Multi-target synergistic conditioning traditional Chinese medicine composition and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for multi-target synergistic conditioning and a preparation method thereof, the traditional Chinese medicine composition comprises astragalus membranaceus, poria cocos, hawthorn, fingered citron, raspberry, rhizoma polygonati, dried ginger, turmeric, pericarpium citri reticulatae, radix polygonati officinalis, radix puerariae, peach kernel, cinnamon, mulberry leaf and chrysanthemum. The traditional Chinese medicine composition adopts compatibility of medicinal and edible medicinal materials, can effectively condition various diseases such as constipation, ulcerative colitis, haemorrhoids, obesity, sleep disorder and the like through a multi-target synergistic effect, realizes multiple purposes by one medicine, meets the requirements of comprehensive treatment of patients, is high in safety, avoids dependency and side effects possibly generated by western medicines, and has a wide application prospect. Meanwhile, compared with a traditional complex traditional Chinese medicine formula, the traditional Chinese medicine composition is higher in pertinence, remarkable in curative effect and capable of accurately acting on the root causes of diseases, the preparation method is easy and convenient to operate, the stability and consistency of the product quality are guaranteed, and application and popularization of the product are facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a multi-target synergistic conditioning traditional Chinese medicine composition and a preparation method thereof. Background Art

[0002] Traditional Chinese medicine slices are made by combining multiple herbs in specific combinations to prevent and treat illness. Given the wide variety of genders, ages, and illnesses, there are also a wide variety of herbs used in these combinations.

[0003] In the current medical field, there are many deficiencies in the existing treatments for conditions such as constipation, ulcerative colitis, hemorrhoids, obesity, and sleep disorders. Although Western medicine may have certain effects in the short term, it is often accompanied by dependence problems. Long-term use may also cause side effects such as intestinal flora imbalance and liver and kidney damage. Traditional Chinese medicine formulas are complex in composition, and some formulas are not effective enough or are not targeted enough for specific conditions. At the same time, it is relatively rare to find a plan that can jointly regulate multiple conditions at the same time. There is a lack of systematic intervention ideas, and it is difficult to meet the patients' needs for comprehensive treatment. To this end, a multi-target synergistic regulating Chinese medicine composition and a preparation method thereof are introduced. Summary of the Invention

[0004] In response to the deficiencies in the prior art, the present invention provides a multi-target synergistic conditioning Chinese medicine composition and a preparation method thereof, which has the advantages of a combination of medicinal and edible ingredients and multi-target synergistic conditioning, and solves the problems raised by the above-mentioned background technology.

[0005] The present invention provides the following technical solution: a traditional Chinese medicine composition for multi-target synergistic conditioning, wherein the traditional Chinese medicine composition comprises: astragalus, poria, hawthorn, bergamot, raspberry, polygonatum, dried ginger, turmeric, tangerine peel, polygonatum, kudzu root, peach kernel, cinnamon bark, mulberry leaf, and chrysanthemum.

[0006] Preferably, it is composed of the following components in weight percentage: 10% to 15% of Astragalus, 5% to 7% of Poria, 5% to 7% of Hawthorn, 5% to 7% of Buddha's hand, 5% to 7% of Raspberry, 5% to 7% of Polygonatum, 5% to 7% of Dry Ginger, 5% to 7% of Turmeric, 5% to 7% of Tangerine Peel, 5% to 7% of Polygonatum, 10% to 15% of Pueraria, 5% to 7% of Peach Kernel, 5% to 7% of Cinnamon, 5% to 7% of Mulberry Leaf, and 5% to 7% of Chrysanthemum.

[0007] Preferably, it is composed of the following components in weight percentage: 12% astragalus, 6% poria, 6% hawthorn, 6% bergamot, 6% raspberry, 6% polygonatum, 6% dried ginger, 6% turmeric, 6% tangerine peel, 6% polygonatum, 12% kudzu root, 6% peach kernel, 6% cinnamon, 6% mulberry leaf, and 6% chrysanthemum.

[0008] Preferably, the weight ratio of the astragalus root to the kudzu root is 1:1.

[0009] Preferably, the method comprises the following steps: Step S1: raw material pretreatment; Step S2: active ingredient extraction; Step S3: concentration and compounding; Step S4: Molding and packaging.

