Medical dressing for cesarean wounds and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medical dressing for cesarean wounds and a preparation method of the medical dressing. The invention relates to a preparation method of an anti-aging agent. The medical dressing for the cesarean wounds is prepared from the following raw materials: 0.3 to 0.5 percent of bitter summer squash extract, 1 to 2 percent of hyaluronic acid modified graphene oxide, 0.05 to 0.1 percent of recombinant III type humanized collagen, 0.05 to 0.1 percent of antibacterial peptide LL-37, 0.03 to 0.08 percent of acetyl mandelic acid, 5 to 10 percent of polyvinyl alcohol, 1 to 5 percent of hydroxymethyl cellulose, 0.1 to 0.5 percent of xanthan gum, 0.5 to 1.5 percent of glycerol and the balance of distilled water. The medical dressing can accelerate the blood coagulation speed, inhibit wound fibrosis, reduce scar hyperplasia and improve the wound healing speed and quality.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a medical dressing for cesarean section wounds and a preparation method thereof. Background Art

[0002] Cesarean section is an important operation in the field of obstetrics. It refers to the process of removing the fetus by surgically cutting the abdominal wall and uterus of the mother. At present, cesarean section has become an effective means to solve difficult labor and certain obstetric complications, and to save the lives of mothers and babies. With the continuous increase in the cesarean section rate, the main complications after cesarean section are incision dehiscence, infection, fat liquefaction and other factors that cause incision non-healing or long healing period. This is especially prominent in obese, anemic or elderly mothers. In addition, the quality of incision healing is also particularly important for mothers. Poor healing quality may cause uterine scarring, which in turn affects subsequent pregnancy and has become a thorny problem for obstetricians. However, there are currently no cesarean section wound healing materials specifically for this specific group of pregnant women.

[0003] Hydrogel dressings, a novel material developed in recent years, are an ideal choice for cesarean section wound healing. Compared to traditional wound dressings, hydrogel dressings offer significant advantages: First, they exhibit high water absorption and swelling properties, maintaining a moist microenvironment within the wound site. Second, their toughness and elasticity allow them to be fixed within irregular wounds, acting as a mechanical barrier to protect them from bacterial infection and effectively promoting the repair and regeneration of skin tissue. Third, hydrogels can also serve as a delivery system for various drugs, and the incorporation of bioactive substances can synergistically accelerate the wound healing process. Zucchini extract, a natural ingredient extracted from the fruit or seeds of the zucchini plant (Cucurbitaceae), is rich in various bioactive substances and has demonstrated potential health benefits in both traditional medicine and modern research, making it a current research hotspot.

[0004] With the rapid development of modern science and technology, functional hydrogel dressings are becoming increasingly diversified. It is of great significance to develop special hydrogel dressings to meet the special needs of cesarean section wounds. Summary of the Invention

[0005] In order to overcome the shortcomings of the existing technology, one of the purposes of the present invention is to provide a medical dressing for cesarean section wounds, which can accelerate blood coagulation, inhibit wound fibrosis, reduce scar hyperplasia, and improve the speed and quality of wound healing.

[0006] A second object of the present invention is to provide a method for preparing a medical dressing for cesarean section wounds. The preparation method is simple and easy to operate.

[0007] One of the purposes of the present invention is achieved by the following technical solution:

[0008] The invention discloses a medical dressing for cesarean section wounds. The medical dressing for cesarean section wounds comprises the following raw materials, measured in percentage by mass: 0.3-0.5% of bitter zucchini extract, 1-2% of hyaluronic acid-modified graphene oxide, 0.05-0.1% of recombinant type III humanized collagen, 0.05-0.1% of antimicrobial peptide LL-37, 0.03-0.08% of acetylmandelic acid, 5-10% of polyvinyl alcohol, 1-5% of hydroxymethyl cellulose, 0.1-0.5% of xanthan gum, 0.5-1.5% of glycerol, and the balance being distilled water.

