Traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating haemorrhoids and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of radix arnebiae seu lithospermi, 18-22 parts of rhizoma coptidis, 18-22 parts of cortex phellodendri, 30-40 parts of herba taraxaci, 10-14 parts of borneol, 12-18 parts of radix sanguisorbae, 12-18 parts of flos sophorae, 8-12 parts of gallnut, 12-18 parts of radix sophorae flavescentis, 8-12 parts of radix angelicae sinensis, 10-14 parts of radix paeoniae rubra, 8-12 parts of radix angelicae dahuricae, 8-12 parts of radix et rhizoma rhei, 6-10 parts of frankincense and 6-10 parts of myrrh. The traditional Chinese medicine suppository composition has multiple effects of cooling blood and stopping bleeding, clearing heat and drying dampness, promoting blood circulation to remove blood stasis, relieving swelling and pain and the like through scientific compatibility of fifteen traditional Chinese medicines such as lithospermum, goldthread root and the like, improves symptoms such as hemorrhoid bleeding, swelling and pain, itching and the like through multi-target synergism, promotes wound healing, regulates intestinal functions and prevents relapse, and has a good application prospect. Compared with a traditional single-component medicine, the traditional Chinese medicine composition has more comprehensive, safe and efficient treatment advantages.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating hemorrhoids and a preparation method thereof. Background Art

[0002] Hemorrhoids are a common anorectal disease characterized by symptoms such as anal pain, bloody stools, and itching, severely impacting patients' quality of life. A wide variety of medications are currently available for the treatment of hemorrhoids, but most suffer from limited efficacy and high recurrence rates. Traditional Chinese medicine suppositories offer advantages in treating hemorrhoids, but they still suffer from limitations such as poor drug penetration and a short duration of action.

[0003] Some existing hemorrhoid treatment drugs contain chemical ingredients, such as local anesthetics and steroids, which may cause irritation or allergic reactions in some people. At the same time, they only focus on relieving symptoms and lack multi-effect therapeutic effects. Summary of the Invention

[0004] The purpose of the present invention is to solve the shortcomings of the prior art and to provide a Chinese medicine composition for treating hemorrhoids and a preparation method thereof.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A traditional Chinese medicine composition for treating hemorrhoids comprises the following raw materials in parts by weight: 20-30 parts of lithospermum erythrorhizon, 18-22 parts of coptis chinensis, 18-22 parts of phellodendron amurense, 30-40 parts of dandelion, 10-14 parts of borneol, 12-18 parts of sanguisorba officinalis, 12-18 parts of sophora japonica flowers, 8-12 parts of gallnut, 12-18 parts of sophora flavescens, 8-12 parts of angelica sinensis, 10-14 parts of red peony root, 8-12 parts of angelica dahurica, 8-12 parts of rhubarb, 6-10 parts of frankincense, and 6-10 parts of myrrh.

[0007] Preferably, the raw materials are included in parts by weight: 22-28 parts of lithospermum erythrorhizon, 19-21 parts of coptis chinensis, 19-21 parts of phellodendron amurense, 32-38 parts of dandelion, 11-13 parts of borneol, 13-17 parts of sanguisorba officinalis, 13-17 parts of sophora japonica, 9-11 parts of gallnut, 13-17 parts of sophora flavescens, 9-11 parts of angelica sinensis, 11-13 parts of red peony root, 9-11 parts of angelica dahurica, 9-11 parts of rhubarb, 7-9 parts of frankincense, and 7-9 parts of myrrh.

[0008] Preferably, the following raw materials are included in parts by weight: 25 parts of lithospermum erythrorhizon, 20 parts of coptis chinensis, 20 parts of phellodendron amurense, 35 parts of dandelion, 12 parts of borneol, 15 parts of sanguisorba officinalis, 15 parts of sophora japonica, 10 parts of gallnut, 15 parts of sophora flavescens, 10 parts of angelica sinensis, 12 parts of red peony root, 10 parts of angelica dahurica, 10 parts of rhubarb, 8 parts of frankincense, and 8 parts of myrrh.

[0009] Preferably, the following raw materials are included in parts by weight: the weight ratio of Lithospermum erythrorhizon, Coptis chinensis and Phellodendron amurense is 20-30:18-22:18-22.

[0010] Preferably, the raw materials are included in the following parts by weight: the weight ratio of dandelion, borneol and sanguisorba officinalis is 30-40:10-14:12-18.

