Composition for relieving chronic pain related depressive mood and application thereof

Abstract

The invention discloses a composition for relieving chronic pain related depressive mood. The composition is mainly prepared from the following traditional Chinese medicinal materials in parts by weight: 5-30 parts of borneol, 5-30 parts of musk, 50-100 parts of liquorice, 50-100 parts of burdock, 50-100 parts of gardenia kernel, 20-60 parts of calculus bovis, 50-100 parts of acorus gramineus and 50-100 parts of radix curcumae. Molecular mechanisms and potential treatment effects of borneol powder for treating chronic pain related depressive mood are researched by a modern scientific method, and safety and effectiveness of medicines are evaluated by pharmacodynamic and toxicological evaluation and animal experiments, so that the traditional Chinese medicine composition capable of effectively relieving chronic pain related depressive mood is provided.

Description

Technical Field

[0001] The present invention belongs to the field of medical treatment, and specifically relates to a composition for relieving chronic pain-related depression and its use. Background Art

[0002] Chronic pain is a major public health problem. The 2020 China Pain Medicine Development Report pointed out that there are more than 300 million chronic pain patients in my country, and the number is increasing at a rate of 10 to 20 million per year. Similarly, depression, as one of the most common mental disorders, is the leading cause of disability worldwide and the main cause of the global disease burden. Clinically, patients with chronic pain often suffer from depression[3]. Epidemiological studies have shown that patients with chronic pain and depression account for 50% of the total number of chronic pain patients. Depression can aggravate the patient's perception of chronic pain, leading to a vicious cycle of mutual influence between chronic pain and depression, and eventually developing into a difficult-to-treat disease[5]. However, since the pathogenesis of chronic pain-related depression is still unclear, the current treatment for chronic pain-related depression is still mainly based on pain treatment and common antidepressant drugs, and the treatment effect is not ideal. Therefore, further exploring the pathogenesis of chronic pain-related depression and finding new drug targets are particularly important for blocking the occurrence of chronic pain-related depression.

[0003] Traditional Chinese medicine (TCM) is gaining increasing attention in the prevention and treatment of pain and depression due to its advantages, such as minimal toxicity and side effects and multi-target effects. Borneol (Borneol) Powder, from the "Taiping Shenghui Fang," boasts the effects of invigorating the mind, dissipating heat and relieving pain, and improving eyesight and removing cataracts. The composition and raw material sources of the Borneol (Borneol) Powder, as described in Volume 85 of the book, are as follows: Borneol (Borneol): 1.5 g, finely ground; Musk: 1.5 g, finely ground; Licorice: 7.5 g, roasted until slightly red, then file; Burdock Fruit: 7.5 g, lightly stir-fried; Gardenia Seed: 7.5 g; Bezoar: 4 g, finely ground; Ma Ya Xiao: 7.5 g, finely ground; Curcuma: 7.5 g. However, prior art suggests that Borneol (Borneol) Powder can alleviate depression associated with chronic pain. Currently, borneol and its compound preparations have been used clinically to treat neuropathic pain. Zhang Dan et al.'s research suggests that borneol has an analgesic effect on incisional pain in patients undergoing spinal tumor surgery. Preclinical studies have also shown that the traditional Chinese medicine borneol can effectively alleviate postoperative pain in rats with plantar incision pain. Zhao Yuqian et al. found that borneol can reduce nociceptive signals transmitted to the CeA by nociceptors at the site of injured tissue, suppressing acute pain from hindlimb puncture wounds in rats. Musk, the dried secretion from the musk sac of male musk deer (Cervidae), has the effects of invigorating the mind, promoting blood circulation and menstruation, and reducing swelling and relieving pain. Musk ointment is effective and safe in relieving knee pain in patients diagnosed with cold-dampness arthralgia syndrome according to Traditional Chinese Medicine. Studies have also shown that musk moxibustion can regulate pain mediators and neurotransmitter levels, alleviate pain intensity, suppress depression, and improve clinical symptoms in patients with pancreatic cancer. However, we have found that the combined use of borneol and musk alone is insufficient, affecting the success rate of treatment. Summary of the Invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for relieving depression associated with chronic pain based on the existing technology.

