Spleen protein peptide whitening and moisturizing mask liquid and preparation method thereof

Abstract

The invention provides spleen protein peptide whitening and moisturizing mask liquid and a preparation method thereof, and belongs to the technical field of cosmetics, the spleen protein peptide whitening and moisturizing mask liquid comprises an active component, a skin conditioner, an antioxidant, a surfactant, a protective agent, a thickener, a moisturizer, a preservative, essence and a solvent; the active ingredients comprise spleen protein peptide, apple stem cells, nicotinamide, arbutin, resveratrol and centella asiatica extract, and the molecular weight of the spleen protein peptide is less than 6000 Da. According to the spleen protein peptide whitening and moisturizing mask liquid and the preparation method thereof provided by the invention, the mask liquid has whitening and moisturizing effects and is good in absorption, fresh and cool in skin feeling and free of sticky and greasy feeling.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a spleen protein peptide whitening and moisturizing facial mask liquid and a preparation method thereof. Background Art

[0002] As we age, collagen loss leads to a series of skin problems, such as wrinkling and pigmentation. Therefore, it is crucial to properly supplement collagen to stimulate aging cells to secrete collagen again, improve the skin's self-repair and metabolism, and alleviate the symptoms of skin aging. Facial masks, as a common skincare product, can easily and efficiently replenish nutrients into the skin, achieving a balanced water and oil content, thereby achieving their desired effects. There are many types of facial masks on the market, each with its own distinct efficacy. Facial masks are often supplemented with amino acids, larger peptides, or collagen to enhance moisturizing, whitening, and anti-allergic properties. For example, Chinese patent publication CN114432166B, titled "A Moisturizing Facial Mask Containing Silicone-Extracted Tremella Polysaccharide," discloses a silicone-extracted moisturizing facial mask containing silicon-extracted Tremella polysaccharide. The mask provides timely and lasting moisturization, improving dry, rough, dull, and allergic skin. The mask comprises the following components by weight, calculated as 100% total mass: 0.1-5.0% silicon-extracted Tremella polysaccharide, 2.0-8.0% polyol moisturizer, 0.1-0.5% sodium polyacryloyldimethyltaurate, 0.1-1.0% 5D hyaluronic acid mixture, 0.5-5.0% complex amino acid mixture, 0.5-2.0% preservative, 0.003-3.0% fragrance, and deionized water to 100%.

[0003] For example, Chinese patent publication number CN110840793B, entitled "A Silk Protein Facial Mask and Its Preparation Method," discloses a silk protein facial mask and its preparation method. The silk protein facial mask comprises the following components in parts by weight: 30-50 parts of silk protein hydrolyzate, 5-13 parts of pomegranate peel extract, 3-8 parts of sweet clover extract, 1-5 parts of pyrrosia extract, 1-5 parts of mahonia extract, 0.5-2 parts of citronella oil, 0.5-1.5 parts of diisostearyl malate, 0.1-0.5 parts of decyl olive oil, 0.1-0.6 parts of triethanolamine, 0.1-0.5 parts of 1,2-hexanediol, 0.5-2 parts of butylene glycol, and 25-40 parts of water. The silk protein hydrolyzate is prepared by boiling silk in a sodium carbonate aqueous solution to degumming, followed by pressure hydrolysis of the degummed silk in a sodium hydroxide solution to obtain the silk protein hydrolyzate. However, although the amino acids and macromolecular proteins in the above two technical solutions can form a moisturizing layer, they are difficult to be absorbed by the skin and have problems such as poor absorbability and sticky skin feel. Summary of the Invention

[0004] In view of this, the present invention provides a spleen protein peptide whitening and moisturizing facial mask liquid and a preparation method thereof, so that the facial mask liquid has whitening and moisturizing effects while being well absorbed, leaving the skin feeling refreshed and non-sticky.

[0005] To achieve the above-mentioned purpose, the present invention provides a spleen protein peptide whitening and moisturizing facial mask liquid, comprising an active ingredient, a skin conditioner, an antioxidant, a surfactant, a protectant, a thickener, a moisturizer, a preservative, a fragrance and a solvent; the active ingredient is spleen protein peptide, apple stem cells, niacinamide, arbutin, resveratrol, and Centella asiatica extract, and the molecular weight of the spleen protein peptide is less than 6000 Da.