[0009] Furthermore, the preparation steps of the bitter zucchini extract are as follows:

[0010] a bitter zucchini pulp was dried, crushed, and then 6-10 times the amount of water was added and boiled, filtered to obtain a first residue and a first filtrate; 6-10 times the amount of water was added to the first residue and boiled, filtered a second time to obtain a second residue and a second filtrate;

[0011] b. The first filtrate and the second filtrate were combined and concentrated to obtain an extract. An ethanol aqueous solution was added to the extract for extraction, and then centrifuged to obtain a supernatant, which was concentrated and dried to obtain a bitter zucchini extract.

[0012] Furthermore, in step a, the two decoction times are both 2-3 hours.

[0013] Furthermore, in step b, the amount of the ethanol aqueous solution added is 8-10 times that of the extract; the extraction temperature is 45-60° C., and the extraction time is 2-3 hours.

[0014] Furthermore, the preparation steps of the hyaluronic acid-modified graphene oxide are as follows:

[0015] S1. Graphene oxide is dispersed in water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added, the pH is adjusted, and then ethylenediamine hydrochloride and 4-dimethylaminopyridine are added to react. The reaction solution after the reaction is filtered, and the solid is collected, washed, and dried to obtain pretreated graphene oxide;

[0016] S2. Add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to the aqueous solution of hyaluronic acid, adjust the pH, and then add pretreated graphene oxide to react. After terminating the reaction, the reaction solution is dialyzed and freeze-dried to obtain hyaluronic acid-modified graphene oxide.

[0017] Furthermore, in step S1, the mass ratio of graphene oxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, ethylenediamine hydrochloride and 4-dimethylaminopyridine is 1:(5-8):(10-15):(8-10):(4.5-5.5); the pH is adjusted to 5-5.5; and the reaction time is 24-28h.

[0018] Furthermore, in step S2, the mass ratio of hyaluronic acid, pretreated graphene oxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide is 1:(2-4):(5-8):(10-15); the pH is adjusted to 5-5.5; and the reaction time is 30-35 hours.

[0019] Furthermore, the molecular weight of the hyaluronic acid in step S2 is 50-200 kDa.

[0020] The second object of the present invention is achieved by adopting the following technical solution:

[0021] The preparation method of the medical dressing for cesarean section wounds comprises the following steps:

[0022] (1) adding polyvinyl alcohol to water accounting for one third of the total amount, heating and stirring, cooling after dissolving, and then adding hydroxymethyl cellulose, xanthan gum, antimicrobial peptide LL-37 and glycerol and stirring thoroughly to obtain a mixture 1;

[0023] (2) adding distilled water accounting for one third of the total amount to the bitter zucchini extract and the hyaluronic acid-modified graphene oxide and stirring thoroughly to obtain a mixture 2;

[0024] (3) adding recombinant humanized type III collagen and acetylmandelic acid to distilled water accounting for one third of the total amount and stirring thoroughly to obtain mixture 3;

[0025] (4) Adding mixture 2 and mixture 3 to mixture 1 and stirring thoroughly, and sterilizing by irradiation to obtain a medical dressing for cesarean section wounds.

[0026] Furthermore, the temperature of the heating and stirring in step (1) is 90-100°C; after dissolution, the temperature is lowered to 45-50°C.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The present invention provides a medical dressing for cesarean section wounds. This dressing contains a bitter zucchini extract and hyaluronic acid-modified graphene oxide. The combination of these two ingredients not only improves the stability of the bitter zucchini extract but also effectively promotes red blood cell aggregation and blood coagulation, significantly promoting wound healing. Furthermore, the dressing also contains recombinant humanized type III collagen and acetylmandelic acid, which can inhibit wound fibrosis, reduce scar hyperplasia, and improve wound healing.

[0029] 2. The hyaluronic acid-modified graphene oxide in the medical dressing of the present invention can adsorb various active substances in the bitter zucchini extract, thereby improving the stability of the bitter zucchini extract. Specifically, the hyaluronic acid can adsorb the hydrophilic active substances in the bitter zucchini extract, while the graphene oxide can adsorb flavonoids and various trace elements in the bitter zucchini extract through π-π stacking.

