Particle implantation apparatus and method of positioning implants

Abstract

The present application relates to a kind of particle implantation equipment and positioning implantation method, the equipment includes frame body, with the implantation tube fixedly connected to frame body;Pusher is installed on the frame body;Particle bin, between the implantation tube and the pusher, when one of the particles is located in the implantation tube and the pusher line, the particle is placed in the particle bin;The circumferential side of the particle is formed with helical line type protrusion along its length direction, and the pusher includes threaded screw-in push rod, the threaded screw-in push rod is driven to rotate and slide and drive the particle to rotate and advance along the length direction of the implantation tube.By the above setting, the position of particle implantation is stable, and displacement is not easily generated, and the adaptability of implantation equipment and particle is high.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of hyperthermia, in particular to a particle implanting device and a positioning implanting method. BACKGROUND

[0002] For prostate tumors, the main treatment methods currently include surgical treatment, radiotherapy and drug treatment. The surgical treatment has high risk, and its applicability is limited for some patients who are older and have more underlying diseases; the radiotherapy is difficult to control stably due to the radioactivity of the adopted scheme, and is easy to cause radiation damage to the surrounding tissues; the drug treatment will bring many side effects to the patient's body, and even normal cells will be killed during chemotherapy.

[0003] Based on the above reasons, the current alternative is a way of using heat therapy particles, which uses an external energy field to excite particles implanted in the tumor position, so that the particles generate heat and achieve the effect of destroying tumor cells, which overcomes the above defects.

[0004] However, since the particles need to be implanted into the tumor position in the body, the requirements for the operator are relatively high, not only the implantation needs to be accurate, but also the position needs to be maintained stable during the subsequent treatment period, otherwise the heat therapy range, intensity and other parameters designed in the heat therapy scheme cannot achieve the desired effect, and even the surrounding benign tissue cells will be damaged. For the implantation of heat therapy particles, the current more common method is still to use the channel formed by the puncture needle to implant the particles into the body by using the implant gun, but the current conventional implant gun on the market is designed for the implantation of radioactive particles. Since radiotherapy and heat therapy are two completely different treatment schemes, the structure design also considers the particularity of radiotherapy, resulting in many incompatibilities between the heat therapy particles, which cannot be directly used. SUMMARY

[0005] In order to solve the above defects, the present application provides a particle implanting device and a positioning implanting method.

[0006] The technical scheme adopted by the present application is that the particle implanting device for magnetic heat therapy particles comprises a frame body, and the frame body is further provided with:

[0007] An implanting tube is fixedly connected with the frame body and guides the particles to pass through;

[0008] A pushing device is installed on the frame body and applies an acting force to the particles to make them pass through the implanting tube;

[0009] A particle bin is located between the implanting tube and the pushing device, and when the particles are placed in the particle bin, one of the particles is located on the connecting line of the implanting tube and the pushing device;

[0010] The helical protrusions are formed on the circumferential side of the particle along the length direction of the particle, the pushing device comprises a screw thread rotating push rod, the screw thread rotating push rod rotates and slides after being driven, and drives the particle to rotate and advance along the length direction of the implantation tube. The rotating direction of the particle is consistent with the helical direction of the helical protrusions.

[0011] Preferably, the screw thread rotating push rod is provided with a buffer layer at the end in contact with the particle, the buffer layer is made of biocompatible flexible material, and at least one micro protrusion is arranged on the side of the buffer layer in contact with the particle. When the buffer layer is in contact with the particle, the micro protrusion can abut against the side of the helical protrusion on the particle.

[0012] Preferably, the pushing device comprises a micro motor, a transmission turbine and an electric control button, the electric control button is arranged on the frame body and starts and stops the micro motor, the transmission turbine is power connected with the micro motor and drives the screw thread rotating push rod to rotate.

[0013] Preferably, the frame body is further fixed with a guide rod, an open-ended cavity is formed along the length direction of the screw thread rotating push rod at the axis of the screw thread rotating push rod, and the guide rod is inserted into the cavity and rotationally matched with the screw thread rotating push rod.

[0014] Preferably, the particle bin comprises a fixed seat and a bin body, the fixed seat is fixed on the frame body, the bin body is detachably connected with the fixed seat, and the particle is stored in the bin body.

[0015] Preferably, the implantation tube comprises an integrally connected tube body and a head, the cross section of the head along the axis direction gradually increases, and the opening end is adaptively connected with the fixed seat.