[0011] Preferably, the raw materials include the following parts by weight: the weight ratios of Sophora japonica flower, Gallnut, Sophora flavescens, Angelica sinensis, Red Peony Root, Angelica dahurica, Rhubarb, Frankincense and Myrrh are 12-18:8-12:12-18, 8-12:10-14:8-12, 8-12:6-10:6-10 respectively.

[0012] A method for preparing a traditional Chinese medicine composition for treating hemorrhoids comprises the following steps:

[0013] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0014] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0015] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0016] S4, cooling the solution A to below 50°C, adding 5 g of borneol per 100 ml of solution A, stirring until completely dissolved, and letting it stand for 8 hours;

[0017] S5, take the supernatant, add 10% fresh aloe vera juice, and stir evenly;

[0018] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0019] Preferably, in S3, the mixed powder B is added with 12 times the amount of boiling water, and simmered for 1.5 hours, during which the mixture is stirred every 20 minutes. After the mixture is decocted, the medicinal solution A is obtained by filtering.

[0020] In the present invention, Lithospermum officinale is used for cooling blood, activating blood circulation, detoxifying and reducing swelling, which helps to improve local blood circulation of hemorrhoids and alleviate inflammatory reactions; Coptis chinensis has the effects of clearing heat and drying dampness, purging fire and detoxifying, and has a significant improvement effect on the damp-heat symptoms caused by hemorrhoids; Phellodendron chinense clears heat and dries dampness, purges fire and eliminates steam, and synergizes with Coptis chinensis to enhance the heat-clearing effect; Taraxacum officinale clears heat and detoxifies, reduces swelling and disperses stagnation, and helps to dissipate local lumps of hemorrhoids; Borneol clears heat and relieves pain, promotes drug penetration, and can enhance the effects of other drugs; Sanguisorba officinalis cools blood and stops bleeding, astringes and reduces swelling, and has a good effect on the symptoms of hemorrhoidal bleeding; Sophora japonica clears heat and cools blood, improves blood in stool, and is particularly effective for the symptoms of hemorrhoidal blood in stool. The invention discloses a kind of Chinese medicine suppository composition of the present invention, comprising the following components: astringent hemostasis, swelling and pain relief, sophora flavescens, and parasite-killing antipruritic, which can relieve the pruritus caused by hemorrhoids; Radix Angelicae Sinensis, which can invigorate blood circulation and dissipate blood stasis, promote local blood circulation, and help improve the local blood stasis state of hemorrhoids; Radix Paeoniae Rubra, which can invigorate blood circulation and dissipate blood stasis, relieve pain, and has a relieving effect on hemorrhoidal pain; Radix Angelicae Dahuricae, which can reduce swelling and discharge pus, relieve pain and promote granulation, and help hemorrhoidal wound healing; Radix Rhei, which can purge fire and relieve constipation, can prevent hemorrhoidal symptoms from increasing the weight of due to constipation; frankincense, which can invigorate blood circulation and stop pain, promote wound healing, and accelerate hemorrhoid recovery; Myrrha, which can dissipate blood stasis and stop pain, enhance anti-inflammatory effect, and alleviate hemorrhoidal inflammatory reaction. In addition, the Chinese medicine suppository composition of the present invention pays more attention to the therapeutic effect of comprehensive conditioning and multi-effect integration, and through the synergistic effect of multiple drugs, is intended to treat and nurse hemorrhoids from many aspects, and is more safe and reliable than the hemorrhoidal medicines of some single ingredients or mechanisms of action on the market. DETAILED DESCRIPTION

[0021] The present invention will be further explained below with reference to specific embodiments.

[0022] Example 1

[0023] The invention provides a traditional Chinese medicine composition for treating hemorrhoids, comprising the following raw materials in parts by weight: 20 parts of lithospermum erythrorhizon, 18 parts of coptis chinensis, 18 parts of phellodendron amurense, 30 parts of dandelion, 10 parts of borneol, 12 parts of sanguisorba officinalis, 12 parts of sophora japonica flowers, 8 parts of gallnut, 12 parts of sophora flavescens, 8 parts of angelica sinensis, 10 parts of red peony root, 8 parts of angelica dahurica, 8 parts of rhubarb, 6 parts of frankincense and 6 parts of myrrh.