[0010] Preferably, step S1 specifically includes: Astragalus, Poria, Hawthorn, Buddha's Hand, Raspberry, Polygonatum, Dry Ginger, Turmeric, Tangerine Peel, Polygonatum, Pueraria lobata, Peach Kernel, Cinnamon Bark, Mulberry Leaf, and Chrysanthemum are selected as raw materials, and then the raw materials are screened to remove impurities and moldy parts, and then washed with running water for 3 to 5 times. After washing, they are dried at 55-65° C. to a moisture content of ≤8%, and finally crushed to 80-120 mesh.

[0011] Preferably, step S2 specifically includes: The raw material treated in step S1 is placed in a multifunctional extraction tank, deionized water is added, and the mixture is soaked for 30 to 60 minutes. The mixture is first extracted over high heat for 0.5 to 1.5 hours, and then extracted over low heat for 20 to 40 minutes. After the extraction, a plate and frame filter press is used for solid-liquid separation, and the filtrate is collected. Deionized water is then added to the filter residue, and the above extraction process is repeated, and the two filtrates are combined.

[0012] Preferably, step S3 specifically includes: The filtrate obtained in step S2 is concentrated under reduced pressure at a vacuum degree of 0.06-0.09 MPa and a temperature of 55-65° C. to a clear paste with a relative density of 1.15-1.25 (60° C.).

[0013] Preferably, step S4 specifically includes: The granules are prepared by drying the composite liquid obtained in step S3 through a spray drying tower at an air inlet temperature of 160-180°C, an air outlet temperature of 70-80°C, and an atomization pressure of 1.5-3 MPa to obtain a dry paste powder; the dry paste powder is uniformly mixed with an appropriate amount of starch and dextrin, granulated by a wet method, passed through a 14-20 mesh sieve, and dried at 60-70°C to a moisture content of ≤5%. After granulation, the granules are divided into 5g bags, packed in nitrogen with a nitrogen purity of ≥99.5%, and sealed and metal detected.

[0014] The present invention has the following beneficial effects: 1. This multi-target synergistic conditioning Chinese medicine composition and its preparation method adopt the combination of medicinal materials with the same origin as food. Through the synergistic action of multiple targets, it can effectively regulate multiple diseases such as constipation, ulcerative colitis, hemorrhoids, obesity, sleep disorders, etc., realize the multi-purpose use of one medicine, and meet the comprehensive treatment needs of patients.

[0015] 2. This multi-target synergistic Chinese medicine composition and its preparation method have high safety, avoid the dependence and side effects that may be caused by Western medicine, and are more beneficial to human health. At the same time, compared with traditional complex Chinese medicine formulas, this formula is more targeted and has significant efficacy, and can accurately act on the root cause of the disease. In addition, the preparation method is simple to operate, and the process parameters are easy to control. It is suitable for industrial large-scale production, which is conducive to reducing production costs, ensuring the stability and consistency of product quality, and facilitating the promotion and application of products.

[0016] 3. This multi-target synergistic conditioning Chinese medicine composition and its preparation method use astragalus, kudzu root, mulberry leaf, and chrysanthemum to replenish qi and raise yang, dilate blood vessels, clear the liver and purge fire, improve qi deficiency type hypertension and dizziness and headache caused by hyperactivity of liver yang; use hawthorn, turmeric, poria, and tangerine peel to inhibit lipid synthesis, promote fat decomposition, strengthen the spleen and eliminate dampness, and lower serum cholesterol and triglycerides; use poria, hawthorn, turmeric, and cinnamon to promote uric acid excretion, improve renal microcirculation, anti-inflammatory and analgesic, and assist in regulating gouty arthritis; then use kudzu root, mulberry leaf, polygonatum, and polygonatum to improve insulin sensitivity, delay blood sugar rise, nourish yin and moisten dryness, and improve the symptoms of yin deficiency type diabetes, thereby achieving the effect of regulating hyperglycemia, hypertension, hyperlipidemia, and hyperuricemia. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0018] A multi-target synergistic conditioning Chinese medicine composition comprises: astragalus, poria, hawthorn, bergamot, raspberry, polygonatum, dried ginger, turmeric, tangerine peel, polygonatum, kudzu root, peach kernel, cinnamon bark, mulberry leaf, and chrysanthemum.

[0019] In a preferred embodiment, the invention is composed of the following components in weight percentage: 10% to 15% of astragalus, 5% to 7% of poria, 5% to 7% of hawthorn, 5% to 7% of bergamot, 5% to 7% of raspberry, 5% to 7% of polygonatum, 5% to 7% of dried ginger, 5% to 7% of turmeric, 5% to 7% of tangerine peel, 5% to 7% of polygonatum, 10% to 15% of kudzu root, 5% to 7% of peach kernel, 5% to 7% of cinnamon bark, 5% to 7% of mulberry leaf, and 5% to 7% of chrysanthemum.

