A care powder prepared from a plant extract ingredient and a pressed powder prepared therefrom

Abstract

The present application relates to the field of medical materials, in particular to a kind of plant extraction component preparation's nursing powder and the powder cake prepared by it, comprising the following components: active substance A 15-20 parts;Active substance B 30-40 parts;Active substance C 5-12 parts;Genipin crosslinking agent 0.1-0.3 parts;Microcrystalline cellulose 15-20 parts;Filler 10-15 parts.The present application is specially made by coating, plugging and other processes, active substance A, active substance B and active substance C contain different functional active substances, which can prevent functional active substances from being oxidized, lost prematurely, etc.The plant extraction component preparation's nursing powder and the powder cake prepared by it provided by the present application can be used for the nursing powder for preventing pressure ulcers caused by long bed rest, and has the effects of moisture absorption, skin surface pH regulation, antibacterial slow release.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical materials, in particular to a nursing powder prepared from plant extract ingredients and a pressed powder prepared therefrom. BACKGROUND

[0002] Pressed powder is mostly used in the field of cosmetics, and a few are used in infant care. There are not many products for users who have lost the ability to take care of themselves, such as bedridden elderly and bedridden patients. Long-term bedridden people are prone to pressure sores in some areas of the back due to difficulties in turning over, and these pressure sores are mostly caused by problems such as body fluid secretion and bacterial infection. By nursing the back of the user and applying a layer of nursing powder, the skin can be kept dry and bacterial growth can be inhibited, which can greatly prevent and treat pressure sores. Most of the current similar products have the problems of insufficient long-acting and easy oxidation after the pressed powder is applied. This is because during the production process of the pressed powder, the active substances are mostly directly mixed and pressed with the remaining components, resulting in a decrease in long-acting. For example, CN104042505B discloses a pressed powder and a production process thereof, which adds beta-glucan and natural plant ingredients such as rice bran oil, olive fruit oil, grape seed oil, and radix scrophulariae extract. The pressed powder is obtained by mixing and pressing multiple times. SUMMARY

[0003] In order to make up for the above shortcomings, the present application provides a nursing powder prepared from plant extract ingredients and a pressed powder prepared therefrom, which aims to provide a nursing powder that can be used to prevent pressure sores caused by long-term bedridden, and has the effects of moisture absorption, skin surface pH adjustment, and antibacterial slow-release.

[0004] In order to achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0005] A nursing powder prepared from plant extract ingredients, comprising the following components by mass fraction:

[0006] 15-20 parts of active substance A;

[0007] 30-40 parts of active substance B;

[0008] 5-12 parts of active substance C;

[0009] 0.1-0.3 parts of genipin crosslinking agent;

[0010] 15-20 parts of microcrystalline cellulose;

[0011] 10-15 parts of filler;

[0012] The preparation method of the active substance A comprises the following steps by weight fraction:

[0013] Step (a-1): 100 parts of mesoporous silica powder, 3-8 parts of silane coupling agent are added into 5-10% mass fraction of ethanol aqueous solution, after sufficient infiltration, take out, dry, and obtain hydrophobic modified mesoporous silica powder;

[0014] Step (a-2): the modified mesoporous silica powder is immersed in a fat-soluble active substance, after sufficient infiltration under negative pressure, the solid phase is separated, then the solid phase is added into a buffer solution with pH of 5.5-7, soaked for 30-60s, to wash off the fat-soluble active substance and residual ethanol on the surface, the solid phase is separated, freeze-dried, and dispersed, to obtain active substance A;

[0015] The preparation method of the active substance B comprises the following steps:

[0016] Step (b-1): the mesoporous silica powder is immersed in a water-soluble active substance, after sufficient infiltration under negative pressure, the solid phase is separated, then sodium alginate is added, stirred, and separated, to obtain sodium alginate modified mesoporous silica powder;

[0017] Step (b-2): the sodium alginate modified mesoporous silica powder is added into a solidifying agent solution under stirring, the solid phase is separated, and freeze-dried, to obtain active substance B;

[0018] The preparation method of the active substance C comprises the following steps by weight parts:

[0019] Step (c-1): 100 parts of polyacrylic acid sodium powder is completely swelled in 400-500 parts of water, the carboxyl group is activated, then 0.5-1 parts of a peptide anti-aging factor is added, and the reaction is carried out under nitrogen atmosphere, to obtain polyacrylic acid sodium sol;

[0020] Step (c-2): the polyacrylic acid sodium sol is purified by dialysis, concentrated, freeze-dried, and active substance C is obtained.