[0005] The purpose of the present invention can be achieved by the following measures: A composition for relieving chronic pain-related depression is mainly prepared from the following Chinese medicinal materials in parts by weight: 5-30 parts of borneol (borneol), 5-30 parts of musk, 50-100 parts of liquorice, 50-100 parts of burdock fruits, 50-100 parts of gardenia seeds, 20-60 parts of bezoar, 50-100 parts of horsetail root, and 50-100 parts of turmeric.

[0006] In a preferred embodiment, the composition of the present invention is mainly prepared from the following Chinese medicinal materials in parts by weight: 10-20 parts of borneol (borneol), 10-20 parts of musk, 60-90 parts of licorice, 60-90 parts of burdock fruits, 60-90 parts of gardenia seeds, 30-50 parts of bezoar, 60-90 parts of horsetail shavings, and 60-90 parts of turmeric.

[0007] In a more preferred embodiment, the composition of the present invention is mainly made of the following Chinese medicinal materials in parts by weight: 12-18 parts of borneol (borneol), 12-18 parts of musk, 70-80 parts of licorice, 70-80 parts of burdock fruits, 70-80 parts of gardenia seeds, 35-45 parts of bezoar, 70-80 parts of horsetail shavings, and 70-80 parts of turmeric.

[0008] In another more preferred embodiment, the composition of the present invention is mainly prepared from the following Chinese medicinal materials in parts by weight: 14-16 parts of borneol (borneol), 14-16 parts of musk, 73-78 parts of licorice, 73-78 parts of burdock fruits, 73-78 parts of gardenia kernels, 38-42 parts of bezoar, 73-78 parts of horsetail shavings, and 73-78 parts of turmeric.

[0009] In another more preferred embodiment, the composition of the present invention is mainly prepared from the following Chinese medicinal materials in parts by weight: 15 parts of borneol (borneol), 15 parts of musk, 75 parts of licorice, 75 parts of burdock fruit, 75 parts of gardenia kernel, 40 parts of bezoar, 75 parts of horsetail root, and 75 parts of turmeric.

[0010] The composition of the present invention may further include pharmaceutically acceptable excipients.

[0011] The composition of the present invention can be prepared into various dosage forms according to existing traditional Chinese medicine preparation methods. In one embodiment, the dosage forms prepared therefrom include but are not limited to powders, decoctions, pills, ointments, pills, tablets, capsules or granules.

[0012] The present invention provides a method for preparing the above-mentioned Chinese medicine composition, which specifically comprises the following steps: (1) Clean and cut each Chinese herbal medicine slice separately; (2) Grind bezoar, borneol (borneol), and musk into powder separately and sieve; (3) Grind the licorice root, burdock fruit, gardenia seed, scutellaria baicalensis and turmeric into fine powder; (5) Mix the crushed Chinese medicine powder with the finely ground bezoar, borneol (borneol) and musk powder until fully uniform; (5) The mixed powder is sieved to prepare a preparation.

[0013] In step (1), cut the licorice into small pieces, stir-fry the burdock seeds, roast the licorice until it turns slightly red, and then grind it.

[0014] The composition of the present invention can be used in the preparation of medicines for alleviating depression associated with chronic pain.

[0015] The present invention provides an application of a traditional Chinese medicine composition in the preparation of a medicament for alleviating chronic pain-related depression, wherein the traditional Chinese medicine composition is mainly prepared from the traditional Chinese medicines mentioned above in parts by weight.

[0016] In one embodiment, such as in the Examples, the chronic pain is caused by selective injury to the sciatic nerve.

[0017] Although prior art suggests that borneol (bornol) and musk can alleviate disease-induced neuralgia and depression, using each herb alone can lead to drug resistance in pathogens or lesions, and the actual therapeutic effect remains insufficient. The use of multiple ingredients in the present invention's formulation can delay the development of drug resistance and improve the success rate of treatment. Furthermore, borneol (bornol) powder, through the synergistic action of multiple ingredients, can more comprehensively improve the pathological condition.

