Essence composition containing lipidosome with acne removing effect as well as preparation method and application of essence composition

Abstract

The invention discloses an essence composition containing lipidosome with an acne removing effect as well as a preparation method and application of the essence composition. The essence composition comprises the following components: 2-30% of lipidosome with the acne removing effect, 0.5-15% of a skin conditioner, 5-40% of a humectant, 0.1-3% of a preservative, 0.15-10% of a thickening agent, 0.05-5% of a chelating agent, 0.01-3% of a pH regulator and deionized water. The lipidosome with the acne removing effect is prepared from the following components in percentage by weight: 1.5 to 2.5 percent of white willow bark extract, 0.3 to 0.7 percent of Pinosine, 2 to 4 percent of rhizoma bletillae root extract, 4 to 6 percent of nicotinamide, 0.15 to 0.35 percent of oligopeptide-3, 7 to 12 percent of lecithin and 1 to 2 percent of cholesterol. In the preparation process, the lipidosome with the acne removal effect is reasonably compounded with other auxiliary material matrixes, so that efficient transmission and absorption of active ingredients can be promoted, irritation to skin can be effectively relieved, meanwhile, the overall effect of the essence is enhanced, the essence has mildness and high efficiency, and the high-efficiency requirement of consumers for the acne removal skin care product is met.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and mainly relates to a serum composition containing acne-removing liposomes, a preparation method thereof, and an application thereof. Background Art

[0002] Acne, medically known as acne vulgaris, is a common chronic inflammatory skin disease of the hair follicles and sebaceous glands, which often occurs in areas rich in sebaceous glands such as the face, neck, chest and back. The occurrence of acne is related to various factors, including changes in hormone levels during puberty, excessive secretion of sebaceous glands, abnormal keratinization of the hair follicle sebaceous gland duct, and infection with Propionibacterium acnes. These factors act together to cause blockage of the hair follicle sebaceous gland orifice, preventing sebum from being discharged smoothly and forming comedones. When substances such as sebum and keratinocyte debris in the comedones interact with microorganisms, inflammation is triggered, forming different types of acne such as papules and pustules.

[0003] At present, there are various acne-removing products on the market, such as facial cleansers, toners, lotions, ointments, etc., but their effects vary. Although some products can temporarily relieve acne symptoms, long-term use may cause irritation to the skin and even trigger allergic reactions. In addition, some chemical components in acne-removing products may pose potential hazards to human health. Therefore, it is of great significance to develop a safe and highly effective acne-removing product.

[0004] As a new type of drug and cosmetic carrier, liposomes have excellent biocompatibility, biodegradability and targeting. By encapsulating acne-removing active ingredients in liposomes, their stability and bioavailability can be improved, irritation to the skin can be reduced, and multiple effects such as acne removal, oil control, anti-inflammation and repair can be achieved. However, at present, there are few liposome serum compositions with acne-removing effects on the market, and there are still some problems in the preparation process and formula design, such as insignificant acne-removing effect, poor stability and unpleasant skin feel.

[0005] Therefore, the present invention aims to provide a serum composition containing acne-removing liposomes, and by optimizing the formula design and preparation process, achieve efficient and mild acne removal and ensure the safety and stability of the product. Summary of the Invention

[0006] The object of the present invention is to provide a serum composition containing acne-removing liposomes, which can effectively remove acne.

[0007] Another object of the present invention is to provide a preparation method of a serum composition containing acne-removing liposomes, which can help the acne-removing active ingredients better penetrate the sebum membrane through liposome encapsulation, promote skin absorption, and effectively exert the acne-removing effect.

[0008] Another object of the present invention is to provide an application of the above-mentioned serum composition containing acne-removing liposomes.

[0009] To achieve the above object, the present invention adopts the following technical solutions: An essence liquid composition containing liposomes with acne-removing efficacy, calculated by the total weight of the composition, is composed of the following raw materials: 2 - 30% liposomes with acne-removing efficacy; 0.5 - 15% skin conditioner; 5 - 40% moisturizer; 0.1 - 3% preservative; 0.15 - 10% thickener; 0.05 - 5% chelating agent; 0.01 - 3% pH regulator; The balance is deionized water; Among them, the liposomes with acne-removing efficacy are composed of the following raw material components: 1.5 - 2.5% white willow bark extract, 0.3 - 0.7% piperonyloxide, 2 - 4% bletilla striata root extract, 4 - 6% niacinamide, 0.15 - 0.35% oligopeptide-3, 7 - 12% lecithin, 1 - 2% cholesterol, and the mass ratio of white willow bark extract, piperonyloxide, bletilla striata root extract, niacinamide, oligopeptide-3, lecithin, cholesterol in the liposomes with acne-removing efficacy is 1:(0.2 - 0.5):(1 - 2):(2 - 3):(0.2 - 1):(4 - 5):(0.5 - 1).