[0024] The preparation method comprises the following steps:

[0025] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0026] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0027] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0028] S4, cooling the solution A to below 50°C, adding 5 g of borneol per 100 ml of solution A, stirring until completely dissolved, and letting it stand for 8 hours;

[0029] S5, take the supernatant, add 10% fresh aloe vera juice (or aloe vera gel extract), and stir evenly;

[0030] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0031] Example 2

[0032] The invention provides a traditional Chinese medicine composition for treating hemorrhoids, comprising the following raw materials in parts by weight: 22 parts of lithospermum erythrorhizon, 19 parts of coptis chinensis, 19 parts of phellodendron amurense, 32 parts of dandelion, 11 parts of borneol, 13 parts of sanguisorba officinalis, 13 parts of sophora japonica flowers, 9 parts of gallnut, 13 parts of sophora flavescens, 9 parts of angelica sinensis, 11 parts of red peony root, 9 parts of angelica dahurica, 9 parts of rhubarb, 7 parts of frankincense and 7 parts of myrrh.

[0033] The preparation method comprises the following steps:

[0034] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0035] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0036] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0037] S4, cool the solution A to below 50°C, add 5 g of borneol per 100 ml of solution A, stir until completely dissolved, and let stand for 8 hours (preferably refrigerated at 4°C);

[0038] S5, take the supernatant, add 10% fresh aloe vera juice (or aloe vera gel extract), and stir evenly;

[0039] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0040] Example 3

[0041] The invention provides a traditional Chinese medicine composition for treating hemorrhoids. The composition comprises the following raw materials in parts by weight: 25 parts of lithospermum erythrorhizon, 20 parts of coptis chinensis, 20 parts of phellodendron amurense, 35 parts of dandelion, 12 parts of borneol, 15 parts of sanguisorba officinalis, 15 parts of sophora japonica flowers, 10 parts of gallnut, 15 parts of sophora flavescens, 10 parts of angelica sinensis, 12 parts of red peony root, 10 parts of angelica dahurica, 10 parts of rhubarb, 8 parts of frankincense and 8 parts of myrrh.

[0042] The preparation method comprises the following steps:

[0043] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0044] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0045] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0046] S4, cool the solution A to below 50°C, add 5 g of borneol per 100 ml of solution A, stir until completely dissolved, and let stand for 8 hours (preferably refrigerated at 4°C);

[0047] S5, take the supernatant, add 10% fresh aloe vera juice (or aloe vera gel extract), and stir evenly;

[0048] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0049] Example 4

[0050] The invention provides a traditional Chinese medicine composition for treating hemorrhoids, comprising the following raw materials in parts by weight: 28 parts of lithospermum erythrorhizon, 21 parts of coptis chinensis, 21 parts of phellodendron amurense, 38 parts of dandelion, 13 parts of borneol, 17 parts of sanguisorba officinalis, 17 parts of sophora japonica flowers, 11 parts of gallnut, 17 parts of sophora flavescens, 11 parts of angelica sinensis, 13 parts of red peony root, 11 parts of angelica dahurica, 11 parts of rhubarb, 9 parts of frankincense and 9 parts of myrrh.

[0051] The preparation method comprises the following steps:

[0052] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0053] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0054] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0055] S4, cool the solution A to below 50°C, add 5 g of borneol per 100 ml of solution A, stir until completely dissolved, and let stand for 8 hours (preferably refrigerated at 4°C);

[0056] S5, take the supernatant, add 10% fresh aloe vera juice (or aloe vera gel extract), and stir evenly;

[0057] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0058] Example 5

[0059] The invention provides a traditional Chinese medicine composition for treating hemorrhoids. The composition comprises the following raw materials in parts by weight: 30 parts of lithospermum erythrorhizon, 22 parts of coptis chinensis, 22 parts of phellodendron amurense, 40 parts of dandelion, 14 parts of borneol, 18 parts of sanguisorba officinalis, 18 parts of sophora japonica flowers, 12 parts of gallnut, 18 parts of sophora flavescens, 12 parts of angelica sinensis, 14 parts of red peony root, 12 parts of angelica dahurica, 12 parts of rhubarb, 10 parts of frankincense and 10 parts of myrrh.

[0060] The preparation method comprises the following steps:

[0061] S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A;

[0062] S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B;

[0063] S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A;

[0064] S4, cool the solution A to below 50°C, add 5 g of borneol per 100 ml of solution A, stir until completely dissolved, and let stand for 8 hours (preferably refrigerated at 4°C);

[0065] S5, take the supernatant, add 10% fresh aloe vera juice (or aloe vera gel extract), and stir evenly;

[0066] S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

[0067] In order to test the antibacterial effect of the present invention, the present invention was compared with a certain brand on the market. The antibacterial effects were divided into significant effect, effective, and ineffective. The comparison results are shown in the following table:

[0068] Group Number of cases Total efficiency Recurrence rate The present invention 200 96.5％ 8％ A certain brand 200 82.3％ 25％

[0069] As can be seen from the above table, the present invention has a strong therapeutic effect, can effectively improve the symptoms of hemorrhoids and reduce the recurrence rate.

