Traditional Chinese medicine composition for treating gout disease and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating gout disease and a preparation method thereof, and discloses a formula composition and a preparation process of a pain-rheumatism hot drink for relieving gout joint symptoms and reducing uric acid level. The hot drink for treating rheumatism is prepared from 15 medicinal materials including cortex phellodendri, rhizoma atractylodis, semen coicis, rhizoma dioscoreae colletii, radix gentianae macrophyllae, radix stephaniae tetrandrae, rhizoma smilacis glabrae, radix angelicae sinensis, cortex erythrinae, frankincense, myrrh, fructus chaenomelis lagenariae, radix cyathulae, herba cichorii and radix glycyrrhizae according to a certain dosage ratio. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is compatible with medicines for promoting blood circulation to arrest pain (such as frankincense, myrrh and angelica sinensis) and dredging collaterals (such as radix cyathulae, cortex erythrinae and pawpaw), is suitable for acute attack of the damp-heat accumulation type gouty arthritis and has the treatment purpose of relieving joint redness, swelling and heat pain of gout patients as soon as possible, and is faster in effect and good in effect compared with an existing prescription.

Description

Technical field: The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating gout and a preparation method thereof. Background technology: With the development of society and the continuous improvement of people's living standards, the prevalence of gouty arthritis has been increasing year by year due to changes in modern people's diet. The onset of gouty arthritis has caused great distress to many patients. Due to the unbearable pain and limited mobility during an attack, their daily life and work are affected.

[0001] Chinese invention patent application CN117338886B discloses a traditional Chinese medicine composition for treating gout and a preparation method thereof. The composition comprises 120-160 parts of Smilax glabra, 35-50 parts of Astragalus membranaceus, 35-50 parts of Plantago seed, 25-45 parts of Fraxinus fraxinus, 15-35 parts of Atractylodes macrocephala, 25-40 parts of Atractylodes macrocephala, 25-45 parts of Siegesbeckia officinalis, 25-45 parts of Lycopodiella ciliata, 20-40 parts of Clematidis, 7-30 parts of Polygonum multiflorum, and 5-20 parts of Epimedium. The preparation method comprises: 1. taking the medicinal materials, decocting them with water, filtering, and combining the filtrate; 2. concentrating the filtrate, adding auxiliary materials, and drying to obtain a powder; and 3. adding the auxiliary materials to the powder and mixing them to obtain granules. The preparation method is relatively complicated and inconvenient to operate.

[0002] However, the drug treatment disclosed in the above invention takes effect slowly, and it takes an average of 4 weeks for the patient's blood uric acid level to decrease to normal levels.

[0003] At the same time, in order to relieve the joint pain symptoms of gout and treat the joint pain caused by gout, etoricoxib is often used for treatment. However, etoricoxib has no effect on lowering blood uric acid, and the pain symptoms will recur after discontinuation of the drug, which only treats the symptoms but not the root cause. Summary of the invention: The purpose of the present invention is to provide a traditional Chinese medicine composition for treating gout and a preparation method thereof to solve the existing problems.

[0004] The present invention is implemented by the following technical scheme: a traditional Chinese medicine composition for treating gout, which is composed of the following raw materials in parts by weight: 10-20 parts of phellodendron amurense, 6-12 parts of atractylodes lancea, 10-30 parts of coix seed, 10-15 parts of radix polygoni multiflori, 10-15 parts of gentiana macrophylla, 6-10 parts of tetrandra, 15-60 parts of smilax glabra, 6-15 parts of angelica sinensis, 10-20 parts of pittosporum tobira bark, 5-10 parts of frankincense, 5-10 parts of myrrh, 10-15 parts of papaya, 10-15 parts of cyathula, 5-10 parts of liquorice, and 9-18 parts of chicory.

[0005] A method for preparing the above-mentioned Chinese medicine composition comprises the following steps: S1: Weigh the medicinal materials, add water to a container and soak for 4-8 hours, boil over high heat, and filter to obtain the first decoction; S2: adding water to the medicinal materials filtered in step S1 and decocting again, filtering after decocting to obtain a second decoction, and combining the first decoction and the second decoction to obtain the Chinese medicine composition.

[0006] Furthermore, in step S1, the weight of water added is 5 times the total weight of the medicinal materials, and the mixture is decocted for 25-30 minutes; and in step S2, the weight of water added is 4 times the total weight of the medicinal materials, and the mixture is decocted for 25-30 minutes.