[0010] Preferably, the liposomes with acne-removing efficacy are prepared by the following process: (1) Take an appropriate amount of deionized water, and successively add 1.5 - 2.5% white willow bark extract, 0.3 - 0.7% piperonyloxide, 2 - 4% bletilla striata root extract, 4 - 6% niacinamide, 0.15 - 0.35% water-soluble component of oligopeptide-3. After adding each component, stir at a low speed (300 rpm) until completely dissolved and finally form a uniform solution. Subsequently, adjust the pH value of the mixed solution to between 5.0 and 5.8 with a pH regulator; (2) In another clean container, take 7 - 12% lecithin and 1 - 2% cholesterol and dissolve them in a small amount of ethanol or propylene glycol, place them in a water bath at 40 - 45°C, and stir gently until completely dissolved; (3) Slowly pour the solution in step (2) into step (1), increase the stirring speed to 10000 - 15000 rpm, and continuously stir for 5 - 10 minutes to form a preliminary liposome-encapsulated complex; (4) Transfer the complex to a high-pressure homogenizer, set the homogenization pressure in the range of 5000 - 8000 psi, and homogenize 3 - 5 times to form nanoscale liposomes with a particle size range of 100 - 200 nm, ensuring uniform encapsulation and a high encapsulation rate; (5) Remove the residual ethanol solvent by low-temperature rotary evaporation to avoid irritation to the skin. Control the evaporation temperature below 40 °C; (6) Slowly cool the liposome solution to room temperature and add 1-2% glycerol as a stabilizer to prevent liposome aggregation and denaturation and maintain the stability of the system.

[0011] Preferably, the skin conditioner is selected from at least one of decarboxylated carnosine hydrochloride, ergothioneine, inulin, purslane extract, asiaticoside, and Lactobacillus / Soybean Ferment Lysate; The humectant is selected from at least one of glycerol, 1,3-propanediol, butanediol, 1,2-hexanediol, panthenol, betaine, trehalose, sodium hyaluronate, and sodium polyglutamate; The preservative is selected from at least one of phenoxyethanol, ethylhexylglycerin, pentylene glycol, and p-hydroxyacetophenone; the thickener is selected from at least one of xanthan gum, cetyl alcohol, carbomer, acrylate copolymer, gum arabic, and modified starch; The chelating agent is selected from at least one of disodium EDTA and octanoyl hydroxamic acid; The pH regulator is selected from at least one of citric acid, lactic acid, arginine, triethanolamine, and sodium hydroxide.

[0012] The present invention also provides a method for preparing a serum composition containing acne-removing liposomes, comprising the following steps: (1) Weigh each raw material component according to the formula requirements for standby; (2) Add the humectant, thickener, chelating agent, and preservative to the main emulsifying pot, heat up to 82 °C - 85 °C, stir until dissolved and transparent, homogenize at 3000 rpm for 3 - 5 minutes, keep stirring for 30 - 35 minutes, and turn on the cooling water (medium speed); (3) Cool the mixture obtained in step 2 to below 40 °C, and sequentially add the acne-removing liposomes, skin conditioner, and pH regulator, and stir at 1500 rpm for 15 minutes until all components are evenly mixed; (4) Take a sample to check the color, smell, and uniformity. After the initial inspection is qualified, filter and discharge to remove undissolved or residual substances in the composition to ensure the purity and stability of the serum.

[0013] Specifically, a skin care product, which contains a serum composition containing acne-removing liposomes.

[0014] The serum composition containing acne-removing liposomes encapsulated by the present invention can also be designed into other skin care product dosage forms, such as lotion, cream, gel, etc.