[0006] Optionally, the skin conditioner is allantoin; the antioxidant is ergothioneine; the surfactant is triethanolamine; and the protective agent is ectoine.

[0007] Optionally, the thickener is carbomer or sodium hydroxymethyl cellulose; the moisturizer is glycerin, butylene glycol or sodium hyaluronate.

[0008] Optionally, the preservative is methylparaben; and the solvent is water.

[0009] Optionally, the invention includes the following components in weight percentage: spleen protein peptide 0.3-0.7%, apple stem cell 0.03-0.07%, niacinamide 0.08-0.12%, arbutin 0.03-0.07%, resveratrol 0.03-0.07%, Centella asiatica extract 0.03-0.07%, allantoin 0.3-0.5%, ergothioneine 0.02-0.03%, triethanolamine 0.1-0.3%, ectoine 0.03-0.07%, carbomer 0.1-0.3%, sodium hydroxymethylcellulose 0.1-0.3%, glycerin 1-3%, butylene glycol 1-1.4%, sodium hyaluronate 0.03-0.07%, methylparaben 0.01-0.03%, essence 0.1-0.3%, and the balance is deionized water. The sum of the percentages of each component is 100%.

[0010] In order to achieve the above object, the present invention also provides a method for preparing a spleen protein peptide whitening and moisturizing facial mask liquid, comprising the following steps: S1. Weigh allantoin and carbomer, add a small amount of water and stir, then add triethanolamine, heat at a constant temperature until fully dissolved, and cool to room temperature for later use to obtain component A; S2. Weigh sodium hyaluronate, niacinamide, ergothioneine, ectoine, apple stem cells, arbutin powder, resveratrol, and Centella asiatica extract, add appropriate amount of water and mix thoroughly at room temperature to obtain component B; S3. Weigh methylparaben, add water, heat, stir and mix, and cool to room temperature for use to obtain component C; S4. Add glycerin, butylene glycol and sodium hydroxymethyl cellulose to component B, stir evenly, then add component A and component C and continue mixing to obtain a mixed material; S5, adding spleen protein peptide to the mixed material described in S4, mixing thoroughly and adding essence to obtain a transparent viscous solution; S6. Adjust the pH of the transparent viscous solution, perform two microfiltrations, add the remaining essence, and then sterilize to obtain the spleen protein peptide whitening and moisturizing facial mask liquid.

[0011] Optionally, the temperature of the constant temperature heating in S1 is 50-60°C; the temperature of the heating and stirring in S3 is 40-70°C.

[0012] Optionally, the pH value of the transparent viscous solution is adjusted to 5.5-7.

[0013] Optionally, the sufficient mixing in S5 is performed by using ultrasonic mixing, and the conditions for the ultrasonic mixing are a frequency of 20-40 kHz, a power of 100-300 W, a time of 10-15 min, and a temperature of 30-35° C.

[0014] Optionally, the two microfiltrations are first filtering through a 1 μm filter membrane and then filtering through a 0.45 μm filter membrane.

[0015] The above technical solution of the present invention includes at least the following beneficial effects: (1) The spleen protein peptide in the technical solution of the present invention is a small molecule active substance with a molecular weight of less than 6000 Da. This small molecule is easily absorbed and utilized by the skin. According to research, it has anti-ultraviolet, anti-aging, antioxidant and other effects. By adding Centella asiatica extract, niacinamide, allantoin and other substances, it can better play a synergistic role in combating skin problems. The spleen protein peptide mask liquid developed by the present invention can be well absorbed by the skin, and the skin feels refreshing and non-sticky.

[0016] (2) The present invention uses spleen protein peptides and ectoine in combination. By leveraging the "protective shell" of ectoine, it not only enhances the stress resistance of cells, enzymes, proteins and other biological molecules in the skin, but also can better repair skin tissue, improve skin defense capabilities, and replenish the moisture needed by the skin.

[0017] (3) The present invention uses niacinamide, Centella asiatica extract, allantoin, etc. as other active ingredients of the spleen protein peptide mask liquid, which directly acts on skin keratin to repair the skin barrier, promote cell growth, and make the skin smooth, white, tender, and highly moisturized. DETAILED DESCRIPTION

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field are within the scope of protection of the present invention.