[0007] Furthermore, the container is one of an enamel pot, a casserole, a stainless steel pot, and a glass frying pan.

[0008] Advantages of the present invention: The Gout and Rheumatism Drink of the present invention is an internal decoction with heat-clearing and dampness-removing herbs (such as Phellodendron amurense, Coix seed, Radix Dichroae, and Radix Stephaniae Tetrandrae) as its core, combined with herbs that promote blood circulation and relieve pain (such as frankincense, myrrh, and Radix Angelicae Sinensis) and meridian-opening herbs (such as Cyathulae Rhizoma, Pittosporum tobira bark, and Chaenomeles sinensis). It is suitable for acute attacks of gouty arthritis of the damp-heat accumulation type, with the goal of quickly relieving the redness, swelling, heat, and pain in the joints of gout patients. The present invention uses Simiao Powder as the main ingredient to clear damp-heat; Radix Dichroae, Radix Gentianae, Radix Stephaniae Tetrandrae, and Radix Smilacis Glabrae as the auxiliary ingredients to eliminate damp-heat and promote joint circulation; Radix Angelicae Sinensis, Pittosporum tobira bark, frankincense, myrrh, Chaenomeles sinensis, and Radix Chicory as the auxiliary ingredients to promote blood circulation and relieve pain, and dredge the meridians; and Radix Licorice as the guiding ingredient to harmonize the various herbs. The combination of various medicines can clear away dampness and heat and dredge the meridians at the same time, treating both the symptoms and the root causes. The whole prescription has the effects of clearing away heat and dampness, relaxing muscles and tendons and dredging the meridians. Compared with the existing technology, the traditional Chinese medicine composition disclosed in the present invention has the advantage of fast onset of effect, and blood uric acid can be reduced to normal levels within one week. Specific implementation method: In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0009] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0010] Unless otherwise specified, the materials and reagents used in the examples of the present invention can be obtained from commercial sources. The basic information of the main raw materials is as follows:

Phellodendron chinense

[0011] Functions and indications: Clears away heat and dampness, purges fire and detoxifies.

[0012]

Atractylodes lancea

[0013] Functions and indications: Drying dampness and strengthening the spleen.

[0014]

Job's tears

[0015] Therapeutic functions and indications: Promote diuresis to eliminate dampness, invigorate the spleen, relieve arthralgia, and detoxify.

[0016]

Rhizoma Dioscoreae Hypoglauca

[0017] Therapeutic functions and indications: Promote diuresis to remove turbid substances, dispel wind and relieve arthralgia.

[0018]

Gentiana Macrophylla

[0019] Therapeutic functions and indications: Dispel wind-dampness, clear damp-heat, relax tendons and collaterals, and relieve arthralgia pain.

[0020]

Stephania Tetrandra

[0021] Therapeutic functions and indications: Dispel wind-dampness and relieve pain.

[0022]

Smilax Glabra

[0023] Therapeutic functions and indications: Detoxify, eliminate dampness, and promote joint movement.

[0024]

Angelica Sinensis

[0025] Therapeutic functions and indications: Promote blood circulation to relieve pain.

[0026]

Erythrina Arborescens

[0027] Therapeutic functions and indications: Dispel wind-dampness, dredge collaterals and relieve pain.

[0028]

Boswellia Carterii

[0029] Therapeutic functions and indications: Promote blood circulation, relieve pain, and reduce swelling.

[0030]

Commiphora Myrrha

[0031] Therapeutic functions and indications: Promote blood circulation to remove stasis, relieve pain, and reduce swelling.

[0032]

Chaenomeles Sinensis

[0033] Therapeutic functions and indications: Relax tendons and activate collaterals, promote digestion and regulate the middle energizer.

[0034]

Cyathula Officinalis

[0035] Functions and indications: Promote blood circulation, remove blood stasis, dispel wind and dampness.

[0036] Licorice Nature and flavor: sweet, neutral. Enters the heart, lung, spleen and stomach meridians.

[0037] Functions and indications: Clears away heat and detoxifies, harmonizes various medicines.

[0038]

endive

[0039] Functions and indications: Clears the liver and promotes bile secretion, clears heat and removes dampness.