[0015] The beneficial effects of the present invention are as follows: This product utilizes a rational combination of active ingredients, including willow bark extract, piornine, bletilla root extract, niacinamide, and oligopeptide-3, to achieve multiple acne-removing mechanisms. Furthermore, it utilizes liposome encapsulation technology to significantly increase the penetration rate of active ingredients, allowing them to directly reach the target skin areas and enhance the acne-removing effect. The use of liposome encapsulation technology reduces the discomfort that may be caused by direct contact of active ingredients with the skin, and through a scientific formulation, alleviates the skin irritation that may be caused by high concentrations of active ingredients. In addition, the addition of moisturizers and skin conditioners further alleviates skin dryness and irritation, making it more suitable for sensitive and acne-prone skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Attachment Figure 1 Results of papule counting test at different time points. DETAILED DESCRIPTION

[0017] This invention discloses an essence composition containing acne-removing liposomes. By incorporating acne-removing liposomes, the composition effectively integrates active ingredients such as willow bark extract, piornine, bletilla striata root extract, niacinamide, and oligopeptide-3. These ingredients are rationally combined to create a synergistic effect, addressing the root cause of acne while also helping to repair pigmentation in the later stages of acne.

[0018] The present invention will be further described in detail below with reference to specific embodiments, which are only part of the present invention and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0019] The following three serum compositions containing acne-removing liposomes are provided, and their raw material compositions and proportions are shown in Table 1 below: Example 1

[0020] An essence composition containing liposomes with anti-acne effects, the ingredients of which are shown in Table 1, is prepared according to the following steps: (1)Preparation of acne-removing effect liposomes: First, weigh 200 mg of white willow bark extract, 50 mg of pioniermine, 300 mg of bletilla striata root extract, 500 mg of niacinamide and 25 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine to obtain an active ingredient mixture; Subsequently, weigh 1000 mg of lecithin and 150 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved; Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 10,000 rpm, and stir for 5 minutes to form a preliminary liposome-encapsulated complex; Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanometer level of 100 - 200 nm, ensuring uniform encapsulation and a high encapsulation rate; After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce potential irritation to the skin; Finally, cool the liposome solution to room temperature and add 1% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation, obtaining acne-removing effect liposomes with a stable system; (2)Weigh other raw material components in the essence according to the formula requirements, and reserve the obtained mixture; (3)Add the humectant, thickener, chelating agent, and preservative to the main emulsifying pot, heat up to 82 °C - 85 °C, stir until transparent, homogenize at 3000 rpm for 3 - 5 minutes, keep stirring for 30 - 35 minutes, and turn on the cooling water at medium speed to obtain a mixture; (4)Cool the mixture obtained in step (3) to below 40 °C, and sequentially add the acne-removing effect liposomes, skin conditioner, and pH regulator, and stir at 1500 rpm for 15 minutes until all components are evenly mixed; Take a sample to check the color, smell, and uniformity. After passing the initial inspection, filter and discharge to remove undissolved or residual substances in the composition to ensure the purity and stability of the essence. Example 2

[0021] An essence composition containing acne-removing effect liposomes, the ingredient list is shown in Table 1, and it is prepared according to the following steps: (1)Preparation of acne-removing lipid vesicles: First, weigh 300 mg of white willow bark extract, 75 mg of piperonyloxide, 450 mg of bletilla striata root extract, 750 mg of niacinamide, and 37.5 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine. Subsequently, weigh 1500 mg of lecithin and 225 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved. Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 15,000 rpm, and stir for 5 minutes to form a preliminary lipid vesicle-encapsulated complex. Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the lipid vesicle particle size reach the nanoscale of 100 - 200 nm, ensuring uniform encapsulation and a high encapsulation efficiency. After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce potential irritation to the skin. Finally, cool the lipid vesicle solution to room temperature and add 1.5% glycerol as a stabilizer to effectively prevent lipid vesicle aggregation and denaturation and ensure the stability of the system. (2)Weigh other raw material components in the essence according to the formula requirements and set aside. (3)Add the humectant, thickener, chelating agent, and preservative to the main emulsifying pot, heat up to 82 °C - 85 °C, stir until transparent, homogenize at 3000 rpm for 3 - 5 minutes, keep stirring for 30 - 35 minutes, and turn on the cooling water (medium speed) to obtain a mixed solution. (4)Cool the mixed solution obtained in step (3) to below 40 °C, and sequentially add the acne-removing lipid vesicles, skin conditioner, and pH regulator, and stir at 1500 rpm for 15 minutes until all components are evenly mixed. (5)Take a sample to check the color, smell, and uniformity. After passing the initial inspection, filter and discharge the material to remove undissolved or residual substances in the composition to ensure the purity and stability of the essence. Example 3