[0019] Example 1 The invention provides a spleen protein peptide whitening and moisturizing facial mask liquid, which comprises the following components in percentage by weight: 0.5% spleen protein peptide, 0.05% apple stem cells, 0.1% niacinamide, 0.05% arbutin, 0.05% resveratrol, 0.05% Centella asiatica extract, 0.4% allantoin, 0.02% ergothioneine, 0.2% triethanolamine, 0.05% ectoine, 0.2% carbomer, 0.2% sodium hydroxymethylcellulose, 2% glycerin, 1.2% butylene glycol, 0.05% sodium hyaluronate, 0.02% methylparaben, 0.2% essence, and the balance being deionized water, wherein the sum of the percentages of the components is 100%.

[0020] The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid comprises the following steps: S1. Weigh allantoin and carbomer, add a small amount of water and stir, then add triethanolamine, heat at 50°C until fully dissolved, cool to room temperature and set aside to obtain component A; S2. Weigh sodium hyaluronate, niacinamide, ergothioneine, ectoine, apple stem cells, arbutin powder, resveratrol, and Centella asiatica extract, add appropriate amount of water and mix thoroughly at room temperature to obtain component B; S3. Weigh methylparaben and add water, heat at 70° C., stir and mix, and cool to room temperature for use to obtain component C; S4. Add glycerin, butylene glycol and sodium hydroxymethyl cellulose to component B, stir evenly, then add component A and component C and continue mixing to obtain a mixed material; S5. Add spleen protein peptide to the mixture described in S4, ultrasonicate for 15 min at a temperature of 30° C., a frequency of 30 kHz, and a power of 300 W, and then add 0.1% flavor after thorough mixing to obtain a transparent viscous solution; S6. Adjust the pH of the transparent viscous solution to 7, filter it through a 1 μm filter membrane, then filter it through a 0.45 μm filter, add the remaining essence, and then sterilize it to obtain the spleen protein peptide whitening and moisturizing facial mask liquid.

[0021] Example 2 The invention provides a spleen protein peptide whitening and moisturizing facial mask liquid, which comprises the following components in percentage by weight: 0.3% spleen protein peptide, 0.07% apple stem cells, 0.12% niacinamide, 0.07% arbutin, 0.03% resveratrol, 0.03% Centella asiatica extract, 0.5% allantoin, 0.03% ergothioneine, 0.3% triethanolamine, 0.07% ectoine, 0.1% carbomer, 0.3% sodium hydroxymethylcellulose, 1% glycerin, 1% butylene glycol, 0.03% sodium hyaluronate, 0.01% methylparaben, 0.3% essence, and the balance is deionized water, and the sum of the percentages of the components is 100%.

[0022] The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid comprises the following steps: S1. Weigh allantoin and carbomer, add a small amount of water and stir, then add triethanolamine, heat at 60°C until fully dissolved, cool to room temperature and set aside to obtain component A; S2. Weigh sodium hyaluronate, niacinamide, ergothioneine, ectoine, apple stem cells, arbutin powder, resveratrol, and Centella asiatica extract, add appropriate amount of water and mix thoroughly at room temperature to obtain component B; S3. Weigh methylparaben and add water, heat at 70° C., stir and mix, and cool to room temperature for use to obtain component C; S4. Add glycerin, butylene glycol and sodium hydroxymethyl cellulose to component B, stir evenly, then add component A and component C and continue mixing to obtain a mixed material; S5. Add spleen protein peptide to the mixture described in S4, ultrasonicate for 10 min at a temperature of 35° C., a frequency of 40 kHz, and a power of 200 W, and add 0.15% flavor after thorough mixing to obtain a transparent viscous solution; S6. Adjust the pH of the transparent viscous solution to 5.5, filter it through a 1 μm filter membrane, then filter it through a 0.45 μm filter, add the remaining essence, and then sterilize it to obtain the spleen protein peptide whitening and moisturizing facial mask liquid.