[0020] In a preferred embodiment, the invention is composed of the following components in weight percentage: 12% Astragalus, 6% Poria, 6% Hawthorn, 6% Buddha's hand, 6% Raspberry, 6% Polygonatum, 6% Dried ginger, 6% Turmeric, 6% Tangerine peel, 6% Polygonatum, 12% Pueraria, 6% Peach kernel, 6% Cinnamon, 6% Mulberry leaf, and 6% Chrysanthemum.

[0021] Principle of compatibility: Combining the properties, flavors, meridians and effects of each herbal medicine, this formula is scientific: (1) Constipation (especially due to Qi deficiency and dry intestines) Qi-tonifying and promoting movement (Astragalus + Pueraria): Astragalus nourishes the spleen and lung qi, enhancing intestinal motility and improving qi-deficiency constipation characterized by "the urge to defecate but with difficulty, sweating, and shortness of breath." Pueraria promotes fluid production and moisturizes dryness, alleviating intestinal dryness and synergizing with Astragalus to increase fluid flow. Intestinal moistening and laxative (peach kernel + polygonatum + raspberry): Peach kernel promotes blood circulation and moistens the intestines, promoting intestinal fluid secretion; polygonatum nourishes yin and produces body fluid, softening dry stool; raspberry nourishes the kidneys and strengthens essence, regulating the opening and closing of the intestines (especially suitable for elderly people with kidney deficiency and constipation); (2) Ulcerative colitis (both active and remission phases) Toxin-removing and tissue-regenerating (Astragalus + Turmeric): Astragalus promotes mucosal repair and relieves ulcer pain, making it a "holy medicine for sores." Curcumin inhibits the colonic NF-κB pathway, alleviating intestinal mucosal inflammation and oxidative damage. Clearing heat and drying dampness (mulberry leaves + chrysanthemum + poria): mulberry leaves and chrysanthemums clear dampness and heat from the liver and intestines, inhibiting intestinal pathogens (such as E. coli); poria strengthens the spleen and eliminates dampness, reduces mucus in stool, and repairs the intestinal barrier. Warming the middle and protecting the mucosa (dried ginger + cinnamon + polygonatum): dried ginger warms the middle and stops bleeding, cinnamon improves intestinal circulation and reduces ulcer bleeding; polygonatum replenishes both qi and yin and repairs mucosal atrophy; (3) Hemorrhoids (Qi and blood stasis with damp-heat) Lifting and Strengthening (Astragalus + Pueraria): Astragalus replenishes Qi and raises Yang, improving rectal prolapse; Pueraria produces fluid and astringes, alleviating hemorrhoidal edema. Promote blood circulation and reduce swelling (peach kernel + turmeric + hawthorn): peach kernel dissolves blood stasis and dredges meridians, turmeric resists thrombosis and improves perianal circulation; hawthorn dissolves blood stasis and relieves hemorrhoidal congestion; Heat-clearing and hemostasis (mulberry leaf + chrysanthemum): Both cool the blood and stop bleeding, reduce hemorrhoidal bleeding, and resist anal infection; (4) Obesity conditioning (promoting diuresis and eliminating dampness, promoting metabolism, warming yang and transforming fat) Promote metabolism (Hawthorn + Turmeric) Hawthorn: Lowers blood lipids, accelerates fat decomposition, and eliminates food stagnation; Turmeric: Regulates lipid metabolism gene expression and reduces fat synthesis; Diuresis and Dampness Elimination (Poria cocos + Tangerine peel): Poria cocos strengthens the spleen and promotes diuresis, eliminating phlegm-dampness-induced obesity and edema; Tangerine peel regulates Qi and eliminates dampness, reducing abdominal distension; Regulate the liver and spleen (Buddha's hand + mulberry leaf): Buddha's hand soothes the liver and relieves depression, improving stress-induced eating; mulberry leaf regulates glycogen conversion and reduces fat accumulation; Warming Yang and Resolving Fat (Cinnamon + Dried Ginger): Cinnamon increases basal metabolic rate, while dried ginger warms and resolves phlegm and dampness in the middle burner, targeting obesity caused by deficiency and cold. (5) Sleep disorders (spleen and stomach disharmony, mind and spirit disharmony) Strengthen the spleen and calm the mind (Poria cocos + Polygonatum sibiricum + Polygonatum odoratum): Poria cocos calms the mind and eliminates dampness, improving insomnia caused by spleen deficiency; Polygonatum sibiricum and Polygonatum odoratum nourish yin and moisten dryness, alleviating restlessness and insomnia caused by yin deficiency, dryness and heat; Soothing the Liver and Regulating Qi (Buddha's Hand + Tangerine Peel): Buddha's Hand relieves depression and calms the mind, while Tangerine Peel regulates Qi and harmonizes the stomach. Together, they help regulate restlessness caused by "liver-stomach disharmony"; Leading Yang into Yin (Cinnamon + Dried Ginger): Cinnamon leads fire back to its origin, dried ginger warms the middle and dispels cold, coordinating yin and yang to improve insomnia of the "upper heat and lower cold" type.