[0018] In the compositions of the present application: Main Ingredient: Borneol (Borneol). Core Function: Revitalizes the mind, clears heat, calms the nerves, and regulates Qi to break the vicious cycle of pain and depression. Aromatic and penetrating, it unblocks the meridians and revitalizes the orifices. Borneol (Borneol) has a fragrant aroma and penetrating properties, reaching the head and eyes and unclogging the meridians. It can quickly clear local meridian blockages caused by chronic pain (such as qi stagnation, blood stasis, and phlegm-dampness), alleviating pain caused by obstruction. Effect on Depression: Unblocking the meridians regulates Qi, restoring the liver's function of regulating qi, and alleviating the stagnation of liver qi and the resulting depression caused by chronic pain.

[0019] Auxiliary Herb: Musk. Core Function: Enhances the power of opening the orifices, promotes blood circulation and menstruation to relieve pain, and regulates Qi and blood to soothe the liver. It promotes blood circulation and menstruation, relieves pain and relieves depression. Its "blood circulation and menstruation" effect can improve local blood circulation (such as blood stasis in chronic headaches and joint pain), alleviating pain intensity. Pain relief weakens the body's stress response and inhibits the pathological process of liver depression transforming into fire, thereby reducing depression (modern research shows that pain control can reduce the stress response of the limbic system and improve mood regulation). It also soothes the liver and regulates Qi, freeing up emotions. Musk's kinetic properties can help regulate liver Qi, addressing the pathological mechanism of chronic pain damaging the liver by regulating Qi and alleviating depressive symptoms in patients with chronic pain.

[0020] Adjuvant: Curcuma. Core functions: Regulating Qi, relieving depression, promoting blood circulation, and removing blood stasis, addressing both the symptoms and the root causes of pain-depression comorbidities. It promotes Qi circulation and relieves depression, addressing the root causes of Qi stagnation. Curcuma's "pungent dispersing and bitter descending" properties are known to soothe the liver and regulate Qi (as described in the "Compendium of Materia Medica" as "relieving depression and unblocking stagnation"). For chronic pain patients experiencing Qi stagnation caused by long-term pain (e.g., depression due to liver depression and Qi stagnation), it can directly alleviate symptoms such as chest and flank distension and depression. Its "cooling blood and clearing the heart" properties can also clear the heat that can transform into fire from liver depression (manifested as irritability, insomnia, and dreaminess), disrupting the pathological chain of "Qi stagnation → transformation into fire → disturbing the heart."

[0021] Adjuvant: Coptis chinensis. Core function: Clears the heart, purges fire, relieves restlessness, and calms the mind. It targets depression caused by "heat disturbing the mind." Clears heart fire, calms the mind, and soothes the spirit. Coptis chinensis is highly bitter and cold, specifically entering the Heart Meridian. It is primarily used to treat depressive symptoms (such as restlessness, insomnia, mouth sores, and a red tongue tip) caused by "excessive heart fire" in patients with chronic pain. Clearing heart fire calms the mind, significantly alleviating symptoms such as irritability and anxiety. Clears heat, dries dampness, and resolves phlegm and relieves depression. For patients with "phlegm-heat disturbing the mind" (chronic pain accompanied by endogenous phlegm and dampness, accompanied by a yellow, greasy tongue coating and a slippery, rapid pulse), Coptis chinensis can clear phlegm and resolve heat, eliminating the obstruction of the mind caused by phlegm (which can block Qi flow and lead to emotional dullness and slow thinking). Combined with aromatic herbs that stimulate the orifices (such as borneol and musk), it can enhance the efficacy of "resolving phlegm, invigorating the orifices, and relieving depression."

