Application of parabacteroides dielsii outer membrane vesicles in preparation of medicines for treating hepatic fibrosis

By preparing and characterizing the outer membrane vesicles of Parabens de Bacteroides (OMV), its therapeutic potential is verified in the liver fibrosis model, solving the problem of limited efficacy of existing therapeutic strategies and achieving significant improvement in liver pathological structure and functional recovery.

CN120459144APending Publication Date: 2025-08-12SUN YAT SEN UNIV
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Patent Information

Application Number
CN202510800697.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-16
Publication Date
2025-08-12

AI Technical Summary

Technical Problem

The existing treatment methods for liver fibrosis such as anti-inflammatory drugs and antioxidants have limited efficacy and great side effects, and lack effective new therapeutic strategies. The application of Parabenstralopid cervical (OMV) in liver fibrosis therapy has not been fully explored.

Method used

Prepare and characterize the outer membrane vesicles (OMV) of Parabens Deliveri, and verify its therapeutic potential in the CCl4-induced liver injury and fibrosis model. By reversing liver injury and oxidative stress, it reduces bilirubin rise, improves antioxidant indicators, and reduces collagen deposition.

Benefits of technology

OMV significantly improves liver histopathological structure, reduces collagen deposition, and restores liver function-related biochemical indicators, shows better efficacy than commonly used anti-fibrotic drugs, and has good biological activity and therapeutic potential.

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Abstract

The invention discloses an application of parabacteroides dielsii outer membrane vesicles in preparation of a medicine for treating hepatic fibrosis. The invention successfully prepares, extracts and systematically characterizes the outer membrane vesicles (OMV) derived from parabacteroides dielsii for the first time, and verifies the therapeutic potential of the OMV in a CCl4-induced liver injury and fibrosis model. Experimental results show that the OMV intervention significantly improves the pathological structure of liver tissue and significantly reduces collagen deposition, so that the OMV intervention is expected to become a novel treatment strategy for hepatic fibrosis.
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