[0021] The active substance A, the active substance B and the active substance C are prepared in the scheme, each of which contains different functional active substances: the active substance A encapsulates the fat-soluble active substance in the micropores of the hydrophobically modified mesoporous silica powder, the micropores are blocked by the solutes in the buffer solution, when applied to the user, the buffer solution solutes are dissolved by the sweat excreted by the user's body surface or the cell liquid excreted by the wound, at this time, the buffer solution solutes can adjust the pH, improve the comfort of the body surface skin, relieve the pain and inflammation of the wound, and then the fat-soluble active substance in the micropores slowly exudes, plays a sterilization and isolation role, and does not cause the body surface to feel oily; the active substance B is coated with sodium alginate and other water-absorbing polymer substances, and the water-soluble active substance is excreted after the sodium alginate is water-absorbed and swelled, and plays a sterilization and antioxidant effect; the active substance C is a polymer of sodium polyacrylate and polypeptide, after water-absorbed and swelled, due to the fact that the normal metabolism pH of the skin surface is acidic, the peptide anti-aging factor is hydrolyzed and excreted, if there is a wound on the skin surface, the excretion of the pH buffer solution solutes can reduce the pH in the wound healing process, continuously hydrolyze and excrete the peptide anti-aging factor, promote and improve the cell activity, and the swelled sodium polyacrylate can form a barrier to isolate microbial infection. In the scheme, the mesoporous silica is micron grade, and the average particle size is 5-100 μm.

[0022] The combination of the three active substances in the scheme can adapt to various use scenarios of the user, when the body surface is not damaged, the main effect is to absorb moisture, keep the skin dry and comfortable, and adjust the pH of the body surface to prevent the skin from being damaged, inflamed and having sores due to the change of the pH value of the body surface caused by the accumulation of metabolites for a long time; when the body surface is damaged, the effective components in the three active substances are activated, can slowly release the active substance to the wound surface, at the same time, play an isolation and protection effect, and absorb the excreted cell metabolites. The scheme can adjust the dissolution of the active substance according to the amount of body fluid excreted by the user, and has a long-acting and slow-release effect, unlike the conventional formula which directly exposes the active substance.

[0023] As a preferred, the filler is one or more of calcium carbonate powder, zinc oxide powder and white carbon black.

[0024] As a preferred, the silane coupling agent in step (a-1) is KH-550 or KH-560; the fat-soluble active substance is camellia oil.

[0025] As a preferred, the buffer solution in step (a-2) is a phosphate buffer solution.

[0026] As a preferred, the water-soluble active substance in step (b-1) is one or more of rosmarinic acid, dipotassium glycyrrhizinate, asiaticoside, hyaluronic acid, aloe polysaccharide and β-glucan; the amount of added sodium alginate is 3-5% of the mass of the mesoporous silica powder.

[0027] Preferably, the solution of the solidifying agent in step (b-2) is a calcium chloride solution with a mass concentration of 3-10%.

[0028] Preferably, the sodium polyacrylate powder in step (c-1) has a carboxyl density of 2-3 mmol / g; and the peptide anti-aging factor is blue copper peptide GHK-Cu or palmitoyl tripeptide-5.

[0029] Preferably, the process of activating the carboxyl groups in step (c-1) is as follows: 400-500 parts of 2-(N-morpholino)ethanesulfonic acid buffer solution with a pH of 5.5-6 is added, stirred for 10-20 min, then 0.3-0.5 parts of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 0.2-0.4 parts of N-hydroxysuccinimide are added in sequence, and stirred at 25°C for 30 min (active intermediates are generated by activating the carboxyl groups).