[0022] In a preferred embodiment, the weight ratio of Astragalus membranaceus to Pueraria lobata is 1:1.

[0023] Astragalus and Pueraria root are the main medicines, which can replenish qi, raise yang, promote fluid production and relieve dryness; Poria, hawthorn, tangerine peel, etc. are used as auxiliary medicines to strengthen the spleen and stomach, regulate qi and eliminate dampness; peach kernel, turmeric, and cinnamon are used as adjuvant medicines to promote blood circulation and warm the meridians; mulberry leaves and chrysanthemum are used as guiding medicines to clear heat and calm the liver. The whole formula takes into account replenishing qi and activating blood circulation, strengthening the spleen and removing dampness, clearing heat and moistening the intestines, promoting metabolism and fat reduction, which is in line with the pathogenesis of intestinal diseases of qi deficiency, damp-heat and blood stasis type and secondary sleep disorders.

[0024] In a preferred embodiment, the method comprises the following steps: Step S1: raw material pretreatment; Step S2: active ingredient extraction; Step S3: concentration and compounding; Step S4: Molding and packaging.

[0025] In a preferred embodiment, step S1 specifically includes: Astragalus, Poria, Hawthorn, Buddha's Hand, Raspberry, Polygonatum, Dry Ginger, Turmeric, Tangerine Peel, Polygonatum, Pueraria lobata, Peach Kernel, Cinnamon Bark, Mulberry Leaf, and Chrysanthemum are selected as raw materials, and then the raw materials are screened to remove impurities and moldy parts, and then washed with running water for 3 to 5 times. After washing, they are dried at 55-65° C. to a moisture content of ≤8%, and finally crushed to 80-120 mesh.

[0026] In a preferred embodiment, step S2 specifically includes: The raw material treated in step S1 is placed in a multifunctional extraction tank, deionized water is added, and the mixture is soaked for 30 to 60 minutes. The mixture is first extracted over high heat for 0.5 to 1.5 hours, and then extracted over low heat for 20 to 40 minutes. After the extraction, a plate and frame filter press is used for solid-liquid separation, and the filtrate is collected. Deionized water is then added to the filter residue, and the above extraction process is repeated, and the two filtrates are combined.

[0027] In a preferred embodiment, step S3 specifically includes: The filtrate obtained in step S2 is concentrated under reduced pressure at a vacuum degree of 0.06-0.09 MPa and a temperature of 55-65° C. to a clear paste with a relative density of 1.15-1.25 (60° C.).

[0028] In a preferred embodiment, step S4 specifically includes: The granules are prepared by drying the composite liquid obtained in step S3 through a spray drying tower at an air inlet temperature of 160-180°C, an air outlet temperature of 70-80°C, and an atomization pressure of 1.5-3 MPa to obtain a dry paste powder; the dry paste powder is uniformly mixed with an appropriate amount of starch and dextrin, granulated by a wet method, passed through a 14-20 mesh sieve, and dried at 60-70°C to a moisture content of ≤5%. After granulation, the granules are divided into 5g bags, packed in nitrogen with a nitrogen purity of ≥99.5%, and sealed and metal detected.

[0029] According to the requirements of different dosage forms, appropriate amounts of starch and dextrin are added to the concentrated liquid medicine, and it is made into different dosage forms such as tablets, capsules, granules, etc. through granulation, tableting or filling processes.

[0030] Example 1: According to the above formula ratio, 120g of astragalus, 60g of poria, 60g of hawthorn, 60g of bergamot, 60g of raspberry, 60g of polygonatum, 60g of dried ginger, 60g of turmeric, 60g of tangerine peel, 60g of polygonatum, 120g of kudzu root, 60g of peach kernel, 60g of cinnamon, 60g of mulberry leaf, and 60g of chrysanthemum were weighed. First, the medicinal materials were washed and dried, and then crushed to a suitable particle size; the crushed medicinal materials were decocted with water, decocted over high heat for 1 hour and decocted over low heat for 30 minutes; after filtering the medicinal residue, the filtrate was concentrated; an appropriate amount of starch and dextrin were added to the concentrated medicinal liquid as excipients, and the granules were pressed into tablets, each weighing 0.5g.

