after childbirth; A2: Take a preparation containing 15 - 16 g of white hyacinth beans and 9 - 11 g of hawthorn daily from the 15th to the 28th day after childbirth; A3: Take a preparation containing 5 - 6 g of longan aril and 4 - 6 g of lily daily from the 29th to the 42nd day after childbirth.

[0011] Preferably, the addition amount of Chinese yam in stage A2 is 8 - 10 parts, and forms a weight ratio of (0.5 - 0.7):1 with white hyacinth beans.

[0012] A solid granule, with each unit dose being 3.0 ± 0.2 g, and the dissolution time ≤ 15 seconds in water at 25°C.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The present invention precisely matches different stages of postpartum recovery, divides the critical 42 days after childbirth into three different time windows: 0 - 14 days, 15 - 28 days, and 29 - 42 days. Each time period uses a specially designed granule formula to more precisely solve the key needs of the body at different recovery stages, accurately solve the main problems at different times, and achieve the goals of first removing stasis, then repairing, and finally recuperating.

[0014] 2. The combined granules of the present invention can enable the body of the new mother to recover faster. The time for removing stasis is greatly shortened compared with traditional methods, helping the uterus to contract and tighten faster and better. It can also effectively improve problems such as postpartum pelvic floor relaxation, poor complexion, and backache, enabling the new mother to recover to a better and more comfortable overall state, with a more stable mood, and reducing restlessness and insomnia.

[0015] 3. All raw materials of the present invention are homologous medicinal and edible materials approved by the state to be used as food, such as hawthorn, white hyacinth beans, longan aril, etc. They are 100% natural, safe to eat, without worrying about drug side effects, and will not affect breastfeeding the baby, nor cause common adverse reactions such as gastrointestinal discomfort.

[0016] 4. The composite composition of the present invention can be directly made into small-bag granule instant drinks, which are convenient to brew and can supplement energy at any time.

[0017] 5. The present invention uses advanced extraction techniques and special processes to efficiently extract and protect key active ingredients such as amygdalin in peach kernels. After being flushed with water, it can be dissolved and absorbed well, and more than 95% of the key active ingredients can still be retained after being stored for half a year. It is safe, reliable and effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic process flow diagram for the directional extraction of the composite composition for the physiological recovery of postpartum women according to the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0019] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below through examples and in conjunction with the drawings. It should be understood that the specific examples described herein are only used to explain the present invention and are not used to limit the present invention.

[0020] Example 1: A preparation process for a composite composition for the physiological recovery of postpartum women: Raw material pretreatment: Peach kernels and hawthorn: After removing the cores, they are dried at 60°C to a moisture content ≤ 8%, and then pulverized through an 80-mesh sieve; Astragalus membranaceus and dried ginger: Ultrafinely pulverized to a particle size ≤ 50 μm (using a FL-300 type air flow pulverizer); White hyacinth beans: After steam inactivation treatment (100°C / 5 min), they are dried at low temperature.

[0021] Directional extraction process: (1) Grouping treatment of raw materials and extraction methods: Group of peach kernels and hawthorn: Extraction technique: Supercritical CO2 fluid extraction; Process parameters: Pressure: 30 MPa (ensuring complete dissolution of fat-soluble components); Temperature: 45°C (low temperature to prevent thermal decomposition of amygdalin); CO2 flow rate: 25 L / min; The degradation rate of amygdalin in peach kernels increases suddenly when the temperature > 50°C (experimental data: the loss rate at 60°C > 40%). Supercritical extraction at 45°C can retain ≥ 95% of the active ingredients (verified by HPLC).

[0022] Group of dried ginger and Astragalus membranaceus: Extraction technique: Ethanol reflux extraction; Process parameters: Ethanol concentration: 70% (the optimal polarity balance point); Ratio of material to liquid: 1:12 (g / mL); Temperature: 80°C ± 2°C; Time: 2 hours (the dissolution rate of astragaloside reaches the peak value); Gradient temperature rising program is adopted: 50°C (0.5 h) → 70°C (0.5 h) → 80°C (1 h) to avoid high-temperature oxidation of gingerol.