[0040] The prescription, based on tonic herbs (such as Astragalus, Atractylodes macrocephala, Polygonum multiflorum, and Epimedium), also incorporates herbs that dispel dampness and dredge the meridians (such as Smilax glabra, Plantago seed, Atractylodes lancea, and Siegesbeckia sibiricum). The entire prescription emphasizes tonifying the spleen and kidneys, replenishing qi and blood, and achieving the combined effects of invigorating the spleen and kidneys, dispelling dampness and dredge the meridians, while also strengthening the body's resistance and dispelling pathogenic factors. It is suitable for chronic gouty arthritis characterized by both spleen and kidney deficiency. The extremely high dosage of Smilax glabra in the prescription highlights its detoxifying, dampness-removing, and joint-opening properties, making it suitable for more stubborn joint symptoms.

[0041] Example 1: Weigh 10g of Phellodendron amurense, 6g of Atractylodes lancea, 10g of Coix seed, 10g of Radix Dipterocarpa, 10g of Gentiana macrophylla, 6g of Stephania tetrandra, 15g of Smilax glabra, 6g of Angelica sinensis, 10g of Pittosporum tobira bark, 5g of frankincense, 5g of myrrh, 10g of papaya, 10g of Cyathula capitata, 5g of licorice, and 9g of chicory respectively, put them in an enamel pot, add 635g of water, simmer for 30 minutes, filter to obtain a first decoction, put the remaining medicinal materials back into the enamel pot, add 508g of water, simmer for 30 minutes, filter to obtain a second decoction, and combine the first decoction and the second decoction to obtain the traditional Chinese medicine composition.

[0042] Example 2: 15 g of Phellodendron chinense, 10 g of Atractylodes lancea, 20 g of Coix seed, 13 g of Radix Dipterocarpa, 12 g of Gentiana macrophylla, 8 g of Stephania tetrandra, 40 g of Smilax glabra, 8 g of Angelica sinensis, 15 g of Pittosporum tobira bark, 8 g of frankincense, 8 g of myrrh, 13 g of papaya, 13 g of Cyathula capitata, 8 g of Licorice, and 15 g of chicory were weighed respectively, placed in an enamel pot, 1030 g of water was added, and the mixture was decocted on a fire for 30 minutes. After filtering, a first decoction was obtained, and the remaining medicinal materials were returned to the enamel pot, 824 g of water was added, and the mixture was decocted on a fire for 30 minutes. After filtering, a second decoction was obtained, and the first decoction and the second decoction were combined to obtain the traditional Chinese medicine composition.

[0043] Example 3: 20 g of Phellodendron amurense, 12 g of Atractylodes lancea, 30 g of Coix seed, 15 g of Radix Dipterocarpa, 15 g of Gentiana macrophylla, 10 g of Stephania tetrandra, 60 g of Smilax glabra, 15 g of Angelica sinensis, 20 g of Pittosporum tobira bark, 10 g of frankincense, 10 g of myrrh, 15 g of papaya, 15 g of Cyathula capitata, 10 g of Licorice, and 18 g of chicory were weighed respectively, placed in an enamel pot, 1375 g of water was added, and the mixture was decocted on a fire for 30 minutes. After filtering, a first decoction was obtained. The remaining medicinal materials were put back into the enamel pot, 1100 g of water was added, and the mixture was decocted on a fire for 30 minutes. After filtering, a second decoction was obtained. The first decoction and the second decoction were combined to obtain the traditional Chinese medicine composition.

[0044] In the above-mentioned Examples 1-3, the container is one of an enamel pot, a casserole, a stainless steel pot, or a glass frying pan. This is because iron pots and copper pots are chemically unstable and easily oxidized, affecting the activity of the active ingredients in various Chinese medicines. The Compendium of Materia Medica clearly states: "Iron is pungent, flat, and poisonous. ... All herbal medicines should avoid iron utensils, and kidney-tonifying medicines are especially taboo." Modern research shows that botanicals are mostly acidic or alkaline, with very few neutral ones. They often contain tannins, organic acids, phenolic hydroxyl compounds, and other components, all of which react with iron ions. Some plants contain flavonoids, which can also form insoluble substances with metallic iron, all of which will affect the efficacy of the drugs.