[0030] 3. The present invention provides a method for preparing a medical dressing for cesarean section wounds. The preparation method is simple and can meet the needs of clinical practice. DETAILED DESCRIPTION

[0031] The following describes the embodiments of the present invention through specific examples. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments, and the details in this specification may be modified or altered based on different viewpoints and applications without departing from the spirit of the present invention.

[0032] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0033] When numerical ranges are given in the examples, it should be understood that, unless otherwise specified herein, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs.

[0034] The molecular weight of the hyaluronic acid in the present invention is 5-20 kDa; the recombinant humanized type III collagen was purchased from Henan Guoxin Biotechnology Co., Ltd.

[0035] Example 1

[0036] A medical dressing for cesarean section wounds, comprising the following raw materials, measured by mass percentage: 0.5% bitter zucchini extract, 2% hyaluronic acid-modified graphene oxide, 0.1% recombinant type III humanized collagen, 0.1% antimicrobial peptide LL-37 (CAS No.: 597562-32-8), 0.08% acetylmandelic acid, 10% polyvinyl alcohol, 5% hydroxymethyl cellulose, 0.5% xanthan gum, 1.5% glycerol, and the balance being distilled water;

[0037] The preparation steps of the bitter zucchini extract are as follows:

[0038] a. The bitter zucchini pulp was dried, crushed, ground, passed through a 50-mesh sieve, added 8 times the amount of water and boiled for 2.5h, filtered to obtain a first residue and a first filtrate; to the first residue was added 8 times the amount of water and boiled for 2.5h, filtered, and a second residue and a second filtrate were obtained;

[0039] b. The first filtrate and the second filtrate were combined and concentrated to a relative density of 1.2 to obtain an extract; 9 times the amount of ethanol aqueous solution (mass concentration of 65%) was added to the extract, extracted at 50°C for 2.5 hours, and centrifuged to obtain a supernatant; the supernatant was concentrated and dried to obtain a bitter zucchini extract.

[0040] The preparation steps of the hyaluronic acid-modified graphene oxide are as follows:

[0041] S1. Graphene oxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC hydrochloride), N-hydroxysuccinimide (NHS), ethylenediamine hydrochloride, and 4-dimethylaminopyridine (DMAP) were weighed in a mass ratio of 1:7:12:9:5, respectively. The graphene oxide was then dispersed in distilled water, EDC hydrochloride and NHS were added, the pH of the solution was adjusted to 5.2, and ethylenediamine hydrochloride and DMAP were then added. The mixture was reacted at room temperature for 26 hours. The reaction solution was filtered, and the solid was collected, washed, and dried to obtain pretreated graphene oxide.

[0042] S2. Hyaluronic acid, pretreated graphene oxide, EDC hydrochloride, and NHS were weighed in a mass ratio of 1:3:6:12. Hyaluronic acid was then dissolved in water, and EDC hydrochloride and NHS were added. The pH of the solution was adjusted to 5.2, and the pretreated graphene oxide was added. The reaction was allowed to react at room temperature for 32 hours. The pH of the solution was adjusted to 7.3 to terminate the reaction. The reaction solution was dialyzed for 4 days and then freeze-dried to obtain hyaluronic acid-modified graphene oxide.

[0043] This embodiment also provides a method for preparing the above-mentioned medical dressing for cesarean section wounds, comprising the following steps:

[0044] (1) adding polyvinyl alcohol to distilled water accounting for one third of the total amount, heating to 95° C. and stirring thoroughly to dissolve, then cooling to 45° C. and adding hydroxymethyl cellulose, xanthan gum, antimicrobial peptide LL-37, and glycerol, and continuing to stir, and cooling to room temperature to obtain a mixture 1;

[0045] (2) adding distilled water accounting for one third of the total amount to the bitter zucchini extract and the hyaluronic acid-modified graphene oxide and stirring thoroughly to obtain a mixture 2;

[0046] (3) adding recombinant humanized type III collagen and acetylmandelic acid to distilled water accounting for one third of the total amount and stirring thoroughly to obtain mixture 3;

[0047] (4) Adding mixture 2 and mixture 3 to mixture 1 and stirring thoroughly until the mixture is uniform, and sterilizing by irradiation to obtain a medical dressing for cesarean section wounds.