[0030] Preferably, the dialysis solution for dialysis purification in step (c-2) is an isotonic solution of inorganic salts including one or more of sodium phosphate, potassium chloride, boric acid, and the dialysis solution has a pH of 7.2-7.4.

[0031] The present application also provides a powder compact prepared from the above-mentioned plant extract component prepared powder.

[0032] The present application has the following advantages:

[0033] 1. In the present application, the prepared powder mainly contains plant extracts, which has low skin irritation and contains various active substances, and the active substances A, B and C contain different functional active substances, which can prevent the oxidation and premature loss of the functional active substances through coating and plugging processes.

[0034] 2. In the present application, the functional active substances are released by the body surface state of the user, such as excessive sweating of the user, and the sweat permeation can slowly promote the release of the active substances, adjust the pH, and have the effects of antibacterial and anti-sore, while absorbing sweat and keeping dry; under the condition of surface wound of the user, the local metabolic cell liquid increases, the pH value changes, and after the release of the functional active substances of the three active substances, they promote each other, have the effects of antibacterial, pH adjustment, blocking and moisture absorption. It is suitable for groups who need to lie in bed for a long time and are difficult to turn over, and can prevent pressure sores. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present application will be described below in a clear and complete manner. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application. Example 1

[0036] A care powder prepared from plant extract ingredients, comprising the following components in mass parts:

[0037] Active substance A 18 parts;

[0038] Active substance B 35 parts;

[0039] Active substance C 8 parts;

[0040] Genipin crosslinking agent 0.2 parts;

[0041] Microcrystalline cellulose 17 parts;

[0042] Filler 12 parts, calcium carbonate powder, zinc oxide powder, white carbon black in a mass ratio of 1:1:1;

[0043] The preparation method of the active substance A, comprising the following steps in parts by weight:

[0044] Step (a-1): 100 parts of mesoporous silica powder and 5 parts of silane coupling agent KH-550 are added to an ethanol aqueous solution with a mass fraction of 8%, and after sufficient soaking, the solid phase is separated, and then the solid phase is added to a potassium dihydrogen phosphate and dipotassium hydrogen phosphate buffer solution with a pH of 5.5, soaked for 50 s, and the surface camellia oil and residual ethanol are washed away, the solid phase is separated, freeze-dried, and dispersed to obtain the active substance A;

[0045] Step (a-2): The modified mesoporous silica powder is immersed in camellia oil, and after sufficient soaking under negative pressure, the solid phase is separated, and then the solid phase is added to a potassium dihydrogen phosphate and dipotassium hydrogen phosphate buffer solution with a pH of 5.5, soaked for 50 s, and the surface camellia oil and residual ethanol are washed away, the solid phase is separated, freeze-dried, and dispersed to obtain the active substance A;

[0046] The preparation method of the active substance B, comprising the following steps:

[0047] Step (b-1): The mesoporous silica powder is immersed in water-soluble active substances, and after sufficient soaking under negative pressure, the solid phase is separated, and then sodium alginate is added, stirred, and separated to obtain sodium alginate modified mesoporous silica powder; the water-soluble active substances are rosmarinic acid, hyaluronic acid, and β-glucan in a mass ratio of 1:1:1; the amount of added sodium alginate is 4% of the mass of the mesoporous silica powder;

[0048] Step (b-2): The sodium alginate modified mesoporous silica powder is added to a calcium chloride solution with a mass concentration of 5% under stirring, the solid phase is separated, and freeze-dried to obtain the active substance B;

[0049] The preparation method of the active substance C, comprising the following steps in parts by weight:

[0050] Step (c-1): 100 parts of sodium polyacrylate powder is completely swelled in 500 parts of water, the carboxyl group is activated, then 0.8 parts of peptide anti-aging factor is added, and the reaction is carried out under nitrogen atmosphere, to obtain sodium polyacrylate sol; the carboxyl group density of the sodium polyacrylate powder is 2 mmol / g; the peptide anti-aging factor is blue copper peptide GHK-Cu; the process of activating the carboxyl group is: 500 parts of 2-(N-morpholino) ethanesulfonic acid buffer solution with pH of 5.5 is added, stirring for 15 min, then 0.4 parts of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 0.3 parts of N-hydroxysuccinimide are added in sequence, and stirring is carried out at 25℃ for 30 min;