[0031] Example 2: The amount of Astragalus membranaceus was adjusted to 10% (i.e., 100 g), the amount of Pueraria root was adjusted to 10% (i.e., 100 g), and the proportions of other ingredients were slightly adjusted accordingly. The same preparation steps as in Example 1 were followed to complete the medicinal material pretreatment, extraction, concentration, and molding operations to prepare tablets. The stability of the therapeutic efficacy of the formulation after the adjusted dosage was verified through clinical observation of patients. 1. Formula Comparison Original formula: Astragalus 12%, Pueraria lobata 12%, and the remaining medicinal materials are in standard proportions (Poria 6%, Hawthorn 6%).

[0032] Adjusted formula: Astragalus 10%, Pueraria lobata 10%, and the proportions of other medicinal materials are slightly adjusted in the same proportion (Poria 5%, Hawthorn 5%).

[0033] 2. Clinical Design Subjects: 100 patients each with constipation, ulcerative colitis, obesity, and sleep disorders, divided into the original formula group (50 patients) and the adjusted formula group (50 patients); Period: 8 weeks, with efficacy recorded every 2 weeks; Indicator: Symptom improvement rate of each disease; 3. Observation Results

[0034] 4. Stability Mechanism The core compatibility remains unchanged: Astragalus root and Pueraria root are still the monarch drugs, the monarch-minister-assistant-guide structure is retained, and the multi-target synergistic effect is stable; Scientific dosage fine-tuning: Astragalus / Kuanga dosage is reduced by only 2%, which is within the conventional effective dosage range of medicinal materials; Process consistency: The process parameters such as decoction and concentration are the same as the original formula to ensure stable extraction of active ingredients.

[0035] V. Conclusion Through clinical observation of patients, the stability of the therapeutic effect of the dose-adjusted formula was verified.

[0036] Example 3: Tablets and capsules were prepared according to the formula ratio of Example 1. The preparation process of tablets was the same as that of Example 1. For capsules, the concentrated drug solution was added with excipients to form granules, and the granules were then filled into capsule shells. The filling amount of each capsule was 0.5 g.

[0037] Example 4: Experimental verification: Acute toxicity test: mice were given the drug by gavage to observe whether there were any toxic side effects; Pharmacodynamic experiments: Constipation model: The bowel-moistening and laxative effect is verified by the defecation time and stool particle count of mice; Ulcerative colitis model: observe the repair of intestinal mucosa; Sleep disorder model: record the sleep time and depth of mice; Clinical observation: patients with target diseases were included and the symptom improvement rates before and after treatment (such as constipation relief rate and sleep score improvement) were compared.

[0038] 1. Acute toxicity test Methods: Mice were orally administered with different doses of the composition, and their behavior and organ pathology were observed for 7 days.

[0039] Results: There was no abnormal reaction in the high-dose group, and the median lethal dose was not detected, indicating high safety.

[0040] 2. Pharmacodynamics Experiment Constipation model Methods: Diphenoxylate was administered orally to mice with constipation, and the time of black stool excretion and the number of stool particles were recorded.

[0041] Results: The time of black stool was shortened by 35% and the number of stool particles increased by 40% in the medium-dose group, which was equivalent to that of Ma Ren Run Chang Wan.

[0042] Ulcerative colitis model Methods: TNBS was used to induce rat model and colon mucosal pathology and inflammatory indicators were observed.

[0043] Results: The mucosal repair score of the combination group decreased by 50%, and the level of inflammatory factors was significantly reduced.

[0044] Sleep disorder model Methods: Sodium pentobarbital was used to induce sleep in mice, and the sleep latency and sleep duration were monitored.

[0045] Results: The combination group's time to fall asleep was shortened by 25% and sleep duration was prolonged by 30%.

[0046] 3. Clinical Observation Subjects: 100 patients each with constipation, ulcerative colitis, and sleep disorders, to compare the efficacy of the combination with western medicine.

[0047] result: The constipation improvement rate is 80%, and the frequency and characteristics of bowel movements are improved; The effectiveness rate of ulcerative colitis mucosal repair is 75%, and diarrhea and bloody stools are alleviated; The PSQI score for sleep disorders decreased by 60%, and there was no dependence on Western medicine.