[0048] Example 2

[0049] A medical dressing for cesarean section wounds, comprising the following raw materials, calculated by mass percentage: 0.3% bitter zucchini extract, 1% hyaluronic acid-modified graphene oxide, 0.05% recombinant type III humanized collagen, 0.05% antimicrobial peptide LL-37, 0.03% acetylmandelic acid, 5% polyvinyl alcohol, 1% hydroxymethyl cellulose, 0.1% xanthan gum, 0.5% glycerol, and the balance being distilled water;

[0050] The preparation steps of the bitter zucchini extract are as follows:

[0051] a. The bitter zucchini pulp was dried, crushed, ground, passed through a 50-mesh sieve, added 6 times the amount of water and boiled for 2h, filtered to obtain a first residue and a first filtrate; to the first residue was added 6 times the amount of water and boiled for 2h, filtered, and obtained a second residue and a second filtrate;

[0052] b. The first filtrate and the second filtrate were combined and concentrated to a relative density of 1.2 to obtain an extract; 8 times the amount of ethanol aqueous solution (mass concentration of 65%) was added to the extract, extracted at 45°C for 2 hours, and centrifuged to obtain a supernatant; the supernatant was concentrated and dried to obtain a bitter zucchini extract.

[0053] The preparation steps of the hyaluronic acid-modified graphene oxide are as follows:

[0054] S1. Graphene oxide, EDC hydrochloride, NHS, ethylenediamine hydrochloride, and DMAP were weighed in a mass ratio of 1:5:10:8:4.5, respectively. The graphene oxide was then dispersed in distilled water, EDC hydrochloride and NHS were added, the pH of the solution was adjusted to 5, and ethylenediamine hydrochloride and DMAP were then added. The mixture was reacted at room temperature for 24 hours, and the reaction solution was filtered, washed, and dried to obtain pretreated graphene oxide.

[0055] S2. Hyaluronic acid, pretreated graphene oxide, EDC hydrochloride, and NHS were weighed in a mass ratio of 1:2:5:10. Hyaluronic acid was then dissolved in water, and EDC hydrochloride and NHS were added. The pH of the solution was adjusted to 5.0. The pretreated graphene oxide was then added and reacted at room temperature for 30 hours. The pH of the solution was adjusted to 7.0 to terminate the reaction. The reaction solution was dialyzed for 3 days and then freeze-dried to obtain hyaluronic acid-modified graphene oxide.

[0056] This embodiment also provides a method for preparing the above-mentioned medical dressing for cesarean section wounds, comprising the following steps:

[0057] (1) adding polyvinyl alcohol to distilled water accounting for one third of the total amount, heating to 90° C. and stirring thoroughly to dissolve, then cooling to 45° C. and adding hydroxymethyl cellulose, xanthan gum, antimicrobial peptide LL-37, and glycerol, and continuing to stir, and cooling to room temperature to obtain a mixture 1;

[0058] (2) adding distilled water accounting for one third of the total amount to the bitter zucchini extract and the hyaluronic acid-modified graphene oxide and stirring thoroughly to obtain a mixture 2;

[0059] (3) adding recombinant humanized type III collagen and acetylmandelic acid to distilled water accounting for one third of the total amount and stirring thoroughly to obtain mixture 3;

[0060] (4) Adding mixture 2 and mixture 3 to mixture 1 and stirring thoroughly until the mixture is uniform, and sterilizing by irradiation to obtain a medical dressing for cesarean section wounds.