[0051] Step (c-2): the sodium polyacrylate sol is purified by dialysis, concentrated, and freeze-dried to obtain active substance C; the dialysis liquid for purification is an isotonic solution of inorganic salts including sodium phosphate, potassium chloride, boric acid, and the dialysis liquid has pH of 7.4. Example 2

[0052] A care powder prepared from a plant extract ingredient, comprising the following components in parts by mass:

[0053] Active substance A 15 parts;

[0054] Active substance B 30 parts;

[0055] Active substance C 5 parts;

[0056] Genipin crosslinking agent 0.1 part;

[0057] Microcrystalline cellulose 15 parts;

[0058] Filler 10 parts, calcium carbonate powder, zinc oxide powder, and white carbon black in a mass ratio of 1:1:1;

[0059] The preparation method of the active substance A comprises the following steps in parts by mass:

[0060] Step (a-1): 100 parts of mesoporous silica powder and 3 parts of silane coupling agent KH-550 are added to an ethanol aqueous solution with a mass fraction of 5%, the mixture is thoroughly soaked, then the mixture is taken out and dried, to obtain hydrophobically modified mesoporous silica powder;

[0061] Step (a-2): the modified mesoporous silica powder is immersed in camellia oil, the solid phase is separated after thorough soaking under negative pressure, then the solid phase is added to a buffer solution of potassium dihydrogen phosphate and dipotassium hydrogen phosphate with pH of 6, and the solid phase is soaked for 40 s, to wash away the camellia oil and residual ethanol on the surface, the solid phase is separated, freeze-dried, and dispersed, to obtain active substance A;

[0062] The preparation method of the active substance B comprises the following steps:

[0063] Step (b-1): immerse the mesoporous silica powder into the water-soluble active substance, separate the solid phase after sufficient infiltration under negative pressure, then add sodium alginate, stir, separate, and obtain the sodium alginate modified mesoporous silica powder; the water-soluble active substance is dipotassium glycyrrhizinate, aloe polysaccharide and beta-glucan in a mass ratio of 1:1:1; the amount of sodium alginate added is 3% of the mass of the mesoporous silica powder;

[0064] Step (b-2): add the sodium alginate modified mesoporous silica powder to a 3% mass concentration calcium chloride solution under stirring, separate the solid phase, and freeze-dry to obtain the active substance B;

[0065] The preparation method of the active substance C includes the following steps in terms of weight parts:

[0066] Step (c-1): completely swell 100 parts of polyacrylic acid sodium powder in 400 parts of water, activate the carboxyl group, then add 0.5 parts of a peptide anti-aging factor, and fully react under a nitrogen atmosphere to obtain a polyacrylic acid sodium sol; the carboxyl group density of the polyacrylic acid sodium powder is 2.5 mmol / g; the peptide anti-aging factor is palmitoyl tripeptide-5; the process of activating the carboxyl group is: add 400 parts of 2-(N-morpholino) ethanesulfonic acid buffer solution with a pH of 6, stir for 20 min, then sequentially add 0.3 parts of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 0.2 parts of N-hydroxysuccinimide, and stir at 25°C for 30 min;

[0067] Step (c-2): dialysis purify the polyacrylic acid sodium sol, concentrate, and freeze-dry to obtain the active substance C; the dialysis liquid for dialysis purification is an isotonic solution of inorganic salts including sodium phosphate, potassium chloride, boric acid, and the pH of the dialysis liquid is 7.3.

[0068] Comparative Example 1

[0069] The difference from Example 1 is that the active substance is not subjected to adsorption, coating, plugging, etc.