[0023] White hyacinth bean and longan aril group: Extraction technology: combined use of biological enzymolysis and hot water extraction; Step-by-step process: a. Enzymolysis pretreatment: Type of enzyme: cellulase (activity unit ≥ 8000 U / g); Dosage: 0.5% of the raw material weight; Conditions: water bath at 38 - 40°C, pH 5.0, time 2 hours; b. Hot water extraction: Temperature: 90°C; Time: 1 hour; Stirring rate: 120 rpm.

[0024] (2) Merging and concentration of the extract: Mixing method: mix the three groups of extracts according to the volume ratio of 1:1:1.2 (peach kernel group: ginger and astragalus group: hyacinth bean and longan aril group); Concentration process: Equipment: vacuum thin-film concentrator; Temperature: 60°C ± 5°C (to prevent loss of heat-sensitive components); Endpoint determination: the relative density of the concentrated solution reaches 1.18 ± 0.02 g / cm³ (measured at 25°C).

[0025] (3) Spray drying and forming Inlet air temperature: 185°C ± 3°C, instant drying to lock the active molecular structure; outlet air temperature: 85°C ± 2°C, to prevent overheating and coking of the material; atomization pressure: 0.25 MPa, to ensure that the particle size ≤ 80 μm; residence time of the material: ≤ 15 seconds, to reduce heat damage.

[0026] In a further embodiment: the content of amygdalin in the peach kernel extract ≥ 2.3% (detected by HPLC), The retention rate of 6-gingerol in the dried ginger extract ≥ 90%.

[0027] Example 2: Verification by application in different time periods (animal experiment): The experimental design is shown in the following table: Table 1: Experimental design scheme: 。

[0028] The experimental parameter standards are as follows: Animal strain: Sprague-Dawley rats, female, SPF grade; Body weight range: 230 ± 10 g (at mating); Gavage dose: 1.5 g / kg / d (based on human equivalent dose); Intervention period: 0 - 42 days postpartum, simulating the human puerperium.

[0029] The experimental results are shown in the following table: Table 2: Comparison of key indicators on the 42nd day postpartum: 。

[0030] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope recorded in this specification.

[0031] The above-described embodiments only represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the present invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention patent should be subject to the appended claims.

Claims

1. A physiological regulation composition for the puerperium, characterized in that: It is composed of the following raw materials in parts by weight: 8 - 10 parts of peach kernels, 4 - 6 parts of dried ginger, 8 - 10 parts of astragalus membranaceus, 9 - 11 parts of hawthorn, 14 - 16 parts of white hyacinth beans, 4 - 6 parts of longan pulp, 0.5 - 1.5 parts of stevia, wherein the weight ratio of peach kernels to hawthorn is (0.9 - 1.1):

1.

2. The composition according to claim 1, characterized in that: The preparation process includes the following steps: S1: The peach kernels and hawthorn are extracted by supercritical CO2, with a pressure of 28 - 32 MPa and a temperature of 42 - 48 °C; S2: The dried ginger and astragalus membranaceus are extracted by reflux with 70% ethanol, and the ratio of material to liquid is 1:10 - 12; S3: The white hyacinth beans and longan pulp are enzymatically hydrolyzed by cellulase and then extracted with water, and the enzymatic hydrolysis temperature is 38 - 40 °C.

3. A chronological application method of the physiological regulation composition for the puerperium as described in claim 1, characterized in that : A1: Take a preparation containing 9 - 10 g of peach kernels and 4 - 6 g of dried ginger every day from the 1st to the 14th day after childbirth; A2: Take a preparation containing 15 - 16 g of white hyacinth beans and 9 - 11 g of hawthorn every day from the 15th to the 28th day after childbirth; A3: Take a preparation containing 5 - 6 g of longan pulp and 4 - 6 g of lily every day from the 29th to the 42nd day after childbirth.

4. The timing application method according to claim 3, characterized in that: In stage A2, the addition amount of Chinese yam is 8 - 10 parts, and it forms a weight ratio of (0.5 - 0.7):1 with white hyacinth beans.

5. A solid granule, comprising the composition described in claims 1-2, characterized in that: Each unit dose is 3.0 ± 0.2 g, and in water at 25 °C, the dissolution time ≤ 15 seconds.

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