[0022] An essence composition containing acne-removing lipid vesicles, the ingredient list is shown in Table 1, and it is prepared according to the following steps: (1)Preparation of anti-acne effect liposomes: First, weigh 400 mg of white willow bark extract, 100 mg of pioniin, 600 mg of bletilla striata root extract, 1000 mg of niacinamide and 50 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine; Subsequently, weigh 2000 mg of lecithin and 300 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved; Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 15,000 rpm, and stir for 8 minutes to form a preliminary liposome-encapsulated complex; Then transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanometer level of 100 - 200 nm, ensuring the encapsulation uniformity and high encapsulation efficiency; After that, remove the residual ethanol by low-temperature rotary evaporation, and control the temperature below 40 °C to reduce the potential irritation to the skin; Finally, cool the liposome solution to room temperature and add 2% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation and ensure the stability of the system.

[0023] (2)Weigh other raw material components in the essence according to the formula requirements for standby; (3)Add the humectant, thickener, chelating agent, and preservative to the main emulsifying pot, heat up to 82 °C - 85 °C, stir until dissolved and transparent, homogenize at 3000 rpm for 3 - 5 minutes, keep stirring for 30 - 35 minutes, and turn on the cooling water (medium speed) to obtain a mixed solution; (4)Cool the mixed solution obtained in step (3) to below 40 °C, and sequentially add the anti-acne effect liposomes, skin conditioner, and pH regulator, and stir at 1500 rpm for 15 minutes until each component is evenly mixed; (5)Take a sample to check the color, smell, and uniformity. After the initial inspection is qualified, filter and discharge to remove undissolved or residual substances in the composition to ensure the purity and stability of the essence. Efficacy test and verification:

[0024] 1. Stability test Test sample: Example 1 Testing Method: The composition prepared in Example 1 was subjected to a stability test. The temperature stability test was performed at -15°C, 5°C, 25°C, 37°C, and 48°C. The light stability test involved exposing the sample to sunlight for weeks and months to assess changes in various indicators. The pH value test involved measuring the pH of Example 1 using a glass polar pH meter to ensure it remained within an appropriate range. Viscosity Test: The viscosity of the composition was measured using an instrument such as a Brookfield viscometer to assess its fluidity and stability. The test period was one, two, and three months, during which changes in appearance (color, fading, foreign matter intrusion, separation, precipitation, etc.), aroma, viscosity, and pH were observed.

[0025] The test results are shown in Table 2 below: Time 48℃ 37℃ 25℃ 5℃ -15℃ Light 1 week √ √ √ √ √ √ 2 weeks √ √ √ √ √ √ 3 weeks √ √ √ √ √ √ 1 month √ √ √ √ √ √ 2 months √ √ √ √ √ √ 3 months √ √ √ √ √ √ As shown in Table 2 above, the composition prepared in Example 1 showed no significant changes in color, viscosity, or pH value under different temperature conditions and light exposure within three months, indicating that the composition has good stability.

[0026] 2. Security Testing Test sample: Example 1 patch test Test method: Skin occlusive patch test method The selected area shall not exceed 50mm 2 Use a qualified spot test device with a depth of approximately 1mm. Add the test substance to the spot test device, using approximately 0.020mL-0.025mL (liquid). Apply the test substance and negative control patch to the subject's flexed forearm. Remove the patch after 24 hours. Observe the skin for skin reactions according to the criteria in the table below 30 minutes (after the indentation disappears), 24 hours, and 48 hours after removal of the test substance patch device, and record the results.

[0027] The skin reaction grading standards for the skin occlusion patch test are as follows: Table 4 Skin occlusive patch test results of Example 1 As shown in Table 4, the results of the single closed patch test on human skin show that no adverse skin reaction occurred in 31 people, indicating that the prepared composition is non-irritating and has passed the safety test.

[0028] 3. Evaluation of the anti-acne effect of the composition of Example 1 Test sample: Example 1 Testing Method: This test verified the acne-removing efficacy of the composition of Example 1 by measuring pimple counts and self-assessment in 31 subjects before and after using it. To use: After cleansing your face morning and night, apply an appropriate amount of the composition of Example 1 to your face and gently massage with your fingertips until completely absorbed.