[0022] Guiding Herb: Licorice. Core Function: Harmonizing the properties of the various herbs, tonifying the spleen and replenishing Qi, relieving pain, and promoting emotional balance. Licorice harmonizes the various herbs and relieves pain. Its sweet and warm nature can mitigate the harsh, dry properties of aromatic herbs like borneol (bornol) and musk, preventing the depletion of Qi and Yin (chronic pain sufferers often have underlying Qi and blood deficiency, requiring both attacking and replenishing). Furthermore, its ability to relieve pain and relieve muscle spasms (such as chronic headaches and abdominal pain). Pain relief reduces the body's secretion of stress hormones (such as cortisol), improving emotional stability. It nourishes the heart and calms the mind, harmonizing emotions. Licorice alone (such as in Licorice, Wheat, and Jujube Decoction) has calming properties, alleviating symptoms of heart Qi deficiency, such as sadness, urge to cry, and palpitations. When combined with the heat-clearing and orifice-opening herbs in the formula, it offers a balanced combination of strength and gentleness, enhancing the overall calming and depression-relieving effects.

[0023] This invention utilizes modern scientific methods to investigate the molecular mechanisms and potential therapeutic effects of borneol (bornol) powder in treating chronic pain-related depression. Pharmacodynamic and toxicological evaluations, as well as animal experiments, are used to assess the drug's safety and efficacy. This invention provides a traditional Chinese medicine composition that can effectively alleviate chronic pain-related depression. The invention also provides a novel use for this traditional Chinese medicine composition. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The mechanical pain threshold and cold pain sensitivity tests of four groups of mice in the embodiment of the present invention are as follows; Figure 2 This is the depressive-like behavior test of four groups of mice in the embodiment of the present invention; Figure 3 HE staining was used in the examples of the present invention to observe the effects of borneol (borneol) powder on the morphology of the heart, liver and kidney. DETAILED DESCRIPTION

[0025] The present invention will be further described below with reference to the embodiments and drawings, but the protection scope of the present invention is not limited to the following embodiments.

[0026] Example 1 A traditional Chinese medicine composition for relieving depression associated with chronic pain, comprising the following raw materials, measured by mass: 15g borneol (borneol), 15g musk, 75g liquorice, 75g burdock fruit, 75g gardenia kernel, 40g bezoar, 75g horsetail root, and 75g turmeric.

[0027] The preparation method comprises the following steps: (1) Clean and cut the Chinese herbal medicines such as licorice, burdock, gardenia, horsetail, and turmeric separately. For example, licorice needs to be cut into small pieces, and burdock needs to be lightly fried.

[0028] (2) Grind bezoar, borneol (borneol), and musk into very fine powder respectively, sieve them and set aside to ensure that they have a fine texture and are easy to mix evenly.

[0029] (3) Place the processed Chinese herbal medicine slices such as licorice, burdock fruit, gardenia seed, horsetail schizonepeta, and turmeric in a grinder and grind them into fine powder.

[0030] (4) Mix the crushed Chinese medicine powder with the previously finely ground bezoar, borneol (borneol), and musk powder, put them into a mixer, and start the low-speed stirring mode to ensure that the ingredients are fully and evenly mixed to ensure stable efficacy.

[0031] (5) Sieve the mixed powder to remove larger particles and impurities to make the powder more fine and uniform.

[0032] (6) The divided doses of powder should be packaged into powders to protect them from moisture, contamination, and deterioration. The packaging materials should be non-toxic, harmless, and breathable.

[0033] Example 2 A traditional Chinese medicine composition for relieving depression associated with chronic pain, comprising the following raw materials, measured by mass: 15g borneol (borneol), 15g musk, 78g liquorice, 74g burdock fruit, 76g gardenia kernel, 38g bezoar, 74g horsetail root, and 76g turmeric.

[0034] The preparation method is the same as that in Example 1.

[0035] Example 3 A traditional Chinese medicine composition for relieving depression associated with chronic pain, comprising the following raw materials, measured by mass: 14g borneol (borneol), 16g musk, 74g liquorice, 76g burdock fruit, 74g gardenia kernel, 42g bezoar, 76g horsetail root, and 74g turmeric.

[0036] The preparation method is the same as that in Example 1.