[0070] A plant extract ingredient prepared care powder, including the following components in terms of mass parts:

[0071] Mesoporous silica 50 parts;

[0072] Camellia oil 0.5 parts;

[0073] Rosmarinic acid, hyaluronic acid, beta-glucan 1 part;

[0074] Polyacrylic acid sodium 4.8 parts;

[0075] Blue copper peptide GHK-Cu 0.3 parts

[0076] Genipin crosslinking agent 0.1 parts;

[0077] Microcrystalline cellulose 15 parts;

[0078] Filler 10 parts, mass ratio of calcium carbonate powder, zinc oxide powder, white carbon black 1:1:1;

[0079] Comparative Example 2

[0080] Different from Example 1, the active substance is not blocked, coated, etc.

[0081] A care powder prepared from a plant extract ingredient, comprising the following components in parts by mass:

[0082] Active substance A 18 parts;

[0083] Active substance B 35 parts;

[0084] Active substance C 8 parts;

[0085] Genipin crosslinking agent 0.2 parts;

[0086] Microcrystalline cellulose 17 parts;

[0087] Filler 12 parts, mass ratio of calcium carbonate powder, zinc oxide powder, white carbon black 1:1:1;

[0088] The preparation method of the active substance A, comprising the following steps in parts by weight:

[0089] Step (a-1): 100 parts of mesoporous silica powder and 5 parts of silane coupling agent KH-550 are added to an ethanol aqueous solution with a mass fraction of 8%, and after sufficient infiltration, they are taken out and dried to obtain hydrophobically modified mesoporous silica powder;

[0090] Step (a-2): The modified mesoporous silica powder is immersed in camellia oil, and after sufficient infiltration under negative pressure, the solid phase is separated, freeze-dried, and dispersed to obtain the active substance A;

[0091] The preparation method of the active substance B, comprising the following steps:

[0092] The mesoporous silica powder is immersed in a water-soluble active substance, and after sufficient infiltration under negative pressure, the solid phase is separated, freeze-dried to obtain the active substance B; the water-soluble active substance is a mixture of rosmarinic acid, hyaluronic acid and β-glucan in a mass ratio of 1:1:1; the amount of added sodium alginate is 4% of the mass of the mesoporous silica powder;

[0093] The preparation method of the active substance C, comprising the following steps in parts by weight:

[0094] Step (c-1): 100 parts of sodium polyacrylate powder is completely swelled in 500 parts of water, then 0.8 parts of peptide anti-aging factor is added, and the reaction is carried out under nitrogen atmosphere, to obtain sodium polyacrylate sol; the carboxyl density of the sodium polyacrylate powder is 2 mmol / g; the peptide anti-aging factor is blue copper peptide GHK-Cu;

[0095] Step (c-2): the sodium polyacrylate sol is purified by dialysis, concentrated, and freeze-dried to obtain active substance C; the dialysis solution for purification is an isotonic solution of inorganic salts including sodium phosphate, potassium chloride, boric acid, and the pH of the dialysis solution is 7.4.

[0096] Comparative Example 3

[0097] The difference from Example 1 is that the active substance A, the active substance B, and the active substance C are excessive.

[0098] A care powder prepared from a plant extract ingredient, comprising the following components in parts by mass:

[0099] Active substance A 30 parts;

[0100] Active substance B 45 parts;

[0101] Active substance C 20 parts;

[0102] Genipin crosslinking agent 0.2 parts;

[0103] Microcrystalline cellulose 17 parts;

[0104] Filler 12 parts, calcium carbonate powder, zinc oxide powder, and white carbon black in a mass ratio of 1:1:1;

[0105] The preparation method of the active substance A, comprising the following steps in parts by weight:

[0106] Step (a-1): 100 parts of mesoporous silica powder and 5 parts of silane coupling agent KH-550 are added to an ethanol aqueous solution with a mass fraction of 8%, and after being fully immersed, the mesoporous silica powder is taken out and dried to obtain hydrophobically modified mesoporous silica powder;

[0107] Step (a-2): the modified mesoporous silica powder is immersed in camellia oil, and after being fully immersed under negative pressure, the solid phase is separated, then the solid phase is added to a potassium dihydrogen phosphate and dipotassium hydrogen phosphate buffer solution with a pH of 5.5, soaked for 50 s, and the camellia oil and residual ethanol on the surface are washed away, the solid phase is separated, freeze-dried, and dispersed to obtain the active substance A;