[0048] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or apparatus.

[0049] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A multi-target synergistic Chinese medicine composition, characterized in that: The traditional Chinese medicine composition comprises: astragalus, tuckahoe, hawthorn, bergamot, raspberry, polygonatum, dried ginger, turmeric, tangerine peel, polygonatum, kudzu root, peach kernel, cinnamon bark, mulberry leaf and chrysanthemum.

2. A multi-target synergistic conditioning Chinese medicine composition according to claim 1, characterized in that: The invention is composed of the following components in weight percentage: 10% to 15% of astragalus, 5% to 7% of poria, 5% to 7% of hawthorn, 5% to 7% of bergamot, 5% to 7% of raspberry, 5% to 7% of polygonatum, 5% to 7% of dried ginger, 5% to 7% of turmeric, 5% to 7% of tangerine peel, 5% to 7% of polygonatum, 10% to 15% of kudzu root, 5% to 7% of peach kernel, 5% to 7% of cinnamon bark, 5% to 7% of mulberry leaf and 5% to 7% of chrysanthemum.

3. A multi-target synergistic conditioning Chinese medicine composition according to claim 2, characterized in that: The invention is composed of the following components in weight percentage: 12% astragalus, 6% poria, 6% hawthorn, 6% bergamot, 6% raspberry, 6% polygonatum, 6% dried ginger, 6% turmeric, 6% tangerine peel, 6% polygonatum, 12% kudzu root, 6% peach kernel, 6% cinnamon bark, 6% mulberry leaf, and 6% chrysanthemum.

4. A multi-target synergistic conditioning Chinese medicine composition according to claim 3, characterized in that: The weight ratio of the astragalus root to the kudzu root is 1:

1.

5. The method for preparing a multi-target synergistic conditioning Chinese medicine composition according to claim 4, characterized in that: The following steps are involved: Step S1: raw material pretreatment; Step S2: active ingredient extraction; Step S3: concentration and compounding; Step S4: molding and packaging.

6. The method for preparing a multi-target synergistic conditioning Chinese medicine composition according to claim 5, characterized in that: Step S1 specifically includes: 12% of Astragalus, 6% of Poria, 6% of Hawthorn, 6% of Citron, 6% of Raspberry, 6% of Polygonatum, 6% of Dry Ginger, 6% of Turmeric, 6% of Tangerine Peel, 6% of Polygonatum, 12% of Pueraria, 6% of Peach Kernel, 6% of Cinnamon Bark, 6% of Mulberry Leaf, and 6% of Chrysanthemum were selected as raw materials, and then the raw materials were screened to remove impurities and moldy parts, and then washed with running water for 3 to 5 times. After washing, they were dried at 55-65°C to a moisture content of ≤8%, and finally crushed to 80-120 mesh.

7. The method for preparing a multi-target synergistic conditioning Chinese medicine composition according to claim 6, characterized in that: Step S2 specifically includes: The raw material treated in step S1 is placed in a multifunctional extraction tank, deionized water is added, and the mixture is soaked for 30 to 60 minutes. The mixture is first extracted over high heat for 0.5 to 1.5 hours, and then extracted over low heat for 20 to 40 minutes. After the extraction, a plate and frame filter press is used for solid-liquid separation, and the filtrate is collected. Deionized water is then added to the filter residue, and the above extraction process is repeated, and the two filtrates are combined.

8. The method for preparing a multi-target synergistic conditioning Chinese medicine composition according to claim 7, characterized in that: Step S3 specifically includes: The filtrate obtained in step S2 is concentrated under reduced pressure at a vacuum degree of 0.06-0.09 MPa and a temperature of 55-65° C. to a clear paste with a relative density of 1.15-1.25 (60° C.).

9. The method for preparing a multi-target synergistic conditioning Chinese medicine composition according to claim 8, characterized in that: Step S4 specifically includes: The granules are prepared by drying the composite liquid obtained in step S3 through a spray drying tower at an air inlet temperature of 160-180°C, an air outlet temperature of 70-80°C, and an atomization pressure of 1.5-3 MPa to obtain a dry paste powder; the dry paste powder is uniformly mixed with an appropriate amount of starch and dextrin, granulated by a wet method, passed through a 14-20 mesh sieve, and dried at 60-70°C to a moisture content of ≤5%. After granulation, the granules are divided into 5g bags, packed in nitrogen with a nitrogen purity of ≥99.5%, and sealed and metal detected.

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