[0016] Preferably, the inner walls of the tube body and the head are coated with a polytetrafluoroethylene coating.

[0017] Preferably, the particle comprises a front end and a tail end along the length direction of the particle, the helical protrusions are located between the front end and the tail end, and a plurality of barbs made of polycaprolactone are fixed at the tail end of the particle. The free ends of the plurality of barbs are pre-tightened and fixed on an embolization sheet, and the embolization sheet is made of a water-soluble material with good biocompatibility.

[0018] The end of the screw thread rotating push rod is concave and forms an avoiding cavity, and when the screw thread rotating push rod abuts against the tail end of the particle, the barbs of the particle are accommodated in the avoiding cavity.

[0019] The application further provides a positioning implantation method using the particle implantation device according to any one of the preceding embodiments, the method comprising: positioning an implantation position of the magnetic-thermal particles, determining an implantation path, and implanting the particles into the predetermined implantation position according to the implantation path.

[0020] Preferably, the method further comprises fixing the position of the particles after implanting into the predetermined implantation position, and the fixing manner comprises at least one of thermal coagulation self-fixing of the magnetic-thermal particles, fixing formed between the spiral-line protrusions on the outer surface of the particles and cells, or fixing formed after releasing the barbs at the tail end of the particles.

[0021] Compared with the prior art, the application has the following beneficial effects:

[0022] 1. The spiral-line protrusions are formed on the surface of the magnetic-thermal particles, which facilitates the particles to form more stable wrapping and fixing with the surrounding cells after entering the tumor cells, and reduces postoperative particle displacement.

[0023] 2. Since the particles have certain resistance when being pushed in the implantation tube, and the spiral-line protrusions increase the resistance, a threaded screw-in push rod is designed, which is pushed in a spiral manner to drive the particles to rotate, and the spiral characteristics of the spiral-line protrusions are utilized to overcome the resistance during the screwing-in process, and the screwing-in process is more stable.

[0024] 3. The buffer layer can greatly absorb the stress during impact, and avoid damage to the tail end of the particles by the threaded screw-in push rod, especially when the tail end is provided with barbs.

[0025] 4. The barbs at the tail end of the particles can be fixed with the surrounding cells to avoid displacement after entering the tumor cells in the body temperature environment, and the barbs made of polycaprolactone can be softened after heating for thermotherapy, which does not affect the radiation of the heat field and can be smoothly taken out.

[0026] 5. In order to adapt to the barb structure, the end of the threaded screw-in push rod is recessed to form a avoiding cavity, and when the threaded screw-in push rod abuts against the tail end of the particles, the barbs of the particles are accommodated in the avoiding cavity, and the pushing and rotating are not affected. BRIEF DESCRIPTION OF DRAWINGS

[0027] The application will be described in detail below with reference to the embodiments and the accompanying drawings, in which:

[0028] Figure 1 is an isometric view of one embodiment of the application;

[0029] Figure 2 is Figure 1Figure 2 is a schematic view of the fixed seat in the middle, showing the internal structure of the fixed seat and the relationship between adjacent structures after one side surface structure is removed;

[0030] Figure 3 Figure 1 is a schematic view of the structure of a particle and a threaded screw-in push rod in one embodiment of the present application. Figure 2 Figure 2 is a schematic view of the fixed seat in the middle, showing the internal structure of the fixed seat and the relationship between adjacent structures after one side surface structure is removed;

[0031] Figure 4 Figure 1 is a schematic view of the structure of a particle and a threaded screw-in push rod in one embodiment of the present application.

[0032] Figure 1 is a schematic view of the structure of a particle and a threaded screw-in push rod in one embodiment of the present application. Figure 2 Figure 1 is a schematic view of the structure of a particle and a threaded screw-in push rod in one embodiment of the present application. Figure 3 Figure 1 is a schematic view of the structure of a particle and a threaded screw-in push rod in one embodiment of the present application.

[0033] 10, frame; 11, particle bin; 12, fixed seat; 13, bin body; 14, guide rod; 20, implant tube; 21, tube body; 22, head; 30, micro motor; 31, transmission turbine; 32, electric control button; 33, threaded screw-in push rod; 34, avoiding cavity; 40, particle; 41, helical protrusion; 42, barb; 50, insertion spring; 51, compression spring. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical scheme and advantages of the present application more clear, the following will further describe the embodiments of the present application in combination with the drawings. The examples of the embodiments are shown in the drawings, wherein the same or similar reference signs represent the same or similar parts or parts having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present application, but cannot be explained as a limitation of the present application.