[0108] The preparation method of the active substance B, comprising the following steps:

[0109] Step (b-1): immerse the mesoporous silica powder into the water-soluble active substance, separate the solid phase after sufficient infiltration under negative pressure, then add sodium alginate, stir, separate, and obtain the sodium alginate modified mesoporous silica powder; the water-soluble active substance is rosmarinic acid, hyaluronic acid and beta-glucan in a mass ratio of 1:1:1; the amount of added sodium alginate is 4% of the mass of the mesoporous silica powder;

[0110] Step (b-2): add the sodium alginate modified mesoporous silica powder to a 5% calcium chloride solution under stirring, separate the solid phase, and freeze-dry to obtain the active substance B;

[0111] The preparation method of the active substance C includes the following steps in terms of weight parts:

[0112] Step (c-1): completely swell 100 parts of sodium polyacrylate powder in 500 parts of water, activate the carboxyl group, then add 0.8 parts of a peptide anti-aging factor, and fully react under a nitrogen atmosphere to obtain a sodium polyacrylate sol; the carboxyl group density of the sodium polyacrylate powder is 2 mmol / g; the peptide anti-aging factor is blue copper peptide GHK-Cu; the process of activating the carboxyl group is: add 500 parts of 2-(N-morpholino) ethanesulfonic acid buffer solution with a pH of 5.5, stir for 15 min, then sequentially add 0.4 parts of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and 0.3 parts of N-hydroxysuccinimide, and stir at 25°C for 30 min;

[0113] Step (c-2): dialysis purify the sodium polyacrylate sol, concentrate, and freeze-dry to obtain the active substance C; the dialysis liquid for dialysis purification is an isotonic solution of inorganic salts including sodium phosphate, potassium chloride, and boric acid, and the pH of the dialysis liquid is 7.4.

[0114] Performance test:

[0115] Disperse 10 g of sterilized proteose peptone, 5 g of sodium chloride, 2 g of glucose, 1 g of sodium lactate, 0.5 g of L-glutamine, 1 g of bovine serum albumin, and 1 g of Tween 80 in 1 L of deionized water, adjust the pH to 6.5 with a phosphate buffer, and use it as a bacterial culture solution. Staphylococcus aureus is inoculated and cultured at 37°C for 10 h to obtain a bacterial culture solution;

[0116] Release effect detection: take 5 g of the care powder prepared in Example 1-2 and Comparative Example 1-3, uniformly spread it on the sterile culture medium, spray 5 g of the bacterial culture solution, continue to culture at 37°C for 24 h; continue to spray 5 g of the bacterial culture solution, continue to culture at 37°C for 24 h, repeat 2 times, record the number of bacteria each time, and test the antibacterial effect;

[0117] Molding and use effect detection: 20 g of the care powder prepared in Example 1-2 and Comparative Example 1-3 was taken and pressed into a powder cake, and the powder cake was observed for cracking; the powder was taken from the powder cake with a powder puff, and the powder was applied to a 100 cm 2 silica gel plate in the same number and direction, the powder adhesion uniformity was observed, the adhesion weight m1 was measured, and then the powder layer was placed in an air environment with a relative humidity of 90% for 60 min, and whether the powder layer was agglomerated and the weight of the powder layer after water absorption m2 was measured.

[0118] The test results are shown in Table 1.

[0119] Table 1

[0120]

[0121] From the test results, it can be seen that Examples 1 and 2 have advantages in antibacterial effect over Comparative Examples 1 and 2, which indicates that the care powder prepared from the plant extract component prepared according to the present scheme has better slow-release effect. Although Comparative Example 3 also has good slow-release effect, its molding and use effect is poor, and the reason may be that the active substance A, the active substance B, and the active substance C are excessive in Comparative Example 3, resulting in insufficient proportion of the genipin crosslinking agent and microcrystalline cellulose as the binder, thereby causing the molding effect to be poor. In addition, the surface of the active substance B and the active substance C is elastic due to the high molecular polymer, and dry pressing molding may not be effective, and since the water absorption amount is large, the powder layer is agglomerated after being placed in an air environment with a relative humidity of 90% for 60 min, which may be due to the excessive density of the same active substance per unit area, resulting in agglomeration after water absorption. The molding effect of Comparative Examples 1 and 2 is good, which may be due to a small amount of liquid phase substances such as camellia oil not being encapsulated in the solid phase to become a binder, but also due to these substances causing the smearing uniformity to be poor and the adhesion amount to be reduced.

