Preparation method of Chinese olive dropping pill

Abstract

The invention discloses a preparation method of Chinese olive dropping pills, and belongs to the technical field of pharmaceutical preparations. The method comprises the following steps: dissolving a Chinese olive extract in absolute ethyl alcohol, mixing and melting with polyethylene glycol matrixes (PEG6000 and PEG4000) according to different proportions, and dripping and forming in a condensing medium, so as to obtain the Chinese olive dripping pills with uniform appearance, qualified quality and good dissolution performance. The method is stable in process and simple and convenient to operate, can effectively improve the availability of medicinal components of the Chinese olive and the medication compliance of a patient, and is suitable for development of modern Chinese herbal preparations of the Chinese olive.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of Qingguo dripping pills, a modernized preparation form of the traditional Chinese medicine Qingguo. Background Art

[0002] Qingguo (green fruit) is the dried, mature fruit of the olive plant Canarium album Raeusch. (Olive family). It has the benefits of clearing heat and detoxifying, relieving sore throat and promoting salivation. Traditional methods of administration, such as decoctions or powders, suffer from inconvenience, inaccurate dosage, and poor taste. As a new solid dispersion oral preparation, the drop pill formulation offers advantages such as portability, rapid absorption, and stable formation, potentially enhancing the modern application value of Traditional Chinese Medicine. Currently, there is no publicly available technology for the formulation of drop pills specifically for Qingguo extract, leaving room for innovation and practical application. Summary of the Invention

[0003] The purpose of the present invention is to provide a preparation method of Qingguo dropping pills, which improves the pill forming property, quality consistency and drug release performance by optimizing the ratio of PEG6000 to PEG4000.

[0004] The present invention adopts the following technical solutions: A method for preparing Qingguo dripping pills comprises the following steps: Raw material preparation: weigh 0.35 g of green fruit extract; Dissolution and matrix melting: The green fruit extract was dissolved in anhydrous ethanol in a 60 °C water bath; Add matrix materials: PEG6000 and PEG4000 in a ratio of 3:7, with a total mass of 10 g; Mixing and melting: melt PEG in a water bath at 80℃, add green fruit extract and stir evenly to form a liquid; Drop-molding: The liquid medicine is made into drop pills by a drop pill machine, and then dropped into a condensing medium to cool and form; Drying and collection: The pellets are dried, the surface grease is removed and then collected for later use. Beneficial effects

[0005] The present invention has the following advantages: 1. Improve the efficacy of Qingguo and patient compliance; 2. The release rate can be adjusted to meet different clinical needs; 3. The process is simple, controllable, and suitable for industrial promotion; 4. Good molding, excellent solubility and accurate dosage. DETAILED DESCRIPTION

[0006] Example 1: Dissolve 0.35 g of green fruit extract in 1-2 mL of anhydrous ethanol. Weigh 10.00 g of PEG6000 and melt in an 80°C water bath. Add the green fruit extract and stir for 30 minutes until a homogenous solution is obtained. Then, pellets are formed using a pellet machine. The pellets are cooled, formed, and then dried to obtain the finished product. The pellets have a good appearance, a dissolution time of less than 6 minutes, and excellent content consistency. Example

[0007] Dissolve 0.35 g of green fruit extract in 1–2 mL of anhydrous ethanol. Weigh 5.00 g of PEG6000 and 5.00 g of PEG4000 and melt in an 80°C water bath. Add the green fruit extract and stir for 30 minutes until a homogeneous solution is obtained. Then, form the pellets using a pellet machine. Cool the pellets, form them, and dry them to obtain the finished product. The pellets have a good appearance, a dissolution time of less than 6 minutes, and excellent content consistency. Example

[0008] Dissolve 0.35 g of green fruit extract in 1–2 mL of anhydrous ethanol. Weigh 10.00 g of PEG4000 and melt in an 80°C water bath. Add the green fruit extract and stir for 30 minutes until a homogeneous solution is obtained. Then, pellets are formed using a pellet machine. The pellets are cooled, formed, and then dried to obtain the finished product. The pellets have a good appearance, a dissolution time of less than 6 minutes, and excellent content consistency. Example

[0009] Dissolve 0.35 g of green fruit extract in 1–2 mL of anhydrous ethanol. Weigh 3.00 g of PEG6000 and 7.00 g of PEG4000 and melt in an 80°C water bath. Add the green fruit extract and stir for 30 minutes until a homogeneous solution is obtained. Then, pellets are formed using a pellet machine. The pellets are cooled, formed, and then dried to obtain the finished product. The pellets have a good appearance, a dissolution time of less than 6 minutes, and excellent content consistency.

Claims

1. A method for preparing Qingguo dripping pills, characterized by comprising the following steps: (1) The green fruit extract was dissolved in anhydrous ethanol; (2) PEG6000 and PEG4000 are mixed with the extract in different proportions and heated to form a medicinal solution; (3) the liquid medicine is dripped into the condensation medium to form pellets; (4) Drying and collecting the pellets.

2. The method for preparing the Qingguo dripping pills according to claim 1, wherein: The invention is prepared from the following materials in parts by weight: 1 part of green fruit extract and 20-40 parts of a mixture of PEG6000 and PEG4000.

3. The method for preparing the Qingguo dripping pills according to claim 1, wherein: The ratio of PEG6000 to PEG4000 is in the range of 0:10-10:

0.

4. The method for preparing Qingguo dripping pills according to claim 1, characterized in that: The mixture of PEG6000 and PEG4000 needs to be melted in a water bath at 60-90°C.

5. The dropping pills according to any one of claims 1 to 4, which are spherical in appearance, uniform in size and uniform in color, all of which are brownish yellow.