[0035] The present application discloses a particle implantation device, which is applied to the field of magnetic hyperthermia and particularly to the implantation of magnetic heat particles. In order to improve the position stability of the particles after implantation into tumor cells, the structure of the particles is designed in the present application, so that helical protrusions are formed on the circumferential side in the length direction. Of course, in different processes, helical grooves can also be formed, and the pitch is set to 0.5 mm. In this way, after the particles are implanted into the body, the protrusions or grooves are more likely to form wrapping and adsorption with the cells, thereby improving the stability of the particles in the body.

[0036] At present, there are many implantation guns on the market for radiotherapy particles, but their design is not suitable for the particles in the present application. Because the surface of the radioactive particles, such as I-125, is smooth (Ra<0.5 μm), the barbs or helical grooves of the hyperthermia particles will mechanically fit with the metal channel of the implantation gun, the pushing resistance will increase by 3-5 times, the particles will rotate and deviate in the gun barrel, the positioning error will be >0.5 mm, and if the diameter of the gun barrel is further reduced to reduce the error, the pushing resistance will be further increased, and even the end of the particle will be damaged.

[0037] In addition, the push rod of the radiation implant gun generates high heat when repeatedly pushing the particles, which does not affect the subsequent radiation treatment for the radioactive particles, but the surface of the magnetic hyperthermia particle has a coating, and in an embodiment of the present application, the tail end of the particle is also provided with a barb which is constrained by the embolism sheet before entering the body. If the temperature of the gun barrel rises to a certain degree, the barb will soften, and the push rod will also have continuous contact and friction with the next particle in the particle bin ready to enter the gun barrel, which will also damage the coating on the surface of the particle. Various problems such as the above are the reasons why the existing radioactive particle implant gun is not suitable for magnetic hyperthermia particle implantation.

[0038] In an embodiment, as shown in Figures 1-2 The particle implantation device comprises a frame body 10, and the frame body 10 is further provided with:

[0039] An implantation tube 20 which is fixedly connected with the frame body 10 and guides the particles 40 to pass through;

[0040] A pushing device which is installed on the frame body 10 and applies an acting force to the particles 40 to make them pass through the implantation tube 20;

[0041] A particle bin 11 which is located between the implantation tube 20 and the pushing device, and when the particles 40 are placed in the particle bin 11, one of the particles 40 is located on the line connecting the implantation tube 20 and the pushing device;

[0042] As shown in Figure 4 The particles 40 are formed with helical line protrusions 41 along the circumferential side of the length direction, and the pushing device comprises a threaded screw-in push rod 33 which rotates and slides after being driven to rotate and drive the particles 40 to rotate and advance along the length direction of the implantation tube 20.

[0043] As shown in Figures 1-2 The particle bin 11 comprises a fixed seat 12 and a bin body 13, the fixed seat 12 is fixed on the frame body 10, the bin body 13 is detachably connected with the fixed seat 12, and the particles 40 are stored in the bin body 13. The implantation tube 20 is fixed on the frame body 10 and comprises an integral tube body 21 and a head part 22, the cross section of the head part 22 gradually increases along the axial direction, and the opening part is adapted and connected with the fixed seat 12, that is, the particles 40 fall into the fixed seat 12 from the bin body 13 in sequence, and are pushed into the implantation tube 20 from the same direction by the threaded screw-in push rod 33.

[0044] The fixed seat 12 can be integrally formed with the frame 10, and is located between the implant tube 20 and the pushing device. The fixed seat 12 includes at least three openings, one pair of which is used for the screw-in and out of the extension of the push rod 33, so as to complete the pushing of the particle 40, and the other opening is upward, used for the particle 40 to fall into the fixed seat 12 from the cartridge body 13. The cartridge body 13 can store a plurality of particles 40, and the detachable design between the cartridge body 13 and the fixed seat 12 can be a conventional buckle or plug-in design, or other common detachable ways; similarly, the design of the cartridge body 13 can also refer to the particle 40 storage structure of the magazine or the radioactive implant gun, which can be a simple one-end opening shell for placing a plurality of particles 40, or a spring can be arranged in the shell to apply an elastic force to the particle 40 to push it out.

[0045] The enlarged design of the head 22 of the implant tube 20 makes it easier for the particle 40 to enter the tube body 21, avoiding the mechanical resistance of the particle 40 when the position deviates from the tube opening of the implant tube 20. The tube body 21 of the implant tube 20 extends into the body, and the particle 40 and the screw-in push rod 33 pass through the head 22 and enter the tube body 21.