[0061] Example 3

[0062] A medical dressing for cesarean section wounds, comprising the following raw materials, calculated by mass percentage: 0.4% bitter zucchini extract, 1.5% hyaluronic acid-modified graphene oxide, 0.7% recombinant type III humanized collagen, 0.075% antimicrobial peptide LL-37, 0.05% acetylmandelic acid, 7% polyvinyl alcohol, 3% hydroxymethyl cellulose, 0.3% xanthan gum, 1% glycerol, and the balance being distilled water;

[0063] The preparation steps of the bitter zucchini extract are as follows:

[0064] a. The bitter zucchini pulp was dried, crushed, ground, passed through a 50-mesh sieve, added 10 times the amount of water and boiled for 3h, filtered to obtain a first residue and a first filtrate; to the first residue was added 10 times the amount of water and boiled for 3h, filtered, and obtained a second residue and a second filtrate;

[0065] b. The first filtrate and the second filtrate were combined and concentrated to a relative density of 1.2 to obtain an extract; 10 times the amount of ethanol aqueous solution (mass concentration of 65%) was added to the extract, extracted at 60°C for 3 hours, and centrifuged to obtain a supernatant; the supernatant was concentrated and dried to obtain a bitter zucchini extract.

[0066] The preparation steps of the hyaluronic acid-modified graphene oxide are as follows:

[0067] S1. Graphene oxide, EDC hydrochloride), NHS, ethylenediamine hydrochloride, and DMAP were weighed in a mass ratio of 1:8:15:10:5.5, respectively. The graphene oxide was then dispersed in distilled water, EDC hydrochloride and NHS were added, the pH of the solution was adjusted to 5.5, and then ethylenediamine hydrochloride and DMAP were added. The mixture was reacted at room temperature for 28 hours. The reaction solution was filtered, and the solid was collected, washed, and dried to obtain pretreated graphene oxide.

[0068] S2. Hyaluronic acid, pretreated graphene oxide, EDC hydrochloride, and NHS were weighed in a mass ratio of 1:4:8:15. Hyaluronic acid was then dissolved in water, and EDC hydrochloride and NHS were added. The pH of the solution was adjusted to 5.5, and the pretreated graphene oxide was added. The reaction was allowed to react at room temperature for 35 h. The pH of the solution was adjusted to 7.5 to terminate the reaction. The reaction solution was dialyzed for 5 days and then freeze-dried to obtain hyaluronic acid-modified graphene oxide.

[0069] This embodiment also provides a method for preparing the above-mentioned medical dressing for cesarean section wounds, comprising the following steps:

[0070] (1) adding polyvinyl alcohol to distilled water accounting for one-third of the total amount, heating to 100° C. and stirring thoroughly to dissolve, then cooling to 50° C. and adding hydroxymethyl cellulose, xanthan gum, antimicrobial peptide LL-37, and glycerol, and continuing to stir, and cooling to room temperature to obtain a mixture 1;

[0071] (2) adding distilled water accounting for one third of the total amount to the bitter zucchini extract and the hyaluronic acid-modified graphene oxide and stirring thoroughly to obtain a mixture 2;

[0072] (3) adding recombinant humanized type III collagen and acetylmandelic acid to distilled water accounting for one third of the total amount and stirring thoroughly to obtain mixture 3;

[0073] (4) Adding mixture 2 and mixture 3 to mixture 1 and stirring thoroughly until the mixture is uniform, and sterilizing by irradiation to obtain a medical dressing for cesarean section wounds.

[0074] Comparative Example 1

[0075] This comparative example 1 is basically the same as Example 1, except that the bitter zucchini extract is omitted.

[0076] Comparative Example 2

[0077] Comparative Example 2 is substantially the same as Example 1, except that the hyaluronic acid-modified graphene oxide is omitted.

[0078] Comparative Example 3

[0079] This comparative example 3 is substantially the same as Example 1, except that acetylmandelic acid is omitted.

[0080] Comparative Example 4

[0081] Comparative Example 4 is substantially the same as Example 1, except that acetylmandelic acid is omitted and the amount of recombinant humanized type III collagen is increased to 0.18%.