[0070] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating hemorrhoids, characterized in that: The invention comprises the following raw materials in parts by weight: 20-30 parts of lithospermum erythrorhizon, 18-22 parts of coptis chinensis, 18-22 parts of phellodendron amurense, 30-40 parts of dandelion, 10-14 parts of borneol, 12-18 parts of sanguisorba officinalis, 12-18 parts of sophora japonica flower, 8-12 parts of gallnut, 12-18 parts of sophora flavescens, 8-12 parts of angelica sinensis, 10-14 parts of red peony root, 8-12 parts of angelica dahurica, 8-12 parts of rhubarb, 6-10 parts of frankincense and 6-10 parts of myrrh.

2. A Chinese medicine composition for treating hemorrhoids according to claim 1, characterized in that, The invention comprises the following raw materials in parts by weight: 22-28 parts of lithospermum erythrorhizon, 19-21 parts of coptis chinensis, 19-21 parts of phellodendron amurense, 32-38 parts of dandelion, 11-13 parts of borneol, 13-17 parts of sanguisorba officinalis, 13-17 parts of sophora japonica flower, 9-11 parts of gallnut, 13-17 parts of sophora flavescens, 9-11 parts of angelica sinensis, 11-13 parts of red peony root, 9-11 parts of angelica dahurica, 9-11 parts of rhubarb, 7-9 parts of frankincense and 7-9 parts of myrrh.

3. A Chinese medicine composition for treating hemorrhoids according to claim 1, characterized in that, The invention comprises the following raw materials in parts by weight: 25 parts of lithospermum erythrorhizon, 20 parts of coptis chinensis, 20 parts of phellodendron amurense, 35 parts of dandelion, 12 parts of borneol, 15 parts of sanguisorba officinalis, 15 parts of sophora japonica flowers, 10 parts of gallnut, 15 parts of sophora flavescens, 10 parts of angelica sinensis, 12 parts of red peony root, 10 parts of angelica dahurica, 10 parts of rhubarb, 8 parts of frankincense and 8 parts of myrrh.

4. A Chinese medicine composition for treating hemorrhoids according to claim 1, characterized in that, The weight ratio of Lithospermum erythrorhizon, Coptidis rhizome and Phellodendron amurense is 20-30:18-22:18-22.

5. A Chinese medicine composition for treating hemorrhoids according to claim 1, characterized in that, The weight ratio of the dandelion, borneol and sanguisorba officinalis is 30-40:10-14:12-18.

6. A Chinese medicine composition for treating hemorrhoids according to claim 1, characterized in that, The weight ratios of the sophora japonica flower, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, rhubarb, frankincense and myrrh are respectively 12-18:8-12:12-18, 8-12:10-14:8-12 and 8-12:6-10:6-10.

7. A method for preparing a Chinese medicine composition for treating hemorrhoids according to any one of claims 1 to 6, the method comprising the steps of: S1, according to the proportion of weighed lithospermum erythrorhizon, coptis chinensis, phellodendron amurense, dandelion, sanguisorba officinalis, sophora japonica, gallnut, sophora flavescens, angelica sinensis, red peony root, angelica dahurica, and rhubarb, respectively, wash and dry the above raw materials, then put them into a grinder in turn and grind them into 80 mesh, and then mix them to obtain mixed powder A; S2, weighing borneol according to the proportion, grinding the borneol into a fine powder, and mixing it with mixed powder A to obtain mixed powder B; S3, add 10 times the amount of mixed powder B into boiling water, simmer for 1 hour, stir every 15 minutes, and filter to obtain liquid A; S4, cooling the solution A to below 50°C, adding 5 g of borneol per 100 ml of solution A, stirring until completely dissolved, and letting it stand for 8 hours; S5, take the supernatant, add 10% fresh aloe vera juice, and stir evenly; S6, filling the medicinal solution A into 15 mL disposable sterile syringes, sealing and sterilizing at 60° C. for 30 minutes, thereby obtaining a traditional Chinese medicine suppository composition for the efficient treatment of hemorrhoids.

8. A method for preparing a Chinese medicine composition for treating hemorrhoids according to claim 7, characterized in that: In S3, the mixed powder B is added with 12 times the amount of boiling water, and simmered for 1.5 hours, stirring once every 20 minutes. After the simmered powder B is simmered, the medicinal solution A is obtained by filtering.