[0046] In an embodiment, in order to reduce the friction and heat during sliding, the inner walls of the tube body 21 and the head 22 of the implant tube 20 are coated with a polytetrafluoroethylene coating.

[0047] In an embodiment, in order to avoid too much impact force of the screw-in push rod 33 on the particle 40, a buffer layer is arranged at the end of the screw-in push rod 33 in contact with the particle 40, and the buffer layer is made of biocompatible flexible material, specifically, a 100 μm thick silica gel pad (not shown in the figure).

[0048] Further, at least one micro-protrusion is arranged on the side of the buffer layer in contact with the particle 40, and when the buffer layer is in contact with the particle 40, the micro-protrusion can abut against the side of the helical protrusion 41 on the particle 40. As preferred, the micro-protrusion can be arranged as one pair or more, so that when the screw-in push rod 33 is in contact with the particle 40, the screw-in push rod 33 is driven to rotate, the micro-protrusion abuts against the side of the helical protrusion 41 and drives the particle 40 to rotate synchronously. Of course, the rotating direction of the screw-in push rod 33 and the particle 40 is consistent with the helical direction of the helical protrusion 41. In addition, even if the micro-protrusion fails to abut against the side of the helical protrusion 41 and drive the particle 40 to rotate synchronously, it can also achieve the effect of driving the particle 40 to rotate by relying on the friction force.

[0049] In one embodiment, the pushing device comprises a micro motor 30, a transmission turbine 31 and an electric control button 32, the electric control button 32 is arranged on the frame body 10 and starts and stops the micro motor 30, the transmission turbine 31 is power connected with the micro motor 30 and drives the threaded screw rod 33 to rotate. Wherein the electric control button 32 can also be arranged as two, respectively controlling the forward rotation and reverse rotation of the micro motor 30, so as to correspond to the rotation or exit of the threaded screw rod 33.

[0050] Further, the frame body 10 is also fixed with a guide rod 14, the axis of the threaded screw rod 33 is formed with an open cavity in the length direction, the guide rod 14 is inserted into the cavity and is matched with the threaded screw rod 33.

[0051] The guide rod 14 plays a role of limiting constraint and guidance for the threaded screw rod 33, so that the threaded screw rod 33 can keep the matching relationship with the turbine, after the turbine is driven by the micro motor 30, the rotation and sliding of the threaded screw rod 33 are realized, and the length of the guide rod 14 needs to be greater than the stroke of the threaded screw rod 33, so as to further improve the stability and precision of the linear reciprocating motion of the threaded screw rod 33.

[0052] In the foregoing embodiment, it is introduced that the bin body 13 and the fixed seat 12 are detachably arranged, in this embodiment, the bin body 13 is installed above or on the side of the fixed seat 12, if it is above, it can rely on the weight of the particles 40 to fall into the fixed seat 12 in turn, if it is on the side, it needs to rely on the action of the spring to push the particles 40 into the fixed seat 12 in turn. However, no matter the installation position, when the first particle 40 is in the pushing process, the next particle 40 in the bin body 13 ready to enter the fixed seat 12 will inevitably abut against the threaded screw rod 33, and the threads on the threaded screw rod 33 will generate serious friction with the next particle 40 in the process of advancing or retreating of the threaded screw rod 33.

[0053] In order to solve this problem, the embodiment further installs a plug-in spring 50 on the frame body 10, as shown in Figures 1-3 The plug-in spring 50 is slidingly constrained on the frame body 10, and the compression spring 51 is arranged between one end of the plug-in spring 50 and the frame body 10, and the other end of the plug-in spring 50 can be inserted into the gap between the bin body 13 and the fixed seat 12 under the action of the compression spring 51.

[0054] Specifically, the plug-in spring 50 is in an L shape as a whole, the horizontal section of which is arranged in parallel with the threaded push rod 33, and the vertical section is used for mounting the compression spring 51. The end of the horizontal section is provided with a bevel or arc surface, which, when inserted into the gap between the cartridge body 13 and the fixed seat 12, can abut against the particle 40 in the cartridge body 13 and prevent the particle 40 from moving further into the fixed seat 12, and in the whole process of the threaded push rod 33 pushing the first particle 40, the next particle 40 is also isolated from the threaded push rod 33, avoiding the friction between the next particle 40 and the threaded push rod 33.