[0023] Example 3 The invention provides a spleen protein peptide whitening and moisturizing facial mask liquid, which comprises the following components in percentage by weight: 0.7% spleen protein peptide, 0.03% apple stem cells, 0.08% niacinamide, 0.03% arbutin, 0.07% resveratrol, 0.07% Centella asiatica extract, 0.3% allantoin, 0.03% ergothioneine, 0.1% triethanolamine, 0.03% ectoine, 0.3% carbomer, 0.1% sodium hydroxymethylcellulose, 3% glycerin, 1.4% butylene glycol, 0.07% sodium hyaluronate, 0.03% methylparaben, 0.1% essence, and the balance being deionized water, wherein the sum of the percentages of the components is 100%.

[0024] The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid comprises the following steps: S1. Weigh allantoin and carbomer, add a small amount of water and stir, then add triethanolamine, heat at 55°C until fully dissolved, cool to room temperature and set aside to obtain component A; S2. Weigh sodium hyaluronate, niacinamide, ergothioneine, ectoine, apple stem cells, arbutin powder, resveratrol, and Centella asiatica extract, add appropriate amount of water and mix thoroughly at room temperature to obtain component B; S3. Weigh methylparaben and add water, heat to 60° C., stir and mix, and cool to room temperature for use to obtain component C; S4. Add glycerin, butylene glycol and sodium hydroxymethyl cellulose to component B, stir evenly, then add component A and component C and continue mixing to obtain a mixed material; S5. Add spleen protein peptide to the mixture described in S4, ultrasonicate for 15 min at a temperature of 32° C., a frequency of 20 kHz, and a power of 100 W, and then add 0.05% flavor after thorough mixing to obtain a transparent viscous solution; S6. Adjust the pH of the transparent viscous solution to 6, filter it through a 1 μm filter membrane, then filter it through a 0.45 μm filter, add the remaining essence, and then sterilize it to obtain the spleen protein peptide whitening and moisturizing facial mask liquid.

[0025] The spleen protein peptide whitening and moisturizing facial mask liquid prepared in Example 1 was subjected to relevant tests: 1. Moisturizing performance test Small glass slides and medical breathable tapes were used as biological materials that simulated the stratum corneum and epidermis of the skin. The process of applying a facial mask on human skin was simulated by applying a facial mask liquid on the breathable tape. Two pieces of medical breathable tapes of the same size were taken and stuck on different glass slides. 0.5 g of facial mask liquid and deionized water were added respectively. The mask was spread evenly and the weight was recorded as M1. The mask was placed in a 25°C oven, taken out for about 10 minutes, and the weight was weighed again and recorded as M2. The moisturizing rate was calculated based on the weight ratio of the two times. The results are shown in Table 1. Moisturizing rate = M2 / M1×100% Table 1 Moisturizing performance test

[0026] As can be seen from Table 1, after comparing deionized water and the facial mask liquid prepared by the present invention and baking them at 25°C for 10 min, it was found that the moisturizing rate of the facial mask liquid was as high as 76.4%, which is more than twice that of deionized water, indicating that the spleen protein peptide facial mask liquid prepared by the present invention has a good moisturizing effect.

[0027] 2. Whitening performance test This test, based on the theory that fruit respiration promotes ripening, involves contacting the inner surface of a fresh potato with an apple to accelerate potato oxidation and shorten the time it takes for the potato to turn black and brown. Therefore, the present invention can be applied to the inner surface of a potato and the extent of its browning observed to determine whether the present invention has a whitening and antioxidant effect, and to what extent.

[0028] Fresh potatoes and apples were cut into slices of similar thickness and size (approximately 5 mm thick × 50 mm long × 50 mm wide). The potato slices were divided into three groups: a blank group, a control group, and a test group. Deionized water was evenly applied to the blank group (denoted as A); the control group was coated with an equal amount of a commercially available whitening facial mask (denoted as B); and the test group was treated with the facial mask solution of Example 1 of the present invention (denoted as C).

[0029] The potato slices and apple slices with the sample applied were placed crosswise in a plastic box at a ratio of 1:1, sealed with plastic wrap, and stored at room temperature for 30 minutes. The plastic wrap was then removed and the browning degree of the potato slices was observed and compared to compare the whitening and antioxidant effects of the samples. The results are shown in Table 2.