[0037] Neuropathic pain model preparation and animal experiments 1. Preparation and Grouping of Neuropathic Pain Models: C57BL / 6J mice (8-10 weeks old) were randomly divided into a sham-operated group (Sham) and a sparingly injured sciatic nerve (SNI) group. To prepare the SNI model, the animals were anesthetized with an intraperitoneal injection of 2% sodium pentobarbital. A transverse skin incision was performed on the left thigh to expose the underlying nerves. The tibial and common peroneal nerves were ligated and transected, while the sural nerve was preserved. In the sham group, only the sciatic nerve was exposed without ligation.

[0038] 2. Behavioral experiments a. Forced swim test Before the experiment began, mice were placed in a 30×45 cm transparent glass tank at 25°C for 15 minutes of pre-acclimatization. The following day, the same conditions were repeated, with a total forced swimming time of 6 minutes. The duration of immobility within 5 minutes was recorded, and the entire experiment was recorded with a video camera. After each experiment, the animals were dried and their water was changed.

[0039] b. Sugar water preference experiment Each mouse was placed in a separate cage for the experiment. During the first 24 hours, the mice were provided with two bottles of 1% sucrose solution. During the second 24 hours, they were given a bottle of 1% sucrose solution and a bottle of normal drinking water. After fasting for 23 hours without food or water, they were given a bottle of 1% sucrose solution and a bottle of drinking water. We measured the weight of the two drinking bottles before the start and observed the mice's drinking within 1 hour. Based on these data, we determined the animals' preference for sugar water: Sugar water preference rate (%) = sugar water consumption / (normal drinking water consumption + sugar water consumption) × 100% c. Open field test Mice were placed in the behavioral chamber for acclimatization 24 hours before the experiment. Before the experiment began, mice were securely placed in the center of the chamber, with their heads generally facing the same direction. A camera was used to record the mice's movements for 5 minutes, and data was collected using ANY-maze software. After each mouse was tested, the environment was cleaned with alcohol before the next animal was placed in the chamber for the experiment.

[0040] d. Elevated plus maze test Animals were placed in the experimental room 30 minutes in advance to allow them to acclimate to the different environments. The apparatus consisted of two open arms and two closed arms. Before the experiment began, mice were placed in the central area, and their movements were recorded using a camera for 5 minutes. The total number of entries into the open and closed arms was also recorded. After each mouse was tested, the environment was cleaned with alcohol before the next animal was introduced.

[0041] Experimental Description Thirty SPF C57 mice weighing 18-22 g were acclimated for 5-7 days and then randomly divided into five groups of six: a normal control group, a model group, a borneol-musk combination group, a low-dose Chinese herbal ointment group, and a high-dose Chinese herbal ointment group. The SNI model was established; the control group only had skin exposed without nerve ligation.

[0042] Mice in the control and SNI groups were gavaged with dimethyl sulfoxide (DMSO). Mice in the combination group were gavaged with a 30 mg / kg borneol-musk suspension (15 g borneol (borneol) and 15 g musk were finely ground into a powder, mixed, and then suspended in DMSO). Mice in the low-dose group were gavaged with 20 mg / kg of the borneol (borneol) powder obtained in Example 1, and mice in the high-dose group were gavaged with 30 mg / kg of the borneol (borneol) powder obtained in Example 1, once daily for 14 consecutive days. Doses in the combination, low-dose, and high-dose groups were calculated by weight of the medicinal materials.

[0043] The pain behavior of mice was detected 1 day before surgery and 7, 14, 21, and 28 days after surgery. The forced swim test and sugar water preference test were used to analyze the depressive-like behavior of mice 28 days after surgery. The open field test and elevated plus maze test were used to observe and analyze the spontaneous behavior of mice.

[0044] 3. Original Results Effects on mechanical pain in SNI-induced depression model mice. The results of mechanical pain threshold measurements of each group are shown in Table 1: Table 1 Note: In the table, # indicates P < 0.05 compared with the normal control group; * indicates P < 0.05 compared with the model group.