[0055] In one embodiment, the plug-in spring 50 is in a T shape as a whole, the horizontal section of which is arranged in parallel with the threaded push rod 33, and the upper half of the vertical section is used for mounting the compression spring 51, and the lower half abuts against the end of the threaded push rod 33.

[0056] As preferred, the cross section of the particle 40 is circular, and the horizontal section of the plug-in spring 50 is inserted into the gap between the cartridge body 13 and the fixed seat 12 at a distance of one third or one fourth of the diameter of the cross section of the particle 40, that is, it does not need to be inserted too deep to achieve the plug-in limiting of the particle.

[0057] In the present embodiment, the vertical section of the plug-in spring 50 is located between the end of the threaded push rod 33 and the end of the frame body 10, and when the threaded push rod 33 is reset and the end thereof abutting against the particle 40 exits the fixing of the particle cartridge 11, the other end of the threaded push rod 33 abuts against the vertical section of the plug-in spring 50 and drives the plug-in spring 50 to slide along the frame body 10 until the plug-in spring 50 exits the fixed seat 12. At this time, the particle 40 in the cartridge body 13 loses the limiting constraint of the plug-in spring 50 and can smoothly enter the fixed seat 12. After the threaded push rod 33 is restarted, the threaded push rod 33 pushes the particle 40 in the fixed seat 12 into the implantation tube 20, and the threaded push rod 33 no longer abuts against the vertical section of the plug-in spring 50, so the plug-in spring 50 as a whole slides again under the action of the compression spring 51 until it is inserted into the gap between the cartridge body 13 and the fixed seat 12.

[0058] In one embodiment, in order to improve the stability of the implanted magnetic hyperthermia particles 40 and reduce displacement, the particle 40 is also improved and designed, specifically, as shown in Figure 4 the particle 40 includes a front end and a tail end along the length direction thereof, the helical line type protrusion 41 is located between the front end and the tail end, and a plurality of barbs 42 made of polycaprolactone are fixed at the tail end of the particle 40, the free ends of the plurality of barbs 42 are pre-tightened and fixed on an embolization sheet (not shown in the figure), and the embolization sheet is made of a water-soluble material with good biocompatibility.

[0059] The end of the threaded screwing push rod 33 is concave to form a avoiding cavity 34, when the threaded screwing push rod 33 abuts against the tail end of the particle 40, the barbs 42 of the particle 40 are all received in the avoiding cavity 34.

[0060] In this embodiment, the height of the barbs 42 is 0.1-0.3mm, and the number is more than 2, which can be 3 or more. The shape of the barbs 42 is preferably strip-shaped or columnar, and the multiple barbs 42 are arranged radially at the tail end of the particle 40, that is, the end with close distance between adjacent barbs 42 is fixed on the tail end of the particle 40, and the end with far distance is the free end and inclines outward.

[0061] Since the barbs 42 are made of polycaprolactone, they have high hardness in a body temperature environment, so the multiple barbs 42 will be opened and abut against the surrounding cells to further stabilize the installation position of the particle 40. When heat therapy is performed, the temperature reaches 40-50℃, the barbs 42 will soften, which does not affect the curative effect of the heat field, and at this time, the human body generally does not move in the treatment process, and the particle 40 can be taken out after heating, and the barbs 42 will not be affected.

[0062] In this embodiment, when the particle 40 is implanted, a plug sheet is used to constrain the barbs 42, which aims to avoid the barbs 42 from opening and rubbing against the pipe body 21 of the implantation tube 20 during the implantation process, and after entering the body, the plug sheet made of water-soluble material with good biocompatibility will dissolve to release the barbs 42. Specifically, the plug sheet is made of hydroxypropyl methyl cellulose, and the dissolution time is about 30s. The plug constraint mode of the barbs 42 can be that the multiple barbs 42 are wrapped, or a hollow is formed on the plug sheet, and the multiple barbs are constrained in the hollow.

[0063] The application also discloses a positioning implantation method of magnetic heat therapy particles, which adopts the particle implantation device as described above, and the method comprises the following steps: positioning the implantation position of the magnetic heat therapy particles, determining the implantation path, implanting the particles into the predetermined implantation position according to the implantation path, and fixing the position of the particles. The fixing mode comprises at least one of the following: heat coagulation self-fixing of the magnetic heat therapy particles, fixing formed between the spiral line type protrusions formed on the outer surface of the particles and cells, or fixing formed after the barbs at the tail end of the particles are released.