[0122] Finally, it should be noted that: the above only describes the preferred embodiments of the present application and is not intended to limit the present application, although the present application has been described in detail with reference to the foregoing embodiments, and for those skilled in the art, the technical solutions described in the foregoing embodiments can be modified, or some technical features can be replaced by equivalents, and any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A nursing powder prepared from plant extracts, characterized in that, By weight, it includes the following components: Active ingredient A: 15-20 parts; Active substance B 30-40 parts; Active substance C: 5-12 parts; Genipin crosslinking agent 0.1-0.3 parts; 15-20 parts of microcrystalline cellulose; 10-15 parts of filler; The filler is one or more of calcium carbonate powder, zinc oxide powder, and precipitated silica. The preparation method of the active substance A, by weight, includes the following steps: Step (a-1): Add 100 parts of mesoporous silica powder and 3-8 parts of silane coupling agent to an ethanol aqueous solution with a mass fraction of 5-10%. After fully impregnating, remove and dry to obtain hydrophobic modified mesoporous silica powder. Step (a-2): Immerse the modified mesoporous silica powder in the lipophilic active material. After fully wetting under negative pressure, separate the solid phase. Then add the solid phase to a buffer solution with a pH of 5.5-7, soak for 30-60 seconds, separate the solid phase, freeze dry, and disperse to obtain active material A. The fat-soluble active ingredient is camellia oil; The preparation method of the active substance B includes the following steps: Step (b-1): Immerse the mesoporous silica powder in water-soluble active material, fully wet it under negative pressure, separate the solid phase, then add sodium alginate, stir, separate, and obtain sodium alginate modified mesoporous silica powder. The water-soluble active ingredient is one or more of the following: rosmarinic acid, dipotassium glycyrrhizate, asiaticoside, hyaluronic acid, aloe polysaccharide, and β-glucan. Step (b-2): Sodium alginate modified mesoporous silica powder is added to the curing agent solution under stirring, the solid phase is separated, and the solution is freeze-dried to obtain active substance B; The curing agent solution is a calcium chloride solution with a mass concentration of 3-10%; The preparation method of the active substance C, by weight, includes the following steps: Step (c-1): 100 parts of sodium polyacrylate powder are completely swollen in 400-500 parts of water to activate the carboxyl groups. Then, 0.5-1 parts of peptide anti-aging factor are added and reacted fully under a nitrogen atmosphere to obtain sodium polyacrylate sol. The peptide anti-aging factor is blue copper peptide GHK-Cu or palmitoyl tripeptide-5. Step (c-2): The sodium polyacrylate sol was purified by dialysis, concentrated, and then freeze-dried to obtain active substance C.

2. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The silane coupling agent mentioned in step (a-1) is KH-550 or KH-560.

3. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The buffer solution described in step (a-2) is a phosphate buffer solution.

4. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The amount of sodium alginate added in step (b-1) is 3-5% of the mass of the mesoporous silica powder.

5. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The carboxyl density of the sodium polyacrylate powder described in step (c-1) is 2-3 mmol / g.

6. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The process of activating the carboxyl group in step (c-1) is as follows: add 400-500 parts of 2-(N-morpholino)ethanesulfonic acid buffer solution with pH 5.5-6, stir for 10-20 min, then add 0.3-0.5 parts of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 0.2-0.4 parts of N-hydroxysuccinimide, and stir at 25°C for 30 min.

7. The nursing powder prepared from the plant extracts as described in claim 1, characterized in that, The dialysate used for dialysis purification in step (c-2) is an isotonic solution containing one or more inorganic salts, including sodium phosphate, potassium chloride, and boric acid, with a pH of 7.2-7.

4.

8. A pressed powder comprising the nursing powder as described in any one of claims 1-7.

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