[0045] As can be seen from Table 1, starting from the 7th day after modeling, SNI mice showed obvious mechanical pain sensitivity (P<0.05), indicating that the chronic pain model was successfully established. The mechanical pain of mice in the combined drug group did not change significantly on day 28 (P>0.05), while the mechanical pain sensitivity of mice in the low-dose and high-dose groups decreased (P<0.05).

[0046] Effects of cold pain on SNI-induced depression model mice. The cold pain scores of each group are shown in Table 2.

[0047] Table 2 As shown in Table 2, cold pain scores in SNI mice increased starting on day 7 after modeling (P < 0.05), indicating successful chronic pain modeling. Drug treatment was initiated 14 days later, and although cold pain scores decreased after treatment on day 28, this was not statistically significant (P > 0.05).

[0048] Effects on the immobility time of SNI-induced depression model mice. The results of the forced swimming test for each group are shown in Table 3.

[0049] Table 3 Note: In the table, # indicates P < 0.05 compared with the normal control group; * indicates P < 0.05 compared with the model group.

[0050] As shown in Table 3, the model group mice spent significantly longer immobile time in the water than the control group (P < 0.05), indicating that the chronic pain-related depression mouse model was successfully established. In the combined medication groups, the low- and high-dose Chinese medicine groups spent significantly less immobility time in the water than the model group (P < 0.05).

[0051] Effects on the immobility time of SNI-induced depression model mice. The results of the tail suspension test for each group are shown in Table 4.

[0052] Table 4 Note: In the table, # indicates P < 0.05 compared with the normal control group; * indicates P < 0.05 compared with the model group.

[0053] As shown in Table 4, the immobility time of mice in the model group during the tail suspension test was significantly longer than that of the normal control group (P < 0.05), indicating that the chronic pain-related depression mouse model was successfully established. The immobility time of mice in the combination drug group did not change significantly (P > 0.05). However, the immobility time of mice in the low- and high-dose Chinese medicine groups during the tail suspension test was significantly lower than that of the model group (P < 0.05).

[0054] Effects on sucrose preference in SNI-induced depression model mice. The results of sucrose preference test of mice in each group are shown in Table 5.

[0055] Table 5 As shown in Table 5, the model group mice showed a significantly lower preference for sugar water in the sugar water experiment than the normal control group (P < 0.05), indicating that SNI mice exhibit depressive-like behavior. The sugar water preference rate of mice in the combination drug group did not change significantly (P > 0.05). However, the sugar water preference rate of mice in the low- and high-dose Chinese medicine groups was significantly higher than that of the model group (P < 0.05).

[0056] 4. Experimental Results 1. Observe the effect of borneol (borneol) powder on pain in mice with chronic pain-related depression To investigate the effect of borneol (borneol) powder on pain behavior in SNI mice, we administered DMSO (a negative control) by gavage on day 14 after SNI surgery. The mice were randomly divided into the SNI + DMSO group, the SNI + 20 mg / kg group, and the SNI + 30 mg / kg group. After 14 consecutive days of administration, cold and mechanical allodynia were measured on day 28 after surgery. We found that administration of borneol (borneol) powder significantly increased the mechanical pain threshold (MWT) of the mice (P < 0.05). While sensitivity to cold pain was reduced, this was not statistically significant (P < 0.05). This suggests that borneol (borneol) powder can alleviate pain behavior in mice.

[0057] Figure 1 Results showed changes in mechanical pain threshold and cold pain sensitivity in the SNI+DMSO, SNI+20mg / kg, and SNI+30mg / kg groups compared with the sham group. All data are expressed as mean ± SEM, n = 6, *P < 0.05, **P < 0.01.