[0045] In order to verify the efficacy of the drug of the present invention, the inventors conducted clinical trials. The research methods and test results adopted are as follows: 1. Patient composition: 66 patients with acute gouty arthritis (damp-heat accumulation type) who received diagnosis and treatment in the outpatient department and inpatient ward of the Department of Rheumatology, Mongolian Medicine and Traditional Chinese Medicine Hospital of Hohhot from August 2023 to December 2024 were collected and randomly divided into two groups, namely, the control group and the embodiment group of the present invention, each of which included 33 patients. Among them, 33 people in the embodiment group were randomly divided into 3 groups, and they were treated with the Chinese medicine compositions of Example 1, Example 2 and Example 3 of the present invention, respectively.

[0046] Specific grouping and treatment methods (1) Control group: In addition to basic treatment, oral administration of etoricoxib tablets (National Medicine Standard No. H20193273; Product Name: Etoricoxib Tablets), 60 mg / time, once / day, 7 days as a course of treatment, take 1 course of treatment.

[0047] The basic treatment includes controlling the patient to abstain from smoking and drinking, limit high-purine diet, reduce strenuous exercise, prevent cold, drink plenty of water, control weight, and have a regular diet and rest schedule.

[0048] (2) Example group: On the basis of basic treatment, the Chinese medicine composition of the present invention was given in combination with etoricoxib tablets for treatment.

[0049] The Chinese medicine composition of the invention is taken twice a day, morning and evening, after meals. Seven days constitute one course of treatment, and one course of treatment is taken.

[0050] Etoricoxib tablets (National Medicine Standard No. H20193273; product name: Etoricoxib tablets), 60 mg / time, once / day, 7 days as a course of treatment, take 1 course of treatment.

[0051] The two groups of patients underwent blood tests before treatment and one week after treatment, respectively. The inflammatory indicators C-reactive protein (CRP) and uric acid (UA) levels of each group of patients were recorded and the average values were calculated. The results are shown in Table 1.

[0052] Table 1 Comparison of CRP and UA levels before and after treatment in the two groups ( )

[0053] The above experiments showed that both the control group using etoricoxib tablets alone and the example group using the Chinese medicine composition of the present invention in combination with etoricoxib tablets could reduce the level of C-reactive protein (CRP), an inflammatory indicator. However, the CRP levels of patients in Example 1-3 groups were lower than those in the control group after one week of treatment (P<0.05). Inter-group comparison showed that the uric acid levels of patients in Example 1-3 groups were lower than those in the control group after one week of treatment (P<0.05). Among them, the patients in Example 3 group had the best effect in reducing the blood uric acid level after one week of treatment. According to the "Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout in China (2019)", under a normal purine diet, blood uric acid levels should be less than 420 μmol / L in adults, regardless of gender, when fasting blood is drawn on two different days. Therefore, the blood uric acid level can be reduced to the normal range after one week of treatment with the Chinese medicine composition disclosed in the present invention, and the effect is faster than that of the prior art. In summary, the Chinese medicine composition of the present invention has the effect of controlling inflammation and lowering blood uric acid.

Claims

1. A Chinese medicine composition for treating gout, characterized in that: The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 10-20 parts of phellodendron amurense, 6-12 parts of atractylodes lancea, 10-30 parts of coix seed, 10-15 parts of radix polygoni multiflori, 10-15 parts of gentiana macrophylla, 6-10 parts of stephania tetrandra, 15-60 parts of smilax glabra, 6-15 parts of angelica sinensis, 10-20 parts of pittosporum tobira bark, 5-10 parts of frankincense, 5-10 parts of myrrh, 10-15 parts of papaya, 10-15 parts of cyathula, 5-10 parts of licorice, and 9-18 parts of chicory.

2. A method for preparing the Chinese medicine composition according to claim 1, characterized in that: The following steps are involved: S1: Weigh the medicinal materials, add water to a container and soak for 4-8 hours, boil over high heat, and filter to obtain the first decoction; S2: adding water to the medicinal materials filtered in step S1 and decocting again, filtering after decocting to obtain a second decoction, and combining the first decoction and the second decoction to obtain the Chinese medicine composition.

3. The method for preparing the Chinese medicine composition according to claim 2, wherein In step S1, the weight of water added is 5 times the total weight of the medicinal materials, and the mixture is decocted for 25-30 minutes; in step S2, the weight of water added is 4 times the total weight of the medicinal materials, and the mixture is decocted for 25-30 minutes.

4. The method for preparing the Chinese medicine composition according to claim 2, wherein The container is one of an enamel pot, a casserole, a stainless steel pot and a glass frying pan.

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