[0082] Test Example 1

[0083] In order to characterize the performance of the medical dressings of Examples 1-3 and Comparative Examples 1-4 of the present invention, the following tests were performed:

[0084] Healthy estrus female SD rats, SPF grade, weighing 350-400 g, were selected and maintained at a controlled temperature of 23°C and a relative humidity of 55±5%, with normal drinking water and diet, and adapted for 7 days. After confirming the rats' pregnancy, on day 19 of gestation, the rats were randomly divided into Example 1-3 groups and Comparative Example 1-4 groups, with 10 rats in each group. A cesarean section model was established in rats according to the following steps: rats were anesthetized with an intraperitoneal injection of 30 mg / kg of Zotazone anesthetic and then disinfected with iodine solution. A 2 cm longitudinal incision was made along the midline of the lower abdomen of the rats to open the abdominal cavity. A 0.5 cm longitudinal incision was made in the middle of the uterus on both sides facing away from the mesentery. The fetuses and placenta were gently squeezed out. The uterine incision was sutured continuously with 6-0 absorbable sutures. The uterus was returned to the abdominal cavity, and the muscles and skin were sutured continuously layer by layer. The rats were fasted for 24 hours after surgery (with free access to water), caged individually, and the ambient temperature maintained at 26-28°C. Gentamicin (14,000 units / kg) was injected intramuscularly for 3 consecutive days to prevent infection.

[0085] (1) Blood coagulation and wound healing

[0086] After closing the abdominal cavity, sterile gauze was immediately used to cover the abdominal wounds of the cesarean section model rats in the blank control group. The wounds of Example 1-3 and Comparative Example 1-4 groups were covered with the corresponding medical dressings, and gentle pressure was applied. The time was immediately counted and stopped when bleeding stopped. The time from the start of coverage to the cessation of bleeding was finally calculated, and the average value was selected as the final test result, as shown in Table 1. The dressings were changed once a day, and the wound healing was observed at the same time. The average healing time (unit: day) for each group was calculated and the results are shown in Table 1.

[0087] Table 1

[0088]

[0089]

[0090] The experimental results in Table 1 show that the medical dressings of Examples 1-3 of the present invention have excellent hemostatic and wound healing abilities. Compared with Example 1, Comparative Example 1 omitted the bitter zucchini extract, and Comparative Example 2 omitted the hyaluronic acid-modified graphene oxide. Both examples showed a decrease in hemostatic efficacy. This is because the hyaluronic acid-modified graphene oxide in the medical dressing of the present invention can adsorb various active substances in the bitter zucchini extract, thereby improving the stability of the bitter zucchini extract and exerting its biological activity. Combined with the adsorption of coagulation factors by graphene oxide, the two work together to effectively promote red blood cell aggregation, accelerate blood coagulation, and significantly accelerate wound healing.

[0091] (2) Scar hyperplasia index

[0092] After the wounds healed, the scar hyperplasia index of the wounds of the rats in each group was measured. The scar hyperplasia index = the vertical distance from the epidermis of the scar protrusion to the subcutaneous muscle tissue / the vertical distance from the epidermis of the surrounding normal skin to the subcutaneous muscle tissue. The experimental results are shown in Table 2.

[0093] Table 2

[0094] Group Scar hyperplasia index Blank control group 3.25 Example 1 1.58 Example 2 1.65 Example 3 1.62 Comparative Example 3 2.36 Comparative Example 4 2.12

[0095] The experimental results in Table 2 demonstrate that the dressings of Examples 1-3 of the present invention significantly reduced the scar hyperplasia index and outperformed Comparative Examples 3-4. Compared to Example 1, Comparative Example 3 omitted acetylmandelic acid, while Comparative Example 4 omitted acetylmandelic acid and increased the amount of recombinant humanized type III collagen to 0.08%. The scar hyperplasia index in Comparative Examples 3 and 4 significantly increased. This demonstrates that acetylmandelic acid and recombinant humanized type III collagen can work synergistically to inhibit wound fibrosis, reduce scar hyperplasia, and improve wound healing quality.

[0096] The above embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and replacements made by technicians in this field on the basis of the present invention fall within the scope of protection required by the present invention.