[0058] 2. Observing the Effect of Borneol (Borneol) Powder on Depression in Mice with Chronic Pain-Related Depression To investigate the effect of borneol (borneol) powder on depression in SNI mice, we used forced swim, tail suspension, and sucrose water tests to observe behavioral changes in mice 28 days after surgery. Compared with the SNI + DMSO group, the sham + 20 mg / kg and sham + 30 mg / kg groups showed a shorter immobility time in the forced swim test and a significantly reduced immobility time in the tail suspension test. Furthermore, the sucrose water preference rate was significantly increased in the sham + 20 mg / kg and 30 mg / kg groups compared with the SNI + DMSO group, indicating that depression in the sham + 20 mg / kg and 30 mg / kg groups was alleviated, further demonstrating that borneol (borneol) powder can improve depression in mice with chronic pain-related depression.

[0059] Figure 2Results show the results of the forced swim test, tail suspension test, and cold sugar water preference test in four groups of mice. All data are expressed as mean ± SEM, n = 6, *P < 0.05, **P < 0.01.

[0060] 3. Observation of the toxic effects of borneol (borneol) powder on the heart, liver, and kidneys of mice To investigate the toxic effects of borneol (or borneol) powder on mice, we used HE staining to examine changes in the hearts, livers, and kidneys of four groups of mice. We found no significant changes in the hearts, livers, or kidneys after administration of borneol (or borneol) powder. This suggests that borneol (or borneol) powder does not cause toxic reactions in mice.

[0061] Figure 3 The results showed that there were no significant changes in the heart, liver, and kidney structures of the four groups of mice, indicating that oral administration of borneol (borneol) powder did not cause toxicity to the mice.

[0062] The above-described embodiments merely illustrate several implementations of the present invention, and while their descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A composition for relieving depression associated with chronic pain, characterized in that The medicine is mainly prepared from the following Chinese medicinal materials in parts by weight: 5-30 parts of borneol, 5-30 parts of musk, 50-100 parts of liquorice, 50-100 parts of burdock fruit, 50-100 parts of gardenia kernel, 20-60 parts of bezoar, 50-100 parts of horsetail root and 50-100 parts of turmeric.

2. The composition according to claim 1, characterized in that The medicine is mainly prepared from the following Chinese medicinal materials in parts by weight: 10-20 parts of borneol, 10-20 parts of musk, 60-90 parts of liquorice, 60-90 parts of burdock fruit, 60-90 parts of gardenia kernel, 30-50 parts of bezoar, 60-90 parts of horsetail root and 60-90 parts of turmeric.

3. The composition according to claim 2, characterized in that The medicine is mainly prepared from the following Chinese medicinal materials in parts by weight: 14-16 parts of borneol, 14-16 parts of musk, 73-78 parts of liquorice, 73-78 parts of burdock fruit, 73-78 parts of gardenia kernel, 38-42 parts of bezoar, 73-78 parts of horsetail root and 73-78 parts of turmeric.

4. The composition according to claim 1, characterized in that It includes pharmaceutically acceptable excipients.

5. The composition according to claim 1, characterized in that The dosage form prepared by the invention is powder, decoction, pill, paste, pill, tablet, capsule or granule.

6. A method for preparing the composition according to claim 1, characterized in that It includes the following steps: (1) Clean and cut each Chinese herbal medicine slice separately; (2) Grind bezoar, borneol and musk into powder respectively and sieve; (3) Grind the licorice root, burdock fruit, gardenia seed, scutellaria baicalensis and turmeric into fine powder; (4) Mix the crushed Chinese medicine powder with the finely ground bezoar, borneol and musk powder until fully uniform; (5) The mixed powder is sieved to prepare a preparation.

7. The preparation method according to claim 6, characterized in that In step (1), cut the licorice into small pieces, stir-fry the burdock seeds, roast the licorice until it turns slightly red, and then grind it.

8. Use of the composition according to any one of claims 1 to 5 in the preparation of a medicament for alleviating depression associated with chronic pain.

9. Use of a traditional Chinese medicine composition in the preparation of a medicament for relieving depression associated with chronic pain, wherein the traditional Chinese medicine composition is mainly prepared from the traditional Chinese medicine according to any one of claims 1 to 3 in parts by weight.

10. The use according to claim 9, characterized in that The chronic pain is caused by selective damage to the sciatic nerve.

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