[0030] Table 2 Whitening performance test

[0031] From the comparison of the three colors in Table 2, it can be seen that the facial mask liquid prepared in the embodiment of the present invention has antioxidant and whitening effects.

[0032] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A spleen protein peptide whitening and moisturizing facial mask liquid, characterized in that, The invention comprises active ingredients, skin conditioners, antioxidants, surfactants, protective agents, thickeners, moisturizers, preservatives, fragrances and solvents; the active ingredients are spleen protein peptides, apple stem cells, niacinamide, arbutin, resveratrol and Centella asiatica extract, and the molecular weight of the spleen protein peptides is less than 6000 Da.

2. spleen protein peptide whitening and moisturizing facial mask liquid according to claim 1, is characterized in that, The skin conditioning agent is allantoin; the antioxidant is ergothioneine; the surfactant is triethanolamine; and the protective agent is ectoine.

3. spleen protein peptide whitening and moisturizing facial mask liquid according to claim 2, is characterized in that, The thickeners are carbomer and sodium hydroxymethylcellulose; the moisturizers are glycerin, butylene glycol and sodium hyaluronate.

4. The spleen protein peptide whitening and moisturizing facial mask liquid according to claim 3, wherein The preservative is methylparaben; and the solvent is water.

5. The spleen protein peptide whitening and moisturizing facial mask liquid according to claim 4, wherein The invention comprises the following components in percentage by weight: 0.3-0.7% of spleen protein peptide, 0.03-0.07% of apple stem cells, 0.08-0.12% of niacinamide, 0.03-0.07% of arbutin, 0.03-0.07% of resveratrol, 0.03-0.07% of Centella asiatica extract, 0.3-0.5% of allantoin, 0.02-0.03% of ergothioneine, 0.1-0.3% of triethanolamine, 0.03-0.07% of ectoine, 0.1-0.3% of carbomer, 0.1-0.3% of sodium hydroxymethylcellulose, 1-3% of glycerin, 1-1.4% of butylene glycol, 0.03-0.07% of sodium hyaluronate, 0.01-0.03% of methylparaben, 0.1-0.3% of essence, and the balance is deionized water. The sum of the percentages of the components is 100%.

6. A method for preparing a spleen protein peptide whitening and moisturizing facial mask liquid as described in any one of claims 1 to 5, characterized in that: The following steps are involved: S1. Weigh allantoin and carbomer, add a small amount of water and stir, then add triethanolamine, heat at a constant temperature until fully dissolved, and cool to room temperature for later use to obtain component A; S2. Weigh sodium hyaluronate, niacinamide, ergothioneine, ectoine, apple stem cells, arbutin powder, resveratrol, and Centella asiatica extract, add appropriate amount of water and mix thoroughly at room temperature to obtain component B; S3. Weigh methylparaben, add water, heat, stir and mix, and cool to room temperature for use to obtain component C; S4. Add glycerin, butylene glycol and sodium hydroxymethyl cellulose to component B, stir evenly, then add component A and component C and continue mixing to obtain a mixed material; S5, adding spleen protein peptide to the mixed material described in S4, mixing thoroughly and adding essence to obtain a transparent viscous solution; S6. Adjust the pH of the transparent viscous solution, perform two microfiltrations, add the remaining essence, and then sterilize to obtain the spleen protein peptide whitening and moisturizing facial mask liquid.

7. The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid according to claim 6, wherein The temperature of the constant temperature heating in S1 is 50-60°C; the temperature of the heating and stirring in S3 is 40-70°C.

8. The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid according to claim 6, wherein The pH value of the transparent viscous solution is adjusted to 5.5-7.

9. the preparation method of spleen protein peptide whitening and moisturizing facial mask liquid according to claim 6, is characterized in that, The sufficient mixing in S5 is performed by ultrasonic mixing, and the conditions for the ultrasonic mixing are a frequency of 20-40 kHz, a power of 100-300 W, a time of 10-15 min, and a temperature of 30-35° C.

10. The preparation method of spleen protein peptide whitening and moisturizing facial mask liquid according to claim 6, wherein The two microfiltrations are firstly filtered through a 1 μm filter membrane and then filtered through a 0.45 μm filter membrane.

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