[0064] In one embodiment, the fixing mode of the particles simultaneously adopts the above three modes.

[0065] In the description of the specification, if the terms "embodiment one", "this embodiment", "in one embodiment", etc. are described, it means that the specific features, structures, materials or characteristics described in conjunction with this embodiment or example are included in the invention or at least one embodiment or example of the invention. In this specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example; moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in an appropriate manner.

[0066] In the description of the specification, the terms "connection", "installation", "fixation", "setting", "have" and the like are understood in a broad sense, for example, "connection" can be fixed connection, or detachable connection, or integral connection; can be mechanical connection, or electrical connection; can be directly connected, or indirectly connected through intermediate medium, can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0067] In the description of the specification, the relationship terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between the entities or operations. Moreover, the terms "include", "contain" or any other variant thereof are intended to cover non-exclusive inclusion, so that the process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or further includes elements inherent to such process, method, article or device. Without more limitations, the element defined by the statement "including a" does not exclude the presence of other identical elements in the process, method, article or device including the element.

[0068] The above description of the embodiments is to facilitate the understanding and application of the present technology for those skilled in the art, and those skilled in the art can easily make various modifications to these examples and apply the general principles described herein to other embodiments without creative labor. Therefore, the present application is not limited to the above embodiments, and the following modifications should be within the scope of protection: ① new technical solutions based on the technical solutions of the present application and combined with existing common knowledge, the technical effects produced by the new technical solutions do not exceed the technical effects of the present application; ② equivalent replacement of part of the features of the technical solutions of the present application using known technology, the technical effects produced are the same as the technical effects of the present application; ③ expandable based on the technical solutions of the present application, the essential content of the expanded technical solutions does not exceed the technical solutions of the present application; ④ equivalent transformation using the contents of the present application specification and drawings, direct or indirect application in other related technical fields.

Claims

1. A particle implantation apparatus for magnetic hyperthermia particles, comprising a frame, characterized in that, The frame body is further provided with: An implant tube fixedly connected with the frame body and guiding the particles to pass through; A pushing device installed on the frame body and applying a force to the particles to make them pass through the implant tube; A particle bin between the implant tube and the pushing device, one of the particles being located on the line connecting the implant tube and the pushing device when the particles are placed in the particle bin; The particles are provided with helical protrusions on the circumferential side along the length direction, and the pushing device comprises a threaded screw-in push rod which rotates and slides after being driven to rotate and push the particles along the length direction of the implant tube; The end of the threaded screw-in push rod in contact with the particles is provided with a buffer layer made of biocompatible flexible material, and at least one micro-protrusion is arranged on the side of the buffer layer in contact with the particles, and the micro-protrusion can abut against the side surface of the helical protrusion on the particle when the buffer layer is in contact with the particle.

2. The particle implanting apparatus of claim 1, wherein The pushing device comprises a micro motor, a transmission turbine and an electric control button, the electric control button is arranged on the frame body and starts and stops the micro motor, the transmission turbine is power-connected with the micro motor and drives the threaded screw-in push rod to screw in.

3. The particle implanting apparatus of claim 2, wherein A guide rod is further fixedly arranged on the frame body, an open-ended cavity is formed along the length direction of the axis of the threaded screw-in push rod, and the guide rod is inserted into the cavity and rotationally matched with the threaded screw-in push rod.

4. The particle implanting apparatus of claim 1, wherein The particle bin comprises a fixed seat fixedly arranged on the frame body and a bin body detachably connected with the fixed seat, and the particles are stored in the bin body.

5. The particle implant device of claim 4, wherein, The implant tube comprises an integral tube body and a head, the cross section of the head along the axis direction gradually increases, and the opening is adaptively connected with the fixed seat.

6. The particle implant device of claim 5, wherein, The inner walls of the tube body and the head are coated with a polytetrafluoroethylene coating.

7. The particle implant device of claim 1, wherein, The particle comprises a front end and a tail end along the length direction, the helical protrusion is located between the front end and the tail end, and a plurality of barbs made of polycaprolactone are fixed at the tail end of the particle, the free ends of the plurality of barbs are pre-tightened and fixed on an embolization sheet, and the embolization sheet is made of a water-soluble material with good biocompatibility; The end of the threaded screw-in push rod is recessed to form an avoiding cavity, and the barbs of the particle are accommodated in the avoiding cavity when the threaded screw-in push rod is in contact with the tail end of the particle.

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