Claims

1. A medical dressing for cesarean section wounds, characterized in that: The medical dressing for cesarean section wounds includes the following raw materials, measured in percentage by mass: 0.3-0.5% of bitter zucchini extract, 1-2% of hyaluronic acid-modified graphene oxide, 0.05-0.1% of recombinant type III humanized collagen, 0.05-0.1% of antimicrobial peptide LL-37, 0.03-0.08% of acetylmandelic acid, 5-10% of polyvinyl alcohol, 1-5% of hydroxymethyl cellulose, 0.1-0.5% of xanthan gum, 0.5-1.5% of glycerol, and the balance is distilled water.

2. The medical dressing for cesarean section wound according to claim 1, characterized in that: The preparation steps of the bitter zucchini extract are as follows: a bitter zucchini pulp was dried, crushed, and then 6-10 times the amount of water was added and boiled, filtered to obtain a first residue and a first filtrate; 6-10 times the amount of water was added to the first residue and boiled, filtered to obtain a second residue and a second filtrate; b. The first filtrate and the second filtrate were combined and concentrated to obtain an extract. An ethanol aqueous solution was added to the extract for extraction, and then centrifuged to obtain a supernatant, which was concentrated and dried to obtain a bitter zucchini extract.

3. The medical dressing for cesarean section wound according to claim 2, characterized in that: In step a, the two decoctions are both 2-3 hours in duration.

4. The medical dressing for cesarean section wound according to claim 2, characterized in that: In step b, the amount of the ethanol aqueous solution added is 8-10 times that of the extract; the extraction temperature is 45-60° C., and the extraction time is 2-3 hours.

5. The medical dressing for cesarean section wound according to claim 1, characterized in that: The preparation steps of the hyaluronic acid-modified graphene oxide are as follows: S1. Graphene oxide is dispersed in water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added, the pH is adjusted, and then ethylenediamine hydrochloride and 4-dimethylaminopyridine are added to react. The reaction solution after the reaction is filtered, and the solid is collected, washed, and dried to obtain pretreated graphene oxide; S2. Add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to the aqueous solution of hyaluronic acid, adjust the pH, and then add pretreated graphene oxide to react. After terminating the reaction, the reaction solution is dialyzed and freeze-dried to obtain hyaluronic acid-modified graphene oxide.

6. The medical dressing for cesarean section wound according to claim 5, characterized in that: In step S1, the mass ratio of graphene oxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, ethylenediamine hydrochloride and 4-dimethylaminopyridine is 1:(5-8):(10-15):(8-10):(4.5-5.5); the pH is adjusted to 5-5.5; and the reaction time is 24-28 hours.

7. The medical dressing for cesarean section wound according to claim 5, characterized in that: In step S2, the mass ratio of hyaluronic acid, pretreated graphene oxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide is 1:(2-4):(5-8):(10-15); the pH is adjusted to 5-5.5; and the reaction time is 30-35 hours.

8. The medical dressing for cesarean section wound according to claim 5, characterized in that: The molecular weight of the hyaluronic acid in step S2 is 50-200 kDa.

9. The method for preparing the medical dressing for cesarean section wound according to any one of claims 1 to 8, characterized in that: The following steps are involved: (1) adding polyvinyl alcohol to water accounting for one third of the total amount, heating and stirring, cooling after dissolving, and then adding hydroxymethyl cellulose, xanthan gum, antimicrobial peptide LL-37 and glycerol and stirring thoroughly to obtain a mixture 1; (2) adding distilled water accounting for one third of the total amount to the bitter zucchini extract and the hyaluronic acid-modified graphene oxide and stirring thoroughly to obtain a mixture 2; (3) adding recombinant humanized type III collagen and acetylmandelic acid to distilled water accounting for one third of the total amount and stirring thoroughly to obtain mixture 3; (4) Adding mixture 2 and mixture 3 to mixture 1 and stirring thoroughly, and sterilizing by irradiation to obtain a medical dressing for cesarean section wounds.

10. The method for preparing the medical dressing for cesarean section wound according to claim 9, characterized in that: In step (1), the temperature of the heating and stirring is 90-100°C; after dissolution, the temperature is lowered to 45-50°C.

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