[0029] Test time points: Before using the composition (D0), 14 days after using the composition (D14), after sitting still for 30 minutes in a laboratory at a temperature of 21 ± 1°C and 50 ± 10% RH, the index tests were carried out; (1) Papule counting method The papule counting method is to test the change in the number of papules before using the composition (D0) and 14 days after using the composition (D14). The smaller the value, the fewer the number of papules, and the better the acne treatment effect.

[0030] The test results of papule counting at different time points are as follows Figure 1 shown as follows: Compared with before using the composition of the present invention, after 14 days of using the sample by 31 subjects, the papule count decreased significantly, and the difference before and after use was large. It shows that the test composition has acne treatment efficacy after 14 days of use.

[0031] (2) Self-assessment by subjects Scoring criteria: Questions 1 - 5: (5-point system) 1 point means very disagree, 2 points means disagree, 3 points means neither negative nor positive, 4 points means agree, and 5 points means very agree.

[0032] Degree of agreement statistics: Degree of agreement = [ (Number of people with a score of 4 (agree) + Number of people with a score of 5 (very agree) / Total number of people) ] × 100% The following is the self-assessment result agreement form of 31 subjects as follows: .

Claims

1. An essence composition containing liposomes with acne-removing efficacy, characterized in that, By weight percentage of the composition, it comprises the following raw material components: 2 - 30% acne - treating liposomes; 0.5 - 15% skin conditioner; 5 - 40% humectant; 0.1 - 3% preservative; 0.15 - 10% thickener; 0.05 - 5% chelating agent; 0.01 - 3% pH regulator; The balance is deionized water; Among them, the acne - treating liposomes at least comprise: 1.5 - 2.5% white willow bark extract, 0.3 - 0.7% piperonyloxide, 2 - 4% bletilla striata root extract, 4 - 6% niacinamide, 0.15 - 0.35% oligopeptide - 3, 7 - 12% lecithin and 1 - 2% cholesterol, and the mass ratio of the white willow bark extract, piperonyloxide, bletilla striata root extract, niacinamide, oligopeptide - 3, lecithin, cholesterol is 1:(0.2 - 0.5):(1 - 2):(2 - 3):(0.2 - 1):(4 - 5):(0.5 - 1).

2. The essence liquid composition containing liposomes with acne-removing efficacy according to claim 1, characterized in that, The acne - treating liposomes are prepared by the following process: (1) Take an appropriate amount of deionized water, and successively add 1.5 - 2.5% white willow bark extract, 0.3 - 0.7% piperonyloxide, 2 - 4% bletilla striata root extract, 4 - 6% niacinamide, 0.15 - 0.35% water - soluble component of oligopeptide - 3. After adding each component, stir at a low speed (300 rpm) until completely dissolved and finally form a homogeneous solution. Subsequently, adjust the pH value of the mixed solution to be between 5.0 - 5.8 with a pH regulator; (2) In another clean container, dissolve 7 - 12% lecithin and 1 - 2% cholesterol in a small amount of ethanol or propylene glycol, place it in a water bath at 40 - 45°C, and stir gently until completely dissolved; (3) Slowly pour the solution in step (2) into the mixed solution in step (1), increase the stirring speed to 10000 - 15000 rpm, and continuously stir for 5 - 10 minutes to form a preliminary liposome - encapsulated complex; Transfer the complex to a high - pressure homogenizer, set the homogenization pressure in the range of 5000 - 8000 psi, and homogenize 3 - 5 times to form nanoscale liposomes with a particle size range of 100 - 200 nm; Remove the residual ethanol solvent by low - temperature rotary evaporation, and control the evaporation temperature below 40°C; Slowly cool the liposome solution to room temperature, and add 1 - 2% glycerol as a stabilizer to obtain acne - treating liposomes with a stable system.

3. The preparation method of the essence liquid composition containing acne-removing liposomes according to claim 2, characterized in that, The acne - treating liposomes are prepared according to the following steps: First, weigh 200 mg of white willow bark extract, 50 mg of piperonylic acid, 300 mg of bletilla striata root extract, 500 mg of niacinamide, and 25 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then, adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine to obtain an active ingredient mixture; Subsequently, weigh 1000 mg of lecithin and 150 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved; Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 10,000 rpm, and stir for 5 minutes to form a preliminary liposome-encapsulated complex; Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanoscale of 100 - 200 nm, ensuring uniform encapsulation and a high encapsulation efficiency; After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce potential irritation to the skin; Finally, cool the liposome solution to room temperature and add 1% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation, obtaining a liposome with stable system and acne-removing efficacy.

4. The preparation method of the essence liquid composition containing acne-removing liposomes according to claim 2, characterized in that, The liposome with acne-removing efficacy is prepared according to the following steps: First, weigh 300 mg of white willow bark extract, 75 mg of piperonylic acid, 450 mg of bletilla striata root extract, 750 mg of niacinamide, and 37.5 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then, adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine; Subsequently, weigh 1500 mg of lecithin and 225 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved; Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 15,000 rpm, and stir for 5 minutes to form a preliminary liposome-encapsulated complex; Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanoscale of 100 - 200 nm, ensuring uniform encapsulation and a high encapsulation efficiency; After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce potential irritation to the skin; Finally, cool the liposome solution to room temperature and add 1.5% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation, ensuring the stability of the system.

5. The preparation method of the essence liquid composition containing acne-removing liposomes according to claim 2, characterized in that, The liposome with acne-removing efficacy is prepared according to the following steps: First, weigh 400 mg of white willow bark extract, 100 mg of pioinine, 600 mg of bletilla striata root extract, 1000 mg of niacinamide, and 50 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then, adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine. Subsequently, weigh 2000 mg of lecithin and 300 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved. Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 15,000 rpm, and stir for 8 minutes to form a preliminary liposome-encapsulated complex. Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanometer level of 100 - 200 nm, ensuring the encapsulation uniformity and a high encapsulation efficiency. After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce the potential irritation to the skin. Finally, cool the liposome solution to room temperature and add 2% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation and ensure the stability of the system.

6. The preparation method of the essence liquid composition containing acne-removing liposomes according to claim 2, characterized in that, The acne-removing effect liposome is prepared according to the following steps: First, weigh 400 mg of white willow bark extract, 100 mg of pioinine, 600 mg of bletilla striata root extract, 1000 mg of niacinamide, and 50 mg of oligopeptide, dissolve them in deionized water, and mix well under low-speed stirring at 300 rpm until completely dissolved to form a uniform mixture. Then, adjust the pH value of the solution to 5.0 - 5.8 with lactic acid and arginine. Subsequently, weigh 2000 mg of lecithin and 300 mg of cholesterol in another clean container, dissolve them with a small amount of ethanol, and place them in a water bath at 40 - 45 °C and stir gently until completely dissolved. Then, slowly add the lecithin and cholesterol solution to the above-mentioned active ingredient mixture, increase the stirring speed to 15,000 rpm, and stir for 8 minutes to form a preliminary liposome-encapsulated complex. Next, transfer the complex to a high-pressure homogenizer and homogenize it 3 times within the range of 6,000 psi to make the liposome particle size reach the nanometer level of 100 - 200 nm, ensuring the encapsulation uniformity and a high encapsulation efficiency. After that, remove the residual ethanol by low-temperature rotary evaporation, with the temperature controlled below 40 °C to reduce the potential irritation to the skin. Finally, cool the liposome solution to room temperature and add 2% glycerol as a stabilizer to effectively prevent liposome aggregation and denaturation and ensure the stability of the system.

7. A method for preparing an essence composition containing liposomes with acne-removing efficacy according to any one of claims 1-6, characterized in that, It includes the following steps: Weigh each raw material component according to the formula requirements and set aside. Add the humectant, thickener, chelating agent, and preservative to the main emulsifying pot, heat up to 82 °C - 85 °C, stir until dissolved and transparent, homogenize at 3000 rpm for 3 - 5 minutes, keep stirring for 30 - 35 minutes, and turn on the cooling water. Cool the mixture obtained in step (2) to below 40°C, and sequentially add the anti-acne effect liposomes, skin conditioner, and pH regulator, and stir at 1500 rpm for 15 minutes until the components are evenly mixed; Take a sample to check the color, odor, and uniformity. After passing the initial inspection, filter and discharge to obtain the essence composition containing anti-acne effect liposomes.

8. A skin care product, characterized in that: This skin care product contains the essence composition containing anti-acne effect liposomes described in claims 1-6.

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